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| Product | Description | |
|---|---|---|
| SF 2446A1 | SF 2446A1 is a quinone antibiotic produced by Steptomyces sp. SF2446. SF 2446A1, SF 2446A2, SF 2446B1 have potent activity against mycoplasma with MIC of 0.01-0.03μg/mL, and activity against gram-positive bacteria. Synonyms: Antibiotic SF 2446A1; SF2446A1. Molecular formula: C34H35NO15. Mole weight: 697.6. |  |
| SF 2446A2 | SF 2446A2 is a quinone antibiotic produced by Steptomyces sp. SF2446. SF 2446A1, SF 2446A2, SF 2446B1 have potent activity against mycoplasma with MIC of 0.01-0.03μg/mL, and activity against gram-positive bacteria. Synonyms: Antibiotic SF 2446A2; SF2446A2. Molecular formula: C34H35NO15. Mole weight: 697.6. | |
| SF 2446A3 | Synonyms: SF2446A3. CAS No. 115834-24-7. Molecular formula: C26H21NO11. Mole weight: 523.4. | |
| SF 2446B1 | SF 2446B1 is a quinone antibiotic produced by Steptomyces sp. SF2446. SF 2446A1, SF 2446A2, SF 2446B1 have potent activity against mycoplasma with MIC of 0.01-0.03μg/mL, and activity against gram-positive bacteria. Synonyms: Antibiotic SF 2446B1; SF2446B1. Molecular formula: C34H35NO14. Mole weight: 681.6. | |
| SF 2446B2 | Synonyms: SF2446B2. Molecular formula: C34H35NO14. Mole weight: 681.6. | |
| SF2457 | SF2457 is an antibiotic related to amicetin, which is isolated from the fermentation broth of Nocardia brasiliensis SF2457. It exhibits inhibitory activity against Gram-positive and Gram-negative bacteria. Synonyms: SF-2457; SF 2457. CAS No. 115748-04-4. Molecular formula: C27H38N6O9. Mole weight: 590.6. | |
| SF 2487 | SF 2487 is a polyether antibiotic produced by Actinomadura sp. SF2487. It has moderate activity against gram-positive bacteria including staphylococcus and enterococcus with MIC of 0.10-0.39 μg/mL. It also effective against Influenza A virus. Synonyms: SF-2487; SF2487; SF 2487 sodium salt; Antibiotic SF 2487 sodium salt; LS-70212. Molecular formula: C42H63NaO12. Mole weight: 782.9. | |
| SF2523 | SF2523 is a dual inhibitor of phosphatidylinositol 3-kinase and bromodomain-containing protein 4 with IC50 values of 34 nM, 158 nM, 9 nM, 241 nM and 280 nM for PI3Kα, PI3Kγ, DNA-PK, BRD4 and mTOR, respectively. In vivo SF2523 shows anti- tumor activity in xenograft studies. Synonyms: 3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-morpholin-4-ylthieno[3,2-b]pyran-7-one; SF-2523; SF 2523; CHEMBL2322228. CAS No. 1174428-47-7. Molecular formula: C19H17NO5S. Mole weight: 371.41. | |
| SF2738C | SF2738C is an antibiotic produced by the strain of Streptomyces sp. It has moderate activity against gram-positive, gram-negative bacteria and fungi. Synonyms: SF-2738C; SF 2738C. Molecular formula: C13H14N2O2S. Mole weight: 262.33. | |
| SF-331 | SF-331 is one of diaminoaryl-triazinenitrofurylhydrazones with an inhibitory effect on mycobacterium tuberculosis. Uses: Antibacterial agent. Synonyms: SF331; SF 331. | |
| SF5 | SF5 (2,2-Diphenylethyl isothiocyanate) is a sulforaphane analog. SF5 inhibits apoptosis by the JNK-p53-caspase pathway. SF5 can be used as a new renal protective agent for drug-resistant acute renal disease [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 2,2-Diphenylethyl isothiocyanate. CAS No. 34634-22-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116794. |  |
| SF-773α | SF-773α is an antibiotic produced by Streptomyces sp. It is active against gram-positive bacteria. Synonyms: SF 773&alpha. Molecular formula: C17H34N4O10. Mole weight: 454.5. | |
