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| Product | Description | |
|---|---|---|
| 5(6)-FAM SE | 5(6)-FAM SE is a green fluorescent dye widely used for protein labeling. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: 5(6)-Carboxyfluorescein N-hydroxysuccinimide ester; 5(6)-Carboxyfluorescein succinimidyl ester mixed isomers. CAS No. 117548-22-8. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15937. |  |
| 5(6)-FAM, SE | 5(6)-FAM, SE. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 5-(and-6)-Carboxyfluorescein, succinimidyl ester. Product Category: Fluorescein Fluorophores. CAS No. 117548-22-8. Molecular formula: C25H15NO9. Mole weight: 473.39. Product ID: ACM117548228. Alfa Chemistry ISO 9001:2015 Certified. Categories: NHS-FLUORESCEIN. |  |
| 3'-(6-FAM) CPG | 3'-(6-FAM) CPG, a powerful modified nucleotide utilized in the biomedical industry for generating fluorescent-labeled oligonucleotides, serves as an instrumental tool in numerous gene expression profiling, SNP genotyping, and nucleic acid-based research applications. With enhanced cellular uptake, this modification opens pathways for potential therapeutics in diseases like cancer and viral infections. Synonyms: 3'-(6-FAM) CPG 1000Å; 1-Dimethoxytrityloxy-3-[O-(N-carboxy-(di-O-pivaloyl-fluorescein)-3-aminopropyl)]-propyl-2-O-succinoyl-long chain alkylamino-CPG; 6-FAM lcaa CPG (DMT) 500Å. |  |
| 3'-(6-FAM) PS | 3'-(6-FAM) PS: a phosphorothioate oligonucleotide labeled with fluorescence, notorious in biomedical research as a nucleic acid detection probe. Its fluorescence can assist in DNA or RNA sample identification and quantification, utilizing prominent applications like PCR, hybridization, and sequencing. On top of all that, this product holds significant therapeutic value for sequencing-based diagnostics and drug discovery. Synonyms: 1-Dimethoxytrityloxy-3-[O-(N-carboxy-(di-O-pivaloyl-fluorescein)-3-aminopropyl)]-propyl-2-O-succinoyl-polystyrene. Mole weight: 569.46. | |
| 5(6)-Carboxyfluorescein | 5(6)-Carboxyfluorescein (5(6)-FAM) is an amine-reactive pH-sensitive green fluorescent probe. 5(6)-Carboxyfluorescein (5(6)-FAM) can be used to label proteins, peptides and nucleotides. 5(6)-Carboxyfluorescein can be used for the detection of tumour areas in vivo [1] [2]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: 5(6)-FAM; 5-(and-6)-Carboxyfluorescein mixed isomers. CAS No. 72088-94-9. Pack Sizes: 500 mg; 1 g. Product ID: HY-15940. | |
| 5(6)-Carboxyfluorescein succinimidyl ester | 5(6)-Carboxyfluorescein succinimidyl ester. Group: Biochemicals. Alternative Names: 5(6)-FAM SE. Grades: Highly Purified. CAS No. 117548-22-8. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C25H15NO9. US Biological Life Sciences. |  Worldwide |
| 5(6)-SFX SE | 5(6)-SFX SE. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 5(6)-FAM-X SE , Fluorescein-5(6)-carboxamidocaproic acid N-succinimidyl ester , 6-(Fluorescein-5(6)-carboxamido)hexanoic acid N-succinimidyl ester. Product Category: Fluorescein Fluorophores. Appearance: Yellow to orange powder. CAS No. 114616-31-8. Molecular formula: C31H26N2O10. Mole weight: 586.55. Purity: 90%+. Product ID: ACM114616318. Alfa Chemistry ISO 9001:2015 Certified. | |
| 5-FAM-Amyloid β-Protein (1-42) | 5-FAM-Amyloid β-Protein (1-42). Synonyms: 5-FAM-Aβ42; Fluorescein-5-carbonyl-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH; N6-[(3',6'-Dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl)carbonyl]-L-alpha-aspartyl-L-alanyl-L-alpha-glutamyl-L-phenylalanyl-L-arginyl-L-histidyl-L-alpha-aspartyl-L-serylglycyl-L-tyrosyl-L-alpha-glutamyl-L-valyl-L-histidyl-L-histidyl-L-glutaminyl-L-lysyl-L-leucyl-L-valyl-L-phenylalanyl-L-phenylalanyl-L-alanyl-L-alpha-glutamyl-L-alpha-aspartyl-L-valylglycyl-L-seryl-L-asparaginyl-L-lysylglycyl-L-alanyl-L-isoleucyl-L-isoleucylglycyl-L-leucyl-L-methionyl-L-valylglycylglycyl-L-valyl-L-valyl-L-isoleucyl-L-alanine. Grade: ≥95%. CAS No. 1802087-78-0. Molecular formula: C224H321N55O66S. Mole weight: 4872.41. | |
| 5-FAM-Woodtide | 5-FAM-Woodtide, the FAM-labeled Forkhead derived peptide woodtide (ab/em = 494/521 nm), is used as a substrate for the DYRK kinase family in vitro analysis. Woodtide corresponds to 324-334 residues of transcription factor FKHR with two lysine residues added at the N-terminus to facilitate binding to phosphocellulose paper. Synonyms: 5-FAM-Forkhead-derived Peptide; Fluorescein-5-carbonyl-Lys-Lys-Ile-Ser-Gly-Arg-Leu-Ser-Pro-Ile-Met-Thr-Glu-Gln-NH2; N2-[(3',6'-Dihydroxy-3-oxo-3H-spiro[2-benzofuran-1,9'-xanthen]-5-yl)carbonyl]-L-lysyl-L-lysyl-L-isoleucyl-L-serylglycyl-L-arginyl-L-leucyl-L-seryl-L-prolyl-L-isoleucyl-L-methionyl-L-threonyl-L-α-glutamyl-L-glutamamide. Grade: ≥95%. CAS No. 1566528-51-5. Molecular formula: C89H133N21O26S. Mole weight: 1945.23. | |
| 5-Propargylamino-CTP - 6-FAM | 5-Propargylamino-CTP - 6-FAM, a fluorescent nucleotide analog, is a pivotal entity in the biomedical milieu that enables researchers to study RNA synthesis and localization. This versatile compound can be assimilated into RNA for real-time monitoring of transcript dynamics in vivo. Its groundbreaking potential does not just stop there, it can also give insights into RNA localization and stability changes seen in an array of diseases such as cancer and neurodegenerative disorders. Synonyms: 5-Propargylamino-cytidine-5'-triphosphate, labeled with 6 FAM, Triethylammonium salt. Grade: ≥ 95% by HPLC. Molecular formula: C33H29N4O20P3 (free acid). Mole weight: 894.52 (free acid). | |
| 5-Propargylamino-dCTP - 6-FAM | 5-Propargylamino-dCTP - 6-FAM, a nucleotide analog, finds specialized use in the nucleic acid research realm. A biochemical tool that enables DNA labeling and visualization via fluorescent microscopy, it can be employed in diverse genetic analysis techniques like polymerase chain reaction (PCR) and DNA sequencing. With its synthetic incorporation capabilities, it aids in efficient DNA synthesis, ultimately enabling deeper insights into the intricacies of nucleic acid structure and function. Synonyms: 5-Propargylamino-2'-deoxycytidine-5'-triphosphate, labeled with 6 FAM, Triethylammonium salt. Grade: ≥ 95% by HPLC. Molecular formula: C33H29N4O19P3 (free acid). Mole weight: 878.52 (free acid). | |
