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| Product | Description | |
|---|---|---|
| PKC-?, active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. |  |
| PKC?, active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| PKCα (C2-4) Inhibitor Peptide | PKCα (C2-4) inhibitor peptide is an inhibitor of PKC activity in HepG2 cells stimulated with calcium and pancreastatin when applied at 10 μM. Synonyms: Protein Kinase Cα (C2-4) Inhibitor Peptide. Grades: ≥95%. Molecular formula: C47H74N14O17. Mole weight: 1107.2. |  |
| PKC β pseudosubstrate | PKC β pseudosubstrate. Group: Biochemicals. Grades: Purified. CAS No. 172308-76-8. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| PKC β pseudosubstrate | PKC β pseudosubstrate, a selective cell-permeable peptide inhibitor of protein kinase C (IC50 ~ 0.5 μM), consists of amino acids 19-31 of PKC pseudosubstrate domain linked by a disulphide bridge to a cell permeabilisation Antennapedia domain vector peptide. Synonyms: PKC beta pseudosubstrate; Protein kinase C beta pseudosubstrate; H-Cys(1)-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-OH.H-Cys(1)-Arg-Phe-Ala-Arg-Lys-Gly-Ala-Leu-Arg-Gln-Lys-Asn-Val-OH; L-cysteinyl-L-arginyl-L-glutaminyl-L-isoleucyl-L-lysyl-L-isoleucyl-L-tryptophyl-L-phenylalanyl-L-glutaminyl-L-asparagyl-L-arginyl-L-arginyl-L-methionyl-L-lysyl-L-tryptophyl-L-lysyl-L-lysine (1->1')-disulfide compound with L-cysteinyl-L-arginyl-L-phenylalanyl-L-alanyl-L-arginyl-L-lysyl-glycyl-L-alanyl-L-leucyl-L-arginyl-L-glutaminyl-L-lysyl-L-asparagyl-L-valine. Grades: >98%. CAS No. 172308-76-8. Molecular formula: C177H294N62O38S3. Mole weight: 3994.84. | |
| PKCε Inhibitor Peptide | PKC? inhibitor peptide is a synthetic peptide that inhibits the translocation of PKC? to intracellular membranes, blocking activation. PKC? inhibitor peptide is commonly used in cells to evaluate the role of PKC? in various cellular responses. Synonyms: Protein Kinase C? Inhibitor Peptide; ?V1-2. Grades: ≥95%. CAS No. 182683-50-7. Molecular formula: C37H65N9O13. Mole weight: 844. | |
| PKC?II/EGFR Inhibitor - CAS 145915-60-2 | The PKC?II/EGFR Inhibitor, also referenced under CAS 145915-60-2, controls the biological activity of PKC?II/EGFR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| PKC?II Peptide Inhibitor I trifluoroacetate salt | ?95% (HPLC), lyophilized powder. Group: Fluorescence/luminescence spectroscopy. | |
| PKC-IN-1 | PKC-IN-1 has been found to be a PKCβII inhibitor that probably has biological activity in antineoplastic studies. Ki: 14.9 nM. Uses: Pkc-in-1 has been found to be a pkcβii inhibitor that probably has biological activity in antineoplastic studies. Synonyms: PKC-IN-1; SCHEMBL3325504; CS-4284; DA-48103; HY-16903; CS 4284; DA 48103; HY 16903; CS4284; DA48103; HY16903. Grades: 98%. CAS No. 1046787-18-1. Molecular formula: C25H37FN8O2. Mole weight: 500.61. | |
| PKC? Inhibitor - CAS 257879-35-9 | The PKC? Inhibitor, also referenced under CAS 257879-35-9, controls the biological activity of PKC?. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| PKC Inhibitor, EGF-R Fragment 651-658, Myristoylated | The PKC Inhibitor, EGF-R Fragment 651-658, Myristoylated controls the biological activity of PKC. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| PKC Inhibitor Peptide 19-36 | The PKC Inhibitor Peptide 19-36 controls the biological activity of PKC. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| PKC/PKD-IN-1 | PKC/PKD-IN-1 (Compound 13C) is an orally active dual protein kinase C/D ( PKC/PKD ) inhibitor with an IC 50 value of 0.6 nM for PKD1. PKC/PKD-IN-1 can attenuate high-salt diet-induced cardiac hypertrophy and can be used in the study of heart failure [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1071135-06-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-128142. |  |
