Adenylate Cyclase Suppliers USA
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Product | Description | |
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PACAP-27, Amide, Sheep (Pituitary Adenylate Cyclase Activating Polypeptide, HSDGIFTDSYSRYRKQMAVKKy l AAVL-NH2) Quick inquiry Where to buy Suppliers range | Increases cAMP levels in a dose-dependent manner (EC50=4.7nM). Increases tyrosine hydroxylase expression in chromaffin cells.CAS No:127317-03-7. Group: Biochemicals. Grades: Highly Purified. CAS No. 127317-03-7. Pack Sizes: 0.5mg. Molecular Formula: C???H???N??O??S, Molecular Weight: 3147.7. US Biological Life Sciences. | Worldwide |
1,9-Dideoxyforskolin Quick inquiry Where to buy Suppliers range | 1,9-Dideoxyforkskolin does not activate adenylyl cyclase and is an inactive analog of Forskolin, a diterpene isolated from Coleus forskohlii, possessing vasodilating and cardiostimulatory properties. Forskolin resensitizes cell receptors by activating the enzyme adenylyl cyclase and increasing the intracellular levels of cAMP. Group: Biochemicals. Grades: Highly Purified. CAS No. 64657-18-7. Pack Sizes: 1mg, 5mg. Molecular Formula: C22H34O5, Molecular Weight: 378.5. US Biological Life Sciences. | Worldwide |
1-Deoxyforskolin Quick inquiry Where to buy Suppliers range | 1-Deoxyforskolin is active against HIVNL4-3. It also activates mammalian membranous adenylyl cyclase (AC) isoforms I-VIII. Group: Biochemicals. Grades: Highly Purified. CAS No. 72963-77-0. Pack Sizes: 500ug, 1mg. Molecular Formula: C22H34O6. US Biological Life Sciences. | Worldwide |
2',5'-Dideoxy adenosine Quick inquiry Where to buy Suppliers range | 2',5'-Dideoxy adenosine is a nucleoside analog that is one of the first identified cell-permeable, P-site inhibitors of adenylate cyclase. It inhibits forskolin-induced activation of a cAMP-dependent reporter gene in HEK293 cells with an IC50 value of 33 μM. Synonyms: 2?,5?-dd-Ado; (2R,3S,5R)-5-(6-aminopurin-9-yl)-2-methyloxolan-3-ol. Grades: ≥98%. CAS No. 6698-26-6. Molecular formula: C10H13N5O2. Mole weight: 235.2. | |
2'-?MeCCPA Quick inquiry Where to buy Suppliers range | 2'-?MeCCPA is an inhibitor of forskolin-stimulated adenylyl cyclase. It is also a selective A1 adenosine receptor agonist. Group: Biochemicals. Grades: Highly Purified. CAS No. 205171-12-6. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C16H22ClN5O4, Molecular Weight: 383.83. US Biological Life Sciences. | Worldwide |
2-MeS-5'-AMP Quick inquiry Where to buy Suppliers range | 2-MeS-5'-AMP is a potent antagonist of adenylate cyclase-coupled platelet ADP P2Y purinoceptor. Synonyms: 2- Methylthioadenosine- 5'- O- monophosphate, sodium salt. Grades: ≥ 97% by HPLC. CAS No. 22140-20-1. Molecular formula: C11H16N5O7PS (free acid). Mole weight: 393.3 (free acid). | |
2-Palmitoylglycerol Quick inquiry Where to buy Suppliers range | 2-Palmitoylglycerol is an endogenous fatty acid glycerol ester that enhances activity of 2-arachidonylglycerol. It is an endogenous agonist of the CB1 and CB2 cannabinoid receptors. 2-Palmitoylglycerol does not bind directly to cannabinoid receptors, nor inhibit adenylyl cyclase, but rather potentiates the activity of 2-AG (and other endocannabinoids) to bind to CB1 and CB2 and inhibit adenylyl cyclase. Synonyms: 2-Hydroxy-1-(hydroxymethyl)ethyl hexadecanoic acid ester; 2-Monohexadecanoylglycerol; 2-Monopalmitin; 2-Monopalmitoyl-sn-glycerol; 2-Monopalmitoylglycerol; 2-Palmitoylglycerol; Glycerol-β-palmitate; Palmitic Acid β-monoglyceride; β-Monopalmitin. CAS No. 23470-00-0. Molecular formula: C19H38O4. Mole weight: 330.51. | |
4-(Benzyloxy)benzaldehyde Quick inquiry Where to buy Suppliers range | Ibuprofen Related Compound is a position isomer of the adenylyl cyclase activator 2-Benzyloxybenzaldehyde. It also has much less potent anticancer activity against HL-60 cells that its isomeric counterpart. Synonyms: 4-phenylmethoxybenzaldehyde. Grades: > 95 %. CAS No. 4397-53-9. Molecular formula: C14H12O2. Mole weight: 212.24. | |
4-Thio-i-propyl-UTP Quick inquiry Where to buy Suppliers range | 4-Thio-i-propyl-UTP, a biochemical compound used in biomedical research, is known for its efficacy in the evaluation of P2Y receptor function. Scientists heavily rely on it to look at signaling pathways implicated in diseases affecting multiple organ systems such as cancer, diabetes, and neurodegenerative disorders. This substrate has the power to activate adenylate cyclase through P2Y receptor-mediated processes. Studying these receptors using this compound has been shown to shed light on pathogenic mechanisms. Its use is well-established across the scientific community, both in vitro and in vivo. Synonyms: 4-Thio-iso-propyl-uridine-5'-triphosphate, Sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C12H21N2O14P3S (free acid). Mole weight: 542.27 (free acid). | |
5-Nonyloxytryptamine oxalate Quick inquiry Where to buy Suppliers range | 5-Nonyloxytryptamine oxalate is a potent agonist of the serotonin (5-HT) receptor 5-HT1Dβ with an EC50 value of 68 nM for adenylate cyclase activity in CHOKM6 cells transfected with the human 5-HT1Dβ receptor. It is several times more potent than sumatriptan and inactive as a 5-HT1A agonist (Ki at 5-HT1B = 1 nM, selectivity over 5-HT1A > 300-fold). Synonyms: 5-(Nonyloxy)-1H-Indole-3-ethanamine ethanedioate; 5-(Nonyloxy)tryptamine oxalate; 5-Nonyloxytryptamine oxalate. Grades: ≥99% by HPLC. CAS No. 157798-13-5. Molecular formula: C19H30N2O.C2H2O4. Mole weight: 392.49. | |
6-Chloro-5-(2,3-dichlorophenoxy)-2-methylthio-benzimidazole (Triclabendazole) Quick inquiry Where to buy Suppliers range | Triclabendazole is a member of the benzimidazole family of anthelmintics. It is effective against F. hepatica helminths that cause fascioliasis, reducing secreted protease enzyme activities that are critical for the invasion, migration, nutrition, and survival of the parasite.1 In yeast and mammalian cells, triclabendazole was shown to inhibit adenylyl cyclase in the Ras-adenylyl cyclase-protein kinase A nutrient-sensing pathway and to prevent apoptosis induced by the Parkinsons disease-related protein α-synuclein, demonstrating a protective role during various cellular stresses.2,3. Group: Biochemicals. Alternative Names: 5-Chloro-6- (2, 3-dichlorophenoxy) -2- methyl thiobenzimidazole; CGA-89317, egaten; Fasinex; Triclabendazole. Grades: Highly Purified. CAS No. 68786-66-3. Pack Sizes: 25g, 50g, 100g. Molecular Formula: C14H9Cl3N2OS, Molecular Weight: 359.66. US Biological Life Sciences. | Worldwide |
