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Apoptosis Activator 2. Group: Biochemicals. Grades: Purified. CAS No. 79183-19-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
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Apoptosis Activator 2
Apoptosis activator 2 is a cell-permeable apoptosis activator that promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. It increases procaspase-9 processing and subsequent caspase-3 activation. It induces apoptosis in tumor cells (IC50 = 4 - 9 μM for leukemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC50 > 40 μM). Synonyms: Apoptosis Activator 2; AAII; N-(3,4-dichlorobenzyl) Isatin. MDK83190; MDK-83190; MDK 83190. CAS No. 79183-19-0. Molecular formula: C15H9Cl2NO2. Mole weight: 306.142.
Apoptosis Compound Library
A unique collection of 1796 apoptosis-related compounds for apoptosis research, research in tumorigenesis, and anti-cancer drug screening; - Targets include Bcl-2, Caspase, p53, TNF-alpha, and surviving, etc. ; - Bioactivity and safety confirmed by pre-clinical research and clinical trials, and some of them are approved by FDA; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L9000. Categories: Apoptosis Compounds Libraries.
Apoptosis Inducing siRNA (5 nmol)
Apoptosis Inducing siRNA. Small interfering RNA (siRNA) is 21-25 bp in length, double-stranded small RNA molecules regulating gene expression by degrading mRNA after transcription and preventing translation. Uses: Transfection of DNA, RNA, protein and small molecules. Product ID: 4062.
Nevada, Texas, USA
10058-F4
Cell permeable c-Myc-Max dimerization inhibitor. Inhibits proliferation, induces apoptosis and arrests cells in G0/G1 in rat1a-c-Myc cells. Also reduces tumor growth in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 403811-55-2. Pack Sizes: 10mg, 50mg. Molecular Formula: C12H11NOS2. US Biological Life Sciences.
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10-DEBC hydrochloride
10-DEBC hydrochloride is a selective and reversible Akt/PKB inhibitor suppressing the IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at 2.5 μM), and inhibiting downstream activation of mTOR, p70 S6 kinase and S6 ribosomal protein. 10-DEBC hydrochloride inhibits cell growth (IC50 ~ 2-6 μM) and leads to apoptosis in rhabdomyosarcoma cells. Synonyms: 10H-Phenoxazine-10-butanamine, 2-chloro-N,N-diethyl-, hydrochloride (1:1); Akt Inhibitor X; 2-Chloro-N,N-diethyl-10H-phenoxazine-10-butanamine hydrochloride; 10-[4'-(N,N-Diethylamino)butyl]-2-chlorophenoxazine hydrochloride; 4-(2-chloro-10H-phenoxazin-10-yl)-N,N-diethylbutan-1-amine hydrochloride. Grades: ≥99% by HPLC. CAS No. 925681-41-0. Molecular formula: C20H25N2OCl.HCl. Mole weight: 381.34.
10-DEBC hydrochloride
Selective inhibitor of Akt/PKB. Inhibits IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at 2.5uM), suppressing downstream activation of mTOR, p70 S6 kinase and S6 ribosomal protein. Shows no activity at PDK1, SGK1 or PI 3-kinase. Inhibits cell growth (IC50 ~ 2-6uM) and induces apoptosis in rhabdomyosarcoma cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 925681-41-0. Pack Sizes: 10mg, 50mg. Molecular Formula: C20H25N2OCl.HCl, Method for Determining. US Biological Life Sciences.
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10-Gingerol
10-Gingerol is an AMPK agonist, which is found in the ginger oleoresin from fresh rhizome with anti-inflammatory, antioxidant and anti-proliferative activities. 10-Gingerol suppresses neointimal hyperplasia and inhibits vascular smooth muscle cell proliferation. 10-Gingerol exhibits substantial scavenging activities with an IC 50 value of 10.47 μM against DPPH radical, an IC 50 value of 1.68 μM against superoxide radical and an IC 50 value of 1.35 μM against hydroxyl radical. 10-Gingerol inhibits the proliferation of MDA-MB-231 tumor cell line with an IC 50 of 12.1 μM. 10-Gingerol suppresses the proliferation, migration, invasion, and induced apoptosis through targeting the PI3K/Akt signaling pathway in MDA-MB-231/IR cells. 10-Gingerol is promising for research of ulcerative colitis [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. CAS No. 23513-15-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 20 mg. Product ID: HY-N0448.
(11,12,12,6α-Methyl-D6)-Prednisolone
(11,12,12,6α-Methyl-D6)-Prednisolone is the labeled analogue of 6α-Methyl Prednisolone (M325934), a glucocorticoid which displays anti-inflamatory and antioxidant properties and attenuates apoptosis in oligodendrocytes after injury. 6α-Methyl Prednisolone is neuroprotective. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 5mg. Molecular Formula: C22H24D6O5, Molecular Weight: 380.51. US Biological Life Sciences.
1-[[ (1, 1-dimethylethyl) dimethylsilyl]oxy]-11, 17-dihydroxy-6-methyl-pregna-1, 4-diene-3, 20-dione is an intermediate in the synthesis of 17-Dehydroxy-6α-methyl-11-oxo Prednisolone 21-Acetate which is a metabolite of 6α-Methyl Prednisolone (M325934); a glucocorticoid which displays anti-inflammatory and antioxidant properties and attenuates apoptosis in oligodendrocytes after injury. Also neuroprotective. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg, 50mg. Molecular Formula: C28H44O5Si. US Biological Life Sciences.
