American Chemical Suppliers
A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
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Product | Description | |
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PKA inhibitor fragment (6-22) amide Quick inquiry Where to buy Suppliers range | PKA inhibitor fragment (6-22) amide is the shortest synthetic PKI peptide, and acts as a potent protein kinase A (PKA) inhibitor. Uses: Peptide Inhibitors. CAS No. 121932-06-7. Product ID: R0953. | |
PKA inhibitor fragment (6-22) amide acetate Quick inquiry Where to buy Suppliers range | PKA Inhibitor Fragment (6-22) amide acetate is a synthetic peptide inhibitor of cAMP-dependent protein kinase (PKA) (Ki = 2.5 nM), derived from the heat-stable PKA inhibitor protein PKI. It is the shortest synthetic PKI peptide that retains high potency for PKA inhibition. Synonyms: H-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2.CH3CO2H; L-threonyl-L-tyrosyl-L-alanyl-L-alpha-aspartyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-seryl-glycyl-L-arginyl-L-threonyl-glycyl-L-arginyl-L-arginyl-L-asparagyl-L-alanyl-L-isoleucinamide acetic acid. Grades: ≥95%. Molecular formula: C82H134N28O26. Mole weight: 1928.11. | |
PKC (19-36) Quick inquiry Where to buy Suppliers range | PKC (19-36), corresponding to PKC pseudosubstrate regulatory sequence, is a potent and selective protein kinase C (PKC) inhibitor. Uses: Peptide Inhibitors. CAS No. 113731-96-7. Product ID: R0991. | |
PKC (19-36) Quick inquiry Where to buy Suppliers range | PKC (19-36) is a pseudosubstrate peptide inhibitor of protein kinase C (IC50 = 0.18 μM). Synonyms: Gly-Arg-Pro-Arg-Thr-Ser-Ser-Phe-Ala-Glu-Gly. Grades: >97%. CAS No. 113731-96-7. Molecular formula: C93H159N35O24. Mole weight: 2151.48. | |
PKC (19-36) Quick inquiry Where to buy Suppliers range | PKC (19-36). Group: Biochemicals. Grades: Purified. CAS No. 113731-96-7. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
PKC 20-28, Cell-Permeable, Myristoylated Quick inquiry Where to buy Suppliers range | Pseudosubstrate sequence from protein kinase Cα and β ( PKCα and PKCβ). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 500μG. Mole weight: 1255.60. Catalog: IAR42415586. Assay: ≥95% (HPLC). | |
PKC-9 Quick inquiry Where to buy Suppliers range | PKC-9 is a potent and selective inhibitor of PKCζ with IC50 value of 5.18 nM. Synonyms: 4-[3-[7-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-1H-indazol-6-yl]-benzenamine. Grades: ≥95%. CAS No. 1132609-87-0. Molecular formula: C25H25N7. Mole weight: 423.51. | |
PKC Activator VII, CGK062 (Protein Kinase C Activator VII) Quick inquiry Where to buy Suppliers range | A cell permeable coumarin-containing compound that is shown to activate PKCalpha activity and induce cellular PKCalpha membrane translocation (Effective conc. 12.5 to 50uM) as well as PKCalpha-mediated signaling events. Effectively affects the viability of CRT-dependent cancer cells (IC50 = 1.62 to 18.6uM; 48h) in vitro and suppresses PC3-derived tumor expansion in mice (50 & 100mg/kg/day; i.p) in vivo, while exhibiting little cytotoxicity toward WI38 normal fibroblasts. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2mg. Molecular Formula: C??H??O?, Primary Target IC50: 12.2uM. US Biological Life Sciences. | Worldwide |
PKCα (C2-4) Inhibitor Peptide Quick inquiry Where to buy Suppliers range | PKCα (C2-4) inhibitor peptide is an inhibitor of PKC activity in HepG2 cells stimulated with calcium and pancreastatin when applied at 10 μM. Synonyms: Protein Kinase Cα (C2-4) Inhibitor Peptide. Grades: ≥95%. Molecular formula: C47H74N14O17. Mole weight: 1107.2. | |
