Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
| Product | Description | |
|---|---|---|
| Abl Kinase Mutant active human, Recombinant | Abelson murine leukemia viral oncogene homolog 1 also known as ABL1 is a protein that, in humans, is encoded by the ABL1 gene (previous symbol ABL) located on chromosome 9. c-Abl is sometimes used to refer to the version of the gene found within the mammalian genome, while v-Abl refers to the viral gene. Human abelson murine leukemia viral oncogene homolog 1 (abl-1) (genbank accession no. nm_007313), amino acids 248-531 with t334i mutation and n-terminal his-tag, mw = 33 kda, expressed in a baculovirus-infected sf9 cell expression system. Group: Enzymes. Synonyms: ABL1; JTK7; c-ABL; p150; Abl Kinase; ABL; bcr/abl; c-ABL1; v-abl. Abl Kinase. Mole weight: mol wt 33 kDa. Stability: -70°C. Form: aqueous solution. Source: Baculovirus infected Sf9 cells. Species: Human. ABL1; JTK7; c-ABL; p150; Abl Kinase; ABL; bcr/abl; c-ABL1; v-abl. Cat No: NATE-0013. |  |
| BMP Inhibitor III, LDN-212854 (Abl Inhibitor V, LDN212854, Bone Morphogenetic Protein Inhibitor III, PDGFR Tyrosine Kinase Inhibitor XXIV, RIP2 Inhibitor I, RIPK2 Inhibitor I, 5-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline) | A cell-permeable pyrazolopyrimidinyl quinoline that is superior to Dorsomorphin and DMH1 as an ATP-site-targeting, ALK1/2 inhibitor (IC50 = 2.40 and 1.30nM, respectively; [ATP] = 6uM) with respect to both potency and selectivity over ALK3/4/5 (IC50 = 0.858, 2.133, and 9.276uM, respectively). Also a potent RIPK2 inhibitor (IC50 = 6nM) with reduced potency against ABL1/c-abl, PDGFR-beta, ALK3, and PDGFR-alpha (IC50 = 40, 68, 85.8, and 650nM, respectively) and little inhibitory activity toward a panel of more than 190 kinases. Effectively inhibits ALK2- and ALK3-mediated C2C12 osteogenic differentiation (IC50 = 10 and 40.5nM, respectively) in vitro and prevents constitutively active ALK2 Q207D mutant-induced heterotopic ossification in mice (6mg/kg/12h via i.p.) in vivo. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. Molecular Formula: C??H??N?. US Biological Life Sciences. |  Worldwide |
| 1-Naphthyl PP1 | 1-Naphthyl PP1 (1-NA-PP 1) is a selective inhibitor of src family kinases and Protein Kinase D. 1-Naphthyl PP1 inhibits v-Src and c-Fyn, c-Abl, CDK2 and CAMK II with IC 50 s of 1.0, 0.6, 0.6, 18 and 22 μM, respectively [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 1-NA-PP 1. CAS No. 221243-82-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13941. |  |
| 1-Naphthyl PP1 | Selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl. (IC50 values are 1.0, 0.6, 0.6, 18 and 22 uM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively). Preferentially inhibits mutant over wild-type kinases (IC50 values are 1.5 vs 1000 nM for I338G v-src and v-src respectively). Group: Biochemicals. Grades: Highly Purified. CAS No. 221243-82-9. Pack Sizes: 10mg, 50mg. Molecular Formula: C19H19N5. US Biological Life Sciences. | Worldwide |
| 1-Naphthyl PP1 hydrochloride | 1-Naphthyl PP1 hydrochloride (1-NA-PP 1 hydrochloride) is a selective inhibitor of src family kinases. 1-Naphthyl PP1 hydrochloride inhibits v-Src and c-Fyn, c-Abl, CDK2 and CAMK II with IC 50 s of 1.0, 0.6, 0.6, 18 and 22 μM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 1-NA-PP 1 hydrochloride. CAS No. 956025-47-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13941B. | |
| 1-Naphthyl PP1 hydrochloride | 1-Naphthyl PP1 hydrochloride is a selective inhibitor of src family kinases, including v-Src and c-Fyn, tyrosine kinase c-Abl and CAMK II with IC50 values of 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively. It was considerably more potent and showed distinct substituent effects at the pyrazolopyrimidine core. It was cell-active, and potently blocked prostate cancer cell proliferation by inducing G2/M arrest. Uses: 1-naphthyl pp1 hydrochloride could potently block prostate cancer cell proliferation by inducing g2/m arrest. Synonyms: 1-Tert-butyl-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyriMidin-4-aMine hydrochloride; 1-NA-PP 1 hydrochloride. Grade: >98 %. CAS No. 956025-47-1. Molecular formula: C19H20ClN5. Mole weight: 353.85. |  |
| 2-Amino-5-bromobenzothiazole | 2-Amino-5-bromobenzothiazole is a chemical reagent used in the synthesis of pharmacologically active agents such as Abl kinase inhibitors for treatment of abnormal cell growth diseases or cytotoxic/anticancer agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 20358-03-6. Pack Sizes: 1g, 5g. Molecular Formula: C7H5BrN2S, Molecular Weight: 229.1. US Biological Life Sciences. | Worldwide |
| [(2S,6R)-6-{N4-Benzoylcydin-1-yl}-4-tritylmorpholin-2-yl]methyl dimethyl-phosphoramidochloridate | This product is a potent inhibitor of Abl kinases and was developed for the treatment of chronic myeloid leukemia (CML). It works by blocking the activity of the Bcr-Abl fusion protein, which drives the growth of CML cells. Clinical trials have shown promising results, with high rates of complete remission and durable responses in patients with CML who were resistant or intolerant to previous treatments. Synonyms: PMO-BzC; Morpholino C subunit; Phosphoramidochloridic acid, N,N-dimethyl-, [(2S,6R)-6-[4-(benzoylamino)-2-oxo-1(2H)-pyrimidinyl]-4-(triphenylmethyl)-2-morpholinyl]methyl ester; [(2S,6R)-6-[4-(Benzoylamino)-2-oxo-1(2H)-pyrimidinyl]-4-(triphenylmethyl)-2-morpholinyl]methyl N,N-dimethylphosphoramidochloridate; N4-Bz protected C PMO Monomer. Grade: 97%. CAS No. 956139-21-2. Molecular formula: C37H37ClN5O5P. Mole weight: 698.15. | |
