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| Product | Description | |
|---|---|---|
| NVP-BSK805 | NVP-BSK805, a quinoxaline derivative, is a selective ATP-competitive JAK2 inhibitor which could induce apoptosis (GI50 < 100 nM) and restrain the growth of JAK2V617F cells (Ba/F3). Synonyms: 4-(2,6-difluoro-4-(3-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)quinoxalin-5-yl)benzyl)morpholine; BSK 805; 8-[3,5-difluoro-4-(morpholin-4-ylmethyl)phenyl]-2-(1-piperidin-4-yl-1H-pyrazol-4-yl)quinoxaline. Grades: 98%. CAS No. 1092499-93-8. Molecular formula: C27H28F2N6O. Mole weight: 490.55. |  |
| NVP-BVU972 | NVP-BVU972 potently inhibits MET kinase but displays low inhibition against other kinases including the most closely related kinase RON with IC50 values of more than 1000 nM. Synonyms: NVP BVU972; NVPBVU972; NVP-BVU972; BVU-972; BVU 972; BVU972. Grades: >98%. CAS No. 1185763-69-2. Molecular formula: C20H16N6. Mole weight: 340.38. | |
| NVP-CGM097 | NVP-CGM097 is a potent and selective MDM2 inhibitor with IC 50 of 1.7±0.1 nM for hMDM2. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CGM097. CAS No. 1313363-54-0. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15954. |  |
| NVP-CGM097 sulfate | NVP-CGM097 sulfate is a potent and selective MDM2 inhibitor with IC 50 of 1.7±0.1 nM for hMDM2. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CGM097 sulfate. CAS No. 1313367-56-4. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15954B. | |
| NVP-CGM097 sulfate | NVP-CGM097 sulfate, a dihydroisoquinolinone derivative, is a potent and selective MDM2 inhibitor (IC50 = 1.7±0.1 nM for hMDM2) in the treatment of p53wt tumors. Synonyms: (1S)-1-(4-chlorophenyl)-6-methoxy-2-[4-[methyl-[[4-(4-methyl-3-oxopiperazin-1-yl)cyclohexyl]methyl]amino]phenyl]-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one;sulfuric acid; NVP-CGM097 (sulfate). CAS No. 1313367-56-4. Molecular formula: C38H49ClN4O8S. Mole weight: 757.34. | |
| NVP CXCR2 20 | NVP CXCR2 20 is a potent and selective CXCR2 antagonist. Synonyms: 4-Cyclopropyl-2-[[(2,3-difluorophenyl)methyl]thio]-1,6-dihydro-6-oxo5-pyrimidinecarbonitrile; NVP-CXCR2 20; NVP CXCR2-20; NVP CXCR220. CAS No. 1029521-30-9. Molecular formula: C15H11F2N3OS. Mole weight: 319.33. | |
| NVP-DFF332 | HIF-2α-IN-8 is a potent and orally active HIF2α inhibitor with IC 50 values of 9, 37, 246 nM for HIF2α SPA, HIF2α iScript, HIF2α HRE RGA, respectively. HIF-2α-IN-8 shows antitumor activity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: HIF-2α-IN-8. CAS No. 2734922-78-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-148860. | |
| NVP DPP 728 dihydrochloride | NVP DPP 728 dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 207556-62-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| NVP DPP 728 dihydrochloride | NVP DPP 728, a cyanopyrrolidine, is a potent, orally active dipeptidyl peptidase (DPP)-IV inhibitor with excellent oral bioavailability and potent antihyperglycemic activity (Ki = 11 nM, IC50=14 nM). NVP DPP 728 exhibits > 15 000-fold selectivity over DPP-II and a range of proline-cleaving proteases. Synonyms: NVP DPP 728 dihydrochloride; NVPDPP728 dihydrochloride; NVP-DPP-728 dihydrochloride; 6-[[2-[[2-(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethyl]amino]ethyl]amino-3-pyridinecarbononitrile dihydrochloride. Grades: ≥97% by HPLC. CAS No. 207556-62-5. Molecular formula: C15H18N6O.2HCl. Mole weight: 371.27. | |
