Amide Hydrolase Suppliers USA
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Product | Description | |
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FAAH Inhibitor III, URB937 (Cyclohexylcarbamic acid-(3-carbamoyl-6-hydroxybiphenyl-3-yl)ester, Fatty Acid Amide Hydrolase Inhibitor III, URB937, Cyclohexylcarbamic acid-carbamoyl hydroxybiphenyl-3-yl) ester) Quick inquiry Where to buy Suppliers range | A blood-brain-barrier impermeable p-hydroxyphenylcarbamate compound that acts as a potent and irreversible inhibitor of FAAH activity (IC50 = 26.8nM rat brain) with excellent selectivity over monoacylglycerol lipases (IC50 > 100uM). Shown to rapidly block mouse liver FAAH activity over brain (ED50 = 0.2mg/kg vs. 40mg/kg, s.c.), elevate anandamide and palmitoylethanolamide levels in peripheral tissues (1mg/kg, i.p.) and exert antinociceptive action. The CNS-penetrant FAAH Inhibitor II, URB597 is also available. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
15(S)-HETE ethanolamide Quick inquiry Where to buy Suppliers range | Arachidonoyl ethanolamide (AEA) was the first endogenous cannabinoid (CB) to be isolated and characterized as an agonist acting on the same receptors (CB1 and CB2) as THC. 15(S)-HETE ethanolamide is less potent than AEA at the CB1 receptor (Ki of 600 versus 90 nM). 15(S)-HETE ethanolamide also inhibits fatty acid amide hydrolase. Synonyms: 15(S)-hydroxy-N-(2-hydroxyethyl)-5Z,8Z,11Z,13E-eicosatetraenamide; 15(S)-HAEA. Grades: >98%. CAS No. 161744-53-2. Molecular formula: C22H37NO3. Mole weight: 363.5. | |
(±)17(18)-EpETE-Ethanolamide Quick inquiry Where to buy Suppliers range | (±)17(18)-EpETE-Ethanolamide is an ω-3 endocannabinoid epoxide. It is formed from the endocannabinoid eicosapentaenoic ethanolamide (EPEA) via cytochrome P450 (CYP) epoxygenases and hydrolyzed by soluble epoxide hydrolase (sEH) and fatty acid amide hydrolase (FAAH). Synonyms: 17,18-EEQ-EA; (±)17,18-EEQ-Ethanolamide; (±)17(18)-EpETE-EA; 17,18-epoxy-Eicosatetraenoic Acid Ethanolamide. Grades: ≥98%. CAS No. 2123491-23-4. Molecular formula: C22H35NO3. Mole weight: 361.5. | |
1-Fluoro-2-iodoethane Quick inquiry Where to buy Suppliers range | 1-Fluoro-2-iodoethane is used as a reagent in organic synthesis of several compounds including that of fluorinated U-50488 analogs for PET studies of kappa opioid receptors. It is also used in the synthesis of MK-3168, an imidazole analog which acts as a PET tracer for the imaging of brain fatty acid amide hydrolase. Group: Biochemicals. Grades: Highly Purified. CAS No. 762-51-6. Pack Sizes: 1g, 5g. Molecular Formula: C2H4FI, Molecular Weight: 173.96. US Biological Life Sciences. | Worldwide |
2,2,2-Trichloroethyl Chloroformate Quick inquiry Where to buy Suppliers range | 2,2,2-Trichloroethyl Chloroformate is a general reagent for the demethylation of tertiary methylamines. It is used as a reagent in the synthesis of a series of piperazine ureas as fatty acid amide hydrolase inhibitors and analgesics. Also used as a reagent in the synthesis of pyrazolo[3,4-d]pyrimidine derivatives as GPR119 agonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 17341-93-4. Pack Sizes: 1g, 10 g. Molecular Formula: C3H2Cl4O2. US Biological Life Sciences. | Worldwide |
2-Amino-1-(4-phenoxyphenyl)ethanol Quick inquiry Where to buy Suppliers range | 2-Amino-1-(4-phenoxyphenyl)ethanol is used as a reagent in the synthesis of (4-phenoxyphenyl) tetrazolecarboxamides and its related compounds as dual inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL). Group: Biochemicals. Grades: Highly Purified. CAS No. 153285-74-6. Pack Sizes: 100mg, 1g. Molecular Formula: C14H15NO2, Molecular Weight: 229.27. US Biological Life Sciences. | Worldwide |
