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Azulene (Cyclopentacycloheptene) is as an isomer of naphthalene with high anti-HIV activity. Azulene, isolated from the distillation of chamomile oil, is a scaffold in medicinal chemistry [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: Cyclopentacycloheptene. CAS No. 275-51-4. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-B0055.
Azulene
Azulene (Cyclopentacycloheptene) is as an isomer of naphthalene with high anti-HIV activity. Azulene, isolated from the distillation of chamomile oil, is a scaffold in medicinal chemistry. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Cyclopentacycloheptene. Product Category: Inhibitors. Appearance: Dark blue to purple crystalline powder. CAS No. 275-51-4. Molecular formula: C10H8. Mole weight: 128.17. Purity: 0.9992. Density: 1.037 g/cm³. ECNumber: 205-993-6. Product ID: ACM275514. Alfa Chemistry ISO 9001:2015 Certified.
Azulene
Azulene is an isomer of napthalene visibly identifiable by its dark blue hue. As such it is used in the preparation of dyes. Azulene is used as an additive in ointments. It is an active ingredient in cosmetics, shaving creams and other topicals. It is used as antioxidant and in anti-inflammatory activities. It is involved in the colorimetric determination of furfural. It acts as ligand for low valent metals and forms pi complexes with both cyclopentadienyl and cylcloheptatrienyl ligands in organometallic chemistry. It is also used as precursor for the preparation of (azulene)Mo2 (CO)6 and (azulene)Fe2 (CO)5. Group: Biochemicals. Alternative Names: Bicyclo[5. 3. 0]decapentaene; Cyclopentacycloheptene ; NSC 89248. Grades: Highly Purified. CAS No. 275-51-4. Pack Sizes: 250mg, 1g. Molecular Formula: C??H?, Molecular Weight: 128.17. US Biological Life Sciences.
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2-Aminoazulene
2-Aminoazulene. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 2-Aminoazulene;2-Azulenamine. Product Category: Heterocyclic Organic Compound. CAS No. 50472-20-3. Molecular formula: C10H9N. Mole weight: 143.185160 [g/mol]. Purity: 0.96. IUPACName: azulen-2-amine. Density: 1.137. Product ID: ACM50472203. Alfa Chemistry ISO 9001:2015 Certified.
(3As,8s,8ar)-3a-hydroxy-2,2,8-trimethyl-1,3,8,8a-tetrahydroazulene-5,6-dicarbaldehyde. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 9-Hydroxyvelleral, CCRIS 1707, CID57146, LS-23573, 5,6-Azulenedicarboxaldehyde, 1,2,3,3a,8,8a-hexahydro-3a-hydroxy-2,2,8-trimethyl-, (3aS-(3a-alpha,8-alpha,8a-alpha))-, 96910-73-5. Product Category: Heterocyclic Organic Compound. CAS No. 96910-73-5. Molecular formula: C15H20O3. Mole weight: 248.318 g/mol. Purity: 0.96. IUPACName: (3aS,8S,8aR)-3a-hydroxy-2,2,8-trimethyl-1,3,8,8a-tetrahydroazulene-5,6-dicarbaldehyde. Canonical SMILES: CC1C=C(C(=CC2(C1CC(C2)(C)C)O)C=O)C=O. Density: 1.215g/cm³. Product ID: ACM96910735. Alfa Chemistry ISO 9001:2015 Certified.
4,6,8-Trimethylazulene
4,6,8-Trimethylazulene. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 2,4,6-Trimethylbicyclo(5.3.0)deca-2,4,6,8,10-pentaene;Azulene, 4,6,8-trimethyl-;SALOR-INT L496081-1EA;LABOTEST-BB LT00007839;4,6,8-TRIMETHYLAZULENE;4,6,8-TRIMETHYLAZULENE 99+%. Product Category: Heterocyclic Organic Compound. CAS No. 941-81-1. Molecular formula: C13H14. Mole weight: 170.25. Product ID: ACM941811. Alfa Chemistry ISO 9001:2015 Certified.
8-Chloro-6-phenyl-4H-2,3,5,10b-tetraaza-benzo[e]azulene. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 8-CHLORO-6-PHENYL-4H-2,3,5,10B-TETRAAZA-BENZO[E]AZULENE. Product Category: Heterocyclic Organic Compound. CAS No. 53180-72-6. Molecular formula: C16H11ClN4. Mole weight: 294.73834. Product ID: ACM53180726. Alfa Chemistry ISO 9001:2015 Certified. Categories: estazolam.
Diethyl-[2-[(3-nitroazulene-1-carbonyl)amino]ethyl]azanium chloride. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 1-(2-(Diethylamino)ethyl)-3-nitroazulenecarboxamide hydrochloride, N-(2-(Diethylamino)ethyl)-3-nitro-1-azulenecarboxamide hydrochloride, 1-AZULENECARBOXAMIDE, N-(2-(DIETHYLAMINO)ETHYL)-3-NITRO-, HYDROCHLORIDE, AC1L258M, LS-23569, diethyl-[2-[(3-nitroazulene-1-carbonyl)amino]ethyl]azanium chloride, 54805-30-0. Product Category: Heterocyclic Organic Compound. CAS No. 54805-30-0. Molecular formula: C17H22ClN3O3. Mole weight: 351.828 g/mol. Purity: 0.96. IUPACName: diethyl-[2-[(3-nitroazulene-1-carbonyl)amino]ethyl]azanium;chloride. Canonical SMILES: CC[NH+](CC)CCNC(=O)C1=CC(=C2C1=CC=CC=C2)[N+](=O)[O-].[Cl-]. Product ID: ACM54805300. Alfa Chemistry ISO 9001:2015 Certified.