| NVP-HDM201 | NVP-HDM201 (HDM201) is a potent and highly specific MDM-2/p53 inhibitor that binds to human Mdm2 protein with a sub-nanomolar Ki value, activates p53 and induces robust p53-dependent cell cycle arrest and apoptosis in human p53 wild-type tumor cells. Synonyms: Siremadlin; HDM201; HDM 201; HDM-201; NVP-HDM-201; NVP-HDM 201. CAS No. 1448867-41-1. Molecular formula: C26H24Cl2N6O4. Mole weight: 555.41. | |
| NVP-LCQ195 | NVP-LCQ195 is a small molecule heterocyclic inhibitor of CDK1, CDK2, CDK3 and CDK5. It induced cell cycle arrest and eventual apoptotic cell death of MM cells, even at sub-lmol/l concentrations, spared non-malignant cells, and overcame the protection conferred to MM cells by stroma or cytokines of the bone marrow milieu. It suppressed the expression of transcription factors including myc, IRF4 and XBP-1. Synonyms: NVP-LCQ-195; NVP-LCQ 195; NVP-LCQ195. LCQ-195; LCQ 195; LCQ195; AT9311; AT-9311; AT 9311. Grades: >98%. CAS No. 902156-99-4. Molecular formula: C17H19Cl2N5O4S. Mole weight: 460.33. | |
| NVP-QAV-572 | NVP-QAV-572 is a potent PI3K kianse inhibitor. Grades: >98%. CAS No. 957209-68-6. Molecular formula: C17H19F2N7O3S2. Mole weight: 471.5. | |
| NVP-QAV680 | NVP-QAV680 is a potent and selective CRTh2 receptor antagonist with Ki of 36 nM by 3H-PGD2 filtration binding assay. Synonyms: QAV-690 free acid; QAV690 free acid; QAV 690 free acid; NVP-QAV680; NVP ; NVPQAV680; NVP-QAV-680. Grades: >98%. CAS No. 872365-16-7. Molecular formula: C18H18N2O4S. Mole weight: 358.41. | |
| NVP-TNKS656 | NVP-TNKS656 is a highly potent, selective, and orally active TNKS2 inhibitor with IC 50 of 6 nM, and is > 300 fold selectivity against PARP1 and PARP2. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TNKS656. CAS No. 1419949-20-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13990. | |
| NVR 3-778 | NVR 3-778 is the first capsid assembly modulator (CAM) that has demonstrated antiviral activity in hepatitis B virus (HBV)-infected patients. NVR 3-778 inhibited the generation of infectious HBV DNA-containing virus particles with a mean antiviral 50% effective concentration (EC50) of 0.40?μM in HepG2.2.15 cells. The antiviral profile of NVR 3-778 indicates pan-genotypic antiviral activity and a lack of cross-resistance with nucleos(t)ide inhibitors of HBV replication. Group: Inhibitors. Alternative Names: NVR 3 778; NVR3 778; NVR-3-778; K-89; K 89; K89; NVR3778; NVR 3778; NVR-3778. CAS No. 1445790-55-5. Molecular formula: C18H16F4N2O4S. Mole weight: 432.39. Appearance: Solid powder. Purity: >98%. IUPACName: 4-Fluoro-3-((4-hydroxypiperidin-1-yl)sulfonyl)-N-(3,4,5-trifluorophenyl)benzamide. Canonical SMILES: O=C (NC1=CC (F)=C (F)C (F)=C1)C2=CC=C (F)C (S (=O) (N3CCC (O)CC3)=O)=C2. Catalog: ACM1445790555. |  |