| 4'-Hydroxy Dasatinib | 4'-Hydroxy Dasatinib is the formidable compound renowned for its unparalleled efficacy in studying chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL)operates through the discerning suppression of numerous malignant protein kinases. By specifically antagonizing BCR-ABL, this remarkable substance precipitates the induction of apoptosand the impediment of tumor proliferation. Synonyms: N-(2-Chloro-4-hydroxy-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4. Grade: > 95%. CAS No. 910297-57-3. Molecular formula: C22H26ClN7O3S. Mole weight: 504.01. | |
| Abl Cytosolic Substrate | Abl Cytosolic Substrate is a substrate for Abelson tyrosine kinase (Abl). Synonyms: L-Lysine, L-α-glutamyl-L-alanyl-L-isoleucyl-L-tyrosyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanyl-L-alanyl-L-lysyl-L-lysyl-; L-Lysine, N2-[N2-[N2-[N-[N-[1-[N-[N-[N-[N-(N-L-α-glutamyl-L-alanyl)-L-isoleucyl]-L-tyrosyl]-L-alanyl]-L-alanyl]-L-prolyl]-L-phenylalanyl]-L-alanyl]-L-lysyl]-L-lysyl]-; L-α-Glutamyl-L-alanyl-L-isoleucyl-L-tyrosyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanyl-L-alanyl-L-lysyl-L-lysyl-L-lysine; Glu-Ala-Ile-Tyr-Ala-Ala-Pro-Phe-Ala-Lys-Lys-Lys. Grade: ≥95%. CAS No. 168202-46-8. Molecular formula: C64H101N15O16. Mole weight: 1336.58. | |
| Abl Cytosolic Substrate acetate | Abl Cytosolic Substrate acetate is a substrate for Abelson tyrosine kinase (Abl). Synonyms: Glu-Ala-Ile-Tyr-Ala-Ala-Pro-Phe-Ala-Lys-Lys-Lys acetate salt; L-α-Glutamyl-L-alanyl-L-isoleucyl-L-tyrosyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanyl-L-alanyl-L-lysyl-L-lysyl-L-Lysine acetate salt. Grade: ≥95%. CAS No. 2918768-10-0. Molecular formula: C64H101N15O16.C2H4O2. Mole weight: 1396.63. | |
| Ack1 Inhibitor, AIM-100 (Activated Cdc42 Kinase 1 Inhibitor, (S)-5,6-Diphenyl-N-((tetrahydrofuran-2-yl)methyl)furo[2,3-d]pyrimidin-4-amine) | A cell-permeable furopyrimidine that acts as a potent, ATP-binding site-targeting, Ack1-selective inhibitor (IC50 = 22nM) and effectively prevents receptor-mediated Ack1 activation (by >90% in MEF & LAPC4 cultures; 16h 800nM), while exhibiting much reduced potency against Lyn, Lck, Abl1 and BTK (IC50 ≥346.7nM) and no inhibitory activity toward 25 other kinases. Shown to completely inhibit EGF-induced, but not androgen DHT- (dihydrotestosterone) stimulated, AR transcription activity in serum- and androgen-deprived prostate cancer LAPC4 cutlures. Effectively inhibits androgen-independent LNCaP prostate cancer growth both in vitro (by 60%; 72h 8uM) and in castrated mice in vivo (4mg/kg/96h injections on day 7/11/15/19/23/27 post tumor transplant). Group: Biochemicals. Grades: Highly Purified. CAS No. 873305-35-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| AIM-100 | AIM-100 is a potent and selective Ack1 tyrosine kinase with IC50 value of 24 nM. AIM-100, not only inhibited Ack1 activation but also able to suppress pTyr267-AR phosphorylation, binding of AR to PSA, NKX3.1, and TMPRSS2 promoters, and inhibit AR transcription activity. Ack1 tyrosine kinase activation correlates with pancreatic cancer progression. Ack1 inhibitors hold promise for therapeutic intervention to inhibit pancreatic tumor growth. Uses: Designed for use in research and industrial production. Additional or Alternative Names: AIM-100; AIM 100; AIM100. Product Category: Others. Appearance: Solid powder. CAS No. 873305-35-2. Molecular formula: C23H21N3O2. Mole weight: 371.44. Purity: >98%. IUPACName: N-[[(2S)-oxolan-2-yl]methyl]-5,6-diphenylfuro[2,3-d]pyrimidin-4-amine. Canonical SMILES: C12=NC=NC(NC[C@H]3OCCC3)=C1C(C4=CC=CC=C4)=C(C5=CC=CC=C5)O2. Product ID: ACM873305352. Alfa Chemistry ISO 9001:2015 Certified. |  |
| AP23464 | AP23464 is a potent adenosine 5'-triphosphate (ATP)-based inhibitor of Src and Abl kinases. It displays antiproliferative activity against a human CML cell line and Bcr-Abl-transduced Ba/F3 cells with an IC50=14 nM. Synonyms: AP-23464; AP 23464; (4-((2-cyclopentyl-9-(3-hydroxyphenethyl)-9H-purin-6-yl)amino)phenyl)dimethylphosphine oxide. Grade: >98%. CAS No. 845895-51-4. Molecular formula: C30H38N5O2P. Mole weight: 475.53. | |
| Asciminib | Asciminib, also known as ABL-001, is a potent and selective allosteric Bcr-Abl inhibitor. Asciminib inhibits Ba/F3 cell growth with an IC50 of 0.25 nM. Uses: Tyrosine kinase inhibitors. Synonyms: ABL-001; ABL 001; ABL001; N-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3R)-3-hydroxypyrrolidin-1-yl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide. CAS No. 1492952-76-7. Molecular formula: C20H18ClF2N5O3. Mole weight: 449.843. | |
| At9283 | AT9283 is a multi-targeted kinase inhibitor with potent activity against Aurora A/B, JAK2/3, Abl (T315I) and Flt3 (IC50s ranging from 1 to 30 nM). AT9283 inhibits growth and survival of multiple solid tumors in vitro and in vivo. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea;1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)ureaAT9283;AT9283, >=98%;N-cyclopropyl-N-[3-[5-(4-morpholinylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl]Urea;Urea, N-cyclopropyl-N-[3-[6-(4-morpholinylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl]-. Product Category: Inhibitors. CAS No. 896466-04-9. Molecular formula: C19H23N7O2. Mole weight: 381.438. Purity: 0.997. Density: 1.45. Product ID: ACM896466049. Alfa Chemistry ISO 9001:2015 Certified. | |