| SfaN I | One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 10-fold overdigestion with enzyme more than 95% of the dna fragments can be ligated and recut. Group: Restriction Enzymes. Purity: 500 U; 2500U. GCATC(N)5↑ CGTAG(N)9&darr. Activity: 10000u.a./ml. Appearance: 10 X SE-buffer O. Storage: -20°C. Form: Liquid. Source: An E.coli strain that carries the cloned SfaN I gene from Streptococcus faecalis N. Pack: 10 mM Tris-HCl (pH 7.5); 300 mM NaCl; 0,1 mM EDTA; 1 mM DTT; 200 μg/ml BSA; 50% glycerol. Cat No: ET-1172RE. |  |
| S-Farnesyl thioacetic acid | S-Farnesyl thioacetic acid has shown inhibitory effects against methylation of both farnesylated and geranylgeranylated substrates. It also inhibits Ca2+ influx through non-voltage-gated Ca2+ channels. Synonyms: FTA; [(3,7,11-trimethyldodeca-2,6,10-trien-1-yl)sulfanyl]acetic acid; Farnesylthoiacetic acid. Grades: ≥97%. CAS No. 135784-48-4. Molecular formula: C17H28O2S. Mole weight: 296.5. | |
| S-Fexofenadine (S-Carboxyterfenadine, S-Terfenadinecarboxyl ate) | A metabolite of of terfenadine, a H1-Histamine receptor antagonist. Group: Biochemicals. Alternative Names: S-Carboxyterfenadine, S-Terfenadinecarboxyl ate. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| Sfi I | One unit of the enzyme is the amount required to hydrolyze 1 μg of T7 DNA in 1 hour at 50°C in a total reaction volume of 50 μl. Applications: After 10-fold overdigestion with enzyme more than 70% of the dna fragments can be ligated and recut. in the presence of 10% peg ligation is better. Group: Restriction Enzymes. Purity: 1000U; 5000U. GGCCNNNN↑NGGCC CCGGN↓NNNNCCGG. Activity: 10000u.a./ml. Appearance: 10 X SE-buffer G, BSA. Storage: -20°C. Form: Liquid. Source: An E.coli strain, that carries the cloned gene Sfi I from Streptomyces fimbriatus. Pack: 10 mM Tris-HCl (pH 7.5); 200 mM NaCl; 0.1 mM EDTA; 7 mM 2-mercaptoethanol; 200 μg/ml BSA; 50% glycerol. Cat No: ET-1173RE. | |
| S-(+)-Flecainide | A stereoisomer of Flecainide. Flecainide is a class 1C antiarrhythmic drug especially used for the management of supraventricular arrhythmia. Synonyms: N-[(2S)-2-Piperidinylmethyl]-2,5-bis(2,2,2-trifluoroethoxy)benzamide; (S)-Flecainide; (+)-Flecainide. Grades: > 95%. CAS No. 99495-92-8. Molecular formula: C17H20F6N2O3. Mole weight: 414.35. | |
| S-(+)-Flecainide | S-(+)-Flecainide. Group: Biochemicals. Alternative Names: N-[ (2S) -2-Piperidinylmethyl]-2, 5-bis (2, 2, 2-trifluoroethoxy) benzamide. Grades: Highly Purified. CAS No. 99495-92-8. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C17H20F6N2O3. US Biological Life Sciences. | Worldwide |
| Sfllrnpndkyepf | Cas No. 137339-65-2. | |
| s-(+)-Fluoxetine hydrochloride | Heterocyclic Organic Compound. CAS No. 114247-06-2. Molecular formula: C17H19ClF3NO. Mole weight: 345.79. Catalog: ACM114247062. |  |
| S-Flurbiprofen-acyl-β-D-glucuronide | S-Flurbiprofen-acyl-β-D-glucuronide is an indispensably vital compound in the biomedical industry, exhibiting as an active metabolite of flurbiprofen. This extraordinary product assumes a pivotal role in the vast realm of studying diverse inflammatory ailments and efficaciously managing pain. Grades: > 95%. CAS No. 162992-66-7. Molecular formula: C21H21FO8. Mole weight: 420.39. | |
| S-Flurbiprofen Glucuronide | S-Flurbiprofen Glucuronide. Uses: For analytical and research use. Group: Impurity standards. CAS No. 162992-66-7. Molecular Formula: C21H21FO8. Mole Weight: 420.39. Catalog: APB162992667. |  |
| S-formylglutathione hydrolase | Also hydrolyses S-acetylglutathione, but more slowly. Group: Enzymes. Enzyme Commission Number: EC 3.1.2.12. CAS No. 83380-83-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3547; S-formylglutathione hydrolase; EC 3.1.2.12; 83380-83-0. Cat No: EXWM-3547. | |