Guaiazulene
Guaiazulene. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 1,4-Dimethyl-7-(1-methylethyl)-azulen. Product Category: Arenes. Appearance: Solid. CAS No. 489-84-9. Molecular formula: C15H18. Mole weight: 198.3. Purity: 0.98. IUPACName: 1,4-Dimethyl-7-propan-2-ylazulene. Canonical SMILES: CC1=C2C=CC(=C2C=C(C=C1)C(C)C)C. Density: 0.976 g/mL at 25 °C(lit.). Product ID: ACM489849. Alfa Chemistry ISO 9001:2015 Certified.
1,2,3,3a,4,5,6,8a-Octahydro-2-isopropylidene-4,8-dimethylazulen-6-ol. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 1,2,3,3a,4,5,6,8a-octahydro-4,8-dimethyl-2-(1-methylethylidene)-6-azuleno;1,2,3,3a,4,5,6,8a-octahydro-4,8-dimethyl-2-(1-methylethylidene)-6-Azulenol;VETIVEROL;1H-3A,6-METHANOAZULENE-3-METHANOL, OCTAHYDRO-7,7-DIMETHYL-8-METHYLENE;1,2,3,3a,4,5,6,8a-octahyd. Product Category: Heterocyclic Organic Compound. CAS No. 89-88-3. Molecular formula: C15H24O. Mole weight: 220.35. Product ID: ACM89883. Alfa Chemistry ISO 9001:2015 Certified.
1-(3-Acetyl-4,6,8-trimethylazulen-1-yl)ethanone
1-(3-Acetyl-4,6,8-trimethylazulen-1-yl)ethanone. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 841-71-4, Azulene,1,3-diacetyl-4,6,8-trimethyl-, AC1L390A, Azulene, 1,3-diacetyl-4,6,8-trimethyl-, 1-(3-acetyl-4,6,8-trimethylazulen-1-yl)ethanone, 1,1-(4,6,8-trimethylazulene-1,3-diyl)diethanone. Product Category: Heterocyclic Organic Compound. CAS No. 841-71-4. Molecular formula: C17H18O2. Mole weight: 254.324 g/mol. Purity: 0.96. IUPACName: 1-(3-acetyl-4,6,8-trimethylazulen-1-yl)ethanone. Canonical SMILES: CC1=CC(=C2C(=CC(=C2C(=C1)C)C(=O)C)C(=O)C)C. Density: 1.08g/cm³. Product ID: ACM841714. Alfa Chemistry ISO 9001:2015 Certified.
Gibberellin A4 is a derivative of Gibberellic Acid. It is a plant growth hormone that regulates growth and differentiation of plant cells for elongation, germination and enzyme induction. Synonyms: 4a,1-(Epoxymethano)-7,9a-methanobenz[a]azulene, gibbane-1,10-dicarboxylic Acid Deriv.; GA4; 2β,4a-Dihydroxy-1-methyl-8-methylene-4aα,4bβ-gibbane-1α,10β-dicarboxylic Acid; (1α,2β,4aα,4bβ,10β)-2,4a-Dihydroxy-1-methyl-8-methylene-gibbane-1,10-dicarboxylic Acid. Grade: > 95%. CAS No. 468-44-0. Molecular formula: C19H24O5. Mole weight: 332.40.
Gibberellin A4-[d2]
Gibberellin A4-[d2] is an isotopic analog of Gibberellin A4, a plant growth hormone that regulates growth and differentiation of plant cells for elongation, germination and enzyme induction. Synonyms: 4a,1-(Epoxymethano)-7,9a-methanobenz[a]azulene, gibbane-1,10-dicarboxylic Acid Deriv.-d2; GA4-d2; 2β,4a-Dihydroxy-1-methyl-8-methylene-4aα,4bβ-gibbane-1α,10β-dicarboxylic Acid-d2; (1α,2β,4aα,4bβ,10β)-2,4a-Dihydroxy-1-methyl-8-methylene-gibbane-1,10-dicarboxylic Acid 1,4a-Lactone-d2. Grade: > 95%. CAS No. 84693-21-0. Molecular formula: C19H22O5D2. Mole weight: 334.41.
Gibberellin A8. Group: Biochemicals. Alternative Names: 2 β,3 β,4a,7-Tetrahydroxy-1-methyl-8-methylene-4aα,4b β-gibbane-1α,10 β-dicarboxylic Acid 1,4a-Lactone; Dodecahydro-2,3,4a,7-tetrahydroxy-1-methyl-8-methylene-7H-7,9a-methanobenz[a]azulene-1,10-dicarboxylic Acid 1,4a-Lactone; GA8. Grades: Highly Purified. CAS No. 7044-72-6. Pack Sizes: 10mg. Molecular Formula: C19H24O7, Molecular Weight: 364.39. US Biological Life Sciences.
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Gibberellin A9
Gibberellin A9, an influential phytohormone, serves as a ubiquitous, biologically active plant growth regulator prevalently deployed within the agricultural sectors. Synonyms: (1R,4aR,4bR,7R,9aR,10S,10aR)-1-methyl-8-methylene-13-oxododecahydro-4a,1-(epoxymethano)-7,9a-methanobenzo[a]azulene-10-carboxylic acid. Grade: 95%. CAS No. 427-77-0. Molecular formula: C19H24O4. Mole weight: 316.4.