| NVS-CECR2-1 | NVS-CECR2-1, a non-BET family Bromodomain (BRD) inhibitor, is a potent and selective cat eye syndrome chromosome region, candidate 2 ( CECR2 ) inhibitor. NVS-CECR2-1 binds to CECR2 BRD with high affinity ( IC 50 =47 nM; K D =80 nM). NVS-CECR2-1 exhibits cytotoxic activity and induces apoptosis against various cancer cells by targeting CECR2 as well as via CECR2-independent mechanism [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1992047-61-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110374. | |
| NVS-CECR2-1 | NVS-CECR2-1 is a potent and selective CECR2 (cat eye syndrome chromosome region, candidate 2) inhibitor (IC50 = 47 nM). NVS-CECR2-1 showed no cross reactivity in a BRD panel of 48 targets or any major activity in kinase, protease and receptor panels. CECR2 (cat eye syndrome chromosome region, candidate 2) is a component of chromatin complexes that regulate gene expression controlling development. Synonyms: NVS-CECR2-1; NVS CECR2 1; NVSCECR21; NVS-1; NVS 1; NVS1; N-Cyclopropyl-2-(propylsulfonyl)-6-(1-(2,2,6,6-tetramethylpiperidin-4-yl)-1H-indol-5-yl)pyrimidin-4-amine. Grades: ≥98% by HPLC. CAS No. 1992047-61-6. Molecular formula: C27H37N5O2S. Mole weight: 495.68. | |
| NVS-CRF38 | NVS-CRF38 is a novel corticotropin-releasing factor receptor 1 (CRF1) antagonist with low water solubility. Synonyms: NVS-CRF 38; NVS-CRF-38. Grades: >98%. CAS No. 1207258-55-6. Molecular formula: C19H21N5O2. Mole weight: 351.4. | |
| NVS-PAK1-1 | NVS-PAK1-1 is a specific allosteric PAK1 inhibitor. Group: Inhibitors. Alternative Names: NVS-PAK1-1; NVSPAK11; NVS PAK1 1. CAS No. 1783816-74-9. Molecular formula: C23H25ClF3N5O. Mole weight: 479.93. Appearance: Solid powder. Purity: >98%. IUPACName: 3(S)-[2-Chloro-5-(2,2-difluoro-ethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-ylamino]-pyrrolidine-1-carboxylic acid isopropylamide. Canonical SMILES: O=C (N1C[C@@H] (NC2=NC3=CC (F)=CC=C3N (CC (F)F)C4=CC=C (Cl)C=C42)CC1)NC (C)C. Catalog: ACM1783816749. | |
| NVS-PAK1-1 | NVS-PAK1-1 is potent and specific allosteric PAK1 inhibitor (IC50 = 5 nM) with selective over PAK2 and a panel of 442 kinases. Synonyms: NVS-PAK1-1; NVSPAK11; NVS PAK1 1; (3S)-3-[[8-chloro-11-(2,2-difluoroethyl)-3-fluorobenzo[b][1,4]benzodiazepin-6-yl]amino]-N-propan-2-ylpyrrolidine-1-carboxamide. CAS No. 1783816-74-9. Molecular formula: C23H25ClF3N5O. Mole weight: 479.93. | |
| NVS-PAK1-1 | NVS-PAK1-1 is a potent and selective allosteric PAK1 inhibitor with an IC 50 of 5 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1783816-74-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100519. | |
| NVS PAK1 C | NVS PAK1 C is the negative control of NVS PAK1 1. NVS PAK1 1 is a potent and selective PAK1 inhibitor (IC50 = 5 nM). Selective for PAK1 over PAK2 and a panel of 442 kinases. Synonyms: (3S)-3-(2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-ylamino)-N,N-dimethylpyrrolidine-1-carboxamide. Grades: ≥98% by HPLC. CAS No. 2250019-95-3. Molecular formula: C22H23ClF3N5O. Mole weight: 465.91. | |
| NVS-PAK1-C | NVS-PAK1-C is a potent, ATP-competitive and specific allosteric PAK1 inhibitor probe with IC 50 values of 5 nM and 6 nM for dephosphorylated PAK1 and phosphorylated PAK1, respectively. NVS-PAK1-C is also against dephosphorylated PAK2 ( IC 50 =270 nM) and phosphorylated PAK2 ( IC 50 =720 nM) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2250019-95-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-131043. | |