PKCβII Peptide Inhibitor I trifluoroacetate salt Quick inquiry Where to buy Suppliers range | ≥95% (HPLC), lyophilized powder. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 862502-26-9 (free base). Pack Sizes: 1MG. Mole weight: 1299.47 (free base basis). Catalog: ALP862502269. Assay: ≥95% (HPLC). | |
PKC β pseudosubstrate Quick inquiry Where to buy Suppliers range | PKC β pseudosubstrate. Group: Biochemicals. Grades: Purified. CAS No. 172308-76-8. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
PKC β pseudosubstrate Quick inquiry Where to buy Suppliers range | PKC β pseudosubstrate, a selective cell-permeable peptide inhibitor of protein kinase C (IC50 ~ 0.5 μM), consists of amino acids 19-31 of PKC pseudosubstrate domain linked by a disulphide bridge to a cell permeabilisation Antennapedia domain vector peptide. Synonyms: PKC beta pseudosubstrate; Protein kinase C beta pseudosubstrate; H-Cys(1)-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-OH.H-Cys(1)-Arg-Phe-Ala-Arg-Lys-Gly-Ala-Leu-Arg-Gln-Lys-Asn-Val-OH; L-cysteinyl-L-arginyl-L-glutaminyl-L-isoleucyl-L-lysyl-L-isoleucyl-L-tryptophyl-L-phenylalanyl-L-glutaminyl-L-asparagyl-L-arginyl-L-arginyl-L-methionyl-L-lysyl-L-tryptophyl-L-lysyl-L-lysine (1->1')-disulfide compound with L-cysteinyl-L-arginyl-L-phenylalanyl-L-alanyl-L-arginyl-L-lysyl-glycyl-L-alanyl-L-leucyl-L-arginyl-L-glutaminyl-L-lysyl-L-asparagyl-L-valine. Grades: >98%. CAS No. 172308-76-8. Molecular formula: C177H294N62O38S3. Mole weight: 3994.84. | |
PKC β pseudosubstrate Quick inquiry Where to buy Suppliers range | Selective cell-permeable PKC inhibitor peptide. Consists of amino acids 19 - 31 of PKC pseudosubstrate domain linked by a disulphide bridge to a cell permeabilisation Antennapedia domain vector peptide. Uses: Peptide Inhibitors. CAS No. 172308-76-8. Product ID: R0946. | |
PKCε Inhibitor Peptide Quick inquiry Where to buy Suppliers range | PKC? inhibitor peptide is a synthetic peptide that inhibits the translocation of PKC? to intracellular membranes, blocking activation. PKC? inhibitor peptide is commonly used in cells to evaluate the role of PKC? in various cellular responses. Synonyms: Protein Kinase C? Inhibitor Peptide; ?V1-2. Grades: ≥95%. CAS No. 182683-50-7. Molecular formula: C37H65N9O13. Mole weight: 844. | |
PKCε Translocation Inhibitor Peptide Quick inquiry Where to buy Suppliers range | The PKCε Translocation Inhibitor Peptide, Negative Control controls the biological activity of PKC&epsilon. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 5MG. Mole weight: 843.96. Catalog: IAR42415589. Assay: ≥97% (HPLC). | |
PKCε Translocation Inhibitor Peptide, Negative Control Quick inquiry Where to buy Suppliers range | The PKCε Translocation Inhibitor Peptide, Negative Control controls the biological activity of PKC&epsilon. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 5MG. Mole weight: 843.96. Catalog: IAR42415590. Assay: ≥96% (HPLC). | |
PKCη Pseudosubstrate Inhibitor, Myristoylated Quick inquiry Where to buy Suppliers range | The PKCη Pseudosubstrate Inhibitor, Myristoylated controls the biological activity of PKC&eta. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 500μG. Mole weight: 2373.88. Catalog: IAR42415592. Assay: ≥95% (HPLC). | |
PKC-IN-1 Quick inquiry Where to buy Suppliers range | PKC-IN-1 has been found to be a PKCβII inhibitor that probably has biological activity in antineoplastic studies. Ki: 14.9 nM. Uses: Pkc-in-1 has been found to be a pkcβii inhibitor that probably has biological activity in antineoplastic studies. Synonyms: PKC-IN-1; SCHEMBL3325504; CS-4284; DA-48103; HY-16903; CS 4284; DA 48103; HY 16903; CS4284; DA48103; HY16903. Grades: 98%. CAS No. 1046787-18-1. Molecular formula: C25H37FN8O2. Mole weight: 500.61. | |