| PKC?/? Pseudosubstrate Inhibitor | The PKC?/? Pseudosubstrate Inhibitor controls the biological activity of PKC?/?. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| PKC? Pseudosubstrate Inhibitor, Myristoylated | The PKC? Pseudosubstrate Inhibitor, Myristoylated controls the biological activity of PKC?. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| PKCTheta-IN-2 | PKCTheta-IN-2 (compound 14) is a potent and selective PKCθ inhibitor with an IC 50 of 0.25 nM. PKCTheta-IN-2 shows good selectivity over a wide range of kinases, including the PKC subfamily (30 kinases). PKCTheta-IN-2 inhibits the IL-2 production in a mouse ( IC 50 of 682 nM) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1810742-60-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-164756. | |
| PKC-Theta Inhibitor | PKC-theta inhibitor is a selective PKC-theta inhibitor with IC50 of 12 nM. Synonyms: CHEMBL248183; N4-((4-(Aminomethyl)Cyclohexyl)Methyl)-5-Nitro-N2-(2-(Trifluoromethoxy)Benzyl)Pyrimidine-2,4-Diamine; VC-8650; SCHEMBL3953579. Grades: 98%. CAS No. 736048-65-0. Molecular formula: C20H25F3N6O3. Mole weight: 454.4. | |
| PKCθ Pseudosubstrate Inhibitor | PKCθ pseudosubstrate inhibitor is a synthetic peptide that inhibits PKCθ activity. Synonyms: Protein Kinase Cθ Pseudosubstrate Inhibitor. Grades: ≥95%. Molecular formula: C95H165N39O20. Mole weight: 2173.6. | |
| PKC? Translocation Inhibitor Peptide | The PKC? Translocation Inhibitor Peptide, Negative Control controls the biological activity of PKC?. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| PKC? Translocation Inhibitor Peptide, Negative Control | The PKC? Translocation Inhibitor Peptide, Negative Control controls the biological activity of PKC?. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| PKCζ-IN-1 | PKCζ-IN-1 is a compound that inhibits PKCζ and CDK2, showing an IC50 value of 5.18 nM for PKCζ and 1.04 μM for CDK2, with significant selectivity of 200-fold. PKCζ-IN-1 can reduce the activity of CDK2 while inhibiting PKC&zeta. Uses: Scientific research. Group: Signaling pathways. CAS No. 1132609-87-0. Pack Sizes: 1 mg; 5 mg. Product ID: HY-120497. | |
| PKC ζ pseudosubstrate | PKC ζ pseudosubstrate, a synthetic peptide, is an inhibitor of protein kinase C (PKC) ζ that attached to cell permeabilisation Antennapedia domain vector peptide. Synonyms: Myristolated PKC Zeta, Pseudosubstrate (ZIP); Myr-Ser-Ile-Tyr-Arg-Arg-Gly-Ala-Arg-Arg-Trp-Arg-Lys-Leu-OH. Molecular formula: C208H336N74O44S3. Mole weight: 4673.59. | |
| PKC ζ pseudosubstrate | PKC ζ pseudosubstrate. Group: Biochemicals. Grades: Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| PKC ζ pseudosubstrate acetate | PKC ζ pseudosubstrate acetate, a synthetic peptide, is an inhibitor of protein kinase C (PKC) ζ that is attached to cell permeabilization Antennapedia domain vector peptide. It consists of amino acids 113-129 PKC ζ pseudosubstrate domains connected by a disulfide bridge to the cell permeabilization Antennapedia domain vector peptide. Synonyms: Protein kinase C zeta pseudosubstrate acetate; L-cysteinyl-L-seryl-L-isoleucyl-L-tyrosyl-L-arginyl-L-arginyl-glycyl-L-alanyl-L-arginyl-L-arginyl-L-tryptophyl-L-arginyl-L-lysyl-L-leucyl-L-tyrosyl-L-arginyl-L-alanyl-L-asparagine (1->1')-disulfide compound with L-cysteinyl-L-arginyl-L-glutaminyl-L-isoleucyl-L-lysyl-L-isoleucyl-L-tryptophyl-L-phenylalanyl-L-glutaminyl-L-asparagyl-L-arginyl-L-arginyl-L-methionyl-L-lysyl-L-tryptophyl-L-lysyl-L-lysine; H-Cys-Ser-Ile-Tyr-Arg-Arg-Gly-Ala-Arg-Arg-Trp-Arg-Lys-Leu-Tyr-Arg-Ala-Asn-OH.H-Cys-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-OH (Disulfide bridge: Cys1-Cys1'). Grades: ≥95%. Molecular formula: C210H340N74O46S3. Mole weight: 4733.68. | |
| PKCζ Pseudosubstrate Inhibitor | PKCζ pseudosubstrate inhibitor is a synthetic peptide that inhibits PKCζ activity. Synonyms: Protein Kinase Cζ Pseudosubstrate Inhibitor. Grades: ≥95%. CAS No. 799764-07-1. Molecular formula: C76H128N30O16. Mole weight: 1718. | |
