A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
The PI 3-K? Inhibitor IV, also referenced under CAS 1188890-32-5, controls the biological activity of PI 3-K?. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy.
PI 3-K inhibitor IX, PIK-90 - CAS 677338-12-4
The PI 3-K inhibitor IX, PIK-90, also referenced under CAS 677338-12-4, controls the biological activity of PI 3-K. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy.
PI3K? Inhibitor, SW30
The PI3K? Inhibitor, SW30 controls the biological activity of PI3K?. This small molecule/inhibitor is primarily used for Membrane applications. Group: Fluorescence/luminescence spectroscopy.
PI 3-K? Inhibitor VII - CAS 6318-41-8
The PI 3-K? Inhibitor VII, also referenced under CAS 6318-41-8, controls the biological activity of PI 3-K?. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy.
PI 3-K? Inhibitor VIII - CAS 372196-77-5
The PI 3-K? Inhibitor VIII controls the biological activity of PI 3-K?. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy.
PI 3-K? Inhibitor VI, TGX-221 - CAS 663619-89-4
The PI 3-K? Inhibitor VI, TGX-221, also referenced under CAS 663619-89-4, controls the biological activity of PI 3-K?. This small molecule/inhibitor is primarily used for Cell Signaling applications. Group: Fluorescence/luminescence spectroscopy.
PI 3-K? Inhibitor X, IC87114 - CAS 371242-69-2
The PI 3-K? Inhibitor X, IC87114, also referenced under CAS 371242-69-2, controls the biological activity of PI 3-K?. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy.
PI 3-K Inhibitor XI, HWT - CAS 58053-83-1
The PI 3-K Inhibitor XI, HWT, also referenced under CAS 58053-83-1, controls the biological activity of PI 3-K. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy.
PI 3-K Inhibitor XVIII (p110 beta-G beta gamma Interaction Inhibitor peptide, Cell-permeable, Myr-N-KAAEIASSDSANVSSRGGKKFL PV-NH2)
An N-myristoylated cell-permeable PI 3-K p110 beta-derived G beta-gamma-binding peptide (aa514-537 in p110 beta C2-helical linker region) that prevents G beta-gamma-, but not RTK-, mediated p100 beta activation both in cell-free assays (1uM) and in cultures (30uM in p110 beta/p85/Akt/G beta-gamma-transfected HEK 293E cells) without affecting basal p100 beta activity, p110 beta-Rab5 interaction, nor G beta-gamma-dependent activation of adenylyl cyclase or p101-p110-gamma dimer. The ATP-competitive p110 beta inhibitior TGX-221 can be used in conjunction for studying G beta-gamma dependency of p110 beta-mediated cellular functions. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
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PI 3-K?/? Inhibitor XV, SW-14
The PI 3-K?/? Inhibitor XV, SW-14 controls the biological activity of PI 3-K?/?. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy.
PI 3-K/mTOR Inhibitor III, PKI-179 - CAS 1197160-28-3
The PI 3-K/mTOR Inhibitor III, PKI-179, also referenced under CAS 1197160-28-3, controls the biological activity of PI 3-K/mTOR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy.
PI 3-K/PDK-1 Inhibitor, NVP-BAG956 - CAS 853910-02-8
The PI 3-K/PDK-1 Inhibitor, NVP-BAG956, also referenced under CAS 853910-02-8, controls the biological activity of PI 3-K/PDK-1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy.
PI3Ky inhibitor 1
PI3Ky inhibitor 1 is a potent PI3Ky inhibitor. Synonyms: 1172118-03-4; PI3Kgamma inhibitor 1; CHEMBL2216897N-(6-(4-Amino-1-((8-methyl-1-oxo-2-(o-tolyl)-1,2-dihydroisoquinolin-3-yl)-methyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)benzo[d]thiazol-2-yl)acetamide; N-[6-[4-amino-1-[[8-methyl-2-(2-methylphenyl)-1-oxoisoquinolin-3-yl]methyl]pyrazolo[3,4-d]pyrimidin-3-yl]-1,3-benzothiazol-2-yl]acetamide. Grades: >98%. CAS No. 1172118-03-4. Molecular formula: C32H26N8O2S. Mole weight: 586.67.