Gibberellin A95
Gibberellin A95. Group: Biochemicals. Alternative Names: 4a,1-(Epoxymethano)-7,9a-methanobenz[a]azulene, gibb-3-ene-1,10-dicarboxylic Acid Deriv.; GA95; Gibberellin GA95; NSC 224287. Grades: Highly Purified. CAS No. 78259-50-4. Pack Sizes: 50mg. Molecular Formula: C19H22O5, Molecular Weight: 330.37. US Biological Life Sciences.
Worldwide
Gibberellin A95
Gibberellin A95 is a derivative of Gibberelic Acid. It is a stereoisomer of Gibberelin A5. Synonyms: 4a,1-(Epoxymethano)-7,9a-methanobenz[a]azulene, gibb-3-ene-1,10-dicarboxylic Acid Deriv.; GA95; NSC 224287. Grade: > 95%. CAS No. 78259-50-4. Molecular formula: C19H22O5. Mole weight: 330.38.
Giberellin A68
Giberellin A68. Group: Biochemicals. Alternative Names: 4a,1-(Epoxymethano)-7,9a-methanobenz[a]azulene Gibb-3-ene-1,10-dicarboxylic Acid Deriv.; GA68. Grades: Highly Purified. CAS No. 71177-41-8. Pack Sizes: 2.5mg. Molecular Formula: C19H22O6, Molecular Weight: 346.37. US Biological Life Sciences.
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GNE-987
GNE-987, a PROTAC connected by ligands for von Hippel-Lindau and BRD4, is used in PROTAC-Antibody Conjugate (PAC). GNE-987 shows picomolar activity of cell BRD4 degradation (DC50 = 0.03 nM for EOL-1 AML cell line), and binds equipotently to the BD1 and BD2 bromodomains of BRD4 with low nanomolar affinities (IC50s = 4.7 and 4.4 nM, respectively). It combines a potent BET binder/inhibitor, a VHL binding fragment and a 10 methylene spacer moiety. Synonyms: 7-(3,5-Difluoropyridin-2-yl)-N-(11-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-11-oxoundecyl)-2-methyl-10-((methylsulfonyl)methyl)-3-oxo-3,4,6,7-tetrahydro-2H-2,4,7-triazadibenzo[cd,f]azulene-9-carboxamide; N-[11-({7-(3,5-Difluoropyridin-2-yl)-2-methyl-10-[(methylsulfonyl)methyl]-3-oxo-3,4,6,7-tetrahydro-2H-2,4,7-triazadibenzo[cd,f]azulene-9-carbonyl}amino)undecanoyl]-3-methyl-L-valyl-(4R)-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}-L-prolinamide. Grade: ≥98%. CAS No. 2417371-71-0. Molecular formula: C56H67F2N9O8S2. Mole weight: 1096.31.
Guaiol
(?)-Guaiol is a sesquiterpene alcohol that has been found in several traditional Chinese medicinal plants and has antiproliferative, pro-autophagic, insect repellent, and insecticidal biological activities.1,2,3 It selectively inhibits proliferation of A549 and H1299 non-small cell lung carcinoma (NSCLC) cells over BEAS-2B normal lung cells (IC50s = 121.7, 211.5, and 297.1 μM, respectively).1 It also dose-dependently induces formation of DNA double-strand breaks (DSBs) and autophagy in A549 and H1299 cells and increases levels of microtubule-associated protein 1 light chain 3 isoform II (LC3-II). (?)-Guaiol (8 mg/kg three times per week) inhibits tumor growth in an NSCLC mouse xenograft model. It deters A. aegypti and A. quadrimaculatus mosquitoes from feeding on a synthetic blood substitute with a biting-deterrent index (BDI) of 0.82 when used at a concentration of 25 nmol per cm2.2 (?)-Guaiol is also lethal to fourth instar M. separata and third instar P. xylostella larvae (LD50s  Group: Biochemicals. Alternative Names: 1,2,3,4,5 β, 6, 7, 8-Octahydro-α, α, 3α, 8α-tetramethyl-5-azulenemethanolGuai-1(5)-en-11-ol; Guaiol; (3S,5R,8S)-1,2,3,4,5,6,7,8-Octahydro-α,α,3,8-t. Grades: Highly Purified. CAS No. 489-86-1. Pack Sizes: 5mg, 10mg, 25mg, 50mg. Molecular Formula: C??H??O, Molecular Weight: 222.37. US Biological Life Sciences.
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Hybridaphniphylline B
Hybridaphniphylline B, a naturally occurring product, has shown considerable potential as an immunomodulatory agent. It has been extensively studied for its anti-inflammatory and analgesic properties, with growing interest in its potential efficacy in treating various inflammatory and chronic pain conditions. Despite its proven therapeutic potential, the precise mechanism of action of Hybridaphniphylline B is still under investigation, and further research is necessary to fully understand its pharmacological properties. This remarkable natural product holds great promise for the development of novel therapeutic interventions that can improve the lives of people suffering from chronic inflammatory disorders. Synonyms: 5,14a:11,12c-Dimethano-15H-4,16-dioxa-8a-azabenzo[a]cyclopent[1',7']indeno[3'a,4':4,5]indeno[7,1-gh]azulene-15,18-dione, 3-(β-D-glucopyranosyloxy)-2a,3,4a,5,6,7,7a,8,9,10,11,12,12a,12b,13,14,16a,16b-octadecahydro-2-(hydroxymethyl)-10,12b-dimethyl-, (2aS,3S,4aR,5R,7aS,8aS,10S,11R,12aR,12bS,12cR,14aS. Grade: 98%. CAS No. 1467083-09-5. Molecular formula: C37H47NO11. Mole weight: 681.78.
