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5-[N-(2-Aminoethyl)-3-E-acrylamido]-2'-deoxy-5'-O-DMT-uridine is a modified form of uridine utilized in the biomedical industry. It plays a crucial role in drug research and development, particularly in addressing viral infections and genetic diseases. Synonyms: 5-[N-(2-Aminoethyl)-3-E-acrylamido]-2'-deoxy-5'-O-DMT-D-uridine; 5-[N-(2-Aminoethyl)-3-E-acrylamido]-5'-O-DMT-2'-deoxyuridine. Molecular formula: C35H38N4O8. Mole weight: 642.72.
5-[N-(2-Aminoethyl)-3-(E)-acrylamido]-5'-O-(dimethoxytrityl)-2'-deoxyuridine is an indispensable compound serving as a foundational unit for the fabrication of altered oligonucleotides. These synthetic genetic constructs spearhead unparalleled developments in realms such as gene therapy and nucleic acid-oriented diagnostics. Synonyms: 5-[3-(2-Aminoethylamino)-3-oxo-1-propenyl]-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine; (E)-N-(2-Aminoethyl)-3-[1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxyoxolan-2-yl]-2,4-dioxopyrimidin-5-yl]prop-2-enamide. Grades: 95%. CAS No. 606126-32-3. Molecular formula: C35H38N4O8. Mole weight: 642.72.
5-[N(2-(Trifluoroacetamido)ethyl)-3-(E)-acrylamido]-2'-deoxyuridine is a potent anti-cancer compound with the ability to inhibit DNA enhancement. This compound facilitates the research of diseases such as leukemia, breast cancer and lung cancer by impeding tumor growth and promoting cell death. Synonyms: (E)-3-[1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2,4-dioxopyrimidin-5-yl]-N-[2-[(2,2,2-trifluoroacetyl)amino]ethyl]prop-2-enamide. Grades: 95%. CAS No. 869222-69-5. Molecular formula: C16H19F3N4O7. Mole weight: 436.36.
5-[N-(6-Aminohexyl)-3-(E)-acrylamido]-5'-O-(dimethoxytrityl)-2'-deoxyuridine is a pivotal constituent showcasing potent antiviral attributes targeting an array of DNA as well as RNA viruses. This invaluable substance finding application in the research and development of medicinal remedies aiming to combat viral afflictions such as herpes simplex virus (HSV) and human immunodeficiency virus (HIV). Synonyms: 5'-DMT-5-aha-dU; 5'-DMT-5-[N-(6-Aminohexyl)-3-E-acrylamido]-2'-deoxyuridine; 5-[3-[(6-Aminohexyl)amino]-3-oxo-1-propenyl]-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxyuridine; 5-[N-(6-Aminohexyl)-3-E-acrylamido]-2'-deoxy-5'-O-DMT-uridine; 5-[3-(6-Aminohexylamino)-3-oxo-1-propenyl]-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine; 5'-DMT-5-aha-2'-deoxyuridine. Grades: ≥98% by HPLC. CAS No. 252337-60-3. Molecular formula: C39H46N4O8. Mole weight: 698.82.
5-[N-(6-(Trifluoroacetamido)hexyl)-(E)-acrylamido]uridine is a highly intricate compound with antiviral capability, presenting itself as a potent research option for prevailing viral infections like influenza, hepatitis C is and respiratory syncytial virus. Synonyms: 5-[3-OXO-3-[[6-[TRIFLUORACETYLAMINO]HEXYL]AMINO]-1-PROPENYL]URIDINE. CAS No. 869222-70-8. Molecular formula: C20H27F3N4. Mole weight: 508.46.
5-[N(6-(Trifluoroacetamido)hexyl)-3-(E)-acrylamido]-2'-deoxyuridine, known for its potent antiviral properties, has become a pivotal component in research of combatting viral infections induced by herpes simplex viruses (HSV). Functionally, it obtrudes viral DNA replication by inducing chain termination throughout the process of viral DNA research and development. Synonyms: 5-TFA-aha-2'-deoxyuridine; TFA-aha-dU; 2'-Deoxy-5-[3-oxo-3-[[6-[(trifluoroacetyl)amino]hexyl]amino]-1-propenyl]-uridine; 5-TFA-aha-dU; uridine, 2'-deoxy-5-[3-oxo-3-[[6-[(trifluoroacetyl)amino]hexyl]amino]-1-propenyl]-; (E)-3-(1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-N-(6-(2,2,2-trifluoroacetamido)hexyl)acrylamide. Grades: ≥98% by HPLC. CAS No. 252337-58-9. Molecular formula: C20H27F3N4O. Mole weight: 396.45.
