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| Product | Description | |
|---|---|---|
| Anandamide | Anandamide is an endocannabinoid. Anandamide modulates both neuronal and immune functions through two protein-coupled cannabinoid receptors ( CB1 and CB2 ). Anandamide can activate numerous other receptors like PPARS , TRPV1 , and GPR18/GPR55. Anandamide also has potential anti-fungal and anti-inflammatory activities. Anandamide can be used for the research of Alzheimers disease (AD) and ulcerative colitis [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. Alternative Names: AEA. CAS No. 94421-68-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-10863. |  |
| Anandamide | Anandamide is an endogenous cannabinoid and TRPV1 receptor agonist. Findings suggest that endocannabinoids such as anandamide may help cause runnerÂs high, the feeling of euphoria, reduced anxiety and lessened ability to feel pain associated with exercise. Group: Biochemicals. Grades: Highly Purified. CAS No. 94421-68-8. Pack Sizes: 10mg, 25mg. Molecular Formula: C22H37NO2. US Biological Life Sciences. |  Worldwide |
| Anandamide-d4 | Anandamide-d4 is the labeled analogue of Anandamide (A637220), an endogenous cannabinoid and TRPV1 receptor agonist. Findings suggest that endocannabinoids such as anandamide may help cause runnerÂs high, the feeling of euphoria, reduced anxiety and lessened ability to feel pain associated with exercise. Group: Biochemicals. Grades: Highly Purified. CAS No. 946524-40-9. Pack Sizes: 1mg, 10mg. Molecular Formula: C22H33D4NO2. US Biological Life Sciences. | Worldwide |
| Anandamide-d8 | Anandamide-d8 is a deuterated labeled Anandamide [1]. Anandamide is an endocannabinoid. Anandamide modulates both neuronal and immune functions through two protein-coupled cannabinoid receptors ( CB1 and CB2 ). Anandamide can activate numerous other receptors like PPARS , TRPV1 , and GPR18/GPR55. Anandamide also has potential anti-fungal and anti-inflammatory activities. Anandamide can be used for the research of Alzheimers disease (AD) and ulcerative colitis [2] [3] [4] [5] [6]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: AEA-d8. CAS No. 924894-98-4. Pack Sizes: 1 mg (2.81 mM * 1 mL in Methyl acetate). Product ID: HY-10863S. | |
| C16:0 Anandamide phosphate | C16:0 Anandamide phosphate. Group: Others. Purity: >99%. Mole weight: 401.46. Stability: 1 Year. Storage: -20°C. Avanti Polar Lipids; lipid products; bioactive lipids; fluorescent lipids; singnal transduction; cell pathways; C16:0 Anandamide phosphate; Palmitoyl ethanolamide phosphate (sodium salt). Cat No: FLBZ-088. |  |
| C17:0 anandamide phosphate | C17:0 anandamide phosphate. Group: Others. Purity: >99%. Mole weight: 415.48. Stability: 1 Year. Storage: -20°C. Avanti Polar Lipids; lipid products; bioactive lipids; fluorescent lipids; singnal transduction; cell pathways; C17:0 anandamide phosphate; Heptadecanoyl ethanolamide phosphate (sodium salt). Cat No: FLBZ-080. | |
| C17:1 Anandamide | Bioactive Lipids. Alternative Names: 10Z-heptadecenoylethanolamide; 17:1 Ethanolamide. CAS No. 1094209-17-2. Molecular formula: C19H37NO2. Mole weight: 311.5. Appearance: Powder. Purity: >99%. IUPACName: (Z)-N-(2-hydroxyethyl)heptadec-10-enamide. Canonical SMILES: CCCCCC/C=C\CCCCCCCCC(=O)NCCO. Density: 0.918±0.06 g/cm3(Predicted). Catalog: ACM1094209172. |  |
| C18:2 anandamide phosphate | C18:2 anandamide phosphate. Group: Others. Purity: >99%. Mole weight: 425.482. Stability: 3 Months. Storage: -20°C. Avanti Polar Lipids; lipid products; bioactive lipids; fluorescent lipids; singnal transduction; cell pathways; C18:2 anandamide phosphate; Linoleoyl ethanolamide phosphate (sodium salt). Cat No: FLBZ-075. | |
| C20:4 Anandamide phosphate | C20:4 Anandamide phosphate. Group: Others. Purity: >99%. Mole weight: 449.496. Stability: 3 Months. Storage: -20°C. Avanti Polar Lipids; lipid products; bioactive lipids; fluorescent lipids; singnal transduction; cell pathways; C20:4 Anandamide phosphate; Arachidonoyl ethanolamide phosphate (sodium salt). Cat No: FLBZ-066. | |
| (R)-Methanandamide | (R)-Methanandamide (AM-356), an analog of the endocannabinoid ligand Anandamide, is a potent CB1 agonist with a K i of 20 nM. (R)-Methanandamide also activates vanilloid (TRPV1) receptors [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AM-356. CAS No. 157182-49-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-101389. | |