PKC Inhibitor, EGF-R Fragment 651-658, Myristoylated Quick inquiry Where to buy Suppliers range | The PKC Inhibitor, EGF-R Fragment 651-658, Myristoylated controls the biological activity of PKC. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 500μG. Mole weight: 1308.71. Catalog: IAR42415585. Assay: ≥97% (HPLC). | |
PKC Inhibitor Peptide 19-36 Quick inquiry Where to buy Suppliers range | The PKC Inhibitor Peptide 19-36 controls the biological activity of PKC. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 500μG. Mole weight: 2151.48. Catalog: IAR42415591. Assay: ≥95% (HPLC). | |
PKCθ/δ Inhibitor Quick inquiry Where to buy Suppliers range | PKCθ/δ Inhibitor. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 5MG. Mole weight: 370.40. Catalog: IAR42415595. Assay: ≥95% (HPLC). | |
PKC-Theta Inhibitor Quick inquiry Where to buy Suppliers range | PKC-theta inhibitor is a selective PKC-theta inhibitor with IC50 of 12 nM. Synonyms: CHEMBL248183; N4-((4-(Aminomethyl)Cyclohexyl)Methyl)-5-Nitro-N2-(2-(Trifluoromethoxy)Benzyl)Pyrimidine-2,4-Diamine; VC-8650; SCHEMBL3953579. Grades: 98%. CAS No. 736048-65-0. Molecular formula: C20H25F3N6O3. Mole weight: 454.4. | |
PKCθ Pseudosubstrate Inhibitor Quick inquiry Where to buy Suppliers range | PKCθ pseudosubstrate inhibitor is a synthetic peptide that inhibits PKCθ activity. Synonyms: Protein Kinase Cθ Pseudosubstrate Inhibitor. Grades: ≥95%. Molecular formula: C95H165N39O20. Mole weight: 2173.6. | |
PKCθ Pseudosubstrate Inhibitor, Myristoylated Quick inquiry Where to buy Suppliers range | The PKCθ Pseudosubstrate Inhibitor, Myristoylated controls the biological activity of PKC&theta. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 500μG. Mole weight: 2318.85. Catalog: IAR42415594. Assay: ≥95% (HPLC). | |
PKCζ/Ι Pseudosubstrate Inhibitor Quick inquiry Where to buy Suppliers range | The PKCζ/Ι Pseudosubstrate Inhibitor controls the biological activity of PKCζ/&Iota. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 500μG. Mole weight: 1718.02. Catalog: IAR42415593. Assay: ≥95% (HPLC). | |
PKC ζ pseudosubstrate Quick inquiry Where to buy Suppliers range | PKC ζ pseudosubstrate, a synthetic peptide, is an inhibitor of protein kinase C (PKC) ζ that attached to cell permeabilisation Antennapedia domain vector peptide. Synonyms: Myristolated PKC Zeta, Pseudosubstrate (ZIP); Myr-Ser-Ile-Tyr-Arg-Arg-Gly-Ala-Arg-Arg-Trp-Arg-Lys-Leu-OH. Molecular formula: C208H336N74O44S3. Mole weight: 4673.59. | |
PKC ζ pseudosubstrate Quick inquiry Where to buy Suppliers range | PKC ζ pseudosubstrate. Group: Biochemicals. Grades: Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
PKC ζ pseudosubstrate acetate Quick inquiry Where to buy Suppliers range | PKC ζ pseudosubstrate acetate, a synthetic peptide, is an inhibitor of protein kinase C (PKC) ζ that is attached to cell permeabilization Antennapedia domain vector peptide. It consists of amino acids 113-129 PKC ζ pseudosubstrate domains connected by a disulfide bridge to the cell permeabilization Antennapedia domain vector peptide. Synonyms: Protein kinase C zeta pseudosubstrate acetate; L-cysteinyl-L-seryl-L-isoleucyl-L-tyrosyl-L-arginyl-L-arginyl-glycyl-L-alanyl-L-arginyl-L-arginyl-L-tryptophyl-L-arginyl-L-lysyl-L-leucyl-L-tyrosyl-L-arginyl-L-alanyl-L-asparagine (1->1')-disulfide compound with L-cysteinyl-L-arginyl-L-glutaminyl-L-isoleucyl-L-lysyl-L-isoleucyl-L-tryptophyl-L-phenylalanyl-L-glutaminyl-L-asparagyl-L-arginyl-L-arginyl-L-methionyl-L-lysyl-L-tryptophyl-L-lysyl-L-lysine; H-Cys-Ser-Ile-Tyr-Arg-Arg-Gly-Ala-Arg-Arg-Trp-Arg-Lys-Leu-Tyr-Arg-Ala-Asn-OH.H-Cys-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-OH (Disulfide bridge: Cys1-Cys1'). Grades: ≥95%. Molecular formula: C210H340N74O46S3. Mole weight: 4733.68. | |
