A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
NSC 177223. Group: Biochemicals. Alternative Names: 4-Amino-5,8-dihydro-5-oxo-8- β-D-ribofuranosyl-pyrido[2,3-d]pyrimidine-6-carboxamide; API-1. Grades: Highly Purified. CAS No. 36707-00-3. Pack Sizes: 5mg. Molecular Formula: C13H15N5O6, Molecular Weight: 337.29. US Biological Life Sciences.
Worldwide
NSC 185058
NSC 185058 is an inhibitor of ATG4B, a major cysteine protease. Inhibition of ATG4B using NSC 185058 markedly attenuates autophagic activity[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 39122-38-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-125169.
NSC 194308
NSC 194308, a U2AF2-RNA complexes enhancer, increases association of the U2AF1-U2AF2-SF1-splice site RNA complex by binding a site between the U2AF2 RNA recognition motifs (RRM1 and RRM2). NSC 194308 inhibits pre-mRNA splicing by stalling spliceosome assembly at the point where U2AF helps recruit U2 snRNP to the branchpoint. NSC 194308 enhances the binding of pre-mRNA to U2AF2, selectively triggering cell death in leukemia cell lines containing spliceosome mutations[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 90379-42-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-153736.
NSC 228155
NSC 228155 is an activator of EGFR, binds to the extracellular region of EGFR and enhance tyrosine phosphorylation of EGFR[1]. NSC 228155 is also a potent inhibitor of KIX-KID interaction, inhibits kinase-inducible domain (KID) from CREB and KID-interacting domain (KIX) from CBP, with an IC50 of 0.36 ?M[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 113104-25-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101084.
NSC 23005 Sodium Salt
NSC 23005 Sodium Salt is used to perpare sodium sodium cyclohexyl aminosulfonyl benzoate as p18 micromolecule inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 1796596-46-7. Pack Sizes: 1mg, 5mg. Molecular Formula: C13H16NNaO4S, Molecular Weight: 305.33. US Biological Life Sciences.
Worldwide
NSC232003
NSC232003 is a highly potent and cell-permeable UHRF1 inhibitor, which inhibits DNA methylation in vitro and disrupts DNMT1/UHRF1 interactions at a cellular level. Uses: Scientific research. Group: Signaling pathways. CAS No. 1905453-18-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-103236.
NSC 23766
NSC 23766 is a cell-permeable, reversible and specific inhibitor of Rac GTPase, used for cancer treatment. Uses: Scientific research. Group: Signaling pathways. CAS No. 733767-34-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15723.
NSC 23766 trihydrochloride
NSC 23766 trihydrochloride is an inhibitor of Rac1 activation. Uses: Scientific research. Group: Signaling pathways. CAS No. 1177865-17-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15723A.
NSC23925 is a novel, selective and effective P-glycoprotein ( Pgp ) inhibitor. Uses: Scientific research. Group: Signaling pathways. CAS No. 858474-14-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-19626.
NSC 245214
NSC 245214 is a thienyl cycloalkanone that is part of the US National Cancer Institute small molecule repository. The biological activity of this compound has not been reported. Group: Biochemicals. Alternative Names: 2-(3,5-dinitro-2-thienyl)-cyclohexanone. Grades: Highly Purified. CAS No. 31554-45-7. Pack Sizes: 1mg, 5mg, 10mg, 25mg. Molecular Formula: C10H10N2O5S, Form: Supplied as a crystalline. US Biological Life Sciences.
NSC 280449 is a derivative of Tromethamine (T892600); a compound that is widely used in biochemistry and molecular biology. In medicine, Tromethamine is used as an alternative to sodium bicarbonate in the treatment of metabolic acidosis. Group: Biochemicals. Grades: Highly Purified. CAS No. 60204-53-7. Pack Sizes: 100mg, 500mg. Molecular Formula: C10H17NO3, Molecular Weight: 199.25. US Biological Life Sciences.
Worldwide
NSC2805
NSC2805 is a WWP2 ubiquitin ligase inhibitor that can significant inhibit WWP2 activity with an IC50 of 0.38 ?M. NSC2805 can be used for the research of cancer[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 4371-34-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134417.