| NVS-ZP7-4 | NVS-ZP7-4 inhibits Notch signaling with IC50 of 0.13 uM in HES-Luc reporter gene assays, selectively induces apoptosis and ER stress. NVS-ZP7-4 is the first reported chemical tool to probe the impact of modulating ER zinc levels and investigate ZIP7 as a novel druggable node in the Notch pathway. Group: Fluorinated apis. Alternative Names: 1'-[(2S)-2-[(6-fluoro-1,3-benzothiazol-2-yl)amino]-3-phenylpropyl]spiro[1,3-dihydroquinazoline-4,4'-piperidine]-2-one. CAS No. 2349367-89-9. Molecular formula: C28H28FN5OS. Mole weight: 501.62. Appearance: White to off-white solid powder. Purity: >98%. IUPACName: 1'-[(2S)-2-[(6-fluoro-1,3-benzothiazol-2-yl)amino]-3-phenylpropyl]spiro[1,3-dihydroquinazoline-4,4'-piperidine]-2-one. Catalog: OFC2349367899. | |
| Nw- (2, 2, 4, 6, 7-Penta methyl dihydrobenzofuran) -5-sulfonyl-D-arginine | Nw- (2, 2, 4, 6, 7-Penta methyl dihydrobenzofuran) -5-sulfonyl-D-arginine. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 250mg, 1g, 5g. US Biological Life Sciences. | Worldwide |
| Nw- (2, 2, 4, 6, 7-Penta methyl dihydrobenzofuran-5-sulfonyl) -L-arginine 99+% (HPLC) | Nw- (2, 2, 4, 6, 7-Penta methyl dihydrobenzofuran-5-sulfonyl) -L-arginine 99+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g. US Biological Life Sciences. | Worldwide |
| Nw- (2, 2, 4, 6, 7-Penta methyl dihydrobenzofuran-5-sulfonyl) -L-arginine allyl ester hydrochloride ≥95% (HPLC) | Nw- (2, 2, 4, 6, 7-Penta methyl dihydrobenzofuran-5-sulfonyl) -L-arginine allyl ester hydrochloride ≥95% (HPLC). Group: Biochemicals. Grades: Reagent Grade. CAS No. 257288-23-6. Pack Sizes: 1g, 5g, 25g. US Biological Life Sciences. | Worldwide |
| Nw- (2, 2, 4, 6, 7-Penta methyl dihydrobenzofuran-5-sulfonyl) -L-arginine methyl ester hydrochloride 99+% (TLC) | Nw- (2, 2, 4, 6, 7-Penta methyl dihydrobenzofuran-5-sulfonyl) -L-arginine methyl ester hydrochloride 99+% (TLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g. US Biological Life Sciences. | Worldwide |
| Nw-(2,2,5,7,8-Pentamethylchroman-6-sulfonyl)-D-arginine | Nw-(2,2,5,7,8-Pentamethylchroman-6-sulfonyl)-D-arginine. Group: Biochemicals. Alternative Names: D-Arg(Pmc)-OH. Grades: Highly Purified. CAS No. 191869-60-0. Pack Sizes: 500mg, 1g, 2g, 5g. US Biological Life Sciences. | Worldwide |
| Nw-(2,2,5,7,8-Pentamethylchroman-6-sulfonyl)-D-arginine-2-chlorotrityl resin | Nw-(2,2,5,7,8-Pentamethylchroman-6-sulfonyl)-D-arginine-2-chlorotrityl resin. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g. US Biological Life Sciences. | Worldwide |
| Nw-(2,2,5,7,8-Pentamethylchroman-6-sulfonyl)-D-arginine 98+% (TLC) | Nw-(2,2,5,7,8-Pentamethylchroman-6-sulfonyl)-D-arginine 98+% (TLC). Group: Biochemicals. Grades: Reagent Grade. CAS No. 191869-60-0. Pack Sizes: 1g, 5g. US Biological Life Sciences. | Worldwide |
| Nw-(2,2,5,7,8-Pentamethylchroman-6-sulfonyl)-L-arginine | Nw-(2,2,5,7,8-Pentamethylchroman-6-sulfonyl)-L-arginine. Group: Biochemicals. Alternative Names: L-Arg(Pmc)-OH. Grades: Highly Purified. CAS No. 112160-37-9. Pack Sizes: 1g, 2g, 5g, 10g, 25g. US Biological Life Sciences. | Worldwide |
