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One of the impurities of Dacomitinib. Dacomitinib, aslo known as PF-299 and PF-00299804 or PF299804, is an orally bioavailable, highly selective, second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) family of tyrosine kinases (ErbB family) with potential antineoplastic activity. Synonyms: 2-Pyrrolidinone, 1-[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-5-hydroxy-; Dacomitinib Impurity WYQJ. Grades: ≥95%. CAS No. 2190490-31-2. Molecular formula: C19H16ClFN4O3. Mole weight: 402.81.
An intermediate in the preparation of HIV-integrase inhibitors. Group: Biochemicals. Alternative Names: 2-(1-Amino-1-methylethyl)-N-[(4-fluorophenyl)methyl]-1,6-dihydro-5-hydroxy-1-methyl-6-oxo-. Grades: Highly Purified. CAS No. 518048-03-8. Pack Sizes: 10mg. US Biological Life Sciences.
An labeled intermediate in the preparation of labeled HIV-integrase inhibitors. Group: Biochemicals. Alternative Names: 2-(1-Amino-1-methylethyl)-N-[(4-fluorophenyl)methyl]-1,6-dihydro-5-hydroxy-1-(methyl-d3)-6-oxo-4-pyrimidinecarboxamide. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
An impurity of Rosuvastatin.Rosuvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. Synonyms: 3-Oxo Rosuvastatin SodiuM Salt;-7-[4-(4-Fluorophenyl)-6-(1-Methylethyl)-2-[Methyl(Methylsulfonyl)aMino]-5-pyriMidinyl]-5-hydroxy-3-oxo-. Grades: > 95%. CAS No. 1346606-28-7. Molecular formula: C22H25FN3O6S. Na. Mole weight: 501.51.
4-Fluorohydroxy bupropion
4-Fluorohydroxy bupropion. Group: Biochemicals. Alternative Names: 1-(4-Fluorophenyl)-2-[(2-hydroxy-1,1-dimethylethyl)amino]-1-propanone. Grades: Highly Purified. CAS No. 1076198-13-4. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C13H18FNO2. US Biological Life Sciences.
4-Hydroxyatorvastatin is a hydroxylated metabolite of Atorvastatin, a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia. Group: Biochemicals. Alternative Names: ( βR,δR)-2-(4-Fluorophenyl)- β , δ -dihydroxy-4-[[ (4-hydroxyphenyl) amino]carbonyl]-5- (1-methylethyl) -3-phenyl-1H-pyrrole-1-heptanoic Acid Calcium Salt; p-Hydroxyatorvastatin. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Afatinib impurity 25. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-((3-chloro-4-fluorophenyl)amino)-6-(2-hydroxy-5-oxopyrrolidin-1-yl)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazoline 1-oxide. Molecular Formula: C22H20ClFN4O5. Mole Weight: 474.87. Catalog: APB02299.
Afatinib Impurity AFT-8
An impurity of Afatinib, a medication used to treat non-small cell lung carcinoma (NSCLC). Synonyms: Afatinib Impurity QJJ; N-[4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)-3-hydroxybutenamide; Butanamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-3-hydroxy-. Grades: ≥95%. CAS No. 2323570-72-3. Molecular formula: C24H27ClFN5O4. Mole weight: 503.95.
AZ 10397767
AZ 10397767 is a potent CXCR2 antagonist (IC50 = 1 nM). It significantly reduced the numbers of infiltrating neutrophils into both in vitro and in vivo tumor models and slows growing tumors. It attenuates oxaliplatin-induced NF-κB activation and increases oxaliplatin cytotoxicity, thus potentiates oxaliplatin-induced apoptosis in AIPC cells. It may be potential for treating cystic fibrosis and chronic obstructive pulmonary disease. It is orally bioavailable. Synonyms: AZ-10397767; AZ 10397767; AZ10397767. 5-[[(3-Chloro-2-fluorophenyl)methyl]thio]-7-[[(1R)-2-hydroxy-1-methylethyl]amino]thiazolo[4,5-d]pyrimidin-2(3H)-one. Grades: ≥98% by HPLC. CAS No. 333742-63-5. Molecular formula: C15H14ClFN4O2S2. Mole weight: 400.88.