6-Chloropurine Riboside 5'-Triphosphate Triethylamine Salt Quick inquiry Where to buy Suppliers range | 6-Chloropurine Riboside 5'-Triphosphate Triethylamine Salt is a structural analog of Adenosine Triphosphate (ATP) and can irreversibly inhibit adenylate cyclase from rat brains. Synonyms: 6-Chloro-9-[5-O-[hydroxy[[hydroxy (phosphonooxy) phosphinyl]oxy]phosphinyl]-β -D-ribofuranosyl]-9H-purine Triethylamine Salt. Molecular formula: C10H14ClN4O13P3(free acid). Mole weight: 526.61. | |
8-[(6-Amino)hexyl]-amino-adenosine-2',5'-bisphosphate - Cy3 Quick inquiry Where to buy Suppliers range | 8-[(6-Amino)hexyl]-amino-adenosine-2',5'-bisphosphate - Cy3 is a fluorescently labeled nucleotide analog that is utilized for the purpose of monitoring adenylate cyclase activity and intracellular signaling pathways. This unique compound boasts a wide range of applications, such as studying the activation of the Gs protein-coupled receptor, which then activates its downstream effectors PKA and CREB. Not only is this product useful in understanding these critical signaling pathways, but also in drug development procedures that aim to target GPCR signaling pathways. Synonyms: 8-[(6-Amino)hexyl]-amino-adenosine-2',5'-bisphosphate, labeled with Cy3, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C47H65N9O17P2S2 (free acid). Mole weight: 1154.15 (free acid). | |
8-[(6-Amino)hexyl]-amino-adenosine-2',5'-bisphosphate - DY-480XL Quick inquiry Where to buy Suppliers range | DY-480XL, a biomedicine product specialized in biochemical studies, offers an intricate solution to understanding the dynamics of enzymatic interactions and signaling pathways. As a fluorescent analog of 2',5'-ADP, this product boasts the capability to study complex enzyme activities such as adenylate cyclase and cyclic nucleotide phosphodiesterase. Furthermore, it can delve into the intricate signaling pathways activated by extracellular receptors, which induce G protein-coupled pathways. The product's versatility renders it invaluable in the oncology research sphere, with its potential applications ranging from breast, ovarian to colon cancer. Synonyms: 8-[(6-Amino)hexyl]-amino-adenosine-2',5'-bisphosphate, labeled with DY 480XL, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C42H57N9O16P2S (free acid). Mole weight: 1037.97 (free acid). | |
8-[(6-Amino)hexyl]-amino-adenosine-3',5'-bisphosphate - 6-FAM Quick inquiry Where to buy Suppliers range | 8-[(6-Amino)hexyl]-amino-adenosine-3',5'-bisphosphate - 6-FAM is a fluorescently-labeled derivative of adenosine-3',5'-bisphosphate, a signaling molecule and second messenger within cells. This product is used in biomedical research to study the regulation of intracellular signaling pathways involving adenylate cyclase and phosphodiesterases. It can also be used to investigate nucleotide metabolism and the role of adenylyl cyclases in diseases such as cardiac and neurological disorders. Synonyms: 8-[(6-Amino)hexyl]-amino-adenosine-3',5'-bisphosphate, labeled with 6 FAM, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C37H39N7O16P2 (free acid). Mole weight: 899.70 (free acid). | |
8-[(6-Amino)hexyl]-amino-cAMP - 6-JOE Quick inquiry Where to buy Suppliers range | 8-[(6-Amino)hexyl]-amino-cAMP - 6-JOE, a fluorescent analog of cyclic AMP, presents immense academic value as a research tool for investigating cellular signaling pathways through adenylyl cyclase and phosphodiesterase activity, as well as cAMP receptor binding. Its diverse potential applications to the regulation of cellular signaling in diseases such as diabetes and heart disease, underscores its profound scientific relevance. Synonyms: 8-[(6-Amino)hexyl]-amino-adenosine-3',5'-cyclic monophosphate, labeled with 6-JOE, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C39H38Cl2N7O14P (free acid). Mole weight: 929.16 (free acid). | |
8-[(6-Amino)hexyl]-amino-cAMP - ATTO-495 Quick inquiry Where to buy Suppliers range | 8-[(6-Amino)hexyl]-amino-cAMP - ATTO-495, a fluorescent probe with highly-specific binding properties to the regulatory subunit of PKA, is a powerful tool that can monitor the activity of adenylate cyclase in living cells. Its utility extends beyond just studying PKA activity, as it can also aid in the identification of targets for cancer treatment by investigating the role of cAMP in cancer cells. With its vast array of research applications, this product is a must-have for any serious researcher. Synonyms: 8-[(6-Amino)hexyl]-amino-adenosine-3',5'-cyclic monophosphate, labeled with ATTO 495, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C37H49N10O7P (free acid). Mole weight: 776.82 (free acid). | |
8-[(6-Amino)hexyl]-amino-cAMP - DY-751 Quick inquiry Where to buy Suppliers range | 8-[(6-Amino)hexyl]-amino-cAMP - DY-751 is an intricate and sophisticated synthetic compound, serving as an exceptional and exclusive cyclic adenosine monophosphate (cAMP) analogue that possesses a structurally modified framework. Demonstrating remarkable potency, DY-751 acting as an efficacious agonist, displaying selectivity towards specific subcategories of adenylyl cyclase. Synonyms: 8-[(6-Amino)hexyl]-amino-adenosine-3',5'-cyclic monophosphate, labeled with DY 751, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C58H76N9O14PS2 (free acid). Mole weight: 1217.47 (free acid). | |
8-Bromo-AMP Quick inquiry Where to buy Suppliers range | 8-Bromo-AMP, a pharmaceutical compound widely employed in the biomedical sector, holds significant importance in the exploration and management of diverse diseases. As a derivative of adenosine monophosphate (AMP), it possesses altered characteristics that play a pivotal role in cellular metabolism and signaling. Moreover, owing to its utilization in signal transduction pathway investigations and assessment of adenylyl cyclase activation effects, 8-Bromo-AMP showcases its versatility. Synonyms: (8Br-AMP); 8-Bromo-adenosine-5'-monophosphate, Sodium salt. Grades: ≥ 95% by HPLC. CAS No. 23567-96-6. Molecular formula: C10H13BrN5O7P (free acid). Mole weight: 426.12 (free acid). | |