| PKD2 Active human | recombinant, expressed in E. coli, ?70% (SDS-PAGE), aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| PKD-IN-1 dihydrochloride | PKD-IN-1 dihydrochloride (compound 32), an aminoethylamino-aryl (AEAA) compound, acts as PKD-1 inhibitor. PKD-IN-1 can be used for protein kinase D (PKD)-mediated diseases research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2308510-39-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131962A. | |
| PKD Inhibitor, CID755673 - CAS 521937-07-5 | The PKD Inhibitor, CID755673, also referenced under CAS 521937-07-5, controls the biological activity of PKD. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| PKF118-310 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PKG1alpha active human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| PKG Drug G1 | PKG drug G1 is an activator of protein kinase GIα (PKGIα). It induces vasodilation and blood pressure reduction through the C42 PKG Iα independent mechanism. Synonyms: Thiourea Deriv. 8; BDBM6641; CHEMBL141962; ZPA70378; HY-112197. Grades: 98%. CAS No. 374703-78-3. Molecular formula: C13H11N3OS. Mole weight: 257.31. | |
| PKG I? Inhibitor, Cell-Permeable | The PKG I? Inhibitor, Cell-Permeable controls the biological activity of PKG I?. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| PKG Inhibitor | The PKG Inhibitor controls the biological activity of PKG. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| PKG inhibitor peptide TFA | PKG inhibitor peptide TFA is an ATP-competitive inhibitor of cGMP-dependent protein kinase (PKG) with a Ki of 86 μM. It is an analog of a substrate peptide corresponding to a phosphorylation site of histone H2B, and inhibits phosphorylation of intact histones by PKA. Synonyms: H-Arg-Lys-Arg-Ala-Arg-Lys-Glu-OH.TFA; L-arginyl-L-lysyl-L-arginyl-L-alanyl-L-arginyl-L-lysyl-L-glutamic acid trifluoroacetic acid; cGMP Dependent Kinase Inhibitor Peptide TFA. Grades: ≥95%. Molecular formula: C40H75F3N18O12. Mole weight: 1057.13. | |
| PKG Substrate | PKG Substrate is a selective substrate for cGMP-dependent protein kinase ( PKG ). Uses: Scientific research. Group: Peptides. CAS No. 81187-14-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1561. | |
| PKG Substrate | PKG Substrate is a selective substrate for cGMP-dependent protein kinase (PKG). Synonyms: Arg-Lys-Arg-Ser-Arg-Ala-Glu; L-arginyl-L-lysyl-L-arginyl-L-seryl-L-arginyl-L-alanyl-L-glutamic acid; N5-(Diaminomethylidene)-L-ornithyl-L-lysyl-N5-(diaminomethylidene)-L-ornithyl-L-seryl-N5-(diaminomethylidene)-L-ornithyl-L-alanyl-L-glutamic acid; (S)-2-((6S,9S,12S,15S,18S,21S)-1,6-diamino-9-(4-aminobutyl)-12,18-bis(3-guanidinopropyl)-15-(hydroxymethyl)-1-imino-21-methyl-7,10,13,16,19-pentaoxo-2,8,11,14,17,20-hexaazadocosanamido)pentanedioic acid. Grades: ≥95%. CAS No. 81187-14-6. Molecular formula: C35H67N17O11. Mole weight: 902.01. | |
| PKG Substrate acetate | PKG Substrate acetate is a selective substrate for cGMP-dependent protein kinase (PKG). Synonyms: H-Arg-Lys-Arg-Ser-Arg-Ala-Glu-OH.CH3CO2H; L-arginyl-L-lysyl-L-arginyl-L-seryl-L-arginyl-L-alanyl-L-glutamic acid acetic acid. Grades: ≥95%. Molecular formula: C37H71N17O13. Mole weight: 962.08. | |
| PKI 14-22 amide, myristoylated | PKI 14-22 amide, myristoylated is a cell-permeable version of protein kinase inhibitor PKI (14-22) amide. N-terminus is myristoylated to increase cell membrane permeability. The non-myristoylated version of this peptide is a highly specific inhibitor of cAMP-dependent protein kinase (PKA) with Ki=36 nM. This product is a useful tool for studying PKA in cellular systems. Synonyms: Protein kinase inhibitor-(14-22)-amide, myristoylated. Grades: >98%. CAS No. 201422-03-9. Molecular formula: C53H100N20O12. Mole weight: 1209.5. | |
