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2-Ethyl-2-oxazoline is an oxazoline which is used particularly as a monomer for the cationic ring-opening polymerization to poly(2-alkyloxazoline)s. This type of polymers are under investigation as readily water-soluble and biocompatible materials for biomedical applications. Uses: Amine polyoxazolines can be covalently attached through conjugation to carboxyl groups or sulfhydryl groups. amines can also attach to oxidized carbohydrate groups (usually aldehydes) by reductive amination. polyoxazolines are a biocompatible, hydrophilic, amorphous alternatives to poly(ethylene glycol). Group: Hydrophilic polymers. Alternative Names: aminoPEOx, Poly(2-ethyl-2-oxazoline) hydroxyethyl amine, POZ, Polyoxazoline, amino terminated polyoxazoline. Pack Sizes: Packaging 1 g in glass bottle. Molecular formula: average Mn 2,000. Mole weight: CH3(C5H9NO)nNHC2H4OH.
Poly(ethylene oxide), 4-arm, amineterminated
Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation. Uses: Activated peg derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. pegylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of peg improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. in addition to pegylation, activated peg derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity. Group: Poly(ethylene glycol) and poly(ethylene oxide). Molecular formula: average Mn 10000.
Poly(L-lactide), amineterminated
Poly(L-lactide) (PLLA) and its copolymers are among the most studied biodegradable polymers. PLLA is a crystalline polymer with good mechanical properties. The applications of PLLA are mainly concentrated in biomedical applications. Uses: Drug delivery including coating nanoparticles; end-group functionalization; macroinitiator or block precursor. Group: 3d printing materials biodegradable polymers. Alternative Names: amino-PLLA, NH2 PLLA, aminoPLA, Amino-functionalized polylactide, PLA-NH2. Pack Sizes: 1, 5 g in glass bottle. Molecular formula: average Mn 2,500. Mole weight: C3H9NO(C3H4O2)n.
Poly(N-isopropyl acrylamide), amineterminated
The hydrophilic polymer contains polar or charged functional groups, making it soluble in water. Uses: Novel polymer for development of thermosensitive coated micro/nano materials including thermoresponsive polymeric drug delivery systems. the amine functional group can be used to attach a variety of biomolecules to the polymer chain. Group: Hydrophilic polymers. Alternative Names: polyacrylamide, functionalized polyNIPAM, functionalized polyacrylamide, PNIPAM-NH2, NIPAM polymer. Pack Sizes: Packaging 1 g in glass bottle. Molecular formula: average Mn 2,000. Mole weight: H(C6H11NO)n(CH2)NH2.
Poly(N-isopropylacrylamide), amineterminated
The hydrophilic polymer contains polar or charged functional groups, making it soluble in water. Uses: Pnipam-based smart surfaces for cell sheet tissue engineering novel polymer for development of thermosensitive coated micro/nano materials including thermoresponsive polymeric drug delivery systems. the amine functional group can be used to conjugate a variety of biomolecules to the polymer chain. Group: Hydrophilic polymers. Alternative Names: functionalized polyNIPAM, functionalized polyacrylamide, Polyacrylamide, PNIPAM-NH2, NIPAM polymer, polyNIPAM. Pack Sizes: Packaging 1, 5 g in glass bottle. Molecular formula: Mn 2000-3000 (by HCL Titration). Mole weight: (C6H11NO)nSCH2CH2NH2.
Polystyrene is a colorless and transparent thermoplastic, among which expanded polystyrene is commonly known as Styrofoam. Uses: Functional polystyrene with amine termination has been used as a macromolecular surfactant; capable of conjugation with enzymes; proteins and lipases. they are also known to form well-defined assemblies in aqueous solution. Group: Polystyrene (ps). Alternative Names: amino PS, PS NH2, aminopolystyrene. Pack Sizes: 1 g in glass bottle. Molecular formula: average Mn 5,000. Mole weight: (C8H8)nCH5N.
16-Mercaptohexadecanoic Acid
Formation of interchain carboxylic anhydrides on self-assembled monolayers with Fluoro N, N, N?, N?-tetra methyl foramidinium hexafluorophosphate. [2] This compound is used in self-assembly to produce hydrophilic SAMs. The resulting monolayers which are terminated with carboxylic acids can be further functionalized[3] with various amines and alcohols to introduce more complex end groups or multiple layers.[1]. Group: Biochemicals. Alternative Names: MHDA. Grades: Highly Purified. CAS No. 69839-68-5. Pack Sizes: 25mg, 50mg, 100mg, 250mg. Molecular Formula: HS(CH2)15CO2H, Molecular Weight: 288.49. US Biological Life Sciences.