PI4KIIIbeta-IN-10, a potent anti-viral agent, is a highly PI4KIIIβ inhibitor with weak inhibition of PI3KC2γ (IC50 ~1 μM), PI3Kα (~10 μM), and PI4KIIIα (~3 μM), and <20% inhibition at concentrations up to 20 μM for PI4K2α, PI4K2β, and PI3K&beta. Synonyms: N-[5-[3-[(4-hydroxyphenyl)sulfamoyl]-4-methoxyphenyl]-4-methyl-1,3-thiazol-2-yl]-2,2-dimethylpropanamide PI4KIIIbeta-IN-10 SCHEMBL14851574. CAS No. 1881233-39-1. Molecular formula: C22H25N3O5S2. Mole weight: 475.58.
PI4KIIIbeta-IN-9
PI4KIIIbeta-IN-9, a thiazole derivative, is a selective PI4KIIIβ inhibitor over PI3Kγ (>140-fold) and PI3Kδ (>20-fold). Studies shows that this compounds may be formulated or provided to a subject in combination with a second anti-infective agent. IC50: P. Synonyms: N- [5- [3- [ (4-hydroxyphenyl) sulfamoyl] -4-methoxyphenyl] -4-methyl-1, 3-thiazol-2-yl] cyclopentanecarboxamidePI4KIIIbeta-IN-9SCHEMBL14851744CS-5620; HY-19798; CS 5620; HY 19798; CS5620; HY19798; 5S8. CAS No. 1429624-84-9. Molecular formula: C23H25N3O5S2. Mole weight: 487.59.
PI4KIII β inhibitor 3
The most effective test compound, the compound of formula 3 (PI4KIII beta inhibitor 3), inhibited IL2 and IFNy secretion with IC50 values of less than 1 nM in each case. Thus, the compound of formula (3) was shown to be as effective at inhibiting IL2 and IFNy secretion as conventional immunosuppressants such as cyclosporine A. IC50 on IFNy and IL-2 release of Cyclosporine A are 2nM and less than 1 nM respectively. Twelve animals received daily treatment with vehicle (1%methylcellulose), twelve others received PI4KIII beta inhibitor 3 at 40 mg/kg/d in 1% methylcellulose. Synonyms: PI4KIII beta inhibitor 3. Grades: >98%. CAS No. 1245319-54-3. Molecular formula: C22H22N8OS. Mole weight: 446.53.
PI5P4Kα-IN-1 (Compound 13) is a PI5P4K inhibitor ( IC 50 : 2 and 9.4 μM for PI5P4Kα and PI5P4Kβ). PI5P4Kα-IN-1 can be used for research of cancer, metabolic and immunological disorders [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2428737-31-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153531.
PI5P4Kγ-IN-1
PI5P4Kγ-IN-1 (compound 2) is a selective PI5P4Kγ inhibitor. PI5P4Kγ-IN-1 can be used to signal mTORC1 in MCF-7 breast cancer cells and further characterize PI5P4Kγ in the cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2419358-87-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153789.
PI 828
PI 828 is a cell permeable 4'-amino derivative which inhibits the p110α, p110β, p110δ, and p110γ subunits of PI 3-kinase. PI-828 is a potent inhibitor of phosphatidylinositol 3-kinase (PI3K; IC50s = 9.8, 183, 227, and 1,967 nM for p110β, p110α, p110δ, and p110γ, respectively) that displays higher potency than LY 294002. Synonyms: LY294002,4'-NH2; PI-828; PI 828; PI828. 2-(4-Morpholinyl)-8-(4-aminopheny)l-4H-1-benzopyran-4-one. Grades: ≥99% by HPLC. CAS No. 942289-87-4. Molecular formula: C19H18N2O3. Mole weight: 322.36.
PI 828
PI 828. Group: Biochemicals. Grades: Purified. CAS No. 942289-87-4. Pack Sizes: 1mg, 10mg, 50mg. US Biological Life Sciences.
