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AdenosineDeaminase (also known as adenosine aminohydrolase, or ADA) is an enzyme (EC 3.5.4.4) involved in purine metabolism. It is needed for the breakdown of adenosine from food and for the turnover of nucleic acids in tissues. Group: Enzymes. Synonyms: deoxyadenosinedeaminase. Enzyme Commission Number: EC 3.5.4.4. CAS No. 9026-93-1. ADA. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4568; adenosinedeaminase; EC 3.5.4.4; 9026-93-1; deoxyadenosinedeaminase. Cat No: EXWM-4568.
Adenosinedeaminase Bovine, Recombinant
Adenosinedeaminase is an enzyme (EC 3.5.4.4) involved in purine metabolism. It is needed for the breakdown of adenosine from food and for the turnover of nucleic acids in tissues. Present in virtually all mammalian cells, its primary function in Humans is the development and maintenance of the immune system. Protein determined by biuret. Applications: Adenosinedeaminase is useful in various molecular biology assays, such as glycerol release assays. adenosinedeaminase is a potential target for treatments of combined immunodeficiency disease. Group: Enzymes. Synonyms: ADA; adenosinedeaminase; adenosine aminohydrolase; 9026-93-1; EC 3.5.4.4. Enzyme Commission Number: EC 3.5.4.4. CAS No. 9026-93-1. ADA. Mole weight: 32.5-33 kDa. Activity: 60-130 units/mg protein; > 130 units/mg protein; 150-200 units/mg protein. Storage: 2-8°C. Form: ammonium sulfate suspension. Suspension in 3.2 M (NH4)2SO4, 0.01 M potassium phosphate, pH 6.0. Source: E. coli. Species: Bovine. ADA; adenosinedeaminase; adenosine aminohydrolase; 9026-93-1; EC 3.5.4.4. Cat No: NATE-0032.
Adenosinedeaminase from Human, Recombinant
Adenosinedeaminase is an enzyme (EC 3.5.4.4) involved in purine metabolism. It is needed for the breakdown of adenosine from food and for the turnover of nucleic acids in tissues. Present in virtually all mammalian cells, its primary function in Humans is the development and maintenance of the immune system. Applications: Adenosinedeaminase (ada) is a key enzyme in purine metabolism and is essential for normal immune function. it is important in the study of immune system diseases such as rheumatoid arthritis. Group: Enzymes. Synonyms: ADA; adenosinedeaminase; adenosine aminohydrolase; 9026-93-1; EC 3.5.4.4. Enzyme Commission Number: EC 3.5.4.4. CAS No. 9026-93-1. ADA. Activity: >1 U/mL. Storage: Store at -20°C. Source: E. coli. Species: Human. ADA; adenosinedeaminase; adenosine aminohydrolase; 9026-93-1; EC 3.5.4.4. Cat No: NATE-1583.
Adenosinedeaminase, microorganism
Adenosinedeaminase (RnADA) (EC 3.5.4.4) is an enzyme that catalyzes the irreversible deamination of adenosine and 2'-deoxyadenosine to inosine and 2'-deoxyinosine, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RnADA. CAS No. 9026-93-1. Pack Sizes: 1 mg. Product ID: HY-114175.
Adenosinedeaminase, Recombinant
Adenosinedeaminase is an enzyme (EC 3.5.4.4) involved in purine metabolism. It is needed for the breakdown of adenosine from food and for the turnover of nucleic acids in tissues. Present in virtually all mammalian cells, its primary function in Humans is the development and maintenance of the immune system. Group: Enzymes. Synonyms: ADA; adenosinedeaminase; adenosine aminohydrolase; 9026-93-1; EC 3.5.4.4. Enzyme Commission Number: EC 3.5.4.4. CAS No. 9026-93-1. Purity: > 90 %. ADA. Mole weight: About 53kDa (SDS-PAGE). Activity: 200U/mg protein. Appearance: White powder, lyophilized. Storage: Redissolved in 20% glycerol, 4°C, store at -20°C for long-term preservation, Avoid multiple freeze-thaw cycles. Source: E. coli. ADA; adenosinedeaminase; adenosine aminohydrolase; 9026-93-1; EC 3.5.4.4. Cat No: NATE-1009.
ADAR1, Inhibitor Peptide (AdenosineDeaminases Acting on RNA 1)
The mammalian AdenosineDeaminases Acting on RNA (ADAR) constitute a family of sequence-related proteins involved in pre-mRNA editing of nuclear transcripts through site-speci?c adenosine modi?cation. ADARs are not active on adenosine-mononucleotide and are only distantly related by sequence to adenosine and AMP deaminases involved in purine metabolism. The ADARs convert certain adenosine bases in an RNA transcript into inosines by removing an amino group involved in Watson-Crick base pairing. The ADARs recognize a double stranded RNA (dsRNA) structure in the transcript that is formed between the editing site complementary sequence (ECS), usually located in the downstream 3 intron of the transcript, and the sequence to be edited. Group: Molecular Biology. Grades: Purified. Pack Sizes: 100ug. US Biological Life Sciences.
Worldwide
adenosine-phosphate deaminase
Acts on AMP, ADP, ATP, NAD+ and adenosine, in decreasing order of activity. The bacterial enzyme can also accept the deoxy derivatives. cf. EC 3.5.4.6, AMP deaminase. Group: Enzymes. Synonyms: adenylate deaminase; adenine nucleotide deaminase; adenosine (phosphate) deaminase. Enzyme Commission Number: EC 3.5.4.17. CAS No. 37289-20-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4543; adenosine-phosphate deaminase; EC 3.5.4.17; 37289-20-6; adenylate deaminase; adenine nucleotide deaminase; adenosine (phosphate) deaminase. Cat No: EXWM-4543.