2-Amino-1-[4- (trifluoromethoxy) phenyl]ethanol Quick inquiry Where to buy Suppliers range | 2-Amino-1-[4- (trifluoromethoxy) phenyl]ethanol is used to prepare heteroaryl derivatives such as 4-aminopyrimidine derivatives as fatty acid amide hydrolase (FAAH) inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 1038262-63-3. Pack Sizes: 100mg, 1g. Molecular Formula: C9H10F3NO2, Molecular Weight: 221.18. US Biological Life Sciences. | Worldwide |
2-Carboxyethylboronic Acid, Pinacol Ester Quick inquiry Where to buy Suppliers range | 2-Carboxyethylboronic Acid, pinacol ester acts as a reagent in the preparation of oxadiazolylphenyl Boronic acid derivatives and analogs for use as fatty acid amide hydrolase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 1191063-90-7. Pack Sizes: 100mg, 250mg. Molecular Formula: C9H17BO4, Molecular Weight: 200.04. US Biological Life Sciences. | Worldwide |
(2E)-3-(4-Phenoxyphenyl)-2-propenoic Acid Ethyl Ester Quick inquiry Where to buy Suppliers range | (2E)-3-(4-Phenoxyphenyl)-2-propenoic Acid Ethyl Ester is used as a reagent to evaluate structure-activity relationships of ketooxazole inhibitors of fatty acid amide hydrolase. Group: Biochemicals. Grades: Highly Purified. CAS No. 945414-28-8. Pack Sizes: 1g, 10g. Molecular Formula: C17H16O3, Molecular Weight: 268.31. US Biological Life Sciences. | Worldwide |
2- (Tributylstannyl) oxazole Quick inquiry Where to buy Suppliers range | 2- (Tributylstannyl) oxazole is a useful reactant in preparation of potent, selective and efficacious reversible α-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics. Group: Biochemicals. Grades: Highly Purified. CAS No. 145214-05-7. Pack Sizes: 100mg, 250mg. Molecular Formula: C15H29NOSn, Molecular Weight: 358.11. US Biological Life Sciences. | Worldwide |
3-Cyanobenzeneboronic acid Quick inquiry Where to buy Suppliers range | 3-Cyanophenylboronic acid is a novel fatty acid amide hydrolase inhibitor. Synonyms: B-(3-Cyanophenyl)boronic Acid; (m-Cyanophenyl)boronic Acid; 3-Cyanobenzeneboronic Acid; 3-Cyanophenylboronic Acid; 3-Boronobenzonitrile; Boronic acid, B-(3-cyanophenyl)-; 3-(dihydroxyboranyl)benzonitrile; ACMC-1C8U1; 3-Cyano Phenyl Boronic Acid. Grades: > 98 % (HPLC). CAS No. 150255-96-2. Molecular formula: C7H6BNO2. Mole weight: 146.94. | |
3- (Trifluoromethyl) phenyl Chloroformate Quick inquiry Where to buy Suppliers range | 3- (Trifluoromethyl) phenyl Chloroformate is a reagent in the preparation of tetrahydro- β-carboline derivatives which targets fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channels. Group: Biochemicals. Grades: Highly Purified. CAS No. 95668-29-4. Pack Sizes: 250mg, 500mg. Molecular Formula: C8H4ClF3O2, Molecular Weight: 224.56. US Biological Life Sciences. | Worldwide |
4-(n-nonyl) benzeneboronic acid Quick inquiry Where to buy Suppliers range | Fatty acid amide hydrolase (FAAH) is the primary enzyme responsible for the hydrolysis of the endocannabinoid arachidonoyl ethanolamide (AEA). 4-(n-nonyl) benzeneboronic acid is a potent inhibitor of FAAH, with an IC50 of 9.1 nM. Synonyms: 4-Nonylphenylboronic acid; (4-nonylphenyl)boronic acid. Grades: ≥98%. CAS No. 256383-45-6. Molecular formula: C15H25BO2. Mole weight: 248.2. | |