| 5-Propargylamino-ddUTP - 6-FAM | 5-Propargylamino-ddUTP - 6-FAM, a fluorescently labeled nucleotide analog, serves as a valuable tool in bioassays for detection of DNA synthesis and repair pathways. Its immense potential in the detection of mutations associated with cancer and other genetic disorders has sparked widespread interest across the scientific community. Furthermore, it can be judiciously administered as a substrate for reverse transcriptases and RNA polymerases. The generated fluorescently labeled cDNA and RNA can then be utilized in RNA labeling or microarray analysis, making it an indispensable component of molecular biology research. Synonyms: 5-Propargylamino-2',3'-dideoxyuridine-5'-triphosphate, labeled with 6 FAM, Triethylammonium salt. Grade: ≥ 95% by HPLC. Molecular formula: C33H28N3O19P3 (free acid). Mole weight: 863.15 (free acid). | |
| 6-FAM | 6-FAM (6-Carboxyfluorescein) is an isomer of carboxyfluorescein and is mainly used for sequencing and labeling of nucleic acids. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: 6-Carboxyfluorescein. CAS No. 3301-79-9. Pack Sizes: 25 mg; 100 mg; 500 mg. Product ID: HY-66021. | |
| 6-FAM-11-dCTP | 6-FAM-11-dCTP, a modified nucleotide employed in molecular biology experimentation, is a highly sought-after material for labeling DNA and RNA. Its employment is particularly useful in fluorescence in situ hybridization (FISH) and DNA sequencing. With use in DNA probe labeling, 6-FAM-11-dCTP is of interest in the detection of genes and mutations linked to diseases including genetic disorders and cancer. Synonyms: 5-[3-(6-(fluoresceinyl-6-carboxamido)hexanoylamido)-propenyl]-2'-deoxycytidine-5'-triphosphate, triethylammonium or tetralithium (optional) salt. Grade: ≥ 95%. | |
| 6-FAM-11-dUTP | 6-FAM-11-dUTP is a highly sought-after fluorescent nucleotide derivative in the field of compound research, employed as a distinguished probe. It bestows the ability to proficiently label DNA and RNA fragments within versatile frameworks like DNA sequencing, PCR compound labeling and even in situ hybridization. Consequently, this exceptional compound unfailingly facilitates the visualization and detection of nucleic acids, thereby cementing its worthiness as an indispensable tool in both molecular biology and diagnostics. Synonyms: 5-[3-(6-(fluoresceinyl-6-carboxamido)hexanoylamido)-propenyl]-2'-deoxyuridine-5'-triphosphate, triethylammonium or tetralithium (optional) salt. Grade: ≥ 95%. | |
| 6-FAM-11-UTP | 6-FAM-11-UTP is a fluorescent nucleotide analog, possessing the ability to be seamlessly integrated into RNA during the transcription process. This unique characteristic facilitates the visual exploration and identification of RNA molecules, empowering researchers to unravel the intricate workings of these vital biomolecules. Its diverse applications encompass a wide range of studies such as transcriptional investigations, RNA labeling endeavors and the real-time tracking of mRNA research and development. Synonyms: 5-[3-(6-(fluoresceinyl-6-carboxamido)hexanoylamido)-propenyl]- uridine-5'-triphosphate, triethylammonium or tetralithium (optional) salt. Grade: ≥ 95%. | |
| 6-Fluorescein dT phosphoramidite | 6-Fluorescein dT phosphoramidite can be inserted into the desired sequence as a replacement for a dT residue during oligonucleotides synthesis. Synonyms: Uridine, 5-[3-[[6-[[[3',6'-bis(2,2-dimethyl-1-oxopropoxy)-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-6-yl]carbonyl]amino]hexyl]amino]-3-oxo-1-propen-1-yl]-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; 5'-Dimethoxytrityloxy-5-[N-((3',6'-dipivaloylfluoresceinyl)-aminohexyl)-3-acrylimido]-2'-deoxyuridine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Fluorescein-dT Phosphoramidite; Fluorescein dT CEP; 6-FAM-dT Phosphoramidite. Grade: ≥95%. CAS No. 1194507-30-6. Molecular formula: C79H89N6O17P. Mole weight: 1425.56. | |
| 6-SFX SE | 6-SFX SE. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 6-FAM-X SE , Fluorescein-6-carboxamidocaproic acid N-succinimidyl ester , 6-(Fluorescein-6-carboxamido)hexanoic acid N-succinimidyl ester. Product Category: Fluorescein Fluorophores. Appearance: Yellow powder. CAS No. 148356-01-8. Molecular formula: C31H26N2O10. Mole weight: 586.55. Purity: 95%+. Product ID: ACM148356018. Alfa Chemistry ISO 9001:2015 Certified. | |
| 7-Propargylamino-7-deaza-ddGTP - 6-FAM | 7-Propargylamino-7-deaza-ddGTP - 6-FAM, a fluorescent nucleotide analog employed in DNA synthesis and sequencing, is incorporated into the DNA strand during DNA replication, rendering specific sequences readily detectable. Moreover, its multifarious uses in biomolecular research and diagnostic assays stem from its remarkable ability to illuminate the intricacies of DNA replication and repair, and the identification of specific cancer biomarkers. Synonyms: 7-Deaza-7-propargylamino-2',3'-dideoxyguanosine-5'-triphosphate, labeled with 6 FAM, Triethylammonium salt. Grade: ≥ 95% by HPLC. Molecular formula: C35H30N5O18P3 (free acid). Mole weight: 901.56 (free acid). | |
| 7-Propargylamino-7-deaza-dGTP - 6-FAM | 7-Propargylamino-7-deaza-dGTP - 6-FAM is an indispensable compound, serving as a powerful instrument for the investigation of intricate DNA repair mechanisms. Esteemed for its capability to act as a luminous probe, this novel probe facilitates the identification and labeling of nucleotides during DNA amplification and sequencing endeavors. Synonyms: 7-Deaza-7-propargylamino-2'-deoxyguanosine-5'-triphosphate, labeled with 6 FAM, Triethylammonium salt. Grade: ≥ 95% by HPLC. Molecular formula: C35H30N5O19P3 (free acid). Mole weight: 917.56 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-adenosine-3',5'-bisphosphate - 6-FAM | 8-[(6-Amino)hexyl]-amino-adenosine-3',5'-bisphosphate - 6-FAM is a fluorescently-labeled derivative of adenosine-3',5'-bisphosphate, a signaling molecule and second messenger within cells. This product is used in biomedical research to study the regulation of intracellular signaling pathways involving adenylate cyclase and phosphodiesterases. It can also be used to investigate nucleotide metabolism and the role of adenylyl cyclases in diseases such as cardiac and neurological disorders. Synonyms: 8-[(6-Amino)hexyl]-amino-adenosine-3',5'-bisphosphate, labeled with 6 FAM, Triethylammonium salt. Grade: ≥ 95% by HPLC. Molecular formula: C37H39N7O16P2 (free acid). Mole weight: 899.70 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-cAMP - 5-FAM | 8-[(6-Amino)hexyl]-amino-cAMP - 5-FAM is a versatile biomedical compound, serving