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| Product | Description | |
|---|---|---|
| (S)-Ibrutinib | (S)-Ibrutinib. Group: Biochemicals. Alternative Names: 1-[(3S)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one; (S)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one. Grades: Highly Purified. CAS No. 936563-97-2. Pack Sizes: 5mg. Molecular Formula: C25H24N6O2, Molecular Weight: 440.5. US Biological Life Sciences. |  Worldwide |
| (S)-Ibrutinib | (S)-Ibrutinib is a highly selective Bruton's tyrosine kinase (Btk) irreversible inhibitor. Synonyms: 1-[(3S)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one; (S)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one. Grade: > 95%. CAS No. 936563-97-2. Molecular formula: C25H24N6O2. Mole weight: 440.51. |  |
| (S)-Ibrutinib-d5 | (S)-Ibrutinib-d5. Group: Biochemicals. Alternative Names: 1-[(3S)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one-d5; (S)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one-d5. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C25H19D5N6O2, Molecular Weight: 445.53. US Biological Life Sciences. | Worldwide |
| Dihydrodiol-Ibrutinib | Dihydrodiol-Ibrutinib, the dihydrodiol active metabolite of Ibrutinib, has about 15 times lower inhibitory activity against BTK than Ibrutinib. Synonyms: PCI-45227; Ibrutinib metabolite M37; 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2,3-dihydroxy-1-propanone; Ibrutinib Dihydrodiol R-Isomer; 1-((R)-3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-2,3-dihydroxypropan-1-one. Grade: ≥95%. CAS No. 1654820-87-7. Molecular formula: C25H26N6O4. Mole weight: 474.51. | |
| 1,3-bis((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-piperidin-1-yl)propan-1-one | An impurity of Ibrutinib, a medication used to treat refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Synonyms: 1-Propanone, 1,3-bis((3R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo(3,4-d)pyrimidin-1-yl)-1-piperidinyl)-; Ibrutinib impurity PDEJ. Grade: ≥95%. CAS No. 1987905-93-0. Molecular formula: C47H46N12O3. Mole weight: 826.97. | |
| 1,3-bis((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)propan-1-one | An impurity of Ibrutinib, a medication used to treat refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Synonyms: 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-3-((S)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)propan-1-one; Ibrutinib Impurity 15. Grade: 95% HPLC. CAS No. 1288338-97-5. Molecular formula: C47H46N12O3. Mole weight: 826.95. | |
| 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one | 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one. Group: Biochemicals. Alternative Names: Ibrutinib; PCI-32765. Grades: Highly Purified. CAS No. 936563-96-1. Pack Sizes: 250mg, 500mg, 1g, 2g, 5g. Molecular Formula: C25H24O2N6. US Biological Life Sciences. | Worldwide |
| 1-[4-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one | An impurity of Ibrutinib, a medication used to treat refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Synonyms: 2-Propen-1-one, 1-[4-[4-aMino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyriMidin-1-yl]-1-piperidinyl]-; Ibrutinib Impurity WZYG. Grade: ≥95%. CAS No. 936563-92-7. Molecular formula: C25H24N6O2. Mole weight: 440.50. | |
| 1-butyl-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | An impurity of Ibrutinib, a medication used to treat refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Synonyms: Ibrutinib Impurity IMDJ. Grade: ≥95%. CAS No. 2213398-77-5. Molecular formula: C21H21N5O. Mole weight: 359.43. | |
| 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-ethyl-3-(4-phenoxyphenyl)- | An impurity of Ibrutinib, a medication used to treat refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Synonyms: Ibrutinib Impurity IMYJ. Grade: ≥95%. CAS No. 2213398-76-4. Molecular formula: C19H17N5O. Mole weight: 331.37. | |
