A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Block copolymer micelles are core-shell polymer micelles spontaneously formed by amphiphilic block copolymers dissolved in water to solubilize and encapsulate drugs. Most of the carriers are synthetic,biodegradable and thermodynamically stable in aqueous media. Synonyms: poly(L-lactide-co-glycolide)-dialcohol. Product ID: MSMN-059. Category: Raw Materials.
PLGA-fluorescein
Fluorescein labeled poly(L-lactide-co-glycolide) (PLGA-FITC, PLGA-Fluorescein) can be used to prepare fluorescent nanoparticles. Synonyms: Poly(lactide-co-glycolide)-fluorescein. Product ID: MSMN-073. Category: Raw Materials.
PLGA microsphere excipient
PLGA microspheres are a biodegradable polymer with excellent biocompatibility, non-toxicity, and ability to form membranes and capsules. CAS No. 26780-50-7. Product ID: PE-0678. Product Keywords: Excipients; PE-0678; PLGA microsphere excipient; 26780-50-7. Grade: Pharmaceutical grade. Source and Preparation: PLGA microspheres are a biodegradable polymer with excellent biocompatibility, non-toxicity, and ability to form membranes and capsules. They are widely used in drug delivery systems, drug-release systems, and tissue engineering scaffolds for medical devices, as well as biodegradable surgical sutures, anti-adhesion membranes, and tissue engineering scaffolds.
PLGA microspheres
PLGA microspheres. Group: Biodegradable polymers.
PLGA Microspheres-10 μm
Particles made of poly(D,L-lactide-co-glycolide) L/G ratio of 50/50, inherent viscosity of ~0.45 dL/gTo re-constitute: Warm to ambient temperature; Add DI water or buffer to achieve desired concentration; Vortex and sonicate for 5 minutes to ensure particles are well suspended. Synonyms: PLGA Nanoparticles. Product ID: MSMN-004. Category: Polymer Microspheres.
PLGA Microspheres-1 μm
Particles made of poly(D,L-lactide-co-glycolide) L/G ratio of 50/50, inherent viscosity of ~0.45 dL/gTo re-constitute: Warm to ambient temperature; Add DI water or buffer to achieve desired concentration; Vortex and sonicate for 5 minutes to ensure particles are well suspended. Synonyms: PLGA Nanoparticles. Product ID: MSMN-001. Category: Polymer Microspheres.
PLGA Microspheres-20 μm
Particles made of poly(D,L-lactide-co-glycolide) L/G ratio of 50/50, inherent viscosity of ~0.45 dL/gTo re-constitute: Warm to ambient temperature; Add DI water or buffer to achieve desired concentration; Vortex and sonicate for 5 minutes to ensure particles are well suspended. Synonyms: PLGA Nanoparticles. Product ID: MSMN-005. Category: Polymer Microspheres.
To re-constitute: Remove the product from freezer.Wait until temperature rises to the ambient temperature.Add DI water or buffer to the container. Vortex and sonicate for 5 minutes to ensure the microspheres are well suspended. Synonyms: PLGA Nanoparticles. Product ID: MSMN-002. Category: Polymer Microspheres.
PLGA Microspheres-30 μm
Particles made of poly(D,L-lactide-co-glycolide) L/G ratio of 50/50, inherent viscosity of ~0.45 dL/gTo re-constitute: Warm to ambient temperature; Add DI water or buffer to achieve desired concentration; Vortex and sonicate for 5 minutes to ensure particles are well suspended. Synonyms: PLGA Nanoparticles. Product ID: MSMN-007. Category: Polymer Microspheres.
PLGA Microspheres-40 μm
Particles made of poly(D,L-lactide-co-glycolide) L/G ratio of 50/50, inherent viscosity of ~0.45 dL/gTo re-constitute: Warm to ambient temperature; Add DI water or buffer to achieve desired concentration; Vortex and sonicate for 5 minutes to ensure particles are well suspended. Synonyms: PLGA Nanoparticles. Product ID: MSMN-008. Category: Polymer Microspheres.