Worldwide
2-Hydroxypentamethylene Sulfide (HPMS)
A novel-aldehyde-terminated self-assembled monlayer that can covalently bind amine-containing molecules from solution without using other reagents. Group: Biochemicals. Alternative Names: HPMS. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
CGP 3466B maleate
CGP 3466B maleate, a potent anti-apoptotic drug, is an orally active glyceraldehyde-3-phosphate dehydrogenase (GAPDH) inhibitor. CGP 3466B maleate was tested in clinical trials for its ability to help treat Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS) but the clinical trials have been terminated due to lack of benefit. Synonyms: N-(benzo[b][1]benzoxepin-5-ylmethyl)-N-methylprop-2-yn-1-amine;but-2-enedioic acid; Omigapil maleate; CGP 3466B; CGP-3466B; CGP3466B; TCH-346; TCH 346; TCH346; Omigapil maleate. Grades: >99 %. CAS No. 200189-97-5. Molecular formula: C23H21NO5. Mole weight: 391.42.
DAB-Am-32
DAB-Am-32. Group: Biochemicals. Alternative Names: 2-Propenenitrile, Dendrimer, 1,4-Butanediamine-core, Amino-terminated, 32-functional. Grades: Highly Purified. CAS No. 163611-04-9. Pack Sizes: 5mg. US Biological Life Sciences.
DAB-Am-64, Polypropylenimine tetrahexacontaamine Dendrimer, Generation 5.0. Group: Biochemicals. Alternative Names: 1,4-Butanediamine-core 2-Propenenitrile, dendrimer Amino-terminated 64-Functional. Grades: Highly Purified. CAS No. 163611-05-0. Pack Sizes: 2.5mg. US Biological Life Sciences.
Worldwide
Dexmecamylamine
Dexmecamylamine is a nicotinic channel modulator with antidepressant activity. It demonstrated positive effects in a number of animal models of depression and anxiety. It was active in the forced swim test in rats. It was also active in the behavioral despair test in mice. It was used in the treatment of major depression and was in clinical phase 3 trials, but now it was terminated. It was developed by Targacept. Uses: Dexmecamylamine was used in the treatment of major depression. Synonyms: TC-5214;TC5214;NIH-11008;NIH11008; TC 5214;NIH 11008;(1S,3S,4R)-N,2,2,3-tetramethylbicyclo[2.2.1]heptan-3-amine. Grades: >98%. CAS No. 107538-05-6. Molecular formula: C11H21N. Mole weight: 167.29.
Etamicastat HCl salt
Etamicastat HCl salt is a potent, peripherally selective, reversible, dopamine β-hydroxylase inhibitor (DBH inhibitor). It effectively decreases blood pressure, although does not prevent the development of hypertension in the spontaneously hypertensive rat. It was developed by Bial-Portela and was in clinic phase 2 trials, but now it is terminated. Uses: Etamicastat hcl salt effectively decreases blood pressure, although does not prevent the development of hypertension in the spontaneously hypertensive rat. Synonyms: BIA5-453 HCl salt; BIA-5-453 HCl salt;(R)-5-(2-aminoethyl)-1-(6,8-difluorochroman-3-yl)-1,3-dihydro-2H-imidazole-2-thione hydrochloride. Grades: 98%. CAS No. 677773-32-9. Molecular formula: C14H16ClF2N3OS. Mole weight: 347.81.
PAMAM Dendrimer Kit, generations 0-3
PAMAM Dendrimer Kit, generations 0-3 consists of a class of hyper-branched polymers with an ethylene diamine core, and amido amine as a branching structure that facilitates the formation of amineterminated full generation or carboxyl-terminated half generation dendrimers. It can be used in the functionalization of polymer with drugs, nucleic acids and imaging systems. Uses: They adopt nanometer-scale dimensions, and can be ideal candidates for drug delivery, gene transfection applications. Group: Dendrimers. Pack Sizes: unit weight includes solvent.
Tandem mass spectrometry (MS/MS) reveals that bis(3-aminopropyl)-PDMS mainly dissociates via intramolecular nucleophilic substitutions at the end groups. Uses: Bis(3-aminopropyl) terminated poly(dimethylsiloxane) may be used in the synthesis of dipicolylamidopropylpoly (dimethylsiloxane) (dppdms). Group: 3d printing materials bioelectronic materials self assembly and lithography. Alternative Names: PDMS. CAS No. 106214-84-0. Pack Sizes: 50 mL in poly bottle. Product ID: 3-[[[3-aminopropyl(dimethyl)silyl]oxy-dimethylsilyl]oxy-dimethylsilyl]propan-1-amine. Molecular formula: average Mn ~2500. Mole weight: H2N (CH2)3Si (CH3)2O[Si (CH3)2O]nSi (CH3)2 (CH2)3NH2. C[Si](C)=O.C[Si](C)(O)CCCN. InChI=1S/C12H34N2O2Si3/c1-17(2, 11-7-9-13)15-19(5, 6)16-18(3, 4)12-8-10-14/h7-14H2, 1-6H3. ZWRBLCDTKAWRHT-UHFFFAOYSA-N.