An intermediate in the preparation of HIV-integrase inhibitors. Group: Biochemicals. Alternative Names: N-[1-[4-[[[ (4-Fluorophenyl) methyl]amino]carbonyl]-1, 6-dihydro-5-hydroxy-1-methyl-6-oxo-2-pyrimidinyl]-1-methylethyl]-carbamic Acid Phenylmethyl Ester. Grades: Highly Purified. CAS No. 518048-02-7. Pack Sizes: 10mg. US Biological Life Sciences.
A labeled intermediate in the preparation of labeled HIV-integrase inhibitors. Group: Biochemicals. Alternative Names: N-[1-[4-[[[ (4-Fluorophenyl) methyl]amino]carbonyl]-1, 6-dihydro-5-hydroxy-1- (methyl-d3) -6-oxo-2-pyrimidinyl]-1-methylethyl]carbamic Acid Phenylmethyl Ester. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
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DPC-681
DPC-681, sulfonamide derivatives, is an extremely potent and selective inhibitor of HIV protease. IC90s: wild-type HIV-1=4-40 nM. Synonyms: DPC 681; DPC-681; DPC681; DPH 153893; DPH-153893; DPH153893; (2R)-N-(2-aminoacetyl)-2-[[(2S)-4-[(3-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-[(3-fluorophenyl)methyl]amino]-3,3-dimethylbutanamide284661-68-3AM021737N-((3-Fluorophenyl)methyl)glycyl-N-((1S,2R)-3-(((3-aminophenyl)sulfo. Grades: 99.89%. CAS No. 284661-68-3. Molecular formula: C35H48FN5O5S. Mole weight: 669.857.
Epacadostat
Epacadostat, also known as INCB024360 or INCB24360, is a potent and selective IDO1 inhibitor with IC50 of 71.8 nM±17.5 nM, with potential immunomodulating and antineoplastic activities. It has been shown to promote T and natural killer-cell growth, to increase IFN-γ production, and to reduce conversion to regulatory T (Treg)-like cells in a coculture system of human allogeneic lymphocytes with either dendritic cells or tumor cells. Synonyms: IDO inhibitor 1; 1,2,5-Oxadiazole-3-carboximidamide, 4-[[2-[(aminosulfonyl)amino]ethyl]amino]-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-, [C(Z)]-; [C(Z)]-4-[[2-[(Aminosulfonyl)amino]ethyl]amino]-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide; ICBN 24360; ICBN-24360; ICBN24360; INCB 024360; INCB024360; INCB-024360. Grades: ≥95%. CAS No. 1204669-58-8. Molecular formula: C11H13BrFN7O4S. Mole weight: 438.23.
Hydroxy vandetanib
Hydroxy vandetanib. Group: Biochemicals. Alternative Names: 4- [ [ [4- [ (4-Bromo-2-fluorophenyl) amino] -6-methoxy-7-quinazolinyl] oxy] methyl] -1-piperidinemethanol. Grades: Highly Purified. CAS No. 910298-61-2. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C22H24BrFN4O3. US Biological Life Sciences.
Worldwide
INCB024360
INCB024360. Group: Biochemicals. Alternative Names: (E)-4-amino-N-(3-Chloro-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide. Grades: Highly Purified. CAS No. 914471-09-3. Pack Sizes: 25mg. US Biological Life Sciences.
Worldwide
Lapatinib Hydroxylamine
a complex used in human metabolism of lapatinib which is a dual kinase inhibitor. Synonyms: N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[hydroxy[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine. Grades: > 95%. CAS No. 1360431-86-2. Molecular formula: C29H26ClFN4O5S. Mole weight: 597.07.
A Rosuvastatin. Group: Biochemicals. Alternative Names: 5- (Hydroxymethyl) -4- (4-fluorophenyl) -6-isopropyl-2-[methyl (methylsulfonyl) amino]pyrimidine. Grades: Highly Purified. CAS No. 147118-36-3. Pack Sizes: 100mg. US Biological Life Sciences.