as an illuminating fluorescent cAMP analog. It can be used to comprehensively explore and decipher intricate cellular signaling pathways and their dynamic interconnections. Synonyms: 8-[(6-Amino)hexyl]-amino-adenosine-3',5'-cyclic monophosphate, labeled with 5 FAM, Triethylammonium salt. Grade: ≥ 95% by HPLC. Molecular formula: C37H36N7O12P (free acid). Mole weight: 801.70 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-cAMP - 6-FAM | 8-[(6-Amino)hexyl]-amino-cAMP - 6-FAM is a fluorescently-labeled derivative of cAMP that serves as an important tool for studying cAMP signaling pathways and drug discovery for diseases related to altered cAMP signaling, such as cardiovascular diseases, asthma, and cancer. Synonyms: 8-[(6-Amino)hexyl]-amino-adenosine-3',5'-cyclic monophosphate, labeled with 6 FAM, Triethylammonium salt. Grade: ≥ 95% by HPLC. Molecular formula: C37H36N7O12P (free acid). Mole weight: 801.70 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-GMP - 6-FAM | 8-[(6-Amino)hexyl]-amino-GMP - 6-FAM, a fluorescently-labeled nucleotide analog, is an extensively employed molecule in the field of biomedicine for observing DNA replication and repair, along with mRNA transcription. Furthermore, this molecule serves as an essential diagnostic tool for diseases like cancer and viral infections. Its versatile applications in various fields render it a highly sought-after compound. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-5'-monophosphate, labeled with 6 FAM, Triethylammonium salt. Grade: ≥ 95% by HPLC. Molecular formula: C37H38N7O14P (free acid). Mole weight: 835.72 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-GTP - 6-FAM | 8-[(6-Amino)hexyl]-amino-GTP - 6-FAM is a compound with remarkable bioactivity serving as a fluorescent probe within nucleotide analogs. It facilitates the elucidation and monitoring of G-proteins and their intricate interplays in sundry physiological phenomena. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-5'-triphosphate, labeled with 6 FAM, Triethylammonium salt. Grade: ≥ 95% by HPLC. Molecular formula: C37H40N7O20P3 (free acid). Mole weight: 995.68 (free acid). | |
| AC710 Mesylate | AC710 Mesylate is a potent, selective PDGFR-family kinases inhibitor with Kd values of 0.6 nM/1.0 nM/1.3 nM/1.0 nM for FLT3/KIT/PDGFRα/PDGFRβ respectively. Synonyms: AC710 Mesylate; AC 710 Mesylate; AC-710 Mesylate. Grade: >98%. CAS No. 1351522-05-8. Molecular formula: C32H46N6O7S. Mole weight: 658.81. | |
| Aminoallyl-UTP - 6-FAM | Aminoallyl-UTP - 6-FAM serves as a game-changing tool in molecular biology for the labeling of RNA with fluorescent dyes. Incorporating itself seamlessly into RNA by T7, SP6 or T3 RNA polymerases, it has expansive usage, catering to a niche demand of detecting RNA expression levels in vitro. Gene expression studies, RNA interference research, and drug discovery for assorted diseases including cancers, neurodegenerative disorders, and infectious diseases are areas where Aminoallyl-UTP - 6-FAM shows true prowess. Synonyms: 5-(3-Aminoallyl)-uridine-5'-triphosphate, labeled with 6 FAM, Triethylammonium salt. Grade: ≥ 95% by HPLC. Molecular formula: C33H30N3O21P3 (free acid). Mole weight: 897.52 (free acid). | |
| EDA-GTPγS - 6-FAM | EDA-GTPγS - 6-FAM is an immensely valuable fluorescently labeled compound functioning as a revolutionary tool for the comprehensive investigation of G-protein coupled receptor (GPCR) signaling pathways. By providing real-time monitoring and in-depth analysis, it serves as an indispensable aid in the diligent exploration of pharmaceutical compounds and diseases intricately associated with the cascades of GPCR signaling. Synonyms: 2'/3'-O-(2-Aminoethyl-carbamoyl)-guanosine-5'-(γ-thio)-triphosphate, labeled with 6 FAM, Triethylammonium salt. Grade: ≥ 90 % by HPLC, contains approx. 5 % EDA-GDP-dye. Molecular formula: C34H32N7O20P3S (free acid). Mole weight: 983.64 (free acid). | |
| EDA-m7GTP - 6-FAM | EDA-m7GTP - 6-FAM, a fluorescently labeled nucleotide analog, possesses a paramount binding affinity for the cap structure of messenger RNA, and as such, can be employed in studying the multifarious interactions that underpin RNA capping. Its varied applications include serving as a powerful tool in assessing capping enzyme activity as well as being an instrumental component of various fluorescence-based assays that screen the efficacy of compounds in inhibiting capping enzymes or recapitulating cap binding. Synonyms: 2'/3'-O-(2-Aminoethyl-carbamoyl)-7-methyl-guanosine-5'-triphosphate, labeled with 6 FAM, Triethylammonium salt. Grade: ≥ 95 % by HPLC. Molecular formula: C35H34N7O21P3(free acid). Mole weight: 981.61 (free acid). | |
| Z-VAD-FMK (Cell permeable) | Cell-permeable, non-selective broad-spectrum caspase inhibitor. Binds irreversibly to the catalytic site of caspase proteases. The peptide is O-methylated in the P1 position on aspartic acid, providing enhanced stability and increased cell permeability. Inhibits ICE-family protease/caspase processing, leading to apoptosis and autophagy induction. Decreases proteasome activity. Potent inhibitor of caspase-1 activation in NLRP3-induced cells. Used in apoptosis and inflammasome studies. Group: Biochemicals. Grades: Highly Purified. CAS No. 187389-52-2, 634911-81-2. Pack Sizes: 1mg, 5mg. Molecular Formula: C22H30FN3O7. US Biological Life Sciences. | Worldwide |
| 1,2,3,4,6-Penta-O-benzoyl-b-D-mannopyranose | 1,2,3,4,6-Penta-O-benzoyl-b-D-mannopyranose is a compound succinctly hailing from the expansive carbohydrate derivative family. It is used to delve into the construction of antiviral armaments such as Zanamivir, seamlessly merging with other components. Synonyms: 1,2,3,4,6-Penta-O-benzoyl-beta-D-mannopyranose; (2S,3S,4S,5R,6R)-6-((Benzoyloxy)methyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetrabenzoate. CAS No. 13526-09-5. Molecular formula: C41H32O11. Mole weight: 700.69. | |