Targretin analog, has been shown to induce apoptosis in certain leukemia cell lines. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences.
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11-Aminoundecanoic acid
11-Aminoundecanoic Acid is used to prepare thapsigargin analogues targeting apoptosis to prostatic cancer cells. It is also used to synthesize N-carboxyalkylpeptides containing extended alkyl residues at P1'as matrix metalloproteinase inhibitors. Synonyms: ω-Aminoundecanoic acid; Undecanoic acid, 11-amino-; 11-Aminoundecylic acid; 11-amino-undecanoic acid; H-11-Aun-OH. Grades: ≥ 99% (Titration). CAS No. 2432-99-7. Molecular formula: C11H23NO2. Mole weight: 201.31.
1-[1-Deoxy-2,3:4,5-bis-O-(1-methylethylidene)- β-D-fructopyranos-1-yl]-L-proline is an intermediate in the synthesis of Fructose-proline diastereomer mixture (F792565). Fructose-proline is an Amadori compound, that has the potential to alter cellular adhesion, inhibit cancer metastasis and induce apoptosis. Group: Biochemicals. Grades: Highly Purified. CAS No. 173966-36-4. Pack Sizes: 25mg, 50mg. Molecular Formula: C17H27NO7. US Biological Life Sciences.
1-[1-Deoxy-2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranos-1-yl]-L-proline is an intermediate in the synthesis of Fructose-proline diastereomer mixture. Fructose-proline is an Amadori compound, that has the potential to alter cellular adhesion, inhibit cancer metastasis and induce apoptosis. Synonyms: 1-[1-Deoxy-2,3:4,5-bis-O-(1-methylethylidene)-beta-D-fructopyranos-1-yl]-L-proline; 173966-36-4. CAS No. 173966-36-4. Molecular formula: C17H27NO7. Mole weight: 357.4.
11-Keto β-Boswellic Acid
A constitutent of frankincense (olibanum) with anti-inflammatory properties. It has been shown to trigger apoptosis via a pathway dependent on caspase-8 activation but independent on Fas/Fas ligand interaction in colon cancer HT-29 cells. Group: Biochemicals. Alternative Names: (3α,4 β)-3-Hydroxy-11-oxours-12-en-23-oic Acid; 3α-Hydroxy-11-oxours-12-en-24-oic Acid; 11-Oxo- β-boswellic Acid; 11-keto- β-Boswellic Acid. Grades: Highly Purified. CAS No. 17019-92-0. Pack Sizes: 5mg. US Biological Life Sciences.
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1-(1-Methylethyl)-1H-benzimidazole-2-methanol
1-(1-Methylethyl)-1H-benzimidazole-2-methanol is a reagent used in the synthesis of new benzimidazole-thiazolidinedione hybrids as cytotoxic potential and apoptosis against a selected human cancer cell lines of prostate, breast, lung, and normal epithelial cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 305347-19-7. Pack Sizes: 1g, 5g. Molecular Formula: C11H14N2O, Molecular Weight: 190.24. US Biological Life Sciences.
12-[[ (1, 1-Dimethylethyl) dimethylsilyl]oxy]-3, 15-dihydroxy-cholest-5-en-26-oic Acid is an intermediate in the synthesis of (25R)-3 β, 7α, 12α-Trihydroxy-5-cholestenoic Acid (T795130), which is an oxysterol, an oxidized derivatives of cholesterol (C432501), which may be important in many biological processes, including cholesterol homeostasis, atherosclerosis, sphingolipid metabolism, platelet aggregation, apoptosis, and protein prenylation,[1] though their roles are poorly understood. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 2.5mg. Molecular Formula: C33H58O5Si. US Biological Life Sciences.
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1-(2,4-Dihydroxy-3-propylphenyl)ethanone
1-(2,4-Dihydroxy-3-propylphenyl)ethanone is a reactant used in the synthesis of 2-hydroxychalcones which affect cell growth inihibition , initiates apoptosis in human tumor cell lines. Group: Biochemicals. Grades: Highly Purified. CAS No. 40786-69-4. Pack Sizes: 1g, 2.5g. Molecular Formula: C11H14O3. US Biological Life Sciences.
1,2-Cyclopentanediol, 3-(6-amino-9H-purin-9-yl)-5- (hydroxymethyl)-4-methylene-, (1R,2S,3R,5R)-, a biomedical industry hopeful, has been theorized for cancerous tumor therapy. Anti-proliferative effects have surfaced with in vitro assays of lung, breast, and colon cancer cells, but further exploration is required to illuminate its cancerous tumor treatment potential through cell division suppression and apoptosis induction. Synonyms: 1,2-Cyclopentanediol, 3-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)-4-methylene-, (1R,2R,3R,5R)-(9CI); (1R,2S,3R,5R)-3-(6-Amino-9H-purin-9-yl)-5-(hydroxymethyl)-4-methylene-1,2-cyclopentanediol. CAS No. 847651-72-3. Molecular formula: C12H15N5O3. Mole weight: 277.28.
1,2-Dihydroxymelatonin
1,2-Dihydroxymelatonin is a metabolite of Melatonin (M215000), which is a hormone found in animals, plants, and microbes. Melatonin has complex effects on apoptotic pathways, inhibiting apoptosis in immune cells and neurons but enhancing apoptotic cell death of cancer cells. Inhibits proliferation / metastasis of breast cancer cells by inhibiting estrogen receptor action. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 100mg, 1g. Molecular Formula: C13H16N2O4. US Biological Life Sciences.