| SF-PDI | Band gap: 2.1 eV. Group: Acceptor materials. Alternative Names: 1-(3-Butoxycarbonylpropyl)-1-phenyl-[6.6]C61. CAS No. 1643842-69-6. Molecular formula: C125H136N4O8. Mole weight: 1822.44. Canonical SMILES: O=C1N (C (CCCCCC) CCCCCC) C (C2=C (C1=CC=C3C4=C (C (C=C5) =CC6=C5C (C=CC (C7=CC8=C9C% 10=C7C% 11=C% 12C (C% 13=CC=C% 12C% 10=CC=C9C (N (C (CCCCCC) CCCCCC) C8=O) =O) =C (C (N (C (CCCCCC) CCCCCC) C% 13=O) =O) C=C% 11) =C% 14) =C% 14C6% 15C% 16=CC=CC=C% 16C% 17=C% 15C=CC=C% 17) C=C (C (N (C (CCCCCC) CCCCCC) C. Catalog: ACM1643842696. | |
| SF-PDI | Band gap: 2.1 eV. Group: Organic field effect transistor (ofet) materials organic solar cell (opv) materials. Alternative Names: 1-(3-Butoxycarbonylpropyl)-1-phenyl-[6.6]C61. CAS No. 1643842-69-6. Pack Sizes: 100 mg in glass bottle. Molecular formula: 1822.44. Mole weight: C125H136N4O8. O=C1N (C (CCCCCC) CCCCCC) C (C2=C (C1=CC=C3C4=C (C (C=C5) =CC6=C5C (C=CC (C7=CC8=C9C% 10=C7C% 11=C% 12C (C% 13=CC=C% 12C% 10=CC=C9C (N (C (CCCCCC) CCCCCC) C8=O) =O) =C (C (N (C (CCCCCC) CCCCCC) C% 13=O) =O) C=C% 11) =C% 14) =C% 14C6% 15C% 16=CC=CC=C% 16C% 17=C% 15C=CC=C% 17) C=C (C (N (C (CCCCCC) CCCCCC) C. InChI=1S / C125H136N4O8 / c1-9-17-25-33-45-79 (46-34-26-18-10-2) 126-117 (130) 93-67-61-87-89-63-69-97-113-101 (123 (136) 128 (121 (97) 134) 81 (49-37-29-21-13-5) 50-38-30-22-14-6) 75-99 (109 (115 (89) 113) 91-65-71-95 (119 (126) 132) 111 (93) 107 (87) 91) 77-57-59-85-86-60-58-78 (74-106 (86) 125 (105 (85) 73-77) 103-55-43-41-53-83 (103) 84-54-42-44-56-104 (84) 125) 100-76-102-114-98 (122 (135) 129 (124 (102) 137) 82 (51-39-31-23-15-7) 52-40-32-24-16-8) 70-64-90-88-62-68-94-112-96 (72-66-92 (108 (88) 112) 110 (100) 116 (90) 114) 120 (133) 127 (118 (94) 131) 80 (47-35-27-19-11-3) 48-36-28-20-12-4 / h41-44, 53-76, 79-82H, 9-40, 45-52H2, 1-8H3. FYQVTINZMWVMSE-UHFFFAOYSA-N. |  |
| Sfr274 I | One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA (Hind III-digest) in 1 hour at 50°C in a total reaction volume of 50 μl. Applications: After 20-fold overdigestion with enzyme 90% of the dna fragments can be ligated and recut. Group: Restriction Enzymes. Purity: 2000U; 10000U. C↑TCGAG GAGCT↓C. Activity: 20000u.a./ml. Appearance: 10 X SE-buffer B. Storage: -20°C. Form: Liquid. Source: Streptomyces fradiae 274. Pack: 10 mM Tris-HCl (pH 7.5); 50 mM KCl; 0.1 mM EDTA; 7 mM 2-mercaptoethanol; 200 μg/ml BSA; 50% glycerol. Cat No: ET-1174RE. | |
| Sfr303 I | One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 10-fold overdigestion with enzyme more than 90% of the dna fragments can be ligated and recut. Group: Restriction Enzymes. Purity: 1000U; 5000U. CCGC↑GG GG↓CGCC. Activity: 10000u.a./ml. Appearance: 10 X SE-buffer B. Storage: -20°C. Form: Liquid. Source: Streptomyces fradiae 303. Pack: 10 mM Tris-HCl (pH 7.5); 100 mM NaCl; 0.1 mM EDTA; 7 mM 2-mercaptoethanol; 200 μg/ml BSA; 50% glycerol. Cat No: ET-1175RE. | |
| SGA360 | SGA360 is a selective modulator of the aryl hydrocarbon receptor (AhR) that competitively binds to AhR (IC50 = 3 μM) and represses serum amyloid A 1 (SAA1) gene expression induced by IL-1β in Huh7 cells. It also exhibits anti-inflammatory activity. Synonyms: 3-(2,4-dimethoxyphenyl)-1-prop-2-enyl-7-(trifluoromethyl)indazole. Grades: ≥98%. CAS No. 680611-86-3. Molecular formula: C19H17F3N2O2. Mole weight: 362.4. | |
| SGA360 | SGA360. Group: Biochemicals. Alternative Names: 3-(2,4-Dimethoxyphenyl)-1-(2-propen-1-yl)-7-(trifluoromethyl)-1H-indazole; 1-Allyl-3-(2,4-dimethoxyphenyl)-7-(trifluoromethyl)-1H-indazole. Grades: Highly Purified. CAS No. 680611-86-3. Pack Sizes: 10mg. Molecular Formula: C19H17F3N2O2, Molecular Weight: 362.35. US Biological Life Sciences. | Worldwide |
