A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
P-3355 is antibacterial and antifungal antibiotic produced by streptomyces amylovorus. Synonyms: Antibiotic P 3355; P 3355. CAS No. 60046-57-3. Molecular formula: C7H9NO2. Mole weight: 139.15.
p38α inhibitor 3 (Comp G7) is a p38α inhibitor that blocks the effectiveness of myoblast differentiation [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 260428-69-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153002.
p38α inhibitor 5
p38α inhibitor 5 (compound 1) is a PROTAC-type target protein ligand targeting p38 and can be used to synthesize NR-11c (HY-159798) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2550397-96-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-159799.
p38 MAPK-IN-1
p38 MAPK-IN-1, a naphthyridine N-oxide, is a novel potent and selective inhibitor of p38 MAPK and it was found to have proper balance between potency and pharmacokinetics and excellent action in a chronic model of arthritis for further study in some sorts. Uses: P38 mapk-in-1 is a novel potent and selective inhibitor of p38 mapk and could be useful in studying some sorts of inflammatory conditions. Synonyms: p38alpha-IN-4; p38alpha IN 4; p38alphaIN4; p38alpha inhibitor 4; p38alpha-inhibitor-4; p38 MAP Kinase Inhibitor XI; P38 MAPK-IN-1; CHEMBL1916344; SCHEMBL2077831; BDBM50357886; HY-12839; HY 12839; HY12839. Grades: 95%. CAS No. 1006378-90-0. Molecular formula: C21H15F2N2O. Mole weight: 349.35.
p38 MAPK-IN-2
An inhibitor of p38 kinase. Synonyms: Ethanone, 1-[4-[5-(4-chloro-2-fluorophenyl)-4-(4-pyrimidinyl)-1H-pyrazol-3-yl]-1-piperidinyl]-2-hydroxy-; 1-[4-[3-(4-chloro-2-fluorophenyl)-4-pyrimidin-4-yl-1H-pyrazol-5-yl]piperidin-1-yl]-2-hydroxyethanone. CAS No. 635725-16-5. Molecular formula: C20H19ClFN5O2. Mole weight: 415.85.
p38 MAPK-IN-4
p38 MAPK-IN-4 (compound 6) is a p38 MAPK inhibitor with an 50 of 35 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 219138-24-6. Pack Sizes: 500 μg; 1 mg; 5 mg; 10 mg. Product ID: HY-112466.
p38 MAP Kinase Inhibitor IV
p38 MAP Kinase Inhibitor IV is a highly specific ATP-competitive p38α MAPK inhibitor with IC 50 s of 0.13 and 0.55 μM for p38α and p38β MAPK, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1638-41-1. Pack Sizes: 5 mg. Product ID: HY-112401.
p38 MAP Kinase Inhibitor XI (4-(2,4-Difluorophenyl)-8-(2-methylphenyl)-1,7-naphthyridine-7-oxide, 4-(2,4-Difluorophenyl)-8-o-tolyl-1,7-naphthyridine-7-oxide)
A cell-permeable naphthyridine N-oxide compound that acts as a potent, reversible p38alpha MAP kinase inhibitor (IC50 = 68nM) and exhibits excellent selectivity among 54-kinases. It acts on the ATP-binding site plus an adjacent hydrophobic pocket. Exhibits desirable ADME (Absorption, Distribution, Metabolism, and Excretion) profile with good microsomal stability, low toxicity, and low reactivity towards cytochrome P450 isozymes. Shown to inhibit lipopolysaccharide-induced TNF-alpha production in a dose-dependent manner (ED50 of 0.5mg/kg). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
A cell-permeable phenylamino-dibenzosuberone-diol with a rigid molecular structure specifically designed to target hydrophobic region I in p38alpha & p38beta, but not in other kinases with bulky entrance-blocking gatekeeper residues. Shown to selectively inhibit p38alpha (IC50 = 5nM; [ATP] = 100uM) and p38beta (97% inhibition at 1uM), while exhibiting little affinity toward 400 other kinase constructs, including p38delta, p38upsilon, Erk1/2/3/4/5/8, JNK1/2/3, and MEK1/2/3/4/6. Shown to prevent cellular HSP27 Ser82 phosphorylation upon p38 activation by Anisomycin in HeLa (IC50 = 25nM) or by TNF-alpha in THP-1 cultures. Unlike the ATP-binding site-targeting BIRB 796 and SB 203580, Skepinone-L does not inhibit JNK-mediated c-Jun or ERK-dependent CREB phosphorylation in THP-1 cultures. Oral administration to D-Gal-sensitized mice is reported to greatly reduce plasma TNF-alpha production upon LPS challenge (by 77%; 3mg/kg p.o.) in vivo. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
p38 MAPK Inhibitor
p38 MAPK inhibitor is a potent inhibitor of p38 MAP kinase with IC50 value of 35 nM. Synonyms: p38 MAP Kinase Inhibitor; p38 Mitogen-activated Protein Kinase Inhibitor; 2-(4-chlorophenyl)-4-(4-fluorophenyl)-5-pyridin-4-yl-1H-pyrazol-3-one. Grades: ≥98%. CAS No. 219138-24-6. Molecular formula: C20H13ClFN3O. Mole weight: 365.8.