Particles made of poly(D,L-lactide-co-glycolide) L/G ratio of 50/50, inherent viscosity of ~0.45 dL/gTo re-constitute: Warm to ambient temperature; Add DI water or buffer to achieve desired concentration; Vortex and sonicate for 5 minutes to ensure particles are well suspended. Synonyms: PLGA Nanoparticles. Product ID: MSMN-003. Category: Polymer Microspheres.
PLGA nanoparticles
100 nm average diameter. Group: Biodegradable polymers.
PLGA nanoparticles
500 nm average diameter. Group: Biodegradable polymers.
PLGA-PEG-COOH, Poly(L-lactide-co-glycolide)-Polyethyleneglycol-carboxyl is a biodegradable functional amphiphilic block copolymer for drug delivery. PLGA-PEG-COOH can conjugate with peptides, antibodies, proteinsand others which contain amine groups on the surface. Synonyms: Poly(L-lactide-co-glycolide)-Polyethylene glycol-carboxyl. Product ID: MSMN-051. Category: Raw Materials.
PLGA-PEG-NH2
PLGA-PEG-NH2, Poly(L-lactide-co-glycolide)-Polyethyleneglycol-amine is one of the most commonly used biodegradable ABC polymers for drug delivery. Synonyms: Poly(L-lactide-co-glycolide)-Polyethylene glycol-amine. Product ID: MSMN-052. Category: Raw Materials.
PLGA-PEG-PLGA (Mn (1000-1000-1000))
PLGA-PEG-PLGA is an amphiphilic triblock copolymer which can self-assemble into micelles in aqueous medium due to the hydrophobic interactions present in the hydrophobic segments. The PEG segment imparts hydrophilicity and improves the biocompatibility of the copolymer. The PLGA segment forms a hydrophobic core and can solubilize hydrophobic drugs. These copolymers are widely used as nanocarriers for the sustained release of drugs. Synonyms: Poly(lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly(lactide-co-glycolide). Product ID: MSMN-069. Category: Raw Materials.
PLGA-PEG-PLGA (Mn (1100-1000-1100))
PLGA-PEG-PLGA is an amphiphilic triblock copolymer which can self-assemble into micelles in aqueous medium due to the hydrophobic interactions present in the hydrophobic segments. The PEG segment imparts hydrophilicity and improves the biocompatibility of the copolymer. The PLGA segment forms a hydrophobic core and can solubilize hydrophobic drugs. These copolymers are widely used as nanocarriers for the sustained release of drugs. Synonyms: Poly(lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly(lactide-co-glycolide). Product ID: MSMN-068. Category: Raw Materials.
recombinant, expressed in E. coli, ?95% (SDS-PAGE), ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy.
PLGF-2 human
recombinant, expressed in E. coli, ?90% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy.
PLGF-3 human
recombinant, expressed in E. coli, ?95% (SDS-PAGE), ?95% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
PLGF from mouse
recombinant, expressed in E. coli, ?95% (SDS-PAGE), ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy.
PLGF-I human
Animal-component free, recombinant, expressed in E. coli, ?95% (SDS-PAGE), ?95% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
Plicamycin
Plicamycin (Mithramycin A) is a selective specificity protein 1 ( Sp1 ) inhibitor. Plicamycin inhibits the growth of various cancers by decreasing Sp1 protein. Plicamycin inhibits GSTM2 promoter activity and protein expression [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Mithramycin A. CAS No. 18378-89-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0122.
Plicatol B
Plicatol B is a phenanthrene isolated from the stems of the orchid Flickingeria fimbriata. Synonyms: Moscatin; 4-methoxyphenanthrene-2,5-diol. Grades: >98%. CAS No. 108335-06-4. Molecular formula: C15H12O3. Mole weight: 240.258.
Plicatol B
Plicatol B. Group: Biochemicals. CAS No. 108335-06-4. Pack Sizes: 5mg. US Biological Life Sciences.