| SGA360-d5 | SGA360-d5. Group: Biochemicals. Alternative Names: 3-(2,4-Dimethoxyphenyl)-1-(2-propen-1-yl)-7-(trifluoromethyl)-1H-indazol-d5; 1-Allyl-3-(2,4-dimethoxyphenyl)-7-(trifluoromethyl)-1H-indazole-d5. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C19H12D5F3N2O2, Molecular Weight: 367.38. US Biological Life Sciences. | Worldwide |
| SGC0946 | SGC0946 Inhibitor. Uses: Scientific use. Product Category: T3082. CAS No. 1561178-17-3. |  |
| SGC0946 | SGC0946 is a selective DOT1L H3K79 methyltransferase ) inhibitor, with an IC 50 of 0.3 nM. SGC0946 results in G1 arrest, inhibits potential of cell self-renewal and metastatic, also induces cell differentiation. SGC0946 can be used in studies of leukemia and solid tumors and also serve as a probe to further investigate the cellular mechanism of DOT1L in both normal and diseased cells [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1561178-17-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-15650. | |
| SGC 0946 | SGC0946 is a potent and selective inhibitor of DOT1L, which potently and selectively kills cells containing an MLL translocation. SGC0946 inhibits DOT1L with an IC50 of 0.3nM in a radioactive enzyme assay and is over 100-fold selective for other HMTs. Synonyms: SGC-0946; SGC 0946; SGC0946. Grades: >98%. CAS No. 1561178-17-3. Molecular formula: C28H40BrN7O4. Mole weight: 618.57. | |
| SGC-0946 | SGC-0946. Group: Biochemicals. Alternative Names: 1- (3- ( ( ( (2R, 3S, 4R, 5R) -5- (4-Amino-5-bromo-7H-pyrrolo [2, 3-d] pyrimidin-7-yl) -3, 4-di hydroxytetra hydrofuran-2-yl) methyl ) (isopropyl ) amino) propyl ) -3- (4- (tert-butyl) phenyl) urea. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C28H40BrN7O4, Molecular Weight: 618.57. US Biological Life Sciences. | Worldwide |
| SGC 0946 (1- [3- [ [ [ (2R, 3S, 4R, 5R) -5- (4-Amino-5-bromo-7H-pyrrolo [2, 3-d] pyrimidin-7-yl) -3, 4-di hydroxytetra hydrofuran-2-yl] methyl ] (isopropyl ) amino] propyl] -3- [4- (2, 2-di methyl ethyl) phenyl] urea) | Potent DOT1L methyltransferase inhibitor (KD = 0.06nm, IC50 = 0.3nm in a radioactive assay); blocks H3K79 methylation in A431 cells and MCF10A cells (IC50 values are 2.65 and 8.8nm respectively). Inactive at 12 histone methyltransferases and DNMT1. Selectively kills cells transformed with the MLL-AF9 fusion oncogene in an in vitro model of leukemia; lowers levels of MLL target genes HOXA9 and Meis1. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| SGC2085 | SGC2085 is a potent and selective inhibitor of coactivator associated arginine methyltransferase 1 ( CARM1 ) with an IC 50 of 50 nM. SGC2085 also selectively inhibits PRMT6 with an IC 50 value of 5.2 μM, but not other PRMT proteins [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1821908-48-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100565. | |
| SGC2085 | SGC2085, also called as GTPL9259, is a potent and selective Coactivator Associated Arginine Methyltransferase 1 (CARM1), which has an IC50 of 50 nM for CARM1 and is over 100-fold selective for CARM1 over PRMT6. Synonyms: SGC2085; SGC-2085; SGC 2085. Grades: 99.05 %. CAS No. 1821908-48-8. Molecular formula: C19H24N2O2. Mole weight: 312.41. | |
| SGC2085 HCl | SGC2085, also called as GTPL9259, is a potent and selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor with an IC50 of 50 nM and more than undred-fold selectivity over other PRMTs. Synonyms: SGC2085 HCl; SGC 2085 HCl; SGC-2085 HCl; (2S)-2-amino-N-[[4-(3, 5-dimethylphenoxy)-3-methylphenyl]methyl]propanamide; hydrochloride; 1821908-48-8 (SGC2085 free base). Grades: >98%. CAS No. 1821908-49-9. Molecular formula: C19H25ClN2O2. Mole weight: 348.87. | |