PKCζ Pseudosubstrate Inhibitor Quick inquiry Where to buy Suppliers range | PKCζ pseudosubstrate inhibitor is a synthetic peptide that inhibits PKCζ activity. Synonyms: Protein Kinase Cζ Pseudosubstrate Inhibitor. Grades: ≥95%. CAS No. 799764-07-1. Molecular formula: C76H128N30O16. Mole weight: 1718. | |
PKG Drug G1 Quick inquiry Where to buy Suppliers range | PKG drug G1 is an activator of protein kinase GIα (PKGIα). It induces vasodilation and blood pressure reduction through the C42 PKG Iα independent mechanism. Synonyms: Thiourea Deriv. 8; BDBM6641; CHEMBL141962; ZPA70378; HY-112197. Grades: 98%. CAS No. 374703-78-3. Molecular formula: C13H11N3OS. Mole weight: 257.31. | |
PKG Iα Inhibitor, Cell-Permeable Quick inquiry Where to buy Suppliers range | The PKG Iα Inhibitor, Cell-Permeable controls the biological activity of PKG I&alpha. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 1MG. Mole weight: 3294.07. Catalog: IAR42415610. Assay: ≥95% (HPLC). | |
PKG Inhibitor Quick inquiry Where to buy Suppliers range | The PKG Inhibitor controls the biological activity of PKG. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 1MG. Mole weight: 943.11. Catalog: IAR42415609. Assay: ≥95% (HPLC). | |
PKG inhibitor peptide TFA Quick inquiry Where to buy Suppliers range | PKG inhibitor peptide TFA is an ATP-competitive inhibitor of cGMP-dependent protein kinase (PKG) with a Ki of 86 μM. It is an analog of a substrate peptide corresponding to a phosphorylation site of histone H2B, and inhibits phosphorylation of intact histones by PKA. Synonyms: H-Arg-Lys-Arg-Ala-Arg-Lys-Glu-OH.TFA; L-arginyl-L-lysyl-L-arginyl-L-alanyl-L-arginyl-L-lysyl-L-glutamic acid trifluoroacetic acid; cGMP Dependent Kinase Inhibitor Peptide TFA. Grades: ≥95%. Molecular formula: C40H75F3N18O12. Mole weight: 1057.13. | |
PKG Substrate Quick inquiry Where to buy Suppliers range | PKG Substrate is a selective substrate for cGMP-dependent protein kinase (PKG). Uses: Peptide Inhibitors. Product ID: R1620. | |
PKG Substrate Quick inquiry Where to buy Suppliers range | PKG Substrate is a selective substrate for cGMP-dependent protein kinase (PKG). Synonyms: Arg-Lys-Arg-Ser-Arg-Ala-Glu; L-arginyl-L-lysyl-L-arginyl-L-seryl-L-arginyl-L-alanyl-L-glutamic acid; N5-(Diaminomethylidene)-L-ornithyl-L-lysyl-N5-(diaminomethylidene)-L-ornithyl-L-seryl-N5-(diaminomethylidene)-L-ornithyl-L-alanyl-L-glutamic acid; (S)-2-((6S,9S,12S,15S,18S,21S)-1,6-diamino-9-(4-aminobutyl)-12,18-bis(3-guanidinopropyl)-15-(hydroxymethyl)-1-imino-21-methyl-7,10,13,16,19-pentaoxo-2,8,11,14,17,20-hexaazadocosanamido)pentanedioic acid. Grades: ≥95%. CAS No. 81187-14-6. Molecular formula: C35H67N17O11. Mole weight: 902.01. | |
PKG Substrate acetate Quick inquiry Where to buy Suppliers range | PKG Substrate acetate is a selective substrate for cGMP-dependent protein kinase (PKG). Synonyms: H-Arg-Lys-Arg-Ser-Arg-Ala-Glu-OH.CH3CO2H; L-arginyl-L-lysyl-L-arginyl-L-seryl-L-arginyl-L-alanyl-L-glutamic acid acetic acid. Grades: ≥95%. Molecular formula: C37H71N17O13. Mole weight: 962.08. | |
PKI 14-22 amide, myristoylated Quick inquiry Where to buy Suppliers range | PKI (14-22) amide (myristoylated) is cell-permeable protein kinase A inhibitor. The non-myristoylated type of this peptide is a highly specific inhibitor of cAMP-dependent protein kinase (PKA), N-terminus is myristoylated to increase cell membrane permeability. It is usually used to study PKA in cellular systems in-vitro. Uses: Peptide Inhibitors. CAS No. 201422-03-9. Product ID: R0879. | |
