A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
NS-2028 is a highly selective soluble Guanylyl Cyclase (sGC) inhibitor with IC50 values of 30 nM and 200 nM for basal and NO-stimulated enzyme activity[1]. NS-2028 inhibits soluble Guanylyl Cyclase activity in homogenates of mouse cerebellum and neuronal NO synthase with IC50 values of 17 nM and 20 nM[1]. NS-2028 inhibits 3-morpholino-sydnonimine (SIN-1)-elicited formation of cyclic GMP in human cultured umbilical vein endothelial cells with an IC50 of 30 nM[1]. NS-2028 is commonly used in the research of nitric oxide signaling pathways, it inhibits NO-dependent relaxant responses in non-vascular smooth muscle completely (1 ?M)[1]. NS-2028 reduces vascular endothelial growth factor-induced angiogenesis and permeability[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 204326-43-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12379.
NS2B/NS3-IN-2
NS2B/NS3-IN-2 is a potent dengue virus (DENV) NS2B/NS3 covalent inhibitor with an IC50 of 6.0 nM and Ki of 0.66 μM. NS2B/NS3-IN-2 shows no cytotoxicity and markedly increases the cell survival rate[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3010940-08-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144612.
A useful ligand for incorporation of EDTA-metal complexes into proteins particularly for investigating orientation of DNA binding proteins. Group: Biochemicals. Grades: Purified. CAS No. 143541-95-1. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
N-[S-(2-Pyridylthioethyl)-t-boc-aminooxyacetamide
N-[S-(2-Pyridylthioethyl)-t-boc-aminooxyacetamide. Group: Biochemicals. Alternative Names: Boc-aoa-NH-(CH2)2-S-S-pyr. Grades: Highly Purified. CAS No. 887407-46-7. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C15H22N2O4S2. US Biological Life Sciences.
NS 3763. Group: Biochemicals. Grades: Purified. CAS No. 70553-45-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
NS383
NS383 is a potent and uniquely selective inhibitor of rat ASICs containing 1a and/or 3 subunits. NS383 inhibits H(+)-activated currents recorded from rat homomeric ASIC1a, ASIC3, and heteromeric ASIC1a+3 with IC 50 values ranging from 0.61 to 2.2 μM. NS383 is well tolerated and capable of reversing pathological painlike behaviors, presumably via peripheral actions, but possibly also via actions within central pain circuits [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 309711-59-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-131879.
NS3861 is an agonist of nicotinic acetylcholine receptors ( nAChRs ) and binds with high affinity to heteromeric α3β4 nAChR. The binding K i values of 0.62, 25, 7.8, 55 nM for α3β4, α3β2, α4β4, α4β2, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 216853-59-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110121A.
NS3861 fumarate
NS3861 fumarate is an agonist of nicotinic acetylcholine receptors ( nAChRs ) and binds with high affinity to heteromeric α3β4 nAChR. The binding K i values of 0.62, 25, 7.8, 55 nM for α3β4, α3β2, α4β4, α4β2, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 216853-60-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110121.
NS 398
NS 398. Group: Biochemicals. Grades: Purified. CAS No. 123653-11-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
NS-398 is a non-steroidal an-inflammatory agent with analgesic and antipyretic effects, and selectively inhibits prostaglandin G/H synthase 2/cyclooxygenase 2 ( COX-2 ) activity, with an IC 50 of 3.8 μM, and has no effect on COX-1 at 100 μM. Uses: Scientific research. Group: Signaling pathways. CAS No. 123653-11-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13913.
NS-398 - CAS 123653-11-2
A cell-permeable selective inhibitor of COX-2 in vitro. Group: Fluorescence/luminescence spectroscopy.
NS-398 (NS398, NS 398)
NS-398 (NS398, NS 398). Group: Biochemicals. Alternative Names: N- (2-cyclohexyloxy-4-nitrophenyl) methanesulfonamide. Grades: Highly Purified. CAS No. 123653-11-2. Pack Sizes: 50mg. Molecular Formula: C13 H18 N2O5, Molecular Weight: 314.4. US Biological Life Sciences.
Worldwide
NS-5
NS-5 is a beta-lactam antibiotic produced by Streptomyces cattaleya. It inhibits gram-positive, gram-negative bacteria and beta-lactamase. Molecular formula: C11H16N2O3S. Mole weight: 256.32.
NS 6180. Group: Biochemicals. Grades: Purified. CAS No. 353262-04-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
NS8593
An aminobenzimidazole derivative that selectively and reversibly blocks small conductance Ca2+-activated K+ channels in a Ca2+-dependent manner. Group: Fluorescence/luminescence spectroscopy.