| 1-Methyl-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | An impurity of Ibrutinib, a medication used to treat refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Synonyms: 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-methyl-3-(4-phenoxyphenyl)-; Ibrutinib impurity JBZ. Grade: ≥95%. CAS No. 2213398-75-3. Molecular formula: C18H15N5O. Mole weight: 317.34. | |
| 1-((R)-3-(5-(3-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-3-oxopropyl)-4-imino-3-(4-phenoxyphenyl)-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one | An impurity of Ibrutinib, a medication used to treat refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Synonyms: 2-Propen-1-one, 1-[(3R)-3-[5-[3-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-3-oxopropyl]-4,5-dihydro-4-imino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]; Ibrutinib Impurity 14. CAS No. 2417548-76-4. Molecular formula: C50H48N12O4. Mole weight: 880.99. | |
| 2-(4-Phenoxybenzoyl)malononitrile | An impurity of Ibrutinib, a highly selective Bruton's tyrosine kinase (Btk) irreversible inhibitor used to treat refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Synonyms: Ibrutinib Impurity 36. Grade: ≥95%. CAS No. 2055156-76-6. Molecular formula: C16H10N2O2. Mole weight: 262.26. | |
| Dihydrodiol Ibrutinib | An impurity of Ibrutinib, a medication used to treat refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Synonyms: Ibrutinib Dihydrodiol; BTK-IN-3; PCI 45227; PCI-45227; 1-((S)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-2,3-dihydroxypropan-1-one. Grade: > 95%. CAS No. 1226872-27-0. Molecular formula: C25H26N6O4. Mole weight: 474.52. | |
| Ibrutinib | Ibrutinib Inhibitor. Uses: Scientific use. Product Category: T1835. CAS No. 936563-96-1. |  |
| Ibrutinib | Ibrutinib is a potent and selective BTK inhibitor (IC50=0.5 nM). Synonyms: PCI-32765; PCI 32765; (R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one. Grade: ≥95%. CAS No. 936563-96-1. Molecular formula: C25H24N6O2. Mole weight: 440.50. | |
| Ibrutinib | Ibrutinib (PCI-32765) is a selective, irreversible Btk inhibitor with an IC 50 of 0.5 nM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PCI-32765. CAS No. 936563-96-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-10997. |  |
| Ibrutinib-biotin | Ibrutinib-biotin is a probe that consists of Ibrutinib connected to biotin via a long chain linker with an IC50 of 0.755-1.02 nM for BTK. (Extracted from patent WO2014059368A1 Compound 1-5). Synonyms: Ibrutinib-biotin-1; N-(4-{[(2E)-4-{(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl}-4-oxo-2-buten-1-yl](methyl)amino}butyl)-N'-{15-oxo-19-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-4,7,10-trioxa-14-azanonadec-1-yl}pentanediamide. Grade: ≥98%. CAS No. 1599432-18-4. Molecular formula: C56H80N12O9S. Mole weight: 1097.37. | |
| Ibrutinib-d4 | Ibrutinib-d4 is the labelled analogue of Ibrutinib (I124970). Ibrutinib is a highly selective BrutonÂs tyrosine kinase (Btk) irreversible inhibitor. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C25H20D4N6O2, Molecular Weight: 444.52. US Biological Life Sciences. | Worldwide |
| Ibrutinib-[d5] | Ibrutinib-[d5] is the labelled analogue of Ibrutinib. Ibrutinib can be used to treat such cancers, including mantle cell lymphoma, chronic lymphocytic leukemia, and Waldenström macroglobulinemia. Synonyms: Ibrutinib D5. Grade: 98% by HPLC; 98% atom D. CAS No. 1553977-17-5. Molecular formula: C25H19D5N6O2. Mole weight: 445.53. | |
| Ibrutinib deacryloylpiperidine | Ibrutinib deacryloylpiperidine (IBT4A) is an impurity of Ibrutinib [1]. Ibrutinib is a selective, irreversible Btk inhibitor with an IC 50 of 0.5 nM [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: IBT4A. CAS No. 330786-24-8. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-78727. | |