| (±)-2-Methyl Arachidonoyl-2'-Fluoroethylamide | (±)-2-Methyl arachidonoyl-2'-fluoroethylamide (2-Methyl-2'-fluoro AEA) is an analog of anandamide (AEA) in which the alcohol of the ethanolamide group has been removed and replaced with a fluorine atom. An analog of arachidonylethanolamide that is a strong, selective CB1 cannabinoid receptor agonist. Synonyms: 2-methyl-2'-fluoro AEA; 2-Methyl-2'-fluoro Anandamide; O-689; (A+/-)-2-Methylarachidonoyl-2'-fluoroethylamide N-(2-fluoroethyl)-2-methylicosa-5,8,11,14-tetraenamide. Grades: ≥95%. CAS No. 166100-39-6. Molecular formula: C23H38FNO. Mole weight: 363.6. |  |
| A 425619 | A 425619 is a potent and selective TRPV1 antagonist (IC50 = 3-9 nM) that inhibits TRPV1 activation by anandamide and N-arachidonoyl-dopamine. A 425619 exhibits an inhibitory effect against inflammatory, postoperative and osteoarthritic in vivo pain models. Uses: Analgesic. Synonyms: A-425619; A 425619; A425619; N-5-Isoquinolinyl-N'-[[(4-(trifluoromethyl)phenyl]methyl]urea. Grades: ≥98% by HPLC. CAS No. 581809-67-8. Molecular formula: C18H14F3N3O. Mole weight: 345.32. | |
| AACOCF | AACOCF, an anlogue of arachidonic acid, is a slow-binding inhibitor of cytosolic (85 kDa) phospholipase A2. It also inhibits fatty acid amide hydrolase (FAAH, anandamide amidase) in vitro. Synonyms: 1,1,1-Trifluoro-6Z,9Z,12Z,15Z-heneicosateraen-2-one; Arachidonyl trifluoromethyl ketone; Arachidonyltrifluoromethane. CAS No. 149301-79-1. Molecular formula: C21H31F3O. Mole weight: 356.47. | |
| AEA-d11 | AEA-d11. Group: Others. Purity: >99%. Mole weight: 358.602. Stability: 3 Months. Storage: -20°C. Avanti Polar Lipids; lipid products; bioactive lipids; fluorescent lipids; singnal transduction; cell pathways; AEA-d11; C20:4 anandamide-d11. Cat No: FLBZ-098. | |
| AEA-[d11] | AEA-[d11] is the labelled analogue of AEA, which has a role as a neurotransmitter, a vasodilator agent and a human blood serum metabolite. Synonyms: C20:4 anandamide-d11; AEA-d11; (5Z, 8Z, 11Z, 14Z)-N-(2-Hydroxyethyl)(16, 16, 17, 17, 18, 18, 19, 19, 20, 20, 20-2H11)-5, 8, 11, 14-icosatetraenamide; 5,8,11,14-Eicosatetraenamide-16,16,17,17,18,18,19,19,20,20,20-d11, N-(2-hydroxyethyl)-, (5Z,8Z,11Z,14Z)-; Anandamide-d11; Arachidonylethanolamide-d11; N-Arachidonoylethanolamine-d11; N-Arachidonoyl-2-hydroxyethylamide-d11; Arachidonoyl-EA-d11; N-(2-Hydroxyethyl)anachidonamide-d11; 5,8,11,14-Eicosatetraenoylethanolamide-d11; Anandamide(20:4, n-6)-d11. Grades: >99%. CAS No. 2260669-86-9. Molecular formula: C22H26D11NO2. Mole weight: 358.60. | |
| AM 1172 | AM 1172, an AEA analogue, has been found to be an anandamide uptake inhibitor as well as a cannabinoid receptor partial agonist. Synonyms: AM 1172; AM1172; AM-1172; N-(5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraen-1-yl-4-hydroxybenzamide. Grades: ≥98% by HPLC. CAS No. 251908-92-6. Molecular formula: C27H39NO2. Mole weight: 409.60. | |
| AM404 | AM-404 is a selective inhibitor of the carrier-mediated transport of anandamide without affecting anandamide hydrolysis. AEM is also an analog of arachidonyl ethanolamide (AEA) which potentiates the activity of endogenous AEA by blocking its reuptake into presynaptic neurons. AM404 inhibits endocannabinoid cellular uptake, binds weakly to CB1 and CB2 cannabinoid receptors, and is formed by fatty acid amide hydrolase (FAAH) in vivo. Synonyms: 5,8,11,14-Eicosatetraenamide, N-(4-hydroxyphenyl)-, (5Z,8Z,11Z,14Z)-; (5Z,8Z,11Z,14Z)-N-(4-Hydroxyphenyl)-5,8,11,14-eicosatetraenamide; 5,8,11,14-Eicosatetraenamide, N-(4-hydroxyphenyl)-, (all-Z)-; AM 404; AM404. Grades: ≥98%. CAS No. 183718-77-6. Molecular formula: C26H37NO2. Mole weight: 395.58. | |
| Arachidonoyl-2'-fluoroethylamide | Arachidonoyl-2'-fluoroethylamide (2-fluoro AEA) is an analog of anandamide in which the alcohol of the ethanolamide group has been removed and replaced with a fluorine atom. Arachidonoyl 2'-fluoroethylamide is a CB1 receptor agonist with Ki of 26.7 nM for CB1 and Ki of 908 nM for CB2. The in vivo activity of 2-fluoro AEA is enhanced much less than the binding affinity, because the analog remains a good substrate for FAAH. Synonyms: 2'-fluoro AEA; 2'-fluoro Anandamide. Grades: ≥98%. CAS No. 166100-37-4. Molecular formula: C22H36FNO. Mole weight: 349.5. | |
