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Acetyl-L-lysine is an acetylated form of the amino acid L-lysine. Acetyl-L-lysine can participate in protein acylation processes, affecting protein functions such as stability and enzyme activity [1]. Uses: Scientific research. Group: Natural products. CAS No. 1946-82-3. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-W048838.
dihydrolipoyllysine-residue acetyltransferase
A multimer (24-mer or 60-mer, depending on the source) of this enzyme forms the core of the pyruvate dehydrogenase multienzyme complex, and binds tightly both EC 1.2.4.1, pyruvate dehydrogenase (acetyl-transferring) and EC 1.8.1.4, dihydrolipoyl dehydrogenase. The lipoyl group of this enzyme is reductively acetylated by EC 1.2.4.1, and the only observed direction catalysed by EC 2.3.1.12 is that where the acetyl group is passed to coenzyme A. Group: Enzymes. Synonyms: acetyl-CoA:dihydrolipoamide S-acetyltransferase; dihydrolipoamide S-acetyltransferase; d. Enzyme Commission Number: EC 2.3.1.12. CAS No. 9032-29-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2058; dihydrolipoyllysine-residue acetyltransferase; EC 2.3.1.12; 9032-29-5; acetyl-CoA:dihydrolipoamide S-acetyltransferase; dihydrolipoamide S-acetyltransferase; dihydrolipoate acetyltransferase; dihydrolipoic transacetylase; dihydrolipoyl acetyltransferase; lipoate acetyltransferase; lipoate transacetylase; lipoic acetyltransferase; lipoic acid acetyltransferase; lipoic transacetylase; lipoylacetyltransferase; thioltransacetylase A; transacetylase X; enzyme-dihydrolipoyllysine:acetyl-CoA S-acetyltransferase; acetyl-CoA:enzyme 6-N-(dihydrolipoyl)lysine S-acetyltransferase. Cat No: EXWM-2058.
DL-LysineAcetylsalicylate
Non-steroidal anti-inflammatory drugs (NSAIDs) may inhibit cancer growth. Group: Biochemicals. Alternative Names: 2-(Acetyloxy)benzoate. Grades: Highly Purified. CAS No. 62952-06-1. Pack Sizes: 100mg. US Biological Life Sciences.
Worldwide
Fmoc-N'-acetyl-L-lysine
Fmoc-N'-acetyl-L-lysine. Group: Biochemicals. Alternative Names: Fmoc-Lys(Ac)-OH. Grades: Highly Purified. CAS No. 159766-56-0. Pack Sizes: 1g, 2g, 5g, 10g, 25g. Molecular Formula: C23H26N2O5. US Biological Life Sciences.
Worldwide
LysineAcetylsalicylate Impurity 1
LysineAcetylsalicylate Impurity 1. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C13H18N2O4. Mole Weight: 266.3. Catalog: APB12392.
LysineAcetylsalicylate Impurity 2
LysineAcetylsalicylate Impurity 2. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C15H20N2O5. Mole Weight: 308.33. Catalog: APB12393.
LysineAcetylsalicylate Impurity 3
LysineAcetylsalicylate Impurity 3. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C13H18N2O4. Mole Weight: 266.3. Catalog: APB12394.
LysineAcetylsalicylate Impurity 4
LysineAcetylsalicylate Impurity 4. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C15H20N2O5. Mole Weight: 308.33. Catalog: APB12395.
Lysineacetylsalicylate with glycine
Lysineacetylsalicylate with glycine. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1kg, 2kg, 5kg, 10kg, 25kg. US Biological Life Sciences.
Worldwide
lysine N-acetyltransferase
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. This enzyme participates in lysine degradation. Group: Enzymes. Synonyms: lysineacetyltransferase; acetyl-phosphate:L-lysine 6-N-acetyltransferase. Enzyme Commission Number: EC 2.3.1.32. CAS No. 37257-12-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2210; lysine N-acetyltransferase; EC 2.3.1.32; 37257-12-8; lysineacetyltransferase; acetyl-phosphate:L-lysine 6-N-acetyltransferase. Cat No: EXWM-2210.