| Ibrutinib Dimer | An impurity of Ibrutinib, a medication used to treat refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Synonyms: Ibrutinib impurity MDAEJ; 2-Propen-1-one, 1-[(3R)-3-[4-[[3-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-3-oxopropyl]amino]-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-; 1-((R)-3-(4-((3-((R)-3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-3-oxopropyl)amino)-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one. Grade: 95%. CAS No. 2031255-23-7. Molecular formula: C50H48N12O4. Mole weight: 880.99. | |
| Ibrutinib, Free Base | Ibrutinib, also known as PCI-32765, is a selective and irreversible inhibitor of the enzyme Bruton's tyrosine kinase (BTK). It inhibited BTK potently, with an IC50 of 0.72 nM in enzymology assays and with an IC50 of 10 nM in cellular assay with Ramos cells. It demonstrated preference toward BTK over closely related kinases, blocked B cell function and BTK-dependent processes, and demonstrated clear efficacy in a mouse arthritis model. Young P.R., et al. "Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase." ChemMedChem. 2: 58-61 (2007). Group: Biochemicals. Alternative Names: 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one; PCI 32765; PCI 32765-00; CRA 032765; (R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one; Imbruvica. Grades: Purified. CAS No. 936563-96-1. Pack Sizes: 5mg, 25mg, 50mg. US Biological Life Sciences. | Worldwide |
| Ibrutinib Impurity 1 | An impurity of Ibrutinib, a medication used to treat refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Synonyms: 1-Piperidinecarboxylic acid, 3-[4-aMino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyriMidin-1-yl]-, 1,1-diMethylethyl ester, (3R)-; (R)-tert-Butyl 3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate. Grade: > 95%. CAS No. 1022150-11-3. Molecular formula: C27H30N6O3. Mole weight: 486.58. | |
| Ibrutinib Impurity 18 | Ibrutinib Impurity 18. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (R)-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine. CAS No. 1022150-12-4. Molecular formula: C22H22N6O. Mole weight: 386.45. Catalog: APB1022150124. |  |
| Ibrutinib Impurity 2 | Ibrutinib Impurity 2. Grade: > 95%. Molecular formula: C28H26N6O3. Mole weight: 494.56. | |
| Ibrutinib Impurity 3-d5 | One of the isotopic labelled impurities of Ibrutinib, which has been found to be an irreversible inhibitor against Bruton's tyrosine kinase (Btk). Synonyms: 1-[3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2,3-dihydroxy-1-propanone-d5. Molecular formula: C25H21N6O4D5. Mole weight: 479.55. | |
| Ibrutinib Impurity 4 | Ibrutinib Impurity 4. Grade: > 95%. Molecular formula: C25H24N6O3. Mole weight: 456.51. | |
| Ibrutinib Impurity 5 | Ibrutinib Impurity 5 is an impurity in commercial preparation of Ibrutinib. Synonyms: (R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-3-chloropropan-1-one. Grade: > 95%. Molecular formula: C25H25ClN6O2. Mole weight: 476.97. | |
| Ibrutinib Impurity 6 | Ibrutinib Impurity 6. Synonyms: Ibrutinib impurity 6; 1987905-93-0; ZPJ4HT8UNA; UNII-ZPJ4HT8UNA; 1,3-Bis((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)propan-1-one (Imatinib Impurity); 1-Propanone, 1,3-bis((3R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo(3,4-d)pyrimidin-1-yl)-1-piperidinyl)-; 1,3-bis[(3R)-3-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-one; 3-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]-1-[(3R)-3-[4-imino-3-(4-phenoxyphenyl)-1H,2H,4H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-one; 1,3-bis((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-piperidin-1-yl)propan-1-one; 1,3-Bis((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)propan-1-one; 1,3-Bis((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)propan-1-one? (Imatinib Impurity; Ibrutinib Addition Adduct with (R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl). Grade: > 95%. Molecular formula: C47H46N12O3. Mole weight: 826.97. | |