| AT9283 | AT-9283 is a broad spectrum kinase inhibitor that potently inhibits Aurora A, Aurora B, JAK2, JAK3, and c-ABL (IC50= 3, 3, 1.2, 1.1, and 4 nM, respectively). It also potently (IC50 = <1 μM) inhibits serine/threonine kinases as well as receptor and non-receptor tyrosine kinases. Synonyms: AT9283; AT 9283; AT-9283. Grade:>98%. CAS No. 896466-04-9. Molecular formula: C19H23N7O2. Mole weight: 381.43. | |
| AT9283 | AT9283 is a multi-targeted kinase inhibitor with potent activity against Aurora A/B , JAK2/3 , Abl (T315I) and Flt3 ( IC 50 s ranging from 1 to 30 nM). AT9283 inhibits growth and survival of multiple solid tumors in vitro and in vivo [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 896466-04-9. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-50514. | |
| AT-9283 L-lactate | AT9283 is a multikinase inhibitor, is also a small-molecule inhibitor of several kinases with potential antineoplastic activity. AT9283 binds to and inhibits Aurora kinases A and B, JAK2 (Janus kinase 2) and the kinase BCR-ABL, which may result in the inhibition of cellular division and proliferation and the induction of apoptosis in tumor cells that overexpress these kinases. Synonyms: AT 9283; AT9283. CAS No. 896466-76-5. Molecular formula: C19H23N7O2. Mole weight: 471.52. | |
| AZD0424 | AZD0424 is an orally bioavailable small molecule tyrosine kinase inhibitor. It targets both Abl and Src kinases with potential antineoplastic activity. It selectively inhibits both Src and Abl kinase activity and may result in the inhibition of tumor growth in susceptible tumor cells. Uses: Azd0424 has the inhibition of tumor growth in tumor cells. Synonyms: AZD 0424; AZD-0424; 1-(4-(2-((4-((6-chloro-[1,3]dioxolo[4,5-b]pyridin-7-yl)amino)-5-isopropoxyquinazolin-7-yl)oxy)ethyl)piperazin-1-yl)ethan-1-one; 7-(2-(4-Acetylpiperazin-1-yl)ethoxy)-4-(5-chloro-2,3-methylenedioxypyridin-4-ylamino)-5-isopropoxyquinazoline. Grade: 98%. CAS No. 692054-06-1. Molecular formula: C25H29ClN6O5. Mole weight: 528.99. | |
| Bafetinib | A substituted benzamide derivative structurally related to STI-571 (Imatinib Mesylate). It was identified as highly potent Bcr-Abl kinase inhibitor. Group: Biochemicals. Alternative Names: N-[3- ([4, 5'-Bipyrimidin]-2-ylamino) -4-methylphenyl]-4-[[ (3S) -3- (dimethylamino) -1-pyrrolidinyl]methyl]-3- (trifluoromethyl) benzamide; INNO 406; NS 187. Grades: Highly Purified. CAS No. 859212-16-1. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| BCR-ABL1-IN-1 | BCR-ABL1-IN-1 is a potent, orally active, and specific inhibitor of ABL kinase. BCR-ABL1-IN-1 has potential for elucidating the role of ABL kinases in the brain in non-clinical studies [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1488090-21-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145887. | |
| BCR-ABL-IN-1 | BCR-ABL-IN-1, a BCR-ABL tyrosine kinase inhibitor with a pIC50 of 6.46, may be used in the study of chronic myelogenous leukemia. Synonyms: N-[4-[1-(3-Aminopropyl)-1H-indole-4-yl]pyrimidine-2-yl]-3-(1,1,2,2-tetrafluoroethoxy)aniline; 1H-Indole-1-propanamine, 4-[2-[[3-(1,1,2,2-tetrafluoroethoxy)phenyl]amino]-4-pyrimidinyl]-; 4-[1-(3-Aminopropyl)-1H-indol-4-yl]-N-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-pyrimidinamine. Grade: ≥98%. CAS No. 188260-50-6. Molecular formula: C23H21F4N5O. Mole weight: 459.44. | |
| BCR-ABL-IN-2 | BCR-ABL-IN-2 is a BCR-ABL1 tyrosine kinase inhibitor, with IC50s of 57 and 773 nM for ABL1 native and ABL1T315I, respectively. Synonyms: (S)-6-(3-(tert-butyl)-5-(3-(2,3-dichlorophenyl)ureido)-1H-pyrazol-1-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; 3-Isoquinolinecarboxylic acid, 6-[5-[[[(2,3-dichlorophenyl)amino]carbonyl]amino]-3-(1,1-dimethylethyl)-1H-pyrazol-1-yl]-1,2,3,4-tetrahydro-, (3S)-. Grade: ≥95%. CAS No. 897369-18-5. Molecular formula: C24H25Cl2N5O3. Mole weight: 502.39. | |
| Bosutinib Isomer Methanoate | Bosutinib Isomer is the 3,5-dichloro-4-methoxy isomer of Bosutinib. It has been reported that this compound has been offered incorrectly as Bosutinib (B676095) C&E News 90 (21) 2012 34-35 and Levinson NM, Boxer SG (2012) Structural and Spectroscopic Analysis of the Kinase Inhibitor Bosutinib and an Isomer of Bosutinib Binding to the Abl Tyrosine Kinase Domain. PLoS ONE 7(4): e29828. doi:10. 1371/journal. pone. 0029828. Group: Biochemicals. Alternative Names: 4-[(3,5-Dichloro-4-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile Methanoate. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Bosutinib monohydrate | Bosutinib hydrate is a Src/Abl inhibitor used in the treatment of chronic myeloid leukemia (CML), a type of cancer that affects the blood and bone marrow. Bosutinib is a tyrosine kinase inhibitor that works by blocking the activity of BCR-ABL, a protein that promotes the growth of abnormal leukemia cells in patients with CML. BCR-ABL is formed as a result of a genetic abnormality known as the Philadelphia chromosome. It is indicated for the treatment of adults with newly diagnosed chronic phase CML as well as CML that is resistant or intolerant to prior therapy, including imatinib. Synonyms: Bosutinib hydrate; 3-Quinolinecarbonitrile, 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-, hydrate (1:1); 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile hydrate; Bosulif hydrate; KIN 001-160 hydrate; SK 606 hydrate; SKI 606 hydrate. Grade: 98%. CAS No. 918639-08-4. Molecular formula: C26H29Cl2N5O3.H2O. Mole weight: 548.46. | |