Ligand for Pd-catalyzed cross-coupling. Useful ligand for Pd-catalyzed carbon-nitrogen and carbon-oxygen bond forming procedures. Ligand for Ni-catalyzed amination of aryl chlorides. Ligand for Pd-catalyzed conversion of aryl halides to aryl nitriles. Ligand for Ni-catalyzed Suzuki reactions. Ni-catalyzed hydroamination of 1,3-dienes. Pd-catalyzed hydrocarbonation and hydroamination of 3,3-dihexylcyclopropene. Pd-catalyzed γ-arylation of β,γ-unsaturated ketones. Ligand for Ru-catalyzed reduction of nitriles to primary amines. Ligand for Rh-catalyzed alkyne head-to-tail dimerization. Ligand for Rh-catalyzed cross-coupling Ligand for Rh-catalyzed olefin isomerization Ligand for Ni or Rh-catalyzed borylation Ligand for regioselective Pd-catalyzed hydrophosphinylation of terminal alkynes to form branched alkenes. Group: Organic phosphine compounds. Alternative Names: 1,1'-Ferrocenediyl-bis(diphenylphosphine); DPPF. CAS No. 12150-46-8. Molecular formula: C34H28FeP2. Mole weight: 554.38. Appearance: Solid. Purity: 0.98. IUPACName: 1,1-Bis(diphenylphosphino)ferrocene. Catalog: ACM12150468-1.
Aluminum salen complexes as catalysts for the kinetic resolution of terminal epoxides via carbon dioxide coupling. Efficient synthesis of bio-renewable polyesters and cyclic carbonates through tandem catalysis. Catalyst used for the asymmetric hydrocyanation of nitroolefins. Catalyst used in the reaction of epoxides with heterocumulenes. Group: Heterocyclic organic compound. CAS No. 250611-13-3. Molecular formula: C36H52AlClN2O2. Mole weight: 607.26. Purity: 0.96. IUPACName: aluminum; 2, 4-ditert-butyl-6- [ [ [ (1R, 2R) -2- [ (3, 5-ditert-butyl-6-oxocyclohexa-2, 4-dien-1-ylidene) methylamino] cyclohexyl] amino] methylidene] cyclohexa-2, 4-dien-1-one; trichloride. Canonical SMILES: CC (C) (C)C1=CC (=CNC2CCCCC2NC=C3C=C (C=C (C3=O)C (C) (C)C)C (C) (C)C)C (=O)C (=C1)C (C) (C)C. [Al+3]. [Cl-]. [Cl-]. [Cl-]. ECNumber: 607-518-1. Catalog: ACM250611133.
2-(2-(2-Aminoethoxy)ethoxy)acetic acid
H2N-PEG2-CH2COOH belongs to a polyethylene glycol (PEG) linker covalently bound to E3 Ligase binding group (E3LB) and protein binding group (PB). H2N-PEG2-CH2COOH is a PEG derivative containing an amino group with a terminal carboxylic acid. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. PEG Linkers may be useful in the development of antibody drug conjugates and PROTACs. Synonyms: Amino-PEG2-CH2CO2H; Amino-PEG2-CH2COOH; Amino-PEG2-acetic acid. Grades: ≥95%. CAS No. 134978-97-5. Molecular formula: C6H13NO4. Mole weight: 163.17.
2',3'-Dideoxyadenosine 5'-Triphosphate
ddATP is an inhibitor of reverse transcriptases from retroviruses, such as HIV-1 and visna (Kis = 20 and 37 nM, respectively). ddATP is commonly used to terminate chain extension produced by the Taq polymerase for its competitive effect with dATP in cells. Uses: Ddatp is an inhibitor of reverse transcriptases from retroviruses. Synonyms: [[(2S,5R)-5-(6-aminopurin-9-yl)-2-oxolanyl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate; [[(2S,5R)-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate. Grades: ≥ 98 % by HPLC. CAS No. 24027-80-3. Molecular formula: C10H16N5O11P3. Mole weight: 475.18.
2,5-Dibromobenzoic Acid
2,5-Dibromobenzoic Acid is an intermediate used to prepare benzo[c]chromenone and benzo[c]chromene derivatives as estrogen β-receptor-selective agonists in comparison with effusol and estradiol. It is also used in the synthesis of aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 610-71-9. Pack Sizes: 1g, 5g. Molecular Formula: C7H4Br2O2, Molecular Weight: 279.91. US Biological Life Sciences.