p38 MAPK Inhibitor IV
p38 MAPK inhibitor IV is an ATP-competitive inhibitor of p38α/β MAP kinases with IC50 values of 0.13, 0.55, 5.47, and 8.63 μM for p38α, p38β, p38??, and p38δ, respectively. Synonyms: p38 MAP Kinase Inhibitor IV; p38 Mitogen-activated Protein Kinase Inhibitor IV; 2,2'-sulfonylbis(3,4,6-trichlorophenol); 3,4,6-trichloro-2-(2,3,5-trichloro-6-hydroxyphenyl)sulfonylphenol. Grades: ≥98%. CAS No. 1638-41-1. Molecular formula: C12H4Cl6O4S. Mole weight: 456.9.
P51 Polycarbonate 3D Printing Filament. Group: 3d printing materials.
p53 (103-111)
P53 has been described as ''the guardian of the genome'' because of its role in conserving stability by preventing genome mutation. Suppression of p53 in human breast cancer cells is shown to lead to increased CXCR5 chemokine receptor gene expression and activated cell migration in response to chemokine CXCL13. Synonyms: Cellular tumor antigen p53 (103-111); NY-CO-13 (103-111); Tumor suppressor p53 (103-111).
p53 (139-147)
P53 has been described as ''the guardian of the genome'' because of its role in conserving stability by preventing genome mutation. Suppression of p53 in human breast cancer cells is shown to lead to increased CXCR5 chemokine receptor gene expression and activated cell migration in response to chemokine CXCL13. Synonyms: Cellular tumor antigen p53 (139-147); NY-CO-13 (139-147); Tumor suppressor p53 (139-147).
p53 (149-157)
P53 has been described as ''the guardian of the genome'' because of its role in conserving stability by preventing genome mutation. Suppression of p53 in human breast cancer cells is shown to lead to increased CXCR5 chemokine receptor gene expression and activated cell migration in response to chemokine CXCL13. Synonyms: Cellular tumor antigen p53 (149-157); NY-CO-13 (149-157); Tumor suppressor p53 (149-157).
p53 17-26
P53 (17-26) is the 17-26 amino acid fragment of P53. P53 (17-26) is the mdm-2-binding domain. Synonyms: H-Glu-Thr-Phe-Ser-Asp-Leu-Trp-Lys-Leu-Leu-OH; L-alpha-glutamyl-L-threonyl-L-phenylalanyl-L-seryl-L-alpha-aspartyl-L-leucyl-L-tryptophyl-L-lysyl-L-leucyl-L-leucine; (2S, 5S, 8S, 11S, 14S, 17S, 20S, 23S, 26S, 29S)-11-((1H-indol-3-yl)methyl)-29-amino-8-(4-aminobutyl)-23-benzyl-17-(carboxymethyl)-26-((R)-1-hydroxyethyl)-20-(hydroxymethyl)-2, 5, 14-triisobutyl-4, 7, 10, 13, 16, 19, 22, 25, 28-nonaoxo-3, 6, 9, 12, 15, 18, 21, 24, 27-nonaazadotriacontane-1, 32-dioic acid. Grades: ≥95%. CAS No. 488118-64-5. Molecular formula: C60H90N12O17. Mole weight: 1251.43.
