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2-Methylpyridine-3-boronicacidpinacolester. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 2-Methylpyridine-3-boronic acid pinacol ester;2-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-pyridine. Product Category: Boronic Esters. CAS No. 1012084-56-8. Molecular formula: C12H18BNO2. Mole weight: 237.1031. Purity: 0.97. IUPACName: 2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine. Canonical SMILES: B1(OC(C(O1)(C)C)(C)C)C2=C(N=CC=C2)C. Density: 1.02 g/cm³. Product ID: ACM1012084568. Alfa Chemistry ISO 9001:2015 Certified.
2-Methylpyridine-3-carboxylic acid
2-Methylpyridine-3-carboxylic acid. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 2-Methylnicotinic acid. Product Category: Pyridines. Appearance: Powder. CAS No. 3222-56-8. Molecular formula: C7H7NO2. Mole weight: 137.14. Product ID: ACM3222568. Alfa Chemistry ISO 9001:2015 Certified.
2-Methylpyridine-4-boronic acid
2-Methylpyridine-4-boronic acid. Uses: Designed for use in research and industrial production. Product Category: Boronic Acids. CAS No. 579476-63-4. Product ID: ACM579476634. Alfa Chemistry ISO 9001:2015 Certified.
2-Methylpyridine-4-carboxaldehyde. Group: Biochemicals. Alternative Names: 2- methyl isonicotinaldehyde; 4-Formyl-2-methylpyridine. Grades: Highly Purified. CAS No. 63875-01-4. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. Molecular Formula: C7H7NO. US Biological Life Sciences.
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2-Methylpyridine-5-boronic acid
2-Methylpyridine-5-boronic acid. Group: Biochemicals. Alternative Names: 6-Methylpyridine-3-boronic acid; 2-Picoline-5-boronic acid. Grades: Highly Purified. CAS No. 659742-21-9. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. Molecular Formula: C6H8BNO2. US Biological Life Sciences.
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2-Methylpyridine 99+%
2-Methylpyridine 99+%. Group: Biochemicals. Grades: Reagent Grade. CAS No. 109-06-8. Pack Sizes: 25g, 100g, 250g. US Biological Life Sciences.
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2-Methyl-3-Cyanopyridine
2-Methyl-3-Cyanopyridine. Group: Biochemicals. Alternative Names: 2-Methylpyridine-3-carbonitrile. Grades: Highly Purified. CAS No. 1721-23-9. Pack Sizes: 250mg, 500mg, 1g, 2g, 5g. US Biological Life Sciences.
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2-Methyl-4-hydroxypyridine
2-Methyl-4-hydroxypyridine is used in the synthesis of novel indolizine compounds as inhibitors of phosphodiesterase IV. Also used in the preparation of 2-substituted imidazole ring compoiunds for treatment againast human African trypanosomiasis. Group: Biochemicals. Alternative Names: 2-Methylpyridin-4-ol; 4-Hydroxy-2-methylpyridine; 2-Methyl-4-pyridinol. Grades: Highly Purified. CAS No. 18615-86-6. Pack Sizes: 1g. Molecular Formula: C?H?NO, Molecular Weight: 109.13. US Biological Life Sciences.
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2-Picoline N-oxide
2-Picoline N-oxide. Group: Biochemicals. Alternative Names: 2-Methylpyridine N-oxide; 2-Methylpyridine 1-oxide. Grades: Highly Purified. CAS No. 931-19-1,51279-53-9. Pack Sizes: 250g, 500g, 1kg. US Biological Life Sciences.
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4-Pyridinecarbonylchloride
4-Pyridinecarbonylchloride. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 2-METHYL-4-PYRIDINECARBONYL CHLORIDE, 99911-04-3, 4-PYRIDINECARBONYL CHLORIDE, 2-METHYL-, 2-methylpyridine-4-carbonyl Chloride, AGN-PC-00G6EZ, CTK3I5784, 2-METHYLISONICOTINOYL CHLORIDE, 4-Pyridinecarbonylchloride, 2-methyl-, AKOS006302274, AB60195, AG-I-02786. Product Category: Heterocyclic Organic Compound. CAS No. 99911-04-3. Molecular formula: C7H6ClNO. Mole weight: 155.581640 [g/mol]. Purity: 0.96. IUPACName: 2-methylpyridine-4-carbonyl chloride. Canonical SMILES: CC1=NC=CC(=C1)C(=O)Cl. Product ID: ACM99911043. Alfa Chemistry ISO 9001:2015 Certified.
6-Methyl-2-pyridinylboronic acid MIDA ester
6-Methyl-2-pyridinylboronic acid MIDA ester. Group: Salt. Alternative Names: 2-Methylpyridine-6-boronic acid MIDA ester, 6-Methylpyridine-2-boronic acid MIDA ester, 6-Methyl-2-pyridinylboronic acid MIDA ester, 2-(6-Methyl-2-pyridinyl)-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione, 1227700-42-6. CAS No. 1227700-42-6. Product ID: 6-methyl-2-(6-methylpyridin-2-yl)-1,3,6,2-dioxazaborocane-4,8-dione. Molecular formula: 248.04. Mole weight: C11H13BN2O4. AHYYPYSUORBPCY-UHFFFAOYSA-N. 96%.