NS8593 hydrochloride is a potent and selective small conductance Ca 2+ -activated K + channels (SK channels) inhibitor. NS8593 hydrochloride reversibly inhibits SK3 -mediated currents with a K d value of 77 nM. NS8593 hydrochloride inhibits all the SK1-3 subtypes Ca 2+ -dependently ( K d s of 0.42, 0.60, and 0.73 μM, respectively, at 0.5 μM Ca 2+ ), and does not affect the Ca 2+ -activated K + channels of intermediate and large conductance (hIK and hBK channels, respectively) [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 875755-24-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-110105.
An aminobenzimidazole derivative that selectively and reversibly blocks small conductance Ca2+-activated K+ channels (SK1-3; =420nM, 600nM, and 730nM for SK1, SK2, SK3, respectively) in a Ca2+-dependent manner. It mediates channel gating by interacting with gating structures deep within the inner pore vestibule where Ser507 and Ala532 are deemed to be important for inhibition. Interacts at a site that is distinct from the apamin binding site in SK channels. Can access high-affinity binding sites from both the inside and outside of the cell membrane. Does not affect QT intervals, but prolongs the atrial effective refractive period and prevents acetylcholine-induced atrial fibrillations in ex vivo and in vivo models. Also shown to reversibly block TRPM7 channel (IC50=1.6mM) in smooth muscle cells, primary podocytes, HEK293 cells expressing TRPM7, and ventricular myocytes in a Mg2+-dependent manner and blocks the motility of cells in culture. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
NS 9283
NS 9283. Group: Biochemicals. Grades: Purified. CAS No. 913830-15-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
NSAH
NSAH is a reversible and competitive nonnucleoside ribonucleotide reductase (RR) inhibitor, with cell-free IC 50 of 32 μM and cell-based IC 50 of ~250 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1099592-35-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114503.
N-Salicylideneaniline
N-Salicylideneaniline. Group: Biochemicals. Alternative Names: N-Salicylalaniline. Grades: Highly Purified. CAS No. 779-84-0. Pack Sizes: 10g, 25g, 50g, 100g, 250g. US Biological Life Sciences.
Worldwide
N-Salicylidene p-bromoaniline
N-Salicylidene p-bromoaniline. Uses: Designed for use in research and industrial production. Additional or Alternative Names: SALICYLIDENE-(P-BROMOANIL);SALICYLIDENE P-BROMOANILINE;TIMTEC-BB SBB007908;O-[N-(P-BROMOPHENYL)FORMIMIDOYL]PHENOL;N-SALICYLIDENE P-BROMOANILINE;2-(((4-bromophenyl)imino)methyl)-pheno;2-(((4-bromophenyl)imino)methyl)phenol;2-((E)-[(4-Bromophenyl)imino]met. Product Category: Heterocyclic Organic Compound. CAS No. 886-34-0. Molecular formula: C13H10BrNO. Mole weight: 276.13. Purity: 0.96. IUPACName: 6-[(4-bromoanilino)methylidene]cyclohexa-2,4-dien-1-one. Canonical SMILES: C1=CC(=CNC2=CC=C(C=C2)Br)C(=O)C=C1. Density: 1.385g/cm³. Product ID: ACM886340. Alfa Chemistry ISO 9001:2015 Certified.
N-Salicyloyltryptamine acts on voltage-dependent Na + , Ca 2+ , and K + ion channels inhibitor. N-Salicyloyltryptamine inhibits K + currents with an IC 50 value of 34.6 μM ( I to ). N-Salicyloyltryptamine also exhibits anticonvulsant, anti-inflammatory, analgesic, and vasorelaxation effect [1] - [5]. Uses: Scientific research. Group: Signaling pathways. CAS No. 31384-98-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-147377.
NSC 107512
NSC 107512 is a potent inhibitor of cyclin-dependent kinase 9 (CDK9). NSC 107512 is a class of sangivamycin-like molecules (SLM). NSC 107512 inhibits growth and induces apoptosis of multiple myeloma tumors[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 22242-89-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-141687.
NSC16168 is a specific inhibitor of ERCC1-XPF, with an IC50 value of 0.42 ?M. NSC16168 inhibits DNA repair and potentiates CDDP efficacy in cancer[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 6837-93-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-100690.
NSC 177223. Group: Biochemicals. Alternative Names: 4-Amino-5,8-dihydro-5-oxo-8- β-D-ribofuranosyl-pyrido[2,3-d]pyrimidine-6-carboxamide; API-1. Grades: Highly Purified. CAS No. 36707-00-3. Pack Sizes: 5mg. Molecular Formula: C13H15N5O6, Molecular Weight: 337.29. US Biological Life Sciences.
Worldwide
NSC 185058
NSC 185058 is an inhibitor of ATG4B, a major cysteine protease. Inhibition of ATG4B using NSC 185058 markedly attenuates autophagic activity[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 39122-38-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-125169.