(±)5(6)-EET Ethanolamide Quick inquiry Where to buy Suppliers range | Arachidonyl ethanolamide (AEA) is an endogenous lipid neurotransmitter with cannabinergic activity. It binds to both the central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. Fatty acid amide hydrolase (FAAH) is the enzyme responsible for hydrolysis and inactivation of AEA. Synonyms: (±)5,6-EpETrE Ethanolamide; N-(2-hydroxyethyl)-4-[(2S,3R)-3-[(2Z,5Z,8Z)-tetradeca-2,5,8-trienyl]oxiran-2-yl]butanamide. Grades: ≥95%. Molecular formula: C22H37NO3. Mole weight: 363.5. | |
AACOCF Quick inquiry Where to buy Suppliers range | AACOCF, an anlogue of arachidonic acid, is a slow-binding inhibitor of cytosolic (85 kDa) phospholipase A2. It also inhibits fatty acid amide hydrolase (FAAH, anandamide amidase) in vitro. Synonyms: 1,1,1-Trifluoro-6Z,9Z,12Z,15Z-heneicosateraen-2-one; Arachidonyl trifluoromethyl ketone; Arachidonyltrifluoromethane. CAS No. 149301-79-1. Molecular formula: C21H31F3O. Mole weight: 356.47. | |
Ac-Nle-Pro-Nle-Asp-AMC Quick inquiry Where to buy Suppliers range | Ac-Nle-Pro-Nle-Asp-AMC is a substrate for proteasomes. It can be cleaved by the caspase-like site of proteasome, also known as postglutamyl peptide hydrolase (PGPH). AMC (7-amino-4-methylcoumarin) is released and produces the fluorescence utilized to quantify the caspase-like site activity. Ac-Nle-Pro-Nle-Asp-AMC also inhibits the chymotrypsin-like activity of the proteasome allosterically when bound to the caspase-like site. Synonyms: Ac-Nle-Pro-Nle-Asp-7-amido-4-Methylcoumarin; Ac-nLPnLD-AMC; N-acetyl-L-norleucyl-L-prolyl-L-norleucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-α-asparagine; L-α-Asparagine, N-acetyl-L-norleucyl-L-prolyl-L-norleucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-; (3S) -4-Hydroxy-3- ({ (2S) -1-hydroxy-2-[ (hydroxy{ (2S) -1-[N- (1-hydroxyethylidene) -L-norleucyl]-2-pyrrolidinyl}methylene) amino]hexylidene}amino) -4-[ (4-methyl-2-oxo-2H-chromen-7-yl) imino]butanoic acid. Grades: ≥98%. CAS No. 355140-49-7. Molecular formula: C33H45N5O9. Mole weight: 655.74. | |
AM3102 Quick inquiry Where to buy Suppliers range | AM-3102 is an Oleoyl ethanolamide (OEA) analog that stimulates PPARα transcriptional activity with an EC50 value of 100 nM and prolongs feeding latency. The biological effects of OEA are terminated by N-acylethanolamine-hydrolyzing acid amidase and fatty-acid amide hydrolase. AM3102 demonstrates weak affinity for the central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors with Ki values of 33 and 26 μM, respectively. Synonyms: KDS-5104; AM-3102; AM 3102; Methyl oleoylethanolamide. Grades: ≥98%. CAS No. 213182-22-0. Molecular formula: C21H41NO2. Mole weight: 339.6. | |
AM404 Quick inquiry Where to buy Suppliers range | AM-404 is a selective inhibitor of the carrier-mediated transport of anandamide without affecting anandamide hydrolysis. AEM is also an analog of arachidonyl ethanolamide (AEA) which potentiates the activity of endogenous AEA by blocking its reuptake into presynaptic neurons. AM404 inhibits endocannabinoid cellular uptake, binds weakly to CB1 and CB2 cannabinoid receptors, and is formed by fatty acid amide hydrolase (FAAH) in vivo. Synonyms: 5,8,11,14-Eicosatetraenamide, N-(4-hydroxyphenyl)-, (5Z,8Z,11Z,14Z)-; (5Z,8Z,11Z,14Z)-N-(4-Hydroxyphenyl)-5,8,11,14-eicosatetraenamide; 5,8,11,14-Eicosatetraenamide, N-(4-hydroxyphenyl)-, (all-Z)-; AM 404; AM404. Grades: ≥98%. CAS No. 183718-77-6. Molecular formula: C26H37NO2. Mole weight: 395.58. | |