EHNA Hydrochloride (NSC263164, EHNA HCl, Adenosinedeaminase inhibitor, 9H-Purine-9-ethanol, monohydrochloride). Group: Biochemicals. Alternative Names: (2S,3R)-3-(6-aminopurin-9-yl)nonan-2-ol;hydrochloride. Grades: Highly Purified. CAS No. 58337-38-5. Pack Sizes: 25mg. Molecular Formula: C14 H23 N5, Molecular Weight: 313.8. US Biological Life Sciences.
Worldwide
Native Calf AdenosineDeaminase
Adenosinedeaminase is an enzyme (EC 3.5.4.4) involved in purine metabolism. It is needed for the breakdown of adenosine from food and for the turnover of nucleic acids in tissues. Present in virtually all mammalian cells, its primary function in Humans is the development and maintenance of the immune system. Group: Enzymes. Synonyms: ADA; adenosinedeaminase; adenosine aminohydrolase; 9026-93-1; EC 3.5.4.4. Enzyme Commission Number: EC 3.5.4.4. CAS No. 9026-93-1. ADA. Mole weight: 33 kDa (SDS-PAGE). Activity: 150~200U/mg protein. Storage: Storage: Temperature 2-8 centigrade. Source: Calf Spleen. Species: Calf. ADA; adenosinedeaminase; adenosine aminohydrolase; 9026-93-1; EC 3.5.4.4. Cat No: DIA-271.
Pentostatin, AdenosineDeaminase Inhibitor, DCF (2-Deoxycoformycin, Pentostatin, S. antibioticus, (8R)-3-(2-deoxy-b-D-erythro- pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol)
A cell-permeable purine nucleoside compound that acts as a highly potent, tight binding transition state analog inhibitor of adenosinedeaminase (ADA; Ki=2.5pM against partially purified human erythrocytes, and 0.48 to 9.1nM against rat liver, rat intestine, rat hepatoma and human B cells). Reported to be an immunomodulator and exert selective toxicity towards lymphocytes. Group: Biochemicals. Grades: Highly Purified. CAS No. 53910-25-1. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?, Molecular Weight: 268.3. US Biological Life Sciences.
Worldwide
Recombinant Adenosinedeaminase from Pseudomonas aeruginosa
Adenosinedeaminase is an enzyme (EC 3.5.4.4) involved in purine metabolism. It is needed for the breakdown of adenosine from food and for the turnover of nucleic acids in tissues. Present in virtually all mammalian cells, its primary function in Humans is the development and maintenance of the immune system. Group: Enzymes. Synonyms: ADA; adenosinedeaminase; adenosine aminohydrolase; 9026-93-1; EC 3.5.4.4. Enzyme Commission Number: EC 3.5.4.4. Purity: > 80 %. ADA. Mole weight: 36 kDa. Appearance: Colourless clear liquid. Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Source: E. coli. Species: Pseudomonas aeruginosa. ADA; adenosinedeaminase; adenosine aminohydrolase; 9026-93-1; EC 3.5.4.4. Cat No: NATE-1010.
S-methyl-5'-thioadenosinedeaminase
The enzyme from Thermotoga maritima also functions as S-adenosylhomocysteine deaminase (EC 3.5.4.28) and has some activity against adenosine. Adenosine 5'-phosphate and S-adenosyl-L-methionine (SAM) are not substrates. Group: Enzymes. Synonyms: MTA deaminase; 5-methylthioadenosinedeaminase. Enzyme Commission Number: EC 3.5.4.31. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4559; S-methyl-5'-thioadenosinedeaminase; EC 3.5.4.31; MTA deaminase; 5-methylthioadenosinedeaminase. Cat No: EXWM-4559.
1-(8-Phosphonooctyl)-7-deazaxanthine
1-(8-Phosphonooctyl)-7-deazaxanthine is a potent adenosinedeaminase antagonist, adeptly used in immune response research. Synonyms: TP65; [8-(2,3,4,7-Tetrahydro-2,4-dioxo-1H-pyrrolo[2,3-d]?pyrimidin-1-yl)octyl]?phosphonic acid. CAS No. 405554-96-3. Molecular formula: C14H22N3O5P. Mole weight: 343.32.
1-Deazaadenosine
1-Deazaadenosine is an adenosinedeaminase inhibitor and has been found to show antitumor activity in some leukemia cell lines. Synonyms: 3-β-D-Ribofuranosyl-3H-imidazo[4,5-b]pyridin-7-amine. Grades: ≥98% by HPLC. CAS No. 14432-09-8. Molecular formula: C11H14N4O4. Mole weight: 266.25.
1-Deazaadenosine
1-Deazaadenosine is a potent Adenosinedeaminase (ADA) inhibitor with a K i value of 0.66 μM. 1-Deazaadenosine exhibits anti-cancer activities in vitro and has the potential to be a chemotherapy agent for lymphoproliferative disorders [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 14432-09-8. Pack Sizes: 1 mg. Product ID: HY-103159.
1-Deazaadenosine
Inhibitor of adenosinedeaminase (Ki = 0.66uM). Demonstrates antitumor activity in a range of leukemia cell lines. Group: Biochemicals. Grades: Highly Purified. CAS No. 14432-09-8. Pack Sizes: 10mg. Molecular Formula: C11H14N4O4. US Biological Life Sciences.