Plinabulin (NPI-2358) is a vascular disrupting agen ( VDA ) against tubulin-depolymerizing with an IC 50 of 9.8 nM against HT-29 cells [1]. Plinabulin binds the colchicine binding site of β-tubulin preventing polymerization and has potent inhibitory to tumor cells [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NPI-2358. CAS No. 714272-27-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14444.
Plinabulin
Plinabulin is a vascular disrupting agent (VDA) against tubulin-depolymerizing with IC50 value of 9.8~18 nM in tumor cells under the development of Nereus Pharmaceuticals. It can bind to the colchicine binding site of b-tubulin preventing polymerization and disrupting the cytoplasmic microtubule network. In Sep 2016, BeyondSpring Pharmaceuticals planed a phase II/III trial for Neutropenia. Phase I clinical trials for Solid tumours and Phase III clinical trials for Non-small cell lung cancer are on-going. Uses: Non-small cell lung cancer; neutropenia;solid tumours. Synonyms: NPI 2358; NPI2358; NPI-2358; Plinabulin; UNII-986FY7F8XR; (3Z,6Z)-3-benzylidene-6-[(5-tert-butyl-1H-imidazol-4-yl)methylidene]piperazine-2,5-dione. Grades: 98%. CAS No. 714272-27-2. Molecular formula: C19H20N4O2. Mole weight: 339.39.
Plitidepsin
Plitidepsin (Aplidine) is a potent anti-cancer agent by targeting eEF1A2 ( K D =80?nM) [1]. Plitidepsin possesses antiviral activity and is against SARS-CoV-2 with an IC 90 of 0.88 nM. Plitidepsin is usually used for multiple myeloma and advanced cancer research, and has the potential for COVID-19 research [1] [2]. Uses: Scientific research. Group: Peptides. Alternative Names: Aplidine; PM90001. CAS No. 137219-37-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16050.
Plitidepsin
Plitidepsin. Uses: Designed for use in research and industrial production. Product Category: Coronavirus and Solid Tumor Clinical Raw Materials. CAS No. 137219-37-5. Purity: >98%. Product ID: ACM137219375. Alfa Chemistry ISO 9001:2015 Certified.
Plitidepsin
Plitidepsin is a cyclic depsipeptide isolated from the marine tunicate Aplidium albicans. Plitidepsin shows potent anticancer activity against a large variety of cultured human cancer cells, inducing apoptosis by triggering mitochondrial cytochrome c release, initiating the Fas/DC95, JNK pathway and activating caspase 3 activation. This agent also inhibits elongation factor 1-a, thereby interfering with protein synthesis, and induces G1 arrest and G2 blockade, thereby inhibiting tumor cell growth. Synonyms: aplidin; aplidine; plitidepsin; dehydrodidemnin B. Grades: >98%. CAS No. 137219-37-5. Molecular formula: C57H87N7O15. Mole weight: 1110.34.
Plixorafenib
PLX8394 is a potent and selective BRaf inhibitor, with an IC 50 of appr 5 nM for BRAF V600E. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PLX8394; FORE8394. CAS No. 1393466-87-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18972.
PLL coated Fe2O3 nanoparticles. Group: Nanopowders. CAS No. 1317-61-9.
PlnA-17
PlnA-17 is an antibacterial peptide isolated from Lactobacillus plantarum. It has activity against gram-positive bacteria. Grades: >95%. Molecular formula: C97H153N25O20. Mole weight: 1989.44.
PlnA-22
PlnA-22 is an antibacterial peptide isolated from Lactobacillus plantarum. It has activity against gram-positive bacteria. Synonyms: Tyr-Ser-Leu-Gln-Met-Gly-Ala-Thr-Ala-Ile-Lys-Gln-Val-Lys-Lys-Leu-Phe-Lys-Lys-Trp-Gly-Trp. Grades: >97%. Molecular formula: C125H195N31O28S. Mole weight: 2612.17.
Plozalizumab
Plozalizumab (MLN-1202) is a specific humanized anti- CCR2 antibody. Plozalizumab can be used for malignant melanoma research [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: MLN-1202. CAS No. 1610761-46-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99781.