Arachidonyl serotonin Quick inquiry Where to buy Suppliers range | Arachidonyl serotonin is a dual target agent of transient receptor potential vanilloid-type I (TRPV1) antagonist and fatty acid amide hydrolase (FAAH) inhibitor, which is responsible for inactivation of anandamide and other endogenous cannabinoids. Its IC50 values are 37-40 nM and 5.6 μM for TRPV1 and FAAH respectively. It inhibits the FAAH activity isolated from mouse neuroblastoma cells with an IC50 value of 12 μM. It is a very tight binding, competitive inhibitor of FAAH. It does not inhibit cPLA2 and is essentially devoid of cannabimimetic activity. It was shown to be present in the ileum and jejunum of the gastrointestinal tract and modulate glucagon-like peptide-1 (GLP-1) secretion. It displays strong analgesic activity against both acute and chronic peripheral pain in rodents. Synonyms: AA-5HT; AA5HT; AA 5HT; N-arachidonoyl-serotonin; Arachidonoyl serotonin; N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-5Z,8Z,11Z,14Z-eicosatetraenamide; AA-5HT; AA5HT; N-arachidonoyl-serotonin; N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-5,8,11,14-eicosatetraenamide; (5Z,8Z,11Z,14Z)-N-(2-(5-hydroxy-1H-indol-3-yl)ethyl)icosa-5,8,11,14-tetraenamide. CAS No. 187947-37-1. Molecular formula: C30H42N2O2. Mole weight: 462.67. | |
ARN726 Quick inquiry Where to buy Suppliers range | ARN726 is a systemically active and orally bioavailable N-acylethanolamine acid amidase (NAAA) inhibitor with IC50 value of 27 nM for human and 63 nM for rat NAAA. The selectivity for NAAA is better than fatty acid amide hydrolase (FAAH) with IC50s of 100 uM. It is also selective over acid cermidase with IC5Os of 12.5 uM. ARN726 can decrease lung myeloperoxidase activity and pleural exudate TNF-α levels in a mouse model of carrageenan-induced lung inflammation. Synonyms: ARN-0726; ARN 0726. Grades: ≥95%. CAS No. 1628343-77-0. Molecular formula: C14H24N2O3. Mole weight: 268.35. | |
BIA10-2474 Quick inquiry Where to buy Suppliers range | This active molecular is a reversible FAAH (fatty acid amide hydrolase) inhibitor that increases levels of the neurotransmitter anandamide in the central nervous system and in peripheral tissues (except the brain and spinal cord) under the development of Bial-Portela & Ca. SA. BIA 10-2474 can interact with the human endocannabinoid system and was inpplicated in the treatment of a range of different medical conditions including anxiety, Parkinson's disease, chronic pain of multiple sclerosis, cancer, hypertension and obesity. Clinical trial with BIA 10-2474 was on-going. However, severe adverse events occurred in January 2016 affecting 5 patients, including leading to the death of one. Uses: Neurological disorders; pain; psychiatric disorders. Synonyms: BIA 10-2474; BIA-10-2474; BIA10-2474; N-cyclohexyl-N-methyl-4-(1-oxidopyridin-1-ium-3-yl)imidazole-1-carboxamide;UNII-5AP1ZW859M; SCHEMBL427970; 5AP1ZW859M; GTPL9001; DOWVMJFBDGWVML-UHFFFAOYSA-N. Grades: 98%. CAS No. 1233855-46-3. Molecular formula: C16H20N4O2. Mole weight: 300.36. | |
CAY10401 Quick inquiry Where to buy Suppliers range | Fatty acid amide hydrolase (FAAH) is the enzyme responsible for hydrolysis and inactivation of fatty acid amides including anandamide and oleamide. CAY10401 is a selective, potent inhibitor of rat FAAH exhibiting a Ki value of 0.14 nM. It is approximately 580-fold more potent than oleyl trifluoromethyl ketone. Synonyms: CAY 10401; CAY-10401; 1-oxazolo[4,5-b]pyridin-2-yl-9-octadecyn-1-one. Grades: ≥98%. CAS No. 288862-89-5. Molecular formula: C24H34N2O2. Mole weight: 382.5. | |
