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| Product | Description | |
|---|---|---|
| Abemaciclib-[d5] | Labelled Abemaciclib. Abemaciclib is an orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. It is used for the treatment of advanced or metastatic breast cancers. Synonyms: N-[5-[(4-Ethyl-1-piperazinyl)methyl]-2-pyridinyl]-5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-2-pyrimidinamine-d5; N-(5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine-d5. Grades: > 98%. CAS No. 1809251-51-1. Molecular formula: C27H27D5F2N8. Mole weight: 511.62. |  |
| Cairomycin A | Cairomycin A is a peptide antibiotic produced by Streptomyces As-C-19, which has activity against gram-positive bacteria. Synonyms: 3,6-Dioxo-5-isopropyl-2-piperazineacetic acid; 2-Piperazineacetic acid, 5-(1-methylethyl)-3,6-dioxo-, (2S-cis)-; 2-Piperazineacetic acid, 3,6-dioxo-5-isopropyl-, (2S-cis)-. CAS No. 78859-46-8. Molecular formula: C9H14N2O4. Mole weight: 214.22. | |
| Cyclo(D-Ala-Val) | Synonyms: 2,5-Piperazinedione, 3-methyl-6-(1-methylethyl)-, (3R,6S)-; (3S,6R)-3-Isopropyl-6-methyl-2,5-piperazinedione; Cyclo(-D-Ala-Val). Grades: ≥95%. CAS No. 15136-27-3. Molecular formula: C8H14N2O2. Mole weight: 170.21. | |
| GSK2269557 | GSK2269557, an effective PI3K inhibitor, could be used as against inflammatory and some autoimmune diseases. It has just completes a phase II trial against Asthma. Uses: Gsk2269557 is an effective pi3k inhibitor that could be used as against inflammatory and some autoimmune diseases. Synonyms: CHEMBL2216859; GSK2269557 (free base); GSK2269557; GSK-2269557; GSK 2269557; Nemiralisib; 2-(6-(1H-indol-4-yl)-1H-indazol-4-yl)-5-((4-isopropylpiperazin-1-yl)methyl)oxazole; 6-(1H-indol-4-yl)-4-(5-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1H-indazole. Grades: 95%. CAS No. 1254036-71-9. Molecular formula: C26H28N6O. Mole weight: 440.54. | |
| Ipatasertib HCl | Ipatasertib, also known as GDC-0068, is a highly selective pan-Akt inhibitor targeting Akt1/2/3 (IC50= 5 nM/18 nM/8 nM in cell-free assays) with 620-fold selectivity over PKA. Ipatasertib is advancing in clinical development including a Phase 3 trial in patients with prostate cancer and three Phase 2 trials in patients with breast cancer, gastric cancer and prostate cancer. Synonyms: (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one hydrochloride.; GDC0068; GDC-0068; GDC 0068; RG7440; RG-7440; RG 7440; Ipatasertib; Ipatasertib hydrochloride, Ipatasertib HCl. CAS No. 1489263-16-2. Molecular formula: C24H33Cl2N5O2. Mole weight: 494.46. | |
| LP-935509 | LP-935509 is a brain penetrant inhibitor of adapter protein-2 associated kinase 1 (AAK1; IC50 value 3.3 nM and 14 nM and 320 nM for the closely related BIKE and GAK enzymes, repsectively). LP-935509 exhibits antinociceptive property in multiple rat models of neuropathic pain, but not acute pain. The antinociception of AAK1 inhibitor can be blocked by α2 adrenergic antagonists. Uses: Antinociceptive agent. Synonyms: LP935509; LP 935509; LP-935509; Isopropyl 4-(3-(2-methoxypyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)piperazine-1-carboxylate; 4-[3-(2-Methoxy-pyridin-3-yl)-pyrazolo[1,5-a]pyrimidin-5-yl]-piperazine-1-carboxylic acid isopropyl ester. Grades: 99%. CAS No. 1454555-29-3. Molecular formula: C20H24N6O3. Mole weight: 396.44. | |
| Terconazole | Terconazole is an antifungal drug used to treat vaginal yeast infection. It has a relatively broad spectrum compared to azole compounds. It may exert its antifungal activity by disrupting normal fungal cell membrane permeability. It comes as a lotion or a suppository and disrupts the biosynthesis of fats in a yeast cell. It is a suitable compound for prophylaxis for those that suffer from chronic vulvovaginal candidiasis. It has a far greater selectively for yeast cytochrome P-450 than for mammalian microsomal cytochrome P-450. It may also be used in vitro to prevent the morphogenetic transformation of yeast into (pseudo-)mycelium form of Candida albicans. It was developed by Johnson & Johnson and has been listed. Uses: Terconazole is an antifungal drug used to treat vaginal yeast infection. it may also be used in vitro to prevent the morphogenetic transformation of yeast into (pseudo-)mycelium form of candida albicans. Synonyms: Piperazine, 1-[4-[[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-(1-methylethyl)-, cis-; cis-1-(p-{[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)-4-isopropylpiperazine; Piperazine, 1-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-(1-methylethyl)-, rel-; rel-1-[4-[[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-(1-methylethyl)piperazine; (±)-Terconazole; Fungistat; Gyno-Terazol; NSC 331942; R 42470; Terazol; Tercospor; Termayazole; Triaconazole. Grades: 98%. CAS No. 67915-31-5. Molecular formula: C26H31Cl2N5O3. Mole weight: 532.46. | |
| Terconazole Impurity 6 | One impurity of Terbuthylazine, which could be used as a triazine herbicide. Synonyms: 1-ISOPROPYL-4-(4-HYDROXYPHENYL)PIPERAZINE; p-[4-isopropyl-1-piperazinyl]phenol. Grades: > 95%. CAS No. 67914-97-0. Molecular formula: C13H20N2O. Mole weight: 220.32. | |
| TL 13-22 | TL 13-22 is an ALK inhibitor with IC50 value of 0.54 nM. It acts as a negative control for TL 13-22. Synonyms: N- (2- (2- (2- (4- (4- ( (5-Chloro-4- ( (2- (isopropylsulfonyl) phenyl) amino) pyrimidin-2-yl) amino) -3-methoxyphenyl) piperazin-1-yl) ethoxy) ethoxy) ethyl) -2- ( (1, 3-dioxo-2- (2-oxopiperidin-3-yl) isoindolin-4-yl) amino) acetamide. Grades: ≥98% by HPLC. CAS No. 2229036-65-9. Molecular formula: C45H55ClN10O9S. Mole weight: 947.5. | |
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