p53 and MDM2 proteins-interaction-inhibitor chiral
p53 and MDM2 proteins-interaction-inhibitor chiral is an inhibitor of the interaction between p53 and MDM2 proteins. Synonyms: 2-[4-[[(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-(1,1-dimethylethyl)-2-ethoxyphenyl]-4,5-dihydro-4,5-dimethyl-1H-imidazol-1-yl]carbonyl]-1-piperazinyl]-1-(4-morpholinyl)Ethanone;Ethanone, 2-[4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-2-[4-(1,1-dimethylethyl)-2-ethoxyphenyl]-4,5-dihydro-4,5-dimethyl-1H-imidazol-1-yl]carbonyl]-1-piperazinyl]-1-(4-morpholinyl)-, rel-;p53 and MDM2 proteins-interaction-inhibitor. Grades: 95%. CAS No. 939981-37-0. Molecular formula: C40H49Cl2N5O4. Mole weight: 734.76.
p53 and MDM2 proteins-interaction-inhibitor dihydrochloride
p53 and MDM2 proteins-interaction-inhibitor dihydrochloride is an inhibitor of the interaction between p53 and MDM2 proteins. Uses: Scientific research. Group: Signaling pathways. CAS No. 2070009-27-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 100 mg. Product ID: HY-70027A.
p53 and MDM2 proteins-interaction-inhibitor racemic
p53 and MDM2 proteins-interaction-inhibitor racemic is an inhibitor of the interaction between p53 and MDM2 proteins. Synonyms: rel-2-[4-[[(4R,5S)-4,5-Bis(4-chlorophenyl)-2-[4-(1,1-dimethylethyl)-2-ethoxyphenyl]-4,5-dihydro-4,5-dimethyl-1H-imidazol-1-yl]carbonyl]-1-piperazinyl]-1-(4-morpholinyl)ethanone;Ethanone, 2-[4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-2-[4-(1,1-diMethylethyl)-2-ethoxyphenyl]-4,5-dihydro-4,5-diMethyl-1H-iMidazol-1-yl]carbonyl]-1-piperazinyl]-1-(4-Morpholinyl)-;2-[4-[(4R,5S)-2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethylimidazole-1-carbonyl]piperazin-1-yl]-1-morpholin-4-ylethanone. Grades: 95%. CAS No. 939983-14-9. Molecular formula: C40H49Cl2N5O4. Mole weight: 734.76.
p53-MDM2-IN-1
p53-MDM2-IN-1 (Example 30) is an inhibitor of p53-MDM2/X protein interaction with an K i value of 23.35 μM. p53-MDM2-IN-1 can be used for anti-tumor research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 381717-91-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-W340839.
p53-MDM2-IN-4
p53-MDM2-IN-4 (Example 4) is an inhibitor of p53-MDM2/X protein interaction, with a K i value of 3.079 μM. p53-MDM2-IN-4 can be used in anti-tumor research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 350678-63-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W340313.
P57
Hoodia gordonii. Group: Steroids. CAS No. 384329-61-7. Mole weight: 879.08. Appearance: White powder. Purity: 0.907. Catalog: ACM384329617.
p5 Ligand for Dnak and DnaJ acetate
p5 Ligand for Dnak and DnaJ acetate is a high-affinity ligand for DnaK (E. coli Hsp70) and DnaJ (E. coli Hsp40) and corresponds to the main binding site of the 23 residues part of the prosequence of mitochondrial aspartate aminotransferase. Synonyms: H-Cys-Leu-Leu-Leu-Ser-Ala-Pro-Arg-Arg-OH.CH3CO2H; L-Cysteinyl-L-leucyl-L-leucyl-L-leucyl-L-seryl-L-alanyl-L-prolyl-L-arginyl-L-arginine acetate salt; L-cysteinyl-L-leucyl-L-leucyl-L-leucyl-L-seryl-L-alanyl-L-prolyl-L-arginyl-L-arginine acetic acid. Grades: ≥95%. CAS No. 2803415-96-3. Molecular formula: C44H81N15O11S.C2H4O2. Mole weight: 1088.33.
P-725C is a prostaglandin synthetase inhibitor produced by Penicillum thomii. Synonyms: 6-Hydroxy-2-methyl-5-(1-oxopropyl)-2H-1,4-oxazine-3-carboxylic acid. CAS No. 87979-96-2. Molecular formula: C9H11NO5. Mole weight: 213.19.