PKI 14-22 amide, myristoylated Quick inquiry Where to buy Suppliers range | PKI 14-22 amide, myristoylated is a cell-permeable version of protein kinase inhibitor PKI (14-22) amide. N-terminus is myristoylated to increase cell membrane permeability. The non-myristoylated version of this peptide is a highly specific inhibitor of cAMP-dependent protein kinase (PKA) with Ki=36 nM. This product is a useful tool for studying PKA in cellular systems. Synonyms: Protein kinase inhibitor-(14-22)-amide, myristoylated. Grades: >98%. CAS No. 201422-03-9. Molecular formula: C53H100N20O12. Mole weight: 1209.5. | |
PKI 14-22 amide, myristoylated Quick inquiry Where to buy Suppliers range | PKI 14-22 amide, myristoylated. Group: Biochemicals. Grades: Purified. CAS No. 201422-03-9. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
PKI-166 Quick inquiry Where to buy Suppliers range | PKI-166 is an ATP-competitive EGFR inhibitor with >3000-fold selectivity against a panel of serine/threonine kinases. It inhibits the growth and metastasis in pancreatic cancer. It also exhibits potential therapeutic effects against several cardiovascular (CV) conditions, including hypertension, heart failure, and cardiac and vascular hypertrophy. Uses: Protein kinase inhibitors. Synonyms: PKI 166; PKI166; CGP-75166; NVP-PKI166; 4-[4-[[(1R)-1-phenylethyl]amino]-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenol. Grades: ≥98%. CAS No. 187724-61-4. Molecular formula: C20H18N4O. Mole weight: 330.4. | |
PKI 166 hydrochloride Quick inquiry Where to buy Suppliers range | PKI 166 hydrochloride. Group: Biochemicals. Grades: Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
PKI 166 hydrochloride Quick inquiry Where to buy Suppliers range | PKI 166 is a potent EGFR-kinase inhibitor (IC50 = 0.7 nM), with >3000-fold selectivity against a panel of serine/threonine kinases. PKI 166 potently inhibits the growth and metastasis of many human cancers including human pancreatic cancer. Synonyms: PKI 166 hydrochloride; PKI166 hydrochloride; PKI-166 hydrochloride; 4-[4-[[(1R)-1-Phenylethyl]amino]-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenol hydrochloride; PKI 166 HCl. Grades: ≥98% by HPLC. Molecular formula: C20H18N4O.HCl. Mole weight: 366.84. | |
PKI-179 Quick inquiry Where to buy Suppliers range | PKI-179 is a second generation, small-molecule mimetic of ATP that targets the mammalian target of rapamycin (mTOR) with potential antineoplastic activity. PKI-179 selectively inhibits mTOR and phosphoinositide-3-kinase (PI3K) alpha. By inhibiting the PI3K/mTOR signaling pathway, this agent may inhibit tumor cell proliferation and survival. Synonyms: PKI-179; PKI 179; PKI179. Grades: ≥98%. CAS No. 1197160-28-3. Molecular formula: C25H28N8O3. Mole weight: 488.55. | |
PKI-179 hydrochloride Quick inquiry Where to buy Suppliers range | PKI-179 is an orally bioavailable dual inhibitor of PI3K and mammalian target of rapamycin (mTOR), displaying potential antineoplastic activity. Synonyms: N-[4-[4-(4-morpholinyl)-6-(3-oxa-8-azabicyclo[3.2.1]oct-8-yl)-1,3,5-triazin-2-yl]phenyl]-N'-4-pyridinyl-urea monohydrochloride. Grades: ≥98%. CAS No. 1463510-35-1. Molecular formula: C25H28N8O3·HCl. Mole weight: 525. | |
