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| Product | Description | |
|---|---|---|
| s-Fexofenadine | s-Fexofenadine. Uses: Designed for use in research and industrial production. Additional or Alternative Names: S-FEXOFENADINE;S-Carboxyterfenadine,S-Terfenadinecarboxylate;Benzeneacetic acid, 4-[(1S)-1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-α,α-dimethyl-;Benzeneacetic acid, 4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-α,α-dime. Product Category: Heterocyclic Organic Compound. Appearance: White Solid. CAS No. 139965-11-0. Molecular formula: C32H39NO4. Mole weight: 501.663. Product ID: ACM139965110. Alfa Chemistry ISO 9001:2015 Certified. Categories: (S)-Fexofenadine. |  |
| S-Fexofenadine (S-Carboxyterfenadine, S-Terfenadinecarboxyl ate) | A metabolite of of terfenadine, a H1-Histamine receptor antagonist. Group: Biochemicals. Alternative Names: S-Carboxyterfenadine, S-Terfenadinecarboxyl ate. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| SFI003 | SFI003 is a SRSF3 inhibitor that drives CRC cell apoptosis via the SRSF3/DHCR24/ROS axis and exhibits potent antitumor effects both in vitro and in vivo[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2361332-90-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148660. |  |
| Sfi I | One unit of the enzyme is the amount required to hydrolyze 1 μg of T7 DNA in 1 hour at 50°C in a total reaction volume of 50 μl. Applications: After 10-fold overdigestion with enzyme more than 70% of the dna fragments can be ligated and recut. in the presence of 10% peg ligation is better. Group: Restriction Enzymes. Purity: 1000U; 5000U. GGCCNNNN↑NGGCC CCGGN↓NNNNCCGG. Activity: 10000u.a./ml. Appearance: 10 X SE-buffer G, BSA. Storage: -20°C. Form: Liquid. Source: An E.coli strain, that carries the cloned gene Sfi I from Streptomyces fimbriatus. Pack: 10 mM Tris-HCl (pH 7.5); 200 mM NaCl; 0.1 mM EDTA; 7 mM 2-mercaptoethanol; 200 μg/ml BSA; 50% glycerol. Cat No: ET-1173RE. |  |
| SFK1 | ?98% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. |  |
| s-(+)-Flecainide | s-(+)-Flecainide. Uses: Designed for use in research and industrial production. Additional or Alternative Names: N-[(2S)-2-Piperidinylmethyl]-2,5-bis(2,2,2-trifluoroethoxy)benzamide. Product Category: Heterocyclic Organic Compound. CAS No. 99495-92-8. Molecular formula: C17H20F6N2O. Mole weight: 414.34. Product ID: ACM99495928. Alfa Chemistry ISO 9001:2015 Certified. | |
| S-(+)-Flecainide | A stereoisomer of Flecainide. Flecainide is a class 1C antiarrhythmic drug especially used for the management of supraventricular arrhythmia. Synonyms: N-[(2S)-2-Piperidinylmethyl]-2,5-bis(2,2,2-trifluoroethoxy)benzamide; (S)-Flecainide; (+)-Flecainide. Grades: > 95%. CAS No. 99495-92-8. Molecular formula: C17H20F6N2O3. Mole weight: 414.35. |  |
| S-(+)-Flecainide | S-(+)-Flecainide. Group: Biochemicals. Alternative Names: N-[ (2S) -2-Piperidinylmethyl]-2, 5-bis (2, 2, 2-trifluoroethoxy) benzamide. Grades: Highly Purified. CAS No. 99495-92-8. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C17H20F6N2O3. US Biological Life Sciences. | Worldwide |
| Sfllrnpndkyepf | Cas No. 137339-65-2. | |
| S-Flurbiprofen-acyl-β-D-glucuronide | S-Flurbiprofen-acyl-β-D-glucuronide is an indispensably vital compound in the biomedical industry, exhibiting as an active metabolite of flurbiprofen. This extraordinary product assumes a pivotal role in the vast realm of studying diverse inflammatory ailments and efficaciously managing pain. Grades: > 95%. CAS No. 162992-66-7. Molecular formula: C21H21FO8. Mole weight: 420.39. | |