| SGC707 | SGC707 is a potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase?3 (PRMT3) with IC50 and Kd of 31 nM and 53 nM, respectively. Synonyms: SGC-707; SGC 707. Grades: 98%. CAS No. 1687736-54-4. Molecular formula: C16H18N4O2. Mole weight: 298.34. | |
| SGC AAK1 1 | SGC AAK1 1 is a potent and selective inhibitor of adaptor-associated protein kinase 1 (AAK1) and BMP-2-inducible protein kinase (BMP2K) inhibitor. It activates Wnt signaling. Synonyms: AAK1 inhibitor 1; N-(6-(3-((N,N-diethylsulfamoyl)amino)phenyl)-1H-indazol-3-yl)cyclopropanecarboxamide. Grades: ≥98% by HPLC. CAS No. 2247894-32-0. Molecular formula: C21H25N5O3S. Mole weight: 427.52. | |
| SGC-AAK1-1 | SGC-AAK1-1 is a potent and selective AAK1 (AP2 associated kinase 1) inhibitor with an IC 50 of 270 nM and a K i of 9 nM. SGC-AAK1-1 also potently inhibits BMP2K. SGC-AAK1-1 is used to study Wnt pathway related to AAK1 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2247894-32-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123940. | |
| SGC-CBP30 | SGC-CBP30 is a potent and selective inhibitor of CREBBP (CBP) and EP300; which are general transcriptional co-activators. Mutations of CREBBP and EP300 lead to Rubinstein-Taybi syndrome (RTS), characterised by growth retardation, facial abnormalities, organ abnormalities, mental retardation and altered tumor susceptibility. Synonyms: SGCCBP30; SGC CBP30. Grades: 0.98. CAS No. 1613695-14-9. Molecular formula: C28H33ClN4O3. Mole weight: 509.03962. | |
| SGC-CK2-1 | SGC-CK2-1 is a highly potent, ATP-competitive, and cell-active CK2 chemical probe with exclusive selectivity for both human CK2 isoforms, with IC 50 s of 36 and 16 nM for CK2α and CK2αrespectively in the nanoBRET assay. SGC-CK2-1 can be used for the research of neurodegenerative diseases [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2470424-39-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139004. | |
| SGC GAK 1 | SGC GAK 1 is a high affinity cyclin G associated kinase (GAK) inhibitor with >30-fold selectivity for GAK over a panel of other kinases. Synonyms: SGC-GAK-1; BCP30478; 6-Bromo-N-(3,4,5-trimethoxyphenyl)-4-quinolinamine. Grades: ≥99% by HPLC. CAS No. 2226517-76-4. Molecular formula: C18H17BrN2O3. Mole weight: 389.24. | |
| SGC-STK17B-1 | SGC-STK17B-1 is an ATP-competitive and selective STK17B (a member of DAPK family) inhibitor ( IC 50 : 34 nM, K D : 5.6 nM) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2650530-00-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-156350. | |
| SGI 1027 | SGI 1027. Group: Biochemicals. Grades: Purified. CAS No. 1020149-73-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SGI-1027 | SGI-1027 is a potent DNMT inhibitor, which reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degradation. Treatment of different cancer cell lines with SGI-1027 resulted in selective degradation of DNMT1 with minimal or no effects on DNMT3A and DNMT3B. SGI-1027 may have the potential for use in epigenetic cancer therapy. Synonyms: SGI 1027; SGI1027. Grades: 0.98. CAS No. 1020149-73-8. Molecular formula: C27H23N7O. Mole weight: 461.529. | |