| (-)-1,2-Bis((2R,5R)-2,5-dimethylphospholano)benzene(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate, 98+% (R,R)-Me-DUPHOS-Rh | (-)-1,2-Bis((2R,5R)-2,5-dimethylphospholano)benzene(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate, 98+% (R,R)-Me-DUPHOS-Rh. Uses: The duphos family of catalysts is highly efficient for the asymmetric hydrogenation of various substituted acetamidoacrylates and enol acetates yielding products of high enantiomeric excesses. efficient ligand for the asymmetric hydrogenation of tetrasubstituted enamides. forms superior catalysts for asymmetric reductive aminations. catalyst used for the asymmetric hydrogenation of enol phosphon. Additional or Alternative Names: 210057-23-1;MFCD01862466;057B231;(-)-1,2-Bis[(2R,5R)-dimethylphospholano]benzene(cyclooCtadiene)rhodium(I) tetrafluoroborate;1,2-Bis[(2R,5R)-2,5-dimethylphospholano]benzene(cyclooctadiene)rhodium(I)tetrafluoroborate;(-)-1,2-Bis((2R,5R)-2,5-dimethylphospholano)benzene(cyclooctadiene)rhodium (I) tetrafluoroborate;(-)-1,2-Bis((2R,5R)-2,5-dimethylphospholano)benzene(cyclooctadiene)rhodium(I) tetrafluo. Product Category: Rhodium series of catalysts. CAS No. 210057-23-1. Molecular formula: C26H40BF4P2Rh-. Mole weight: 604.263g/mol. IUPACName: cycloocta-1,5-diene;(2R,5R)-1-[2-[(2R,5R)-2,5-dimethylphospholan-1-yl]phenyl]-2,5-dimethylphospholane;rhodium;tetrafluoroborate. Canonical SMILES: [B-](F)(F)(F)F.CC1CCC(P1C2=CC=CC=C2P3C(CCC3C)C)C.C1CC=CCCC=C1.[Rh]. ECNumber: 446 | |
| (+)-1,2-Bis((2S,5S)-2,5-dimethylphospholano)benzene(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate, 98+% (S,S)-Me-DUPHOS-Rh | (+)-1,2-Bis((2S,5S)-2,5-dimethylphospholano)benzene(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate, 98+% (S,S)-Me-DUPHOS-Rh. Uses: The duphos family of catalysts is highly efficient for the asymmetric hydrogenation of various substituted acetamidoacrylates and enol acetates yielding products of high enantiomeric excesses. efficient ligand for the asymmetric hydrogenation of tetrasubstituted enamides. forms superior catalysts for asymmetric reductive aminations. catalyst used for the asymmetric hydrogenation of enol phosphon. Additional or Alternative Names: (+)-1,2-Bis((2S,5S)-2,5-dimethylphospholano)benzene(cyclooctadiene)Rh(I)tetrafluoroborate; (2R,5R)-1-[2-[(2R,5R)-2,5-dimethylphospholan-1-yl]phenyl]-2,5-dimethylphospholane; MFCD01862467; 205064-10-4; AC1MC1E8. Product Category: Rhodium series of catalysts. CAS No. 205064-10-4. Molecular formula: C26H40BF4P2Rh-. Mole weight: 604.263g/mol. IUPACName: cycloocta-1,5-diene;(2S,5S)-1-[2-[(2S,5S)-2,5-dimethylphospholan-1-yl]phenyl]-2,5-dimethylphospholane;rhodium;tetrafluoroborate. Canonical SMILES: [B-](F)(F)(F)F.CC1CCC(P1C2=CC=CC=C2P3C(CCC3C)C)C.C1CC=CCCC=C1.[Rh]. Product ID: ACM205064104. Alfa Chemistry ISO 9001:2015 Certified. | |
| 1,4,5,8-Naphthalenetetracarboxylic dianhydride | Napthalenetetracarboxylic dianhydride is an organic compound related to naphthalene. The compound is a beige solid. NTDAs are most commonly used as a precursor to naphthalenediimides (NDIs), a family of compound with many different uses. Uses: Ntcda can be used in the fabrication of a variety of devices such as fuel cells, thin film transistors (otfts), lithium ion batteries, and organic photovoltaics (opv). an n-channel organic semiconductor. Group: Organic field effect transistor (ofet) materials. Alternative Names: [2]Benzopyrano[6,5,4-def][2]benzopyran-1,3,6,8-tetrone; NTCDA. CAS No. 81-30-1. Pack Sizes: Packaging 5, 25, 100 g in glass bottle. Product ID: 6, 13-dioxatetracyclo[6.6.2.04, 16.011, 15]hexadeca-1(15), 2, 4(16), 8, 10-pentaene-5, 7, 12, 14-tetrone. Molecular formula: 268.18. Mole weight: C14H4O6. O=C1OC (=O)c2ccc3C (=O)OC (=O)c4ccc1c2c34. 1S/C14H4O6/c15-11-5-1-2-6-10-8 (14 (18)20-12 (6)16)4-3-7 (9 (5)10)13 (17)19-11/h1-4H. YTVNOVQHSGMMOV-UHFFFAOYSA-N. |  |
| 1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming) | This enzyme is present in some but not all Rhizobium species and belongs in the GFO/IDH/MocA protein family. This enzyme differs from hepatic 1,5-anhydro-D-fructose reductase, which yields 1,5-anhydro-D-glucitol as the product (see EC 1.1.1.263). In Sinorhizobium morelense, the product of the reaction, 1,5-anhydro-D-mannitol, can be further metabolized to D-mannose. The enzyme also reduces 1,5-anhydro-D-erythro-hexo-2,3-diulose and 2-ketoaldoses (called osones), such as D-glucosone (D-arabino-hexos-2-ulose) and 6-deoxy-D-glucosone. It does not reduce common aldoses and ketoses, or non-sugar aldehydes and ketones. Group: Enzymes. Synonyms: 1,5-anhydro-D-fructose reductase (ambiguous); AFR. Enzyme Commission Number: EC 1.1.1.292. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0201; 1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming); EC 1.1.1.292; 1,5-anhydro-D-fructose reductase (ambiguous); AFR. Cat No: EXWM-0201. |  |
| 2-β-D-Glucopyranosyloxy-4-hydroxy-1,4-benzoxazin-3-one | 2-β-D-Glucopyranosyloxy-4-hydroxy-1,4-benzoxazin-3-one, also known as DIBOA-Glc, is a benzoxazinone compound found in certain plants, particularly in the Poaceae family, such as rye (Secale cereale). This compound plays a role in plant defense mechanisms, acting as a natural pesticide and allelopathic agent that can inhibit the growth of other plants. It has also been studied for its potential health benefits, including its absorption and metabolic fate in the human body after consumption of high- and low-benzoxazinoid diets. DIBOA-Glc and its oxidized analog, HBOA-Glc, have been identified as compounds present in the roots of Eastern gamagrass (Tripsacum dactyloides), suggesting that they may have applications in sustainable weed control and organic farming. Additionally, research has shown that DIBOA-Glc can be absorbed and metabolized in the body, indicating potential bioactivity and health implications. Synonyms: 2-(β-D-Glucopyranosyloxy)-4-hydroxy-2H-1,4-benzoxazin-3(4H)-one; 2-(2,4-Dihydroxy-1,4(2H)-benzoxazin-3(4H)-one)-β-D-glucopyranoside; DIBOA-Glc; 2-[(2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy]-4-hydroxy-2,4-dihydro-1,4-benzoxazin-3-one; 2-beta-D-Glucopyranosyloxy-4-hydroxy-1,4-benzoxazin-3-one; DIBOA-beta-D-glucoside. Grade: ≥95%. CAS No. 22260-47-5. Molecular formula: C14H17NO9. Mole weight: 343.29. | |
| 5-dehydro-2-deoxyphosphogluconate aldolase | This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. Group: Enzymes. Synonyms: phospho-5-keto-2-deoxygluconate aldolase; 5-dehydro-2-deoxy-D-gluconate-6-phosphate malonate-semialdehyde-lyase. Enzyme Commission Number: EC 4.1.2.29. CAS No. 62213-25-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4868; 5-dehydro-2-deoxyphosphogluconate aldolase; EC 4.1.2.29; 62213-25-6; phospho-5-keto-2-deoxygluconate aldolase; 5-dehydro-2-deoxy-D-gluconate-6-phosphate malonate-semialdehyde-lyase. Cat No: EXWM-4868. | |