| S-formylglutathione hydrolase | Also hydrolyses S-acetylglutathione, but more slowly. Group: Enzymes. Enzyme Commission Number: EC 3.1.2.12. CAS No. 83380-83-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3547; S-formylglutathione hydrolase; EC 3.1.2.12; 83380-83-0. Cat No: EXWM-3547. | |
| SF-PDI | Band gap: 2.1 eV. Group: Organic field effect transistor (ofet) materials organic solar cell (opv) materials. Alternative Names: 1-(3-Butoxycarbonylpropyl)-1-phenyl-[6.6]C61. CAS No. 1643842-69-6. Pack Sizes: 100 mg in glass bottle. Molecular formula: 1822.44. Mole weight: C125H136N4O8. O=C1N (C (CCCCCC) CCCCCC) C (C2=C (C1=CC=C3C4=C (C (C=C5) =CC6=C5C (C=CC (C7=CC8=C9C% 10=C7C% 11=C% 12C (C% 13=CC=C% 12C% 10=CC=C9C (N (C (CCCCCC) CCCCCC) C8=O) =O) =C (C (N (C (CCCCCC) CCCCCC) C% 13=O) =O) C=C% 11) =C% 14) =C% 14C6% 15C% 16=CC=CC=C% 16C% 17=C% 15C=CC=C% 17) C=C (C (N (C (CCCCCC) CCCCCC) C. InChI=1S / C125H136N4O8 / c1-9-17-25-33-45-79 (46-34-26-18-10-2) 126-117 (130) 93-67-61-87-89-63-69-97-113-101 (123 (136) 128 (121 (97) 134) 81 (49-37-29-21-13-5) 50-38-30-22-14-6) 75-99 (109 (115 (89) 113) 91-65-71-95 (119 (126) 132) 111 (93) 107 (87) 91) 77-57-59-85-86-60-58-78 (74-106 (86) 125 (105 (85) 73-77) 103-55-43-41-53-83 (103) 84-54-42-44-56-104 (84) 125) 100-76-102-114-98 (122 (135) 129 (124 (102) 137) 82 (51-39-31-23-15-7) 52-40-32-24-16-8) 70-64-90-88-62-68-94-112-96 (72-66-92 (108 (88) 112) 110 (100) 116 (90) 114) 120 (133) 127 (118 (94) 131) 80 (47-35-27-19-11-3) 48-36-28-20-12-4 / h41-44, 53-76, 79-82H, 9-40, 45-52H2, 1-8H3. FYQVTINZMWVMSE-UHFFFAOYSA-N. |  |
| Sfr274 I | One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA (Hind III-digest) in 1 hour at 50°C in a total reaction volume of 50 μl. Applications: After 20-fold overdigestion with enzyme 90% of the dna fragments can be ligated and recut. Group: Restriction Enzymes. Purity: 2000U; 10000U. C↑TCGAG GAGCT↓C. Activity: 20000u.a./ml. Appearance: 10 X SE-buffer B. Storage: -20°C. Form: Liquid. Source: Streptomyces fradiae 274. Pack: 10 mM Tris-HCl (pH 7.5); 50 mM KCl; 0.1 mM EDTA; 7 mM 2-mercaptoethanol; 200 μg/ml BSA; 50% glycerol. Cat No: ET-1174RE. | |
| Sfr303 I | One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 10-fold overdigestion with enzyme more than 90% of the dna fragments can be ligated and recut. Group: Restriction Enzymes. Purity: 1000U; 5000U. CCGC↑GG GG↓CGCC. Activity: 10000u.a./ml. Appearance: 10 X SE-buffer B. Storage: -20°C. Form: Liquid. Source: Streptomyces fradiae 303. Pack: 10 mM Tris-HCl (pH 7.5); 100 mM NaCl; 0.1 mM EDTA; 7 mM 2-mercaptoethanol; 200 μg/ml BSA; 50% glycerol. Cat No: ET-1175RE. | |
| sFRP-1 human | recombinant, expressed in HeLa cells, ?97% (SDS-PAGE), ?97% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| sFRP-1 Inhibitor - CAS 915754-88-0 | The sFRP-1 Inhibitor, also referenced under CAS 915754-88-0, controls the biological activity of sFRP-1. This small molecule/inhibitor is primarily used for Activators/Inducers applications. Group: Fluorescence/luminescence spectroscopy. | |