| Ibrutinib Impurity 8 | Ibrutinib Impurity 8 is a useful synthetic intermediate in the synthesis of Ibrutinib, a highly selective Bruton's tyrosine kinase (BTK) irreversible inhibitor. Synonyms: 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; 5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine; 4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine; 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-(4-phenoxyphenyl)-; Ibrutinib intermeidate N-2. Grade: ≥97% by HPLC. CAS No. 330786-24-8. Molecular formula: C17H13N5O. Mole weight: 303.33. | |
| Ibrutinib Impurity HNEJ | An impurity of Ibrutinib, a medication used to treat refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Grade: ≥95%. Molecular formula: C49H46N12O4. Mole weight: 866.99. | |
| Ibrutinib Impurity IMYBJ | An impurity of Ibrutinib, a medication used to treat refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Grade: ≥95%. Molecular formula: C20H19N5O. Mole weight: 345.41. | |
| Ibrutinib Impurity JXBJ | An impurity of Ibrutinib, a medication used to treat refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Grade: ≥95%. Molecular formula: C26H26N6O2. Mole weight: 454.53. | |
| Ibrutinib Impurity MDDYH | An impurity of Ibrutinib, a medication used to treat refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Grade: ≥95%. CAS No. 2052279-49-7. Molecular formula: C25H24N6O3. Mole weight: 456.51. | |
| Ibrutinib Impurity SMSJ | An impurity of Ibrutinib, a medication used to treat refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Grade: ≥95%. Molecular formula: C32H24N8O2. Mole weight: 552.60. | |
| Ibrutinib Methoxy Impurity | An impurity of Ibrutinib, a medication used to treat refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Synonyms: (R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-3-methoxypropan-1-one; Ibrutinib impurity JYD. Grade: ≥95%. CAS No. 2031255-26-0. Molecular formula: C26H28N6O3. Mole weight: 472.55. | |
| Ibrutinib Racemate | Ibrutinib Racemate (PCI-32765 Racemate) is the racemate of Ibrutinib. Ibrutinib is a selective, irreversible Btk inhibitor with IC 50 value of 0.5 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PCI-32765 Racemate. CAS No. 936563-87-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10997A. | |
| JH-X-119-01 | Jh-X-119-01 is a novel potent and selective interleukin-1 receptor-associated kinases 1 (IRAK1) inhibitor. JH-X-119-01 irreversibly labels IRAK1 at C302. This compound exhibited cytotoxic activity at single digit micromolar concentrations in a panel of WM, DLBCL, and lymphoma cell lines expressing MYD88. Cotreatment of JH-X-119-01 with the BTK inhibitor ibrutinib resulted in synergistic killing effects in these systems. Uses: Designed for use in research and industrial production. Additional or Alternative Names: JH-X-119-01; JH-X119-01; JH-X 119-01; JH-X-11901; JH-X11901; JH-X 11901; JHX-11901; JHX11901; JHX 11901. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2227368-54-7. Molecular formula: C25H20N6O3. Mole weight: 452.47. Purity: >98%. IUPACName: N-(4-(3-Acrylamidobenzamido)phenyl)-6-(1H-pyrazol-5-yl)picolinamide. Canonical SMILES: O=C(NC1=CC=C(NC(C2=CC=CC(NC(C=C)=O)=C2)=O)C=C1)C3=NC(C4=CC=NN4)=CC=C3. Product ID: ACM2227368547. Alfa Chemistry ISO 9001:2015 Certified. |  |
| KIN-8194 | KIN-8194 is an orally active dual inhibitor of HCK and BTK, with IC50 values of 0.915 and <0.495 nM, respectively. KIN-8194 impairs growth and integrin-mediated adhesion of BTKi-resistant mantle cell lymphoma (MCL). KIN-8194 overcomes ibrutinib (HY-10997) resistance with a survival benefit in TMD-8 ABC DLBCL xenografted mice[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 330786-01-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15805. | |