(-)-Isoledene
(-)-Isoledene. Uses: Designed for use in research and industrial production. Additional or Alternative Names: (-)-Isoledene, (-)-Isoledene, 58870_ALDRICH, 58870_FLUKA, FT-0642315, 95910-36-4. Product Category: Heterocyclic Organic Compound. CAS No. 95910-36-4. Molecular formula: C15H24. Mole weight: 204.351060 [g/mol]. Purity: 0.96. IUPACName: (1aR,4R,7R,7bS)-1,1,4,7-tetramethyl-1a,2,3,4,5,6,7,7b-octahydrocyclopropa[e]azulene. Product ID: ACM95910364. Alfa Chemistry ISO 9001:2015 Certified.
Lactaroviolin
It is produced by the strain of Lactarius deliciosus. It is an aromatic derivative antibiotic. It can inhibit the growth of Mycobacterium tuberculosis, but the effect is not strong. Synonyms: Lactarioviolin; 1-Azulenecarboxaldehyde, 4-methyl-7-(1-methylethenyl)-; 1-Formyl-7-isopropenyl-4-methylazulene; 1,3,5,7,9,11-Guaiahexaen-15-al; 7-Isopropenyl-4-methyl-1-Azulenecarboxaldehyde. CAS No. 85-33-6. Molecular formula: C15H14O. Mole weight: 210.27.
Macrocarpal A
Macrocarpal A is a cytotoxic alkaloid isolated from the branch of Eucalyptus globulus. Uses: Antifouling activity; antibacterial activity. Synonyms: 2,4,6-Trihydroxy-5-[(1R)-1-[(1aβ,4R,4aβ,7aα,7bβ)-1,1,4,7-tetramethyl-4β-hydroxydecahydro-1H-cyclopropa[e]azulene-7α-yl]-3-methylbutyl]isophthalaldehyde. Grade: 97.5%. CAS No. 132951-90-7. Molecular formula: C28H40O6. Mole weight: 472.6.
Pentione
Pentione is used as a reagent in the synthesis of Guaiazulene (G805000); a lipophilic azulene that is commonly used as a skin conditioning agent in cosmetic, beauty and body care products. It is photomutagenic in Salmonella and also causes DNA damage in human cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 87-45-6. Pack Sizes: 5mg, 25mg. Molecular Formula: C13H20O, Molecular Weight: 192.3. US Biological Life Sciences.
Worldwide
Picrotoxin (Cocculin) 98+%
Picrotoxin is a equimolar mixture of Picrotoxinin and Picrotin. It is a GABAA receptor antagonist and potent CNS stimulant. Group: Biochemicals. Alternative Names: Cocculin; (1aR, 2aR, 3S, 6R, 6aS, 8aS, 8bR, 9S) -Hexahydro-2a-hydroxy-9- (1-hydroxy-1-methylethyl) -8b-methyl-3, 6-methano-8H-1, 5, 7-trioxacyclopenta [ij]cycloprop [a]azulene-4, 8 (3H) -dione compd. with (1aR, 2aR, 3S, 6R, 6aS, 8aS, 8bR, 9R) -hexahydro-2a-hydroxy-8b-methyl-9- (1-methylethenyl) -3, 6-methano-8H-1, 5, 7-trioxacyclopenta [ij]cycloprop [a]azulene-4, 8 (3H) -dione; 3, 6-Methano-8H-1, 5, 7-trioxacyclopenta [ij]cycloprop [a]azulene-4, 8 (3H) -dione, hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-, [1aR-(1aα,2a β,3 β,6 β,6a β,8aS*,8b β,9S*)]-, compd. with [1aR-(1aα,2a β,3 β,6 β,6a β,8aS*,8b β , 9R*) ]-hexahydro-2a-hydroxy-8b-methyl-9- (1-methylethenyl) -3, 6-methano-8H-1, 5, 7-trioxacyclopenta [ij]cycloprop [a]azulene-4, 8 (3H) -dione (1:1); 3, 6-Methano-8H-1, 5, 7-trioxacyclopenta [ij]cycloprop [a]azulene-4, 8 (3H) -dione, hexahydro-2a-hy. Grades: Reagent Grade. CAS No. 124-87-8. Pack Sizes: 1g, 5g. Molecular Formula: C15H18O7·C15H16O6, Molecular Weight: 602.59. US Biological Life Sciences.
Worldwide
PROTAC BRD4 Degrader-11
PROTAC BRD4 Degrader-11 is a PROTAC linked by ligands for von Hippel-Lindau and BRD4. It is conjugated with STEAP1 and CLL1 antibodies to degrade BRD4 protein in PC3 prostate cancer cells with DC50s of 0.23 nM and 0.38 nM, respectively. Synonyms: S-((R)-1-(((((3R,5S)-1-((S)-2-(11-(7-(3,5-difluoropyridin-2-yl)-2-methyl-10-((methylsulfonyl)methyl)-3-oxo-3,4,6,7-tetrahydro-2H-2,4,7-triazadibenzo[cd,f]azulene-9-carboxamido)undecanamido)-3,3-dimethylbutanoyl)-5-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-3-yl)oxy)carbonyl)oxy)propan-2-yl) methanesulfonothioate. Grade: 98%. Molecular formula: C61H75F2N9O12S4. Mole weight: 1292.56.