NSC 194308
NSC 194308, a U2AF2-RNA complexes enhancer, increases association of the U2AF1-U2AF2-SF1-splice site RNA complex by binding a site between the U2AF2 RNA recognition motifs (RRM1 and RRM2). NSC 194308 inhibits pre-mRNA splicing by stalling spliceosome assembly at the point where U2AF helps recruit U2 snRNP to the branchpoint. NSC 194308 enhances the binding of pre-mRNA to U2AF2, selectively triggering cell death in leukemia cell lines containing spliceosome mutations[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 90379-42-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-153736.
NSC 228155
NSC 228155 is an activator of EGFR, binds to the extracellular region of EGFR and enhance tyrosine phosphorylation of EGFR[1]. NSC 228155 is also a potent inhibitor of KIX-KID interaction, inhibits kinase-inducible domain (KID) from CREB and KID-interacting domain (KIX) from CBP, with an IC50 of 0.36 ?M[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 113104-25-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101084.
NSC 23005 Sodium Salt
NSC 23005 Sodium Salt is used to perpare sodium sodium cyclohexyl aminosulfonyl benzoate as p18 micromolecule inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 1796596-46-7. Pack Sizes: 1mg, 5mg. Molecular Formula: C13H16NNaO4S, Molecular Weight: 305.33. US Biological Life Sciences.
Worldwide
NSC232003
NSC232003 is a highly potent and cell-permeable UHRF1 inhibitor, which inhibits DNA methylation in vitro and disrupts DNMT1/UHRF1 interactions at a cellular level. Uses: Scientific research. Group: Signaling pathways. CAS No. 1905453-18-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-103236.
NSC 23766
NSC 23766 is a cell-permeable, reversible and specific inhibitor of Rac GTPase, used for cancer treatment. Uses: Scientific research. Group: Signaling pathways. CAS No. 733767-34-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15723.
NSC 23766 trihydrochloride
NSC 23766 trihydrochloride is an inhibitor of Rac1 activation. Uses: Scientific research. Group: Signaling pathways. CAS No. 1177865-17-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15723A.
NSC23925 is a novel, selective and effective P-glycoprotein ( Pgp ) inhibitor. Uses: Scientific research. Group: Signaling pathways. CAS No. 858474-14-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-19626.
NSC 245214
NSC 245214 is a thienyl cycloalkanone that is part of the US National Cancer Institute small molecule repository. The biological activity of this compound has not been reported. Group: Biochemicals. Alternative Names: 2-(3,5-dinitro-2-thienyl)-cyclohexanone. Grades: Highly Purified. CAS No. 31554-45-7. Pack Sizes: 1mg, 5mg, 10mg, 25mg. Molecular Formula: C10H10N2O5S, Form: Supplied as a crystalline. US Biological Life Sciences.
NSC 280449 is a derivative of Tromethamine (T892600); a compound that is widely used in biochemistry and molecular biology. In medicine, Tromethamine is used as an alternative to sodium bicarbonate in the treatment of metabolic acidosis. Group: Biochemicals. Grades: Highly Purified. CAS No. 60204-53-7. Pack Sizes: 100mg, 500mg. Molecular Formula: C10H17NO3, Molecular Weight: 199.25. US Biological Life Sciences.
Worldwide
NSC2805
NSC2805 is a WWP2 ubiquitin ligase inhibitor that can significant inhibit WWP2 activity with an IC50 of 0.38 ?M. NSC2805 can be used for the research of cancer[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 4371-34-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134417.
NSC 295642
NSC 295642. Uses: Designed for use in research and industrial production. Additional or Alternative Names: NSC 295642, [1-(2-pyridinyl)ethylidene]-Hydrazinecarbodithioic acid, phenylmethyl ester, copper complex, 77111-29-6, Bis-[chloro[phenylmethyl [1-(2-pyridinyl)ethylidene]hydrazinecarbodithioato-N2,N2 inverted exclamation marka,S1 inverted exclamation mark ]-copper], Cu(II) complex of the Schiff base product of condensation of S-benzyl dithiocarbazate and 2-acetylpyridine. Product Category: Heterocyclic Organic Compound. CAS No. 77111-29-6. Molecular formula: C15H14ClCuN3S2. Mole weight: 798.84. Purity: 0.96. IUPACName: (E)-benzylsulfanyl-[(E)-1-pyridin-2-ylethylidenehydrazinylidene]-sulfidomethane;chlorocopper(1+). Canonical SMILES: CC(=NN=C([S-])SCC1=CC=CC=C1)C2=CC=CC=N2.Cl[Cu+]. Product ID: ACM77111296. Alfa Chemistry ISO 9001:2015 Certified. Categories: DTXSID20444568.