| SFTI-1 | SFTI-1 is a cyclic peptide trypsin inhibitor consisting of 14 amino acid residues. SFTI-1 belongs to the Bowman-Birk class of inhibitors. Characterized by its small size, high stability, and potent activity, SFTI-1 can be used for research on peptide drug design platforms[1][2]. Uses: Scientific research. Group: Peptides. CAS No. 245080-24-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P10033. | |
| SFXSPO | SFXSPO. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Diphenylspiro[9H-fluorene-9,9'-[9H]xanthen]-4'-ylphosphine oxide. Product Category: Organic Light Emitting Diode (OLED). CAS No. 1508022-28-3. Molecular formula: C37H25O2P. Mole weight: 532.57 g/mol. Product ID: ACM1508022283. Alfa Chemistry ISO 9001:2015 Certified. Categories: SFX (software). | |
| SG-094 | SG-094 is a potent TPC2 inhibitor with antiproliferative effects. SG-094 can be used for the research of cancer[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2922283-37-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148816. | |
| SG-209 | solid, ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| SG3199 | SG3199 is a cytotoxic DNA minor groove interstrand crosslinking pyrrolobenzodiazepine (PBD) dimer. SG3199 is the released warhead component of the ADC payload Tesirine (SG3249)[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1595275-71-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-101161. | |
| SGA360 | SGA360. Group: Biochemicals. Alternative Names: 3-(2,4-Dimethoxyphenyl)-1-(2-propen-1-yl)-7-(trifluoromethyl)-1H-indazole; 1-Allyl-3-(2,4-dimethoxyphenyl)-7-(trifluoromethyl)-1H-indazole. Grades: Highly Purified. CAS No. 680611-86-3. Pack Sizes: 10mg. Molecular Formula: C19H17F3N2O2, Molecular Weight: 362.35. US Biological Life Sciences. | Worldwide |
| SGA360 | SGA360 is a selective modulator of the aryl hydrocarbon receptor (AhR) that competitively binds to AhR (IC50 = 3 μM) and represses serum amyloid A 1 (SAA1) gene expression induced by IL-1β in Huh7 cells. It also exhibits anti-inflammatory activity. Synonyms: 3-(2,4-dimethoxyphenyl)-1-prop-2-enyl-7-(trifluoromethyl)indazole. Grades: ≥98%. CAS No. 680611-86-3. Molecular formula: C19H17F3N2O2. Mole weight: 362.4. | |
| SGA360-d5 | SGA360-d5. Group: Biochemicals. Alternative Names: 3-(2,4-Dimethoxyphenyl)-1-(2-propen-1-yl)-7-(trifluoromethyl)-1H-indazol-d5; 1-Allyl-3-(2,4-dimethoxyphenyl)-7-(trifluoromethyl)-1H-indazole-d5. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C19H12D5F3N2O2, Molecular Weight: 367.38. US Biological Life Sciences. | Worldwide |
| SGC0946 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| SGC0946 | SGC0946 Inhibitor. Uses: Scientific use. Product Category: T3082. CAS No. 1561178-17-3. |  |
| SGC0946 | SGC0946 is a selective DOT1L H3K79 methyltransferase ) inhibitor, with an IC 50 of 0.3 nM. SGC0946 results in G1 arrest, inhibits potential of cell self-renewal and metastatic, also induces cell differentiation. SGC0946 can be used in studies of leukemia and solid tumors and also serve as a probe to further investigate the cellular mechanism of DOT1L in both normal and diseased cells [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1561178-17-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-15650. | |
| SGC 0946 | SGC0946 is a potent and selective inhibitor of DOT1L, which potently and selectively kills cells containing an MLL translocation. SGC0946 inhibits DOT1L with an IC50 of 0.3nM in a radioactive enzyme assay and is over 100-fold selective for other HMTs. Synonyms: SGC-0946; SGC 0946; SGC0946. Grades: >98%. CAS No. 1561178-17-3. Molecular formula: C28H40BrN7O4. Mole weight: 618.57. | |