PKI-402 Quick inquiry Where to buy Suppliers range | PKI-402 is a selective, reversible, ATP-competitive, equipotent inhibitor of class I phosphatidylinositol 3-kinases (PI3K), including PI3K-alpha mutants, and mammalian target of rapamycin (mTOR; IC(50) versus PI3K-alpha = 2 nmol/L). PKI-402 inhibited growth of human tumor cell lines derived from breast, brain (glioma), pancreas, and non-small cell lung cancer tissue and suppressed phosphorylation of PI3K and mTOR effector proteins (e.g., Akt at T308) at concentrations that matched those that inhibited cell growth. Synonyms: PKI-402; PKI 402; PKI402. Grades: 0.98. CAS No. 1173204-81-3. Molecular formula: C29H34N10O3. Mole weight: 570.658. | |
PKI (5-24) Quick inquiry Where to buy Suppliers range | PKI (5-24) is a competitive, non-reversible peptide inhibitor of PKA (cAMP-dependent protein kinase) (Ki = 2.3 nM). Its sequence is derived from the heat-stable skeletal muscle inhibitor protein of PKA. The PKA Inhibitor peptide binds to the catalytic subunit of PKA and displaces the regulatory subunit, and mimics protein substrate by binding to the catalytic site via the Arg-cluster basic residues. Synonyms: L-threonyl-L-threonyl-L-tyrosyl-L-alanyl-L-a-aspartyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-serylglycyl-L-arginyl-L-threonylglycyl-larginyl-L-aspartic acid; PKI (5-24); Protein Kinase A Inhibitor (5-24). CAS No. 99534-03-9. Molecular formula: C94H148N32O31. Mole weight: 2222.4. | |
PKI (5-24) acetate Quick inquiry Where to buy Suppliers range | PKI (5-24) acetate is a competitive, non-reversible peptide inhibitor of PKA (cAMP-dependent protein kinase) (Ki = 2.3 nM). Synonyms: H-Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-His-Asp-OH.CH3CO2H; L-Threonyl-L-threonyl-L-tyrosyl-L-alanyl-L-α-aspartyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-serylglycyl-L-arginyl-L-threonylglycyl-L-arginyl-L-arginyl-L-asparaginyl-L-alanyl-L-isoleucyl-L-histidyl-L-aspartic acid acetate salt; PKI(5-24) acetate salt. Grades: ≥95%. Molecular formula: C96H152N32O33. Mole weight: 2282.43. | |
PKM2 Activator III (N- (4- (4- (2-Methoxyphenyl) piperazine-1-carbonyl) phenyl) quinoline-8-sulfonamide, Pyruvate Kinase M2 Activator III) Quick inquiry Where to buy Suppliers range | A cell-permeable quinoline-sulfonamide that acts as a potent allosteric PKM2 activator both in cell-free enzymatic assays (AC50 = 17nM with 40ng PKM2/200ul) and in cultures (AC50 = 45nM in A549 cells) via a high affinity, 2:1 stoichiometric binding, effectively locking PKM2 in an active tetrameric state resistant to known intracellular negative regulators of FBP-activated PKM2 tetramer. PKM2 stimulation by compound treatment is shown to result in decreased serine biosynthesis (by 56%; 500nM for 24h) with concomitant increase in serine influx as a compensating mechanism for maintaining cellular serine level necessary for supporting A549 proliferation. Simultaneous PKM2 activation and culture serine withdrawal results in cytostatic A549 growth arrest, but not apoptosis. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
PKM2-IN-1 Quick inquiry Where to buy Suppliers range | PKM2-IN-1 is a PKM2 inhibitor with IC50 value of 2.95 μM. Synonyms: PKM2 inhibitor; Compound 3k; (3-methyl-1,4-dioxonaphthalen-2-yl)methyl piperidine-1-carbodithioate. CAS No. 94164-88-2. Molecular formula: C18H19NO2S2. Mole weight: 345.48. | |
PKR-IN-1 Quick inquiry Where to buy Suppliers range | Activator of pyruvate kinase isoenzyme M2 (PKM2), an enzyme involved in glycolysis. Since all tumor cells exclusively express the embryonic M2 isoform of PK, it is hypothesized that PKM2 is a potential target for cancer therapy. Modulation of PKM2 might also be effective in the treatment of obesity, diabetes, autoimmune conditions, and antiproliferation-dependent diseases. Synonyms: PKR-IN-1; PKM2 activator 1020; PKM2 activator; Mitapivat. Grades: >98%. CAS No. 1260075-17-9. Molecular formula: C24H26N4O3S. Mole weight: 450.55. | |