PROTAC BRD4 Degrader-12
PROTAC BRD4 Degrader-12, a PROTAC connected by ligands for von Hippel-Lindau and BRD4, can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with DC50s of 0.39 and 0.24 nM, respectively. Synonyms: S-(3-(((((3R,5S)-1-((S)-2-(11-(7-(3,5-difluoropyridin-2-yl)-2-methyl-10-((methylsulfonyl)methyl)-3-oxo-3,4,6,7-tetrahydro-2H-2,4,7-triazadibenzo[cd,f]azulene-9-carboxamido)undecanamido)-3,3-dimethylbutanoyl)-5-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-3-yl)oxy)carbonyl)oxy)butan-2-yl) methanesulfonothioate. Grade: 98%. CAS No. 2417370-90-0. Molecular formula: C62H77F2N9O12S4. Mole weight: 1306.58.
Quinocarcin
Quinocarcin is originally isolated from Streptomyces melanovinaceus. It has anti-gram-positive bacteria and Klebsiella pneumoniae activity, and also has anti-mouse leukemia P388 effect. Synonyms: Antibiotic DC 52; DC 52; 11-Methoxy-12-methyl-2a,3,4,5,6,6a,7,11b-octahydro-1H-3,6-epimino-2-oxa-11c-azanaphtho[1,2,3-cd]azulene-5-carboxylic acid; (2aR,3S,5R,6R,6aS,11bR)-2a,3,4,5,6,6a,7,11b-Octahydro-11-methoxy-12-methyl-3,6-imino-1H-2-oxa-11c-azanaphth[1,2,3-cd]azulene-5-carboxylic Acid. CAS No. 84573-33-1. Molecular formula: C18H22N2O4. Mole weight: 330.38.
Tropolone
Tropolone is a seven-membered non-benzenoid aromatic compound, which is the precursor of many Azulene derivatives. Tropolone is a potent mushroom tyrosinase inhibitor with an IC 50 value of 0.4 μM. Its inhibitory effect can be achieved by dialysis or excess CU 2+ Reversa. Tropolone exhibits broad anti-viral and anti-fungal activity and is synergistic upon co-treatment with nucleos(t)ide analog drugs. Tropolone is a promising candidate for research in osteosarcoma [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 533-75-5. Pack Sizes: 10 mM * 1 mL; 1 g. Product ID: HY-N7135.
1,2,3,3a,4,5,6,8a-Octahydro-2-isopropylidene-4,8-dimethylazulen-6-yl propionate. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 1,2,3,3a,4,5,6,8a-octahydro-2-isopropylidene-4,8-dimethylazulen-6-yl propionate;1,2,3,3a,4,5,6,8a-Octahydro-4,8-dimethyl-2-(1-methylethylidene)azulen-6-ol propionate. Product Category: Heterocyclic Organic Compound. CAS No. 10486-26-7. Molecular formula: C18H28O2. Mole weight: 276.41372. Product ID: ACM10486267. Alfa Chemistry ISO 9001:2015 Certified.
(1aS, 3aS, 6aS, 6bS, 7R, 9aR)-7-Hydroxy-1a, 7-dimethyl-4-methyleneoctahydro-1aH-oxireno[2', 3':8, 8a]azuleno[4, 5-b]furan-5(6aH)-one is a reactant in the sysnthesis of Arglabin (A769750), a sesquiterpene lactone used in the inhibition of glucose induced NF-kB activation and MCP-1/TGF- β1 expression treating diabetic nephropathy. Cytocoxic. Group: Biochemicals. Grades: Highly Purified. CAS No. 1343403-10-0. Pack Sizes: 5mg, 50 mg. Molecular Formula: C15H20O4, Molecular Weight: 264.32. US Biological Life Sciences.
2-(2-Deoxy-b-D-ribofuranosyl)-2,3,8,9-tetrahydro-7-oxa-2,3,5,6-tetraazabenz[cd]azulen-4-amine is a compound used as a predecessor in the synthesis of antiviral drugs. It's applied in studying and developing agents that curb diseases like Hepatitis C and HIV due to its nucleoside analog nature. Synonyms: (2R,3S,5R)-5-(6-amino-10-oxa-3,5,7,9-tetrazatricyclo[6.4.1.04,13]trideca-1,4,6,8(13)-tetraen-3-yl)-2-(hydroxymethyl)oxolan-3-ol. CAS No. 477205-38-2. Molecular formula: C13H17N5O4. Mole weight: 307.31.
4-Hydroxy-9-methyl-3,6-dimethylidene-3a,4,5,6a,7,9,9a,9b-octahydroazuleno[4,5-b]furan-2,8-dione. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Grosheimin, Grossheimin, Grosshemin, NSC295425, NSC 295425, CID99967, LS-73186, NCI60_002463, 22489-66-3, 4-beta-H-Guaia-10(14),11(13)-dien-12-oic acid, 6-alpha,8-alpha-dihydroxy-3-oxo-, 12,6-lactone, Azuleno(4,5-b)furan-2,8(3H,4H)-dione, octahydro-4-hydroxy-9-methyl-3,6-bis(methylene)-, (3aR-(3aalpha,4alpha,6aalpha,9alpha,9aalpha,9bbeta))-, 4-.beta.-H-Guaia-10(14),11(13)-dien-12-oic acid, 6-.alpha.,8-.alpha.-dihydroxy-3-oxo-,12,6-lactone. Product Category: Heterocyclic Organic Compound. CAS No. 22489-66-3. Molecular formula: C15H18O4. Mole weight: 262.301 g/mol. Purity: 0.96. IUPACName: 4-hydroxy-9-methyl-3,6-dimethylidene-3a,4,5,6a,7,9,9a,9b-octahydroazuleno[4,5-b]furan-2,8-dione. Canonical SMILES: CC1C2C(CC1=O)C(=C)CC(C3C2OC(=O)C3=C)O. Density: 1.24g/cm³. Product ID: ACM22489663. Alfa Chemistry ISO 9001:2015 Certified.