Worldwide
O-Desmorpholinopropyl Gefitinib
A metabolite of Gefitinib. Group: Biochemicals. Alternative Names: 4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinol;4-(3-Chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline. Grades: Highly Purified. CAS No. 184475-71-6. Pack Sizes: 100mg. US Biological Life Sciences.
Worldwide
o-Hydroxy Atorvastatin, Dihydrate Monosodium Salt
A metabolite of Atorvastin, a selective, competitive HMG-CoA reductase inhibitor. Atorvastin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia. Group: Biochemicals. Alternative Names: ( βR,δR)-2-(4-Fluorophenyl)- β , δ -dihydroxy-4-[[ (2-hydroxyphenyl) amino]carbonyl]-5- (1-methylethyl) -3-phenyl-1H-pyrrole-1-heptanoic Acid Dihydrate Monosodium Salt;BMS 243887-01; PD 152873; o-Hydroxyatorvastatin Dihydrate Monosodium Salt. Grades: Highly Purified. CAS No. 1421760-64-4. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
p-Hydroxy Atorvastatin, Disodium Salt
A metabolite of Atorvastin, a selective, competitive HMG-CoA reductase inhibitor. Atorvastin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia. Group: Biochemicals. Alternative Names: ( βR,δR)-2-(4-Fluorophenyl)- β , δ -dihydroxy-4-[[ (4-hydroxyphenyl) amino]carbonyl]-5- (1-methylethyl) -3-phenyl-1H-pyrrole-1-heptanoic Acid Disodium Salt; BMS 241423-01; PD 142542; p-Hydroxyatorvastatin Disodium Salt. Grades: Highly Purified. CAS No. 1276537-18-8. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Raltegravir
Raltegravir is a potent integrase (IN) inhibitor, used to treat HIV infection. Group: Inhibitors. Alternative Names: Raltegravir; N-((4-Fluorophenyl)methyl)-1, 6-dihydro-5-hydroxy-1-methyl-2-(1-methyl-1-(((5-methyl-1, 3, 4-oxadiazol-2-yl)carbonyl)amino)ethyl)-6-oxo-4-pyrimidinecarboxamide; N-(2-(4-(4-Fluorobenzylcarbamoyl)-5-hydroxy-1-methyl-6-oxo-1, 6-dihydropyrimidin-2-yl)propan-2-yl)-5-methyl-1, 3, 4-oxadiazole-2-carboxamide; N-(2-(4-(4-Fluorobenzylcarbamoyl)-5-hydroxy-1-methyl-6-oxo-1, 6-dihydropyrimidin-2-yl)p; Raltegravir(R&D); Raltegravir(free base);N-(4-fluorobenzyl)-5-hydroxy-1-methyl-2-(2-(2-methyl-1,3,4-oxadiazole-5-carboxamido)propan-2-yl)-6-oxo-1,6-dihydropyrimidine-4-carboxamide;N-((4-Fluorophenyl)methyl)-1,6-dihydro-5-hydroxy-1-methyl-2-(1-methyl-1-(((5-methyl-1,3,4-oxadiazol-2-yl)carbonyl)am. CAS No. 518048-05-0. Molecular formula: C20H21FN6O5. Mole weight: 444.42. Appearance: Solid. Purity: 0.9953. Canonical SMILES: O=C (C (O)=C (C (NCC1=CC=C (C=C1)F)=O)N=C2C (C) (C)NC (C3=NN=C (C)O3)=O)N2C. Catalog: ACM518048050.
Raltegravir-d3 Potassium Salt
A potent human immunodeficiency virus (HIV) integrase inhibitor. A novel anti-AIDS drug. Group: Biochemicals. Alternative Names: N-[ (4-Fluorophenyl) methyl]-1, 6-dihydro-5-hydroxy-1-methyl-2-[1-methyl-1-[[ (5-methyl-1, 3, 4-oxadiazol-2-yl) carbonyl]amino]ethyl]-6-oxo-4-pyrimidinecarboxamide-d3 Potassium Salt. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Raltegravir Potassium Salt
A potent human immunodeficiency virus (HIV) integrase inhibitor. A novel anti-AIDS drug. Group: Biochemicals. Alternative Names: N-[ (4-Fluorophenyl) methyl]-1, 6-dihydro-5-hydroxy-1-methyl-2-[1-methyl-1-[[ (5-methyl-1, 3, 4-oxadiazol-2-yl) carbonyl]amino]ethyl]-6-oxo-4-pyrimidinecarboxamide Potassium Salt. Grades: Highly Purified. CAS No. 871038-72-1. Pack Sizes: 2.5mg. US Biological Life Sciences.