2-Methyl-1,10-phenanthroline. Group: Biochemicals. Alternative Names: 2-Methylpyridino[3,2-h]quinoline. Grades: Highly Purified. CAS No. 3002-77-5. Pack Sizes: 1g, 2g, 5g, 10g, 25g. Molecular Formula: C13H10N2. US Biological Life Sciences.
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(2-Methylpyridin-3-yl)acetonitrile
Used in the preparation of pyridine analogues of vitamin B1. Group: Biochemicals. Alternative Names: 2-Methyl-3-pyridineacetonitrile. Grades: Highly Purified. CAS No. 101166-73-8. Pack Sizes: 50mg. US Biological Life Sciences.
ARRY-403 is an orally available Glucokinase stimulants originated by Array BioPharma. ARRY-403 activates human glucokinase in vitro with EC50 of 79 nM at 5 mM glucose and Vmax = 134% compared to the no activator control. It exhibits good in vitro drug-like properties and selectivity against broad panels of receptors and enzymes. But,treatment for Type 2 diabetes mellitus was discontinued. Uses: Type 2 diabetes mellitus. Synonyms: ARRY-403; ARRY-403; ARRY-403; AMG-151; AMG 151; AMG151;(1S)-1-[5-({3-[(2-methylpyridin-3-yl)oxy]-5-(pyridin-2-ylsulfanyl)pyridin-2-yl}amino)-1,2,4-thiadiazol-3-yl]ethane-1,2-diol. Grades: 98%. CAS No. 1304015-76-6. Molecular formula: C20H18N6O3S2. Mole weight: 454.53.
AS-2444697 HCl
AS-2444697 is a pootent and selective interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor (IC50 = 21 nM) with 30-fold selectivity for IRAK4 over IRAK1. AS2444697 significantly reduced or showed a decreasing trend in expression and levels of these inflammatory parameters. Synonyms: N-(3-carbamoyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-2-(2-methylpyridin-4-yl)oxazole-4-carboxamide hydrochloride; AS-2444697; AS 2444697; AS2444697; AS-2444697 HCl; AS-2444697 hydrochloride. CAS No. 1287665-60-4. Molecular formula: C19H21ClN6O4. Mole weight: 432.86.
Emavusertib
Emavusertib, also known as CA-4948 is a potent IRAK4/FLT3 inhibitor with anti-tumor activity. CA-4948 demonstrated good cellular activity in ABC DLBCL and AML cell lines. CA-4948 demonstrated moderate to high selectivity in a panel of 329 kinases as well as exhibited desirable ADME and PK profiles including good oral bioavailability in mice, rat, and dog and showed >90% tumor growth inhibition in relevant tumor models with excellent correlation with in vivo PD modulation. Uses: Designed for use in research and industrial production. Additional or Alternative Names: CA-4948; CA 4948; CA4948; Emavusertib. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1801344-14-8. Molecular formula: C24H25N7O5. Mole weight: 491.51. Purity: >98%. IUPACName: (R)-N-(5-(3-hydroxypyrrolidin-1-yl)-2-morpholinooxazolo[4,5-b]pyridin-6-yl)-2-(2-methylpyridin-4-yl)oxazole-4-carboxamide. Canonical SMILES: O=C(C1=COC(C2=CC(C)=NC=C2)=N1)NC3=C(N4C[C@H](O)CC4)N=C5C(OC(N6CCOCC6)=N5)=C3. Product ID: ACM1801344148. Alfa Chemistry ISO 9001:2015 Certified.
GW1929
Potent and subtype-selective (>1000-fold) PPARgamma agonist. Angiogenesis and apoptosis inhibitor. Anti-inflammatory. Anti-hyperglycemic and anti-hyperlipidemic agent. GW1929 is an antidiabetic; the glucose-lowering effect in rats is 100-fold more potent than that of troglitazone. Group: Biochemicals. Alternative Names: N-(2-Benzoylphenyl)-L-tyrosine PPARγ Agonist; (2S) - ( (2-Benzoylphenyl) amino-3- [4- [2- (methylpyridin-2-ylamino) ethoxy] phenyl] propionic acid. Grades: Highly Purified. CAS No. 196808-24-9. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C30H29N3O4. US Biological Life Sciences.
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LGK974
LGK974 is a selective and orally bioavailable Porcupine inhibitor under development for the treatment of cancers that are driven by the Wnt pathway in a Wnt ligand-dependent manner. LGK974 was shown to induce tumor regression in a Wnt-driven murine tumor model. Synonyms: LGK-974; WNT-974; 2-(2',3-Dimethyl-[2,4'-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide; 2-[5-methyl-6-(2-methylpyridin-4-yl)pyridin-3-yl]-N-(5-pyrazin-2-ylpyridin-2-yl)acetamide. Grades: >98%. CAS No. 1243244-14-5. Molecular formula: C23H20N6O. Mole weight: 396.454.