8-Bromo-AppNHp Quick inquiry Where to buy Suppliers range | 8-Bromo-AppNHp, a coveted biochemical compound, brimming with potential, is considered an integral tool in the unprecedented scientific endeavors to unravel the mysteries of signal transduction and protein activation pathways. Its significance lies in its extraordinary ability to emulate adenosine triphosphate (ATP), lending an unfiltered glimpse into the functional intricacies of G-proteins and adenylate cyclases. Its presence has revolutionized the world of medicinal research, opening new horizons in the quest to tackle both neurological disorders and cardiovascular diseases. Synonyms: (8Br-AppNHp, 8Br-AMPPNP); 8-Bromo-adenosine-5'-[(β,γ)-imido]triphosphate, Sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C10H16N6O12P3Br (free acid). Mole weight: 585.09 (free acid). | |
Acetyl PACAP (1-38) (human, mouse, ovine, porcine, rat) trifluoroacetate salt Quick inquiry Where to buy Suppliers range | Acetyl pituitary adenylate cyclase-activating peptide (PACAP) (1-38) is an N-terminally acetylated form of PACAP (1-38). Synonyms: Acetyl pituitary adenylate cyclase-activating peptide (1-38). Grades: ≥95%. Molecular formula: C205H333N63O54S·xCF3COOH. Mole weight: 4576.29. | |
Adenosine 3',5'-diphosphate disodium salt Quick inquiry Where to buy Suppliers range | Adenosine 3',5'-diphosphate disodium salt, a ligand of adenylate cyclase and regulator of AMP-dependent protein kinase, plays a crucial role in energy metabolism and serves as a substrate for CD73. It possesses unique abilities in regulating inflammatory responses in the immune system and battling cardiovascular diseases like myocardial infarction and angina, making it a highly prized compound in the biomedical industry. Synonyms: 3'-Phosphoadenosine 5'-phosphate; PAP; Adenosine 3',5'-bisphosphate sodium salt. Grades: 96%. CAS No. 75431-54-8. Molecular formula: C10H15N5O10P2·2Na. Mole weight: 473.18. | |
Adenosine 5 Triphosphate Disodium, Trihydrate (5'-ATP·2Na·3H2O) Quick inquiry Where to buy Suppliers range | Adenosine 5?-triphosphate (ATP) is a central component of energy storage and metabolism in vivo. ATP is use in many cellular processes, respiration, biosynthetic reactions, motility, and cell division. ATP is a substrate of many kinases involved in cell signaling and of adenylate cyclase(s) that produce the second messenger cAMP. ATP provides the metabolic energy to drive metabolic pumps. ATP serves as a coenzyme in a wide array of enzymatic reactions. Group: Biochemicals. Alternative Names: ATP 2Na; ATP disodium salt. Grades: Molecular Biology Grade. CAS No. 51963-61-2. Pack Sizes: 5g, 25g, 100g, 500g. Molecular Formula: C10H14N5O13P3Na2 3H2O, Molecular Weight: 605.19. US Biological Life Sciences. | Worldwide |
Adenosine 5?-Triphosphate Magnesium Salt (ATP) Quick inquiry Where to buy Suppliers range | Adenosine 5y-triphosphate (ATP) is a central component of energy storage and metabolism in vivo. ATP is use in many cellular processes, respiration, biosynthetic reactions, motility, and cell division. ATP is a substrate of many kinases involved in cell signaling and of adenylate cyclase(s) that produce the second messenger cAMP. ATP provides the metabolic energy to drive metabolic pumps. ATP serves as a coenzyme in a wide array of enzymatic reactions. Group: Biochemicals. Alternative Names: ATP magnesium salt. Grades: Highly Purified. CAS No. 74804-12-9. Pack Sizes: 100mg, 500mg, 1g. Molecular Formula: C10H16N5O13P3·xMg2+, Molecular Weight: 529.47. US Biological Life Sciences. | Worldwide |
Adenosine A1 Receptor Agonist II, CCPA ( (2R, 3R, 4S, 5R) -2- (2-chloro-6- (cyclopentylamino) -9H-purin-9-yl) -5- (hydroxymethyl) tetrahydrofuran-3, 4-diol, 2-Chloro-N6-cyclopentyladenosine) Quick inquiry Where to buy Suppliers range | An adenosine analog that acts as a selective, high affinity agonist for Adenosine A1 receptor (A1R) (Ki = 800 pM; 2.3uM, 18.8uM, and 42nM for human A1, A2A, A2B, A3 respectively). Shown to be centrally active following systemic administration and exhibits anti-convulsive effects. Also reported to inhibit adenylate cyclase activity in rat fat cell membrane (IC50 = 33nM). Diminishes respiratory rhythm, reduces heart rate, and enhances the activity of KATP channels. Reduces norepinephrine release by about 50% in untreated and pertussis toxin treated hearts.CAS Number:37739-05-2. Group: Biochemicals. Grades: Highly Purified. CAS No. 37739-05-2. Pack Sizes: 10mg. Molecular Formula: C??H??ClN?O?. US Biological Life Sciences. | Worldwide |
Adenosine A1 Receptor Antagonist I, DPCPX (8-Cyclopentyl-1,3-dipropylxanthine, CPX, PD-116,948) Quick inquiry Where to buy Suppliers range | A blood-brain barrier permeable xanthine derivative that acts as a highly selective antagonist of Adenosine A1 receptor (A1R; Ki = 3.9nM, 130nM, 1.0uM, 4.0uM for human A1, A2A, A2B, and A3 respectively). Exhibits about 1,000-fold higher affinity and a 30-fold greater selectivity for A1R when compared to theophylline. Shown to competitively antagonize the inhibition of adenylate cyclase activity via A1 adenosine receptors in rat fat cells and the stimulation of adenylate cyclase via A2 adenosine receptors in human platelets. Exhibits hypertensive properties. Group: Biochemicals. Grades: Highly Purified. CAS No. 102146-07-6. Pack Sizes: 25mg. Molecular Formula: C??H??N?O?, Primary Target: A1. US Biological Life Sciences. | Worldwide |
Adenylyl-3'-5'-cytidine Quick inquiry Where to buy Suppliers range | Adenylyl-3'-5'-cytidine is a highly effective and specialized adenylyl cyclase activator, holding applications in biomedical research for investigating the cyclic adenosine monophosphate (cAMP) signaling pathways. Uses: Enzyme inhibitors. Synonyms: Adenylyl-3'-5'-D-cytidine. Grades: 98%. CAS No. 2382-66-3. Molecular formula: C19H25N8O11P. Mole weight: 572.42. | |