| Nw-(2,2,5,7,8-Pentamethylchroman-6-sulfonyl)-L-arginine 99+% (TLC) | Nw-(2,2,5,7,8-Pentamethylchroman-6-sulfonyl)-L-arginine 99+% (TLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g. US Biological Life Sciences. | Worldwide |
| Nw-((2S,3S)-2-((Z)-2-(2-aminothiazol-4-yl)-2-(((2-carboxypropan-2-yl)oxy)imino)acetamido)-3-(sulfoamino)butanoyl)-L-arginine compound with formic acid (1:1) | It's one of Aztreonam impurities, Aztreonam is a monobactam antibiotic used primarily to treat gram-negative bacterial infections. Grades: 98%. Molecular formula: C19H31N9O10S2.CH2O2. Mole weight: 655.66. | |
| NW457 | NW-457 is a potent Hsp90 inhibitor with no detectable hepatocytotoxicity in vitro. It synergizes with ionizing irradiation to induce chromatin condensation, nuclear fragmentation, apoptosis, and post-apoptotic, secondary necrosis. Enhanced apoptosis induction by NW457 in combination with irradiation is accompanied by increased caspase activation and caspase substrate cleavage. Synonyms: NW457; NW 457; NW-457; 1H-2-Benzoxacyclotetradec?in-1,?11(12H)?-dione, 3,?4,?7,?8-tetrahydro-7,?14,?16-trihydroxy-3-methyl-, 11-[O-[2-oxo-2-(1-piperidinyl)?ethyl]?oxime]?, (3S,?5E,?9E,?11E)?-. Grades: >98%. CAS No. 1373761-12-6. Molecular formula: C25H32N2O7. Mole weight: 472.53. | |
| Nw- (4-Methoxy-2, 3, 6-trimethyl Benzene sulfonyl) -L-arginine 98+% (HPLC) | Nw- (4-Methoxy-2, 3, 6-trimethyl Benzene sulfonyl) -L-arginine 98+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g, 100g. US Biological Life Sciences. | Worldwide |
| Nw- (4-Methoxy-2, 3, 6-trimethyl Benzene sulfonyl) -L-arginine tert-butyl ester 99+% (TLC) | Nw- (4-Methoxy-2, 3, 6-trimethyl Benzene sulfonyl) -L-arginine tert-butyl ester 99+% (TLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 250mg, 1g. US Biological Life Sciences. | Worldwide |
| Nw-(4-Toluenesulfonyl)-D-arginine ≥97% (HPLC) | Nw-(4-Toluenesulfonyl)-D-arginine ≥97% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g. US Biological Life Sciences. | Worldwide |
| Nw-(4-Toluenesulfonyl)-L-arginine 98+% (HPLC) | Nw-(4-Toluenesulfonyl)-L-arginine 98+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. CAS No. 4353-32-6. Pack Sizes: 1g, 5g, 10g, 25g, 100g. US Biological Life Sciences. | Worldwide |
| N-w-Hydroxy-L-norarginine | N-w-Hydroxy-L-norarginine. Group: Biochemicals. Alternative Names: nor-NOHA; L-2-Amino-{4- (2'-hydroxyguanidino) butyric acid. Grades: Highly Purified. CAS No. 189302-40-7. Pack Sizes: 10mg, 25mg, 50mg, 100mg, 250mg. US Biological Life Sciences. | Worldwide |
| N-w-Hydroxy-L-norarginine diacetate salt | Synonyms: nor-NOHA diacetate; L-2-Amino-{4-(2'-hydroxyguanidino)butyric acid diacetate. Grades: ≥ 97% (TLC). CAS No. 189302-40-7. Molecular formula: C5H12N4O3·2C2H4O2. Mole weight: 296.278. | |
| N-w-Hydroxy-L-norarginine diacetate salt ≥97% (TLC) | N-w-Hydroxy-L-norarginine diacetate salt ≥97% (TLC). Group: Biochemicals. Grades: Reagent Grade. CAS No. 189302-40-7. Pack Sizes: 250mg, 25mg, 50mg, 1g. US Biological Life Sciences. | Worldwide |
| Nw-Methyl-L-arginine hydrochloride ≥95% (HPLC) | Nw-Methyl-L-arginine hydrochloride ≥95% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 50mg, 100mg, 250mg. US Biological Life Sciences. | Worldwide |