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1,2-DLPC
1,2-DLPC (1,2-Dilauroyl-sn-glycero-3-phosphocholine) is a ligand for LRH-1 agonists. 1,2-DLPC is a phospholipid used in the synthesis of liposomes. 1,2-DLPC enhances fat breakdown and apoptosis in fat cells through a TNFα -dependent pathway, while also inhibiting palmitate-induced insulin resistance through PPARα -mediated inflammation in muscle cells [1] [2] [3]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: 1,2-Dilauroyl-sn-glycero-3-phosphocholine. CAS No. 18194-25-7. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-107737.
12-HETE
12-HETE, a major metabolic product of arachidonic acid using 12-LOX catalysis, inhibits cell apoptosis in a dose-dependent manner. 12-HETE promotes the activation and nuclear translocation of NF-κB through the integrin-linked kinase (ILK) pathway [1].12-HETE has both anti-thrombotic and pro-thrombotic effects [2]. 12-HETE is a neuromodulator [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 71030-37-0. Pack Sizes: 50 μg (312.04 μM * 0.5 mL in Ethanol); 100 μg (312.04 μM * 1 mL in Ethanol). Product ID: HY-113439.
12-Hydroxy-3-oxo-cholest-4-en-26-oic Acid
12-Hydroxy-3-oxo-cholest-4-en-26-oic Acid is an intermediate in the synthesis of (25R)-3 β, 7α, 12α-Trihydroxy-5-cholestenoic Acid (T795130), which is an oxysterol, an oxidized derivatives of cholesterol (C432501), which may be important in many biological processes, including cholesterol homeostasis, atherosclerosis, sphingolipid metabolism, platelet aggregation, apoptosis, and protein prenylation,[1] though their roles are poorly understood. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 2.5mg. Molecular Formula: C27H40O4. US Biological Life Sciences.
1,3,5-Tri-O-benzoyl-2-O-(1H-imidazol-1-ylsulfonyl)-α-L-ribofuranose is a compound of immense significance in the biomedical sector, as it serves as a synthetic intermediate for the preparation of nucleoside analogues. Its potential as an anticancer agent has been explored by researchers due to its ability to inhibit DNA synthesis and trigger apoptosis in cancerous cells, conferring promise as an effective chemotherapeutic agent against malignancies. Consequently, this compound holds immense potential for cancer research and drug development, and its further examination is recommended. Synonyms: α-L-Ribofuranose, 1,3,5-tribenzoate 2-(1H-imidazole-1-sulfonate); 1,3,5-tri-O-benzoyl-2-O-(2-imidazolylsulfonyl)-α-L-ribofuranose; 1-O,3-O,5-O-Tribenzoyl-2-O-(1H-imidazole-1-ylsulfonyl)-alpha-L-ribofuranose; α-L-Ribofuranose, 2-O-(1H-imidazol-1-ylsulfonyl)-, 1,3,5-tribenzoate. Grades: ≥95%. CAS No. 171720-99-3. Molecular formula: C29H24N2O10S. Mole weight: 592.57.
1,3,5-Tri-O-benzoyl-a-D-ribofuranose
1,3,5-Tri-O-benzoyl-a-D-ribofuranose is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis , etc [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 22224-41-5. Pack Sizes: 10 mM * 1 mL; 5 g; 10 g. Product ID: HY-W013728.
13-Acetyl-9-dihydrobaccatin-III
13-Acetyl-9-dihydrobaccatin-III is an apoptosis inducer. Group: Biochemicals. Grades: Highly Purified. CAS No. 142203-65-4. Pack Sizes: 5mg, 10mg. Molecular Formula: C33H42O12. US Biological Life Sciences.
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1,3-Dipalmitoyl-rac-glycerol
1,3-Dipalmitoyl-rac-glycerol is a diacylglycerol that contains palmitic acid at the sn-1 and sn-3 positions. It activates protein kinase C α (PKCα) in vitro (Ka = 3.8 μM). 1,3-Dipalmitoyl-rac-glycerol (0.25-2 μM) inhibits apoptosis and production of reactive oxygen species (ROS) and pro-inflammatory mediators induced by oxygen-glucose deprivation and reperfusion (OGD/R) in SH-SY5Y neuroblastoma cells. An acyl acceptor for the unspecific bifunctional wax ester synthase/acyl-CoA:Diacylglycerol acyltransferase. Synonyms: 1,3-Dipalmitin; Dipalmitin; 1,3-Dipalmitoyl-glycerol; Glyceryl 1,3-dipalmitate. Grades: ≥98%. CAS No. 502-52-3. Molecular formula: C35H68O5. Mole weight: 568.91.
1-(3'-O-[4,4'-Dimethoxytrityl]-alpha-L-threofuranosyl)-thymine is a nucleoside analog commonly used in the development of antiviral and antitumor drugs. It has been found to effectively treat viral infections such as HIV and hepatitis B or C, as well as different types of cancer. Its mechanism of action involves inhibiting viral replication and inducing apoptosis in cancer cells. Synonyms: 3'-O-DMT-T-TNA; 1-(3'-O-[4,4'-dimethoxytrityl]-α-L-threofuranosyl)-thymine; 1-{3'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-α-L-threofuranosyl}thymine; 1-{(2R,3R,4S)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-hydroxy-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione. Grades: ≥95%. CAS No. 325683-89-4. Molecular formula: C30H30N2O7. Mole weight: 530.57.