| Arachidonoyl amide | Arachidonamide (AEA) is a weak cannabinoid CB1 and CB2 agonist. Arachidonamide was hydrolyzed by FAAH more effectively than AEA but exhibited significantly weaker binding to the human CB1 receptor with a Ki of 9.6 μM. AEA also inhibits rat glial gap junction cell-cell communication by 90% at a concentration of 20 μM. Arachidonamide are found to be the best substrates for anandamide amidohydrolase (AAH) with relative rates of hydrolysis about twice that of anandamide. Synonyms: Arachidonamide; Arachidonic acid amide; 5Z,8Z,11Z,14Z-eicosatetraenamide. Grades: ≥98%. CAS No. 85146-53-8. Molecular formula: C20H33NO. Mole weight: 303.5. | |
| Arachidonoyl-N-methyl amide | Anandamide (N-arachidonylethanolamine, AEA) is a brain lipid that binds to cannabinoid receptors with high affinity and mimics the psychoactive effects of plant-derived cannabiniod drugs, which is a fatty acid neurotransmitter derived from the non-oxidative metabolism of eicosatetraenoic acid (arachidonic acid), an essential omega-6 fatty acid. Anandamide inhibits the specific binding of [3H]-HU-243 to synaptosomal membranes with a Ki value of 52 nM. Arachidonoyl-N-methyl amide is an analog of anandamide that binds to the human central cannabinoid (CB1) receptor with a Ki of 60 nM. It inhibits rat glial gap junction cell-cell communication 100% at a concentration of 50 μM. Synonyms: (5Z,8Z,11Z,14Z)-N-methyl-5,8,11,14-Eicosatetraenamide; N-Methylarachidonamide; (all-Z)-N-methyl-5,8,11,14-Eicosatetraenamide. Grades: ≥98%. CAS No. 156910-29-1. Molecular formula: C21H35NO. Mole weight: 317.5. | |
| Arachidonoyl Serinol | Arachidonoyl Serinol, an endogenous cannabimimetic metabolite, is an inhibitor of monoacylglycerol lipase (MAGL). Arachidonoyl Serinol inhibits the hydrolysis of [ 3 H]2-oleoylglycerol and [ 3 H]anandamide with IC 50 s of ~70 μM [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 183718-70-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-121476. | |
| Arachidonyl serotonin | Arachidonyl serotonin is a dual target agent of transient receptor potential vanilloid-type I (TRPV1) antagonist and fatty acid amide hydrolase (FAAH) inhibitor, which is responsible for inactivation of anandamide and other endogenous cannabinoids. Its IC50 values are 37-40 nM and 5.6 μM for TRPV1 and FAAH respectively. It inhibits the FAAH activity isolated from mouse neuroblastoma cells with an IC50 value of 12 μM. It is a very tight binding, competitive inhibitor of FAAH. It does not inhibit cPLA2 and is essentially devoid of cannabimimetic activity. It was shown to be present in the ileum and jejunum of the gastrointestinal tract and modulate glucagon-like peptide-1 (GLP-1) secretion. It displays strong analgesic activity against both acute and chronic peripheral pain in rodents. Synonyms: AA-5HT; AA5HT; AA 5HT; N-arachidonoyl-serotonin; Arachidonoyl serotonin; N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-5Z,8Z,11Z,14Z-eicosatetraenamide; AA-5HT; AA5HT; N-arachidonoyl-serotonin; N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-5,8,11,14-eicosatetraenamide; (5Z,8Z,11Z,14Z)-N-(2-(5-hydroxy-1H-indol-3-yl)ethyl)icosa-5,8,11,14-tetraenamide. CAS No. 187947-37-1. Molecular formula: C30H42N2O2. Mole weight: 462.67. | |
| Arvanil | Arvanil is a vanilloid TRPV1 (VR1) and cannabinoid CB1 agonist with Ki values of 0.3 and 0.5 μM respectively. It increases lung tidal volume, diaphragm activity, mean arterial blood pressure and inhibits lymphocyte proliferation. It also inhibits the anandamide transporter. It has analgesic, vasodilatory and anti-inflammatory effects in vivo. It is a structural analog of capsaicin. It induces analgesia in rat and mouse models of pain. It is resistant to hydrolysis by FAAH. It is a potent inhibitor of anandamide accumulation. It inhibits growth of astrocytoma xenograft tumors in mice. It mimics the effect of neural precursor cells and has been shown to kill TRPV1-expressing tumor cells by secreting endovanilloids. Synonyms: RT-011322; B-6699; I14-44667; RT011322; B6699; I1444667; N-[(4-Hydroxy-3-methoxyphenyl)methyl]-5Z,8Z,11Z,14Z-eicosatetraenamide; (5Z,8Z,11Z,14Z)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-5,8,11,14-Eicosatetraenamide; N-Vanillylarachidonamide; (all-Z)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-5,8,11,14-eicosatetraenamide. Grades: ≥98% by HPLC. CAS No. 128007-31-8. Molecular formula: C28H41NO3. Mole weight: 439.64. | |