2,6-Diamino-9-(3'-amino-2',3'-dideoxy-b-D-ribofuranosyl)purine is a purine nucleoside analog that has antiviral properties due to its ability to inhibit viral nucleic acid synthesis. It is particularly effective against herpes simplex virus and varicella-zoster virus, and has also shown potential in the treatment of HIV. Its mechanism of action involves incorporation into the replicating viral DNA, leading to chain termination and inhibition of viral replication. Synonyms: 9-(3-Amino-2,3-dideoxy-b-D-ribofuranosyl)-2,6-diaminopurine; 3'-Amino-2',3'-dideoxy-2,6-diaminopurine riboside. Molecular formula: C10H15N7O2. Mole weight: 265.28.
2-Amino-1,3-bis(carboxylethoxy)propane hydrochloride is a non-protein amino acid, sulfamic acid.2-Amino-1,3-bis(carboxylethoxy)propane hydrochloride contains one amino group and two terminal carboxylic acids.2-Amino-1,3-bis(carboxylethoxy)propane hydrochloride has a variety of physiological functions, including maintaining the stability of cell membranes, regulating cholesterol metabolism, supporting the normal function of the nervous system, participating in collagen synthesis, and anti-oxidation [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2421153-68-4. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-23212A.
2-Amino-2'-deoxy-N6,N6-dimethyl-2'-adenosine
2-Amino-2'-deoxy-N6,N6-dimethyl-2'-adenosine is an intriguing biomedical agent, conquering the realm of antiviral mastery and enveloping RNA pathogens within its strategic web. Through an artful act of termination, this compound disrupts viral replication. Such fortitude emanates from its prowess in inhibiting viral polymerase activity, thwarting the insidious dance of their replication and gallantly diminishing the burden of viral load. Synonyms: 6-Dma-dguo; 6-Dimethylamino-2'-deoxyguanosine; Adenosine, 2-amino-2'-deoxy-N,N-dimethyl-; 2'-Deoxy-6-dimethylaminoguanosine; 2-Amino-6-(dimethylamino)-9-(2-deoxy-beta-D-ribofuranosyl)-9H-purine; 9-(2-Deoxypentofuranosyl)-2-imino-N,N-dimethyl-2,9-dihydro-1H-purin-6-amine. Grades: ≥95%. CAS No. 83061-20-5. Molecular formula: C12H18N6O3. Mole weight: 294.31.
2-Amino-5-methylnicotinaldehyde
2-Amino-5-methylnicotinaldehyde is a reactant used in the preparation of naphthyridines by Cu-catalyzed hydroamination / Friedlander reaction with terminal alkynes. Group: Biochemicals. Grades: Highly Purified. CAS No. 1023814-35-8. Pack Sizes: 10mg, 25mg. Molecular Formula: C7H8N2O, Molecular Weight: 136.15. US Biological Life Sciences.
Worldwide
2-Amino-5-methylnicotinaldehyde
A reagent used in the preparation of naphthyridines by Cu-catalyzed hydroamination/Friedlander reaction with terminal alkynes. Synonyms: 2-amino-5-methylpyridine-3-carbaldehyde. CAS No. 1023814-35-8. Molecular formula: C7H8N2O. Mole weight: 136.15.
2-Amino-9-(3-deoxy-3-fluoro-beta-D-ribofuranosyl)-9H-purine is used in the biomedical industry as an antiviral drug, specifically to treat hepatitis B and C. It works by inhibiting the replication of the virus, preventing its spread and reducing the severity of the disease. Its mechanism of action involves incorporation into the viral DNA, leading to premature termination of viral replication. Synonyms: (2R,3S,4S,5R)-2-(2-Amino-9H-purin-9-yl)-4-fluoro-5-(hydroxymethyl)tetrahydrofuran-3-ol; 9-(3-Deoxy-3-fluoro-β-D-ribofuranosyl)-9H-purin-2-amine. Grades: ≥95%. CAS No. 1612192-04-7. Molecular formula: C10H12FN5O3. Mole weight: 269.23.
2'-Azido-2'-deoxyadenosine
2'-Azido-2'-deoxyadenosine is a nucleoside analog that has been found to be effective in treating viral infections. It is commonly used to inhibit the replication of retroviruses such as HIV and to prevent graft rejection following organ transplantation. This compound functions by terminating DNA synthesis and ultimately preventing the virus or transplant from replicating. Synonyms: 2-Azido-D-adenosine; 2'-Azido-2'-deoxy-D-adenosine; (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-azido-2-(hydroxymethyl)tetrahydrofuran-3-ol. Grades: ≥95%. CAS No. 58699-61-9. Molecular formula: C10H12N8O3. Mole weight: 292.25.
2-Chlorotrityl Chloride Resin
Amino acids can be attached to 2-Cl-Trt chloride resin with very little or no racemization. The steric bulk of 2-chlorotrityl chloride resin inhibits diketopiperazine formation, which can be a major side reaction in the synthesis of peptides with C-terminal proline. Uses: 2-chlorotrityl chloride resin can be cleaved under extremely mild acid conditions that leave boc/tbu based protecting groups in place. thus it is used to prepare protected peptide fragments. Group: Unsubstituted resins. Alternative Names: 2-Cl-Trt chloride resin. Pack Sizes: 25g, 100g.