| SGI 1027 dihydrochloride | SGI 1027 is a DNA methyltransferase (DNMT) inhibitor (IC50 values 35 μM and 10 μM for DNMT1 and DNMT3A2/3L, respectively). It was shown to degrade the enzymes and reactivate the silenced tumor suppressor genes (TSGs) P16, MLH1, and TIMP3 devoid of significant toxicity in a rat hepatoma (H4IIE) cell line. Synonyms: SGI 1027 dihydrochloride; SGI1027 dihydrochloride; SGI-1027 dihydrochloride; N-[4-[(2-Amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)benzamide dihydrochloride. Grades: 99%. CAS No. 2108487-01-8. Molecular formula: C27H25Cl2N7O. Mole weight: 534.44. | |
| SGI-110 | SGI-110 is a dinucleotide antimetabolite of a decitabine linked via phosphodiester bond to a guanosine, with potential antineoplastic activity. Following metabolic activation by phosphorylation and incorporation into DNA, SGI-110 inhibits DNA methyltransferase, thereby causing genome-wide and non-specific hypomethylation and inducing cell cycle arrest at S-phase. This agent is resistant to cytidine deaminase, hence may result in gradual release of decitabine both extra- and intracellularly, leading to more prolonged exposures to decitabine. Uses: Antineoplastic agents. Synonyms: Guadecitabine; SGI 110; SGI110; 2'-deoxy-5-azacytidylyl-(3'->5')-2'-deoxyguanosine; (2R,3S,5R)-5-(4-amino-2-oxo-1,3,5-triazin-1(2H)-yl)-2-(hydroxymethyl)tetrahydrofuran-3-yl (((2R,3S,5R)-5-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-3-hydroxytetrahydrofuran-2-yl)methyl) hydrogen phosphate. Grades: ≥95%. CAS No. 929901-49-5. Molecular formula: C18H24N9O10P. Mole weight: 557.41. | |
| Sgi-1776 | Heterocyclic Organic Compound. CAS No. 1173928-26-1. Molecular formula: C20H22F3N5O.2H2O4S. Mole weight: 601.573750 [g/mol]. Purity: 0.96. IUPACName: N-[ (1-methylpiperidin-4-yl)methyl]-3-[3- (trifluoromethoxy)phenyl]imidazo[1, 2-b]pyridazin-6-amine; sulfuric acid. Canonical SMILES: CN1CCC (CC1)CNC2=NN3C (=NC=C3C4=CC (=CC=C4)OC (F) (F)F)C=C2. OS (=O) (=O)O. OS (=O) (=O)O. Catalog: ACM1173928261. | |
| SGI-1776 | SGI-1776 Inhibitor. Uses: Scientific use. Product Category: T3078. CAS No. 1025065-69-3. | |
| SGI-1776 | SGI-1776 is a small-molecule pan-Pim protein kinase inhibitor with potential antineoplastic activity. Pim kinase inhibitor SGI-1776 binds to and inhibits the activities of Pim-1, -2 and -3, serine-threonine kinases, which may result in the interruption of the G1/S phase cell cycle transition, the expression of pro-apoptotic Bcl2 proteins and tumor cell apoptosis. PIM kinases play key roles in cell cycle progression and apoptosis inhibition and may be overexpressed in various malignancies. Synonyms: SGI 1776; SGI 1776. Grades: >98%. CAS No. 1025065-69-3. Molecular formula: C20H22F3N5O. Mole weight: 405.425. | |
| SGI-1776 free base | SGI-1776 free base is an inhibitor of Pim kinases, with IC 50 s of 7 nM, 363 nM, and 69 nM for Pim-1, -2 and -3, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1025065-69-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-13287. | |
| SgI-29 | SgI-29 is an antibacterial peptide isolated from Homo sapiens. It has activity against gram-positive bacteria and gram-negative bacteria. Synonyms: SgI-29 (85-113); His-Asn-Lys-Gln-Glu-Gly-Arg-Asp-His-Asp-Lys-Ser-Lys-Gly-His-Phe-His-Arg-Val-Val-Ile-His-His-Lys-Gly-Gly-Lys-Ala-His. Grades: >97%. Molecular formula: C145H226N56O39. Mole weight: 3377.74. | |
| SGI-7079 | This active molecular is a selective Axl inhibitor and Axl is a potential therapeutic target for overcoming EGFR inhibitor resistance. SGI-7079 significantly inhibits the proliferation of SUM149 or KPL-4 cells. IC50 value for SUM149 is 0.43 μM, 0.16 μM for KPL-4. It inhibited Axl activation in the presence of exogenous Gas6 ligand effectively. It will be a drug candidate as a anticancer agent. Uses: Anti-cancer. Synonyms: SGI-7079; SGI 7079; SGI7079. 2-(3-(2-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)acetonitrile. CAS No. 1239875-86-5. Molecular formula: C26H26FN7. Mole weight: 455.53. | |