| Bosutinib N-oxide | Bosutinib N-oxide is an impurity of Bosutinib, a BCR-ABL and src tyrosine kinase inhibitor used as an antineoplastic agent. Synonyms: 3-Quinolinecarbonitrile, 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-4-oxido-1-piperazinyl)propoxy]-. Grade: 95%. CAS No. 2468737-96-2. Molecular formula: C26H29Cl2N5O4. Mole weight: 546.4. | |
| Casein Kinase II from Human, Recombinant | The Casein kinase 2 (EC 2.7.11.1) is a serine/threonine-selective protein kinase that is a tetramer of two alpha subunits and two beta subunits. The alpha subunits have the catalytic kinase domain. Casein kinase 2 has been implicated in cell cycle control, DNA repair, regulation of the circadian rhythm and other cellular processes. Casein kinase ii (ck2) is a constitutively active serine/threonine protein kinase composed of two 44 kda catalytic α-subunits and two 26 kda regulatory β-subunits in an α2β2 configuration to form stable heterotetramers. ck2 holoenzyme undergoes autophosphorylation at two serine residues (s2/s3) of its β-subunit. recen... ck2 is able to phosphorylate, under special circumstances, tyrosyl residues in proteins. ck2 is implicated in a variety of cellular functions. Group: Enzymes. Synonyms: EC 2.7.11.1; Casein Kinase II; CK2; CK II; Casein Kinase 2. CAS No. 9026-43-1. CK. Mole weight: a-subunit (45 kDa), b-subunit (25 kDa). The apparent molecular weight of the a-subunit estimated by SDS-PAGE is about 42 kDa. Activity: 859,000 units/mg. Storage: at -80°C. Avoid repeated freeze/thaw cycles. Form: 350 mM NaCl, 20 mM Tris-HCl (pH 7.5 25°C), 1 mM Na2EDTA, 2 mM DTT and 0.1% Triton X-100. Source: E. coli. Species: Human. EC 2.7.11.1; Casein Kinase II; CK2; CK II; Casein Kinase 2. Cat No: NATE-1271. | |
| Cenisertib | Cenisertib (AS-703569) is an ATP-competitive multi-kinase inhibitor that blocks the activity of Aurora-kinase-A/B, ABL1, AKT, STAT5 and FLT3. Cenisertib induces major growth-inhibitory effects by blocking the activity of several different molecular targets in neoplastic mast cells (MC). Cenisertib inhibits tumor growth in xenograft models of pancreatic, breast, colon, ovarian, and lung tumors and leukemia[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AS-703569; R-763. CAS No. 871357-89-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13072. | |
| CGP 76030 | CGP76030 is a ual-specific Src and Abl kinase inhibitor, inhibit growth and survival of cells expressing imatinib mesylate-resistant Bcr-Abl kinases. Uses: Ual-specific src and abl kinase inhibitor. Synonyms: CGP-76030; CGP76030; CGP76030; CGP-076030. 7-(4-(2-((2-methoxyethyl)amino)ethoxy)phenyl)-5-(3-methoxyphenyl)-7H-Pyrrolo(2,3-d)pyrimidin-4-amine. Grade: ≥98%. CAS No. 497152-38-2. Molecular formula: C24H27N5O3. Mole weight: 433.5. | |
| CGP77675 | CGP77675 is an orally active and potent inhibitor of Src family kinases. CGP77675 inhibits phosphorylation of peptide substrates and autophosphorylation of purified Src ( IC 50 s of 5-20 and 40 nM, respectively), and also inhibits Src, EGFR, KDR, v-Abl, and Lck with IC 50 s of 5-20, 40, 20, 150, 1000, 310, and 290 nM, respectively. Anticancer activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 234772-64-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W062835. | |
| CHMFL-ABL-039 | CHMFL-ABL-039 is a type II native inhibitor of ABL kinase and drug-resistant V299L mutant BCR-ABL with the IC50s of 7.9 and 27.9 nM, respectively. It is used in the study of chronic myeloid leukemia. Synonyms: N-{4-[2-({6-[(Cyclopropylcarbonyl)amino]-3-pyridinyl}amino)-2-oxoethyl]phenyl}-4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)benzamide; Benzeneacetamide, N-[6-[(cyclopropylcarbonyl)amino]-3-pyridinyl]-4-[[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)benzoyl]amino]-. CAS No. 2304344-56-5. Molecular formula: C31H33F3N6O3. Mole weight: 594.63. | |
| CHMFL-ABL-053 | CHMFL-ABL-053 is a potent and orally available inhibitor of BCR-ABL (IC50 = 70 nM) without inhibitory activity against c-KIT kinase that is a common target of BCR-ABL inhibitors currently used. A pharmacokinetic study revealed that it had 4.3h of half-life and 24% bioavailability in rats. It is developed for the treatment of chronic myeloid leukemia (CML). Uses: The treatment of chronic myeloid leukemia (cml). Synonyms: CHMFL-ABL-053; CHMFL-ABL053; CHMFL-ABL 053. 2 - ((3-Amino-4-methylphenyl)amino) - N - (2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)-4-(methylamino)pyrimidine-5-carboxamide. CAS No. 1808287-83-3. Molecular formula: C28H26F3N7O2. Mole weight: 549.56. | |
| CHMFL-ABL-121 | CHMFL-ABL-121 is a highly potent inhibitor of type II ABL kinase with IC50s of 2 nM and 0.2 nM against purified inactive ABL wt and T315I kinase protein, respectively. Synonyms: Propanamide, N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]-; N-{4-[(4-Methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl}-3-({3-[(E)-2-(2-pyridinyl)vinyl]-1H-indazol-6-yl}sulfanyl)propanamide. Grade: ≥97%. CAS No. 2270879-07-5. Molecular formula: C30H31F3N6OS. Mole weight: 580.67. | |