N2-citryl-N6-acetyl-N6-hydroxylysine synthase
Requires Mg2+. Aerobactin is one of a group of high-affinity iron chelators known as siderophores and is produced under conditions of iron deprivation. It is a dihydroxamate comprising two molecules of N6-acetyl-N6-hydroxy-L-lysine and one molecule of citrate. This enzyme catalyses the first of two synthase reactions to link N6-acetyl-N6-hydroxy-L-lysine and citrate. Group: Enzymes. Synonyms: Nα-citryl-Nε-acetyl-Nε-hydroxylysine synthase; iucA (gene name). Enzyme Commission Number: EC 6.3.2.38. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5755; N2-citryl-N6-acetyl-N6-hydroxylysine synthase; EC 6.3.2.38; Nα-citryl-Nε-acetyl-Nε-hydroxylysine synthase; iucA (gene name). Cat No: EXWM-5755.
N6-acetyl-β-lysine transaminase
A pyridoxal-phosphate protein. Group: Enzymes. Synonyms: ε-acetyl-β-lysine aminotransferase. Enzyme Commission Number: EC 2.6.1.65. CAS No. 71768-10-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2906; N6-acetyl-β-lysine transaminase; EC 2.6.1.65; 71768-10-0; ε-acetyl-β-lysine aminotransferase. Cat No: EXWM-2906.
Involved in the synthesis of aerobactin from lysine in a strain of Escherichia coli. Group: Enzymes. Synonyms: N6-hydroxylysine:acetyl CoA N6-transacetylase; N6-hydroxylysineacetylase; acetyl-CoA:6-N-hydroxy-L-lysine 6-acetyltransferase; N6-hydroxylysine O-acetyltransferase (incorrect). Enzyme Commission Number: EC 2.3.1.102. CAS No. 101077-53-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2041; N6-hydroxylysine N-acetyltransferase; EC 2.3.1.102; 101077-53-6; N6-hydroxylysine:acetyl CoA N6-transacetylase; N6-hydroxylysineacetylase; acetyl-CoA:6-N-hydroxy-L-lysine 6-acetyltransferase; N6-hydroxylysine O-acetyltransferase (incorrect). Cat No: EXWM-2041.
Na-Acetyl-L-lysine 99+% (HPLC)
Na-Acetyl-L-lysine 99+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g. US Biological Life Sciences.
A lysine analog used in the preparation of selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF. Group: Biochemicals. Alternative Names: Ac-L-Lys-NH2·HCl; Ac-Lys-NH? HCl; (2S)-2-(Acetylamino)-6-aminohexanamide Hydrochloride; (S)-2-(Acetylamino)-6-aminohexanamide Monohydrochloride; N-Acetyllysine Amide Hydrochloride. Grades: Highly Purified. CAS No. 104584-11-4. Pack Sizes: 100mg, 250mg, 1g. Molecular Formula: C8H17N3O2·HCl, Molecular Weight: 223.7. US Biological Life Sciences.
Worldwide
Na-Acetyl-L-lysine methyl amide 98+% (TLC)
Na-Acetyl-L-lysine methyl amide 98+% (TLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 100mg, 250mg, 1g, 5g. US Biological Life Sciences.
Na-Fmoc-Ne-7-methoxycoumarin-4-acetyl-L-lysine 99+% (TLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 100mg, 250mg. US Biological Life Sciences.
Worldwide
Na-Fmoc-Ne-acetyl-L-lysine 98+% (HPLC)
Na-Fmoc-Ne-acetyl-L-lysine 98+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g. US Biological Life Sciences.
Worldwide
Na-Fmoc-Ne-acetyl-lysine Merrifield resin
Na-Fmoc-Ne-acetyl-lysine Merrifield resin. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g. US Biological Life Sciences.