| SGI-7079 | SGI-7079 Inhibitor. Uses: Scientific use. Product Category: T6982. CAS No. 1239875-86-5. | |
| SgII peptide A | SgII peptide A is an antibacterial peptide isolated from Homo sapiens. It has activity against gram-positive bacteria, gram-negative bacteria and fungi. Synonyms: SgII peptide A (human); Lys-Gln-Glu-Gly-Arg-Asp-His-Asp-Lys-Ser-Lys-Gly-His-Phe-His-Met-Ile-Val-Ile-His-His-Lys-Gly-Gly-Gln-Ala-His-His-Gly. Grades: >97%. Molecular formula: C142H218N52O39S. Mole weight: 3309.68. | |
| SGK1 Inhibitor | SGK1 Inhibitor is an inhibitor of serum- and glucocorticoid-regulated kinase 1 (SGK1) and SGK2 with IC50 values of 4.8 and 2.8 nM, respectively. It prevents phosphorylation of GSK3β in U2OS cells with IC50 value of 1.4 μM. Synonyms: SGK-1 Inhibitor; N-[4-(3-Amino-2H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2,3-dichlorobenzenesulfonamide. Grades: ≥95%. CAS No. 1426214-51-8. Molecular formula: C17H12Cl2N6O2S. Mole weight: 435.29. | |
| SGLT2-IN-1 | SGLT2-IN-1 (Compound 5) is an inhibitor for sodium-dependent glucose cotransporter ( SGLT2 ), with IC 50 of 33 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 864070-37-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-I1120. | |
| s-Glycidyl-4-nitrobenzene-sulfonate | Heterocyclic Organic Compound. CAS No. 128712-60-0. Purity: 0.96. Catalog: ACM128712600. | |
| S-(+)-Glycidyl tosylate | S-(+)-Glycidyl tosylate. Group: Biochemicals. Grades: Highly Purified. CAS No. 70987-78-9. Pack Sizes: 5g, 10g, 25g, 50g, 100g. US Biological Life Sciences. | Worldwide |
| sGnRH-A | sGnRH-A is a GnRH peptide analog that acts as a GnRH antagonist. Synonyms: H-Pyr-His-Trp-Ser-Tyr-D-Arg-Trp-Leu-Pro-NHEt. CAS No. 96497-82-4. Molecular formula: C64H83N17O12. Mole weight: 1282.45. | |
| SGR-1505 | SGR-1505 is an orally active MALT1 allosteric inhibitor. SGR-1505 inhibits MALT1 enzymatic activity and shows anti-proliferative activity in BTK inhibitor (BTKi)-sensitive and BTKi-resistant activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL) cell lines. SGR-1505 can be used for research of B-cell lymphomas [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2661481-41-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160698. | |
| sgRNA Screening Kit | sgRNA Screening Kit. Sgrna screening kit provides a simple, reliable, and rapid method for assessing sgrna efficiency before cell transduction, allowing you to identify the highly effective crispr sgrna. cas9 nuclease nls is an rna-guided endonuclease that catalyzes site-specific cleavage of double stranded dna. the location of the break is within the target sequence 3 bases from the ngg pam (protospacer adjacent motif). the design of single guide rna (sgrna) is dependent on the target region close to the pam site. even if you pick a target sequence that fulfills all of the described requirements, sgrna specificity and activity is unpredictable. therefore, it is often recommended that multiple, different sgrnas be designed to target a gene of interest. components. gencrispr cas9 nuclease. 10x reaction buffer. positive control sgrna. positive control substrate. rnase-free water. Group: Cloning Enzymes. Purity: 30 reactions/kit. Storage: Store at -20 ?. Source: E.coli. Pack: 10 mM Tris, 300 mM NaCl, 0.1 mM EDTA, 1 mM DTT, 50% Glycerol PH 7.4, at 25°C. Cat No: CE-3509. | |