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PIAnCN
PIAnCN. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 4-(10-(4-(1-Phenyl-1H-phenanthro[9,10-d]imidazol-2-yl)phenyl) anthracen-9-yl)benzonitrile. Product Category: Organic Light Emitting Diode (OLED). CAS No. 2186679-41-2. Molecular formula: C48H29N3. Mole weight: 647.76 g/mol. Product ID: ACM2186679412. Alfa Chemistry ISO 9001:2015 Certified. Categories: Piano.
PIANO n-Paraffins Mixture 99
PIANO n-Paraffins Mixture 99. Uses: For analytical and research use. Group: Hydrocarbons & petrochemicals. Catalog: APS011260. Format: Mixture. Shipping: Room Temperature.
PiB
PiB. Uses: Designed for use in research and industrial production. Additional or Alternative Names: IN1141; diethyl 1,3,6,8-tetrahydro-1,3,6,8-tetraoxobenzo[lmn][3,8]phenanthroline-2,7-diacetate; phenanthroline-(2H,7H)-diacetate; (1,3,6,8-Tetraoxo-1,3,6,8-tetrahydro-benzo[lmn][3,8]phenanthrolin-2,7-diyl)-di-essigsaeure-diaethylester; (1,3,6,8-tetraoxo-1. Product Category: Heterocyclic Organic Compound. CAS No. 64005-90-9. Molecular formula: C22H18N2O8. Mole weight: 438.39. Purity: 0.96. IUPACName: PPIase-Parvulin Inhibitor. Canonical SMILES: CCOC(=O)CN1C(=O)C2=C3C(=CC=C4C3=C(C=C2)C(=O)N(C4=O)CC(=O)OCC)C1=O. Density: 1.471g/cm³. Product ID: ACM64005909. Alfa Chemistry ISO 9001:2015 Certified.
Piboserod is a highly and potent selective 5-HT4 receptor antagonist which as been studied in vitro as well as in vivo as a pharmacological tool to evaluate the pathophysiological role of the 5-HT4 receptor in human gastrointestinal pathophysiology. Synonyms: N-[(1-butylpiperidin-4-yl)methyl]-3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxamide Piboserod UNII-4UQ3S81B25 SB-207266 152811-62-6 SB207256 SB 207266 N-[(1-butylpiperidin-4-yl)methyl]-3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxamide Pibosero. Grades: 95%. CAS No. 152811-62-6. Molecular formula: C22H31N3O2. Mole weight: 369.51.
Piboserod
Piboserod (SB 207266) is a 5-HT4 selective inhibitor of the serotonin receptor. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SB-207266. CAS No. 152811-62-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15574.
Piboserod hydrochloride
Piboserod hydrochloride is a selective 5-HT4 antagonist. Synonyms: Piboserod HCl; N-[(1-butylpiperidin-4-yl)methyl]-3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxamide hydrochloride. Grades: 99%. CAS No. 178273-87-5. Molecular formula: C22H31N3O2.HCl. Mole weight: 405.96.
Pibrentasvir
Pibrentasvir is a novel and pan-genotypic hepatitis C virus ( HCV ) NS5A inhibitor with EC 50 s ranging from 1.4 to 5.0 pM against HCV replicons containing NS5A from genotypes 1 to 6. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ABT-530. CAS No. 1353900-92-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101662.
Pibrentasvir
Pibrentasvir is an antiviral agent that inhibits HCV non-structural protein 5A (NS5A). It inhibits HCV RNA replication and viron assembly. In combination with glecaprevir, a HCV NS3/4A protease inhibitor, pibrentasvir is used to treat patients with HCV infections who experienced therapeutic failure from other NS5A inhibitors. Grades: ≥98%. CAS No. 1353900-92-1. Molecular formula: C57H65F5N10O8. Mole weight: 1113.18.
Picamilon
Picamilon is an orally active derivative of γ-aminobutyric acid that has nootropic effect. Picamilon improves the epilepsy model in rats and promotes correction of functional disorders of the pancreas during Alloxan (HY-W017227)-induced diabetes mellitus in rats [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Nicotinoyl-GABA; Nicotinoyl-γ-aminobutyric acid. CAS No. 34562-97-5. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g. Product ID: HY-107482.