| SGC-0946 | SGC-0946. Group: Biochemicals. Alternative Names: 1- (3- ( ( ( (2R, 3S, 4R, 5R) -5- (4-Amino-5-bromo-7H-pyrrolo [2, 3-d] pyrimidin-7-yl) -3, 4-di hydroxytetra hydrofuran-2-yl) methyl ) (isopropyl ) amino) propyl ) -3- (4- (tert-butyl) phenyl) urea. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C28H40BrN7O4, Molecular Weight: 618.57. US Biological Life Sciences. | Worldwide |
| SGC 0946 (1- [3- [ [ [ (2R, 3S, 4R, 5R) -5- (4-Amino-5-bromo-7H-pyrrolo [2, 3-d] pyrimidin-7-yl) -3, 4-di hydroxytetra hydrofuran-2-yl] methyl ] (isopropyl ) amino] propyl] -3- [4- (2, 2-di methyl ethyl) phenyl] urea) | Potent DOT1L methyltransferase inhibitor (KD = 0.06nm, IC50 = 0.3nm in a radioactive assay); blocks H3K79 methylation in A431 cells and MCF10A cells (IC50 values are 2.65 and 8.8nm respectively). Inactive at 12 histone methyltransferases and DNMT1. Selectively kills cells transformed with the MLL-AF9 fusion oncogene in an in vitro model of leukemia; lowers levels of MLL target genes HOXA9 and Meis1. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| SGC2085 | SGC2085, also called as GTPL9259, is a potent and selective Coactivator Associated Arginine Methyltransferase 1 (CARM1), which has an IC50 of 50 nM for CARM1 and is over 100-fold selective for CARM1 over PRMT6. Synonyms: SGC2085; SGC-2085; SGC 2085. Grades: 99.05 %. CAS No. 1821908-48-8. Molecular formula: C19H24N2O2. Mole weight: 312.41. | |
| SGC2085 | SGC2085 is a potent and selective inhibitor of coactivator associated arginine methyltransferase 1 ( CARM1 ) with an IC 50 of 50 nM. SGC2085 also selectively inhibits PRMT6 with an IC 50 value of 5.2 μM, but not other PRMT proteins [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1821908-48-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100565. | |
| SGC2085 HCl | SGC2085, also called as GTPL9259, is a potent and selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor with an IC50 of 50 nM and more than undred-fold selectivity over other PRMTs. Synonyms: SGC2085 HCl; SGC 2085 HCl; SGC-2085 HCl; (2S)-2-amino-N-[[4-(3, 5-dimethylphenoxy)-3-methylphenyl]methyl]propanamide; hydrochloride; 1821908-48-8 (SGC2085 free base). Grades: >98%. CAS No. 1821908-49-9. Molecular formula: C19H25ClN2O2. Mole weight: 348.87. | |
| SGC3027 | SGC3027 is a histone methyltransferase inhibitor[1]. SGC3027 is the first potent, selective and cell active chemical probe for PRMT7[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2624313-13-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112445. | |
| SGC707 | SGC707 is a potent, selective, and non-competitive PRMT3 (protein arginine methyltransferase 3) inhibitor (IC50=31 nM, Kd=53 nM). Uses: Scientific research. Group: Signaling pathways. CAS No. 1687736-54-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-19715. | |
| SGC707 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| SGC707 | SGC707 is a potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase?3 (PRMT3) with IC50 and Kd of 31 nM and 53 nM, respectively. Synonyms: SGC-707; SGC 707. Grades: 98%. CAS No. 1687736-54-4. Molecular formula: C16H18N4O2. Mole weight: 298.34. | |