| BIA10-2474 | This active molecular is a reversible FAAH (fatty acid amide hydrolase) inhibitor that increases levels of the neurotransmitter anandamide in the central nervous system and in peripheral tissues (except the brain and spinal cord) under the development of Bial-Portela & Ca. SA. BIA 10-2474 can interact with the human endocannabinoid system and was inpplicated in the treatment of a range of different medical conditions including anxiety, Parkinson's disease, chronic pain of multiple sclerosis, cancer, hypertension and obesity. Clinical trial with BIA 10-2474 was on-going. However, severe adverse events occurred in January 2016 affecting 5 patients, including leading to the death of one. Uses: Neurological disorders; pain; psychiatric disorders. Synonyms: BIA 10-2474; BIA-10-2474; BIA10-2474; N-cyclohexyl-N-methyl-4-(1-oxidopyridin-1-ium-3-yl)imidazole-1-carboxamide;UNII-5AP1ZW859M; SCHEMBL427970; 5AP1ZW859M; GTPL9001; DOWVMJFBDGWVML-UHFFFAOYSA-N. Grades: 98%. CAS No. 1233855-46-3. Molecular formula: C16H20N4O2. Mole weight: 300.36. | |
| CAY10401 | Fatty acid amide hydrolase (FAAH) is the enzyme responsible for hydrolysis and inactivation of fatty acid amides including anandamide and oleamide. CAY10401 is a selective, potent inhibitor of rat FAAH exhibiting a Ki value of 0.14 nM. It is approximately 580-fold more potent than oleyl trifluoromethyl ketone. Synonyms: CAY 10401; CAY-10401; 1-oxazolo[4,5-b]pyridin-2-yl-9-octadecyn-1-one. Grades: ≥98%. CAS No. 288862-89-5. Molecular formula: C24H34N2O2. Mole weight: 382.5. | |
| CAY10412 | Anandamide (AEA), also known as N-arachidonoylethanolamine, is an endogenous lipid with cannabinergic activity. CAY10412 is an analog of AEA that has no intrinsic binding affinity for either CB1 or CB2 receptors. It is a potent inhibitor of AEA reuptake in U937 lymphoma cells with IC50 of 3 μM. It could be a useful tool for distinguishing the competing transporter theories. CAY10412 may enhance endocannabinoid signalling by augmenting endocannabinoid concentrations. Synonyms: CAY 10412; CAY-10412. Grades: ≥98%. CAS No. 390824-17-6. Molecular formula: C25H36O2S. Mole weight: 400.6. | |
| CAY10435 | Fatty acid amide hydrolase (FAAH) is the enzyme responsible for hydrolysis and inactivation of fatty acid amides including anandamide and oleamide. CAY10435 is a selective, potent inhibitor of rat FAAH with Ki value of 0.57 nM. It exhibited IC50 values of 0.81 nM, 83 nM, and 50 μM for FAAH, triacylglycerol hydrolase (TGH), and an uncharacterized hydrolase (KIAA1363), respectively. Synonyms: CAY 10435; CAY-10435. Grades: ≥98%. CAS No. 288862-73-7. Molecular formula: C18H26N2O2. Mole weight: 302.4. | |
| CAY10570 | Fatty acid amide hydrolase (FAAH) is the enzyme responsible for hydrolysis and inactivation of fatty acid amides including anandamide and oleamide. CAY10570 is a reversible competitive inhibitor of FAAH activity exhibiting an IC50 value of 1.3 μM. It has no affinity for the human CB1 receptor and acts as a competitive inhibitor of FAAH activity without being hydrolyzed. Synonyms: CAY 10570; CAY-10570. Grades: >98%. CAS No. 875014-22-5. Molecular formula: C25H32N2OS. Mole weight: 408.6. | |
| CB-25 | Δ9-Tetrahydrocannabinol (THC) is the primary psychoactive constituent of cannabis and an active cannabinoid pharmacotherapy component. Anandamide (AEA), also known as N-arachidonoylethanolamine, is an endogenous lipid with cannabinergic activity. CB-25 is a stable analog of Δ9-tetrahydrocannabinol (THC) and anandamide (AEA). It exhibits high affinity for the central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors with Ki values of 5.2 and 13 nM, respectively. Synonyms: CB25; CB 25. Grades: ≥98%. CAS No. 869376-63-6. Molecular formula: C25H41NO3. Mole weight: 403.6. | |
| CB-52 | Δ9-Tetrahydrocannabinol (THC) is the primary psychoactive constituent of cannabis and an active cannabinoid pharmacotherapy component. Anandamide (AEA), also known as N-arachidonoylethanolamine, is an endogenous lipid with cannabinergic activity. CB-52 is a stable analog of Δ9-tetrahydrocannabinol (THC) and anandamide (AEA). It exhibits high affinity for the central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors with Ki values of 210 and 30 nM, respectively. Synonyms: CB52;CB 52. Grades: ≥98%. CAS No. 869376-90-9. Molecular formula: C26H43NO3. Mole weight: 417.6. | |