CAY10435 Quick inquiry Where to buy Suppliers range | Fatty acid amide hydrolase (FAAH) is the enzyme responsible for hydrolysis and inactivation of fatty acid amides including anandamide and oleamide. CAY10435 is a selective, potent inhibitor of rat FAAH with Ki value of 0.57 nM. It exhibited IC50 values of 0.81 nM, 83 nM, and 50 μM for FAAH, triacylglycerol hydrolase (TGH), and an uncharacterized hydrolase (KIAA1363), respectively. Synonyms: CAY 10435; CAY-10435. Grades: ≥98%. CAS No. 288862-73-7. Molecular formula: C18H26N2O2. Mole weight: 302.4. | |
CAY10570 Quick inquiry Where to buy Suppliers range | Fatty acid amide hydrolase (FAAH) is the enzyme responsible for hydrolysis and inactivation of fatty acid amides including anandamide and oleamide. CAY10570 is a reversible competitive inhibitor of FAAH activity exhibiting an IC50 value of 1.3 μM. It has no affinity for the human CB1 receptor and acts as a competitive inhibitor of FAAH activity without being hydrolyzed. Synonyms: CAY 10570; CAY-10570. Grades: >98%. CAS No. 875014-22-5. Molecular formula: C25H32N2OS. Mole weight: 408.6. | |
Cephalosporinase Quick inquiry Where to buy Suppliers range | Cephalosporinase. Group: Heterocyclic Organic Compound. Alternative Names: PENICILLIN AMIDO-BETA-LACTAMHYDROLASE;PENICILLIN AMIDO-BETA-LACTAM HYDROLASE TYPE I;PENICILLIN AMIDO-BETA-LACTAM HYDROLASE TYPE II;PENICILLIN AMIDO-BETA-LACTAM HYDROLASE TYPE III;PENICILLIN AMIDO-BETA-LACTAM HYDROLASE TYPE IV;PENICILLINASE TYPE I;PENICIL. CAS No. 9012-26-4. | |
Elaidamide Quick inquiry Where to buy Suppliers range | Elaidamide has been found in the cerebrospinal fluid of sleep-deprived cats. Elaidamide is a fatty acid amide that inhibits rat microsomal epoxide hydrolase (mEH; Ki = 70 nM) and porcine pancreatic and human synovial phospholipase A2 (PLA2). Uses: Food additives. Synonyms: Elaidoylamide; (E)-9,10-Octadecenamide; 9E-octadecenamide. Grades: ≥95%. CAS No. 4303-70-2. Molecular formula: C18H35NO. Mole weight: 281.5. | |
JNJ-1661010 Quick inquiry Where to buy Suppliers range | JNJ-1661010 is a potent and selective fatty acid amide hydrolase (FAAH) inhibitor with IC50 of 10 nM (rat) and 12 nM (human), exhibits >100-fold selectivity for FAAH-1 when compared to FAAH-2. Synonyms: Takeda-25; N1-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide; JNJ 1661010; JNJ1661010; N-Phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinecarboxamide. Grades: ≥98%. CAS No. 681136-29-8. Molecular formula: C19H19N5OS. Mole weight: 365.45. | |
JNJ-40355003 Quick inquiry Where to buy Suppliers range | JNJ-40355003 is a selective fatty acid amide hydrolase (FAAH) inhibitor. JNJ-40355003 can elevate the plasma levels of anandamide, oleoyl ethanolamide, and palmitoyl ethanolamide in animal model. Synonyms: JNJ-40355003; JNJ 40355003; JNJ40355003; 4-((3-(4-chlorophenoxy)phenyl)methyl)-N-3-pyridinyl-1-Piperazinecarboxamide. Grades: 98%. CAS No. 1394894-41-7. Molecular formula: C23H23ClN4O2. Mole weight: 422.91. | |
JNJ-42165279 Quick inquiry Where to buy Suppliers range | JNJ-42165279 is a fatty acid amide hydrolase (FAAH) inhibitor developed by Janssen Pharmaceutica and IC50 value is 70 nM. It is described as a covalently binding but slowly reversible selective inhibitor of FAAH. Phase II human trials for the treatment of anxiety disorders and major depressive disorder is on-going. Uses: Anxiety disorders and major depressive disorder. Synonyms: N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)methyl)piperazine-1-carboxamide; JNJ-42165279; JNJ 42165279; JNJ42165279. Grades: 98%. CAS No. 1346528-50-4. Molecular formula: C18H17ClF2N4O3. Mole weight: 410.81. | |