| CRT0066101 hydrochloride | CRT0066101 is an inhibitor of all three PKD isoforms (IC50s = 1, 2.5, and 2 nM for PKD1, PKD2, and PKD3, respectively). It exhibits selectivity for PKD against a panel of >90 protein kinases, including PKCα, PKBα, MEK, ERK, c-Raf, c-Src, and c-Abl. Synonyms: Phenol, 2-[4-[[(2R)-2-aminobutyl]amino]-2-pyrimidinyl]-4-(1-methyl-1H-pyrazol-4-yl)-, hydrochloride (1:3); (R)-2-(4-((2-Aminobutyl)amino)pyrimidin-2-yl)-4-(1-methyl-1H-pyrazol-4-yl)phenol trihydrochloride; 2-(4-{[(2R)-2-Aminobutyl]amino}pyrimidin-2-yl)-4-(1-methyl-1H-pyrazol-4-yl)phenol trihydrochloride. Grade: ≥95%. CAS No. 1781742-22-0. Molecular formula: C18H22N6O.3HCl. Mole weight: 447.79. | |
| CT-721 | CT-721 is a potent and time-dependent inhibitor of Bcr-Abl kinase with an IC50 of 21.3 nM for wild-type Bcr-Abl kinase, and has anti-chronic myeloid leukemia (CML) activity. Synonyms: (1S)-N-{3-[(6-Chloroimidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methylphenyl}-1-(4-methyl-1-piperazinyl)-5-indanecarboxamide; 1H-Indene-5-carboxamide, N-[3-[2-(6-chloroimidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methylphenyl]-2,3-dihydro-1-(4-methyl-1-piperazinyl)-, (1S)-. Grade: ≥98%. CAS No. 1388710-60-8. Molecular formula: C30H29ClN6O. Mole weight: 525.04. | |
| CZC-8004 | CZC-8004 is an aminopyrimidine which is a pan-kinase inhibitor that binds a range of tyrosine kinases, including ABL, BTK, FAK, FER, JAK1, SRC, SYK, TEC, TNK1, TYK2, and YES. Synonyms: Dianilinopyrimidine-01; CZC-00008004. Grade: ≥98%. CAS No. 916603-07-1. Molecular formula: C17H16FN5. Mole weight: 309.3. | |
| Dasatinib | Dasatinib, also known as BMS-354825, is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib binds to and inhibits the growth-promoting activities of these kinases. Apparently because of its less stringent binding affinity for the BCR-ABL kinase, dasatinib has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations. SRC-family protein-tyrosine kinases interact with variety of cell-surface receptors and participate in intracellular signal transduction pathways; tumorigenic forms can occur through altered regulation or expression of the endogenous protein and by way of virally-encoded kinase genes. Synonyms: BMS-354825; BMS354825; BMS354825. Grade: >98%. CAS No. 302962-49-8. Molecular formula: C22H26ClN7O2S. Mole weight: 488.01. | |
| Dasatinib-d8 | Dasatinib-d 8 is a deuterium labeled Dasatinib. Dasatinib is a dual Bcr-Abl and Src family tyrosine kinase inhibitor. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: BMS-354825-d8. CAS No. 1132093-70-9. Pack Sizes: 500 μg; 1 mg. Product ID: HY-10181S. | |
| Dasatinib-[d8] | Dasatinib-[d8] is an isotope labelled Dasatinib. Dasatinib is a Bcr-Abl and Src family tyrosine kinase inhibitor approved for the treatment of chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia. Synonyms: Dasatinib D8. Grade: 98% by HPLC; 98% atom D. CAS No. 1132093-70-9. Molecular formula: C22H18D8ClN7O2S. Mole weight: 496.05. | |
| Dasatinib metabolite M6 | Dasatinib metabolite M6 (Dasatinib carboxylic acid) is an oxidative metabolite of Dasatinib (HY-10181). Dasatinib is a potent and orally active dual Bcr-Abl and Src family tyrosine kinase inhibitor[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Dasatinib carboxylic acid. CAS No. 910297-53-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131669. | |
| Dasatinib Monohydrate | Dasatinib Monohydrate is a novel, potent and multi-targeted inhibitor that targets Abl, PDGFR, ephrin receptors, Src, c-Kit, and other Src-family kinases (LCK, HCK, FYN, and others). Uses: Antineoplastic agents. Synonyms: BMS-354825 Monohydrate; BMS 354825 Monohydrate; BMS354825 Monohydrate; N-(2-chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide hydrate. Grade: >98%. CAS No. 863127-77-9. Molecular formula: C22H28ClN7O3S. Mole weight: 506.02. | |
| DPH | DPH is a potent cell permeable c-Abl activator. It binds and alters the conformation of the myristoyl binding site of c-Abl tyrosine kinase. DPH exhibits potent enzymatic and cellular activity that stimulates the activation of c-Abl and may be used in c-Abl tyrosine kinase-mediated cell signaling studies. Synonyms: 5-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)imidazolidine-2,4-dione; 5-[3-(4-fluorophenyl)-1-phenylpyrazol-4-yl]imidazolidine-2,4-dione; MLS000036279; SMR000041163; 5-[3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]imidazolidine-2,4-dione; Oprea1_189167; cid_660311; CHEMBL1311135; SCHEMBL13740728; BDBM66241; DTXSID30349772; HMS2301N21; DPH, >=98% (HPLC); AKOS002169217; AKOS016293917; CS-0251; NCGC00020328-05; HY-12070; F83225; A913925; 5-[3-(4-fluorophenyl)-1-phenyl-pyrazol-4-yl]hydantoin; 5-[3-(4-fluorophenyl)-1-phenyl-1h-pyrazol-4-yl]-2,4-imidazolidinedione; 5-[3-(4-fluorophenyl)-1-phenyl-4-pyrazolyl]imidazolidine-2,4-dione; 5-[3-(4-fluorophenyl)-1-phenyl-pyrazol-4-yl]imidazolidine-2,4-dione. Grade: >98%. CAS No. 484049-04-9. Molecular formula: C18H13FN4O2. Mole weight: 336.32. | |
| eCF506 | eCF506 is a potent and highl selective inhibitor towards Src tyrosine kinase with a 1000-fold selectivity over ABL. eCF506 inhibits SRC at subnanomolar concentration (IC50 < 0.5 nM). It is said that eCF506 is the first drug candidate of a second generation of Src inhibitors that will not only help to understand the complexity of some cancers but also the development of safer combination therapies. Synonyms: eCF506; eCF-506; eCF 506.; tert-butyl N-[4-[4-amino-1-[2-[4-(dimethylamino)piperidin-1-yl]ethyl]pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl]carbamate; eCF506; Derivative 11a; GTPL9186; derivative 11a [PMID: 27115835]; tert-butyl N-[4-(4-amino-1-{2-[4-(dimethylamino)piperidin-1-yl]ethyl}-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxyphenyl]carbamate. Grade:>98%. CAS No. 1914078-41-3. Molecular formula: C26H38N8O3. Mole weight: 510.643. | |