| 6-Chloro-5-(2,3-dichlorophenoxy)-2-methylthio-benzimidazole (Triclabendazole) | Triclabendazole is a member of the benzimidazole family of anthelmintics. It is effective against F. hepatica helminths that cause fascioliasis, reducing secreted protease enzyme activities that are critical for the invasion, migration, nutrition, and survival of the parasite.1 In yeast and mammalian cells, triclabendazole was shown to inhibit adenylyl cyclase in the Ras-adenylyl cyclase-protein kinase A nutrient-sensing pathway and to prevent apoptosis induced by the Parkinsons disease-related protein α-synuclein, demonstrating a protective role during various cellular stresses.2,3. Group: Biochemicals. Alternative Names: 5-Chloro-6- (2, 3-dichlorophenoxy) -2- methyl thiobenzimidazole; CGA-89317, egaten; Fasinex; Triclabendazole. Grades: Highly Purified. CAS No. 68786-66-3. Pack Sizes: 25g, 50g, 100g. Molecular Formula: C14H9Cl3N2OS, Molecular Weight: 359.66. US Biological Life Sciences. | Worldwide |
| 7-Propargylamino-7-deaza-ddATP - 6-FAM | 7-Propargylamino-7-deaza-ddATP is a fluorescently-labeled nucleotide used in biomedical research for various applications, including DNA sequencing, gene expression analysis and drug development. This compound is incorporated into DNA molecules during amplification or development reactions to enable detection and visualization using fluorescence-based techniques like fluorescence resonance energy transfer (FRET) or fluorescence in situ hybridization (FISH). It is commonly used in the study of DNA-protein interactions, nucleotide modifications and DNA repair mechanisms. Synonyms: 7-Deaza-7-propargylamino-2',3'-dideoxyadenosine-5'-triphosphate, labeled with 6 FAM, Triethylammonium salt. Grade: ≥ 95% by HPLC. Molecular formula: C35H30N5O17P3 (free acid). Mole weight: 885.56 (free acid). | |
| 7-Propargylamino-7-deaza-dGTP - ATTO-612Q | 7-Propargylamino-7-deaza-dGTP - ATTO-612Q, a fluorescent nucleotide analog famous among the scientific community, is a quintessential biomolecular research tool suitable for comprehensive labeling of DNA and RNA. By implementing it in various PCR and sequencing applications, ATTO-612Q helps researchers to identify individual labeled nucleotides in DNA sequences. Besides this, it also helps in analyzing DNA-protein interactions, thereby aiding inspective drug targeting strategies for various diseases like infectious diseases and cancer. Synonyms: 7-Deaza-7-propargylamino-2'-deoxyguanosine-5'-triphosphate, labeled with ATTO 612Q, Triethylammonium salt. Grade: ≥ 95% by HPLC. Molecular formula: C14H20N5O13P3- ATTO 612Q (free acid). Mole weight: 1231.25 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-GTP - ATTO-550 | 8-[(6-Amino)hexyl]-amino-GTP - ATTO-550, a fluorescent probe, intricately investigates the behavior of GTP-binding proteins. Its high level of purity distinguishes it, as it magnifies detection and monitoring of the activities of GTP-binding proteins such as Ras, Rho, and Rab family proteins. Additionally, it serves to track cell signaling pathways and evaluate the response of drugs for diseases, including but not limited to cancer, cardiovascular, and neurological disorders. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-5'-triphosphate, labeled with ATTO 550, Triethylammonium salt. Grade: ≥ 95% by HPLC. Molecular formula: C16H30N7O14P3- ATTO 550 (free acid). Mole weight: 1212.37 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-GTP - Biotin | 8-[(6-Amino)hexyl]-amino-GTP - Biotin, a biochemical product, finds its application in exploring cell signaling pathways and G protein-coupled receptor (GPCR) signaling. Besides working as a probe for GTPases, it serves as a substrate for enzymatic assays to track G-protein activation or GTP concentration in cells. Also, it is a famous material for affinity purification, allowing researchers to isolate target proteins during chromatography. Overall, this versatile compound amplifies the scope of cell biology-related inquiries in both academia and industry. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-5'-triphosphate - Biotin, Triethylammonium salt. Grade: ≥ 95% by HPLC. Molecular formula: C26H44N9O16P3S (free acid). Mole weight: 863.66 (free acid). | |
| A-770041 | A-770041 is an selective and orally bioavailable pyrazolo[3,4-d]pyrimidine exhibiting selectivity for Lck compared with previously reported compounds. It is 300-fold selective against Fyn, the other Src family kinase involved in T-cell signaling. It is currently in the preclinical developlent stage and no clinical data are available. Synonyms: A-770041; A 770041; A770041. Grade: >98%. CAS No. 869748-10-7. Molecular formula: C34H39N9O3. Mole weight: 621.73. | |
| Akt1 and Akt2-IN-1 | Akt1 and Akt2-IN-1 is an allosteric inhibitor of Akt1 and Akt2 with the IC50 of 3.5 nM and 42 nM respectively. It has potent and balanced activity. It is dependent on the PH-domain for Akt inhibition. It is selective for Akt1/2 over Akt3 and is highly selective over other members of the AGC family of kinases in vitro. It has potent inhibitory activity against Akt1 and Akt 2 in vivo in a mouse lung and efficacy in a tumor xenograft model. It has moderate activity in an hERG binding assay and is a substrate for human P-glycoprotein. It also shows good physical properties with a human plasma protein binding. Uses: Akt1 and akt2-in-1 has potent inhibitory activity against akt1 and akt 2 and efficacy in a tumor xenograft model. Synonyms: Akt Inhibitor 17; Akti_2008; Akti 2008; Akti2008; Akti-2008; Akt Inhibitor 17; Akt-Inhibitor-17; AktInhibitor17; 3-Phenyl-2-[4-[[4-[5-(2-pyridinyl)-1H-1,2,4-triazol-3-yl]-1-piperidinyl]methyl]phenyl]-1,6-Naphthyridin-5(6H)-one; Akti_2008; 3-phenyl-2-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]-6H-1,6-naphthyridin-5-one. Grade: >98%. CAS No. 893422-47-4. Molecular formula: C33H29N7O. Mole weight: 539.63. | |