7,13-Dideacetyl-9,10-didebenzoyltaxchinin C
7,13-Dideacetyl-9,10-didebenzoyltaxchinin C is extracted from the whole plants of Taxus chinensis var. mairei. Synonyms: Decahydro-9a-(1-hydroxy-1-methylethyl)-4a,7-dimethyl-1H-azuleno[5',6':3,4]benz[1,2-b]oxete-4,5,6,8,10,10b(2aH)-hexol 10b-acetate 10-benzoate. Grade: 97.5%. CAS No. 156497-25-5. Molecular formula: C29H38O10. Mole weight: 546.60.
9-Deacetyl-9-benzoyl-10-debenzoyltaxchinin A
9-Deacetyl-9-benzoyl-10-debenzoyltaxchinin A is extracted from the stem barks of Taxus baccata L. cv. stricta. Synonyms: [(2S,4R,5R,5aS,6S,8S,9aR,10S,10aS)-6,10-diacetyloxy-2,4,8-trihydroxy-10a-(2-hydroxypropan-2-yl)-3,5a-dimethyl-9-methylidene-2,4,5,6,7,8,9a,10-octahydro-1H-benzo[g]azulen-5-yl] benzoate. Grade: 97.5%. CAS No. 172486-22-5. Molecular formula: C31H40O10. Mole weight: 572.65.
BET bromodomain inhibitor
A BET bromodomain inhibitor that can be used for the treatment of hematologic malignancies. It binds BET proteins to suppress the interaction between these proteins, propeins and acetylated chromatin, as well as transcription factors. The BET bromodomain inhibitor modulates the expression of oncogenes. Uses: The treatment of hematologic malignancies. Synonyms: MDK3597; MDK-3597; MDK 3597; BET bromodomain inhibitor. 2-[8-Chloro-6-(4-chloro-phenyl)-1-methyl-4H-3-oxa-2,5-diaza-benzo[e]azulen-4-yl]-acetamide. Grade: ≥98%. CAS No. 1505453-59-7. Molecular formula: C20H15Cl2N3O2. Mole weight: 400.259.
Daphnicyclidin D
Daphnicyclidin D is an alkaloid isolated from the stems of Daphniphyllum humile and D.teijsmanni. Synonyms: Daphnicyclidine D; 1,12-Methanopyrano[4',3',2':1,8]azuleno[4,5-a]indolizine-2-carboxylic acid, 3,4,6,7,7a,8,10,11,12,13,13a,13b-dodecahydro-11,13b-dimethyl-14-oxo-, methyl ester, (7aS,9S,11S,12R,13aR,13bS)-. CAS No. 385384-24-7. Molecular formula: C23H27NO4. Mole weight: 381.472.
Daphniyunnine A
Daphniyunnine A is isolated from the leaves and stems of Daphniphyllum macropodum Miq. Synonyms: 1H-11,12c-Methanocyclopent[1,8]azuleno[4,5-a]indolizine-2-carboxylic acid, 2,2a,3,4,5,6,6a,7,9,10,11,12,12a,12b-tetradecahydro-13-oxo-10,12b-dimethyl-, methyl ester, (2R,2aR,6aS,8S,10S,11R,12aR,12bS,12cR)-. Grade: 98%. CAS No. 881388-87-0. Molecular formula: C23H31NO3. Mole weight: 369.5.
Dehydrocostus lactone
Dehydrocostus lactone and CL from root of S. lappa have anti-colorectal cancer activities through inhibiting Wnt/β-catenin pathway. Uses: Anti-colorectal cancer. Synonyms: EPILIGULYL OXIDE; DEHYDROCOSTUSLACTONE; DEHYDROCOSTUS LACTONE hplc; (3aS,6aR,9aR,9bS)-Decahydro-3,6,9-tris(methylene)azuleno[4,5-b]furan-2(3H)-one; DEHYDROCOSTUNOLIDE; Azuleno[4,5-b]furan-2(3H)-one,decahydro-3,6,9-; Costus lactone, dehydro-; tris(methylene)-,(3aS,6aR,9aR,9bS)-. Grade: >98%. CAS No. 477-43-0. Molecular formula: C15H18O2. Mole weight: 230.3.
Helenalin
Helenalin. Uses: Designed for use in research and industrial production. Additional or Alternative Names: HELENALIN;(3as-(3aalpha,4alpha,4abeta,7aalpha,8alpha,9aalpha))-ethyl-3-methylene;[3as]-3,3aalpha,4alpha,4a,7aalpha,8,9,9aalpha-octahydro-4-hydroxy-4abeta,8alph;6alpha,8beta-dihydroxy-4-oxoambrosa-2,11(13)-dien-12-oicacid12,8-lactone;a-dimethyl-3-methyleneazuleno[6,5-b]-furan-2,5-dione;ambrosa-2,11(13)-dien-12-oicacid,6-alpha,8-beta-dihydroxy-4-oxo-,12,8-lacton;ambrosa-2,11(13)-dien-12-oicacid,6alpha,8beta-dihydroxy-4-oxo-,12,8-lactone;azuleno(6,5-b)furan-2,5-dione,3,3a,4,4a,7a,8,9,9a-octahydro-4-hydroxy-4a,8-dim. Product Category: Heterocyclic Organic Compound. Appearance: Powder. CAS No. 6754-13-8. Molecular formula: C15H18O4. Mole weight: 262.3. Purity: 0.98. IUPACName: (3aR,5R,5aR,8aR,9S,9aS)-9-hydroxy-5,8a-dimethyl-1-methylidene-3a,4,5,5a,9,9a-hexahydroazuleno[6,7-b]furan-2,8-dione. Canonical SMILES: CC1CC2C(C(C3(C1C=CC3=O)C)O)C(=C)C(=O)O2. Product ID: ACM6754138. Alfa Chemistry ISO 9001:2015 Certified.