| N1,N6 [ 1,3-(1-Oxopropylene)] Ibrutinib | N1,N6 [ 1,3-(1-Oxopropylene)] Ibrutinib is an impurity of Ibrutinib (I124970), a highly selective BrutonÂs tyrosine kinase (Btk) irreversible inhibitor. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 10mg. Molecular Formula: C28H26N6O3, Molecular Weight: 494.54. US Biological Life Sciences. | Worldwide |
| NX-2127 | NX-2127 (compound 28) is an orally active PROTAC deggrader, targeting to Brutons Tyrosine Kinase (Btk). NX-2127 inhibits proliferation of BTK C481S mutant TMD8 cells, more effectively than Ibrutinib (HY-10997). NX-2127 catalyzes the degradation of Ikaros (IKZF1) and Aiolos (IKZF3) with of 25 nM and 54 nM, respectively. NX-2127 stimulates T cell activation and increases IL-2 production in primary human T Cells [1] [2]. NX-2127 is composed of PROTAC target protein ligand (red part) BTK ligand 10 (HY-168302), E3 ligase ligand (blue part) Thalidomide 5-fluoride (HY-W087383) and PROTAC Linker (black part) (S)-4-(1-(Pyrrolidin-3-ylmethyl)piperidin-4-yl)aniline (HY-168303). Among which, the conjugate of E3 ubiquitin ligase ligand + Linker compose of Thalidomide-pyrrolidine-C-piperidine-Ph-NH2 (HY-168304). Uses: Scientific research. Group: Signaling pathways. CAS No. 2416131-46-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153220. | |
| ON-123300 | ON123300 is a potent multikinase inhibitor and may be potential useful for brain tumor chemotherapy. ON123300 strongly inhibits Ark5 and CDK4, as well as growth factor receptor tyrosine kinases such as β-type platelet-derived growth factor receptor (PDGFRβ). ON123300 inhibits U87 glioma cell proliferation with an IC(50) 3.4 ± 0.1 μmol/L. ON123300 exhibits potent activity against mantle cell lymphomas (MCLs) both in vitro and in vivo. ON123300 might be an effective agent in MCL, including ibrutinib-resistant forms of the disease. Uses: Designed for use in research and industrial production. Additional or Alternative Names: ON-123300; ON 123300; ON123300; Narazaciclib. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1357470-29-1. Molecular formula: C24H27N7O. Mole weight: 429. Purity: >98%. IUPACName: 8-cyclopentyl-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile. Canonical SMILES: N#CC1=CC2=CN=C(NC3=CC=C(N4CCN(C)CC4)C=C3)N=C2N(C5CCCC5)C1=O. Product ID: ACM1357470291. Alfa Chemistry ISO 9001:2015 Certified. | |
| (R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)ethanone | An impurity of Ibrutinib, a medication used to treat refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Synonyms: Ibrutinib impurity YX. Grade: ≥95%. CAS No. 1288338-95-3. Molecular formula: C24H24N6O2. Mole weight: 428.49. | |
| (R)-1-((R)-1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine 1-oxide | An impurity of Ibrutinib, a medication used to treat refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Synonyms: Ibrutinib Impurity BZDYH. Grade: ≥95%. CAS No. 2031255-25-9. Molecular formula: C25H24N6O3. Mole weight: 456.51. | |
| (R)-3-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-3-oxopropyl acrylate | An impurity of Ibrutinib, a medication used to treat refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Synonyms: 2-Propenoic acid, 3-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-3-oxopropyl ester; Ibrutinib Impurity BXSJC. Grade: ≥95%. CAS No. 2244619-11-0. Molecular formula: C28H28N6O4. Mole weight: 512.56. | |
| (R)-3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine dihydrochloride | An impurity of Ibrutinib, a medication used to treat refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Synonyms: 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-(4-phenoxyphenyl)-1-(3R)-3-piperidinyl-, hydrochloride (1:2); 3-(4-Phenoxyphenyl)-1-(3R)-3-piperidinyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine dihydrochloride; Ibrutinib Amino piperidine Dihydrochloride; Ibr-H dihydrochloride. Grade: ≥95%. CAS No. 1701403-10-2. Molecular formula: C22H22N6O.2HCl. Mole weight: 459.37. | |