2-Amino-1-benzyl-9-((2R,3R,4S,5R)-3-hydroxy-5-(hydroxymethyl)-4-methoxytetrahydrofuran-2-yl)-1,9-dihydro-6H-purin-6-one plays a role in the biomedical industry by being a potential inhibitor of human adenosinedeaminase (ADA). Synonyms: 2-amino-1-benzyl-9-((2R,3R,4S,5R)-3-hydroxy-5-(hydroxymethyl)-4-methoxytetrahydrofuran-2-yl)-1,9-Dihydro-6H-purine-6-one. Molecular formula: C18H21N5O5. Mole weight: 387.39.
2-Chloro-N-[(3-iodophenyl)methyl]-2',3'-O-(1-methylethylidene) Adenosine, a potent inhibitor of adenosinedeaminase, exhibits anti-inflammatory and antitumor activity. Its use in research probes underexplored mechanisms that underlie various clinical conditions, and its therapeutic prospects extend to treating autoimmune disorders and cancers. Synonyms: [(3aR,4R,6R,6aR)-4-[2-chloro-6-[(3-iodophenyl)methylamino]purin-9-yl]-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]methanol; 2-Chloro-N-[(3-iodophenyl)methyl]-2',3'-O-(1-methylethylidene)Adenosine; [(3aR,4R,6R,6aR)-6-(2-chloro-6-{[(3-iodophenyl)methyl]amino}-9H-purin-9-yl)-2,2-dimethyl-tetrahydro-2H-furo[3,4-d][1,3]dioxol-4-yl]methanol. CAS No. 1000980-71-1. Molecular formula: C20H21ClIN5O4. Mole weight: 557.77.
2'-Deoxy-2-hydrazinoadenosine
2'-Deoxy-2-hydrazinoadenosine, a prominent pharmaceutical compound in the biomedical field, emerges as a paramount player in research of combating select cancer manifestations. Its pivotal role as an adenosinedeaminase inhibitor engenders a cascade of effects that intricately modulate adenosine metabolism. As this intricate enzyme's activity is thwarted, cancer cells face an imminent demise, rendering this compound an efficacious therapeutic choice for targeted malignancies. Synonyms: 2-hydrazino-2'-deoxy-adenosine; (2R,3S,5R)-5-(6-Amino-2-hydrazinyl-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol. Grades: ≥95%. CAS No. 1000296-26-3. Molecular formula: C10H15N7O3. Mole weight: 281.27.
2'-O-Methyladenosine
2'-O-Methyladenosine, a methylated adenine residue is found in urine of normals as well as in urine of adenosinedeaminase (ADA) deficient patients. 2'-O-Methyladenosine exhibits unique hypotensive activities [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 2140-79-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W011552.
3-(2-Propenyl)adenine
9-(2-Propenyl)adenine is an N-substituted purine with DNA binding potential and cancer-initiating effect. 3-(2-Propenyl)adenine is a noncompetitive inhibitor of nonspecific adenosinedeaminase from Taka-Diastase. Group: Biochemicals. Alternative Names: 3-Allyladenine; 3-(2-Propen-1-yl)-3H-purin-6-amine; NSC 145068. Grades: Highly Purified. CAS No. 13532-34-8. Pack Sizes: 10mg. US Biological Life Sciences.
(3S,4S,5R)-6-(6-Amino-2-chloro-9H-purin-9-yl)-5-fluorotetrahydro-2H-pyran-3,4-diol is an impurity of Clofarabine, Second generation purine nucleoside analog, antimetabolite that inhibits DNA synthesis and resists deamination by adenosinedeaminase. Antineoplastic. Synonyms: Clofarabine Impurity. Molecular formula: C10H11ClFN5O3. Mole weight: 303.68.
5'-Biotin-A-Monophosphate
5'-Biotin-A-Monophosphate, a biomedicine product, serves as an essential substrate for the enzyme adenosinedeaminase. It enables the comprehensive study of adenosine metabolism in various tissues and cells. Apart from this, 5'-Biotin-A-Monophosphate is an effective tool in developing diagnostic kits for adenosinedeaminase deficiency and equally monitoring the progress of enzyme replacement therapy. Synonyms: 5'-Biotin-AMP. Grades: ≥90% by AX-HPLC. Molecular formula: C26H41N8O9PS. Mole weight: 672.70.
6-Amino-2-chloro-9-(2'-deoxy-2-fluoro-3',5'-di-O-benzoyl-β-D-arabinofuranosyl)-9H-purine is an intermediate in the synthesis of N-[4-Amino-2-chloro-6-[(2-deoxy-2-fluoro-β-D-arabinopyranosyl)amino]-5-pyrimidinyl]-formamide which is a clofarabine related compound. Clofarabine is a second generation purine nucleoside analog, and antimetabolite that inhibits DNA synthesis and resists deamination by adenosinedeaminase. Antineoplastic. Synonyms: 2-Chloro-9-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine. CAS No. 355138-50-0. Molecular formula: C24H19ClFN5O5. Mole weight: 511.89.
6-Chloropurine-9-ß-D-ribofuranoside
A substrate for adenosinedeaminase. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10g. US Biological Life Sciences.