P7C3
P7C3. Group: Biochemicals. Grades: Purified. CAS No. 301353-96-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
P7C3
P7C3 is a proneurogenic and neuroprotective agent that activates NAMPT. P7C3 protects neurons from apoptosis and promotes neurogenesis in mice. It also improves cognitive function and memory in aged mice. Synonyms: 1-Anilino-3-(3,6-dibromocarbazol-9-yl)propan-2-ol; 1-(3,6-Dibromo-carbazol-9-yl)-3-phenylamino-propan-2-ol; 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(phenylamino)propan-2-ol; 1-(3,6-dibromocarbazol-9-yl)-3-(phenylamino)propan-2-ol. Grades: >98%. CAS No. 301353-96-8. Molecular formula: C21H18Br2N2O. Mole weight: 474.196.
P7C3-A20
P7C3-A20, an analogue of P7C3, is a neuroprotective compound which inhibits mature neuronal cell death while also increasing the net magnitude of postnatal neurogenesis in models of neurodegeneration and acute injury. Synonyms: N-(3-(3,6-dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-3-methoxyaniline; P7C-3A20; P7C3A20; P7C 3A20. CAS No. 1235481-90-9. Molecular formula: C22H19Br2FN2O. Mole weight: 506.21.
P7C3-A20
P7C3-A20. Group: Biochemicals. Alternative Names: N-(3-(3,6-Dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-3-methoxyaniline. Grades: Highly Purified. CAS No. 1235481-90-9. Pack Sizes: 100mg, 250mg, 500mg, 1g. US Biological Life Sciences.
Worldwide
P7C3-A20 analog
P7C3-A20 demonstrated greater proneurogenic efficacy than a wide spectrum of currently marketed antidepressant drugs. P7C3-A20 showed neuroprotective properties in rodent models of Parkinson's disease, amyotrophic lateral sclerosis, traumatic brain injury and age-related cognitive decline. Synonyms: P7C3-A20 analog; P7C3A20 analog; P7C3-A20-analog; defluoro-P7C3-A20. Grades: 98%. Molecular formula: C22H20Br2N2O. Mole weight: 488.22.
P7C3-A20 hydrochloride
P7C3-A20 is an analogue of P7C3, and is a proneurogenic, neuroprotective agent. P7C3-A20 displayed increased activity and an improved toxicity profile compared to P7C3. Synonyms: P7C-3A20; P7C3A20; P7C 3A20. Grades: 98%. CAS No. 1485572-67-5. Molecular formula: C22H20Br2ClFN2O. Mole weight: 542.67.
P7C3-OMe
P7C3-OMe, also known as (R)-P7C3-OMe, is a methoxy derivative of parent compound P7C3, an aminopropyl carbazole that exhibits antidepressant and neuroprotective activities. P7C3 inhibits MPTP-induced neuronal death in animal models of Parkinson's disease and delays the onset and preserves motor function in animal models of amyotrophic lateral sclerosis (ALS). Synonyms: (2R)-1-(3,6-dibromocarbazol-9-yl)-3-(3-methoxyanilino)propan-2-ol; P7C3-OMe; (R)-P7C3-OMe. CAS No. 1235481-43-2. Molecular formula: C22H20Br2N2O2. Mole weight: 504.22.
P9
P9 is an antimicrobial peptide found in Cervus elaphus (New Zealand red deer), and has antibacterial activity. Grades: >98%.
PA-1329-E1
PA-1329-E1 is a nucleoside antibiotic produced by Micromonospora sp. PA-1329. It exhibits activity against Candida albicans. Synonyms: Antibiotic PA-1329-E1. CAS No. 80860-79-3. Molecular formula: C15H23N7O5. Mole weight: 381.39.
PA 1 dihydrochloride
PA 1 dihydrochloride is a photoswitchable epithelial sodium channel blocker with IC50 values of 90 and 390 nM for αβγ and δβγENaCs in the trans conformation. Synonyms: PA 1 dihydrochloride; PA-1 dihydrochloride; PA1 dihydrochloride; 3,5-Diamino-6-chloro-N-[imino[[4-(2-phenyldiazenyl)phenyl]amino]methyl]-2-pyrazinecarboxamide dihydrochloride. Grades: ≥98% by HPLC. Molecular formula: C18H16ClN9O.2HCl. Mole weight: 482.75.