2'-Deoxy-2'-fluoro-arabinoisocytidine
2'-Deoxy-2'-fluoro-arabinoisocytidine is a potent antiviral nucleoside analog used in the biomedical industry. It shows activity against certain RNA viruses. This compound has been extensively studied for its potential in the reserch of viral infections such as hepatitis C and HIV. Its mechanism of action involves incorporation into viral RNA, leading to premature termination of viral replication. Synonyms: 4-Amino-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)?-2(1H)?-pyrimidinone. CAS No. 1006872-82-7. Molecular formula: C9H12FN3O4. Mole weight: 245.21.
2'-Deoxy-a-guanosine
2'-Deoxy-a-guanosine is a nucleoside analog of pivotal significance, demonstrating profound antiviral attributes. This esteemed compound orchestrates a masterstroke by impeding viral DNA replication, thereby functioning as an indomitable chain terminator. Synonyms: 2-amino-9-[(2S,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5H-purin-6-one. Grades: ≥ 98% (HPLC). CAS No. 19916-78-0. Molecular formula: C10H13N5O4. Mole weight: 267.25.
2'-Deoxycytidine-3'-monophosphate
2'-Deoxycytidine-3'-monophosphate is a nucleotide analog and a precursor to the synthesis of DNA. It is commonly used in the pharmaceutical industry as an antiviral agent, particularly for treating diseases caused by DNA viruses such as herpes and varicella-zoster. Its mechanism of action involves inhibition of viral DNA synthesis by acting as a chain terminator during replication. Synonyms: Desoxy-CMP; Deoxy-ribo-cytidylic acid; (2R,3S,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-2-(hydroxymethyl)tetrahydrofuran-3-yl dihydrogen phosphate; 2-deoxycytidine 3-(dihydrogen phosphate); 2'-Deoxy-3'-cytidylic acid. Grades: ≥97% by HPLC. CAS No. 6220-63-9. Molecular formula: C9H14N3O7P. Mole weight: 307.20.
Exceptional ligands for Pd-catalyzed amination and amidation of aryl sulfonates. Ligand used for the Pd-catalyzed Suzuki-Miyaura coupling reaction and carbonyl enolate coupling. Ligand used for the chemoselective amination of aryl chlorides. Ligand used for the Pd-catalyzed borylation of aryl chlorides, for the formation of trifluoroborates. Ligand used for the Pd-catalyzed amination of vinyl halides and triflates. Ligand used for the Pd-catalyzed three-component synthesis of indoles. Ligand used for the Pt-catalyzed regioselective hydrosilylation of functionalized terminal arylalkynes. Ligand used for the Pd-catalyzed synthesis of carbazoles. Ligand used for the Pd-catalyzed Suzuki-Miyaura coupling of aryl chloride and NHC-boranes. Ligand used for the direct arylation of picoline N-oxide. Ligand used for the Negishi coupling of 2-heterocyclic organozinc reagents. Catalyst for a phosphine-catalyzed Heine reaction. Ligand used for the palladium-catalyzed oxidative coupling of indoles and heteroarenes. Ligand used for the silver-catalyzed hydrogenation of aldehydes. Ligand used for the palladium-catalyzed cyanation of heterycyclic halides. Group: Organic phosphine compounds. Alternative Names: Dicyclohexyl(2', 4', 6'-Triisopropylbiphenyl-2-Yl)Phosphine. CAS No. 564483-18-7. Molecular formula: C33H49P. Mole weight: 476.72. Appearance: Solid. Purity: 0.98. IUPACName: dicyclohexyl-[2-[2,4,
Ligand used in the Pd-catalyzed Suzuki coupling and animation of unactivated aryl chlorides. The reactions generally occur at room temperature and give high yields of product. Ligand used in Pd-catalyzed C-N bond formation. A general synthesis of N6-aryl-2'deoxyadenosine analogues. Ligand used in Pd-catalyzed N-arylation of indoles. Ligand used in Pd-catalyzed synthesis of aryl-tert-butyl ethers. Effective ligand in the Pd-catalyzed arylation of ester enolates. Ligand employed in arylation of ketone enolates using ortho-halo nitrobenezenes. Ligand employed in the amination of aryl nonaflates using Pd catalysts. Ligand used for cascade alkenyl amination/Heck reaction for the synthesis of indoles. Ligand used in Pd-catalyzed Kumada-Corriu cross coupling at low temperatures. Ligand used in Rh-catalyzed intramolecular hydroamination of unactivated terminal and internal alkenes with primary and secondary amines. Ligand used in Au-catalyzed cycloisomerization of allenes. Group: Organic phosphine compounds. Alternative Names: 2-di-cyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl; 118492-EP2272832A1; (2'-dicyclohexylphosphanyl-biphenyl-2-yl)dimethyl-amine; 2-(Dicyclohexylphosphino)-2'-(N,N-diMethylaMino)biphenyl, 98% DavePhos; (2'-dicyclohexylphosphanyl -biphenyl-2-yl)-dimethyl-amine; Buchwald phosphine ligands, davephos phosphine ligand-; 2-dicyclohexylphosphino-2'-(N,N'-dimethylamino)biphe
2-Methylmercaptoethanol
2-Methylmercaptoethanol is an intermediate used to prepare aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activities and minimal cross-kinase activities. It is also used to prepare methionine analogs as inhibitors of methionyl-tRNA synthetase with antimicrobial activities. Group: Biochemicals. Grades: Highly Purified. CAS No. 5271-38-5. Pack Sizes: 1g, 10g. Molecular Formula: C3H8OS, Molecular Weight: 92.16. US Biological Life Sciences.