| CB-86 | Cannabinoid receptors (CB) are of a class of cell membrane receptors in the G protein-coupled receptor superfamily. CB-86 is a resorcinol-anandamide hybrid compound that acts as a partial agonist for the CB1 receptor with Ki of 5.6 nM and a neutral antagonist for CB2 receptor with Ki of 7.9 nM. CB-86 exhibits antinociceptive effects in mice treated with formalin. Synonyms: CB86; CB 86. Grades: ≥98%. CAS No. 1150586-64-3. Molecular formula: C26H43NO3. Mole weight: 417.6. | |
| Dihomo-γ-linolenoyl ethanolamide | Dihomo-γ-linolenoyl ethanolamide is an endocannabinoid containing dihomo-γ-linoleate in place of the arachidonate moiety of AEA. Dihomo-γ-linolenoyl ethanolamide binds to recombinant human CB1 and CB2 receptors. Its specific role and relative importance as a cannabinergic neurotransmitter has not been elucidated. Synonyms: HGLEA; Homo-gamma-linolenylethanolamide; Anandamide (20.3,n-6); N-homo-gamma-linolenoylethanolamine. Grades: ≥98%. CAS No. 150314-34-4. Molecular formula: C22H39NO2. Mole weight: 349.6. | |
| Docosahexaenoyl Ethanolamide | Docosahexaenoyl ethanolamide (DHEA) is the ethanolamine amide of DHA that has been detected in both brain and retina. DHEA binds to the rat brain CB1 receptor with a Ki of 324 nM, which is approximately 10-fold higher than the Ki for AEA. It also inhibits shaker-related voltage-gated potassium channels in brain slightly better than AEA, with an IC50 of 1.5 μM. Synonyms: C22:6 anandamide; DHEA; Synaptamide; N-(2-hydroxyethyl)-4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenamide. Grades: >99%. CAS No. 162758-94-3. Molecular formula: C24H37NO2. Mole weight: 371.57. | |
| Docosatetraenoyl Ethanolamide | Docosatetraenoyl ethanolamide (DEA) is a potent endocannabinoid and anandamide analog containing docosatetraenoic acid in place of the arachidonate moiety of AEA. DEA acts on CB1 receptors in microglia and binds to rat synaptosomal membranes (Ki = 34.4 nM). Synonyms: DEA; N-(2-hydroxyethyl)-7Z,10Z,13Z,16Z-docosatetraenamide; 7,10,13,16-Docosatetraenylethanolamide; Adrenoyl-EA. Grades: ≥98%. CAS No. 150314-35-5. Molecular formula: C24H41NO2. Mole weight: 375.6. | |
| FAAH Inhibitor III, URB937 (Cyclohexylcarbamic acid-(3-carbamoyl-6-hydroxybiphenyl-3-yl)ester, Fatty Acid Amide Hydrolase Inhibitor III, URB937, Cyclohexylcarbamic acid-carbamoyl hydroxybiphenyl-3-yl) ester) | A blood-brain-barrier impermeable p-hydroxyphenylcarbamate compound that acts as a potent and irreversible inhibitor of FAAH activity (IC50 = 26.8nM rat brain) with excellent selectivity over monoacylglycerol lipases (IC50 > 100uM). Shown to rapidly block mouse liver FAAH activity over brain (ED50 = 0.2mg/kg vs. 40mg/kg, s.c.), elevate anandamide and palmitoylethanolamide levels in peripheral tissues (1mg/kg, i.p.) and exert antinociceptive action. The CNS-penetrant FAAH Inhibitor II, URB597 is also available. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| fatty acid amide hydrolase | Integral membrane protein, the enzyme is responsible for the catabolism of neuromodulatory fatty acid amides, including anandamide and oleamide, occurs in mammalia. Group: Enzymes. Synonyms: FAAH; oleamide hydrolase; anandamide amidohydrolase. Enzyme Commission Number: EC 3.5.1.99. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4491; fatty acid amide hydrolase; EC 3.5.1.99; FAAH; oleamide hydrolase; anandamide amidohydrolase. Cat No: EXWM-4491. | |
| IDFP | IDFP is an organophosphorus compound that acts as an irreversible inhibitor of MAGL and FAAH with IC50 values of 0.8 and 3 nM, respectively. Inhibition of MAGL and FAAH increases anandamide and 2-AG in the brain, resulting in increased cannabinoid signaling and typical cannabinoid behavioral effects in animal studies. Synonyms: Isopropyl Dodecylfluorophosphonate; 1-[fluoro(propan-2-yloxy)phosphoryl]dodecane. Grades: ≥98%. CAS No. 615250-02-7. Molecular formula: C15H32FO2P. Mole weight: 294.4. | |