JNJ-42165279 hydrochloride Quick inquiry Where to buy Suppliers range | JNJ-42165279 is a potent and selective fatty acid amide hydrolase (FAAH) inhibitor. JNJ-42165279 covalently inactivates the FAAH enzyme, but is highly selective with regard to other enzymes, ion channels, transporters, and receptors. Synonyms: JNJ-42165279 hydrochloride; JNJ 42165279 hydrochloride; JNJ42165279 hydrochloride; 1-Piperazinecarboxamid?e, N-(4-chloro-3-pyridinyl)?-4-[(2,?2-difluoro-1,?3-benzodioxol-5-yl)?methyl]?-, hydrochloride (1:1). CAS No. 1346528-52-6. Molecular formula: C18H17ClF2N4O3. HCl. Mole weight: 447.3. | |
JP104 Quick inquiry Where to buy Suppliers range | JP104 is an irreversible fatty acid amide hydrolase (FAAH) inhibitor. JP104 is in the carbamate class with an IC50 of 7.3 nM for the human recombinant enzyme when tested using radiolabeled oleamide as the substrate. Synonyms: 3'-Carbamoyl-biphenyl-3-yl-undecynecarbamate. Grades: ≥98%. CAS No. 887264-45-1. Molecular formula: C25H30N2O3. Mole weight: 406.5. | |
JP83 Quick inquiry Where to buy Suppliers range | JP83 is an irreversible fatty acyl amide hydrolase (FAAH) inhibitor. JP83 is in the carbamate class with an IC50 of 14 nM for the human recombinant enzyme when tested using radiolabeled oleamide as the substrate. Synonyms: 3'-Carbamoyl-biphenyl-3-yl-hexylphenylcarbamate. Grades: ≥98%. CAS No. 887264-44-0. Molecular formula: C26H28N2O3. Mole weight: 416.5. | |
JW 642 Quick inquiry Where to buy Suppliers range | Endocannabinoids such as 2-arachidonoyl glycerol (2-AG) and arachidonoyl ethanolamide are biologically active lipids that are involved in a number of synaptic processes including activation of cannabinoid receptors. Monoacylglycerol lipase (MAGL) is a serine hydrolase responsible for the hydrolysis of 2-AG to arachidonic acid and glycerol, thus terminating its biological function. JW 642 is a potent inhibitor of monoacylglycerol lipase (MAGL) that displays IC50 values of 7.6, 14, and 3.7 nM for inhibition of MAGL in mouse, rat, and human brain membranes, respectively. JW 642 is selective for MAGL, requiring much higher concentrations to effectively inhibit fatty acid amide hydrolase activity (IC50s = 31, 14, and 20.6 μM for mouse, rat, and human brain membranes, respectively). Synonyms: JW642; JW-642; JW 642. Grades: >98%. CAS No. 1416133-89-5. Molecular formula: C21H20F6N2O3. Mole weight: 462.39. | |
JZL195 Quick inquiry Where to buy Suppliers range | JZL195 is a potent dual inhibitor of Monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH), enzymes that degrade the endocannabinoids 2-arachidonoylglycerol (2-AG) and anandamide (AEA), the endogenous ligands for the cannabinoid G-protein coupled receptors CB1 and CB2. IC50 values are 2 nM for MAGL and 4 nM for FAAH. JZL195 has been shown to inhibit endocannabinoid hydrolysis and elevate 2-AG and AEA levels in vivo. Synonyms: JZL195; JZL-195; JZL 195. Grades: >98%. CAS No. 1210004-12-8. Molecular formula: C24H23N3O5. Mole weight: 433.46. | |
LY2183240 Quick inquiry Where to buy Suppliers range | LY2183240 is a novel and highly potent blocker of anandamide uptake. It inhibits fatty acid amide hydrolase (FAAH) activity. It increases brain anandamide concentration and exerts antinociceptive effects in formalin model of pain. Synonyms: LY2183240; LY-2183240; LY 2183240. Grades: >98%. CAS No. 874902-19-9. Molecular formula: C17H17N5O. Mole weight: 307.35. | |
N-(8Z-Heptadecen-1-yl)-O-(3-pyridylmethyl)carbamate Quick inquiry Where to buy Suppliers range | N-(8Z-Heptadecen-1-yl)-O-(3-pyridylmethyl)carbamate acts as an inhibitor of fatty acid amide hydrolase (FAAH). It decreased cell viability of non-small lung cancer cells A549 and H460 with IC50 of 4.9 and 0.9 μM, respectively. Synonyms: Pyridin-3-ylmethyl N-[(Z)-heptadec-8-enyl]carbamate. Grades: ≥98%. CAS No. 1450603-63-0. Molecular formula: C24H40N2O2. Mole weight: 388.6. | |