| Akt Inhibitor, Isozyme-selective (1,3-Dihydro-1-(1-((4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one; Akti-1/2) | Cell-permeable. A potent and selective inhibitor of Akt1/Akt2 activity (IC?? = 58nM (Akt1), 210nM (Akt2) and 2.12uM (Akt3) in in vitro kinase assays). The inhibition appears to be pleckstrin homology (PH) domain-dependent. It does not exhibit any inhibitory effect against PH domain-lacking Akts, or other closely related AGC family kinases, PKA, PKC, and SGK, even at concentrations (50uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 612847-09-3. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| AKT inhibitor VIII | Akt Inhibitor VIII is a cell-permeable quinoxaline compound that has been shown to potently, selectively, allosterically, and reversibly inhibit Akt1, Akt2, and Akt3 activity. It does not exhibit any inhibitory effect against pleckstrin homology (PH) domain-lacking Akts, AGC family kinases, PKA, PKC or SGK. It also prevails over Akt1/Akt2-mediated resistance to chemotherapeutics in tumor cells and has been shown to block basal and stimulated phosphorylation/activation of Akt1/Akt2 in cultured cells and in mice. Synonyms: AKT inhibitor VIII; AKT-inhibitor-VIII; AKT inhibitor-8; AKT-inhibitor-8; Akt-I 1,2; Akti-1/2. Sigma-A6730. 2H-Benzimidazol-2-one, 1,3-dihydro-1-[1-[[4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl]methyl]-4-piperidinyl]-. Grade: >98%. CAS No. 612847-09-3. Molecular formula: C34H29N7O. Mole weight: 551.64. | |
| Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 (1,3-Dihydro-1-(1-((4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one, Akti-1/2) | A cell-permeable, reversible, potent, and selective inhibitor of Akt1/Akt2 activity (IC50=58nM, 210nM, and 2.12uM for Akt1, Akt2, and Akt3, respectively, in in vitro kinase assays). The inhibition is reported to be pleckstrin homology (PH) domain-dependent. It does not exhibit any inhibitory effect against PH domain-lacking Akts, or other closely related AGC family kinases, PKA, PKC, and SGK, even at concentrations as high as 50uM. Overcomes Akt1/Akt2-mediated resistance to chemotherapeutics in tumor cells and is shown to block basal and stimulated phosphorylation / activation of Akt1/Akt2 both in cultured cells in vitro and in mice in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 612847-09-3. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| Alcohol Dehydrogenase (NADP+ dependent) from E. coli, Recombinant | Alcohol dehydrogenase [NADP+] also known as aldehyde reductase or aldo-keto reductase family 1 member A1 is an enzyme that in humans is encoded by the AKR1A1 gene. This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Alternative splicing of this gene results in two transcript variants encoding the same protein. Group: Enzymes. Synonyms: EC 1.1.1.2; Aromatic Alcohol Dehydrogenase; Alcohol:NADP+ oxidoreductase; AKR1A1; ALDR1; ALR; . Enzyme Commission Number: EC 1.1.1.2. CAS No. 9028-12-0. ALR. Activity: >500 U/ml. Form: Liquid. Source: E. coli. Species: E. coli. EC 1.1.1.2; Aromatic Alcohol Dehydrogenase; Alcohol:NADP+ oxidoreductase; AKR1A1; ALDR1; ALR; ARM; DD3; HEL-S-6; aldehyde reductase; aldo-keto reductase family 1 member A1; alcohol dehydrogenase (NADP+); aldehyde reductase (NADPH2); NADP-alcohol dehydrogenase; NADP+-aldehyde reductase; NADP+-dependent aldehyde reductase; NADPH-aldehyde reductase; NADPH-dependent aldehyde reductase; nonspecific succinic semialdehyde reductase; ALR 1; low-Km aldehyde reductase; high-Km aldehyde reductase; alcohol dehydrogenase (NADP). Cat No: NATE-1589. | |
| Alcohol Dehydrogenase (NADP+ dependent) from Entamoeba species, Recombinant | NADP-dependent isopropanol dehydrogenase belongs to the superfamily of alcohol dehydrogenases with a preference for medium chain secondary alcohols, such as 2- butanol and isopropanol, while it has low activity with primary alcohols, such as ethanol. Under physiological conditions, the enzyme reduces aldehydes and 2-ketones to produce secondary alcohols. It is also active with acetaldehyde and propionaldehyde. Group: Enzymes. Synonyms: EC 1.1.1.2; Aromatic Alcohol Dehy. Purity: > 95% by SDS-PAGE. ALR. Mole weight: ~40.9 kDa (SDS-PAGE). Activity: > 60U/mg. Storage: Aliquot and store at -20°C. Avoid repeated freeze thaw cycles. Form: Liquid, 1 mg/mL solution in 50 mM Tris-HCl buffer (pH 8.0) containing 100 mM NaCl and 50% glycerol. Source: E. coli. Species: Entamoeba species. EC 1.1.1.2; Aromatic Alcohol Dehydrogenase; Alcohol:NADP+ oxidoreductase; AKR1A1; ALDR1; ALR; ARM; DD3; HEL-S-6; aldehyde reductase; aldo-keto reductase family 1 member A1; alcohol dehydrogenase (NADP+); aldehyde reductase (NADPH2); NADP-alcohol dehydrogenase; NADP+-aldehyde reductase; NADP+-dependent aldehyde reductase; NADPH-aldehyde reductase; NADPH-dependent aldehyde reductase; nonspecific succinic semialdehyde reductase; ALR 1; low-Km aldehyde reductase; high-Km aldehyde reductase; alcohol dehydrogenase (NADP). Cat No: NATE-1590. | |
| Ampicillin sodium | Ampicillin is a beta-lactam antibiotic that is a part of the aminopenicillin family. It is mainly used for infections and sepsis of the lungs, intestines, biliary tract, urinary tract caused by sensitive bacteria. Synonyms: D-(-)-6-(2-Amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid Monosodium Salt; [2S-[2α,5α,6β(S*)]]-6-[(Aminophenylacetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid Monosodium Salt; (2S,5R,6R)-6-[[(2R)-Aminophenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid Monosodium Salt; Alpen N; Amcill S; Ampi-Dry 5000; Ampicillin Sodium; Ampicillin Sodium Salt; Ampicillin-Na; Ampicin; Anhypen; Binotal Sodium; Britapen Injection; Cilleral; D-α-Aminobenzylpenicillin Sodium Salt; Monosodium Ampicillin; Omnipen N; Pamecil; Pen A/N; Penbritin S; Pentrex; Polycillin N; Principen N; Sodium 6-(2-Amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate; Benzylpenicillin Sodium; Amcill-S; Ampicillin natrium. Grade: 97%. CAS No. 69-52-3. Molecular formula: C16H18N3NaO4S. Mole weight: 371.39. | |
| ARQ 531 | ARQ-531 is a potent and orally active BTK inhibitor with potential antineoplastic activity. ARQ 531 is a reversible non-covalent inhibitor of Bruton's Tyrosine Kinase (BTK), with IC50s of 0.85 nM and 0.39 nM for WT-BTK and C481S-BTK, respectively. It also has a distinct kinase selectivity profile with strong inhibitory activity against several key oncogenic drivers from TEC, Trk and Src family kinases. In GCB-DLBCL cell lines (SUDHL-4 and DOHH-2), ARQ 531 potently suppressed expression of anti-apoptotic c-Myc and BCL6 oncoproteins in a dose-dependent fashion, and concomitantly induced apoptotic cleavage of PARP protein. Synonyms: ARQ-531. Grade: ≥98%. CAS No. 2095393-15-8. Molecular formula: C25H23ClN4O4. Mole weight: 478.93. | |