5'-O-(Dimethoxytrityl)-5-[N-(2-(trifluoroacetamido)ethyl)-3-(E)acrylamido]-2'-deoxyuridine is a crucial compound in biomedicine used for the development of antiviral drugs. With its unique chemical structure, it exhibits activity against a variety of viral infections, including DNA viruses, RNA viruses, and retroviruses. This product plays a pivotal role in the synthesis of potent antiviral medication, contributing to the treatment and prevention of numerous viral diseases. Synonyms: (E)-3-[1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxyoxolan-2-yl]-2,4-dioxopyrimidin-5-yl]-N-[2-[(2,2,2-trifluoroacetyl)amino]ethyl]prop-2-enamide; 5'-O-DMT-5-[N-(2-(trifluoroacetamido)ethyl)-3-E-acrylamido]-2'-deoxyuridine; 5/'-O-(DIMETHOXYTRITYL)-5-[N-(2-(TRIFLUOROACETAMIDO)ETHYL)-3-(E)-ACRYLAMIDO]-2/'-DEOXYURIDINE; (E)-3- (1- ( (2R, 4S, 5R)-5- ( (bis (4-methoxyphenyl) (phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-2, 4-dioxo-1, 2, 3, 4-tetrahydropyrimidin-5-yl)-N- (2- (2, 2, 2-trifluoroacetamido)ethyl)acrylamide; 5'-o-(Dimethoxytrityl)-5-[N-(2-(trifluoroacetamido)ethyl)-3-(E)-acrylamido]-2'-decxyuridine. Grades: ≥ 97%. CAS No. 153512-23-3. Molecular formula: C37H37F3N4O9. Mole weight: 738.73.
The 5'-O-(Dimethoxytrityl)-5-[N-(6-(trifluoroacetamido)hexyl)-3-(E)-acrylamido]-2'-deoxyuridine represents a pivotal compound utilized in the field of biomedicine due to its indispensable role in the synthesis and advancement of potential antiviral agents. By specifically targeting viral replication processes and crucial enzymes, this product exhibits considerable promise in the treatment of a diverse range of viral infections. Thus, it assumes a vital role in the progression of pharmaceutical research, offering prospective solutions for tackling various viral diseases with utmost efficacy. Synonyms: 5'-DMT-5-TFA-aha-2'-deoxyuridine; 5'-DMT-5-TFA-aha-dU; 5'-O-DMT-5-[N-(6-(trifluoroacetamido)hexyl)-3-E-acryamido]-2'-deoxyuridine; 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-5-[3-oxo-3-[[6-[(2,2,2-trifluoroacetyl)amino]hexyl]amino]-1-propen-1-yl]-Uridine; 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-deoxy-5-[(1E)-3-oxo-3-({6-[(trifluoroacetyl)amino]hexyl}amino)-1-propen-1-yl]uridine. Grades: ≥98% by HPLC. CAS No. 252337-59-0. Molecular formula: C41H45F3N4O9. Mole weight: 794.84.
A cell-permeable indolylacrylamido-benzamide compound that is reported to target Dnmt1 at the cofactor SAM-binding site and enhance the efficiency of iPSC production from both murine MEF (10uM starting 5 d post KSOM viral infection) and human foreskin fibroblast (10uM starting same day as or 5 d post KSOM viral infection) cultures with accompanying cellular Dnmt1 activity reduction, affecting hFF viability only at high concentrations (78% of control post 72h 100uM treatment). Also shown to help maintain H9 hESCs in undifferentiated state when cultured in unconditioned media (10uM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. Molecular Formula: C??H??N?O?, Primary Target: Dnmt1. US Biological Life Sciences.
A cell-permeable phenoxyacrylamido compound that inhibits hypoxia-induced cellular HIF-1alpha accumulation in a manner similar to LW6 by upregulating Hippel-Lindau tumor suppressor gene product pVHL, but with much higher potency (IC50 = 120nM vs 2.44uM, respectively, against hypoxia-induced HRE reporter activity in HCT116 cells). Shown to suppress HIF-1 target genes expression in HCT116 cultures and inhibit HUVEC tubule formation (effective conc. ≥2uM) under hypoxia conditions. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
Methyl Acrylamidoglycolate Methyl Ester
Methyl Acrylamidoglycolate Methyl Ester. Group: Biochemicals. Alternative Names: Methoxy[(1-oxo-2-propenyl)amino]acetic Acid Methyl Ester; MAGME; MAGME 100; Methyl Acrylamidoglycolate Methyl Ether. Grades: Highly Purified. CAS No. 77402-03-0. Pack Sizes: 500mg. Molecular Formula: C7H11NO4, Molecular Weight: 173.17. US Biological Life Sciences.