NSC 295642
NSC 295642. Uses: Designed for use in research and industrial production. Additional or Alternative Names: NSC 295642, [1-(2-pyridinyl)ethylidene]-Hydrazinecarbodithioic acid, phenylmethyl ester, copper complex, 77111-29-6, Bis-[chloro[phenylmethyl [1-(2-pyridinyl)ethylidene]hydrazinecarbodithioato-N2,N2 inverted exclamation marka,S1 inverted exclamation mark ]-copper], Cu(II) complex of the Schiff base product of condensation of S-benzyl dithiocarbazate and 2-acetylpyridine. Product Category: Heterocyclic Organic Compound. CAS No. 77111-29-6. Molecular formula: C15H14ClCuN3S2. Mole weight: 798.84. Purity: 0.96. IUPACName: (E)-benzylsulfanyl-[(E)-1-pyridin-2-ylethylidenehydrazinylidene]-sulfidomethane;chlorocopper(1+). Canonical SMILES: CC(=NN=C([S-])SCC1=CC=CC=C1)C2=CC=CC=N2.Cl[Cu+]. Product ID: ACM77111296. Alfa Chemistry ISO 9001:2015 Certified. Categories: DTXSID20444568.
NSC-33994 is novel inhibitor of JAK2 tyrosine kinase (Janus kinase 2 ). Janus kinase 2 (JAK2) plays a crucial role in the pathomechanism of myeloproliferative disorders and hematological malignancies. Group: Biochemicals. Alternative Names: 4, 4'-[ (1E) -1, 2-Diethyl-1, 2-ethenediyl]bis[2-[ (diethylamino) methyl]phenol; (E) -4, 4'- (1, 2-Diethyl-1, 2-ethenediyl) bis[2-[ (diethylamino) methyl]phenol. Grades: Highly Purified. CAS No. 82058-16-0. Pack Sizes: 50mg. US Biological Life Sciences.
NSC 405020. Group: Biochemicals. Grades: Purified. CAS No. 7497-7-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
NSC 405020
NSC 405020 is a specific MMP14 inhibitor. NSC 405020 can directly interact with the hemopexin domain of MMP14. NSC 405020 reduces the expression of full length and active cleaved Notch3 (NICD3). NSC 405020 can be used to research vestibular schwannoma, hemostasis and thrombosis[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 7497-7-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15827.
Nsc42165
Nsc42165. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Nsc42165. Product Category: Heterocyclic Organic Compound. CAS No. 17596-06-4. Mole weight: 0. Product ID: ACM17596064. Alfa Chemistry ISO 9001:2015 Certified. Categories: 4,4'-(Diazoamino)dibenzenesulfonic acid.
NSC 42834
NSC 42834 (JAK2 Inhibitor V), a novel specific inhibitor of Jak2, inhibits Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner but was not cytotoxic to cells at concentrations that inhibited kinase activity. Uses: Scientific research. Group: Signaling pathways. Alternative Names: JAK2 Inhibitor V; Z3. CAS No. 195371-52-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15480.
NSC 617145 is a selective werner syndrome helicase (WRN) helicase inhibitor with an IC50 value of 230 nM. NSC 617145 inhibits WRN ATPase, and induces double-strand breaks (DSB) and chromosomal abnormalities. NSC 617145 shows selective for WRN over BLM, FANCJ, ChlR1, RecQ, and UvrD helicases[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 203115-63-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-110185.
NSC 617145
NSC 617145. Group: Biochemicals. Grades: Purified. CAS No. 203115-63-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
NSC 624206
NSC 624206. Group: Biochemicals. Grades: Purified. CAS No. 13116-77-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
Nsc 625987
NSC 625987 is a specific and high-affinity CDK4 inhibitor with an IC50 of 0.2 μM for CDK4:cyclin D1. NSC 625987 shows >500-fold selectivity for CDK4 over CDK2. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. CAS No. 141992-47-4. Molecular formula: C15H13NO2S. Mole weight: 271.339. Purity: >98 %. Product ID: ACM141992474. Alfa Chemistry ISO 9001:2015 Certified.
NSC 625987
NSC 625987. Group: Biochemicals. Grades: Purified. CAS No. 141992-47-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
NSC632839
NSC632839 is a nonselective isopeptidase inhibitor, which inhibits USP2, USP7, and SENP2 with EC50s of 45±4 ?M, 37±1 ?M, and 9.8±1.8 ?M, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 157654-67-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100708.