| Nw-Nitro-D-arginine 98+% (HPLC) | Nw-Nitro-D-arginine 98+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. CAS No. 66036-77-9. Pack Sizes: 5g, 25g, 100g, 250g. US Biological Life Sciences. | Worldwide |
| Nw-Nitro-D-arginine methyl ester hydrochloride 99+% (HPLC) | Nw-Nitro-D-arginine methyl ester hydrochloride 99+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. CAS No. 50912-92-0. Pack Sizes: 1g, 5g, 25g. US Biological Life Sciences. | Worldwide |
| Nw-Nitro-L-arginine 99+% | Nw-Nitro-L-arginine 99+%. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 25g, 100g, 250g, 1Kg. US Biological Life Sciences. | Worldwide |
| Nw-Nitro-L-arginine methyl ester hydrochloride | Nw-Nitro-L-arginine methyl ester hydrochloride. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 5g, 25g, 100g, 250g. US Biological Life Sciences. | Worldwide |
| Nw,Nw'-Di-Z-L-arginine | Nw,Nw'-Di-Z-L-arginine. Group: Biochemicals. Grades: Reagent Grade. CAS No. 4125-79-5. Pack Sizes: 250mg, 1g, 5g, 25g. US Biological Life Sciences. | Worldwide |
| Nw-Propyl-L-Arginine | A highly selective competitive inhibitor and inactivator of all three isoforms of NOS. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| NX-1607 | NX-1607 (Compound 23) is an inhibitor of Cbl-b , an E3 enzyme in the ubiquitin-proteasome pathway, with an IC 50 value of less than 1 nM. NX-1607 can be used in cancer research [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Cbl-b-IN-3. CAS No. 2573775-59-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141432. | |
| NX-2127 | NX-2127 (compound 28) is an orally active PROTAC deggrader, targeting to Brutons Tyrosine Kinase (Btk). NX-2127 inhibits proliferation of BTK C481S mutant TMD8 cells, more effectively than Ibrutinib (HY-10997). NX-2127 catalyzes the degradation of Ikaros (IKZF1) and Aiolos (IKZF3) with of 25 nM and 54 nM, respectively. NX-2127 stimulates T cell activation and increases IL-2 production in primary human T Cells [1] [2]. NX-2127 is composed of PROTAC target protein ligand (red part) BTK ligand 10 (HY-168302), E3 ligase ligand (blue part) Thalidomide 5-fluoride (HY-W087383) and PROTAC Linker (black part) (S)-4-(1-(Pyrrolidin-3-ylmethyl)piperidin-4-yl)aniline (HY-168303). Among which, the conjugate of E3 ubiquitin ligase ligand + Linker compose of Thalidomide-pyrrolidine-C-piperidine-Ph-NH2 (HY-168304). Uses: Scientific research. Group: Signaling pathways. CAS No. 2416131-46-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153220. | |
| NX-5948 | NX-5948 (BTK-IN-24) is an orally active chimeric targeting molecule (CTM) that induces specific BTK protein degradation by the cereblon E3 ligase (CRBN) complex without degradation of other cereblon neo-substrates. NX-5948 mediates potent anti-inflammatory activity via BTK degradation with resultant inhibition of B cell activation. NX-5948 exhibits potent tumor growth inhibition in TMD8 xenograft models that contain either wild-type BTK or BTKi-resistant mutations. NX-5948 is efficacious in a mouse collageninduced arthritis (CIA) model. NX-5948 can cross the blood brain barrier (BBB). NX-5948 is a PROTAC composed of the ligand for target protein, a linker, and a cereblon E3 ligase (CRBN) complex (Red: ligand for target protein; Blue: CRBN; Black: linker) [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BTK-IN-24. CAS No. 2649400-34-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-153321. | |