| JNJ-40355003 | JNJ-40355003 is a selective fatty acid amide hydrolase (FAAH) inhibitor. JNJ-40355003 can elevate the plasma levels of anandamide, oleoyl ethanolamide, and palmitoyl ethanolamide in animal model. Synonyms: JNJ-40355003; JNJ 40355003; JNJ40355003; 4-((3-(4-chlorophenoxy)phenyl)methyl)-N-3-pyridinyl-1-Piperazinecarboxamide. Grades: 98%. CAS No. 1394894-41-7. Molecular formula: C23H23ClN4O2. Mole weight: 422.91. | |
| JZL195 | JZL195 is a potent dual inhibitor of Monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH), enzymes that degrade the endocannabinoids 2-arachidonoylglycerol (2-AG) and anandamide (AEA), the endogenous ligands for the cannabinoid G-protein coupled receptors CB1 and CB2. IC50 values are 2 nM for MAGL and 4 nM for FAAH. JZL195 has been shown to inhibit endocannabinoid hydrolysis and elevate 2-AG and AEA levels in vivo. Synonyms: JZL195; JZL-195; JZL 195. Grades: >98%. CAS No. 1210004-12-8. Molecular formula: C24H23N3O5. Mole weight: 433.46. | |
| KML-29 | KML-29 is an extremely specific monoacylglycerol lipase (MAGL) inhibitor. KML-2 should be useful to distinguish between actions of 2-arachidonoyl glycerol (an endogenous ligand of cannabinoid receptors that is deactivated by MAGL) and anandamide, another endocannabinoid. Group: Biochemicals. Alternative Names: 4-[Bis(1,3-benzodioxol-5-yl)hydroxymethyl]-1-piperidinecarboxylic Acid 2,2,2-Trifluoro-1-(trifluoromethyl)ethyl Ester; 1,1,1,3,3,3-Hexafluoropropan-2-yl 4- (Bis (benzo[d][1, 3]dioxol-5-yl) (hydroxy) methyl) piperidine-1-carboxylate; KML29. Grades: Highly Purified. CAS No. 1380424-42-9. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Linoleoyl ethanolamide | Linoleoyl ethanolamide (Linoleic acid monoethanolamide) is classified as a fatty acid ethanolamide. Linoleoyl ethanolamide only weakly binds G-protein-coupled cannabinoid receptors of type-1 (CB1) and CB2 receptors, and inhibits the binding of [3H] CP-55,940 with K i s of 10 and 25 μM, respectively. Linoleoyl ethanolamide is 4-fold less potent than anandamide at causing catalepsy in mice and it does not prolong sleep time [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Linoleic acid monoethanolamide. CAS No. 68171-52-8. Pack Sizes: 5 mg. Product ID: HY-113421. | |
| LY2183240 | LY2183240 is a novel and highly potent blocker of anandamide uptake. It inhibits fatty acid amide hydrolase (FAAH) activity. It increases brain anandamide concentration and exerts antinociceptive effects in formalin model of pain. Synonyms: LY2183240; LY-2183240; LY 2183240. Grades: >98%. CAS No. 874902-19-9. Molecular formula: C17H17N5O. Mole weight: 307.35. | |
| LY2183240 2'-isomer | LY2183240 2'-isomer is a 2,5-regioisomer of LY2183240 that inhibits anandamide hydrolysis and cellular reuptake. LY2183240 2'-isomer exhibits less potent activity than LY2183240. Synonyms: 5-([1,1'-Biphenyl]-4-ylmethyl)-N,N-dimethyl-2H-tetrazole-2-carboxamide; 5-((biphenyl-4-yl)methyl)-N,N-dimethyl-2H-tetrazole-2-carboxamide. Grades: ≥98%. CAS No. 1010096-65-7. Molecular formula: C17H17N5O. Mole weight: 307.4. | |
| MAFP | MAFP (Methyl Arachidonyl Fluorophosphonate) is an selective, active-site directed and irreversible inhibitor of cPLA2 and iPLA2. MAFP is also a potent irreversible inhibitor of anandamide amidase. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Methyl Arachidonyl Fluorophosphonate. CAS No. 188404-10-6. Pack Sizes: 1 mg (26.99 mM * 100 μL in Methyl acetate). Product ID: HY-103334. | |
| MM-22 | MM-22 is a biotinylated anandamide analog. It can block anandamide uptake with IC50 value of 0.5 μM in HaCaT cells. Synonyms: MM-22; MM 22; MM22; (3aS,4S,6aR)-Hexahydro-2-oxo-N-[2-[2-[2-[[(5Z,8Z,11Z,14Z)-1-oxo-5,8,11,14-eicosatetraen-1-yl]amino]ethoxy]ethoxy]ethyl]-1H-thieno[3,4-d]imidazole-4-pentanamide. Grades: ≥98% by HPLC. CAS No. 956605-71-3. Molecular formula: C36H60N4O5S. Mole weight: 660.95. | |
| N-acetylphosphatidylethanolamine-hydrolysing phospholipase D | This enzyme is involved in the biosynthesis of anandamide. It does not hydrolyse phosphatidylcholine and phosphatidylethanolamine. No transphosphatidation. The enzyme contains Zn2+ and is activated by Mg2+ or Ca2+. Group: Enzymes. Synonyms: NAPE-PLD; anandamide-generating phospholipase D; N-acyl phosphatidylethanolamine phospholipase D; NAPE-hydrolyzing phospholipase D. Enzyme Commission Number: EC 3.1.4.54. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3737; N-acetylphosphatidylethanolamine-hydrolysing phospholipase D; EC 3.1.4.54; NAPE-PLD; anandamide-generating phospholipase D; N-acyl phosphatidylethanolamine phospholipase D; NAPE-hydrolyzing phospholipase D. Cat No: EXWM-3737. | |