Worldwide
6-Chloropurine Riboside
It is an adenosinedeaminase substrate. Synonyms: 6-Chloro-9-(beta-D-ribofuranosyl)purine; 6-chloroinosine; 6-Chloropurine-9-β-D-ribofuranoside; 6-Chloro-6-deaminoadenosine; 6-Chloro-9-β-D-ribofuranosyl-9H-purine; 6-Chloro-9-β-D-ribofuranosylpurine; 6-Chloronebularine; 6-Chloropurine-D-riboside; 6-Chloropurinosine; 9-(β-D-Ribofuranosyl)-6-chloropurine; NSC 4910. Grades: ≥ 98 % by HPLC. CAS No. 5399-87-1. Molecular formula: C10H11ClN4O4. Mole weight: 286.67.
A substrate for adenosinedeaminase. Group: Biochemicals. Alternative Names: 6-Thio-9-b-D-ribofuranoside6-Thioinosine. Grades: Highly Purified. Pack Sizes: 1g. US Biological Life Sciences.
2',3',5'-Triacetate derivative of 6-Mercaptopurine-9-β-D-ribofuranoside, a substrate for adenosinedeaminase. Synonyms: 9-β-D-ribofuranosyl-9H-purine-6-thiol 2',3',5'-Triacetate; 6-Thioinosine 2',3',5'-triacetate; NSC 66385; (2R,3R,4R,5R)-2-(Acetoxymethyl)-5-(6-mercapto-9H-purin-9-yl)tetrahydrofuran-3,4-diyl Diacetate. CAS No. 3021-21-4. Molecular formula: C16H18N4O7S. Mole weight: 410.4.
6-Mercaptopurine Riboside
A substrate for adenosinedeaminase. Uses: Antimetabolites, antineoplastic. Synonyms: 6-Thioinosine; Ribosyl-6-thiopurine; 6-Thio-9-β-D-ribofuranoside6-Thioinosine. Grades: 90%. CAS No. 574-25-4. Molecular formula: C10H12N4O4S. Mole weight: 284.29.
Adechlorin
Adechlorin is a nucleoside compound produced from Actinomadura sp. OMR-37. Adechlorin, a new adenosinedeaminase inhibitor containing chlorine production, isolation and properties. Synonyms: 2'-Chloropentostatin; 2'-Cldcf; 2'-Chloro-2'-deoxycoformycin. Grades: >98%. CAS No. 96328-17-5. Molecular formula: C11H15ClN4O4. Mole weight: 302.71.
Adecypenol
Adecypenol is an adenosinedeaminase inhibitor produced from Streptomyces sp. OM-3223. Synonyms: Antibiotic OM 3223; 3-Cyclopentene-1,2-diol, 5-(7,8-dihydro-8-hydroxyimidazo(4,5-d)(1,3)diazepin-3(4H)-yl)-3-(hydroxymethyl)-. Grades: >98%. CAS No. 104493-13-2. Molecular formula: C12H16N4O4. Mole weight: 280.28.
Adenosine 2',3'-cyclic phosphate sodium
Adenosine 2',3'-cyclic phosphate sodium is a 2',3'-cyclic purine nucleotide. Adenosine 2',3'-cyclic phosphate sodium is deaminated by the adenosinedeaminase. Adenosine 2',3'-cyclic phosphate sodium can be degrade to 2'-AMP and 3'-AMP [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 37063-35-7. Pack Sizes: 5 mg. Product ID: HY-W011256.
ADP deaminase
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. Group: Enzymes. Synonyms: adenosine diphosphate deaminase; adenosinepyrophosphate deaminase. Enzyme Commission Number: EC 3.5.4.7. CAS No. 9027-79-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4575; ADP deaminase; EC 3.5.4.7; 9027-79-6; adenosine diphosphate deaminase; adenosinepyrophosphate deaminase. Cat No: EXWM-4575.
α-Clofarabine
α-Clofarabine is a second generation purine nucleoside analog; antimetabolite that inhibits DNA synthesis and resists deamination by adenosinedeaminase. Antineoplastic. Synonyms: 2-Chloro-9-(2-deoxy-2-fluoro-α-D-arabinofuranosyl)-9H-purin-6-amine. CAS No. 491594-60-6. Molecular formula: C10H11ClFN5O3. Mole weight: 303.68.
AMP deaminase
cf. EC 3.5.4.17 adenosine-phosphate deaminase. Group: Enzymes. Synonyms: adenylic acid deaminase; AMP aminase; adenylic deaminase; adenylate deaminase; 5-AMP deaminase; adenosine 5-monophosphate deaminase; 5-adenylate deaminase; adenyl deaminase; 5-adenylic acid deaminase; adenosine monophosphate deaminase; adenylate aminohydrolase; adenylate desaminase; adenosine 5-phosphate aminohydrolase; 5-adenylate deaminase. Enzyme Commission Number: EC 3.5.4.6. CAS No. 9025-10-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4574; AMP deaminase; EC 3.5.4.6; 9025-10-9; adenylic acid deaminase; AMP aminase; adenylic deaminase; adenylate deaminase; 5-AMP deaminase; adenosine 5-monophosphate deaminase; 5-adenylate deaminase; adenyl deaminase; 5-adenylic acid deaminase; adenosine monophosphate deaminase; adenylate aminohydrolase; adenylate desaminase; adenosine 5-phosphate aminohydrolase; 5-adenylate deaminase. Cat No: EXWM-4574.
ATP deaminase
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. Group: Enzymes. Synonyms: adenosine triphosphate deaminase. Enzyme Commission Number: EC 3.5.4.18. CAS No. 37289-21-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4544; ATP deaminase; EC 3.5.4.18; 37289-21-7; adenosine triphosphate deaminase. Cat No: EXWM-4544.