| N-XantPhos | A large bite-angle chelating bisphosphine that provides high levels of linear-to-branched selectivity in the hydroformylation of alkenes. A Deprotonatable Ligand for Room-Temperature Palladium-Catalyzed Cross-Couplings of Aryl Chlorides. Group: Heterocyclic organic compound. Alternative Names: Bis(diphenylphosphino)phenoxazine; DTXSID70390703; TRA0045396; 4,6-bis(diphenylphosphino)-phenoxazine; N-XantPhos, 97%; BB0294709; B2717; 4,6-Bis(diphenylphosphino)phenoxazine; 10H-Phenoxazine, 4,6-bis(diphenylphosphino)-; DB-009532. CAS No. 261733-18-0. Molecular formula: C36H27NOP2. Mole weight: 551.566g/mol. IUPACName: (6-diphenylphosphanyl-10H-phenoxazin-4-yl)-diphenylphosphane. Canonical SMILES: C1=CC=C (C=C1)P (C2=CC=CC=C2)C3=CC=CC4=C3OC5=C (N4)C=CC=C5P (C6=CC=CC=C6)C7=CC=CC=C7. Catalog: ACM261733180. | |
| NXD30001 | NXD30001 inhibits Hsp90, potentially resulting in decreased tumor growth. Synonyms: NXD30001; NXD 30001; NXD-30001. Grades: >98%. CAS No. 1223580-83-3. | |
| Nxl 104 | Heterocyclic Organic Compound. Alternative Names: AvibactaM SodiuM Salt;NXL 104;Sulfuric AcidMono[(1R,2S,5R)-2-(aMinocarbonyl)-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl] EsterSodiuM Salt;Avibactam (sodium);AvibactaM SodiuM NXL 104;sodium (1R,2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl sulfate;(2S,5R)-7-Oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide monosodium salt. CAS No. 1192491-61-4. Molecular formula: C7H10N3NaO6S. Mole weight: 287.22557. Catalog: ACM1192491614. | |
| NXP800 | NXP800 (CCT361814) is a potent and orally active heat shock factor 1 (HSF1) pathway inhibitor. NXP800 has the potential for cancer research [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CCT361814. CAS No. 1693734-80-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145927. | |
| NXY 059 | NXY 059. Group: Biochemicals. Grades: Purified. CAS No. 168021-79-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| NYAD-1 | NYAD-1 is a cell-penetrating alpha-helical peptide that is used as a potential HIV-1 inhibitor. The hydrocarbon-stapled structure enhances alpha helicity. Synonyms: H-Ile-Thr-Phe-X-Asp-Leu-Leu-X-Tyr-Tyr-Gly-Pro-NH2. Grades: ≥95%. Mole weight: 1450.70. | |
| Nyasicol | Phenols. CAS No. 111518-95-7. Molecular formula: C17H16O6. Mole weight: 316.3. Appearance: Oil. Purity: 0.98. IUPACName: 4-[(4R,5R)-5-(3,4-dihydroxyphenyl)-4,5-dihydroxypent-1-ynyl]benzene-1,2-diol. Canonical SMILES: C1=CC (=C (C=C1C#CCC (C (C2=CC (=C (C=C2)O)O)O)O)O)O. Catalog: ACM111518957. | |
| Nybomycin | An unusual heterocyclic metabolite isolated from several streptomyces species; possesses antiviral and antibacterial activity. Synonyms: NSC613948; 8-(Hydroxymethyl)-6,11-dimethyl-2H,4H-oxazolo[5,4,3-ij]pyrido[3,2-g]quinoline-4,10(11H)-dione; 8,9-Dihydro-4-(hydroxymethyl)-6,9-dimethyl-2,8-dioxopyrido(3,2-g)quinoline-1(2H)-carboxaldehyde. Grades: >95% by HPLC. CAS No. 30408-30-1. Molecular formula: C16H14N2O4. Mole weight: 298.29. | |