Picankibart is a mouse-derived IgG1κ antibody targeting IL23A [1]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 2622900-74-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990057.
Picaridin
Picaridin (Lcaridin) is a broad spectrum arthropod repellent. The repellent and deterrent activities of Picaridin involve olfactory sensing in mosquitoes, and ticks, via their interactions with odorant receptor proteins. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: Liquid. CAS No. 119515-38-7. Molecular formula: C12H23NO3. Mole weight: 229.32. Purity: ≥93%. Canonical SMILES: O=C(N1C(CCCC1)CCO)OC(CC)C. Product ID: ACM119515387-3. Alfa Chemistry ISO 9001:2015 Certified.
Picaridin
Picaridin,also known as Icaridin, KBR 3023, under the INCI name hydroxyethyl isobutyl piperidine carboxylate, and the trade names Bayrepel and Saltidin, is an insect repellent that is effective against a range of arthropods, including mosquitoes and ticks. Uses: Acts on certain olfactory receptor cell types to reduce the activating or attracting effect of odor sources; insect repellent. Synonyms: KBR 3023; KBR-3023; KBR3023. ICARIDIN;1-(1-methyl-propoxycarbonyl)-2-(2-hydroxyethyl)-piperidine;1-(1-methylpropoxycarbonyl)-2-(2-hydroxyethyl)piperidine;1-methylpropyl2-(2-hydroxyethyl)-1-piperidinecarboxylate;2-(2-hydroxyethyl)-1-piperidinecarboxylicaci1-methylpropylester. Grades: 98%. CAS No. 119515-38-7. Molecular formula: C12H23NO3. Mole weight: 229.32.
Picaridin
Acts on certain olfactory receptor cell types to reduce the activating or attracting effect of odor sources. Insect repellent. Picaridin is an insect repellent that is effective against a range of arthropods, including mosquitoes and ticks.1,2 It shows synergy with the non-pyrethroid insecticide propoxur both in killing and repelling mosquitoes.3 Picaridin and other insect repellents have been shown to act as either agonists or antagonists at insect olfactory receptors.4,5. Group: Biochemicals. Alternative Names: 2-(2-Hydroxyethyl)-1-piperidinecarboxylic Acid 1-Methyl-propyl Ester; Icaridin; KBR 3023; Bayrepel. Grades: Highly Purified. CAS No. 119515-38-7. Pack Sizes: 100g, 250g, 500g. US Biological Life Sciences.
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Picaridin
Picaridin (Lcaridin) is a broad spectrum arthropod repellent. Picaridin interacts with mosquito and tick olfactory receptor proteins. Picaridin repels Aedes aegypti. Picaridin exhibits considerable antibacterial , anticandidal and antifungal properties [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Lcaridin. CAS No. 119515-38-7. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-116144.
Picaridin-d3
Acts on certain olfactory receptor cell types to reduce the activating or attracting effect of odor sources. Group: Biochemicals. Alternative Names: 2-(2-Hydroxyethyl)-1-piperidinecarboxylic Acid 1-Methyl-d3-propyl Ester; Icaridin-d3; KBR 3023-d3; Bayrepel-d3. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
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Piceain 1
Piceain 1 is an antimicrobial peptide found in Picea sitchensis, and has activity against E.coli, P.aerμginosa, S.aureus and fungus C.albicans. It shows weak hemolysis activity. Synonyms: H-Lys-Ser-Leu-Arg-Pro-Arg-Cys-Trp-Ile-Lys-Ile-Lys-Phe-Arg-Cys-Lys-Ser-Leu-Lys-Phe-OH; L-lysyl-L-seryl-L-leucyl-L-arginyl-L-prolyl-L-arginyl-L-cysteinyl-L-tryptophyl-L-isoleucyl-L-lysyl-L-isoleucyl-L-lysyl-L-phenylalanyl-L-arginyl-L-cysteinyl-L-lysyl-L-seryl-L-leucyl-L-lysyl-L-phenylalanine. Grades: ≥96%. Molecular formula: C118H197N35O23S2. Mole weight: 2538.18.