Worldwide
2'-O-Methylguanosine-5'-triphosphate trilithium salt
2'-O-Methylguanosine-5'-triphosphate trilithium salt, a highly versatile compound, can be employed as an efficient probe for investigating RNA metabolism. It possesses the remarkable capability of obstructing RNA chain elongation, thus making it an invaluable research tool in the field. In addition to its chain terminating property, it also exhibits remarkable affinity with RNA-binding proteins and catalytic ribozymes, rendering it ideal for studying complex RNA-protein interactions and enzymatic activities. Synonyms: 2'-O-Me-GTP trilithium salt; Trilithium 5'-O-[ ({[ (hydroxyphosphinato) oxy]phosphinato}oxy) phosphinato]-2'-O-methylguanosine; Guanosine, 2'-O-methyl-, 5'-(tetrahydrogen triphosphate), lithium salt (1:3); lithium ((2R,3R,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3-hydroxy-4-methoxytetrahydrofuran-2-yl)methyl hydrogen triphosphate. Grades: ≥97% by HPLC. Molecular formula: C11H15Li3N5O14P3. Mole weight: 555.00.
2'-TFA-NH-2'-Deoxyuridine is a nucleoside analogue that has been used to treat certain viral infections and cancers. It is incorporated into the DNA of the target cells, causing chain termination and preventing further replication. Its antiviral activity has been observed against herpes simplex virus types 1 and 2, as well as varicella zoster virus. It has also shown promise in slowing the growth of certain tumors. Synonyms: 2'-TFA-NH-dU; 2'-trifluoroacetamido-2'-deoxyuridine; Uridine, 2'-deoxy-2'-[(trifluoroacetyl)amino]-; 2'-Deoxy-2'-[(trifluoroacetyl)amino]uridine; Uridine, 2'-deoxy-2'-[(2,2,2-trifluoroacetyl)amino]-; N-((2R,3R,4S,5R)-2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-3-yl)-2,2,2-trifluoroacetamide. Grades: ≥97% by HPLC. CAS No. 51989-21-0. Molecular formula: C11H12F3N3O6. Mole weight: 339.22.
An impurity of Dabigatran. Dabigatran is a very potent anticoagulant, showing that the terminal phenyl can be substituted by the more hydrophilic 2-pyridyl group without substantial loss of activity. Synonyms: Dabigatran Etexilate impurity H; N-[(1-Methyl-1H-benzimidazol-5-yl)carbonyl]-N-2-pyridinyl-β-alanine ethyl ester; Dabigatran Impurity S. Grades: ≥95%. CAS No. 1702936-92-2. Molecular formula: C19H20N4O3. Mole weight: 352.39.
3'-Amino-2',3'-dideoxyadenosine-5'-Triphosphate is a fascinating triphosphate derivative that piques the interest of biochemical researchers due to its investigative abilities in the intricate realm of DNA sequencing mechanisms. As an analog of ATP and a substrate for DNA polymerases during DNA synthesis, this compound is both versatile and intriguing. Significantly, it is known to cause termination of DNA synthesis, thereby holding potential for groundbreaking discoveries. Synonyms: 3'-Amino-ddATP. Grades: ≥90% by AX-HPLC. Molecular formula: C10H17N6O11P3. Mole weight: 490.20.
3'-Amino-2',3'-dideoxycytidine-5'-triphosphate lithium salt-100 mM aqueous solution
3'-Amino-2',3'-dideoxycytidine-5'-triphosphate lithium salt-100 mM aqueous solution is a crucial component in biomedical research. Primarily used as a substrate in DNA sequencing and polymerase chain reactions (PCR), it assists in the analysis of genetic material. Its incorporation into DNA can help determine nucleotide-specific chain termination and identify mutations linked to diseases such as viral infections and certain types of cancer. Synonyms: 3'-Amino-ddCTP.Li. Grades: 90%. Molecular formula: C9H17N4O12P3·xLi. Mole weight: 466.17 (free acid).