1400W Dihydrochloride
1400W dihydrochloride is the dihydrochloride form of 1400W (HY-18730). 1400W is a slow, tight binding, and highly selective inducible nitric-oxide synthase ( iNOS ) inhibitor, with a K d value ≤ 7 nM. 1400W inhibits iNOS induction in microglial cells, and reduces generation of NO, thereby mitigating oxidative stress and neuronal cell apoptosis in the rat cerebral cortex, and improving the spatial memory dysfunction caused by acute hypobaric hypoxia-reoxygenation [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 214358-33-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18731.
14-3-3η Protein inhibitor 1
14-3-3η Protein inhibitor 1 (Compound C11) is a 14-3-3η protein inhibitor with a K D of 35 μM. 14-3-3η Protein inhibitor 1 shows inhibitory activities against several typical human liver cancer cell lines. 14-3-3η Protein inhibitor 1 induces cell apoptosis and G1-S cell cycle arrest with good metabolic stability [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2770842-10-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-146302.
1,4:6,3-Glucarodilactone
1,4:6,3-Glucarodilactone is a compound of significant value in the realms of biomedicine, finding wide application in the formulation of therapeutic drugs. By virtue of its ability to impede enzymatic activity, this compound effectively induces cellular apoptosis while concurrently curbing tumor cells proliferation. Synonyms: D-Glucaric acid 1,4:6,3-dilactone. CAS No. 826-91-5. Molecular formula: C6H6O6. Mole weight: 174.11.
14-Deoxyandrographolide
14-Deoxyandrographolide is a diterpene with calcium channel blocking activity and acts as a uterine smooth muscle relaxant. 14-Deoxyandrographolide stimulates the release of nitric oxide (NO) in endothelial cells. 14-Deoxyandrographolide gradually desensitizes liver cells to TNF-α mediated apoptosis by inducing the release of TNFRSF1A [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 4176-97-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N4323.
15-Acetoxyscirpenol
15-Acetoxyscirpenol is a trichothecene mycotoxin and an apoptosis inducer. Group: Biochemicals. Grades: Highly Purified. CAS No. 2623-22-5. Pack Sizes: 1mg, 5mg. Molecular Formula: C17H24O6, Molecular Weight: 324.37. US Biological Life Sciences.
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15-Acetoxyscirpenol
15-acetoxyscirpenol, one of acetoxyscirpenol moiety mycotoxins (ASMs), strongly induces apoptosis and inhibits Jurkat T cell growth in a dose-dependent manner by activating other caspases independent of caspase-3 [1]. Uses: Scientific research. Group: Natural products. CAS No. 2623-22-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N6681.
1,5-Diacetoxynaphthalene
1,5-Diacetoxynaphthalene is an intermediate in the synthesis of Plumbagin-d3 (P627002). Plumbagin-d3 is labelled Plumbagin (P627000) which induces apoptosis in cancer cells. It also inhibits NADPH oxidase 4 in a time- and dose-dependent manner. Group: Biochemicals. Grades: Highly Purified. CAS No. 605-89-0. Pack Sizes: 10g, 25g. Molecular Formula: C14H12O4. US Biological Life Sciences.
Worldwide
1,5-Diepi-adenophorine
1,5-Diepi-adenophorine is a natural compound that boasts remarkable anti-inflammatory, antioxidant, and neuroprotective properties. A key molecule in the fight against neurological disorders, it has earned its stripes in treating Alzheimer's and Parkinson's diseases through its ability to inhibit the activity of acetylcholinesterase. Yet its antitumor capabilities cannot be overlooked as 1,5-Diepi-adenophorine has displayed a unique ability to induce cell cycle arrest and apoptosis in various cancer cell lines. The evidence is clear - 1,5-Diepi-adenophorine is a multifaceted agent for high-value therapeutics and treatments.
1,5-Isoquinolinediol
1,5-Isoquinolinediol is a PARP1 inhibitor (IC50 value 0.39 - 1.00 μM) and neuroprotective agent leading to an increase up to 8-fold in the absolute frequency of gene targeting in the correction of the mutation at the stable integrated HSV tk gene in mouse Ltk cells. 1,5-Isoquinolinediol is also an inducible nitric oxide synthase (NOS2) inhibitor. 1,5-Isoquinolinediol significantly inhibited mitochondrial membrane potential loss, AIF (apoptosis inducing factor) and cytochrome c release from the mitochondria. Uses: Poly(adp-ribose) polymerase inhibitors. Synonyms: 1,5-Dihydroxyisoquinoline; Isoquinoline-1,5-diol; 5-Hydroxy-1(2H)-isoquinolinone; 5-Hydroxyisocarbostyril. Grades: 99%. CAS No. 5154-2-9. Molecular formula: C9H7NO2. Mole weight: 161.16.
16-Hydroxycleroda-3,13-dien-15,16-olide
16-Hydroxycleroda-3,13-dien-15,16-olide is extracted from the unripe fruits of Polyalthia longifolia var. pendula. It is used as a candidate for autophagy inducers which can cause cell death in an alternative or supplement medicine for cancer therapy. It displays promising NO inhibitory activity at 10 ug/mL and shows anti-inflammatory activity. It induces apoptosis in CML K562 cells and regulates the expression of histone-modifying enzymes PRC2 complex. Synonyms: 5-Hydroxy-4-[2-[[(1S)-1,2,3,4,4a,7,8,8abeta-octahydro-1alpha,2alpha,4aalpha,5-tetramethylnaphthalen]-1-yl]ethyl]furan-2(5H)-one. Grades: 98.0%. CAS No. 141979-19-3. Molecular formula: C20H30O3. Mole weight: 318.45.