Cladribine
Cladribine (2-Chloro-2-deoxyadenosine), a purine nucleoside analog, is an orally active adenosinedeaminase inhibitor. Cladribine functions as an inhibitor of DNA synthesis to block the repair of the damaged DNA. Cladribine can inhibit DNA methylation. Cladribine has anti-lymphoma activity. Cladribine can be used for the research of several hematologic malignancies and multiple sclerosis [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 2-Chloro-2-deoxyadenosine; CldAdo; 2CdA. CAS No. 4291-63-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13599.
ISecond generation purine nucleoside analog; antimetabolite that inhibits DNA synthesis and resists deamination by adenosinedeaminase. Antineoplastic. Group: Biochemicals. Alternative Names: 2-Chloro-9-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)-9H-purin-6-amine; Clolar. Grades: Highly Purified. CAS No. 123318-82-1. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
Coformycin
Coformycin is a potent inhibitor of adenosinedeaminase (ADA) from Streptomyces species. Coformycin possesses anti-tumor and anti-bacterial activity. Synonyms: (R)-3,4,7,8-Tetrahydro-3-beta-D-ribofuranosylimidazo(4,5-d)(1,3)diazepin-8-ol; (8R)-3-beta-D-ribofuranosyl-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol. Grades: 98%. CAS No. 11033-22-0. Molecular formula: C11H16N4O5. Mole weight: 284.27.
double-stranded RNA adenine deaminase
This eukaryotic enzyme is involved in RNA editing. It destabilizes double-stranded RNA through conversion of adenosine to inosine. Inositol hexakisphosphate is required for activity. Group: Enzymes. Synonyms: ADAR; double-stranded RNA adenosinedeaminase; dsRAD; dsRNA adenosinedeaminase; DRADA1; double-stranded RNA-specific adenosinedeaminase. Enzyme Commission Number: EC 3.5.4.37. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4565; double-stranded RNA adenine deaminase; EC 3.5.4.37; ADAR; double-stranded RNA adenosinedeaminase; dsRAD; dsRNA adenosinedeaminase; DRADA1; double-stranded RNA-specific adenosinedeaminase. Cat No: EXWM-4565.
EHNA hydrochloride
EHNA hydrochloride is a potent and selective dual inhibitor of cyclic nucleotide phosphodiesterase 2 (PDE2) ( IC 50 =4 μM) and adenosinedeaminase (ADA). EHNA hydrochloride exerts a concentration inhibition of the cGMP-stimulated PDE II (cGs-PDE)( IC 50 :0.8 μM (human), 2 μM (porcine myocardium)), but has smaller inhibitory effect on the unstimulated PDE2 activity. EHNA hydrochloride play roles in mediating diverse pharmacological responses, including antiviral, antitumour and antiarrhythmic effects [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 58337-38-5. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg. Product ID: HY-103160A.
EHNA hydrochloride
EHNA hydrochloride is a selective inhibitor of cGMP-stimulated phosphodiesterase (PDE2) (IC50 = 0.8 - 4 μM) and also an inhibitor of adenosinedeaminase. EHNA inhibits spontaneous differentiation of human ESCs in feeder-free conditions and directed neuronal differentiation. Uses: Antiviral agents. Synonyms: (2S,3R)-3-(6-aminopurin-9-yl)nonan-2-ol hydrochloride. Grades: >98%. CAS No. 58337-38-5. Molecular formula: C14H23N5O.HCl. Mole weight: 313.83.
Ethyl trans-4-Aminocyclohexane carboxylate is a cyclohexane carboxylate amino isomer. Ethyl trans-4-Aminocyclohexane carboxylate is used in the synthesis of trans-4- (6-substituted-9-purinyl) cyclohexylcarbinols as inhibitors of adenosinedeaminase. Group: Biochemicals. Alternative Names: trans-4-Aminocyclohexane carboxylic Acid Ethyl Ester Hydrochloride; (trans-4-Carboethoxycyclohexyl) amine Hydrochloride. Grades: Highly Purified. CAS No. 2084-28-8. Pack Sizes: 50mg. US Biological Life Sciences.
Worldwide
Evodenoson
Evodenoson is a selective agonist of the A 2A adenosine receptor. Evodenosons primary actions include reducing inflammatory responses, decreasing intestinal fluid secretion, edema, tissue damage, and neutrophil infiltration induced by Clostridium difficile toxin A. Evodenosons protective effect is achieved by reducing myeloperoxidase (MPO) and adenosinedeaminase (ADA) activities, and by lowering the production of tumor necrosis factor-alpha (TNF-α) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ATL 313; DE 112. CAS No. 844873-47-8. Pack Sizes: 1 mg. Product ID: HY-105017.
Fludarabine-Cl
Fludarabine-Cl has an inhibitory effect on RNA adenosinedeaminase 1 ( ADAR1 ) with an IC 50 of 0.87 μM and can be used to prevent and/or study cancer or tumor-related diseases [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2734853-80-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-145443.
FR-221647
FR-221647 is a non-nucleoside adenosinedeaminase inhibitor. Synonyms: 1-(1-hydroxy-4-phenylbutan-2-yl)imidazole-4-carboxamide; FR-221647; FR 221647; FR221647. Grades: >98%. CAS No. 256461-28-6. Molecular formula: C14H17N3O2. Mole weight: 259.3.