| Nybomycin | Nybomycin, an antibiotic, exhibits antiphage and antibacterial properties. Nybomycin binds to DNA and induces a unique morphological change to mycobacterial bacilli leading the bacterial cell death [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 30408-30-1. Pack Sizes: 500 μg. Product ID: HY-123635. | |
| NY-BR-1 p904 A2 acetate | T-cell clones specific for this NY-BR-1 epitope (p904) can recognize breast tumor cells expressing NY-BR-1. Molecular formula: C45H82N10O17. Mole weight: 1035.20. | |
| NY-CO-13 (139-147) | NY-CO-13(187-197) is amino acids 139 to 147 fragment of NY-CO-13. NY-CO-13 is any isoform of a protein encoded by TP53 gene. TP53 gene is the most frequently mutated gene in human cancer indicating that the TP53 gene plays a crucial role in preventing cancer formation. Synonyms: Cellular Tumor Antigen p53 (139-147); Tumor Suppressor p53 (139-147); Tp53 (139-147). | |
| NY-CO-13 (187-197) | NY-CO-13 (187-197) is amino acids 187 to 197 fragment of NY-CO-13. NY-CO-13 is any isoform of a protein encoded by TP53 gene. TP53 gene is the most frequently mutated gene in human cancer indicating that the TP53 gene plays a crucial role in preventing cancer formation. Synonyms: Cellular Tumor Antigen p53 (187-197); Tumor Suppressor p53 (187-197). | |
| Nyctanthes Arbor-Tristis Flower Extract | Use as antioxidant. Use as antibacterial agent. Group: Natural surfactants. Alternative Names: Nyctanthes arbor-tristis, ext. CAS No. 90064-34-9. Catalog: ACM90064349. | |
| NY-ESO-1 (155-163) | NY-ESO-1 (155-163) is a 9-aa peptide. NY-ESO-1 is an archetypical example of a CTA with restricted expression to germ cells and placental cells and re-expression in tumor cells. It is beneficial to research in the treatment of melanoma. Synonyms: Cancer/testis antigen 1 (155-163). | |
| NY-ESO-1 (157-165) | NY-ESO-1 (157-165) is a 9-aa peptide. NY-ESO-1 is an archetypical example of a CTA with restricted expression to germ cells and placental cells and re-expression in tumor cells. It is beneficial to research in the treatment of melanoma. Synonyms: Cancer/testis antigen 1 (157-165). | |
| NY-ESO-1 (157-165) peptide | NY-ESO-1 (157-165) peptide is a peptide fragment from NY-ESO-1 protein. NY-ESO-1 (157-165) peptide can activate the immune system, especially for HLA-A2 positive individuals, it can be recognized by CD8+ T cells, thus triggering an immune response. NY-ESO-1 (157-165) peptide is expressed in a variety of tumors and can be used as a target for tumor immunotherapy [1]. Uses: Scientific research. Group: Peptides. CAS No. 202815-17-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P10493. | |
| NY-ESO-1 (161-180) | NY-ESO-1 (161-180) is a 20-aa peptide. NY-ESO-1 is an archetypical example of a CTA with restricted expression to germ cells and placental cells and re-expression in tumor cells. It is beneficial to research in the treatment of melanoma. Synonyms: Cancer/testis antigen 1 (161-180). | |
| NY-ESO-1 peptide (1-9) | NY-ESO-1 peptide (1-9) is a 9-aa peptide. NY-ESO-1 is an archetypical example of a CTA with restricted expression to germ cells and placental cells and re-expression in tumor cells. It is beneficial to research in the treatment of melanoma. Synonyms: Cancer/testis antigen 1 (1-9). | |
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