| SGC AAK1 1 | SGC AAK1 1 is a potent and selective inhibitor of adaptor-associated protein kinase 1 (AAK1) and BMP-2-inducible protein kinase (BMP2K) inhibitor. It activates Wnt signaling. Synonyms: AAK1 inhibitor 1; N-(6-(3-((N,N-diethylsulfamoyl)amino)phenyl)-1H-indazol-3-yl)cyclopropanecarboxamide. Grades: ≥98% by HPLC. CAS No. 2247894-32-0. Molecular formula: C21H25N5O3S. Mole weight: 427.52. | |
| SGC-AAK1-1 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| SGC-AAK1-1 | SGC-AAK1-1 is a potent and selective AAK1 (AP2 associated kinase 1) inhibitor with an IC 50 of 270 nM and a K i of 9 nM. SGC-AAK1-1 also potently inhibits BMP2K. SGC-AAK1-1 is used to study Wnt pathway related to AAK1 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2247894-32-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123940. | |
| SGC-AAK1-1N | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| SGC-CBP30 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| SGC-CBP30 | SGC-CBP30 is a potent and selective inhibitor of CREBBP (CBP) and EP300; which are general transcriptional co-activators. Mutations of CREBBP and EP300 lead to Rubinstein-Taybi syndrome (RTS), characterised by growth retardation, facial abnormalities, organ abnormalities, mental retardation and altered tumor susceptibility. Synonyms: SGCCBP30; SGC CBP30. Grades: 0.98. CAS No. 1613695-14-9. Molecular formula: C28H33ClN4O3. Mole weight: 509.03962. | |
| SGC-CBP30 | SGC-CBP30 is a potent and highly selective CBP/p300 bromodomain (Kds of 21 nM and 32 nM for CBP and p300, respectively) inhibitor, displaying 40-fold selectivity over the first bromodomain of BRD4 [BRD4(1)] bound. SGC-CBP30 strongly reduces secretion of IL-17A in Th17 cells and has anti-inflammatory effects[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1613695-14-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15826. | |
| SGC-CK2-1 | SGC-CK2-1 is a highly potent, ATP-competitive, and cell-active CK2 chemical probe with exclusive selectivity for both human CK2 isoforms, with IC 50 s of 36 and 16 nM for CK2α and CK2αrespectively in the nanoBRET assay. SGC-CK2-1 can be used for the research of neurodegenerative diseases [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2470424-39-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139004. | |
| SGC GAK 1 | SGC GAK 1 is a high affinity cyclin G associated kinase (GAK) inhibitor with >30-fold selectivity for GAK over a panel of other kinases. Synonyms: SGC-GAK-1; BCP30478; 6-Bromo-N-(3,4,5-trimethoxyphenyl)-4-quinolinamine. Grades: ≥99% by HPLC. CAS No. 2226517-76-4. Molecular formula: C18H17BrN2O3. Mole weight: 389.24. | |
| SGC-GAK-1 | SGC-GAK-1 is a potent, selective cyclin G-associated kinase (GAK) inhibitor with a Ki of 3.1 nM. SGC-GAK-1 is a chemical probe for GAK[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2226517-76-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122186. | |
| SGC-GAK-1 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| SGC-GAK-1N | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| SGC-STK17B-1 | SGC-STK17B-1 is an ATP-competitive and selective STK17B (a member of DAPK family) inhibitor ( IC 50 : 34 nM, K D : 5.6 nM) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2650530-00-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-156350. | |
| SGD-1882 | SGD-1882 is a cytotoxic, DNA minor-groove crosslinking agent pyrrolobenzodiazepine (PBD) dimer, acting as the payload for ADCs. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PBD dimer. CAS No. 1222490-34-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-101127. | |