Piceain 2
Piceain 2 is an antimicrobial peptide found in Picea sitchensis, and has activity against E.coli, P.aeruginosa, S.aureus and fungus C.albicans. It shows weak hemolysis activity. Synonyms: H-Arg-Pro-Arg-Cys-Trp-Ile-Lys-Ile-Lys-Phe-Arg-Cys-Lys-Ser-Leu-Lys-Phe-OH; L-arginyl-L-prolyl-L-arginyl-L-cysteinyl-L-tryptophyl-L-isoleucyl-L-lysyl-L-isoleucyl-L-lysyl-L-phenylalanyl-L-arginyl-L-cysteinyl-L-lysyl-L-seryl-L-leucyl-L-lysyl-L-phenylalanine. Grades: ≥95%. Molecular formula: C103H169N31O19S2. Mole weight: 2209.77.
Piceatannol
Wide range of tyrosine and serine/threonine protein kinase inhibitor, including Syk, p56lck, PKA, PKC, MLCK, CDPK, JNK and PI3K. Inhibits the tyrosine phosphorylation of STAT3 and STAT5. Potent apoptosis inducer. Potent anticancer compound. Suppresses NF-kB activation through IkBalpha kinase inhibition. Activator of human deacetylase SIRT1 (sirtuin 1). Potent antioxidant with anti-proliferative, anti-inflammatory and cardioprotective properties. Neuoprotective. Adipogenesis inhibitor. Promotes glucose uptake, AMPK phosphorylation and GLUT4 translocation. Group: Biochemicals. Grades: Highly Purified. CAS No. 10083-24-6. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C??H??O?. US Biological Life Sciences.
Piceatannol is a well-known Syk inhibitor and reduces the expression of iNOS induced by TNF. Piceatannol is an effective agent for research of acute lung injury (ALI) [1]. Piceatannol is a naturally occurring polyphenolic stilbene found in various fruits and vegetables and exhibits anticancer and anti-inflammatory properties [2]. Piceatannol induces apoptosis in DLBCL cell lines [3]. Piceatannol induces autophagy and apoptosis in MOLT-4 human leukemia cells [4]. Uses: Scientific research. Group: Natural products. Alternative Names: Astringenin; trans-Piceatannol. CAS No. 10083-24-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13518.
Piceatannol 3'-O-glucoside
Piceatannol 3'-O-glucoside. Group: Biochemicals. CAS No. 94356-26-0. Pack Sizes: 5mg. US Biological Life Sciences.
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Piceatannol, (E)-
Piceatannol, (E)-. Group: Biochemicals. CAS No. 10083-24-6. Pack Sizes: 5mg. US Biological Life Sciences.
A naturally occurring resveratrol analog. Inhibits nonreceptor kinases Syk and Lyk (IC50=ca. 10M)1. Stimulates Sirt12. Group: Biochemicals. Alternative Names: SIRT1 Activator,3,3?,4,5?-Tetrahydroxy-transstilbene. Grades: Highly Purified. CAS No. 10083-24-6. Pack Sizes: 5mg, 25mg. US Biological Life Sciences.
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Piceatannol (trans-Picetannol, Astringenin)
Cell-permeable. Kartogenin promotes the differentiation of multipotent mesenchymal stem cells into chondrocytes (EC50 = 100nM). Displays chondroprotective effects in vitro and is efficacious in two animal models of osteoarthritis. Group: Biochemicals. Alternative Names: trans-3,3',4,5'-Tetrahydroxystilbene. Grades: Highly Purified. CAS No. 10083-24-6. Pack Sizes: 5mg, 25mg. US Biological Life Sciences.
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Picein
Picein, isolated from Picrorhiza kurroa , is a naturally occurring antioxidant [1]. Uses: Scientific research. Group: Natural products. CAS No. 530-14-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N8698.
Picfeltarraenin IA is a naturally occurring triterpenoid glycoside that acts as an AChE inhibitior. It also inhibits PI3K and EGFR. CAS No. 97230-47-2. Molecular formula: C41H62O13. Mole weight: 762.92.
Picfeltarraenin IA
Botanical Source: Group: Biochemicals. Grades: Plant Grade. CAS No. 97230-47-2. Pack Sizes: 10mg. US Biological Life Sciences.