PA (224-233), Influenza
PA (224-233), Influenza, a 10-aa peptide, is a fragment of polymerase 2 protein in influenza A virus. Synonyms: Ser-Ser-Leu-Glu-Asn-Phe-Arg-Ala-Tyr-Val; L-seryl-L-seryl-L-leucyl-L-alpha-glutamyl-L-asparagyl-L-phenylalanyl-L-arginyl-L-alanyl-L-tyrosyl-L-valine. Grades: ≥95%. CAS No. 271573-27-4. Molecular formula: C53H80N14O17. Mole weight: 1185.29.
PA-31088-II
PA-31088-II is a carbapenem antibiotic produced by Streptomyces tokunonensis PA-31088 and Str. argenteolus PA-39504. Molecular formula: C13H16N2O6S. Mole weight: 328.34.
PA-32413-I
PA-32413-I is a beta-lactam antibiotic produced by Streptomyces clavuigerus PA-32413. It is active against gram-positive and gram-negative bacteria. Synonyms: PA-32413 I; PA 32413 I. Molecular formula: C18H25N5O10S. Mole weight: 503.48.
PA452
PA452, retinoic X receptor ( RXR ) specific antagonist, inhibits the effect of Retinoic acid (RA) on Th1/Th2 development [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 457657-34-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-108522.
PA 452
PA 452. Group: Biochemicals. Grades: Purified. CAS No. 457657-34-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
PA 452
PA 452 is a RXR antagonist. It can attenuate cell proliferation and induce apoptosis in MCF-7 breast cancer cells. Synonyms: PA-452; PA 452; PA452; 2-[[3-(Hexyloxy)-5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl]methylamino]-5-pyrimidinecarboxylic acid. Grades: ≥98% by HPLC. CAS No. 457657-34-0. Molecular formula: C26H37N3O3. Mole weight: 439.59.
PA-46101 A
PA-46101 A is a macrolide antibiotic isolated from the culture broth of Streptomyces sp. PA-46101. It is active in vitro against anaerobic Gram-positive and Gram-negative bacteria and also against a limited number of aerobic Gram-positive bacteria. Synonyms: PA 46101 A. CAS No. 130743-11-2. Molecular formula: C52H70O18. Mole weight: 983.1.
PA-46101 B
PA-46101 B is a macrolide antibiotic isolated from the culture broth of Streptomyces sp. PA-46101. It is active in vitro against anaerobic Gram-positive and Gram-negative bacteria and also against a limited number of aerobic Gram-positive bacteria. Synonyms: PA 46101 B. CAS No. 130812-34-9. Molecular formula: C61H86O22. Mole weight: 1171.3.
PA 8
PA 8 is a PAC1 receptor antagonist. It attenuates the second phase of formalin-induced nociceptive responses to relieve the inflammatory pain in mice. Synonyms: 2-Amino-5,8-dihydro-5-[3-methoxy-4-(2-propen-1-yloxy)phenyl]pyrido[2,3-d]pyrimidine-4,7(3H,6H)-dione; 2-amino-5-(3-methoxy-4-prop-2-enoxyphenyl)-3,6-dihydropyrido[2,3-d]pyrimidine-4,7-dione. Grades: ≥98% by HPLC. CAS No. 878437-15-1. Molecular formula: C17H18N4O4. Mole weight: 342.35.
PA-8
PA-8 is a potent, selective and orally active PACAP type I (PAC1) receptor antagonist. PA-8 inhibits the phosphorylation of CREB induced by PACAP in PAC1 -, but not VPAC1- or VPAC2-receptor. PA-8 also inhibits PACAP-induced cAMP elevation with an IC 50 of 2 nM [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 878437-15-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-133529.
PA-824
PA-824, a bioreductive drug. PA-824 has potent in vitro activity against Mycobacterium tuberculosis. PA-824 was tested in vitro against a broad panel of multidrug-resistant clinical isolates and was found to be highly active against all isolates (MIC<1 microg/ml). PA-824 showed significant activity at 2, 10, and 50 microg/ml, similar to that of metronidazole, in a dose-dependent manner. Synonyms: PA824; PA-824; PA 824; Pretomanid. Grades:>98%. CAS No. 187235-37-6. Molecular formula: C14H12F3N3O5. Mole weight: 359.26.
PA-9
PA-9 is a pituitary adenylate cyclase-activating polypeptide (PACAP) type I ( PAC1 ) receptor antagonist. PA-9 dose dependently inhibits PACAP-induced cAMP elevation with an IC 50 of 5.6 nM. PA-9 can be used for the research of neuropathic and/or inflammatory pain [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1436004-46-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-129421.