1,6-O-[(1R,2R)-1,2-Dimethoxy-1,2-dimethyl-1,2-ethanediyl]-3,4-O-[(1S,2S)-1,2-dimethoxy-1,2-dimethyl-1,2-ethanediyl]-5-benzoate-myo-inositol, a potential anti-neoplastic agent, is currently in preclinical trials. It exhibits remarkable effectiveness against leukemia, ovarian, and breast cancer cells by impeding cellular proliferation and eliciting apoptosis. However, its clinical utility demands further investigation to establish its validity under various experimental conditions. CAS No. 1068088-78-7. Molecular formula: C25H36O11. Mole weight: 512.55.
17-AAG
17-AAG is an antibiotic with antineoplastic activity that inhibits heat shock protein 90 (HSP90). It was shown to induce apoptosis of mouse lymphoma cancer stem cells (CSCs) and human acute myeloid leukemia (AML) CSCs. Synonyms: Tanespimycin; 17-Allylaminogeldanamycin; BAY 579352; 17-(Allylamino) Geldanamycin; 17-Demethoxy-17-(2-propenylamino)geldanamycin; 17-(Allylamino)-17-demethoxygeldanamycin; 17-Demethoxy-17-allylaminogeldanamycin; CP 127374; NSC 330507; Tanespimycin; 17AAG. Grades: >98%. CAS No. 75747-14-7. Molecular formula: C31H43N3O8. Mole weight: 585.69.
17-AAG
Potent, less toxic analog of geldanamycin. Inhibits the essential ATPase activity of HSP90. Telomerase activity inhibitor. Apoptosis inducer and antitumor compound. Group: Biochemicals. Grades: Highly Purified. CAS No. 75747-14-7. Pack Sizes: 1mg, 5mg. US Biological Life Sciences.
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17-AAG hydrochloride
17-AAG hydrochloride is a potent HSP90 inhibitor with IC50 value of 5 nM, which is a 100-fold higher binding affinity for HSP90 derived from tumour cells than that from normal cells. It is less toxic by binding to Hsp90 and altering its function. It causes the degradation of HER2, HER3, Akt, and both mutant and wild-type androgen receptor (AR), leading to the RB-dependent G1 growth arrest of prostate cancer cells. It has the ability to induce apoptosis of cells transformed with imatinib mesylate-resistant T315I and E255K BCR-ABL mutants with IC50 values of 2.3 μM and 1.0 μM, respectively. It displays significantly higher binding affinity for Hsp90 from 3T3-src, B16 or CT26 xenografts in nude mice compared with that from the normal tissues in vivo. Uses: 17-aag hydrochloride has the ability to induce apoptosis of cells transformed with imatinib mesylate-resistant t315i and e255k bcr-abl mutants. Synonyms: 17-AAG hydrochloride; 17 AAG hydrochloride; 17AAG hydrochloride; [(3R,5S,6R,7S,8E,10S,11S,12Z,14E)-6-hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-21-(prop-2-enylamino)-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate hydrochloride;Tanespimycin Hydrochloride;NSC 330507 Hydrochloride;CP 127374 Hydrochloride;17-(Allylamino)-17-desmethylgeldanamycin hydrochloride. Grades: >98%. CAS No. 911710-03-7. Molecular formula: C31H44ClN3O8. Mole weight: 622.15.
17-(Allylamino-d5) Geldanamycin
Potent inhibitor of heat shock protein 90 (Hsp90). 17-AAG is a less toxic analog than Geldanamycin. It induces apoptosis and displays antitumor effects. 17-AAG inhibits the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2. Group: Biochemicals. Alternative Names: 17-Demethoxy-17-(2-propenylamino-d5)geldanamycin; 17-(Allylamino-d5)-17-demethoxygeldanamycin; 17-(Allylamino-d5)-17-desmethylgeldanamycin; 17-Demethoxy-17-(allylamino-d5)geldanamycin; 17AAG-d5; CP 127374-d5; KOS 953-d5; NSC 330507-d5; Tanespimycin-d5. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
17-(Allylamino) Geldanamycin
Potent inhibitor of heat shock protein 90 (Hsp90). 17-AAG is a less toxic analog than Geldanamycin. It induces apoptosis and displays antitumor effects. 17-AAG inhibits the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2. Group: Biochemicals. Alternative Names: 17-Demethoxy-17- (2-propenylamino) geldanamycin; 17-(Allylamino)-17-demethoxygeldanamycin; 17-(Allylamino)-17-desmethylgeldanamycin; 17-Demethoxy-17-allyl aminogeldanamycin; 17AAG; CP 127374; KOS 953; NSC 330507; Tanespimycin; 17-AAG. Grades: Highly Purified. CAS No. 75747-14-7. Pack Sizes: 1mg, 10mg, 25mg, 100mg. Molecular Formula: C31H43N3O8, Molecular Weight: 585.69. US Biological Life Sciences.
17-Dehydroxy 11-O-Trimethylsilyl 6α-Methyl Prednisolone is an intermediate in synthesizing 6α-Methyl Prednisolone 17-Deshydroxy 17 β-Carboxylic Acid (M327485), a compound derived from 6α-Methyl Prednisolone (M325934), which is a glucocorticoid, which displays anti-inflammatory and antioxidant properties and attenuates apoptosis in oligodendrocytes after injury. 6α-Methyl Prednisolone is neuroprotective. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 100mg, 250mg. Molecular Formula: C25H38O4Si. US Biological Life Sciences.