FR-234938
FR-234938, with anti-inflammatory property, is a non-nucleoside recombinant human adenosinedeaminase enzyme inhibitor. Synonyms: 1-[(3R,4S)-4-hydroxy-1-naphthalen-1-ylpentan-3-yl]imidazole-4-carboxamide; FR-234938; FR 234938; FR234938. Grades: >98%. CAS No. 256461-79-7. Molecular formula: C19H21N3O2. Mole weight: 323.39.
Hibifolin
Hibifolin is a flavonol glycoside that prevents beta-amyloid-induced neurotoxicity in vitro. Hibifolin prevents beta-amyloid-induced neurotoxicity in cultured cortical neurons. Hibifolin is a potential inhibitor of adenosinedeaminase. Group: Inhibitors. Alternative Names: Hibifolin; Gossypetin 8-O-beta-D-glucuronide. CAS No. 55366-56-8. Molecular formula: C21H18O14. Mole weight: 494.36. Appearance: Solid powder. Purity: 0.99. IUPACName: beta-D-Glucopyranosiduronic acid, 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4-oxo-4H-1-benzopyran-8-yl. Canonical SMILES: O[C@H] ([C@H] ([C@@H] ([C@@H] (C (O)=O)O1)O)O)[C@@H]1OC2=C3C (C (C (O)=C (C4=CC=C (O)C (O)=C4)O3)=O)=C (O)C=C2O. Catalog: ACM55366568.
N-[4-Amino-2-chloro-6-[(2-deoxy-2-fluoro-α-D-arabinopyranosyl)amino]-5-pyrimidinyl]-formamide is a clofarabine related compound. Clofarabine is a second generation purine nucleoside analog, antimetabolite that inhibits DNA synthesis and resists deamination by adenosinedeaminase. Antineoplastic. Synonyms: N-[4-Amino-2-chloro-6-[(2-deoxy-2-fluoro-alpha-D-arabinopyranosyl)amino]-5-pyrimidinyl]-formamide; N-[4-Amino-2-chloro-6-[[(2S,3S,4R,5R)-3-fluoro-4,5-dihydroxyoxan-2-yl]amino]pyrimidin-5-yl]formamide. Grades: 95%. CAS No. 1140251-30-4. Molecular formula: C10H13ClFN5O4. Mole weight: 321.69.
N-[4-Amino-2-chloro-6-[(2-deoxy-2-fluoro-β-D-arabinopyranosyl)amino]-5-pyrimidinyl]-formamide is a clofarabine related compound. Clofarabine is a second generation purine nucleoside analog and antimetabolite that inhibits DNA synthesis and resists deamination by adenosinedeaminase. Antineoplastic. Synonyms: N-(4-Amino-2-chloro-6-(((2R,3S,4R,5R)-3-fluoro-4,5-dihydroxytetrahydro-2H-pyran-2-yl)amino)pyrimidin-5-yl)formamide. Grades: 95%. CAS No. 1140251-33-7. Molecular formula: C10H13ClFN5O4. Mole weight: 321.69.
N-[4-Amino-2-chloro-6-[(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)amino]-5-pyrimidinyl]-formamide is an intermediate in the synthesis of N-[4-Amino-2-chloro-6-[(2-deoxy-2-fluoro-β-D-arabinopyranosyl)amino]-5-pyrimidinyl]-formamide which is a clofarabine related compound. Clofarabine is a second generation purine nucleoside analog, antimetabolite that inhibits DNA synthesis and resists deamination by adenosinedeaminase. Antineoplastic. CAS No. 1140251-41-7. Molecular formula: C24H21ClFN5O6. Mole weight: 529.9.
N6-Lauroyl Cordycepin
A novel N6-substituted Cordycepin derivative; an adenosinedeaminase inhibitor. Group: Biochemicals. Alternative Names: 3'-Deoxy-N-(1-oxododecyl)adenosine. Grades: Highly Purified. CAS No. 77378-06-4. Pack Sizes: 1mg, 2mg, 5mg, 10mg. US Biological Life Sciences.
Worldwide
N6-Lauroyl Cordycepin
A novel N6-substituted Cordycepin derivative; an adenosinedeaminase inhibitor. Uses: A novel n6-substituted cordycepin derivative; an adenosinedeaminase inhibitor. Synonyms: 3'-Deoxy-N-(1-oxododecyl)adenosine. CAS No. 77378-06-4. Molecular formula: C22H35N5O4. Mole weight: 433.54.
N6-Propionyl Cordycepin
A novel N6-substituted Cordycepin derivative; an adenosinedeaminase inhibitor. Group: Biochemicals. Alternative Names: 3'-Deoxy-N-(1-oxopropyl)adenosine. Grades: Highly Purified. CAS No. 77378-04-2. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
N6-Propionyl Cordycepin
N6-Propionyl Cordycepin is a natural compound, originating from the formidable Cordyceps fungus. This compound emerges as a splendid modification of Cordycepin. It is used in studying the miseries associated with cancer, viral invasions and inflammation-induced disorders. Uses: A novel n6-substituted cordycepin derivative; an adenosinedeaminase inhibitor. Synonyms: 3'-Deoxy-N-(1-oxopropyl)adenosine. CAS No. 77378-04-2. Molecular formula: C13H17N5O4. Mole weight: 307.31.