| SGD-1910 | SGD-1910 is a agent-linker conjugate for ADC by using the antitumor antibiotic, pyrrolobenzodiazepine (PBD, a cytotoxic DNA crosslinking), linked via the cleavable linker MC-Val-Ala[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1342820-51-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-101162. | |
| SGF29-IN-1 | SGF29-IN-1 (Compound Cpd_DC60) is a selective inhibitor for Spt-Ada-Gcn5 acetyltransferase (SAGA)-associated factor 29 (SGF29)-Tudor domain. SGF29-IN-1 exhibits activity against leukemia[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 6638-82-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-158009. | |
| SGI 1027 | SGI 1027. Group: Biochemicals. Grades: Purified. CAS No. 1020149-73-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SGI-1027 | SGI-1027 is a potent DNMT inhibitor, which reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degradation. Treatment of different cancer cell lines with SGI-1027 resulted in selective degradation of DNMT1 with minimal or no effects on DNMT3A and DNMT3B. SGI-1027 may have the potential for use in epigenetic cancer therapy. Synonyms: SGI 1027; SGI1027. Grades: 0.98. CAS No. 1020149-73-8. Molecular formula: C27H23N7O. Mole weight: 461.529. | |
| SGI-1027 | SGI-1027 is a DNA methyltransferase (DNMT) inhibitor, with IC50s of 7.5 ?M, 8 ?M, and 12.5 ?M for DNMT3B, DNMT3A, and DNMT1 with poly(dI-dC) as substrate. Uses: Scientific research. Group: Signaling pathways. CAS No. 1020149-73-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-13962. | |
| SGI-1027 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| SGI 1027 dihydrochloride | SGI 1027 is a DNA methyltransferase (DNMT) inhibitor (IC50 values 35 μM and 10 μM for DNMT1 and DNMT3A2/3L, respectively). It was shown to degrade the enzymes and reactivate the silenced tumor suppressor genes (TSGs) P16, MLH1, and TIMP3 devoid of significant toxicity in a rat hepatoma (H4IIE) cell line. Synonyms: SGI 1027 dihydrochloride; SGI1027 dihydrochloride; SGI-1027 dihydrochloride; N-[4-[(2-Amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)benzamide dihydrochloride. Grades: 99%. CAS No. 2108487-01-8. Molecular formula: C27H25Cl2N7O. Mole weight: 534.44. | |
| SGI-110 | SGI-110 is a dinucleotide antimetabolite of a decitabine linked via phosphodiester bond to a guanosine, with potential antineoplastic activity. Following metabolic activation by phosphorylation and incorporation into DNA, SGI-110 inhibits DNA methyltransferase, thereby causing genome-wide and non-specific hypomethylation and inducing cell cycle arrest at S-phase. This agent is resistant to cytidine deaminase, hence may result in gradual release of decitabine both extra- and intracellularly, leading to more prolonged exposures to decitabine. Uses: Antineoplastic agents. Synonyms: Guadecitabine; SGI 110; SGI110; 2'-deoxy-5-azacytidylyl-(3'->5')-2'-deoxyguanosine; (2R,3S,5R)-5-(4-amino-2-oxo-1,3,5-triazin-1(2H)-yl)-2-(hydroxymethyl)tetrahydrofuran-3-yl (((2R,3S,5R)-5-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-3-hydroxytetrahydrofuran-2-yl)methyl) hydrogen phosphate. Grades: ≥95%. CAS No. 929901-49-5. Molecular formula: C18H24N9O10P. Mole weight: 557.41. | |
| SGI-1776 | SGI-1776 Inhibitor. Uses: Scientific use. Product Category: T3078. CAS No. 1025065-69-3. | |