| PKI 14-22 amide, myristoylated | PKI 14-22 amide, myristoylated. Group: Biochemicals. Grades: Purified. CAS No. 201422-03-9. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| PKI-166 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PKI-166 | PKI-166 is an ATP-competitive EGFR inhibitor with >3000-fold selectivity against a panel of serine/threonine kinases. It inhibits the growth and metastasis in pancreatic cancer. It also exhibits potential therapeutic effects against several cardiovascular (CV) conditions, including hypertension, heart failure, and cardiac and vascular hypertrophy. Uses: Protein kinase inhibitors. Synonyms: PKI 166; PKI166; CGP-75166; NVP-PKI166; 4-[4-[[(1R)-1-phenylethyl]amino]-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenol. Grades: ≥98%. CAS No. 187724-61-4. Molecular formula: C20H18N4O. Mole weight: 330.4. | |
| PKI 166 hydrochloride | PKI 166 is a potent EGFR-kinase inhibitor (IC50 = 0.7 nM), with >3000-fold selectivity against a panel of serine/threonine kinases. PKI 166 potently inhibits the growth and metastasis of many human cancers including human pancreatic cancer. Synonyms: PKI 166 hydrochloride; PKI166 hydrochloride; PKI-166 hydrochloride; 4-[4-[[(1R)-1-Phenylethyl]amino]-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenol hydrochloride; PKI 166 HCl. Grades: ≥98% by HPLC. Molecular formula: C20H18N4O.HCl. Mole weight: 366.84. | |
| PKI 166 hydrochloride | PKI 166 hydrochloride. Group: Biochemicals. Grades: Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PKI-179 | PKI-179 is a second generation, small-molecule mimetic of ATP that targets the mammalian target of rapamycin (mTOR) with potential antineoplastic activity. PKI-179 selectively inhibits mTOR and phosphoinositide-3-kinase (PI3K) alpha. By inhibiting the PI3K/mTOR signaling pathway, this agent may inhibit tumor cell proliferation and survival. Synonyms: PKI-179; PKI 179; PKI179. Grades: ≥98%. CAS No. 1197160-28-3. Molecular formula: C25H28N8O3. Mole weight: 488.55. | |
| PKI-179 hydrochloride | PKI-179 is an orally bioavailable dual inhibitor of PI3K and mammalian target of rapamycin (mTOR), displaying potential antineoplastic activity. Synonyms: N-[4-[4-(4-morpholinyl)-6-(3-oxa-8-azabicyclo[3.2.1]oct-8-yl)-1,3,5-triazin-2-yl]phenyl]-N'-4-pyridinyl-urea monohydrochloride. Grades: ≥98%. CAS No. 1463510-35-1. Molecular formula: C25H28N8O3·HCl. Mole weight: 525. | |
| PKI-402 | PKI-402 is a selective, reversible, ATP-competitive, equipotent inhibitor of class I phosphatidylinositol 3-kinases (PI3K), including PI3K-alpha mutants, and mammalian target of rapamycin (mTOR; IC(50) versus PI3K-alpha = 2 nmol/L). PKI-402 inhibited growth of human tumor cell lines derived from breast, brain (glioma), pancreas, and non-small cell lung cancer tissue and suppressed phosphorylation of PI3K and mTOR effector proteins (e.g., Akt at T308) at concentrations that matched those that inhibited cell growth. Synonyms: PKI-402; PKI 402; PKI402. Grades: 0.98. CAS No. 1173204-81-3. Molecular formula: C29H34N10O3. Mole weight: 570.658. | |
| PKI (5-24) | PKI (5-24) is a competitive, non-reversible peptide inhibitor of PKA (cAMP-dependent protein kinase) (Ki = 2.3 nM). Its sequence is derived from the heat-stable skeletal muscle inhibitor protein of PKA. The PKA Inhibitor peptide binds to the catalytic subunit of PKA and displaces the regulatory subunit, and mimics protein substrate by binding to the catalytic site via the Arg-cluster basic residues. Synonyms: L-threonyl-L-threonyl-L-tyrosyl-L-alanyl-L-a-aspartyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-serylglycyl-L-arginyl-L-threonylglycyl-larginyl-L-aspartic acid; PKI (5-24); Protein Kinase A Inhibitor (5-24). CAS No. 99534-03-9. Molecular formula: C94H148N32O31. Mole weight: 2222.4. | |