N-acetylmuramoyl-L-alanine amidase L2 Quick inquiry Where to buy Suppliers range | N-Acetylmuramoyl-l-alanine amidases are peptidoglycan hydrolases with the specificity to cleave the amide bond between the lactyl group of the muramic acid and the α-amino group of l-alanine, and are able to cause dissolution of the peptidoglycan structure and thus do not exhibit peptidase activity. Synonyms: NAMAA L2. | |
N-Boc-N-methylpiperazine Quick inquiry Where to buy Suppliers range | Used in the preparation of piperazine-1-carboxamide derivatives as fatty acid amide hydrolase (FAAH) inhibitors. Group: Biochemicals. Alternative Names: 4-Methyl-1-piperazinecarboxylic Acid 1,1-Dimethylethyl Ester; 1-Methyl-4- (tert-butoxycarbonyl) piperazine; 4-Methylpiperazine-1-carboxylic Acid tert-Butyl Ester. Grades: Highly Purified. CAS No. 53788-49-1. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
Oleoyl ethyl amide Quick inquiry Where to buy Suppliers range | Oleoyl ethyl amide is a fatty acid amide hydrolase (FAAH) inhibitor with potential analgesic and anxiolytic activity. It altered sensory urodynamic parameters and reduced bladder overactivity in female rats. Synonyms: OEtA; N-Ethyloleamide; (1Z)-N-Ethyloctadec-9-enimidate. Grades: ≥98%. CAS No. 85075-82-7. Molecular formula: C20H39NO. Mole weight: 309.5. | |
Oleoyl oxazolopyridine Quick inquiry Where to buy Suppliers range | Oleoyl oxazolopyridine is a potent inhibitor of fatty acid amide hydrolase (FAAH) with Ki values of 1.3 and 2.3 nM for the human and rat enzymes, respectively. It is approximately 35-fold more potent than oleyl trifluoromethyl ketone when assayed under the same conditions. Synonyms: CAY10400; (Z)-1-([1,3]oxazolo[4,5-b]pyridin-2-yl)octadec-9-en-1-one. Grades: ≥98%. CAS No. 288862-58-8. Molecular formula: C24H36N2O2. Mole weight: 384.6. | |
Palmitoylisopropylamide Quick inquiry Where to buy Suppliers range | Palmitoyl-N-isopropylamide, a synthetic analog of palmitoyl ethanolamide, is an inhibitor of the FAAH (fatty acid amide hydrolase); pIC50 = 4.89 for inhibition of [3H]-anandamide metabolism. It displays little binding to CB1 and CB2 receptors (IC50 > 100 μM) and very weakly blocks anandamide uptake (IC50 ~ 100 μM). Synonyms: N-(1-Methylethyl)-hexadecanamide; PIA. CAS No. 189939-61-5. Molecular formula: C19H39NO. Mole weight: 297.52. | |
PDP-EA Quick inquiry Where to buy Suppliers range | PDP-EA, an activator of fatty acid amide hydrolase (FAAH) from plant and mammalian species, is a FAAH activator, which is proposed to enhance amidohydrolase activity of FAAH by reducing negative feedback mechanisms. Synonyms: N-(2-Hydroxyethyl)-2-(3-pentadecylphenoxy)acetamide. Grades: ≥98% by HPLC. CAS No. 861891-72-7. Molecular formula: C25H43NO3. Mole weight: 405.61. | |
PENICILLINASE Quick inquiry Where to buy Suppliers range | PENICILLINASE. Group: Pheromone Ingredients. Alternative Names: PENICILLIN AMIDO-BETA-LACTAMHYDROLASE;PENICILLIN AMIDO-BETA-LACTAM HYDROLASE TYPE I;PENICILLIN AMIDO-BETA-LACTAM HYDROLASE TYPE II;PENICILLIN AMIDO-BETA-LACTAM HYDROLASE TYPE III;PENICILLIN AMIDO-BETA-LACTAM HYDROLASE TYPE IV;PENICILLINASE TYPE I;PENICIL. CAS No. 9001-74-5. Melting Point: 121-126 °C. | |