| N-Arachidonyl-GABA | N-Arachidonoyl-GABA is one member of a new class of lipoamino acids related to anandamide identified in bovine brain. N-Arachidonoyl-GABA displays analgesic activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 128201-89-8. Pack Sizes: 1 mg (64.17 mM * 40 μL in Ethanol); 5 mg (64.17 mM * 200 μL in Ethanol). Product ID: HY-103507. | |
| N-Arachidonylglycine | N-Arachidonylglycine has been isolated from cell cultures treated with arachidonoyl ethanolamide. It is a GPR18 agonist with EC50 value of 44.5 nM. It is a kind of endogenous anandamide-like compound. It is also an endogenous GlyT2 inhibitor and acts as a glycine transporter inhibitor. It has also been synthesized as an analog of AEA for structure/activity testing. It may be produced endogenously via oxidation of AEA, or by transacylation of arachidonoyl CoA. It has analgesic activities in whole animal experiments. Synonyms: N-[1-oxo-5Z,8Z,11Z,14Z-eicosatetraenyl]-glycine; Arachidonyl Glycine; (all-Z)-N-(1-Oxo-5,8,11,14-eicosatetraenyl)glycine; N-[(5Z,8Z,11Z,14Z)-1-oxo-5,8,11,14-eicosatetraenyl]glycine. Grades: ≥98% by HPLC. CAS No. 179113-91-8. Molecular formula: C22H35NO3. Mole weight: 361.52. | |
| N-Arachidonylglycine | N-Arachidonylglycine (NA-Gly), a carboxylic analog of the endocannabinoid anandamide (AEA), is a GPR18 agonist ( EC 50 = 44.5 nM). Unlike AEA, N-Arachidonylglycine has no activity at either CB1 or CB2 receptors. N-Arachidonylglycine inhibits GLYT2 ( IC 50 = 5.1 μM). N-Arachidonylglycine also is an effective activator of endometrial cell migration [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: NA-Gly. CAS No. 179113-91-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103332. | |
| N-Arachidonylglycine-d8 | N-Arachidonylglycine-d8 is a deuterated labeled N-Arachidonylglycine [1]. N-Arachidonylglycine (NA-Gly), a carboxylic analog of the endocannabinoid anandamide (AEA), is a GPR18 agonist ( EC 50 = 44.5 nM). Unlike AEA, N-Arachidonylglycine has no activity at either CB1 or CB2 receptors. N-Arachidonylglycine inhibits GLYT2 ( IC 50 = 5.1 μM). N-Arachidonylglycine also is an effective activator of endometrial cell migration [2] [3]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: NA-Gly-d8. CAS No. 1159908-44-7. Pack Sizes: 1 mg (2.71 mM * 1 mL in Ethanol). Product ID: HY-103332S. | |
| O-1918 | O-1918 is a cannabidiol analog and a selective, silent antagonist of a putative endothelial anandamide receptor distinct from CB1 or CB2 receptors. It is also an inhibitor of GPR18. It does not bind to CB1 or CB2 receptors at concentrations up to 30 μM. It inhibits endothelium-dependent vasodilation and cell migration induced by abnormal-cannabidiol in vitro and in whole animals. It also blocks the abnormal cannabidiol-induced activation of the phosphatidylinositol 3-kinase/Akt pathway in human umbilical vein endothelial cells. Synonyms: O-1918; O 1918; O1918; 1,3-Dimethoxy-5-methyl-2-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]benzene. Grades: ≥97% by HPLC. CAS No. 536697-79-7. Molecular formula: C19H26O2. Mole weight: 286.41. | |
| O-2093 | O-2093 is an inhibitor of anandamide uptake with IC50 of 17.3 μM. It shows little or no activity at CB1, CB2, TRPV1 and FAAH. Its intravenous administration inhibits limb spasticity in mice with chronic relapsing experimental allergic encephalomyelitis. Synonyms: O-2093; O 2093; O2093; N-(bis-3-chloro-4-hydroxybenzyl)-5Z,8Z,11Z,14Z-eicosatetraenamide; (5Z,8Z,11Z,14Z)-N,N-Bis[(3-chloro-4-hydroxyphenyl)methyl]-5,8,11,14-eicosatetraenamide. CAS No. 439080-01-0. Molecular formula: C34H43Cl2NO3. Mole weight: 584.62. | |
| O-Arachidonoyl ethanolamine hydrochloride | O-Arachidonoyl ethanolamine hydrochloride (O-AEA) is an AEA derivative that acts as a partial antagonist of CB1 receptor and a full agonist of CB2 receptor. O-AEA produced hypothermia in the mouse and acted as an antagonist in the presence of anandamide both in vivo and in vitro. Synonyms: O-AEA hydrochloride; Arachidonic acid-(2-aminoethyl)-ester hydrochloride; Virodhamine hydrochloride; 2-aminoethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate hydrochloride. Grades: ≥98%. CAS No. 443129-35-9. Molecular formula: C22H37NO2·HCl. Mole weight: 384. | |