NSC 632839 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 157654-67-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
NSC 652287
NSC 652287. Group: Biochemicals. Alternative Names: 5,5'-(2,5-Furandiyl)bis-2-thiophenemethanol; RITA. Grades: Highly Purified. CAS No. 213261-59-7. Pack Sizes: 5mg. Molecular Formula: C14H12O3S2, Molecular Weight: 292.37. US Biological Life Sciences.
Worldwide
Nsc 663284
NSC 663284 (DA-3003-1) is a potent, cell-permeable, and irreversible Cdc25 dual specificity phosphatase inhibitor, has an IC50 for Cdc25B2 of 0.21 μM. NSC 663284 exhibits mixed competitive kinetics against Cdc25A, Cdc25B(2), and Cdc25C with Ki values of 29, 95, and 89 nM, respectively. NSC 663284 inhibits NSD2 (IC50 of 170 nM) through a direct interaction with the catalytic SET domain (Kd of 370 nM). Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: Solid. CAS No. 383907-43-5. Molecular formula: C15H16ClN3O3. Mole weight: 321.762. Purity: >99 %. Canonical SMILES: O=C(C(Cl)=C1NCCN2CCOCC2)C3=C(N=CC=C3)C1=O. Product ID: ACM383907435. Alfa Chemistry ISO 9001:2015 Certified.
NSC 663284
NSC 663284 (DA-3003-1) is a potent, cell-permeable, and irreversible Cdc25 dual specificity phosphatase inhibitor, has an IC50 for Cdc25B2 of 0.21 ?M. NSC 663284 exhibits mixed competitive kinetics against Cdc25A, Cdc25B(2), and Cdc25C with Ki values of 29, 95, and 89 nM, respectively[1]. NSC 663284 inhibits NSD2 (IC50 of 170 nM) through a direct interaction with the catalytic SET domain (Kd of 370 nM)[2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DA-3003-1. CAS No. 383907-43-5. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100034.
NSC 663284
NSC 663284. Group: Biochemicals. Grades: Purified. CAS No. 383907-43-5. Pack Sizes: 10mg. US Biological Life Sciences.
NSC 66811. Group: Biochemicals. Grades: Purified. CAS No. 6964-62-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
NSC668394
NSC668394 is a potent ezrin (Thr567) phosphorylation inhibitor, with a Kd of 12.59 ?M. NSC668394 inhibit ezrin T567 phosphorylation caused by PKC? primarily via their binding to ezrin. NSC668394 can be used to prevent tumor metastasis[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 382605-72-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115492.
Cell-permeable. Abrogates the deubiquitinating activity of the 19S regulatory particle by inhibiting ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14) resulting in accumulation of polyubiquitin in cells. NSC-687852 induces tumor cell apoptosis and tumor progression in four different solid tumor models in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 1009817-63-3. Pack Sizes: 5mg, 25mg. US Biological Life Sciences.
Worldwide
NSC689857
NSC689857 is a potent EGFR and SCFSKP2 inhibitor with an IC50 value of 36 ?M for Skp2-Cks1. NSC689857 can inhibit p27 ubiquitylation (IC50=30 ?M). NSC689857 has varied activity across cancer types, with more activity against leukemia cell lines than others[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 241127-79-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123578.
NSC 693868
NSC 693868. Group: Biochemicals. Grades: Purified. CAS No. 40254-90-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Selective Ub-conjugating enzyme (E2) complex Ubc13-Uev1A inhibitor. Inhibits the formation of the Ubc13~Ub conjugate. NF-kB activation inhibitor. Inhibits proliferation and survival of ABC-DLBCL and GCB-DLBCL (Diffuse large B cell lymphoma) cells. Group: Biochemicals. Alternative Names: 2-[(4-Methylphenyl)sulfonyl]-5-nitro-Furan, 2-Nitro-5-tosylfuran. Grades: Highly Purified. CAS No. 343351-67-7. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C??H?NO?S. US Biological Life Sciences.
Worldwide
NSC697923
NSC697923 is a potent UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13) inhibitor. NSC697923 induces neuroblastoma (NB) cell death via promoting nuclear importation of p53 in p53 wild-type NB cells. NSC697923 also induces cell death in p53 mutant NB cells by activation of JNK-mediated apoptotic pathway. NSC697923 inhibits DNA damage and NF-?B signaling. Antitumor activity[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 343351-67-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13811.
NSC 697923
NSC 697923. Group: Biochemicals. Grades: Purified. CAS No. 343351-67-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.