PF 3845 Quick inquiry Where to buy Suppliers range | PF 3845 is a selective fatty acid amide hydrolase (FAAH) inhibitor (Ki = 0.23uM). Reduces inflammatory pain via a cannabinoid receptor-dependent mechanism. Highly efficacious and selective in vivo. Displays no activity at FAAH-2 (IC50 >10uM). Group: Biochemicals. Alternative Names: N-3-Pyridinyl-4- [ [3- [ [5- (trifluoromethyl) -2-pyridinyl] oxy] phenyl] methyl] -1-piperidinecarboxamide. Grades: Highly Purified. CAS No. 1196109-52-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
PF 750 Quick inquiry Where to buy Suppliers range | Fatty acid amide hydrolase (FAAH) inhibitor, selectively inhibiting FAAH within the central nervous system. Group: Biochemicals. Alternative Names: N-Phenyl-4-(3-quinolinylmethyl)-1-piperidinecarboxamide; N-Phenyl-4-(quinolin-3-ylmethyl)piperidine-1-carboxamide. Grades: Highly Purified. CAS No. 959151-50-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
SA 47 Quick inquiry Where to buy Suppliers range | SA 47 is a selective fatty acid amide hydrolase (FAAH) inhibitor. Synonyms: SA-47; SA 47; SA47; N-[2-[1-(6-Methyl-2-pyridinyl)-4-piperidinyl]ethyl]carbamic acid 2-(methylamino)-2-oxoethyl ester; [2-(methylamino)-2-oxoethyl] N-[2-[1-(6-methylpyridin-2-yl)piperidin-4-yl]ethyl]carbamate. Grades: ≥99% by HPLC. CAS No. 792236-07-8. Molecular formula: C17H26N4O3. Mole weight: 334.41. | |
SA 57 Quick inquiry Where to buy Suppliers range | SA 57 is a potent fatty acid amide hydrolase (FAAH) inhibitor (IC50 <10 nM), and also inhibits MAGL at higher concentrations (IC50 = 410 nM and 1.4 μM, respectively). Synonyms: SA 57; SA57; SA-57; 4-[2-(4-Chlorophenyl)ethyl]-1-piperidinecarboxylic acid 2-(methylamino)-2-oxoethyl ester; [2-(methylamino)-2-oxoethyl] 4-[2-(4-chlorophenyl)ethyl]piperidine-1-carboxylate. Grades: ≥99% by HPLC. CAS No. 1346169-63-8. Molecular formula: C17H23ClN2O3. Mole weight: 338.83. | |
TC-F 2 Quick inquiry Where to buy Suppliers range | TC-F 2 is a potent, reversible and noncovalent inhibitor of fatty acid amide hydrolase (FAAH) (IC50 = 28 and 100 nM for human and rat FAAH, respectively). Synonyms: 1-[(3S)-1-[4-(2-Benzofuranyl)-2-pyrimidinyl]-3-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one. Grades: ≥99% by HPLC. CAS No. 1304778-15-1. Molecular formula: C26H25N5O2. Mole weight: 439.51. | |
URB602 Quick inquiry Where to buy Suppliers range | URB602, a cell-permeable N-biphenyl carbamate compound, is a selective inhibitor of monoglycerol lipase (MGL). The IC50 = 28 μM and Km = 20 μM. It does not inhibit fatty acid amide hydrolase (FAAH) at concentrations up to 100 μM or other lipid metabolizing enzymes such as diacylglycerol lipase or COX-2. Synonyms: cyclohexyl [1,1'-biphenyl]-3-ylcarbamate; URB602; URB-602; URB 602. CAS No. 565460-15-3. Molecular formula: C19H21NO2. Mole weight: 295.38. | |
URB602 (Biphenyl-3-yl Carbamic Acid, Cyclohexyl Ester) Quick inquiry Where to buy Suppliers range | URB602 is a selective inhibitor of MGL, exhibiting an IC50 of 28 µM for the rat brain enzyme. It does not inhibit fatty acid amide hydrolase (FAAH) at concentrations. Group: Biochemicals. Alternative Names: Biphenyl-3-yl Carbamic Acid, Cyclohexyl Ester. Grades: Highly Purified. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
URB937 Quick inquiry Where to buy Suppliers range | URB937 is a potent, peripheral fatty acid amide hydrolase (FAAH) inhibitor with IC50 value of 26.8 nM. It was shown to reduce prostaglandin E2-induced bladder overactivity and hyperactivity of bladder mechano-afferent nerve fibers in rats. Synonyms: URB-937; URB 937; [3-(3-carbamoylphenyl)-4-hydroxyphenyl] N-cyclohexylcarbamate. Grades: ≥95%. CAS No. 1357160-72-5. Molecular formula: C20H22N2O4. Mole weight: 354.4. |