Longistylumphylline A is isolated from the herbs of Daphniphyllum macropodum. Synonyms: Longistylumphylline A; 1H-11,12c-Methanocyclopent[1,8]azuleno[4,5-a]indolizine-2-carboxylic acid, 3,4,5,6,6a,7,9,10,11,12,12a,12b-dodecahydro-10,12b-dimethyl-13-oxo-, methyl ester, (6aR,10R,11S,12aS,12bR,12cS)-rel-(-)-. Grade: 96.5%. CAS No. 857672-34-5. Molecular formula: C23H29NO3. Mole weight: 367.5.
Macrocarpal B
Macrocarpal B, which can be found in the branch of Eucalyptus globulus, shows antifouling activity. Uses: Antibacterial/antifouling. Synonyms: 5-[(1S)-1-[(1aR,4R,4aR,7S,7aS,7bR)-4-hydroxy-1,1,4,7-tetramethyl-1a,2,3,4a,5,6,7a,7b-octahydrocyclopropa[h]azulen-7-yl]-3-methylbutyl]-2,4,6-trihydroxybenzene-1,3-dicarbaldehyde; 1,3-Benzenedicarboxaldehyde, 5-[(1S)-1-[(1aR,4R,4aR,7S,7aS,7bR)-decahydro-4-hydroxy-1,1,4,7-tetramethyl-1H-cycloprop[e]azulen-7-yl]-3-methylbutyl]-2,4,6-trihydroxy-. Grade: >98%. CAS No. 142698-60-0. Molecular formula: C28H40O6. Mole weight: 472.6.
PROTAC BRD4 Degrader-10, a PROTAC connected by ligands for von Hippel-Lindau and BRD4, can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with DC50s of 1.3 and 18 nM, respectively. Synonyms: S-(3-(((((3R,5S)-1-((S)-15-(tert-butyl)-1-(7-(3,5-difluoropyridin-2-yl)-2-methyl-10-((methylsulfonyl)methyl)-3-oxo-3,4,6,7-tetrahydro-2H-2,4,7-triazadibenzo[cd,f]azulen-9-yl)-1,13-dioxo-5,8,11-trioxa-2,14-diazahexadecan-16-oyl)-5-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-3-yl)oxy)carbonyl)oxy)butan-2-yl) methanesulfonothioate. Grade: 98%. CAS No. 2417370-49-9. Molecular formula: C59H71F2N9O15S4. Mole weight: 1312.50.
PROTAC BRD4 Degrader-9
PROTAC BRD4 Degrader-9 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. It can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with DC50 values of 0.86 nM and 7.6 nM, respectively. Synonyms: S-(1-(((((3R,5S)-1-((S)-15-(tert-butyl)-1-(7-(3,5-difluoropyridin-2-yl)-2-methyl-10-((methylsulfonyl)methyl)-3-oxo-3,4,6,7-tetrahydro-2H-2,4,7-triazadibenzo[cd,f]azulen-9-yl)-1,13-dioxo-5,8,11-trioxa-2,14-diazahexadecan-16-oyl)-5-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-3-yl)oxy)carbonyl)oxy)-2-methylpropan-2-yl) methanesulfonothioate. Grade: 98%. CAS No. 2417370-42-2. Molecular formula: C59H71F2N9O15S4. Mole weight: 1312.5.
(S)-GNE-987
(S)-GNE-987, the GNE-987 (a chimeric BET degrader) hydroxy-proline epimer, abrogates binding to von Hippel-Lindau and does not degrade BRD4 protein. It binds to the BRD4 BD1 and BD2 bromodomains with IC50s of 4 and 3.9 nM, respectively. It can be used to design PROTAC-Antibody Conjugate (PAC). Synonyms: N-{11-[({7-(3,5-Difluoro-2-pyridinyl)-2-methyl-10-[(methylsulfonyl)methyl]-3-oxo-3,4,6,7-tetrahydro-2H-2,4,7-triazadibenzo[cd,f]azulen-9-yl}carbonyl)amino]undecanoyl}-3-methyl-L-valyl-(4S)-4-hydroxy-N-[4-(4-methyl-1,3-thiazol-5-yl)benzyl]-L-prolinamide; L-Prolinamide, N-[11-[[[7-(3,5-difluoro-2-pyridinyl)-3,4,6,7-tetrahydro-2-methyl-10-[(methylsulfonyl)methyl]-3-oxo-2H-2,4,7-triazadibenz[cd,f]azulen-9-yl]carbonyl]amino]-1-oxoundecyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4S)-. Molecular formula: C56H67F2N9O8S2. Mole weight: 1096.31.