| PKI (5-24) acetate | PKI (5-24) acetate is a competitive, non-reversible peptide inhibitor of PKA (cAMP-dependent protein kinase) (Ki = 2.3 nM). Synonyms: H-Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-His-Asp-OH.CH3CO2H; L-Threonyl-L-threonyl-L-tyrosyl-L-alanyl-L-α-aspartyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-serylglycyl-L-arginyl-L-threonylglycyl-L-arginyl-L-arginyl-L-asparaginyl-L-alanyl-L-isoleucyl-L-histidyl-L-aspartic acid acetate salt; PKI(5-24) acetate salt. Grades: ≥95%. Molecular formula: C96H152N32O33. Mole weight: 2282.43. | |
| PKLR Var1 active human | recombinant, expressed in E. coli, ?43% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| PKLR Var2 active human | recombinant, expressed in E. coli, ?90% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| PKM1 active human | recombinant, expressed in E. coli, ?80% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| PKM2 Activator III (N- (4- (4- (2-Methoxyphenyl) piperazine-1-carbonyl) phenyl) quinoline-8-sulfonamide, Pyruvate Kinase M2 Activator III) | A cell-permeable quinoline-sulfonamide that acts as a potent allosteric PKM2 activator both in cell-free enzymatic assays (AC50 = 17nM with 40ng PKM2/200ul) and in cultures (AC50 = 45nM in A549 cells) via a high affinity, 2:1 stoichiometric binding, effectively locking PKM2 in an active tetrameric state resistant to known intracellular negative regulators of FBP-activated PKM2 tetramer. PKM2 stimulation by compound treatment is shown to result in decreased serine biosynthesis (by 56%; 500nM for 24h) with concomitant increase in serine influx as a compensating mechanism for maintaining cellular serine level necessary for supporting A549 proliferation. Simultaneous PKM2 activation and culture serine withdrawal results in cytostatic A549 growth arrest, but not apoptosis. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PKM2-IN-1 | PKM2-IN-1 is a PKM2 inhibitor with IC50 value of 2.95 μM. Synonyms: PKM2 inhibitor; Compound 3k; (3-methyl-1,4-dioxonaphthalen-2-yl)methyl piperidine-1-carbodithioate. CAS No. 94164-88-2. Molecular formula: C18H19NO2S2. Mole weight: 345.48. | |
| PKN2/PRK2, active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| PKN3 active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| PknG Inhibitor - CAS 329221-38-7 | The PknG Inhibitor, also referenced under CAS 329221-38-7, controls the biological activity of PknG. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| PKR activator 3 | PKR activator 3 is a pyruvate kinase isoform PKR activator extracted from patent WO2014139144A1, compound 160. PKR activator 3 can be used for the research of PKR function related diseases, including cancer, diabetes, obesity, autoimmune disorders, and benign prostatic hyperplasia [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1628428-01-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-19702. | |
| PKR-IN-1 | Activator of pyruvate kinase isoenzyme M2 (PKM2), an enzyme involved in glycolysis. Since all tumor cells exclusively express the embryonic M2 isoform of PK, it is hypothesized that PKM2 is a potential target for cancer therapy. Modulation of PKM2 might also be effective in the treatment of obesity, diabetes, autoimmune conditions, and antiproliferation-dependent diseases. Synonyms: PKR-IN-1; PKM2 activator 1020; PKM2 activator; Mitapivat. Grades: >98%. CAS No. 1260075-17-9. Molecular formula: C24H26N4O3S. Mole weight: 450.55. | |
| PKR-IN-2 | PKR-IN-2 is a pyruvate kinase (PKR) activator. IC50: PKR (R510Q) <100 nM. Synonyms: N-[4-[4-hydroxy-4-(2-methylpropyl)piperidine-1-carbonyl]phenyl]quinoxaline-5-sulfonamide PKR-IN-2 SCHEMBL16049613. CAS No. 1628428-01-2. Molecular formula: C24H28N4O4S. Mole weight: 468.57. | |