| SGI-1776 | SGI-1776 is a small-molecule pan-Pim protein kinase inhibitor with potential antineoplastic activity. Pim kinase inhibitor SGI-1776 binds to and inhibits the activities of Pim-1, -2 and -3, serine-threonine kinases, which may result in the interruption of the G1/S phase cell cycle transition, the expression of pro-apoptotic Bcl2 proteins and tumor cell apoptosis. PIM kinases play key roles in cell cycle progression and apoptosis inhibition and may be overexpressed in various malignancies. Synonyms: SGI 1776; SGI 1776. Grades: >98%. CAS No. 1025065-69-3. Molecular formula: C20H22F3N5O. Mole weight: 405.425. | |
| SGI-1776 free base | SGI-1776 free base is an inhibitor of Pim kinases, with IC 50 s of 7 nM, 363 nM, and 69 nM for Pim-1, -2 and -3, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1025065-69-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-13287. | |
| SgI-29 | SgI-29 is an antibacterial peptide isolated from Homo sapiens. It has activity against gram-positive bacteria and gram-negative bacteria. Synonyms: SgI-29 (85-113); His-Asn-Lys-Gln-Glu-Gly-Arg-Asp-His-Asp-Lys-Ser-Lys-Gly-His-Phe-His-Arg-Val-Val-Ile-His-His-Lys-Gly-Gly-Lys-Ala-His. Grades: >97%. Molecular formula: C145H226N56O39. Mole weight: 3377.74. | |
| SGI-7079 | SGI-7079 Inhibitor. Uses: Scientific use. Product Category: T6982. CAS No. 1239875-86-5. | |
| SGI-7079 | This active molecular is a selective Axl inhibitor and Axl is a potential therapeutic target for overcoming EGFR inhibitor resistance. SGI-7079 significantly inhibits the proliferation of SUM149 or KPL-4 cells. IC50 value for SUM149 is 0.43 μM, 0.16 μM for KPL-4. It inhibited Axl activation in the presence of exogenous Gas6 ligand effectively. It will be a drug candidate as a anticancer agent. Uses: Anti-cancer. Synonyms: SGI-7079; SGI 7079; SGI7079. 2-(3-(2-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)acetonitrile. CAS No. 1239875-86-5. Molecular formula: C26H26FN7. Mole weight: 455.53. | |
| SgII peptide A | SgII peptide A is an antibacterial peptide isolated from Homo sapiens. It has activity against gram-positive bacteria, gram-negative bacteria and fungi. Synonyms: SgII peptide A (human); Lys-Gln-Glu-Gly-Arg-Asp-His-Asp-Lys-Ser-Lys-Gly-His-Phe-His-Met-Ile-Val-Ile-His-His-Lys-Gly-Gly-Gln-Ala-His-His-Gly. Grades: >97%. Molecular formula: C142H218N52O39S. Mole weight: 3309.68. | |
| SGK1 (?1-60, S422D), active human | recombinant, expressed in baculovirus infected Sf9 cells (truncated human sequence (a.a. 1-60 deleted, S422D mutation)-histidine-tagged), buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| SGK1 (60-end), active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| SGK1-IN-1 | SGK1-IN-1 is a highly active and selective inhibitor of SGK-1, with an IC50 of 1 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1279829-87-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18607. | |
| SGK1 Inhibitor | SGK1 Inhibitor is an inhibitor of serum- and glucocorticoid-regulated kinase 1 (SGK1) and SGK2 with IC50 values of 4.8 and 2.8 nM, respectively. It prevents phosphorylation of GSK3β in U2OS cells with IC50 value of 1.4 μM. Synonyms: SGK-1 Inhibitor; N-[4-(3-Amino-2H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2,3-dichlorobenzenesulfonamide. Grades: ≥95%. CAS No. 1426214-51-8. Molecular formula: C17H12Cl2N6O2S. Mole weight: 435.29. | |
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