Spathulenol
Spathulenol is isolated from the herbs of Salvia sclarea. It shows the capacity to inhibit proliferation in the lymphocytes, inducing apoptosis in these cells possibly through a caspase-3 independent pathway. Uses: Immunoinhibitory effect. Synonyms: (1aR,4aR,7S,7aR,7bR)-1,1,7-Trimethyl-4-methylenedecahydro-1H-cyclopropa[e]azulen-7-ol; 10(14)-aromadendren-4-ol. Grade: 95%. CAS No. 6750-60-3. Molecular formula: C15H24O. Mole weight: 220.35.
Taxayunnansin A
Taxayunnansin A is isolated from the barks of Taxus chinensis. Synonyms: (2aR,4S,4aS,5R,6R,8S,9aS,10S,10aR,10bS)-6-(benzoyloxy)-8-hydroxy-9a-(2-hydroxypropan-2-yl)-4a,7-dimethyl-3,4,4a,5,6,8,9,9a,10,10a-decahydro-1H-azuleno[5',6':3,4]benzo[1,2-b]oxete-4,5,10,10b(2aH)-tetrayl tetraacetate. Grade: > 95%. CAS No. 153229-31-3. Molecular formula: C35H44O13. Mole weight: 672.7.
Thapsigargicin
It is a hexaoxygenated tetra-acylated sesquiterpene lactone tetraester isolated from roots of Thapsia garganica. It induces mast cell degranulation and histamine release. Synonyms: Hexanoic acid, (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-buten-1-yl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl ester. Grade: ≥90%. CAS No. 67526-94-7. Molecular formula: C32H46O12. Mole weight: 622.70.
Thapsigargin
A widely used inhibitor of the ubiquitous sarco-endoplasmic reticulum Ca(2+)-ATPases in mammalian cells. It acts as a potent, cell-permeable, IP3-independent intracellular calcium releaser that blocks the transient increase in intracellular Ca2+ induced by angiostatin and endostatin. It induces apoptosis by disrupting intracellular free Ca2+ levels. Group: Biochemicals. Alternative Names: Octanoic Acid (3S, 3aR, 4S, 6S, 6aR, 7S, 8S, 9bS)-6-(Acetyloxy)-2, 3, 3a, 4, 5, 6, 6a, 7, 8, 9b- decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl Ester; (-)-Thapsigargin; Octanoic Acid [3S-[3α,3a β,4α,6 β,6a β,7 β, 8α(Z), 9bα]]-6-(Acetyloxy)-2, 3, 3a, 4, 5, 6, 6a, 7, 8, 9b-decahydro-3, 3a-dihydroxy-3, 6, 9-trimethyl-8-[(2-methyl-1-oxo-2-butenyl)oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4, 5-b]furan-7-yl Ester. Grades: Highly Purified. CAS No. 67526-95-8. Pack Sizes: 2.5mg. US Biological Life Sciences.
Worldwide
Thapsigargin
Thapsigargin, an endoplasmic reticulum (ER) stress inducer, is an inhibitor of microsomal Ca2+-ATPase. Thapsigargin efficiently inhibits coronavirus (HCoV-229E, MERS-CoV, SARS-CoV-2) replication in different cell types. Uses: Designed for use in research and industrial production. Additional or Alternative Names: THAPSIGARGIN;Octanoic acid, (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-buten-1-yl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl ester;(3S,3aR,4S,6S,6AR,7S,8S,9bS)-6-(Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azul. Product Category: Inhibitors. Appearance: liquid or film. CAS No. 67526-95-8. Molecular formula: C34H50O12. Mole weight: 650.75. Purity: 0.95. IUPACName: [(3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-acetyloxy-4-butanoyloxy-3,3a-dihydroxy-3,6,9-trimethyl-8-[(Z)-2-methylbut-2-enoyl]oxy-2-oxo-4,5,6a,7,8,9b-hexahydroazuleno[4,5-b]furan-7-yl]octanoate. Canonical SMILES: CCCCCCCC(=O)OC1C2C(=C(C1OC(=O)C(=CC)C)C)C3C(C(CC2(C)OC(=O)C)OC(=O)CCC)(C(C(=O)O3)(C)O)O. ECNumber: 614-076-3. Product ID: ACM67526958. Alfa Chemistry ISO 9001:2015 Certified.
Vetivert acetate
Vetivert acetate. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Vetiver acetate, Vetivert acetate, Vetiveryl acetate, Vetiverol, acetate, Vetiver acetate, Java, W524301_ALDRICH, EINECS 263-597-9, EINECS 204-225-7, AI3-24214, LS-3152, Vetiveryl acetate (Vetiveria zizanioides (L.) Nash), 1,2,3,3a,4,5,6,8a-Octahydro-2-isopropylidene-4,8-dimethylazulen-6-yl acetate, 6-AZULENOL, 1,2,3,3a,4,5,6,8a-OCTAHYDRO-2-ISOPROPYLIDENE-4,8-DIMETHYL-, ACETATE, 6-Azulenol, 1,2,3,3a,4,5,6,8a-octahydro-4,8-dimethyl-2-(1-methylethylidene)-, acetate, 117-98-6, 62563-80-8. Product Category: Heterocyclic Organic Compound. CAS No. 62563-80-8. Molecular formula: C17H26O2. Mole weight: 262.3871. Purity: N/A. IUPACName: (4,8-dimethyl-2-propan-2-ylidene-3,3a,4,5,6,8a-hexahydro-1H-azulen-6-yl) acetate. Canonical SMILES: CC1CC(C=C(C2C1CC(=C(C)C)C2)C)OC(=O)C. Density: 0.976 g/mL at 25ºC(lit.). ECNumber: 204-225-7. Product ID: ACM62563808. Alfa Chemistry ISO 9001:2015 Certified.
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