| Aurora Kinase A active human, Recombinant | Aurora A kinase also known as serine/threonine-protein kinase 6 is an enzyme that in humans is encoded by the AURKA gene. Aurora A is a member of a family of mitotic serine/threonine kinases. It is implicated with important processes during mitosis and meiosis whose proper function is integral for healthy cell proliferation. Aurora A is activated by one or more phosphorylations and its activity peaks during the G2 phase to M phase transition in the cell cycle. Human aurora kinase a (genbank accession no. nm_003600), amino acids 2-403 with n-terminal his6-tag, mw=50 kda, expressed in a baculovirus infected sf9 cell expression system. Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. Group: Enzymes. Synonyms: Aurora Kinase A; Aurora A kinase; serine/threonine-protein kinase 6; AURKA; AIK; ARK1; AURA; AURORA2; BTAK; PPP1R47; STK15; STK6; STK7. Purity: > 90% (SDS-PAGE). ARK1. Mole weight: mol wt 50 kDa. Activity: ~17,000 units/mg protein. Form: aqueous solution. Source: baculovirus infected Sf9 cells. Species: Human. Aurora Kinase A; Aurora A kinase; serine/threonine-protein kinase 6; AURKA; AIK; ARK1; AURA; AURORA2; BTAK; PPP1R47; STK15; STK6; STK7. Pack: Minimum 50 ng protein/vial by Bradford. Cat No: NATE-0087. | |
| AZ191 | AZ191 is a cell-permeable azaindole that inhibits the serine/threonine kinase activity of DYRK1B (IC50 = 17 nM) with 5-fold and 110-fold selectivity against the related family members DYRK1A and DYRK2, respectively. Synonyms: AZ191; AZ 191; AZ-191. Grade: >98%. CAS No. 1594092-37-1. Molecular formula: C24H27N7O. Mole weight: 429.52. | |
| AZ6102 | AZ6102 is a moderate oral bioavailable dual inhibitor of TNKS1/2 with excellent selectivity against other PARP family enzymes including PARP-1, PARP-2 and PARP-6. It also inhibits Wnt signaling in DLD-1 cells. IC50: TNKS2= 1 nM; TNKS1= 3 nM; Wnt signaling. Synonyms: 2-[4-[6-[(3S,5R)-3,5-dimethylpiperazin-1-yl]-4-methylpyridin-3-yl]phenyl]-7-methyl-1H-pyrrolo[2,3-d]pyrimidin-4-oneAZ6102; AZ-6102; AZ 6102.AZ 6102|rel-2-[4-[6-[(3R,5S)-3,5-Dimethyl-1-piperazinyl]-4-methyl-3-pyridinyl]phenyl]-3,7-dihydro-7-methyl-4H-pyrrolo[2,3-d]pyrimidi. CAS No. 1645286-75-4. Molecular formula: C25H28N6O. Mole weight: 428.53. | |
| AZ82 | AZ82 is a kinesin-14 family protein that is important for assembling bipolar spindles in cancer cells containing supernumerary centrosomes. AZ82 is a selective kinesin-like protein HSET inhibitor with Ki of 43 nM and KIFC1 inhibitor with IC50 of 300 nM. It shows microtubule-noncompetitive manner but does not inhibit basal KIFC1 activity at a concentration of 100 μM. In Vitro, AZ82 is shown to specifically induce multipolar spindles in BT-549 cells, but not in cancer cells with normal centrosome number, such as HeLa. Synonyms: AZ-82; AZ 82. Grade: ≥98%. CAS No. 1449578-65-7. Molecular formula: C28H31F3N4O3S. Mole weight: 560.6. | |
| AZD5305 | AZD5305 is a potent, selective and oral active PARP inhibitor. AZD5305 is a highly potent inhibitor of PARP1, with significant PARP1-DNA trapping activity, no PARP2-activity, nor binding activity to any other members of the PARP family. AZD5305 has excellent secondary pharmacology and physicochemical properties as well as high oral bioavailability in preclinical species. Uses: Designed for use in research and industrial production. Additional or Alternative Names: AZD5305; AZD-5305; AZD 5305. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2589531-76-8. Molecular formula: C22H26N6O2. Mole weight: 406.49. Purity: >98%. IUPACName: 5-(4-((7-ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl)piperazin-1-yl)-N-methylpicolinamide. Canonical SMILES: O=C(C1=NC=C(N2CCN(CC3=CC(N4)=C(N=C3)C=C(CC)C4=O)CC2)C=C1)NC. Product ID: ACM2589531768. Alfa Chemistry ISO 9001:2015 Certified. Categories: AZD1305. | |
| BAY 299 | BAY 299 is a potent and selective inhibitor of BRD1 and TAF1 (IC50 = 6-67 and 8-13 nM, respectively) with selectivity over other bromodomains (>30-fold over other members of the BRPF family; BRD9 and ATAD2; >300-fold over BRD4). BAY 299 suppresses binding of BRD1 and TAF1 to histone H4 (IC50 = 575 nM and 0.9 μM, respectively) and histone H3.3 (IC50 = 825 nM and 1.4 μM, respectively). Synonyms: BAY-299; BAY 299; BAY299. 6-(3-Hydroxypropyl)-2-(1,3,6-trimethyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)-1H-benzo[de]isoquinoline-1,3(2H)-dione. Grade: ≥98% by HPLC. CAS No. 2080306-23-4. Molecular formula: C25H23N3O4. Mole weight: 429.47. | |
| beta-Zearalanol | It is a minor analogue of the zearalenone family of resorcinyl macrocyclic lactones produced by several species of fusarium. It exhibits estrogenic activity in animals and is a growth promotant for animals. Synonyms: Taleranol; β-Zearanol; β-Zeranol; 1H-2-Benzoxacyclotetradecin-1-one, 3,4,5,6,7,8,9,10,11,12-decahydro-7,14,16-trihydroxy-3-methyl-, (3S-(3R*,7R*))-; P 1560. Grade: >99% by HPLC. CAS No. 42422-68-4. Molecular formula: C18H26O5. Mole weight: 322.40. | |
| BI 01383298 | BI01383298 is a potent and selective inhibitor of human SLC13A5 (Na+/citrate co-transporter) with IC50 of 56 nM in HEK cells overexpressing hSLC13A5. BI01383298 is highly selective over other family members and other transporters with >1000-fold selectivity over others. Synonyms: 1-[(3,5-Dichlorophenyl)sulfonyl]-N-[(4-fluorophenyl)methyl]-4-piperidinecarboxamide. Grade: ≥98%. CAS No. 2227549-00-8. Molecular formula: C19H19Cl2FN2O3S. Mole weight: 445.34. | |
| BLU9931 | BLU9931 is a potent and irreversible small-molecule inhibitor of FGFR4, as a targeted therapy to treat patients with HCC whose tumors have an activated FGFR4 signaling pathway. BLU9931 is exquisitely selective for FGFR4 versus other FGFR family members and all other kinases. Synonyms: BLU9931; BLU-9931; BLU 9931. Grade: 98%. CAS No. 1538604-68-0. Molecular formula: C26H22Cl2N4O3. Mole weight: 509.38. | |
| BMS-935177 | BMS-935177 is a potent and selective reversible inhibitor of Bruton's tyrosine kinase (BTK) with an IC50 of 3 nM and demonstrates good kinase selectivity. It is more potent against BTK than other kinase, including the other Tec family kinases (TEC, BMX, ITK, and TXK) over which the compound is between 5- and 67-fold selective. BMS-935177 inhibited calcium flux in human Ramos B cells with IC50 of 27 nM and inhibited CD69 surface expression in peripheral B cells stimulated with anti-IgM and anti-IgG. Synonyms: BMS-935177; BMS935177. Grade: ≥98%. CAS No. 1231889-53-4. Molecular formula: C31H26N4O3. Mole weight: 502.56. | |