17-Dehydroxy-6α-methyl-11-oxo Prednisolone 21-Acetate is a metabolite of 6α-Methyl Prednisolone (M325934); a glucocorticoid which displays anti-inflammatory and antioxidant properties and attenuates apoptosis in oligodendrocytes after injury. Also neuroprotective. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg, 100mg. Molecular Formula: C24H30O5. US Biological Life Sciences.
Less toxic, more potent synthetic derivative of geldanamycin. Angiogenesis inhibitor. Heat shock protein 90 (HSP90) inhibitor. Apoptosis inducer. Shows higher antitumor activity than 17-AAG. Group: Biochemicals. Grades: Highly Purified. CAS No. 467214-20-6. Pack Sizes: 100ug, 1mg. US Biological Life Sciences.
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17-ODYA
17-ODYA is a CYP450 ω-hydroxylase inhibitor. 17-ODYA is also a potent inhibitor (IC 50 <100 nM) of the formation of 20-hydroxyeicosatetraenoic acid (20-HETE), epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids by rat renal cortical microsomes incubated with arachidonic acid. 17-ODYA completely attenuates the isoproterenol (ISO)-induced apoptosis, and necrosis in cultured cardiomyocytes [1] [2] [3]. 17-ODYA is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 34450-18-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-101016.
1-Boc-L-Prolinamide
1-Boc-L-prolinamide is a reagent that is used in the preparation of thiazole amide peptidomimetics as erratum inhibitor apoptosis protein antagonist. Group: Biochemicals. Grades: Highly Purified. CAS No. 35150-07-3. Pack Sizes: 100mg, 5 g. Molecular Formula: C10H18N2O3, Molecular Weight: 214.26. US Biological Life Sciences.
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1- (Cyclopropylmethyl) piperazine
1- (Cyclopropylmethyl) piperazine is a compound involved in the preparation of N-substituted piperazinopyridyl steroid derivatives as abiraterone analogs that inhibit growth and induce pro-apoptosis in human hormone-independent prostate cancer cell lines. Group: Biochemicals. Grades: Highly Purified. CAS No. 57184-25-5. Pack Sizes: 250mg, 1g. Molecular Formula: C8H16N2, Molecular Weight: 140.229999999999. US Biological Life Sciences.
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1-Demethylcolchicine
1-Demethylcolchicine is a derivative of Colchicine (C640000) an antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway. Group: Biochemicals. Grades: Highly Purified. CAS No. 3464-68-4. Pack Sizes: 10mg, 50mg. Molecular Formula: C21H23NO6, Molecular Weight: 385.41. US Biological Life Sciences.
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1-Methoxy-5-(methoxymethoxy)-naphthalene
1-Methoxy-5-(methoxymethoxy)-naphthalene is an intermediate in the synthesis of Plumbagin-d3 (P627002). Plumbagin-d3 is labelled Plumbagin (P627000) which induces apoptosis in cancer cells. It also inhibits NADPH oxidase 4 in a time- and dose-dependent manner. Group: Biochemicals. Grades: Highly Purified. CAS No. 78176-48-4. Pack Sizes: 250mg, 500mg. Molecular Formula: C13H14O3. US Biological Life Sciences.
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1-Methyl-3'-deoxyadenosine
1-Methyl-3'-deoxyadenosine is a vital compound used in the biomedical industry for its potential therapeutic applications. It has been found to exhibit anticancer properties by inducing apoptosis and inhibiting tumor cell growth. Additionally, 1-Methyl-3'-deoxyadenosine has demonstrated immunosuppressive effects, making it a promising candidate for the treatment of autoimmune diseases. Synonyms: (2R,3R,5S)-2-(6-amino-1-methyl-1,2-dihydro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3-ol. Molecular formula: C11H17N5O3. Mole weight: 267.29.
1-Methyl-d3 Isonicotinamide Chloride
1-Methyl-d3 Isonicotinamide Chloride is the isotope labelled analog of 1-Methyl Isonicotinamide Chloride (M314380); a derivative of Isonicotinamide (I821700) which is an isomeric analogue of nicotinamide and a metabolite of isonicotinic thioamide. Isonicotinamide strongly induced apoptosis in human acute myelomonocytic leukemia cells, HL-60. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C7H6D3ClN2O, Molecular Weight: 175.63. US Biological Life Sciences.
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1-Methyl Isonicotinamide Chloride
1-Methyl Isonicotinamide Chloride is a derivative of Isonicotinamide (I821700); an isomeric analogue of nicotinamide and a metabolite of isonicotinic thioamide. Isonicotinamide strongly induced apoptosis in human acute myelomonocytic leukemia cells, HL-60. Group: Biochemicals. Grades: Highly Purified. CAS No. 7680-68-4. Pack Sizes: 100mg, 1g. Molecular Formula: C7H9ClN2O, Molecular Weight: 172.61. US Biological Life Sciences.
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1-Monopalmitolein
1-Palmitoleoyl glycerol is a biologically active monoacylglycerol. It increases daunomycin accumulation, shown to inhibit P-glycoprotein in Caco-2 cells. 1-Palmitoleoyl glycerol induces thymocyte apoptosis. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: Glyceryl palmitoleate. CAS No. 37515-61-0. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-133948.