Adenylyl-3'-5'-uridine ammonium salt Quick inquiry Where to buy Suppliers range | Adenylyl-3'-5'-uridine ammonium salt is a versatile biochemical reagent utilized in several applications, including substrates for adenylyl cyclase, and researching cyclic nucleotide signaling. Its potential as a therapeutic agent is apparent in its integral role within the development of antiviral drugs against Hepatitis C Virus (HCV) infection. Molecular formula: C19H24N7O12P. Mole weight: 573.41. | |
(Ala11.22.28)-VIP (human, mouse, rat) Quick inquiry Where to buy Suppliers range | (Ala11.22.28)-VIP (human, mouse, rat), a highly selective human VPAC1 receptor agonist, shows a 1000-fold higher efficiency in stimulating adenylate cyclase activity from VPAC1 than VPAC2 receptors. It is a valid pharmacological tool for characterizing VPAC1 receptor-mediated events. Synonyms: (Ala11.22.28)-Aviptadil; H-His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Ala-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Ala-Leu-Asn-Ser-Ile-Leu-Ala-NH2; L-histidyl-L-seryl-L-alpha-aspartyl-L-alanyl-L-valyl-L-phenylalanyl-L-threonyl-L-alpha-aspartyl-L-asparagyl-L-tyrosyl-L-alanyl-L-arginyl-L-leucyl-L-arginyl-L-lysyl-L-glutaminyl-L-methionyl-L-alanyl-L-valyl-L-lysyl-L-lysyl-L-alanyl-L-leucyl-L-asparagyl-L-seryl-L-isoleucyl-L-leucyl-L-alaninamide. Grades: ≥95% by HPLC. CAS No. 291524-04-4. Molecular formula: C139H231N43O39S. Mole weight: 3160.65. | |
α-Melanocyte-Stimulating Hormone (MSH), amide Quick inquiry Where to buy Suppliers range | α-Melanocyte-Stimulating Hormone (MSH), is an endogenous melanocortin receptor agonist that results in the activation of adenylyl cyclase, with anti-inflammatory effect. Synonyms: CZEN-002; CZEN002; CZEN 002; α-MSH; α-MSH, amide; α-Melanotropin; α-Melanocyte stimulating hormone. Grades: 98%. CAS No. 581-05-5. Molecular formula: C77H109N21O19S. Mole weight: 1637.88. | |
α-Melanocyte-Stimulating Hormone (MSH), amide Quick inquiry Where to buy Suppliers range | α-Melanocyte-Stimulating Hormone (MSH), amide stimulates melanocortin 1 receptor that results in the activation of adenylyl cyclase. Uses: Peptide Inhibitors. CAS No. 581-05-5. Product ID: R1763. | |
BMS 986122 Quick inquiry Where to buy Suppliers range | BMS 986122 is a positive allosteric modulator of the μ-Opioid receptor. It significantly increases the inhibition of forskolin-stimulated adenylyl cyclase activity produced by an EC10 (30 pM) concentration of endomorphin-I in CHO-μ cells. BMS 986122 potentiates endomorphin 1-induced inhibition of forskolin-stimulated adenylyl cyclase activity in CHO cells expressing human recombinant μ-opioid receptors with EC50 of 8.9 μM. It also enhances [35S]GTPγ binding stimulated by the μ-opioid agonist DAMGO by 7- and 4.5-fold in C6μ glioma cell membranes. Synonyms: BMS-986122; BMS986122; 2-(3-bromo-4-methoxyphenyl)-3-[(4-chlorophenyl)sulfonyl]-thiazolidine. Grades: ≥98%. CAS No. 313669-88-4. Molecular formula: C16H15BrClNO3S2. Mole weight: 448.8. | |
Bmy 42393 Quick inquiry Where to buy Suppliers range | BMY-42393 is a selective platelet aggregation inhibitor. It is also a prostacyclin partial agonist that inhibited ADP, collagen and thrombin-induced platelet aggregation with IC50 value range from 0.3 to 2.0 mM. BMY-42393 can stimulate platelet adenylate cyclase with EC50 value of 25 nM. BMY 42393 can also inhibit thrombin-induced elevation of intracellular free calcium. Research for the treatment of Hyperlipidaemia was discontinued. Uses: Hyperlipidaemia. Synonyms: BMY-42393; BMY 42393; BMY42393. SCHEMBL675089; AC1L304B; CHEMBL117835;2-[3-[2-(4,5-diphenyl-1,3-oxazol-2-yl)ethyl]phenoxy]acetic acid. Grades: 98%. CAS No. 136451-58-6. Molecular formula: C25H21NO4. Mole weight: 399.45. | |
BPIPP Quick inquiry Where to buy Suppliers range | BPIPP is a non-competitive guanylyl cyclase (GC) and adenylyl cyclase (AC) inhibitor. It downregulates cAMP and cGMP synthesis, suppresses cGMP accumulation in a variety of cell lines (IC50 = 3.4 - 11.2 μM), inhibits GC-stimulated Cl- transport in vitro, and suppresses toxin-induced intestinal fluid accumulation in vivo. BPIPP may be a useful treatment of diarrhea. Uses: Potential treatment of diarrhea. Synonyms: 5-(3-Bromophenyl)-5,11-dihydro-1,3-dimethyl-1H-indeno[2',1':5,6]pyrido[2,3-d]pyrimidine-2,4,6(3H)-trione. Grades: ≥99% by HPLC. CAS No. 325746-94-9. Molecular formula: C22H16BrN3O3. Mole weight: 450.28. | |
BW A868C Quick inquiry Where to buy Suppliers range | Prostaglandin D2 (PGD2) has been widely distributed in rat brain, spinal cord and pituitary and may act as a neuromodulator in the central nervous system. BW A868C is a novel, selective and potent competitive antagonist of PGD2. BW A868C antagonizes the prostaglandin D2 and BW 245C-induced activation of human platelet adenylate cyclase. BW A868C antagonizes the accumulation of cAMP in rabbit non-pigmented ciliary epithelial cells. However, it has virtually no effect on human TP, IP, EP1, EP2, and FP receptors. Synonyms: BWA-868C; BWA868C. Grades: ≥98%. CAS No. 118675-50-6. Molecular formula: C25H37N3O5. Mole weight: 459.6. | |
cAMP (Cyclic Adenosine Monophosphate, Cyclic AMP, Adenosine 3'5'-cyclic Monophosphate) (HRP) Quick inquiry Where to buy Suppliers range | Cyclic Adenosine Monophosphate is a hydrophilic secondary messenger that is part of the cellular signal transduction pathway. It is produced by enzymatic methods on the molecule ATP by the enzyme adenylyl cyclase. It interacts with receptor proteins on the surface of a cell membrane following an intracellular signal produced by hormones or neurotransmitters. Cyclic AMP activates Protein Kinase A (PKA) catalytic ability. This activated PKA molecule transfers phosphate from ATP to different amino acid sequences. These phosphorylated amino acids can regulate calcium ion channels allowing calcium to move across the cellular membrane. Group: Biochemicals. Grades: Purified. Pack Sizes: 500ul. US Biological Life Sciences. | Worldwide |
CAY10449 Quick inquiry Where to buy Suppliers range | CAY10449 is one of compounds which are found to be high-affinity ligands and functional antagonists for the human IP (prostacyclin) receptor. It antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase. It also inhibits the binding of tritiated iloprost to rodent neuroblastoma cells with a Ki of about 3 nM. Synonyms: CAY 10449; CAY-10449. Grades: ≥98%. Molecular formula: C19H21N3O2. Mole weight: 323.4. | |