Worldwide
N-alpha-Acetyl-L-lysine
N-alpha-Acetyl-L-lysine. Group: Biochemicals. Alternative Names: Ac-L-Lys-OH. Grades: Highly Purified. CAS No. 1946-82-3. Pack Sizes: 2g, 5g, 10g, 25g. US Biological Life Sciences.
Worldwide
Nα-Acetyl-L-lysine
Nα-Acetyl-L-Lysine is an antibacterial lysine analogue that targets lysine riboswitches. Nα-Acetyl-L-Lysine is used in the metabolomic characterization of ovarian epithelial carcinomas which allows for better therapeutic management of patients. The presence of Nα-Acetyl-L-Lysine and other N-acetylated amino acids in the urine can be used to detect aminoacylase I deficiency. Synonyms: Ac-L-Lys-OH; N-Acetyl-L-lysine; AC-LYSINE; L-Lysine,N2-acetyl; Nalpha-Acetyl-L-lysine; N2-Acetyl-L-lysine. Grades: ≥ 99% (HPLC). CAS No. 1946-82-3. Molecular formula: C8H16N2O3. Mole weight: 188.20.
A lysine analog used in the preparation of selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF. Synonyms: Ac-L-Lys-NH2 HCl; N-Acetyl-L-Lysine Amide Hydrochloride; (2S)-2-acetamido-6-aminohexanamide hydrochloride. Grades: ≥ 99% (TLC). CAS No. 104584-11-4. Molecular formula: C8H17N3O2·HCl. Mole weight: 223.70.
N-alpha-Acetyl-L-lysine methyl amide
N-alpha-Acetyl-L-lysine methyl amide. Group: Biochemicals. Alternative Names: Ac-L-Lys-NHMe. Grades: Highly Purified. CAS No. 6367-10-8. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. US Biological Life Sciences.
N-alpha-Acetyl-Nε-Boc-L-lysine. Group: Biochemicals. Alternative Names: Ac-L-Lys(Boc)-OH. Grades: Highly Purified. CAS No. 23500-04-1. Pack Sizes: 500mg, 1g. US Biological Life Sciences.
Involved in the synthesis of cell-wall peptidoglycan. The D-lysine is attached to the peptide chain at the N6 position. The enzyme from Thermotoga maritima also performs the reaction of EC 6.3.2.7, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase. Group: Enzymes. Synonyms: UDP-MurNAc-L-Ala-D-Glu:D-Lys ligase; D-lysine-adding enzyme. Enzyme Commission Number: EC 6.3.2.37. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5754; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-D-lysine ligase; EC 6.3.2.37; UDP-MurNAc-L-Ala-D-Glu:D-Lys ligase; D-lysine-adding enzyme. Cat No: EXWM-5754.
Involved in the synthesis of a cell-wall peptide in bacteria. This enzyme adds lysine in some Gram-positive organisms; in others and in Gram-negative organisms EC 6.3.2.13 (UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-2,6-diaminopimelate ligase) adds 2,6-diaminopimelate instead. Group: Enzymes. Synonyms: MurE synthetase; UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine synthetase; uridine diphospho-N-acetylmuramoylalanyl-D-glutamyllysine synthetase; UPD-MurNAc-L-Ala-D-Glu:L-Lys ligase; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:L-lysine γ-ligase (ADP-forming). Enzyme Commission Number: EC 6.3.2.7. CAS No. 9023-51-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5770; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase; EC 6.3.2.7; 9023-51-2; MurE synthetase; UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine synthetase; uridine diphospho-N-acetylmuramoylalanyl-D-glutamyllysine synthetase; UPD-MurNAc-L-Ala-D-Glu:L-Lys ligase; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:L-lysine γ-ligase (ADP-forming). Cat No: EXWM-5770.