| Flumatinib | Flumatinib is a multi-kinase inhibitor of c-Abl, PDGFRβ and c-Kit with IC50 values of 1.2 nM, 307.6 nM and 2662 nM respectively. It can predominantly inhibit the autophosphorylation of Bcr-Abl in K562 cell in vitro. It can inhibit the phosphorylation of c-Kit in Mo7e cell and the phosphorylation of PDGFR in Swiss3T3 cell in higher concentration. It has no or little effect on other tyrosine kinase including EGFR, KDR, c-Src andHER2. It can reduce the expression of C-MYC, HIF-1 α and VEGF in U266 cell line in a time- and dose-dependent manners. It effectively overcame the drug resistance of certain KIT mutants with activation loop mutations. It was developed by Jiangsu Hansoh Pharmaceutical Co., Ltd. and is currently in Phase III clinical trials in China for the treatment of chronic myelogenous leukemia (CML). Uses: Flumatinib is used for the treatment of chronic myelogenous leukemia (cml). Synonyms: 4-[(4-methylpiperazin-1-yl)methyl]-N-(6-methyl-5-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}pyridin-3-yl)-3-(trifluoromethyl)benzamide; HH-GV678; HHGV678; HH GV678; 4-[(4-Methyl-1-piperazinyl)methyl]-N-(6-methyl-5-{[4-(3-pyridinyl)-2-pyrimidinyl]amino}-3-pyridinyl)-3-(trifluoromethyl)benzamide. Grade: >98%. CAS No. 895519-90-1. Molecular formula: C29H29F3N8O. Mole weight: 562.59. | |
| Flumatinib Mesylate | Flumatinib mesylate, a derivative of imatinib, is a multi-kinase inhibitor for c-Abl, PDGFRβ and c-Kit. It is currently in Phase I and II clinical trials in China for the treatment of chronic myelogenous leukemia (CML). It effectively overcomes drug resistance of certain KIT mutants. It can reduce the expression of C-MYC, HIF-1 α and VEGF in U266 cell line in a time- and dose-dependent manners. Synonyms: HH-GV-678 mesylate. Grade: >98%. CAS No. 895519-91-2. Molecular formula: C30H33F3N8O4S. Mole weight: 658.69. | |
| FTI-277 | FTI-277, a peptide mimetic of the COOH-terminal Cys-Val-Ile-Met of K-Ras4B that inhibited potently FTase in vitro (IC50 = 500 pM) and was highly selective for FTase over geranylgeranyltransferase I (GGTase I) (IC50 = 50 nM). FTI-277, the methyl ester derivative of FTI-276, was extremely potent (IC50 = 100 nM) at inhibiting H-Ras, but not the geranylgeranylated Rap1A processing in whole cells. Treatment of H-Ras oncogene-transformed NIH 3T3 cells with FTI-277 blocked recruitment to the plasma membrane and subsequent activation of the serine/threonine kinase c-Raf-1 in cells transformed by farnesylated Ras (H-RasF), but not geranylgeranylated, Ras (H-RasGG). FTI-277 induced accumulation of cytoplasmic non-farnesylated H-Ras that was able to bind Raf and form cytoplasmic Ras/Raf complexes in which Raf kinase was not activated. Furthermore, FTI-277 blocked constitutive activation of mitogen-activated protein kinase (MAPK) in H-RasF, but not H-RasGG, or Raf-transformed cells. FTI-277 also inhibited oncogenic K-Ras4B processing and constitutive activation of MAPK, but the concentrations required were 100-fold higher than those needed for H-Ras inhibition. The results demonstrate that FTI-277 blocks Ras oncogenic signaling by accumulating inactive Ras/Raf complexes in the cytoplasm, hence preventing constitutive activation of the MAPK cascade. Uses: Radiation-sensitizing agents. Synonyms: FTI-277; FTI 277; FTI277. CAS No. 170006-73-2. M | |
| Ganetespib | Ganetespib, also known as STA-9090, is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Hsp90 inhibitor STA-9090 binds to and inhibits Hsp90, resulting in the proteasomal degradation of oncogenic client proteins, the inhibition of cell proliferation and the elevation of heat shock protein 72 (Hsp72); it may inhibit the activity of multiple kinases, such as c-Kit, EGFR, and Bcr-Abl, which as client proteins depend on functional Hsp90 for maintenance. Hsp90, a 90 kDa molecular chaperone upregulated in a variety of tumor cells, plays a key role in the conformational maturation, stability and function of "client" proteins within the cell, many of which are involved in signal transduction, cell cycle regulation and apoptosis, including kinases, transcription factors and hormone receptors. Hsp72 exhibits anti-apoptotic functions; its up-regulation may be used as a surrogate marker for Hsp90 inhibition. Synonyms: STA-9090; STA 9090; STA9090. Grade: >98%. CAS No. 888216-25-9. Molecular formula: C20H20N4O3. Mole weight: 364.40. | |
| GNF-2 | GNF-2 is a Bcr-Abl inhibitor that binds to the myristoyl binding pocket, an allosteric site distant from the active site, stabilizing the inactive form of the kinase. Thus, it can selectively inhibit Bcr-Abl phosphorylation (IC50 = 267 nM) without affecting native c-Abl or a panel of 63 additional kinases. Synonyms: GNF2; GNF-2; GNF 2. Grade: 98.73%. CAS No. 778270-11-4. Molecular formula: C18H13F3N4O2. Mole weight: 374.32. | |