CB-7921220 Quick inquiry Where to buy Suppliers range | CB-7921220 is an adenylate cyclase inhibitor which is selective, reducing adenylyl cyclase type I and VI activity by 60% while having no effect on types II and V in Sf9 membranes stimulated by forskolin at a concentration of 100 μM. CB-7921220 has a binding conformation similar to ATP and P-site inhibitors, which may explain its lack of selectivity between AC1 and AC6. Synonyms: CB7921220; CB 7921220; CB-7921220; 6-[(E)-2-(4-aminophenyl)ethenyl]pyridine-2-carboxylic acid. CAS No. 115453-99-1. Molecular formula: C14H12N2O2. Mole weight: 240.26. | |
CGP 35348 (GABAB Receptor Antagonist, CGP 35348, CGP35348, CGP-35348) Quick inquiry Where to buy Suppliers range | A selective antagonist of post-synaptic GABAB receptors (IC50 = 34uM) that can permeate the blood brain barrier. Exhibits about 10-fold lower affinity for pre-synaptic receptors. Blocks K+-evoked glycine exocytosis in mouse spinal cord and hippocampal nerve endings. Shown to antagonize the potentiating effect of L-baclofen on noradrenaline-induced stimulation of adenylate cyclase in rat cortex slices. Group: Biochemicals. Grades: Highly Purified. CAS No. 123690-79-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Cl-ANT-ITP Quick inquiry Where to buy Suppliers range | Cl-ANT-ITP is an analogue of inosine-5'-triphosphate and an inhibitor of mammalian adenylate cyclases, of which the intrinsic fluorescence would increase in hydrophobic environment. Synonyms: 2'- / 3'- O- (5- Chloroanthraniloyl)inosine- 5'- O- triphosphate, sodium salt. Grades: ≥ 95% by HPLC. CAS No. 1350521-48-0. Molecular formula: C17H19ClN5O15P3 (free acid). Mole weight: 661.7 (free acid). | |
CP-154526 Hydrochloride Quick inquiry Where to buy Suppliers range | A selective, non-peptide antagonist of corticotropin releasing factor receptors (CRF1). It blocks CRF-induced adenylate cyclase activation and attenuates activation of the HPA axis by CRF. It displayed anxiolytic-like activity in the rat elevated plus-maze test; brain penetrant. Group: Biochemicals. Alternative Names: N-Butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Hydrochloride. Grades: Highly Purified. CAS No. 257639-98-8. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
[D-Ala2, N-Me-Phe4, Gly5-ol]-Enkephalin acetate salt Quick inquiry Where to buy Suppliers range | DAMGO is an analog of μ-Receptor-specific enkephalin. It stimulates calcium-activated adenylyl cyclases related cAMP production. Synonyms: DAMGO acetate; DAGO acetate; Tyr-D-Ala-Gly-N-Methyl-Phe-Gly-ol; L-Tyrosyl-D-alanylglycyl-N-(2-hydroxyethyl)-Nalpha-methyl-L-phenylalaninamide monoacetate (salt); L-Tyrosyl-D-alanylglycyl-N-(2-hydroxyethyl)-N-alpha-methyl-L-phenylalaninamide monoacetate (salt). Grades: 95%. CAS No. 100929-53-1. Molecular formula: C28H39N5O8. Mole weight: 573.64. | |
Deoxyandrographolide Quick inquiry Where to buy Suppliers range | Deoxyandrographolide is a natural compound extracted from the herbs of Andrographis paniculata (Burm. f.) Nees. It could potently inhibit the growth of liver (HepG2 and SK-Hep1) and bile duct (HuCCA-1 and RMCCA-1) cancer cells. It controlled ethanol-induced hepatosteatosis by interfering with dysregulation of lipid metabolism. It was capable of preventing the development of fatty liver through AMPK-mediated regulation of lipid metabolism. It reduced the extracellular acidification rate and the intracellular alkalinization in a dose-dependent manner in concentrations between 10-100 microM. It reduced PAF-induced calcium flux in the presence of extracellular calcium. It mediated activation of adenylate cyclase-cAMP signaling leading to up-regulation of cNOS may provide a promising approach in the prevention of liver diseases during chronic alcoholism. Uses: Deoxyandrographolide could potently inhibit the growth of liver (hepg2 and sk-hep1) and bile duct (hucca-1 and rmcca-1) cancer cells. it controlled ethanol-induced hepatosteatosis by interfering with dysregulation of lipid metabolism. it reduced the extracellular acidification rate and the intracellular alkalinization in a dose-dependent manner in concentrations between 10-100 microm. it reduced paf-induced calcium flux in the presence of extracellular calcium. Synonyms: 4-[2-[(4aS,5R,6R,8aR)-6-hydroxy-5-(hydroxymethyl)-2,5,8a-trimethyl-3,4,4a,6,7,8-hexahydronaphthalen-1-yl]ethyl]-2H-furan-5-one;2(5H)-Furanone, 3-[2-[(4aS,5R,6R,8aR)-3,4,4a,5,6,7,8,8a-octahydro-6-hydroxy-5-(hydroxymethyl)-2,5,8a-trimethyl-1-naphthalenyl]ethyl]-. Grades: >98%. CAS No. 79233-15-1. Molecular formula: C20H30O4. Mole weight: 334.45. | |
des-His1-[Glu9]-Glucagon (1-29) amide Quick inquiry Where to buy Suppliers range | A glucagon receptor antagonist (pA2 = 7.2 for inhibition of glucagon-induced adenylyl cyclase activation in rat liver membranes) that displays no agonist activity. It binds to glucagon receptors to stimulate breakdown of inositol phospholipids by phospholipase C. It was shown to potentiate glucose-stimulated pancreatic insulin release in vitro. It blocks added glucagon-induced hyperglycemia in normal rabbits without affecting glycogenolysis in vivo. Also blocks endogenous glucagon-induced hyperglycemia in streptozocin diabetic rats. Synonyms: (Des-His1,Glu9)-Glucagon (1-29) amide (human, rat, porcine); H-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Glu-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-NH2; L-seryl-L-glutaminyl-glycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-glutamyl-L-tyrosyl-L-seryl-L-lysyl-L-tyrosyl-L-leucyl-L-alpha-aspartyl-L-seryl-L-arginyl-L-arginyl-L-alanyl-L-glutaminyl-L-alpha-aspartyl-L-phenylalanyl-L-valyl-L-glutaminyl-L-tryptophyl-L-leucyl-L-methionyl-L-asparagyl-L-threoninamide. Grades: ≥95%. CAS No. 110084-95-2. Molecular formula: C148H221N41O47S. Mole weight: 3358.68. | |