| (R)-4-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carbonyl)pent-4-enoic acid | An impurity of Ibrutinib, a medication used to treat refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Synonyms: 1-Piperidinepentanoic acid, 3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-γ-methylene-δ-oxo-, (3R)-; (3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-γ-methylene-δ-oxo-1-piperidinepentanoic acid; Ibrutinib Impurity D; Ibrutinib Impurity 25. Grade: ≥95%. CAS No. 2052279-48-6. Molecular formula: C28H28N6O4. Mole weight: 512.57. | |
| (R)-8-(1-acryloylpiperidin-3-yl)-10-(4-phenoxyphenyl)-3,4-dihydropyrazolo[4,3-e]pyrimido[1,2-c]pyrimidin-2(8H)-one | An impurity of Ibrutinib, a medication used to treat refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Synonyms: Ibrutinib Impurity MDGH. Grade: ≥95%. CAS No. 1917333-91-5. Molecular formula: C28H26N6O3. Mole weight: 494.54. | |
| (Rac)-IBT6A hydrochloride | (Rac)-IBT6A hydrochloride is a racemate of IBT6A hydrochloride, and an impurity of Ibrutinib. It is also a Btk inhibitor. Synonyms: Ibrutinib analog hydrochloride; Btk inhibitor 1 hydrochloride; 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-(4-phenoxyphenyl)-1-(3-piperidinyl)-, hydrochloride (1:1); 3-(4-Phenoxyphenyl)-1-(3-piperidinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine hydrochloride (1:1). Grade: ≥95%. Molecular formula: C22H23ClN6O. Mole weight: 422.91. | |
| (R)-N-Desacryloyl N-3-Propionyl Ibrutinib | An impurity of Ibrutinib, a medication used to treat refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Synonyms: (R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-3-chloropropan-1-one. Grade: ≥95%. CAS No. 1288338-96-4. Molecular formula: C25H25ClN6O2. Mole weight: 476.96. | |
| (R)-N-Desacryloyl N-Propionyl Ibrutinib | An impurity of Ibrutinib, a medication used to treat refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Synonyms: 1-Propanone, 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-. Grade: ≥95%. CAS No. 1839099-22-7. Molecular formula: C25H26N6O2. Mole weight: 442.51. | |
| (S)-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | An impurity of Ibrutinib, a medication used to treat refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Synonyms: Ibrutinib impurity SYGIM. Grade: ≥95%. CAS No. 1642630-12-3. Molecular formula: C22H22N6O. Mole weight: 386.45. | |
| (S)-tert-butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate | An impurity of Ibrutinib, a medication used to treat refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Synonyms: 1-Piperidinecarboxylic acid, 3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-, 1,1-dimethylethyl ester, (3S)-; Ibrutinib Impurity 08. CAS No. 1642571-08-1. Molecular formula: C27H30N6O3. Mole weight: 486.57. | |
| (±)-Zanubrutinib | (±)-Zanubrutinib is a potent, selective and orally available Bruton's tyrosine kinase (Btk) inhibitor that demonstrates superior oral bioavailability, achieving higher exposure and more complete target inhibition in the tissues than ibrutinib. Uses: Antineoplastic agents. Synonyms: Pyrazolo[1,5-a]pyrimidine-3-carboxamide, 4,5,6,7-tetrahydro-7-[1-(1-oxo-2-propen-1-yl)-4-piperidinyl]-2-(4-phenoxyphenyl)-; 4,5,6,7-Tetrahydro-7-[1-(1-oxo-2-propen-1-yl)-4-piperidinyl]-2-(4-phenoxyphenyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide; 7-(1-Acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide; DL-Zanubrutinib; (±)-BGB-3111. CAS No. 1633350-06-7. Molecular formula: C27H29N5O3. Mole weight: 471.55. | |
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