| GNF-7 | GNF-7 is a type-II T315I inhibitor. GNF-7 inhibits Ack1 and germinal center kinase (GCK). GNF-7 is among the first type-II inhibitors capable of inhibiting T315I to be described and will serve as a valuable lead to design the third generation Bcr-Abl kinase inhibitors. Uses: Protein kinase inhibitors. Synonyms: GNF7; GNF 7; N-(4-methyl-3-(1-methyl-7-((6-methylpyridin-3-yl)amino)-2-oxo-1,4-dihydropyrimido[4,5-d]pyrimidin-3(2H)-yl)phenyl)-3-(trifluoromethyl)benzamide. Grade: 98%. CAS No. 839706-07-9. Molecular formula: C28H24F3N7O2. Mole weight: 547.54. | |
| Hck from Human, Recombinant | Hck is a member of the Src family of non-receptor associated protein tyrosine kinases (PTK). Hck has been shown to associate with and be activated by Bcr-Abl, which is a protein-tyrosine kinase that is expressed in chronic myelogenous leukemia. Group: Enzymes. Synonyms: Hck; HCK; tyrosine-protein kinase HCK; JTK9; p59Hck; p61Hck. Hck. Mole weight: mol wt 58 kDa. Storage: -70°C. Form: buffered aqueous glycerol solution; Solution in 50 mM Tris pH 7.5, containing 0.05 mM EDTA, 1mM DTT, 100 mM NaCl, 0.05% NP-40, and 50% glycerol. Source: Baculovirus infected insect cells. Species: Human. Hck; HCK; tyrosine-protein kinase HCK; JTK9; p59Hck; p61Hck. Cat No: NATE-0334. | |
| Herbimycin A | Herbimycin A, an ansamycin antibiotic , acts as a Src family kinase inhibitor. Herbimycin A binds to the SH domain and inhibits the activity of p60 v-src and p210 BCR-ABL Herbimycin A inhibits Hsp90 and impairs recovery from heat shock. Herbimycin A exhibits antiangiogenic activity in endothelial cells in vitro. Uses: Scientific research. Group: Natural products. CAS No. 70563-58-5. Pack Sizes: 1 mg; 2.5 mg; 500 μg; 100 μg. Product ID: HY-108486. | |
| Herbimycin A (Antibiotic TAN 420F, (15R)-17-Demethoxy-15-methoxy-11-O-methyl-geldanamycin) | Benzoquinone ansamycin antibiotic. Herbicidal compound. Potent, selective, irreversible and cell permeable protein tyrosine kinase inhibitor. Inhibitor of v-Src, Yes, Fps, Ros, Bcr-Abl and ErbB oncogene products. Antitumor compound. Antiangiogenic. Inhibits NF-kappaB activation and phosphorylation of phospholipase C-gamma1. Inhibitor of heat shock protein 90 (Hsp90). Binds Hsp90 and destabilizes client proteins leading to their ubiquitination and proteasomal degradation. Increases the sensitivity of certain cancer cells to chemotherapeutic agents. Neuroprotective. Antiparasitic, antischistosomal agent. Antiviral. Increase microtubules sensitivity to cold in plants. Group: Biochemicals. Grades: Highly Purified. CAS No. 70563-58-5. Pack Sizes: 100ug, 1mg. Molecular Formula: C30H42N2O9. US Biological Life Sciences. | Worldwide |
| HS 38 | HS 38 is an ATP-competitive inhibitor of DAPK (IC50 = 200 nM) and ZIPK (Kd = 280 nM). It also inhibits PIM3 kinase (IC50 = 200 nM) with no significant effect on Src or Abl kinases. HS 38 regulates programmed cell death and phosphorylation of non-muscle and smooth muscle myosin. Synonyms: HS 38; HS38; HS-38; 2-[[1-(3-Chlorophenyl)-4,5-dihydro-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl]thio]propanamide. Grade: ≥98% by HPLC. CAS No. 1030203-81-6. Molecular formula: C14H12CIN5O2S. Mole weight: 349.8. | |
| Imatinib | Imatinib (STI571) is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL , v-Abl , PDGFR and c-kit kinase activity. Imatinib (STI571) works by binding close to the ATP binding site, locking it in a closed or self-inhibited conformation, therefore inhibiting the enzyme activity of the protein semicompetitively [1] [2] [3] [4]. Imatinib also is an inhibitor of SARS-CoV and MERS-CoV [5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: STI571; CGP-57148B. CAS No. 152459-95-5. Pack Sizes: 10 mM * 1 mL; 200 mg; 500 mg; 1 g; 5 g. Product ID: HY-15463. | |
| Imatinib-d8 Methanesulfonate (STI-571-d8, CGP-57148B-d8) | A deuterated tyrosine kinase inhibitor. Highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). Group: Biochemicals. Alternative Names: Imatinib-d8 Methanesulfonate, STI-571-d8, CGP-57148B-d8, Glivec-d8. Grades: Highly Purified. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| Imatinib free base | Imatinib is a tyrosine kinase inhibitor with antineoplastic activity. Imatinib binds to an intracellular pocket located within tyrosine kinases (TK), thereby inhibiting ATP binding and preventing phosphorylation and the subsequent activation of growth receptors and their downstream signal transduction pathways. This agent inhibits TK encoded by the bcr-abl oncogene as well as receptor TKs encoded by the c-kit and platelet-derived growth factor receptor (PDGFR) oncogenes. Imatinib was approved for medical use in the United States in 2001. Uses: Designed for use in research and industrial production. Additional or Alternative Names: CGP 57148; CGP57148; CGP-57148; CGP57148B; CGP-57148B; CGP 57148B; STI571; STI-571; STI 571. Product Category: Inhibitors. Appearance: White to off-white to brownish or yellowish tinged crystalline powder. CAS No. 152459-95-5. Molecular formula: C29H31N7O. Mole weight: 493.62. Purity: >98%. IUPACName: N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide. Canonical SMILES: O=C(NC1=CC=C(C)C(NC2=NC=CC(C3=CC=CN=C3)=N2)=C1)C4=CC=C(CN5CCN(C)CC5)C=C4. Product ID: ACM152459955. Alfa Chemistry ISO 9001:2015 Certified. | |
| Imatinib, Free base | An inhibitor of the bcr-abl tyrosine kinase. It acts by binding to the ATP binding site of bcr-abl. Imatinib also stimulates the entry of the bcr-abl tyrosine kinase into the nucleus, where it cannot perform its anti-apoptopic functions. It inhibits EOL-1 cell viability (IC50=0.5nm), phosphorylation of a fusion protein (IC50=30nm), and viability of BaF3 cells expressing Rhe-PDGFRa in the absence of IL-3 (IC50 =0.17nm). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 100ug, 1g. US Biological Life Sciences. | Worldwide |