[Des-His1,Glu9]-Glucagon (1-29) amide trifluoroacetate salt Quick inquiry Where to buy Suppliers range | [Des-His1,Glu9]-Glucagon (1-29) amide is a peptide glucagon receptor antagonist (pA2 = 7.25 for glucagon binding to isolated rat liver membranes). It binds to glucagon receptors in a magnesium- and GTP-independent manner to stimulate breakdown of inositol phospholipids by phospholipase C, but has no effect on adenylate cyclase activity, in hepatocytes. In vivo, [Des-His1,Glu9]-glucagon (1-29) amide prevents glucagon-induced hyperglycemia in rabbits and decreases blood glucose in rats with diabetes induced by streptozotocin. Grades: ≥95%. Molecular formula: C148H221N41O47S·xCF3COOH. Mole weight: 3358.65. | |
EDA-ADP - 6-ROX Quick inquiry Where to buy Suppliers range | EDA-ADP - 6-ROX, a fluorescent probe highly utilized in biochemical assays to monitor adenylate cyclase activity, features prominence in the cyclic AMP-dependent signal transduction pathway analysis for diseases such as diabetes, obesity, and cancer, making it an indispensable element in the evaluation of drug efficacy regarding this particular pathway. Synonyms: 2'/3'-O-(2-Aminoethyl-carbamoyl)-Adenosine-5'-diphosphate, labeled with 6-ROX, Triethylammonium salt. Grades: ≥ 95 % by HPLC. Molecular formula: C46H49N9O15P2(free acid). Mole weight: 1029.89 (free acid). | |
EDA-ATP - ATTO-Rho6G Quick inquiry Where to buy Suppliers range | EDA-ATP - ATTO-Rho6G, a fluorescent nucleotide analog, finds its utility in tracking activities pertinent to adenylate cyclase and other ATP-dependent processes in the realm of biochemical and cellular research. Additionally, the product is remarkable in its ability to serve as a label for imaging actin cytoskeleton dynamics, detecting intrusion into intracellular calcium concentration. Unquestionably, EDA-ATP - ATTO-Rho6G is an asset to the researcher's inventory in the rapidly evolving field of life sciences. Synonyms: 2'/3'-O-(2-Aminoethyl-carbamoyl)-Adenosine-5'-triphosphate, labeled with ATTO Rho6G, Triethylammonium salt. Grades: ≥ 95 % by HPLC. Molecular formula: C44H55N10O17P3(free acid). Mole weight: 1088.30 (free acid). | |
EMDT oxalate Quick inquiry Where to buy Suppliers range | EMDT oxalate is a selective 5-HT6 agonist (Ki = 16 nM at human 5-HT6 receptors) with antidepressant-like activity. It shows potency comparable to serotonin for the activation of adenylate cyclase. Synonyms: J-016404; J 016404; J016404; 2-Ethyl-5-methoxy-N,N-dimethyl-1H-indole-3-ethanamine oxalate. Grades: ≥98% by HPLC. CAS No. 263744-72-5. Molecular formula: C15H22N2O.C2H2O4. Mole weight: 336.38. | |
Epoprostenol Sodium Quick inquiry Where to buy Suppliers range | Epoprostenol Sodium is the sodium salt form of epoprostenol, which is a synthetic prostacyclin. It has vasodilatory and anticoagulant activity. It is a short-lived product of the cyclooxygenase pathway in vascular endothelial cells. It prevents the formation of platelet plugs and is an effective vasodilator. It is a potent inhibitor of platelet aggregation by antagonizing thromboxane A2 and stimulating platelet adenylyl cyclase. It directly simulates prostaglandin receptors in arterial vascular smooth muscle, thereby causing vasodilatation. lt is also used for the treatment of pulmonary hypertension. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. It is vasoprotective, protecting arterial walls from injury-induced lesions and cytoprotective in the liver and gastrointestinal tract. It was developed by GlaxoSmithKline and has been listed. Uses: Epoprostenol sodium has vasodilatory and anticoagulant activity. it prevents the formation of platelet plugs and is an effective vasodilator. lt is also used for the treatment of pulmonary hypertension. Synonyms: Prostacyclin Sodium Salt; (5Z,9α,11α,13E,15S)-6,9-epoxy-11,15-Dihydroxy-prosta-5,13-dien-1-oic Acid Sodium Salt; Flolan. Grades: >99 %. CAS No. 61849-14-7. Molecular formula: C20H31O5Na. Mole weight: 374.45. | |
Forskolin Quick inquiry Where to buy Suppliers range | Forskolin is a diterpene isolated from Coleus forskohlii, possessing vasodilating and cardiostimulatory properties. Forskolin resensitizes cell receptors by activating the enzyme adenylyl cyclase and increasing the intracellular levels of cAMP. Group: Biochemicals. Alternative Names: (3R, 4aR, 5S, 6S, 6aS, 10S, 10aR, 10bS)-5-(Acetyloxy)-3-ethenyldodecahydro-6, 10, 10b-trihydroxy-3, 4a, 7, 7, 10a-pentamethyl-1H-Naphtho[2, 1-b]pyran-1-one; (-)-Forskolin; Coleonol; Colforsin; ForsLean; HL 362; L 75-1362B; NSC 357088. Grades: Highly Purified. CAS No. 66575-29-9. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
Forskolin (7b-Acetoxy-8,13-epoxy-1a,6b,9a-trihydroxy- labd-14-ene-11-one, Coleonol, Colforsin) Quick inquiry Where to buy Suppliers range | Forskolin is a naturally occurring diterpene from the Indian plant, Coleus forskohlii, that works as an activator of adenylate cyclase resulting in an increase in the intracellular concentration of cAMP. Group: Biochemicals. Grades: Highly Purified. CAS No. 66575-29-9. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
Forskolin (7b-Acetoxy-8,13-epoxy-1a,6b,9a-trihydroxy- labd-14-ene-11-one, Colforsin) Quick inquiry Where to buy Suppliers range | Forskolin is a powerful activator of adenyklate cyclase, resulting in an increase of intracellular cAMP concentration.1,2 Activates adenylate cyclase leading to an increase in the intracellular concentration of cAMP. Widely used tool for the investigation of the role of cAMP as a second messenger with a broad range of potential therapeutic applications. Inotropic agent and vasodilator. Induces platelet aggregation. Inhibits ion channels by a mechanism that does not involve cAMP. Non-competitive inhibitor of nicotinic acetylcholine receptors. Group: Biochemicals. Grades: Highly Purified. CAS No. 66575-29-9. Pack Sizes: 10mg, 25mg, 100mg. US Biological Life Sciences. | Worldwide |
Forskolin (7b-Acetoxy-8,13-epoxy-1a,6b,9a-trihydroxy-labd-14-ene-11-one, Colforsin) Quick inquiry Where to buy Suppliers range | Activates adenylate cyclase leading to an increase in the intracellular concentration of cAMP. Group: Biochemicals. Grades: Highly Purified. CAS No. 66575-29-9. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