The hydrophilic polymer contains polar or charged functional groups, making it soluble in water. Uses: These water-soluble polymers are a major class of polymers that have a wide range of applications, such as in drug delivery, gene delivery, protein delivery, self-assembly, surface modification, and catalysis. Group: Biomaterials. Alternative Names: 2-Acrylamido-2-methylpropanesulfonic acid-acrylonitrile copolymer. CAS No. 54640-82-3. Molecular formula: C10H16N2O4S. Mole weight: 260.31g/mol. IUPACName: 2-methyl-2-(prop-2-enoylamino)propane-1-sulfonic acid;prop-2-enenitrile. Canonical SMILES: C=CC#N.CC(C)(CS(O)(=O)=O)NC(=O)C=C. Catalog: ACM54640823-1.
The hydrophilic polymer contains polar or charged functional groups, making it soluble in water. Uses: These water-soluble polymers are a major class of polymers that have a wide range of applications, such as in drug delivery, gene delivery, protein delivery, self-assembly, surface modification, and catalysis. Group: other plastics. Alternative Names: 2-Acrylamido-2-methylpropanesulfonic acid-acrylonitrile copolymer. CAS No. 54640-82-3. Product ID: 2-methyl-2-(prop-2-enoylamino)propane-1-sulfonic acid; prop-2-enenitrile. Molecular formula: 260.31g/mol. Mole weight: C10H16N2O4S. C=CC#N.CC(C)(CS(O)(=O)=O)NC(=O)C=C. InChI=1S/C7H13NO4S. C3H3N/c1-4-6(9)8-7(2, 3)5-13(10, 11)12; 1-2-3-4/h4H, 1, 5H2, 2-3H3, (H, 8, 9)(H, 10, 11, 12); 2H, 1H2. WXTSVBZXMYPBLC-UHFFFAOYSA-N.
The hydrophilic polymer contains polar or charged functional groups, making it soluble in water. Uses: Thickening agent for acidic or basic cleaning agents, friction reducing agent, water-based lubricant, mineral scale remover and suspension aid for pigments and fillers. rheology control agent in water and some organic solvents. Group: Hydrophilic polymersself-assembly materials. Alternative Names: PolyAMPS, 2-Acrylamido-2-methylpropanesulfonic acid polymer, 2-Acrylamido-2-methyl-1-propanesulfonic acid polymer. CAS No. 27119-07-9. Pack Sizes: Packaging 100, 250 g in glass bottle. Product ID: 2-methyl-2-(prop-2-enoylamino)propane-1-sulfonic acid. Molecular formula: average Mw 2,000,000. Mole weight: C7H13NO4S. CC(C)(CS(O)(=O)=O)NC(=O)C=C. 1S/C7H13NO4S/c1-4-6(9)8-7(2, 3)5-13(10, 11)12/h4H, 1, 5H2, 2-3H3, (H, 8, 9)(H, 10, 11, 12). XHZPRMZZQOIPDS-UHFFFAOYSA-N.
2-(Dimethylamino)ethyl acrylate
2-dimethylaminoethyl acrylate appears as a colorless to light yellow liquid with an acrid odor. Insoluble in water and floats on water. Irritates the eyes and produces tears.;Liquid. Uses: 2-(dimethylamino)ethyl acrylate (amac) are aminoacrylates. amac was used to fabricate gold/acrylic polymer nanocomposites.1 2-(dimethylamino)ethyl acrylate (daea) can undergo copolymerization with 2-acrylamido-2-methylpropanesulphonic acid (amps). Group: Monomers. CAS No. 2439-35-2. Pack Sizes: Packaging 100, 500 mL in glass bottle. Product ID: 2-(dimethylamino)ethyl prop-2-enoate. Molecular formula: 143.18. Mole weight: H2C=CHCO2CH2CH2N(CH3)2. CN(C)CCOC(=O)C=C. 1S/C7H13NO2/c1-4-7 (9)10-6-5-8 (2)3/h4H, 1, 5-6H2, 2-3H3. DPBJAVGHACCNRL-UHFFFAOYSA-N.