| OL135 | OL135 is a CNS penetrant, highly potent and selective reversible inhibitor of FAAH. It exhibits analgesic pharmacology in various animal models without the motor impairment associated with direct CB1 agonism. It increases the analgesic and hypothermic activity of anandamide. Uses: Ol135 is used as an analgesic drug. Synonyms: OL-135;1-Oxo-1-[5-(2-pyridyl)oxazol-2-yl]-7-phenylheptane;7-Phenyl-1-[5-(2-pyridinyl)-2-oxazolyl]-1-heptanone;7-Phenyl-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]heptan-1-one. Grades: 98%. CAS No. 681135-77-3. Molecular formula: C21H22N2O2. Mole weight: 334.42. | |
| OMDM-2 | OMDM-2 is a selective inhibitor of anandamide cellular uptake. It can inhibit the cellular uptake of tritiated AEA with IC50 value of 3 μM. Synonyms: (9Z)-N-[1-((R)-4-Hydroxbenzyl)-2-hydroxyethyl]-9-octadecenamide. Grades: ≥99% by HPLC. CAS No. 616884-63-0. Molecular formula: C27H45NO3. Mole weight: 431.66. | |
| Oxy-arachidonoyl ethanolamide | Oxy-arachidonoyl ethanolamide is an analog of Δ9-THC, the psychotropic component of marijuana. It has high affinity for the peripheral cannabinoid (CB2) receptor with Ki values of 0.47 and 0.081 μM for hCB1 and hCB2, respectively. Synonyms: oxy-AEA; oxy-Anandamide; N-arachidonoyl-O-(2-hydroxyethyl)hydroxylamine; (5Z,8Z,11Z,14Z)-N-(2-hydroxyethoxy)icosa-5,8,11,14-tetraenamide. Grades: ≥98%. CAS No. 883296-70-6. Molecular formula: C22H37NO3. Mole weight: 363.5. | |
| Palmitoylisopropylamide | Palmitoyl-N-isopropylamide, a synthetic analog of palmitoyl ethanolamide, is an inhibitor of the FAAH (fatty acid amide hydrolase); pIC50 = 4.89 for inhibition of [3H]-anandamide metabolism. It displays little binding to CB1 and CB2 receptors (IC50 > 100 μM) and very weakly blocks anandamide uptake (IC50 ~ 100 μM). Synonyms: N-(1-Methylethyl)-hexadecanamide; PIA. CAS No. 189939-61-5. Molecular formula: C19H39NO. Mole weight: 297.52. | |
| Synaptamide | Synaptamide (Dehydroepiandrosteron; DHEA) is an endogenous metabolite and structural analogue of Anandamide. Synaptamide binds to both the cannabinoid-1 and 2 (CB1 and CB2) cannabinoid receptors and has anti-inflammatory properties. Synaptamide is the first small-molecule endogenous ligand of an adhesion G protein-coupled receptor (aGPCR) [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: N-Docosahexaenoyl ethanolamine (DHEA); Docosahexaenoyl ethanolamide. CAS No. 162758-94-3. Pack Sizes: 5 mg (67 mM * 200 μL in Ethanol); 10 mg (67 mM * 400 μL in Ethanol). Product ID: HY-100197. | |
| UCM 707 | UCM 707 is a potent endocannabinoid transport inhibitor (IC50 = 0.8 and 30 μM for inhibition of the anandamide transporter and FAAH, respectively). UCM 707 potentiates hypokinetic and antinociceptive effects of anandamide in vivo. Synonyms: UCM 707; UCM707; UCM-707; (5Z,8Z,11Z,14Z)-N-(3-Furanylmethyl)-5,8,11,14-eicosatetraenamide; N-(furan-3-ylmethyl)icosa-5,8,11,14-tetraenamide. CAS No. 390824-20-1. Molecular formula: C25H37NO2. Mole weight: 383.57. | |
| VDM 11 | VDM 11 is a potent and selective inhibitor of the anandamide membrane transporter (AMT) (IC50 = 4-11 μM), blocking cellular reuptake of anandamide and leads to inactivation of the endocannabinoid signal. VDM 11 also displays negligible agonist activity at the hVR1 receptor and weak action at CB1 and CB2 receptors. Synonyms: VDM 11; VDM11; VDM-11; (5Z,8Z,11Z,14Z)-N-(4-Hydroxy-2-methylphenyl)-5,8,11,14-eicosatetraenamide; N-(4-Hydroxy-2-methylphenyl)arachidonylamide. Grades: ≥98% by HPLC. CAS No. 313998-81-1. Molecular formula: C27H39NO2. Mole weight: 409.61. | |
| ZCZ011 | ZCZ011 is a potent and brain penetrant cannabinoid 1 (CB1) receptor positive allosteric modulator. ZCZ011 potentiates binding of CP55,940 to the CB1 receptor, enhances anandamide (AEA)-stimulated GTPγS binding in mouse brain membranes. ZCZ011 increases β-arrestin recruitment and ERK phosphorylation in hCB1 cells. ZCZ011 can be used for researching neuropathic and inflammatory pain [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1998197-39-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-118140. | |
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