Worldwide
Rosuvastatin EP Impurity A
Rosuvastatin EP Impurity A is an impurity of Rosuvastatin, which is a statin medication used to prevent cardiovascular disease in those at high risk and treat abnormal lipids. Synonyms: (3R,5S,6E)-7-[2-(2,N-Dimethyl-2-hydroxypropane-1-sulfonamido)-4-(4-fluorophenyl)-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid; (3R,5S,6E)-7-[4-(4-Fluorophenyl)-2-[[(2-hydroxy-2-methylpropyl)sulfonyl](methyl)amino]-6-(1-methylethyl)-pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid; (3R,5S,E)-7-(4-(4-Fluorophenyl)-2-((2-hydroxy-N,2-dimethylpropyl)sulfonamido)-6-isopropylpyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid; S-Desmethyl-S-(2-hydroxy-2-methylpropyl) Rosuvastatin; 6-Heptenoic acid, 7-[4-(4-fluorophenyl)-2-[[(2-hydroxy-2-methylpropyl)sulfonyl]methylamino]-6-(1-methylethyl)-5-pyrimidinyl]-3,5-dihydroxy-, (3R,5S,6E)-; (3R,5S,6E)-7-[4-(4-Fluorophenyl)-2-[[(2-hydroxy-2-methylpropyl)sulfonyl]methylamino]-6-(1-methylethyl)-5-pyrimidinyl]-3,5-dihydroxy-6-heptenoic acid; Rosuvastatin Calcium EP Impurity A. Grades: ≥95%. CAS No. 1715120-13-0. Molecular formula: C25H34FN3O7S. Mole weight: 539.62.
Rosuvastatin EP Impurity C Sodium Salt
Rosuvastatin EP Impurity C Sodium Salt is an impurity of Rosuvastatin, which is a statin medication used to prevent cardiovascular disease in those at high risk and treat abnormal lipids. Synonyms: Rosuvastatin Impurity Sodium Salt; 5-Oxo Rosuvastatin Sodium Salt; Sodium (R,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3-hydroxy-5-oxohept-6-enoate; (3R, 6E)-7-[4- (4-Fluorophenyl)-6-isopropyl-2-[methyl (methylsulfonyl)amino]pyrimidin-5-yl]-3-hydroxy-5-oxo-6-heptenoic Acid Sodium Salt; 6-Heptenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3-hydroxy-5-oxo-, sodium salt (1:1), (3R,6E)-; (3R, 6E)-7-[4- (4-Fluorophenyl)-6-isopropyl-2-[methyl (methylsulfonyl)amino]pyrimidin-5-yl]-3-hydroxy-5-oxo-6-heptenoic acid sodium salt. Grades: ≥95%. CAS No. 1620823-61-1. Molecular formula: C22H25FN3NaO6S. Mole weight: 501.51.
(S)-Mosapride citrate
(S)-Mosapride citrate is an impurity of Mosapride. Mosapride is a 5-HT4 receptor agonist and 5-HT3 receptor antagonist. It is used as a gastroprokinetic agent. Synonyms: Benzamide, 4-amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]-2-morpholinyl]methyl]-, (S)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1); 4-Amino-5-chloro-2-ethoxy-N-{[(2S)-4-(4-fluorobenzyl)-2-morpholinyl]methyl}benzamide 2-hydroxy-1,2,3-propanetricarboxylate (1:1); (S)-4-amino-5-chloro-2-ethoxy-N-((4-(4-fluorobenzyl)morpholin-2-yl)methyl)benzamide citrate. Grades: ≥95%. CAS No. 156925-25-6. Molecular formula: C21H25ClFN3O3.C6H8O7. Mole weight: 614.02.
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