Purine nucleoside phosphorylase (also known as PNPase) is an enzyme (EC 2.4.2.1) involved in purine metabolism. PNP metabolizes adenosine into adenine, inosine into hypoxanthine, and guanosine into guanine, in each case creating ribose phosphate. NP encodes the enzyme purine nucleoside phosphorylase that together with adenosinedeaminase (ADA) serves a key role in purine catabolism, referred to as the salvage pathway. Mutations in either enzyme result in a severe combined immunodeficiency (SCID). Confusingly, the same abbreviation (PNPase), is also used for another, otherwise unrelated, enzyme, namely Polynucleotide Phosphorylase. Purine nucleoside phosphorylase produced in microorganism has a molecular mass of 32 kda. Applications: Useful for enzymatic determination of inorganic phosphate. Group: Enzymes. Synonyms: inos. Enzyme Commission Number: EC 2.4.2.1. CAS No. 9030-21-1. PNPase. Activity: > 500U/mL. Appearance: Colourless to light brown solution. Storage: -20°C. Form: Liquid. Source: Bacillus sp. inosine phosphorylase; PNPase; PUNPI; PUNPII; inosine-guanosine phosphorylase; nucleotide phosphatase; purine deoxynucleoside phosphorylase; purine deoxyribonucleoside phosphorylase; purine nucleoside phosphorylase; purine ribonucleoside phosphorylase; purine-nucleoside: phosphate ribosyltransferase; EC 2.4.2.1. Cat No: DIA-164.
Native Microbial Xanthine Oxidase
Xanthine oxidase is a molybdenum-containing enzyme that is found in the cytosol, and may be strongly inhibited by flavonoids. It plays a vital role in the metabolism of some drugs, as well as purines and pyrimidines. It is also known to be a biological source of reactive oxygen species. Xanthine oxidase was shown to be involved in the reduction of cytochrome c by the generation of superoxide anions following the oxidation of xanthine. These free radicals are responsible for reducing cytochrome c. Allopurinol is a synthetic drug show to inhibit xanthine oxidase. Applications: This enzyme is useful for enzymatic determination of inorganic phosphorus, 5?-nucleotidase and adenosinedeaminase when coupled with purine-nucleoside phosphorylase and uricase. Group: Enzymes. Synonyms: Xanthine oxidase; XO; xanthine oxidoreductase; EC 1.17. Enzyme Commission Number: EC 1.17.3.2. CAS No. 9002-17-9. XAO. Mole weight: mol wt ~160 kDa. Activity: > 7 units/mg solid. Storage: -20°C. Form: Lyophilized powder containing BSA and sodium glutamate as stabilizers. Source: Microbial. Xanthine oxidase; XO; xanthine oxidoreductase; EC 1.17.3.2; 9002-17-9; XOD; Xanthine:oxygen oxidoreductase; hypoxanthine oxidase; hypoxanthine:oxygen oxidoreductase; Schardinger enzyme; hypoxanthine-xanthine oxidase; xanthine:O2 oxidoreductase; xanthine:xanthine oxidase. Cat No: NATE-0733.
In enzymology, a purine-nucleoside phosphorylase (EC 2.4.2.1) is an enzyme that catalyzes the chemical reaction: purine nucleoside + phosphate <-> purine + alpha-D-ribose 1-phosphate. Thus, the two substrates of this enzyme are purine nucleoside and phosphate, whereas its two products are purine and alpha-D-ribose 1-phosphate. This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. Applications: This enzyme is useful for enzymatic determination of inorganic phosphorus, 5'-nucleotidase and adenosinedeaminase when coupled with xanthine oxidase and uricase. Group: Enzymes. Synonyms: EC 2.4.2.1; inosine phosphorylase; PNPase; PUNPI; PUNPII; inosine-guanosine phosphorylase; nucleotide phosphatase; purine deoxynuc. Enzyme Commission Number: EC 2.4.2.1. CAS No. 9030-21-1. PNPase. Mole weight: approx. 120 kDa. Activity: Grade? 15U/mg-solid or more. Stability: Stable at-20°C for at least 12 months. Appearance: White amorphous powder, lyophilized. Source: Microorganism. EC 2.4.2.1; inosine phosphorylase; PNPase; PUNPI; PUNPII; inosine-guanosine phosphorylase; nucleotide phosphatase; purine deoxynucleoside phosphorylase; purine deoxyribonucleoside phosphorylase; purine nucleoside phosphorylase; purine ribonucleoside phosphorylase; purine-nucleoside: phosphate ribosyltransferase. Cat No: DIA-216.
Native Microorganism Xanthine oxidase
Xanthine oxidase is a form of xanthine oxidoreductase, a type of enzyme that generates reactive oxygen species. These enzymes catalyze the oxidation of hypoxanthine to xanthine and can further catalyze the oxidation of xanthine to uric acid. These enzymes play an important role in the catabolism of purines in some species, including humans. Applications: This enzyme is useful for enzymatic determination of inorganic phosphorus, 5'-nucleotidase and adenosinedeaminase when coupled with purine-nucleoside phosphorylase and uricase. Group: Enzymes. Synonyms: EC 1.1.3.22; Xanthine oxidase; XO; XAO. Enzyme Commission Number: EC 1.1.3.22. CAS No. 9054-84-6. XAO. Mole weight: approx. 160 kDa. Activity: Grade? 10U/mg-solid or more. Stability: Stable at-20°C for at least year. Appearance: Reddish brown amorphous powder, lyophilized. Source: Microorganism. EC 1.1.3.22; Xanthine oxidase; XO; XAO. Cat No: DIA-218.