Pa-AMP2
Pa-AMP2 is an antimicrobial peptide found in pokeweed seeds, Phytolacca americana, and has anti-gram-positive bacteria and fungal activity. Synonyms: Phytolacca americana antimicrobial peptide 2. Grades: >98%.
PAB-Ertapenem Impurity
An impurity of Ertapenem. Ertapenem is a carbapenem antibiotic. Synonyms: (4R,5S,6S)-3-(((3R,5S)-1-(4-aminobenzyl)-5-((3-carboxyphenyl)carbamoyl)pyrrolidin-3-yl)thio)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid. Grades: > 95%. Molecular formula: C29H30N4O7S. Mole weight: 578.65.
PAβN dihydrochloride
PAβN dihydrochloride is an efflux pump inhibitor and a substrate for dipeptidyl aminopeptidase I (cathepsin C). Synonyms: H-Phe-Arg-βNA.2HCl; Phe-Arg β-naphthylamide dihydrochloride. Grades: ≥ 99% (TLC). CAS No. 100929-99-5. Molecular formula: C25H32Cl2N6O2. Mole weight: 519.47.
Pabinafusp alfa
Pabinafusp alfa (JR-141) is a transferrin receptor -targeting antibody consisting of Iduronate 2-sulfatase (HY-P76399) and an anti-human transferrin receptor antibody. Pabinafusp alfa is blood-brain permeable and prevents heparan sulfate (HS) deposition in the central nervous system of mucopolysaccharidosis II (MPS II) mice. Pabinafusp alfa improves learning and prevents central nervous system neuronal damage in mice [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: JR-141. CAS No. 2140211-48-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99797.
Pabociclib Impurity B
An impurity of Palbociclib, a selective inhibitor of cyclin-dependent kinases CDK4 and CDK6. Palbociclib is developed for the treatment of ER-positive and HER2-negative breast cancer. Synonyms: tert-butyl 4-[6-[(6-acetyl-8-cyclopentyl-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]pyridin-3-yl]piperazine-1-carboxylate. Grades: >95%. CAS No. 1651214-74-2. Molecular formula: C29H37N7O4. Mole weight: 547.66.
Pabociclib Impurity B Hydrochloride
An impurity of Palbociclib, a selective inhibitor of cyclin-dependent kinases CDK4 and CDK6. Palbociclib is developed for the treatment of ER-positive and HER2-negative breast cancer. Synonyms: tert-butyl 4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate hydrochloride. CAS No. 1883672-48-7. Molecular formula: C29H38ClN7O4. Mole weight: 584.11.
PAC1
PAC1. Group: Biochemicals. Alternative Names: 4-(Phenylmethyl)-1-piperazineacetic acid [ [2-hydroxy-3- (2-propenyl) phenyl] methylene] hydrazide. Grades: Highly Purified. CAS No. 315183-21-2. Pack Sizes: 2g, 5g, 10g, 25g, 50g. Molecular Formula: C23H28N4O2. US Biological Life Sciences.
Worldwide
PAC 1
PAC 1. Group: Biochemicals. Grades: Purified. CAS No. 315183-21-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
PAC-1
PAC-1 is a procaspase-3 activator that induces apoptosis in cancer cells with an EC 50 of 2.08 μM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Procaspase activating compound 1. CAS No. 315183-21-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-13523.
PAC-1
PAC-1 is known as the first procaspase activating compound, which selectively induces apoptosis, or cell suicide, in cancerous cells. PAC-1 has shown good results in mouse models and is being further evaluated for use in humans. In 2010 a published study showed PAC-1 to be safe to research dogs, and a second study published later that same year reported that a PAC-1 derivative (called S-PAC-1) was well tolerated in a small Phase I Clinical Trial of pet dogs with lymphoma. Even at low doses of S-PAC-1, tumors regressed in 1/6 dogs, and the disease was stabilized (no additional tumor growth) in 3/6 dogs. Synonyms: 1-Piperazineacetic acid, 4-(phenylmethyl)-, 2-[[2-hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide; 1-Piperazineacetic acid, 4-(phenylmethyl)-, [[2-hydroxy-3-(2-propenyl)phenyl]methylene]hydrazide; PAC 1; PAC1; Procaspase activating compound 1. Grades: >98%. CAS No. 315183-21-2. Molecular formula: C23H28N4O2. Mole weight: 392.49.