Also acts on L-seryl-tRNASer. Group: Enzymes. Synonyms: alanyl-transfer ribonucleate-uridine diphosphoacetylmuramoylpentapeptide transferase; UDP-N-acetylmuramoylpentapeptide lysine N6-alanyltransferase; uridine diphosphoacetylmuramoylpentapeptide lysine N6-alanyltransferase; L-alanyl-tRNA:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine 6-N-alanyltransferase; L-alanyl-tRNA:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine N6-alanyltransferase. Enzyme Commission Number: EC 2.3.2.10. CAS No. 37257-26-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2283; UDP-N-acetylmuramoylpentapeptide-lysine N6-alanyltransferase; EC 2.3.2.10; 37257-26-4; alanyl-transfer ribonucleate-uridine diphosphoacetylmuramoylpentapeptide transferase; UDP-N-acetylmuramoylpentapeptide lysine N6-alanyltransferase; uridine diphosphoacetylmuramoylpentapeptide lysine N6-alanyltransferase; L-alanyl-tRNA:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine 6-N-alanyltransferase; L-alanyl-tRNA:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine N6-alanyltransferase. Cat No: EXWM-2283.
Ac2-26 TFA
Ac2-26 TFA is an annexin/lipocortin 1-mimetic peptide that inhibits leukocyte extravasation. It promotes detachment of neutrophils from activated mesenteric endothelium and accelerates epithelial wound repair after induced colonic injury in mice in vivo. It reduces neutrophil adhesion and emigration. It has anti-inflammatory effect. Synonyms: Ala-Met-Val-Ser-Glu-Phe-Leu-Lys-Gln-Ala-Trp-Phe-Ile-Glu-Asn-Glu-Glu-Gln-Glu-Tyr-Val-Gln-Thr-Val-Lys.TFA; Annexin A1 (1-25) (dephosphorylated) (human).TFA; L-Lysine, N-acetyl-L-alanyl-L-methionyl-L-valyl-L-seryl-L-α-glutamyl-L-phenylalanyl-L-leucyl-L-lysyl-L-glutaminyl-L-alanyl-L-tryptophyl-L-phenylalanyl-L-isoleucyl-L-α-glutamyl-L-asparaginyl-L-α-glutamyl-L-α-glutamyl-L-glutaminyl-L-α-glutamyl-L-tyrosyl-L-valyl-L-glutaminyl-L-threonyl-L-valyl-, trifluoroacetic acid. Grades: ≥95%. Molecular formula: C143H211F3N32O46S. Mole weight: 3203.45.
Ac9-25
Ac9-25 is a N-terminal peptide of Annexin I (AI/Lipocortin I) that inhibits leukocyte extravasation. It stimulates neutrophil NADPH oxidase activation by acting as a formyl peptide receptor 1 (FPR1) ligand. Synonyms: L-Lysine, N2-acetyl-L-glutaminyl-L-alanyl-L-tryptophyl-L-phenylalanyl-L-isoleucyl-L-α-glutamyl-L-asparaginyl-L-α-glutamyl-L-α-glutamyl-L-glutaminyl-L-α-glutamyl-L-tyrosyl-L-valyl-L-glutaminyl-L-threonyl-L-valyl-; N2-Acetyl-L-glutaminyl-L-alanyl-L-tryptophyl-L-phenylalanyl-L-isoleucyl-L-α-glutamyl-L-asparaginyl-L-α-glutamyl-L-α-glutamyl-L-glutaminyl-L-α-glutamyl-L-tyrosyl-L-valyl-L-glutaminyl-L-threonyl-L-valyl-L-lysine; Ac-Gln-Ala-Trp-Phe-Ile-Glu-Asn-Glu-Glu-Gln-Glu-Tyr-Val-Gln-Thr-Val-Lys-OH. Grades: ≥95%. CAS No. 284040-76-2. Molecular formula: C99H143N23O33. Mole weight: 2183.35.