Nebularine (High Purity)
Nucleoside analog. Cytotoxic. DNA, RNA and protein synthesis inhibitor. Shows anticancer activity. Anti-mycobacterial. Has tuberculostatic activity. Antifungal activity. Antiviral (anti-Herpes). Adenosinedeaminase inhibitor. Can be used to analyze structure determinants of DNA that are recognized by DNA repair enzymes, to locate triple helices at G-C sequences or as an universal base, which can bind to all four of the nucleosides of DNA. Group: Biochemicals. Alternative Names: Purine-9-ß-D-ribofuranoside; 9- β-D-Ribofuranosyl-9H-purine; Ribosyl-isopurine; Purinosine; NSC 65423. Grades: Highly Purified. CAS No. 550-33-4. Pack Sizes: 500ug, 1mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences.
Worldwide
Pentostatin
An adenosinedeaminase inhibitor used as an anti-cancer therapeutic drug. Shown to be effective in the treatment of hairy cell leukemia as well as having use in the treatment of other types of cancer such as chronic lymphocytic leukemia. Group: Biochemicals. Alternative Names: (8R)-3-(2-deoxy- β-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydro-imidazo[4,5-d][1,3]diazepin-8-ol; (R)-; 2'-DCF; 2'-Deoxycoformycin; CI 825; CL 67310465; Cl 825; Co-V; Co-Vidarabine; Coforin; NSC 218321; NSC 247520; Nipent; PD-ADI; Vira A Deaminase Inhibitor. Grades: Highly Purified. CAS No. 53910-25-1. Pack Sizes: 1mg, 5mg, 10mg, 25mg. US Biological Life Sciences.
Worldwide
Pentostatin
Pentostatin (CI-825; Deoxycoformycin) is an irreversible inhibitor of adenosinedeaminase with K i of 2.5 pM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CI-825; Deoxycoformycin. CAS No. 53910-25-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-A0006.
Pentostatin
Pentostatin is an adenosinedeaminase inhibitor isolated from Streptomyces and effective against cancer cell lines. Pentostatin is a purine nucleoside analog that irreversibly inhibits adenosinedeaminase (Ki = 0.9 pM) and thus interrupts DNA synthesis in dividing cells. Pentostatin has been reported to display strong efficacy in the clinical treatment of hairy cell leukemia as well as relapsed chronic lymphocytic leukemia. Synonyms: 2'-deoxycoformycin; co-vidarabine; deoxycoformycin; covidarabine; deoxycoformycin; Nipent; (R)-3-(2-deoxy-beta-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol. Grades: >98%. CAS No. 53910-25-1. Molecular formula: C11H16N4O4. Mole weight: 268.27.
A potent inhibitor of phosphodiesterase II (PDE II) (IC50=800nM). Does ot inhibit other PDE isozymes (IC50>100uM). Inhibits the retrograde transport motor, dynein. Also inhibits adenosinedeaminase (Ki=4nM). Group: Biochemicals. Alternative Names: EHNA. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences.
Worldwide
(S)-9-[2-(Hydroxypropyl] Adenine
(S)-9-[2-(Hydroxypropyl] Adenine is an inhibitor of adenosinedeaminase. (S)-9-[2-(Hydroxypropyl] Adenine is used in the preparation of antiviral acyclic nucleoside thiophosphonates such as (S)-Tenofovir Disoproxil Fumarate (T018506). Group: Biochemicals. Alternative Names: (S)-9-(2-Hydroxypropyl)adenine; 9-[(2S)-2-Hydroxypropyl]adenine; L-(+)-9-(2-Hydroxypropyl)adenine; (αS)-6-Amino-α-methyl-9H-purine-9-ethanol. Grades: Highly Purified. CAS No. 14047-27-9. Pack Sizes: 250mg. US Biological Life Sciences.
Worldwide
SDZ WAG 994
SDZ WAG 994 is a potent and selective adenosine A1 receptor agonist (Ki = 23, > 10000 and 25000 nM for A1, A2A and A2B receptors, respectively). SDZ WAG 994 has been shown to lower blood pressure levels and heart rate in spontaneous hypertensive rats, and inhibit adenosinedeaminase-stimulated lipolysis in rat adipocytes (Ki = 8 nM). Synonyms: Adenosine, N-cyclohexyl-2'-O-methyl-; N-Cyclohexyl-2'-O-methyladenosine; SDZ-WAG 994; WAG 994. Grades: ≥99% by HPLC. CAS No. 130714-47-5. Molecular formula: C17H25N5O4. Mole weight: 363.41.
tRNA(adenine34) deaminase
The enzyme is involved in editing of tRNA. The active site contains Zn2+. Group: Enzymes. Synonyms: tRNA:A34 deaminase; tadA protein; ADAT2-ADAT3 complex; TADA; tRNA adenosinedeaminase arginine; AtTadA; tadA/ecADAT2; tRNA A:34 deaminase. Enzyme Commission Number: EC 3.5.4.33. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4561; tRNA(adenine34) deaminase; EC 3.5.4.33; tRNA:A34 deaminase; tadA protein; ADAT2-ADAT3 complex; TADA; tRNA adenosinedeaminase arginine; AtTadA; tadA/ecADAT2; tRNA A:34 deaminase. Cat No: EXWM-4561.
tRNAAla(adenine37) deaminase
The enzyme deaminates adenosine37 to inosine in eukaryotic tRNAAla. tRNA editing is strictly dependent on Mg2+. Group: Enzymes. Synonyms: ADAT1; Tad1p. Enzyme Commission Number: EC 3.5.4.34. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4562; tRNAAla(adenine37) deaminase; EC 3.5.4.34; ADAT1; Tad1p. Cat No: EXWM-4562.
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