PLP (139-151)
PLP (139-151) is amino acid residue 139 to 151 of myelin proteolipid protein (PLP) used to induce experimental autoimmune encephalomyelitis (EAE). Uses: Scientific research. Group: Peptides. CAS No. 131334-43-5. Pack Sizes: 5 mg. Product ID: HY-P0129.
PLP (139-151)
PLP (139-151). Group: Biochemicals. Grades: Purified. CAS No. 122018-58-0. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
PLP 139-151
PLP 139-151 is the 139-151 amino acid residue of myelin protein (PLP), used to induce experimental autoimmune encephalomyelitis (EAE). Synonyms: Myelin Proteolipid Protein (139-151) (depalmitoylated) (human, bovine, dog, mouse, rat); His-Cys-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe; L-histidyl-L-cysteinyl-L-leucyl-glycyl-L-lysyl-L-tryptophyl-L-leucyl-glycyl-L-histidyl-L-prolyl-L-alpha-aspartyl-L-lysyl-L-phenylalanine. Grades: >98%. CAS No. 131334-43-5. Molecular formula: C72H104N20O16S. Mole weight: 1537.79.
PLpro inhibitor
PLpro inhibitor is a potent inhibitor of papain-like protease (PLpro) with an IC 50 of 2.6 μM [1]. PLpro inhibitor inhibits SARS-CoV-2 PLpro with an IC 50 of 5.0 μM and an EC 50 of 21.0 μM [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1093070-14-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-17542.
PLpro inhibitor
Cas No. 1093070-14-4.
PLS-123
PLS-123 is a novel covalent irreversible Bruton's Tyrosine Kinase inhibitor. PLS-123 shows potent anti-proliferative effects in multiple cellular and in vivo preclinical models of B-cell lineage malignancy. PLS-123 may become a drug candidate for treatment of B cell cancers. Uses: B cell cancers. Synonyms: PLS-123; PLS 123; PLS123. N- (2- ( (3- (2-acrylamidoacetamido) phenyl) amino) pyrimidin-5-yl) -2-methyl-5- (3- (trifluoromethyl) benzamido) benzamide. Grades: 98%. CAS No. 1431727-04-6. Molecular formula: C31H26F3N7O4. Mole weight: 617.59.
Plumbagin. Group: Biochemicals. Grades: Purified. CAS No. 481-42-5. Pack Sizes: 50mg. US Biological Life Sciences.
Worldwide
Plumbagin
Plumbagin, a natural 1,4-naphthoquinone first isolated from plants of the genus Plumbago, induces apoptosis in cancer cells. Plumbagin exhibited effective cell growth inhibition via inducing cancer cells to undergo G2/M phase arrest and apoptosis. Synonyms: 5-Hydroxy-2-methyl-1,4-naphthalenedione; 2-Methyljuglone; 5-Hydroxy-2-methyl-1,4-naphthoquinone; NSC 236613; NSC 688284; Plumbagine; Plumbagone. Grades: ≥98% by HPLC. CAS No. 481-42-5. Molecular formula: C11H8O3. Mole weight: 188.18.
Plumbagin
Plumbagin (2-Methyljuglone) is a naphthoquinone isolated from Plumbago zeylanica , exhibits anticancer and antiproliferative activities [1]. Uses: Scientific research. Group: Natural products. Alternative Names: 2-Methyljuglone. CAS No. 481-42-5. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-N1497.
Plumieride
Plumieride is isolated from the herb of Himatanthus fallax. It shows strong fungitoxicity against some dermatophytes. Synonyms: Agoniadin. Grades: 98%. CAS No. 511-89-7. Molecular formula: C21H26O12. Mole weight: 470.42.
Pluracidomycin A1
Pluracidomycin A1 is a carbapenem antibiotic produced by Str. pluracidomyceticus nov. sp. It has anti-gram-positive bacteria and gram-negative bacteria activity, and has the effect of inhibiting β-lactamase. Synonyms: 1-Azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 7-oxo-3-sulfo-6-(1-(sulfooxy)ethyl)-, (5R-(5alpha,6beta(S*)))-; Pluracidomycin; Pluracidomycin A; SF 2103 A. Grades: >98%. CAS No. 82138-64-5. Molecular formula: 9H11NO10S2. Mole weight: 357.31.