Forskolin (Boforsin, Colforsin, Coleonol, NSC 357088, NSC 375489) Quick inquiry Where to buy Suppliers range | Potent, cell permeable adenylyl cyclase activator. Increases intracellular cAMP levels. Widely used tool to investigate cAMP as a second messenger. Inotropic and antihypertensive. Smooth muscle relaxant/vasodilator. Glucose transporter inhibitor. Platelet aggregation inhibitor. Stimulates lipolysis in fat cells. Non-competitive nicotinic acetylcholine receptors inhibitor. MAP kinase inhibitor. Upregulates mitochondrial uncoupling protein (UCP) mRNA levels in brown adipose tissue. Autophagy inhibitor. Hedgehog signaling inhibitor. Has antiglaucoma potential. Promotes neuronal differentiation of NSCs. Group: Biochemicals. Grades: Highly Purified. CAS No. 66575-29-9. Pack Sizes: 1mg, 5mg, 25mg, 50mg. US Biological Life Sciences. | Worldwide |
Forskolin (Coleus forskohlii) Quick inquiry Where to buy Suppliers range | The major cell-permeable diterpene isolated from the Indian plant Coleus forskohlii. At low doses, it acts as a positive inotropic agent. At higher doses, it serves as a hypotensive and vasodilatory agent due to its actions as a smooth muscle relaxant. No major side effects are observed at effective doses. Forskolins pharmacological activities are due to its activation of adenylate cyclase (EC50 = 4uM), resulting in increased cAMP levels. The exact mechanism of forskolins positive inotropic effect is unknown but may be related to a cAMP-dependent increase in Na+ permeability that results in indirect augmentation of Ca2+ release. Inhibits MAP kinase in rat renal mesangial cells (IC50 = 25uM). Also acts as a Hh pathway antagonist. Shown to inhibit apoptosis in cerebellar granule cells and to induce apoptosis in resting human B lymphocytes. Group: Biochemicals. Grades: Highly Purified. CAS No. 66575-29-9. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
Forskolin, Coleus forskohlii (7b-Acetoxy-8,13-epoxy-1α,6 β,9α-trihydroxy-labd-14-en-11-one, Colforsin) Quick inquiry Where to buy Suppliers range | The major cell-permeable diterpene isolated from the Indian plant Coleus forskohlii. At low doses, it acts as a positive inotropic agent. At higher doses, it serves as a hypotensive and vasodilatory agent due to its actions as a smooth muscle relaxant. No major side effects are observed at effective doses. Forskolins pharmacological activities are due to its activation of adenylate cyclase (EC50=4uM), resulting in increased cAMP levels. The exact mechanism of forskolins positive inotropic effect is unknown but may be related to a cAMP-dependent increase in Na+ permeability that results in indirect augmentation of Ca2+ release. Inhibits MAP kinase in rat renal mesangial cells (IC50= 25uM). Also acts as a Hh pathway antagonist. Shown to inhibit apoptosis in cerebellar granule cells and to induce apoptosis in resting human B lymphocytes. Group: Biochemicals. Grades: Highly Purified. CAS No. 66575-29-9. Pack Sizes: 10mg, 25mg. Molecular Formula: C??H??O?. US Biological Life Sciences. | Worldwide |
Guanosine 5'-O-(2-thiodiphosphate) trilithium salt Quick inquiry Where to buy Suppliers range | Non-hydrolyzable GDP analog that competitively inhibits G-protein activation by GTP and GTP analogs. Stimulates adenylate cyclase activity in sarcolemmal membranes by inactivating Gi proteins. Group: Biochemicals. Alternative Names: Guanosine 5?- β-thiodiphosphate trilithium salt; GDP- β-S; GDP- β-S-Li3; GDP βS trilithium salt. Grades: Highly Purified. CAS No. 97952-36-8. Pack Sizes: 1mg, 5mg, 10mg, 25mg. Molecular Formula: C??H??Li?N?O??P?S, Molecular Weight: 477.07. US Biological Life Sciences. | Worldwide |
KH 7 Quick inquiry Where to buy Suppliers range | KH 7 is a novel and selective inhibitor of soluble adenylyl cyclase (Sac) with IC50 value of 3 - 10 μM in vivo, which is an essential component of cAMP-signaling and is ubiquitously expressed. It blocks cAMP synthesis and shows an antiapoptotic effect at concentrations of 1 - 100 μM. Synonyms: KH7; KH 7; KH-7; (E)-2-(1H-Benzo[d]imidazol-2-ylthio)-N'-(5-bromo-2-hydroxybenzylidene)propanehydrazide; 2-(1H-Benzoimidazol-2-ylsulfanyl)-propionic acid (5-bromo-2-hydroxy-benzylidene)-hydrazide; (±)-2-(1H-benzimidazol-2-ylthio)propanoic acid 2-[(5-bromo-2-hydroxyphenyl)methylene]hydrazide. Grades: ≥99% by HPLC. CAS No. 330676-02-3. Molecular formula: C17H15BrN4O2S. Mole weight: 419.30. | |
L-858,051 hydrochloride Quick inquiry Where to buy Suppliers range | L-858,051 is a water-soluble analog of forskolin that acts as an adenylate cyclase activator. It inhibited the 5-HT-stimulated inositol phosphate (IP) accumulation in canine cultured aorta smooth muscle cells (ASMCs). Synonyms: [(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl] 4-(4-methylpiperazin-1-yl)butanoate dihydrochloride. Grades: ≥95%. CAS No. 115116-37-5. Molecular formula: C29H50N2O8·2HCl. Mole weight: 609.6. | |
L-(-)-Epinephrine-(+)-bitartrate (1-(3,4-Dihydroxyphenyl)-2-(methylamino)ethanol) Quick inquiry Where to buy Suppliers range | a,b-Adrenergic receptor agonist. Has positive chronotropic and inotropic effects on heart muscle. Activates adenylate cyclase to generate cAMP from ATP. Group: Biochemicals. Grades: Highly Purified. CAS No. 51-42-3. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
Levalbuterol Quick inquiry Where to buy Suppliers range | Levalbuterol is a short-acting beta 2 adrenergic agonist. Levalbuterol binds to beta 2 adrenergic receptors and activates intracellular adenyl cyclase to promote the convertion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cAMP). It is used to treat wheezing and shortness of breath caused by breathing problems (such as asthma, chronic obstructive pulmonary disease). Uses: The treatment of asthma. Synonyms: Levosalbutamol; (-)-Salbutamol; (-)-Albuterol; R-Salbutamol; 4-[(1R)-2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol. CAS No. 34391-04-3. Molecular formula: C13H21NO3. Mole weight: 239.315. | |