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Picfeltarraenin IB
Picfeltarraenin IB is a triterpenoid Picria isolated from felterrae Lour. Synonyms: HY-N2211. Grades: 98%. CAS No. 97230-46-1. Molecular formula: C42H64O14. Mole weight: 792.95.
Picfeltarraenin IB
Picfeltarraenin IB. Group: Biochemicals. Grades: Plant Grade. CAS No. 97230-46-1. Pack Sizes: 5mg. Molecular Formula: C42H64O14, Molecular Weight: 792.96. US Biological Life Sciences.
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Picfeltarraenin IV
Picfeltarraenin IV. Group: Biochemicals. Grades: Plant Grade. CAS No. 184288-35-5. Pack Sizes: 5mg. Molecular Formula: C47H72O18, Molecular Weight: 925.08. US Biological Life Sciences.
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Picfeltarraenin X
Picfeltarraenin X. Group: Biochemicals. Grades: Plant Grade. CAS No. 1391826-61-1. Pack Sizes: 5mg. Molecular Formula: C36H54O11, Molecular Weight: 662.82. US Biological Life Sciences.
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Picfeltarraenin X
Picfeltarraenin X is a triterpenoid compound isolated from the herbs of Picria felterrae Lour. Picfeltarraenin X exhibits inhibitory effect against AChE. Synonyms: (2beta,3alpha,9beta,10alpha,16alpha)-2-(beta-D-Glucopyranosyloxy)-20,24-epoxy-3,16-dihydroxy-9-methyl-19-norlanosta-5,23-diene-11,22-dione. Grades: >98%. CAS No. 1391826-61-1. Molecular formula: C36H54O11. Mole weight: 662.817.
A cell-permeable acryloylcarbamate compound that selectively targets the PDZ (PSD-95/Discs-large/ZO-1 homology) domain of PICK1 (protein interacting with C kinase 1), but not those of PSD-95 (postsynaptic density protein 95) and GRIP1 (glutamate receptor interacting protein 1), effectively competing against dopamine transporter/DAT (Ki ~10uM), GluR2 (Ki ~10uM), and mRluR7a, c-terminus binding to PICK1 PDZ. Shown to accelerate internalized GluR2 surface recycling and suppress both long-term depression and potentiation in rat and murine hippocampal neurons. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Piclamilast (RP 73401) is a phosphodiesterase 4 (PDE4) inhibitor, with IC 50 values of 16 nM and 2 nM in pig aorta and eosinophil soluble, respectively [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RP 73401; RPR 73401. CAS No. 144035-83-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-12887.
Piclamilast
Piclamilast is a potent and selective phosphodiesterase-4 (PDE4) inhibitor. Piclamilast may offer therapeutic strategies in respiratory diseases, including asthma and chronic obstructive pulmonary disease. Piclamilast may also provide a treatment option for pre-term infants with bronchopulmonary dysplasia (BPD). Group: Biochemicals. Alternative Names: 3-(Cyclopentyloxy)-N-(3,5-dichloro-4-pyridinyl)-4-methoxybenzamide; N-(3,5-Dichloropyrid-4-yl)-3-cyclopentyloxy-4-methoxybenzamide; RP 73401; RPR 73401. Grades: Highly Purified. CAS No. 144035-83-6. Pack Sizes: 10mg. US Biological Life Sciences.
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Piclamilast
Piclamilast is a potent and selective phosphodiesterase-4 (PDE4) inhibitor (IC50 = 1 nM at PDE4 from human neutrophils) with >19,000-fold selectivity over other PDE isoenzymes. Uses: Phosphodiesterase 4 inhibitors. Synonyms: Piclamilast; RP-73401; RP 73-401; RP 73401; RP 73 401; RP73401; RP 73401; 3-(Cyclopentyloxy)-N-(3,5-dichloro-4-pyridinyl)-4-methoxybenzamide; N-(3,5-Dichloropyrid-4-yl)-3-cyclopentyloxy-4-methoxybenzamide. Grades: ≥99% by HPLC. CAS No. 144035-83-6. Molecular formula: C18H18Cl2N2O3. Mole weight: 381.25.