PKR-IN-2 Quick inquiry Where to buy Suppliers range | PKR-IN-2 is a pyruvate kinase (PKR) activator. IC50: PKR (R510Q) <100 nM. Synonyms: N-[4-[4-hydroxy-4-(2-methylpropyl)piperidine-1-carbonyl]phenyl]quinoxaline-5-sulfonamide PKR-IN-2 SCHEMBL16049613. CAS No. 1628428-01-2. Molecular formula: C24H28N4O4S. Mole weight: 468.57. | |
PKR Inhibitor - CAS 608512-97-6 Quick inquiry Where to buy Suppliers range | The PKR Inhibitor, also referenced under CAS 608512-97-6, controls the biological activity of PKR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 608512-97-6. Pack Sizes: 5MG. Mole weight: 268.29. Catalog: AP608512976-C. Assay: ≥90% (HPLC). | |
PKR Inhibitor III, 7DG (Double-stranded RNA-activated Protein Kinase Inhibitor III, EIF2AK2 Inhibitor III, 7-Desacetoxy-6,7-dehydrogedunin, Double-stranded RNA-dependent Protein Kinase Inhibitor III) Quick inquiry Where to buy Suppliers range | A cell-permeable gedunin analog that directly targets PKR via reversible interaction inhibits PKR-mediated cellular events by disrupting PKR signaling complexes assembly, such as IkK complex and inflammasome / pyroptosome, resulting in effective blockage of LPS-induced IkBbeta degradaion (20uM) and protection against anthrax toxin LT-induced caspase-1 activation as well as subsequent pyroptosis (10uM) in murine macrophage J774 cultures. PKR is also known to mediate LT-induced apoptosis via its kinase activity in LPS-primed Macrophages derived from C57BL/6 with a resistent NLRP1 allele, inhibitable by C16, but not by 7DG, while LT-induced pyroptosis in J774 cultures is insensitive to C16 treatment. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. Molecular Formula: C??H??O?. US Biological Life Sciences. | Worldwide |
PKSI-527 Quick inquiry Where to buy Suppliers range | PKSI-527 is a potent and selective inhibitor of plasma kallikrein with Ki value of 0.81 μM. PKSI-527 may be a useful tool for exploring the mechanism of disseminated intravascular coagulation (DIC) and the accompanying organ failure. Synonyms: 2-[4-[[ (2S) -2-[[4- (aminomethyl) cyclohexanecarbonyl]amino]-3-phenylpropanoyl]amino]phenyl]acetic acid hydrochloride. Grades: ≥95%. CAS No. 128837-71-8. Molecular formula: C25H31N3O4·HCl. Mole weight: 474. | |
PK-THPP Quick inquiry Where to buy Suppliers range | PK-THPP is a potent antagonist of tandem pore potassium channel subunit TASK-3 (KCNK9, K2P9.1) with an IC50 value of 35 nM for TASK-3 compared to 303 nM for TASK-1 and with >140 fold selectivity over a wider range of potassium channels. PK-THPP ncreases breathing rate and induces respiratory alkalosis in rats. It induced a respiratory alkalosis and increased oxygenation. Synonyms: 1-[1-[6-[[1,1'-Biphenyl]-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]-4-piperidinyl]-1-butanone; PK-THPP; PK THPP; PKTHPP. Grades: ≥99% by HPLC. CAS No. 1332454-07-5. Molecular formula: C29H32N4O2. Mole weight: 468.59. | |
PK-THPP Quick inquiry Where to buy Suppliers range | PK-THPP. Group: Biochemicals. Grades: Purified. CAS No. 1332454-07-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
PKUMDL WQ 2101 Quick inquiry Where to buy Suppliers range | PKUMDL WQ 2101 is a negative allosteric modulator of phosphoglycerate dehydrogenase (PHGDH) (IC50 = 34.8 μM). It exhibits antitumor activity in vitro in breast cancer cell lines overexpressing PHGDH (EC50 values are 7.7 and 10.8 μM in MDA-MB-468 and HCC-70 cells, respectively). Synonyms: 2,4-Dihydroxy-N'-(2-hydroxy-5-nitrobenzylidene)benzohydrazide. Grades: ≥98% by HPLC. CAS No. 304481-72-9. Molecular formula: C14H11N3O6. Mole weight: 317.25. | |