LGK974 (LGK-974, WNT-974, LGK 974, NVP-LGK974)
LGK974 is a highly potent inhibitor of Porcupine (PORCN), a Wnt-specific acyltransferase. LGK974 is orally bioavailable and inhibits WNT signaling in vitro and in vivo. It is reported to exhibit anti-tumor properties without increasing cytotoxicity. Group: Biochemicals. Alternative Names: 2-[5-methyl-6-(2-methylpyridin-4-yl)pyridin-3-yl]-N-(5-pyrazin-2-ylpyridin-2-yl)acetamide; LGK-974; WNT-974; LGK 974; NVP-LGK974; 2,3-Dimethyl-N-[5-(2-pyrazinyl)-2-pyridinyl]-[2,4-bipyridine]-5-acetamide; 2-(2,3-Dimethyl-[2,4-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide. Grades: Highly Purified. CAS No. 1243244-14-5. Pack Sizes: 1mg, 5mg, 25mg, 100mg. Molecular Formula: C??H??N?O, Molecular Weight: 396.44. US Biological Life Sciences.
Worldwide
MAK683
MAK683 is an inhibitor of embryonic ectoderm development protein (EED) with potential antineoplastic activity. MAK683 binds to the domain of EED that interacts with trimethylated lysine 27 on histone 3 (H3K27me3), leading to a conformational change in the EED H3K27me3-binding pocket and preventing the interaction of EED with the histone methyltransferase enhancer zeste homolog 2 (EZH2). MAK683 is undergoing phase II clinical trials for the identification of antitumor activity. Synonyms: MAK-683; MAK 683; MAK683; EED inhibitor-1; N-[(5-fluoro-2,3-dihydro-1-benzofuran-4-yl)methyl]-8-(2-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine. Grades: 98%. CAS No. 1951408-58-4. Molecular formula: C20H17FN6O. Mole weight: 376.395.
PF-04171327
PF-04171327 is a dissociated agonist of the glucocorticoid receptor (DAGR), which is a selective high-affinity partial agonist of the GR. It has potent anti-inflammatory activity at exposures which provide less undesirable effects on bone and glucose metabolism. It is used to the treatment of rheumatoid arthritis. It was developed by Pfizer and was terminated in clinic phase 2. Uses: Pf-04171327 has potent anti-inflammatory activity. it is used to the treatment of rheumatoid arthritis. Synonyms: PF-04171327; PF04171327; PF 04171327; PF-4171327; PF4171327; PF 4171327; Fosdagrocorat;(2R,4aS,10aR)-4a-benzyl-7-((2-methylpyridin-3-yl)carbamoyl)-2-(trifluoromethyl)-1,2,3,4,4a,9,10,10a-octahydrophenanthren-2-yl dihydrogen phosphate. Grades: >98 %. CAS No. 1044535-58-1. Molecular formula: C29H30F3N2O5P. Mole weight: 574.53.
Porcn Inhibitor II, C59 (Wnt-C59, Wnt Pathway Inhibitor XVI, 2-(4-(2-Methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide)
A cell-permeable pyridinylphenyl-acetamide that is much more potent than IWP-2 in inhibiting MBOAT family member Porcupine-mediated Wnt palmitoylation (IC50 = 74 pM in STF reporter assays using Wnt3a-transfected HEK293). Shown to be effective against Porcn of murine and human, but not xenopus, species and potently inhibit the processing of both canonical and non-canonical Wnt subtypes. C59 is demonstrated to be orally active and effectively suppress MMTV-WNT1 tumor expansion in mice (5mg/kg & 10mg/kg p.o.) in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 1243243-89-1. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
SB 242084
SB 242084 is a brain-penetrant antagonist of 5-HT2C receptor which exhibits 158-fold selectivity for 5-HT2C (pKi= 9.0) over 5-HT2A receptor (pKi= 6.1-6.8) and 100-fold selectivity over 5-HT2B receptor (pKi= 6.8-7.0). Synonyms: SB 242084; SB242084; SB-242084; 6-chloro-5-methyl-N-[6-(2-methylpyridin-3-yl)oxypyridin-3-yl]-2,3-dihydroindole-1-carboxamide;dihydrochloride181632-25-76-Chloro-5-methyl-N-(6-((2-methylpyridin-3-yl)oxy)pyridin-3-yl)indoline-1-carboxamide dihydrochlorideSB 242084 (hydrochloride)6-chl. CAS No. 181632-25-7. Molecular formula: C21H19ClN4O2. Mole weight: 394.85.
Wnt Antagonist, C59
Cell-permeable. A potent Wnt signaling pathway inhibitor (IC50 = <0.11nM using Wnt-Luc reporter assay). Group: Biochemicals. Alternative Names: 2-(4-(2-Methylpyridin-4-yl)phenyl)-N-4-(pyridin-3-yl)phenyl) Acetamide. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Wnt-C59
Wnt-C59 is a potent and highly selective Wnt signaling antagonist with an IC50 ~ 74 pM in the Wnt signaling reporter assay. It was shown to arrest stemness and suppress growth of nasopharyngeal carcinoma in mice via Wnt pathway inhibition. Synonyms: 2-(4-(2-methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide. Grades: >98%. CAS No. 1243243-89-1. Molecular formula: C25H21N3O. Mole weight: 379.45.
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