1,N6-Etheno-9-(b-D-xylofuranosyl)adenosine
1,N6-Etheno-9-(b-D-xylofuranosyl)adenosine is a unique biomolecule used in biomedicine for its potential as an anticancer agent. Studies have shown that this compound can induce apoptosis in cancer cells without harming healthy cells, making it an attractive option for cancer treatment. Its structure is similar to the naturally occurring adenosine, which allows it to specifically target cancer cells. Ongoing research is exploring its potential for the treatment of various types of cancer such as lung cancer, colon cancer, and leukemia. Synonyms: 1,N6-Etheno-9-(β-D-xylofuranosyl)adenosine; (2R,3R,4R,5R)-2-(hydroxymethyl)-5-(3H-imidazo[2,1-i]purin-3-yl)tetrahydrofuran-3,4-diol. Grades: ≥95%. CAS No. 2095417-39-1. Molecular formula: C12H13N5O4. Mole weight: 291.26.
1,N6-Ethenoadenosine
N6-Ethenoadenosine, a purine nucleoside analog, is paramount for the examination of oxidative damage on cellular DNA. It has demonstrated a capability to initiate DNA damage and apoptosis in cancer cells, rendering it an integral component of investigating its effectiveness as an anticancer agent. Its potential usage within the realm of cancer treatment necessitates a thorough understanding and exploration of its capabilities. Synonyms: N6-Etheno-D-adenosine; N6-Ethenoadenosine; 3-(β-D-Ribofuranosyl)-3H-imidazo[2,1-i]purine; (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(3H-imidazo[2,1-i]purin-3-yl)tetrahydrofuran-3,4-diol. Grades: ≥95% by HPLC. CAS No. 39007-51-7. Molecular formula: C12H13N5O4. Mole weight: 291.26.
1-O-Octadecyl-2-O-methyl-rac-glycerol
1-O-Octadecyl-2-O-methyl-rac-glycerol is used to prepare Edelfosine, a rapid inducer of apoptosis in human leukemic cells. Edelfosine has been considered as a promising drug in cancer treatment. It is also used to prepare phospholipids containing nitrogen homologs with antitumor activities. Group: Biochemicals. Grades: Highly Purified. CAS No. 84337-43-9. Pack Sizes: 50mg, 250mg. Molecular Formula: C22H46O3, Molecular Weight: 358.6. US Biological Life Sciences.
1-Piperazineacetic Acid 2- [ [2-Hydroxy-3- (2-propen-1-yl) phenyl] methylene] hydrazide-d8 is deuterium labelled 1-Piperazineacetic Acid 2- [ [2-Hydroxy-3- (2-propen-1-yl) phenyl] methylene] hydrazide (H953060) and has been employed to characterize the in vivo and in vitro metabolic profile of PAC-1 (P132000), an anti-tumor agent that induces apoptosis. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 5mg. Molecular Formula: C16H14D8N4O2, Molecular Weight: 310.42. US Biological Life Sciences.
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1-Pyrrolidinecarbodithio ic Acid Ammonium Salt
1-Pyrrolidinecarbodithio ic Acid induces apoptosis in rat smooth muscle cells and inhibits apoptosis in leukemia HL-60 cells. It also prevents induction of nitric oxide synthetase by inhibiting translation of NOS mRNA. Group: Biochemicals. Grades: Highly Purified. CAS No. 5108-96-3. Pack Sizes: 15g, 100g. Molecular Formula: C5H12N2S2. US Biological Life Sciences.
Worldwide
1-Stearoyl-sn-glycero-3-phosphocholine
1-Stearoyl-sn-glycero-3-phosphocholine is a lysophosphatidylcholine that inhibits HDAC3 activity and phosphorylation of STAT3 in K562 cells. 1-Stearoyl-sn-glycero-3-phosphocholine induces apoptosis and exhibits anticancer activity in chronic myelogenous leukemia (CML) K562 cells [1]. Uses: Scientific research. Group: Natural products. CAS No. 19420-57-6. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-125771.
20-Deoxo-20α-hydroxy-6α-Methyl Prednisolone
20-Deoxo-20α-hydroxy-6α-Methyl Prednisolone is an impurity of 6α-Methyl Prednisolone (M325930), a glucocorticoid which displays anti-inflamatory and antioxidant properties and attenuates apoptosis in oligodendrocytes after injury. 6α-Methyl Prednisolone is neuroprotective. Group: Biochemicals. Grades: Highly Purified. CAS No. 387-66-6. Pack Sizes: 2.5mg, 10mg. Molecular Formula: C22H32O5, Molecular Weight: 376.49. US Biological Life Sciences.
Worldwide
20-Deoxo-20 β-hydroxy-6α-Methyl Prednisolone
20-Deoxo-20 β-hydroxy-6α-Methyl Prednisolone is an impurity of 6α-Methyl Prednisolone (M325930), a glucocorticoid which displays anti-inflamatory and antioxidant properties and attenuates apoptosis in oligodendrocytes after injury. 6α-Methyl Prednisolone is neuroprotective. Group: Biochemicals. Grades: Highly Purified. CAS No. 387-65-5. Pack Sizes: 2.5mg, 25mg. Molecular Formula: C22H32O5, Molecular Weight: 376.49. US Biological Life Sciences.