Ac9-25 acetate
Ac9-25 acetate is an N-terminal peptide of Annexin I (AI/Lipocortin I) that inhibits leukocyte extravasation. It stimulates neutrophil NADPH oxidase activation by acting as a formyl peptide receptor 1 (FPR1) ligand. Synonyms: L-Lysine, N2-acetyl-L-glutaminyl-L-alanyl-L-tryptophyl-L-phenylalanyl-L-isoleucyl-L-α-glutamyl-L-asparaginyl-L-α-glutamyl-L-α-glutamyl-L-glutaminyl-L-α-glutamyl-L-tyrosyl-L-valyl-L-glutaminyl-L-threonyl-L-valyl-, acetate; N2-Acetyl-L-glutaminyl-L-alanyl-L-tryptophyl-L-phenylalanyl-L-isoleucyl-L-α-glutamyl-L-asparaginyl-L-α-glutamyl-L-α-glutamyl-L-glutaminyl-L-α-glutamyl-L-tyrosyl-L-valyl-L-glutaminyl-L-threonyl-L-valyl-L-lysine acetate; Ac-Gln-Ala-Trp-Phe-Ile-Glu-Asn-Glu-Glu-Gln-Glu-Tyr-Val-Gln-Thr-Val-Lys-OH acetate. Grades: ≥95%. Molecular formula: C101H147N23O35. Mole weight: 2243.38.
acetyl-CoA C-acetyltransferase
This enzyme participates in 10 metabolic pathways: fatty acid metabolism, synthesis and degradation of ketone bodies, valine, leucine and isoleucine degradation, lysine degradation, tryptophan metabolism, pyruvate metabolism, benzoate degradation via coa ligation, propanoate metabolism, butanoate metabolism, and two-component system-general. Group: Enzymes. Synonyms: acetoacetyl-CoA thiolase; β-acetoacetyl coenzyme A thiolase; 2-methylacetoacetyl-CoA thiolase [misleading]; 3-oxothiolase; acetyl coenzyme A thiolase; acetyl-CoA acetyltransferase; acetyl-CoA:N-acetyltransferase; thiolase II. Enzyme Commission Number: EC 2.3.1.9. CAS No. 9027-46-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2271; acetyl-CoA C-acetyltransferase; EC 2.3.1.9; 9027-46-7; acetoacetyl-CoA thiolase; β-acetoacetyl coenzyme A thiolase; 2-methylacetoacetyl-CoA thiolase [misleading]; 3-oxothiolase; acetyl coenzyme A thiolase; acetyl-CoA acetyltransferase; acetyl-CoA:N-acetyltransferase; thiolase II. Cat No: EXWM-2271.
The major encephalitogenic epitope in myelin basic protein (MBP). Synonyms: Ac-Ala-Ser-Gln-Lys-Arg-Pro-Ser-Gln-Arg-Ser-Lys; MBP (1-11), mouse; AC-ASQKRPSQRSK-OH; Acetyl-myelin Basic Protein (Mouse,1-11); Myelin Basic Protein (2-12) Acetyl; N-acetyl-L-alanyl-L-seryl-L-glutaminyl-L-lysyl-L-arginyl-L-prolyl-L-seryl-L-glutaminyl-L-arginyl-L-seryl-L-lysine. Grades: ≥95%. CAS No. 125366-42-9. Molecular formula: C53H95N21O18. Mole weight: 1314.45.
aerobactin synthase
Requires Mg2+. Aerobactin is one of a group of high-affinity iron chelators known as siderophores and is produced under conditions of iron deprivation. It is a dihydroxamate comprising two molecules of N6-acetyl-N6-hydroxy-L-lysine and one molecule of citric acid. This enzyme catalyses the second of two synthase reactions to link N6-acetyl-N6-hydroxy-L-lysine and citrate. Group: Enzymes. Synonyms: iucC (gene name). Enzyme Commission Number: EC 6.3.2.39. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5756; aerobactin synthase; EC 6.3.2.39; iucC (gene name). Cat No: EXWM-5756.
α-Conotoxin MI
α-Conotoxin MI has been isolated from the venom of the sea snail Conus imperialis. The conotoxin is a ligand for nicotinic acetylcholine receptors. Synonyms: Alpha-Conotoxin MI; Conotoxin G I, 1-(N2-glycyl-L-arginine)-4-L-histidine-9-L-lysine-10-L-asparagine-. CAS No. 88217-10-1. Molecular formula: C58H88N22O17S4. Mole weight: 1493.72.