PAC-1
PAC-1. Group: Biochemicals. Alternative Names: 4-(Phenylmethyl)-1-piperazineacetic Acid (2E) -2- [ [2-Hydroxy-3- (2-propen-1-yl) phenyl] methylene] hydrazide. Grades: Highly Purified. CAS No. 1044929-62-5. Pack Sizes: 10mg, 25mg, 50mg, 100mg, 250mg. Molecular Formula: C23H28N4O2. US Biological Life Sciences.
Worldwide
PAC-113
PAC-113 an anti-fungal, for the treatment of oral candidiasis infections. Molecular formula: C71H109N27O14. Mole weight: 1564.82.
Pac-2-Amino-dA-CE Phosphoramidite
Pac-2-Amino-dA-CE Phosphoramidite, a necessary component of DNA synthesis, plays a vital role in the modification of oligonucleotides. Its indispensability lies in acting as a critical mediator in the development of DNA analogs, oligos and probes employed in manifold biomedical research. These investigations focus on understanding pathogenic conditions such as cancer, genetic disorders and infectious diseases, and Pac-2-Amino-dA-CE Phosphoramidite brings cutting-edge insights to these fields. Synonyms: 5'-Dimethoxytrityl-N2-phenoxyacetyl-N6-di-n-butylaminomethylidene-2,6-diamino-2'-deoxypurine riboside-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite. Molecular formula: C57H72N9O8P. Mole weight: 1042.21.
PACAP 1-27
PACAP 1-27. Group: Biochemicals. Grades: Purified. CAS No. 127317-03-7. Pack Sizes: 100ug. US Biological Life Sciences.
Worldwide
PACAP (1-27), human, ovine, rat
PACAP (1-27), human, ovine, rat (PACAP 1-27) is the N-terminal fragment of PACAP-38, and is a potent PACAP receptor antagonist with IC 50 s of 3 nM, 2 nM and 5 nM for rat PAC1 , rat VPAC1 and human VPAC2 , respectively [1]. Uses: Scientific research. Group: Peptides. Alternative Names: PACAP 1-27. CAS No. 127317-03-7. Pack Sizes: 500 μg; 1 mg; 5 mg; 10 mg. Product ID: HY-P0176.
PACAP (1-27), human, ovine, rat
Pituitary adenylate cyclase activating polypeptide (PACAP 1-27) is an endogenous neuropeptide showing considerable homology with vasoactive intestinal peptide (VIP). It is a potent PACAP receptor agonist. Synonyms: PACAP 1-27; Pituitary Adenylate Cyclase Activating Polypeptide1-27; H-His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-NH2; L-histidyl-L-seryl-L-alpha-aspartyl-glycyl-L-isoleucyl-L-phenylalanyl-L-threonyl-L-alpha-aspartyl-L-seryl-L-tyrosyl-L-seryl-L-arginyl-L-tyrosyl-L-arginyl-L-lysyl-L-glutaminyl-L-methionyl-L-alanyl-L-valyl-L-lysyl-L-lysyl-L-tyrosyl-L-leucyl-L-alanyl-L-alanyl-L-valyl-L-leucinamide. Grades: ≥98% by HPLC. CAS No. 127317-03-7. Molecular formula: C142H224N40O39S. Mole weight: 3147.60.
PACAP (1-27), human, ovine, rat acetate
PACAP (1-27), human, ovine, rat acetate is a neuropeptide originally isolated from the bovine hypothalamus, also found in humans and rats. It is a potent PACAP receptor agonist. Synonyms: H-His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-NH2.CH3CO2H; L-histidyl-L-seryl-L-alpha-aspartyl-glycyl-L-isoleucyl-L-phenylalanyl-L-threonyl-L-alpha-aspartyl-L-seryl-L-tyrosyl-L-seryl-L-arginyl-L-tyrosyl-L-arginyl-L-lysyl-L-glutaminyl-L-methionyl-L-alanyl-L-valyl-L-lysyl-L-lysyl-L-tyrosyl-L-leucyl-L-alanyl-L-alanyl-L-valyl-L-leucinamide acetic acid; Pituitary adenylate cyclase-activating peptide-27 (sheep) acetate. Grades: ≥95%. Molecular formula: C144H228N40O41S. Mole weight: 3207.71.