| Imatinib Mesylate | Imatinib Mesylate (STI571 Mesylate) is a tyrosine kinases inhibitor that inhibits c-Kit , Bcr-Abl , and PDGFR ( IC 50 =100 nM) tyrosine kinases. Uses: Scientific research. Group: Signaling pathways. Alternative Names: STI571 Mesylate; CGP-57148B Mesylate. CAS No. 220127-57-1. Pack Sizes: 10 mM * 1 mL; 200 mg; 500 mg; 1 g; 5 g. Product ID: HY-50946. | |
| Imatinib, Methanesulfonate Salt (STI-571, CGP-57148B) | A tyrosine kinase inhibitor. Highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). Imatinib inhibits bcr-abl tyrosine kinase activity, upon which some types of tumor cells depend for growth. Imatinib acts by binding to the ATP binding site of bcr-abl and competitively inhibiting its tyrosine kinase activity. Imatinib is selective for bcr-abl, but it also targets several other kinases (c-kit and PDGF-R). (1). Group: Biochemicals. Alternative Names: 4- [ (4-Methyl-1-piperazinyl) methyl] -N- [4-methyl-3- [ [4- (3-pyridinyl) -2-pyrimidinyl] amino] phenyl] benzamide Methanesulfonate; CGP 57148B; Imatinib Mesilate; Imatinib Methanesulfonate; Imatinib Mesylate; STI 571; Bcr-abl Inhibitor IV; Abl Inhibitor V, PDGFR Tyrosine Kinase Inhibitor XXIV, c-Kit Inhibitor IV. Grades: Highly Purified. CAS No. 220127-57-1. Pack Sizes: 25mg, 1g, 5g, 10g. US Biological Life Sciences. | Worldwide |
| Kw-2449 | KW-2449 is a multi-targeted kinase inhibitor of FLT3, ABL, ABLT315I and Aurora kinase with IC50s of 6.6, 14, 4 and 48 nM, respectively. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. CAS No. 1000669-72-6. Molecular formula: C20H20N4O. Mole weight: 332.4. Purity: >99%. Product ID: ACM1000669726. Alfa Chemistry ISO 9001:2015 Certified. | |
| KW-2449 | KW-2449 is a multi-targeted kinase inhibitor of FLT3, ABL, ABLT315I and Aurora kinase with IC50s of 6.6, 14, 4 and 48 nM, respectively.. Uses: Scientific research. Group: Signaling pathways. CAS No. 1000669-72-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10339. | |
| λ Protein phosphatase | λ Protein phosphatase is a serine/threonine phosphatase encoded by bacteriophage Lambda. λ Protein phosphatase is activated with requirement for divalent cations, such as Mn 2+. λ Protein phosphatase is able to dephosphorylate casein, adenovirus E1A protein, and the α subunit of phosphorylase kinase [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 401941-75-1. Pack Sizes: 10 KU. Product ID: HY-E70373. | |
| MAPK/MAK/MRK overlapping kinase (11-20) | MAPK/MAK/MRK overlapping kinase (11-20) is a 10-aa peptide. MAPK/MAK/MRK overlapping kinase is able to phosphorylate several exogenous substrates and to undergo autophosphorylation. | |
| MAPK/MAK/MRK overlapping kinase (32-40) | MAPK/MAK/MRK overlapping kinase (32-40) is a 9-aa peptide. MAPK/MAK/MRK overlapping kinase is able to phosphorylate several exogenous substrates and to undergo autophosphorylation. | |
| MAPK/MAK/MRK overlapping kinase (352-360) | MAPK/MAK/MRK overlapping kinase (352-360) is a 9-aa peptide. MAPK/MAK/MRK overlapping kinase is able to phosphorylate several exogenous substrates and to undergo autophosphorylation. | |
| Mirk/Dyrk1B Inhibitor, Compound A (N- (2-Chloro-5- (3-chlorobenzylcarbamoyl) phenyl) -2-methoxy-7-oxo-7, 8-dihydropyrido[2, 3-d]pyrimidine-6-carboxamide, N- (2-Chloro-5- ( (3-chlorobenzyl) carbamoyl) phenyl) -7-hydroxy-2-methoxypyrido[2, 3-d]pyrimidine-6-carboxamide) | A cell-permeable di hydropyridopyrimidine-carboxamide compound that acts as a potent and reversible inhibitor of Mirk/Dyrk1B and Dyrk1A kinases (IC50 = 68 and 22nM). Exhibits very high selectivity for Mirk/Dyrk1B compared to Abl, Flt3, and MARK1 (64, 56 and 73% inhibition at 10uM, respectively) and a panel of 46 other kinases. Shown to induce activation of caspase-3 and sensitize tumor cells to the action of gemcitabine and cisplatin, possibly by de-stabilizing p27. Preferentially increases cycling in Mirk-elevated quiescent pancreatic cancer cells (SU86.86, Panc1, AsPc1, and SW620 at ~1uM). Also, shown to increase level of superoxides in quiescent pancreatic tumor cells (Panc1, SU86.86, and AsPc1) by blocking SOD2 and SOD3 activities. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| N-Desmethyl Imatinib (CGP-74588) | A metabolite of Imatinib, a tyrosine kinase inhibitor which is highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). Group: Biochemicals. Alternative Names: N-Desmethyl Gleevec, CGP-74588. Grades: Highly Purified. CAS No. 404844-02-6. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| N-Desmethyl Imatinib-d8 | A deuterated metabolite of N-Desmethyl Imatinib, a tyrosine kinase inhibitor which is highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). Group: Biochemicals. Alternative Names: N-Desmethyl Gleevec-d8. Grades: Highly Purified. Pack Sizes: 250ug. US Biological Life Sciences. | Worldwide |
| N-Desmethyl Imatinib-[d8] | N-Desmethyl Imatinib-[d8] is a deuterated metabolite of gleevec, a tyrosine kinase inhibitor specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). Synonyms: N-Desmethyl Imatinib D8; N-Desmethyl Gleevec-d8. Grade: ≥96% by HPLC; ≥98% atom D. CAS No. 1185103-28-9. Molecular formula: C28H21D8N7O. Mole weight: 487.64. | |
Our database is helping our users find suppliers everyday.