α-tubulin N-acetyltransferase
The enzyme from Chlamydomonas flagella also acetylates mammalian brain α-tubulin. Group: Enzymes. Synonyms: α-tubulin acetylase; TAT; α-tubulin acetyltransferase; tubulin N-acetyltransferase; acetyl-CoA:α-tubulin-L-lysine N-acetyltransferase; acetyl-CoA:[α-tubulin]-L-lysine 6-N-acetyltransferase. Enzyme Commission Number: EC 2.3.1.108. CAS No. 99889-90-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2046; α-tubulin N-acetyltransferase; EC 2.3.1.108; 99889-90-4; α-tubulin acetylase; TAT; α-tubulin acetyltransferase; tubulin N-acetyltransferase; acetyl-CoA:α-tubulin-L-lysine N-acetyltransferase; acetyl-CoA:[α-tubulin]-L-lysine 6-N-acetyltransferase. Cat No: EXWM-2046.
Beta-Ala-Lys-AMCA
Fluorescent dipeptide derivative, which could be used as an excellent reporter molecule for studying the oligopeptide transport system in brain cell cultures. Group: Biochemicals. Alternative Names: b-Ala-(L)-Lys-N-7-amino-4-methylcoumarin-3-acetic acid; b-Ala-Lys-Nε-AMCA; ß-Ala-Lys-Nε-AMCA; β-Alanyl-Nε-(7-Amino-4-Methyl-2-Oxo-2H-1-Benzopyran-3-Acetyl)-L-Lysine. Grades: Highly Purified. Pack Sizes: 1mg, 5mg. Molecular Formula: C21H28N4O6, Molecular Weight: 432.47. US Biological Life Sciences.
Worldwide
BIO-11006
BIO-11006 is a myristoylated alanine-rich C kinase substrate (MARCKS) inhibitor, similar to MANS peptides. Synonyms: BIO-11006 peptide; L-Lysine, N-acetylglycyl-L-alanyl-L-glutaminyl-L-phenylalanyl-L-seryl-L-lysyl-L-threonyl-L-alanyl-L-alanyl-; N-Acetylglycyl-L-alanyl-L-glutaminyl-L-phenylalanyl-L-seryl-L-lysyl-L-threonyl-L-alanyl-L-alanyl-L-lysine; BIO 11006; BIO11006; Ac-Gly-Ala-Gln-Phe-Ser-Lys-Thr-Ala-Ala-Lys-OH. Grades: ≥95%. CAS No. 901117-03-1. Molecular formula: C46H75N13O15. Mole weight: 1050.17.
The ETV1 transcription factor is phosphorylated downstream of MAPK signaling and is acetylated at lysines 33 and 116 by the histone acetyltransferase p300. BRD32048 is an inhibitor of the ETV1 transcription factor oncoprotein. BRD32048 binds ETV1 directly, modulating both ETV1-mediated transcriptional activity and invasion of ETV1-driven cancer cells. BRD32048 is a substituted [1,3,5]triazine derivative that inhibits ETV1 transcriptional activity by binding to ETV1 with KD of 17.1 μM, which reduces p300-dependent acetylation and stability of ETV1. Synonyms: BRD-32048; BRD 32048. Grades: ≥98%. CAS No. 433694-46-3. Molecular formula: C16H22N6O. Mole weight: 314.4.
CAY10669
P300/CBP-associated factor (PCAF), also known as K(lysine) acetyltransferase 2B (KAT2B), is a co-activator of p53-target genes and moreover it regulates p53 activity by acetylating K320, which promotes p53-dependent p21 transcription and cell cycle arrest during DNA damage. CAY10669 is an inhibitor of the histone acetyltransferase PCAF, which displays 2-fold improvement in inhibitory potency over anacardic acid. Synonyms: CAY 10669; CAY-10669. Grades: ≥98%. CAS No. 1243583-88-1. Molecular formula: C20H22O4. Mole weight: 326.4.
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