3'-Azido-3'-deoxy-5-fluoro-beta-L-cytidine
3'-Azido-3'-deoxy-5-fluoro-beta-L-cytidine is a nucleoside analogue that inhibits viral replication by terminating DNA synthesis. It is currently being used to treat hepatitis B and HIV infections. This drug works by being selectively incorporated into viral DNA, causing chain termination and preventing further synthesis. It has also shown promise in treating certain types of cancer by inhibiting cell proliferation and inducing apoptosis. Synonyms: 4-amino-1-[(2S,3S,4R,5R)-4-azido-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-fluoropyrimidin-2-one. Grades: ≥95%. CAS No. 2095417-76-6. Molecular formula: C9H11FN6O4. Mole weight: 286.22.
3-(Boc-amino)-3-methyl-1-butanol
3-(Boc-amino)-3-methyl-1-butanol is an intermediate used in the synthesis of (2E)-5-(tert-Butyloxycarbonylamino)-5-methylhex-2-enoic Acid (B809765), which is used in the preparation of C-terminal sulfonamide analogs of NN703 as growth hormone secretagogues. Group: Biochemicals. Grades: Highly Purified. CAS No. 167216-22-0. Pack Sizes: 50mg, 100mg. Molecular Formula: C10H21NO3, Molecular Weight: 203.28. US Biological Life Sciences.
Worldwide
3-Bromo-4-fluoro-benzoic Acid Ethyl Ester
3-Bromo-4-fluoro-benzoic Acid Ethyl Ester is used to prepare 2,3-diarylpyrrole inhibitors of parasite cGMP-dependent protein kinase as novel anticoccidial agents. It is also used to synthesize Aminopyrazole Inhibitors for c-Jun N-terminal Kinase 3 (JNK3) over p38. Group: Biochemicals. Grades: Highly Purified. CAS No. 23233-33-2. Pack Sizes: 1g, 5g. Molecular Formula: C9H8BrFO2, Molecular Weight: 247.06. US Biological Life Sciences.
PyAOP is a phosphonium salt used as a coupling reagent in Solid-phase peptide synthesis, without undergoing side reactions with the amino terminus. PyAOP is a derivative of HOAt. Synonyms: PyAOP; (7-AZABENZOTRIAZOL-1-YLOXY)TRIPYRROLIDINO-PHOSPHONIUM HEXAFLUOROPHOSPHATE; 7-AZABENZOTRIAZOL-1-YLOXY-TRIS-(PYRROLIDINO)PHOSPHONIUM HEXAFLUOROPHOSPHATE; (7-AZABENZOTRIAZOLE-1-YLOXY)TRIPYRROLIDINOPHOSPHONIUM HEXAFLUOROPHOSPHATE; PYAOP; ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate; (7-Azabenzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate; (T-4)?-[3-(hydroxy-κO)?-3H-1,?2,?3-triazolo[4,?5-b]?pyridinato]?tri-1-pyrrolidinyl-Phosphorus(1+)? hexafluorophosphate(?1-); tri-1-pyrrolidinyl(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)-Phosphonium hexafluorophosphate(1-). Grades: 98%. CAS No. 156311-83-0. Molecular formula: C17H27N7OP?PF6. Mole weight: 521.38.
3-((tert-Butoxycarbonyl)amino)-3-methylbutanoic Acid is an intermediate used in the synthesis of (2E)-5-(tert-Butyloxycarbonylamino)-5-methylhex-2-enoic Acid (B809765), which is used in the preparation of C-terminal sulfonamide analogs of NN703 as growth hormone secretagogues. Group: Biochemicals. Grades: Highly Purified. CAS No. 129765-95-3. Pack Sizes: 250mg, 1g. Molecular Formula: C10H19NO4, Molecular Weight: 217.26. US Biological Life Sciences.
Worldwide
4-Amino-3-benzyl-1H-pyrazolo[3,4-d]pyrimidine 1-β-D-Ribofuranosyl 5'-(3-Thio-triphosphate) Triethylamine Salt
Used in the synthesis of nucleotide analogues containing a phosphorothiolate moiety at the terminal position of the phospate chain. Molecular formula: C17H22N5O12P3S x(C6H15N). Mole weight: 613.37.