| sgRNA Synthesis Kit | sgRNA Synthesis Kit. This product is designed to synthesize grnas in vitro. in the bacterial crispr/cas9 system, the cas9 nuclease associates with two rnas, the crispr rna (crrna) and the trans-activating crrna (tracrrna), to direct sequence-specific dna cleavage. the grna (guide rna) is a fusion of the natural crrna and tracrrna components. it contains an 18-20 base variable sequence that can be changed to target any dna sequence that is adjacent to an ngg proto-spacer adjacent motif (pam) on the 3 end of the target sequence. the sgrna synthesis kit allows user to fuse their choice of 18-20 base target sequence within the grna dna sequence provided, by pcr fusion. the kit also provides materials for in-vitro transcription of the generated grna dna in order to generate grnas which can be directly used for in-vivo genome editing. Group: Cloning Enzymes. Purity: 20 reactions/kit. Storage: Store at -20 ?. Source: E.coli. Pack: 10 mM Tris, 300 mM NaCl, 0.1 mM EDTA, 1 mM DTT, 50% Glycerol PH 7.4, at 25°C. Cat No: CE-3510. | |
| SGS 518 | SGS 518 is a selective 5-HT6 antagonist developed for the treatment of Cognitive Impairment Associated with Schizophrenia (CIAS). Uses: The treatment of cognitive impairment associated with schizophrenia (cias). Synonyms: SGS-518; LY 483518; SGS 518; SGS518; LY483518; LY-483518; 1-methyl-3-(1-methylpiperidin-4-yl)-1H-indol-5-yl 2,6-difluorobenzenesulfonate. Grades: 99%. CAS No. 445441-26-9. Molecular formula: C21H22F2N2O3S. Mole weight: 420.47. | |
| SGS 518 oxalate | SGS 518 oxalate is a selective 5-HT6 antagonist used for the treatment of cognitive impairment that is associated with schizophrenia and Alzheimer's disease. Synonyms: LY 483518; SGS 518 oxalate; LY483518; SGS518 oxalate; LY-483518; SGS-518 oxalate; 1-Methyl-3-(1-methyl-4-piperindin-4-yl)-5-hydroxy-1H-indole 2,6-difluorobenzenesulfonic acid ester oxalate. Grades: ≥98% by HPLC. CAS No. 445441-27-0. Molecular formula: C21H22F2N2O3S.C2H2O4. Mole weight: 510.51. | |
| SGS 518 oxalate | SGS 518 oxalate. Group: Biochemicals. Grades: Purified. CAS No. 445441-27-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SGX 523 | SGX 523. Group: Biochemicals. Grades: Purified. CAS No. 1022150-57-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SGX-523 | SGX523 is a novel, ATP-competitive kinase inhibitor remarkable for its exquisite selectivity for MET. SGX523 potently inhibited MET with an IC50 of 4 nmol/L and is >1,000-fold selective versus the >200-fold selectivity of other protein kinases tested in biochemical assays. Crystallographic study revealed that SGX523 stabilizes MET in a unique inactive conformation that is inaccessible to other protein kinases, suggesting an explanation for the selectivity. SGX523 inhibited MET-mediated signaling, cell proliferation, and cell migration at nanomolar concentrations but had no effect on signaling dependent on other protein kinases, including the closely related RON, even at micromolar concentrations. SGX523 inhibition of MET in vivo was associated with the dose-dependent inhibition of growth of tumor xenografts derived from human glioblastoma and lung and gastric cancers, confirming the dependence of these tumors on MET catalytic activity. Our results show that SGX523 is the most selective inhibitor of MET catalytic activity described to date and is thus a useful tool to investigate the role of MET kinase in cancer without the confounding effects of promiscuous protein kinase inhibition. Synonyms: SGX-523; SGX 523; SGX523. Grades: >98%. CAS No. 1022150-57-7. Molecular formula: C18H13N7S. Mole weight: 359.411. | |
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