Worldwide
20-Hydroxyecdysone
A member of the ecdysteroid family. Ecdysone receptor (EcR) agonist. More potent than ecdysone. Induces the expression of genes coding for proteins that the larva requires, and it causes chromosome puffs (sites of high expression) to form in polytene chromosomes. Plays a key role in insect development, cell proliferaton, growth and apoptosis by controlling gene expression involved in moulting and metamorphosis. It acts through a heterodimeric receptor comprising the ecdysone receptor and the ultraspiracle proteins (USP). Regulates lipolysis in insects. Appears in many plants mostly as a protection agent (toxins or antifeedants) against herbivorous insects. Used for controlled gene expression in scientific research, agriculture and medicine. Used for the development of selective insect growth regulators for use as environmentally benign insecticides. Shows biological effects on mammalian species. Neurosteroid. Antiepileptic. Acts on the modulatory site of the GABAA receptor and potentia Group: Biochemicals. Grades: Highly Purified. CAS No. 5289-74-7. Pack Sizes: 5mg, 10mg, 50mg. Molecular Formula: C27H44O7. US Biological Life Sciences.
Worldwide
20(R)-Ginsenoside Rg3-d6
20(R)-Ginsenoside Rg3-d6 is the labelled version of 20(R)-Ginsenoside Rg3, which causes an inhibition of phosphatidylinositol 3-kinase/Akt activation that, in turn, results in modulations in Bcl-2 family proteins in such a way that the apoptosis of U87 cells are regulated, relating to in vivo inhibition of tumor angiogenesis of lung cancer. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C42H66D6O13, Molecular Weight: 791.05. US Biological Life Sciences.
Worldwide
20(R)-Ginsenoside Rh2
20(R)-Ginsenoside Rh2, a matrix metalloproteinase (MMP) inhibitor, acts as a cell antiproliferator. It has anticancer effects via blocking cell proliferation and causing G1 phase arrest. 20(R)-Ginsenoside Rh2 induces apoptosis, and has anti-inflammatory and antioxidative activity. 20(R)-Ginsenoside Rh2 inhibits the replication and proliferation of mouse and human gammaherpesvirus 68 (MHV-68) with an IC50 of 2.77 μM for murine MHV-68. Group: Inhibitors. Alternative Names: b-D-Glucopyranoside, (3b,12b,20R)-12,20-dihydroxydammar-24-en-3-yl; (3beta,12beta)-12,20-dihydroxydammar-24-en-3-yl beta-d-glucopyranoside; 20-(R)-Ginsenoside Rh2; 20(R)-Ginsenoside Rh2; 20(R)-GINSENOSIDERH2; Ginsenoside-Rh2; Ginsenoside Rh2, 20(R)-; 20(R)-Ginsenoside-Rh2; (R) Ginsenoside Rh2. CAS No. 112246-15-8. Molecular formula: C36H62O8. Mole weight: 622.88. Appearance: Powder. Purity: 0.98. IUPACName: (2R, 3R, 4S, 5S, 6R)-2-[[(3S, 5R, 8R, 9R, 10R, 12R, 13R, 14R, 17S)-12-hydroxy-17-[(2R)-2-hydroxy-6-methylhept-5-en-2-yl]-4, 4, 8, 10, 14-pentamethyl-2, 3, 5, 6, 7, 9, 11, 12, 13, 15, 16, 17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)oxane-3, 4, 5-triol. Canonical SMILES: CC (=CCCC (C) (C1CCC2 (C1C (CC3C2 (CCC4C3 (CCC (C4 (C)C)OC5C (C (C (C (O5)CO)O)O)O)C)C)O)C)O)C. Catalog: ACM112246158.
20(S)-Ginsenoside F2
Ginsenoside F2 is a bioactive metabolite of the ginsenoside component of Panax ginseng with the ability to regulate element-binding protein cleavage activating protein and transforming growth factor- β pathways. This control over apoptosis can lead to a control over hair growth and hair loss in mammals. Group: Biochemicals. Grades: Highly Purified. CAS No. 62025-49-4. Pack Sizes: 10mg, 100mg. Molecular Formula: C42H72O13. US Biological Life Sciences.
Worldwide
21-tert-Butyldimethylsilyl 6α-Methyl Prednisone
21-tert-Butyldimethylsilyl 6α-Methyl Prednisone is an intermediate in the synthesis of 17-Dehydroxy-6α-methyl-11-oxo Prednisolone 21-Acetate which is a metabolite of 6α-Methyl Prednisolone (M325934); a glucocorticoid which displays anti-inflammatory and antioxidant properties and attenuates apoptosis in oligodendrocytes after injury. Also neuroprotective. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg, 25mg. Molecular Formula: C28H42O5Si. US Biological Life Sciences.
Worldwide
2,2,2-Trifluoroacetophenone
2,2,2-Trifluoroacetophenone is a fluorinated acetophenone with inhibitory activity of acetylcholinesterase. 2,2,2-Trifluoroacetophenone was shown to have neuroprotective activity by inhibiting apoptosis in cerebellar granule neurons. Group: Biochemicals. Alternative Names: (Trifluoroacetyl) benzene; 2,2,2-Trifluoro-1-phenyl-1-ethanone; 2,2,2-Trifluoro-1-phenylethanone; NSC 42752; Phenyl Trifluoromethyl Ketone; Trifluoromethyl Phenyl Ketone; α, α, α-Trifluoroacetophenone; ω, ω, ω-Trifluoroacetophenone. Grades: Highly Purified. CAS No. 434-45-7. Pack Sizes: 250mg. US Biological Life Sciences.
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