PKUMDL WQ 2201 Quick inquiry Where to buy Suppliers range | PKUMDL WQ 2201 is a negative allosteric modulator of phosphoglycerate dehydrogenase (PHGDH) (IC50 = 35.7 μM). It exhibits antitumor activity. Synonyms: 2-Chloro-4-[5-[[2-[ (ethylamino) thioxomethyl]hydrazinylidene]methyl]-2-furanyl]benzoic acid. Grades: ≥98% by HPLC. CAS No. 592474-91-4. Molecular formula: C15H14ClN3O3S. Mole weight: 351.81. | |
PKUMDL-WQ-2201 Quick inquiry Where to buy Suppliers range | ≥98% (HPLC). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 592474-91-4. Pack Sizes: 5MG, 25MG. Mole weight: 351.81. Catalog: AP592474914. Assay: ≥98% (HPLC). | |
PL 017 Quick inquiry Where to buy Suppliers range | PL 017, a morphiceptin analog, is a selective μ opioid receptor agonist (IC50= 5.5 and > 10000 nM for inhibition of 125I-FK 33,824 and 125I-DADLE binding to μ and δ sites respectively). Although the affinity of PL017 for μ-sites is lower than that of morphine, PL 017 is more potent than morphine in all in vitro studies, suggesting a difference in the way in which peptide and alkaloid activate μ-receptors. Synonyms: Tyr-Pro-MePhe-D-Pro; PL 017; PL017; PL-017. CAS No. 83397-56-2. Molecular formula: C29H37N5O5. Mole weight: 535.64. | |
PL 017 Quick inquiry Where to buy Suppliers range | PL 017. Group: Biochemicals. Grades: Purified. CAS No. 83397-56-2. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
PL-101 Quick inquiry Where to buy Suppliers range | PL-101 is an antibacterial peptide isolated from Styela plicata. Grades: >96%. | |
PL-101 Quick inquiry Where to buy Suppliers range | PL-101. Uses: Antimicrobial Peptides. Product ID: AF025. | |
PLA 3D printing filament Quick inquiry Where to buy Suppliers range | PLA 3D printing filament. Group: 3D Printing Materials. CAS No. 9051-89-2. | |
PLA(5K)-PEG-SC,5K Quick inquiry Where to buy Suppliers range | PLA(5K)-PEG-SC,5K. Group: PEG Derivatives. Alternative Names: PLA(5K)-PEG-NHS;Polylactic acid(5K)-PEG-Succinimidyl ester. CAS No. Product ID: HE064023-5K. | |
PLA-b-PPEEA Quick inquiry Where to buy Suppliers range | Polylactic acid (PLA) is a kind of non-toxic,non irritating synthetic polymer material with excellent biodegradability,compatibility and absorbability.It can be used as drug transport material and tissue engineering scaffold material. Group: Raw Materials. Alternative Names: polylactic acid-b-PPEEA. Product ID: MSMN-062. | |
Plactin A Quick inquiry Where to buy Suppliers range | Plactin A is a cyclic pentapeptide physiologically active substance produced by the fungus F165. It can promote the dissolution of fibrinolytic protein. Molecular formula: C32H52N8O6. Mole weight: 644.80. | |
Plactin B Quick inquiry Where to buy Suppliers range | Plactin B is a cyclic pentapeptide physiologically active substance produced by the fungus F165. It can promote the dissolution of fibrinolytic protein. Synonyms: Plastin B. Molecular formula: C32H52N8O6. Mole weight: 644.80. | |
Plactin C Quick inquiry Where to buy Suppliers range | Plactin C is a cyclic pentapeptide physiologically active substance produced by the fungus F165. It can promote the dissolution of fibrinolytic protein. Synonyms: cyclo(-D-Val-L-Leu-D-alloIle-L-Phe-D-Arg-). Molecular formula: C32H52N8O5. Mole weight: 628.80. | |
Plactin D Quick inquiry Where to buy Suppliers range | Plactin D is a cyclic pentapeptide physiologically active substance produced by the fungus F165. It can promote the dissolution of fibrinolytic protein. Synonyms: Plastin D; cyclo(-D-Val-L-Leu-D-Leu-L-Phe-D-Arg-). Molecular formula: C32H52N8O5. Mole weight: 628.80. |