5-[3-(Trifluoroacetamido)-E-1-propenyl]-2'-deoxyuridine is a potent antiviral agent utilized in the treatment of viral infections caused by herpes simplex viruses (HSV-1, HSV-2), varicella-zoster virus (VZV), and Epstein-Barr virus (EBV). This compound inhibits viral DNA replication, reducing viral propagation and promoting host recovery. Its mechanism of action involves the incorporation into viral DNA, leading to chain termination. Synonyms: 5-TFA-aa-2'-deoxyuridine; TFA-aa-dU; 2'-Deoxy-5-[(1E)-3-[(trifluoroacetyl)amino]-1-propen-1-yl]uridine; (E)-2'-Deoxy-5-[3-[(trifluoroacetyl)amino]-1-propenyl]-uridine; 2'-Deoxy-5-[(1E)-3-[(trifluoroacetyl)amino]-1-propenyl]-uridine; TFA-AA-2'-deoxyuridine. Grades: ≥98% by HPLC. CAS No. 115794-55-3. Molecular formula: C14H16F3N3O6. Mole weight: 379.29.
5'-Amino-2',5'-dideoxyuridine
5'-Amino-2',5'-dideoxyuridine is an imperative nucleoside analogue of significant relevance in the biomedical sector is effectively harnessed for addressing the ubiquitous viral diseases encompassing herpes and HIV. Distinguished by its remarkable characteristic, this compound effectively obstructs the progression of viral DNA synthesis through its adeptness at terminating replication chains. Moreover, its commendable antiviral attributes render it a promising candidate in the realm of therapeutic agent advancement, effectively countering the virulent onslaught of diverse viral infections. Synonyms: Uridine, 5'-amino-2',5'-dideoxy-; NSC 175992; 1-[(2R,4S,5R)-5-(aminomethyl)-4-hydroxy-tetrahydrofuran-2-yl]pyrimidine-2,4-dione. Grades: ≥95%. CAS No. 35959-38-7. Molecular formula: C9H13N3O4. Mole weight: 227.22.
5-[N(6-(Trifluoroacetamido)hexyl)-3-(E)-acrylamido]-2'-deoxyuridine, known for its potent antiviral properties, has become a pivotal component in research of combatting viral infections induced by herpes simplex viruses (HSV). Functionally, it obtrudes viral DNA replication by inducing chain termination throughout the process of viral DNA research and development. Synonyms: 5-TFA-aha-2'-deoxyuridine; TFA-aha-dU; 2'-Deoxy-5-[3-oxo-3-[[6-[(trifluoroacetyl)amino]hexyl]amino]-1-propenyl]-uridine; 5-TFA-aha-dU; uridine, 2'-deoxy-5-[3-oxo-3-[[6-[(trifluoroacetyl)amino]hexyl]amino]-1-propenyl]-; (E)-3-(1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-N-(6-(2,2,2-trifluoroacetamido)hexyl)acrylamide. Grades: ≥98% by HPLC. CAS No. 252337-58-9. Molecular formula: C20H27F3N4O. Mole weight: 396.45.
6-aminohexanoate-oligomer exohydrolase
The enzyme is involved in degradation of nylon-6 oligomers. It degrades linear oligomers of 6-aminohexanoate with a degree of polymerization of 2-20 by exo-type cleavage, removing residues sequentially from the N-terminus. Activity decreases with the increase of the polymerization number of the oligomer. cf. EC 3.5.1.117, 6-aminohexanoate-oligomer endohydrolase and EC 3.5.2.12, 6-aminohexanoate-cyclic-dimer hydrolase. Group: Enzymes. Synonyms: 6-aminohexanoate-dimer hydrolase; nylB (gene name); 6-aminohexanoic acid oligomer hydrolase (ambiguous); N-(6-aminohexanoyl)-6-aminohexanoate amidohydrolase; nylon-6 hydrolase (ambiguous). Enzyme Commission Number: EC 3.5.1.46. CAS No. 75216-15-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4434; 6-aminohexanoate-oligomer exohydrolase; EC 3.5.1.46; 75216-15-8; 6-aminohexanoate-dimer hydrolase; nylB (gene name); 6-aminohexanoic acid oligomer hydrolase (ambiguous); N-(6-aminohexanoyl)-6-aminohexanoate amidohydrolase; nylon-6 hydrolase (ambiguous). Cat No: EXWM-4434.
6-Hydroxy Dopamine Hydrochloride
6-Hydroxydopamine is a selective catecholaminergic neurotoxin. Studies show that 6-Hydroxydopamine can be used to create an animal model of Parkinson's disease as it causes almost complete destruction of nigral dopaminergic neurons and their striatal terminals when injected into the substantia nigra of rats. 6-Hydroxydopamine induces apoptosis in PC12 cells. Group: Biochemicals. Alternative Names: 2, 4, 5-Trihydroxyphene thylamine Hydrochloride; 5-(2-Aminoethyl)-1,2,4-benzenetriol Hydrochloride; 6-Hydroxydopamine Hydrochloride; Oxidopamine Hydrochloride; Topamine Hydrochloride. Grades: Highly Purified. CAS No. 28094-15-7. Pack Sizes: 2.5mg. US Biological Life Sciences.