| BMS-986142 | Bruton's tyrosine kinase (BTK) is a nonreceptor tyrosine kinase. It is a member of the Tec family of kinases. BTK plays an essential role in B cell receptor (BCR)-mediated signaling as well as Fcγ receptor signaling in monocytes and Fcε receptor signaling. BMS-986142 is a potent, selective and reversible BTK inhibitor with IC50 of 0.5 nM. It potently inhibits BCR-stimulated expression of CD69 on B cells in human whole blood with IC50 of 90 nM. Synonyms: BMS-986142; BMS986142. Grade: ≥98%. CAS No. 1643368-58-4. Molecular formula: C32H30F2N4O4. Mole weight: 572.60. | |
| BMX-IN-1 | A cell-permeable tricyclic quinoline-acrylamide compound that potently inhibits BMX and BTK kinase activity (IC50 = 8 and 10.4nM, respectively) by covalently targeting ATP-binding site cysteine, while being less potent against TEC family kinases TEC, JAK3, BLK with the same conserved cysteine (IC50 = 175, 377, and 653nM, respectively). Only PI 3-K gamma/PIK3CG, SBK1, PIP5K2C (by ≥94% at 1uM), and TXK (by 75% at 1uM) are significantly inhibited by BMX-IN-1 in a selectivity profiling against 437 other kinase constructs. Potently inhibits the proliferation of TEL-BMX transformed Ba/F3 Ba/F3 (GI50 = 25nM), while being much less effective against TEL-BLK, TEL-JAK1, TEL-JAK2, TEL-JAK3, or TEL-TYK2E957D transformed Ba/F3 (GI50 = ≥3.64uM) or a panel of 5 prostate cancer cell lines (GI50 ≥2.46uM). Group: Biochemicals. Alternative Names: N- (2-Methyl-5- (9- (4- (methylsulfonamido) phenyl) -2-oxobenzo[h][1, 6]naphthyridin-1 (2H) -yl) phenyl) acrylamide, BMX/BTK Inhibitor, Bruton's Tyrosine Kinase Inhibitor IV, BLK Inhibitor I, BMX Inhibitor I, JAK3 Inhibitor XIII, PI 3-K Inhibitor XX, PIP5K2C Inhibitor I, SBK1 Inhibitor I, TEC Inhibitor I, TXK Inhibitor I. Grades: Highly Purified. CAS No. 1431525-23-4. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?S. US Biological Life Sciences. | Worldwide |
| BN82002 hydrochloride | BN82002 hydrochloride is a potent, selective and irreversible inhibitor of CDC25 phosphatase family. BN82002 hydrochloride inhibits CDC25A, CDC25B2, CDC25B3, CDC25C CDC25A, and 25C-cat with IC 50 values of 2.4, 3.9, 6.3, 5.4, and 4.6 μM, respectively. BN82002 hydrochloride displays ~20-fold greater selectivity over CD45 tyrosine phosphatase [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1049740-43-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-112776A. | |
| Caspase-6 (Active) from Human, Recombinant | Caspase-6 is an enzyme that in humans is encoded by the CASP6 gene. This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Caspase 6 can also undergo self-processing without other members of the caspase family. Alternative splicing of this gene results in two transcript variants that encode different isoforms. Group: Enzymes. Synonyms: CASP6; MCH2; Caspase-6 (Active); Caspase-6. Caspase 6. Appearance: Liquid. Storage: -80°C. Form: Liquid. 5μg in 25μl of 50mM TRIS (pH 8.0) containing 100mM sodium chloride and 50mM imidazole. Source: E. coli. Species: Human. CASP6; MCH2; Caspase-6 (Active); Caspase-6. Cat No: NATE-0814. | |
| CAY10462 | 20-HETE is an important metabolite of arachidonic acid in the vasculature, especially in the kidney, where it is synthesized by cytochrome P450 (CYP450) enzymes of the 4A family. CAY10462 is the hydrochloride salt form of CAY10434. It is a selective inhibitor of the 20-HETE synthase CYP4A11, which exhibits an IC50 of 8.8 nM when tested in human renal microsomes. Synonyms: CAY 10462; CAY-10462. Grade: ≥98%. CAS No. 502656-68-0. Molecular formula: C17H25N3O·2HCl. Mole weight: 360.3. | |
| CBA | Transient Receptor Potential Cation Channel Subfamily M Member 4 (TRPM 4) is a Protein Coding gene. Diseases associated with TRPM4 include Progressive Familial Heart Block, Type Ib and Erythrokeratodermia Variabilis Et Progressiva. TRPM4-IN-5 is a potent and selective inhibitor of the cation channel TRPM4 blocker with IC 50 of 1.5 μM. Synonyms: 4-Chloro-2-[[2-(2-chlorophenoxy)acetyl]amino]benzoic acid; TRPM4-IN-5; TRPM4IN-5; TRPM4-IN5; TRPM4 IN-5. Grade: ≥98%. CAS No. 351424-20-9. Molecular formula: C15H11Cl2NO4. Mole weight: 340.16. | |
| CDK9-IN-1 | Among CDKs, CDK9 is a validated pathological target in HIV infection, inflammation and cardiac hypertrophy; however selective CDK9 inhibitors are still not available. We present a selective inhibitor family of CDK9 based on the 4-phenylamino-6- phenylpyrimidine nucleus. We show a convenient synthetic method to prepare a useful intermediate and its derivatisation resulting in novel compounds. The CDK9 inhibitory activity of the derivatives was measured in specific kinase assay and the CDK inhibitory profile of the best ones (IC50 > 100nM) was determined. The most selective compounds had high selectivity over CDK1, 2, 3, 5, 6, 7 and showed at least one order of magnitude higher inhibitory activity over CDK4 inhibition. The most selective molecules were examined in cytotoxicity assays and their ability to inhibit HIV-1 replication was determined in cellular assays. Synonyms: CDK9-IN-1; CDK9 IN 1. Grade: >98%. CAS No. 1415559-43-1. Molecular formula: C26H21N5O4S. Mole weight: 499.54. | |
| Cholecalciferol EP Impurity A | 5,6-trans-Vitamin D3 is the major photoisomer of Vitamin D3 analog. Vitamin D3 is a type of vitamin D found to be effective in mediating intestinal calcium absorbtion and bone calcium metabolism. Vitamin D3 is used for the prevention and treatment of vitamin D deficiency and associated disease including rickets, and also used for familial hypophosphatemia, hypoparathyroidism and Fanconi syndrome. Synonyms: (5E,7E)-9,10-secocholesta-5,7,10(19)-trien-3β-ol; trans-cholecalciferol; trans-vitamin D3. Grade: > 95%. CAS No. 22350-41-0. Molecular formula: C27H44O. Mole weight: 384.64. | |
| Citreoviridin | The dominant analogue of a family of tetraene mycotoxins with potent neurotoxic effects, produced by several species of aspergillus and penicillium. It inhibits mitochondrial ATPase and is a causative agent of cardiac beriberi. Synonyms: Citreoviridin A; Citreoviridine; Citreoviridine A; [2S-[2α(1E,3E,5E,7E),3β,4α,5α]]-4-Methoxy-5-methyl-6-[7-methyl-8-(tetrahydro-3,4-dihydroxy-2,4,5-trimethyl-2-furanyl)-1,3,5,7-octatetraenyl]-2H-pyran-2-one; 2,5-Anhydro-1,6-dideoxy-2-C-[(1E,3E,5E,7E)-8-(4-methoxy-5-methyl-2-oxo-2H-pyran-6-yl)-2-methyl-1,3,5,7-octatetraenyl]-4-C-methyl-D-Iditol. Grade: >97% by HPLC. CAS No. 25425-12-1. Molecular formula: C23H30O6. Mole weight: 402.48. | |
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