Avenanthramide-C methyl ester
Avenanthramide-C methyl ester is an inhibitor of NF-κB activation that acts by blocking the phosphorylation of IKK and IκB (IC50 = 40 μM). Synonyms: Avenanthramide-C methyl ester; 955382-52-2; methyl 2-[[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]amino]-5-hydroxybenzoate; SCHEMBL20963041; IUZHCICFVDHVMC-XVNBXDOJSA-N; AKOS040755114; Methyl (E)-2-(3-(3,4-dihydroxyphenyl)acrylamido)-5-hydroxybenzoate; 2-[[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]amino]5-hydroxy-benzoic acid, methyl ester; 2-[[(2E)-3-(3,4-Dihydroxyphenyl)-1-oxo-2-propen-1-yl]amino]5-hydroxybenzoic acid, methyl ester. Grades: ≥90%. CAS No. 955382-52-2. Molecular formula: C17H15NO6. Mole weight: 329.3.
Belinostat Glucuronide. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (2S, 3S, 4S, 5R, 6S) -3, 4, 5-trihydroxy-6- ( ( (E) -3- (3- (N-phenylsulfamoyl) phenyl) acrylamido) oxy) tetrahydro-2H-pyran-2-carboxylic acid. CAS No. 1486471-13-9. Molecular Formula: C21H22N2O10S. Mole Weight: 494.47. Catalog: APB1486471139.
Brostallicin
Brostallicin, a-bromo-acrylamido tetra-pyrrole derivative, is a second-generation minor groove binder (MGB) structurally related to distamycin A with potential antineoplastic activity. Compared with that of other minor groove binders, this agent appears to bind covalently to DNA in a different manner and its activity does not depend on a functional DNA mismatch repair (MMR) mechanism. Synonyms: 4-[[4-[[4-[[4-(2-bromoprop-2-enoylamino)-1-methylpyrrole-2-carbonyl]amino]-1-methylpyrrole-2-carbonyl]amino]-1-methylpyrrole-2-carbonyl]amino]-N-[2-(diaminomethylideneamino)ethyl]-1-methylpyrrole-2-carboxamide; brostallicin; PNU 166196; PNU-166196; PNU166196. Grades: >98%. CAS No. 203258-60-0. Molecular formula: C30H36BrClN12O5. Mole weight: 723.58.
CHMFL-BMX-078
CHMFL-BMX-078 is a highly potent and selective type II irreversible BMX kinase inhibitor that exhibits an IC50 of 11 nM against BMX kinase and exhibits great selectivity over kinases such as BTK, JAK3, EGFR, and MAP2K7 that bore a structurally identical cysteine residue in BMX kinase. Uses: Protein kinase inhibitors. Synonyms: CHMFL-BMX-078; CHMFL-BMX 078;CHMFL BMX 078; CHMFLBMX078; 4- (methylamino) -2-[4-methyl-3- (prop-2-enoylamino) anilino]-N-[2-methyl-5-[ (3, 4, 5-trimethoxybenzoyl) amino]phenyl]pyrimidine-5-carboxamide; 2-((3-acrylamido-4-methylphenyl)amino)-N-(2-methyl-5-(3,4,5-trimethoxybenzamido)phenyl)-4-(methylamino)pyrimidine-5-carboxamide. CAS No. 1808288-51-8. Molecular formula: C33H35N7O6. Mole weight: 625.67.
FA-Glu-Glu-OH
FA-Glu-Glu-OH is the preferred substrate for carboxypeptidase O in humans and zebrafish. Synonyms: N-[(2E)-3-(2-Furyl)-2-propenoyl]-L-α-glutamyl-L-glutamic acid; L-Glutamic acid, N-[(2E)-3-(2-furanyl)-1-oxo-2-propen-1-yl]-L-α-glutamyl-; (S) -2- ( (S) -4-carboxy-2- ( (E) -3- (furan-2-yl) acrylamido) butanamido) pentanedioic acid; FA-EE-OH. Grades: ≥90%. CAS No. 1374423-90-1. Molecular formula: C17H20N2O9. Mole weight: 396.35.
Synonyms: (E)-2-(3-(Furan-2-yl)acrylamido)acetic acid; Furanacryloylglycine; Fa Gly OH. Grades: 95%. CAS No. 124882-74-2. Molecular formula: C9H9NO4. Mole weight: 195.17.