LRE1 Quick inquiry Where to buy Suppliers range | LRE1 is an allosteric soluble adenylyl cyclase (sAC)-specific inhibitor (IC50 value ≤ 10μM) that prevents sAC-dependent processes in cellular and physiological systems via occupying the binding site of the physiological activator HCO3-. LRE1 also inhibits cAMP accumulation in 4-4 cells (IC50 value 11 μM). Synonyms: 6-Chloro-N4-cyclopropyl-N4-(2-thienylmethyl)-2,4-pyrimidinediamine; RU0204277; LRE1; RU 0204277; LRE 1; RU-0204277; LRE-1. Grades: 98%. CAS No. 1252362-53-0. Molecular formula: C12H13ClN4S. Mole weight: 280.78. | |
MDL 12330A hydrochloride Quick inquiry Where to buy Suppliers range | MDL 12330A is an adenylyl cyclase inhibitor. It can also inhibit cAMP and cGMP phosphodiesterases, and block slow extracellular and store-operated Ca2+ entry into cells. MDL 12330A can be used to investigate the role of the adenylyl cyclase/cAMP signaling pathway. Synonyms: MDL-12330A; MDL 12330A; MDL12330A; MDL-12330-A; MDL 12330 A; (±)-N-[(1R*,2R*)-2-Phenylcyclopentyl]-azacyclotridec-1-en-2-amine hydrochloride. Grades: ≥98% by HPLC. CAS No. 40297-09-4. Molecular formula: C23H36N2.HCl. Mole weight: 377.01. | |
MS 15203 Quick inquiry Where to buy Suppliers range | MS 15203 is a potent and selective GPR171 partial agonist (EC50 = 90 nM; 28% inhibition of forskolin activated adenylyl cyclase activity in rat hypothalamic memebranes). It has also been shown to increases neuronal activity in the paraventricular nucleus, and to ncrease food intake and body weight in mice. Synonyms: MS0015203; MS-0015203; MS 0015203; 5-[(2-Methyl-1-oxo-2-propen-1-yl)amino]-1,3-benzenedicarboxylic acid. Grades: ≥98% by HPLC. CAS No. 73912-52-4. Molecular formula: C12H11NO5. Mole weight: 249.22. | |
MTEP hydrochloride Quick inquiry Where to buy Suppliers range | Glutamate, the major excitatory neurotransmitter in the brain, acts on both ionotropic and metabotropic glutamate receptors. Excessive metabotropic glutamate receptor (mGluR) transmission has been linked to epilepsy, ischemia, pain, anxiety, and depression. Eight subtypes (1-8) and multiple splice variants of the mGluR have been identified and grouped based on their pharmacological properties. Group I mGluRs (subtypes 1 and 5) activate the phosphatidyl inositol pathway, while Group II (2 and 3) and Group III (4, 6, 7, and 8) inhibit adenylyl cyclase. MTEP is a negative allosteric modulator of the mGlu5a receptor subtype (Ki = 42 nM; IC50=110 nM). MTEP at 0.3 mg/kg produces antidepressant effects in several rodent models of depression. It also demonstrates neuroprotective potential by preventing excitotoxic neuronal damage when administered through either intrahippocampal or intraperitoneal injection. Additionally, MTEP demonstrates an anxiolytic-like phenotype in rodent models similar to that of benzodiazepines while lacking undesirable sedative and addictive effects. Synonyms: 3-((2-Methyl-1,3-thiazol-4-yl)ethyn-yl)pyridine hydrochloride; MTEP. Grades: >98%. CAS No. 1186195-60-7. Molecular formula: C11H9ClN2S. Mole weight: 236.72. | |
N6-Propargyladenosine-5'-triphosphate sodium salt Quick inquiry Where to buy Suppliers range | N6-Propargyladenosine-5'-triphosphate sodium salt is a fundamental constituent in the realm of biomedical research, exhibiting its remarkable prowess as a formidable adenylyl cyclase inhibitor, thereby assisting in the meticulous exploration of cyclic AMP-dependent pathways. Its prevalent utilization encompasses delving into intricate signal transduction mechanisms, as well as unraveling the multifaceted involvement of adenosine triphosphate (ATP) in diverse cellular processes. Synonyms: N6-Propargyl-ATP. Molecular formula: C13H14N5Na4O13P3. Mole weight: 633.16. | |
NKH 477 Quick inquiry Where to buy Suppliers range | NKH 477 is a water-soluble analog of Forskolin, that is a potent activator of adenylyl cyclase, which shows some selectivity for cardiac (type V) adenylyl cyclase). Group: Biochemicals. Alternative Names: N,N-Dimethyl- β-alanine (3R, 4aR, 5S, 6S, 6aS, 10S, 10aR, 10bS)-5-(Acetyloxy)-3-ethenyldodecahydro-10, 10b-dihydroxy-3, 4a, 7, 7, 10a-pentamethyl-1-oxo-1H-naphtho[2, 1-b]pyran-6-yl Ester HCl; N,N-Dimethyl- β-alanine [3R-(3α,4a β,5 β,6 β, 6aα, 10α, 10a β,10bα)]-5-(Acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-yl Ester HCl; 1H-Naphtho[2,1-b]pyran, β-alanine deriv.; 6- (3-Di methyl aminopropionyl) forskolin HCl; Adehl; Colforsin Dapropate HCl. Grades: Highly Purified. CAS No. 138605-00-2. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C??H??ClNO?, Molecular Weight: 546.09. US Biological Life Sciences. | Worldwide |
NKH 477 Quick inquiry Where to buy Suppliers range | NKH477 is a water-soluble analog of forskolin, which is an adenylyl cyclase activator, but it is sparingly soluble in aqueous solutions. It has both inotropic and vasodilator effects. Uses: Vasodilator agents. Synonyms: NKH 477; NKH477; NKH-477; N,N-Dimethyl-(3R,4aR,5S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-yl ester β-alanine hydrochloride. Grades: ≥98% by HPLC. CAS No. 138605-00-2. Molecular formula: C27H43NO8.HCl. Mole weight: 546.1. | |
NKY 80 Quick inquiry Where to buy Suppliers range | NKY80 is a selective inhibitor of adenylyl cyclase 5 with IC50 value of 8.3 μM. Synonyms: NKY80; NKY 80; NKY-80. 2-Amino-7-(2-furanyl)-7,8-dihydro-5(6H)-quinazolinone. Grades: ≥98% by HPLC. CAS No. 299442-43-6. Molecular formula: C12H11N3O2. Mole weight: 229.23. | |
Orciprenaline Quick inquiry Where to buy Suppliers range | Orciprenaline is a moderately selective beta-adrenergic agonist used in the treatment of asthma and bronchospasms. It stimulates receptors of the smooth muscle in the lungs, uterus, and vasculature supplying skeletal muscle, with minimal or no effect on alpha-adrenergic receptors. It is believed to work by activating adenylate cyclase, the enzyme responsible for producing the cellular mediator cAMP. It was developed by Boehringer-Ingelheim and has been withdraw from the market. Uses: Orciprenaline is used in the treatment of asthma and bronchospasms. Synonyms: Metaproterenol;Alupent;Metaprel;5-[1-Hydroxy-2-(propan-2-ylamino)ethyl]benzene-1,3-diol;Astmopent;1-(3,5-dihydroxyphenyl)-2-isopropylaminoethanol;1,3-Benzenediol, 5-1-hydroxy-2-(1-methylethyl)aminoethyl-;3,5-Dihydroxy-a-[(isopropylamino)methyl]benzyl alco. Grades: 95%. CAS No. 586-06-1. Molecular formula: C11H17NO3. Mole weight: 211.26. |