Pluracidomycin B
Pluracidomycin B is a carbapenem antibiotic produced by Str. pluracidomyceticus nov. sp. It has anti-gram-positive bacteria and gram-negative bacteria activity, and has the effect of inhibiting β-lactamase. CAS No. 82138-65-6. Molecular formula: C11H13NO10S2. Mole weight: 383.35.
Pluracidomycin C1
Pluracidomycin C1 is a carbapenem antibiotic produced by Str. pluracidomyceticus nov. sp. It has anti-gram-positive bacteria and gram-negative bacteria activity, and has the effect of inhibiting β-lactamase. Synonyms: Pluracidomycin C. CAS No. 82138-66-7. Molecular formula: C10H13NO10S2. Mole weight: 371.34.
Pluraflavin A
Pluraflavin A is an antitumor antibiotic produced by Saccharothrix sp. DSM 12931. Pluraflavin A has the effect of inhibiting the transcription of glucose-6-phosphatase gene and has good anti-proliferation activity on tumor cells. Molecular formula: C43H54N2O14. Mole weight: 822.89.
Pluraflavin C
Pluraflavin C is an antitumor antibiotic produced by Saccharothrix sp. DSM 12931. It has good anti-proliferation activity on tumor cells. Molecular formula: C43H56N2O15. Mole weight: 840.91.
Pluraflavin E
Pluraflavin E is an antitumor antibiotic produced by Saccharothrix sp. DSM 12931. It has good anti-proliferation activity on tumor cells. Molecular formula: C36H41NO14. Mole weight: 711.71.
Pluripotin
Pluripotin is a dual inhibitor of ERK1 and RasGAP with K D s of 98 nM and 212 nM, respectively. Pluripotin also inhibits RSK1 , RSK2 , RSK3 , and RSK4 with IC 50 s of 0.5, 2.5, 3.3, and 10.0 μM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SC1. CAS No. 839707-37-8. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10579.
SC1 (Pluripotin) was identified in a cell-based chemical library screen for small molecules that regulate mouse embryonic stem (ES) cell self-renewal. SC1 is sufficient to sustain long-term self-renewal of mouse ES cells in an undifferentiated state in the absence of LIF, feeder cells, or serum. SC1 acts through dual inhibition of extracellular signal-regulated kinase 1 (ERK1) and Ras GTPase-activating protein (Ras-GAP). Mouse ES cells maintained in the presence of SC1 retain their ability to differentiate into cells representing all three germ layers in vitro, form chimeric mouse, and contribute to germ line in vivo. Uses: Self-renewal. Synonyms: SC-1; SC 1; SC1; Pluripotin. Grades: 0.98. CAS No. 839707-37-8. Molecular formula: C27H25F3N8O2. Mole weight: 550.54.
Pluripotin
Pluripotin is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP. Pluripotin has been shown to maintain embryonic stem cell (ESC) self-renewal. When combined with leukemia inhibitory factor, Pluripotin greatly promotes derivation of embryonic stem cell lines from refractory strains. Group: Biochemicals. Alternative Names: N-[3-[7-[ (1, 3-Dimethyl-1H-pyrazol-5-yl) amino]-1, 4-dihydro-1-methyl-2-oxopyrimido[4, 5-d]pyrimidin-3 (2H) -yl]-4-methylphenyl]-3- (trifluoromethyl) benzamide; N-[3-[7- (2, 5-Dimethyl-2H-pyrazol-3-ylamino) -1-methyl-2-oxo-1, 4-dihydro-2H-pyrimido[4, 5-d]pyrimidin-3-yl]-4-methylphenyl]-3-trifluoromethyl-benzamide; SC 1; Stemolecule SC 1. Grades: Highly Purified. CAS No. 839707-37-8. Pack Sizes: 2.5mg. US Biological Life Sciences.