FA-PHE-PHE-OH
A substrate for a sensitive spectrophotometric assay of serum carboxypeptidase A. Synonyms: N-(3-[2-Furyl]acryloyl)-Phe-Phe; FAPP; Furylacryloyl-Phe-Phe; (S)-2-((S)-2-((E)-3-(furan-2-yl)acrylamido)-3-phenylpropanamido)-3-phenylpropanoic acid. CAS No. 83661-95-4. Molecular formula: C25H24N2O5. Mole weight: 432.47.
Jh-X-119-01 is a novel potent and selective interleukin-1 receptor-associated kinases 1 (IRAK1) inhibitor. JH-X-119-01 irreversibly labels IRAK1 at C302. This compound exhibited cytotoxic activity at single digit micromolar concentrations in a panel of WM, DLBCL, and lymphoma cell lines expressing MYD88. Cotreatment of JH-X-119-01 with the BTK inhibitor ibrutinib resulted in synergistic killing effects in these systems. Group: Inhibitors. Alternative Names: JH-X-119-01; JH-X119-01; JH-X 119-01; JH-X-11901; JH-X11901; JH-X 11901; JHX-11901; JHX11901; JHX 11901. CAS No. 2227368-54-7. Molecular formula: C25H20N6O3. Mole weight: 452.47. Appearance: Solid powder. Purity: >98%. IUPACName: N-(4-(3-Acrylamidobenzamido)phenyl)-6-(1H-pyrazol-5-yl)picolinamide. Canonical SMILES: O=C (NC1=CC=C (NC (C2=CC=CC (NC (C=C)=O)=C2)=O)C=C1)C3=NC (C4=CC=NN4)=CC=C3. Catalog: ACM2227368547.
PD-168393
PD-168393 is a potent, cell-permeable, irreversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50 = 700 pM). It is effective in vivo, suppressing the growth of human epidermoid carcinoma xenografts in mice. Synonyms: 4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline; PD168393; PD 168393; PD-168393. CAS No. 194423-15-9. Molecular formula: C17H13BrN4O. Mole weight: 369.222.
PLS-123
PLS-123 is a novel covalent irreversible Bruton's Tyrosine Kinase inhibitor. PLS-123 shows potent anti-proliferative effects in multiple cellular and in vivo preclinical models of B-cell lineage malignancy. PLS-123 may become a drug candidate for treatment of B cell cancers. Uses: B cell cancers. Synonyms: PLS-123; PLS 123; PLS123. N- (2- ( (3- (2-acrylamidoacetamido) phenyl) amino) pyrimidin-5-yl) -2-methyl-5- (3- (trifluoromethyl) benzamido) benzamide. Grades: 98%. CAS No. 1431727-04-6. Molecular formula: C31H26F3N7O4. Mole weight: 617.59.
S-Bz-Thiol-Modifier C6-dT
S-Bz-Thiol-Modifier C6-dT is a complex yet valuable biochemical agent utilized in the modification and labeling of nucleic acids. With its versatile combination of a benzylthiol group and a C6 modification, it has become an essential component in the preparation of oligonucleotides and the analysis of DNA-protein interactions. Its potential applications extend to the fields of genetic disorders and cancer research. For researchers seeking to probe and understand genetic mechanisms with precision and accuracy, S-Bz-Thiol-Modifier C6-dT stands out as an indispensable tool. Synonyms: 5'-(4,4'-Dimethoxytrityl)-5-[N-(6-(3-benzoylthiopropanoyl)-aminohexyl)-3-acrylamido]-2'-deoxyuridine, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite. Molecular formula: C58H71N6O11PS. Mole weight: 1091.26.
Tributylmethylammonium methyl carbonate solution
Tributylmethylammonium methyl carbonate can be used in the preparation of counter-cation anionic monomers by reacting with 2-acrylamido-2- methylpropanesulfonic acid and acrylic acid. Uses: Cas: 274257-37-3, mf: c15h33no3, mw: 275.43. Group: Electrolytes. Alternative Names: Methyltributyl Ammonium methylcarbonate. CAS No. 274257-37-3. Product ID: methyl carbonate; tributyl(methyl)azanium. Molecular formula: 275.43. Mole weight: Linear Formula (CH3CH2CH2CH2)3N(Cl)CH3. CCCC[N+](C)(CCCC)CCCC.COC(=O)[O-]. 1S/C13H30N.C2H4O3/c1-5-8-11-14(4, 12-9-6-2)13-10-7-3; 1-5-2(3)4/h5-13H2, 1-4H3; 1H3, (H, 3, 4)/q+1; /p-1. ZKWSMHMGQLTZGI-UHFFFAOYSA-M. ~50%inmethanol:water(2:3).
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