| PKR Inhibitor - CAS 608512-97-6 | The PKR Inhibitor, also referenced under CAS 608512-97-6, controls the biological activity of PKR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| PKR Inhibitor III, 7DG (Double-stranded RNA-activated Protein Kinase Inhibitor III, EIF2AK2 Inhibitor III, 7-Desacetoxy-6,7-dehydrogedunin, Double-stranded RNA-dependent Protein Kinase Inhibitor III) | A cell-permeable gedunin analog that directly targets PKR via reversible interaction inhibits PKR-mediated cellular events by disrupting PKR signaling complexes assembly, such as IkK complex and inflammasome / pyroptosome, resulting in effective blockage of LPS-induced IkBbeta degradaion (20uM) and protection against anthrax toxin LT-induced caspase-1 activation as well as subsequent pyroptosis (10uM) in murine macrophage J774 cultures. PKR is also known to mediate LT-induced apoptosis via its kinase activity in LPS-primed Macrophages derived from C57BL/6 with a resistent NLRP1 allele, inhibitable by C16, but not by 7DG, while LT-induced pyroptosis in J774 cultures is insensitive to C16 treatment. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. Molecular Formula: C??H??O?. US Biological Life Sciences. | Worldwide |
| PKR Inhibitor, Negative Control - CAS 852547-30-9 | The PKR Inhibitor, Negative Control, also referenced under CAS 852547-30-9, controls the biological activity of PKR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| PKSI-527 | PKSI-527 is a new, highly selective plasma kallikrein inhibitor. PKSI-527 can suppress collagen-induced arthritis (CIA) by modifying the kallikrein-kinin system [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 128837-71-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123133. | |
| PKSI-527 | PKSI-527 is a potent and selective inhibitor of plasma kallikrein with Ki value of 0.81 μM. PKSI-527 may be a useful tool for exploring the mechanism of disseminated intravascular coagulation (DIC) and the accompanying organ failure. Synonyms: 2-[4-[[ (2S) -2-[[4- (aminomethyl) cyclohexanecarbonyl]amino]-3-phenylpropanoyl]amino]phenyl]acetic acid hydrochloride. Grades: ≥95%. CAS No. 128837-71-8. Molecular formula: C25H31N3O4·HCl. Mole weight: 474. | |
| PK-THPP | PK-THPP is a potent antagonist of tandem pore potassium channel subunit TASK-3 (KCNK9, K2P9.1) with an IC50 value of 35 nM for TASK-3 compared to 303 nM for TASK-1 and with >140 fold selectivity over a wider range of potassium channels. PK-THPP ncreases breathing rate and induces respiratory alkalosis in rats. It induced a respiratory alkalosis and increased oxygenation. Synonyms: 1-[1-[6-[[1,1'-Biphenyl]-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]-4-piperidinyl]-1-butanone; PK-THPP; PK THPP; PKTHPP. Grades: ≥99% by HPLC. CAS No. 1332454-07-5. Molecular formula: C29H32N4O2. Mole weight: 468.59. | |
| PK-THPP | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PK-THPP | PK-THPP. Group: Biochemicals. Grades: Purified. CAS No. 1332454-07-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| PKUMDL WQ 2101 | PKUMDL WQ 2101 is a negative allosteric modulator of phosphoglycerate dehydrogenase (PHGDH) (IC50 = 34.8 μM). It exhibits antitumor activity in vitro in breast cancer cell lines overexpressing PHGDH (EC50 values are 7.7 and 10.8 μM in MDA-MB-468 and HCC-70 cells, respectively). Synonyms: 2,4-Dihydroxy-N'-(2-hydroxy-5-nitrobenzylidene)benzohydrazide. Grades: ≥98% by HPLC. CAS No. 304481-72-9. Molecular formula: C14H11N3O6. Mole weight: 317.25. | |
| PKUMDL-WQ-2101 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PKUMDL WQ 2201 | PKUMDL WQ 2201 is a negative allosteric modulator of phosphoglycerate dehydrogenase (PHGDH) (IC50 = 35.7 μM). It exhibits antitumor activity. Synonyms: 2-Chloro-4-[5-[[2-[ (ethylamino) thioxomethyl]hydrazinylidene]methyl]-2-furanyl]benzoic acid. Grades: ≥98% by HPLC. CAS No. 592474-91-4. Molecular formula: C15H14ClN3O3S. Mole weight: 351.81. | |
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