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| Product | Description | |
|---|---|---|
| c-Met inhibitor 1 | c-Met inhibitor 1 is an inhibitor of the c-Met receptor signaling pathway useful for the treatment of cancer including gastric, glioblastoma, and pancreatic cancer. Synonyms: c-Met inhibitor 1; c Met inhibitor 1. Grades: >98%. CAS No. 1357072-61-7. Molecular formula: C17H14N8S. Mole weight: 362.41. |  |
| c-Met Kinase Inhibitor III | The c-Met Kinase Inhibitor III controls the biological activity of c-Met. Group: Fluorescence/luminescence spectroscopy. |  |
| c-Met/RON Dual Kinase Inhibitor - CAS 913376-84-8 | The c-Met/RON Dual Kinase Inhibitor, also referenced under CAS 913376-84-8, controls the biological activity of c-Met/RON. Group: Fluorescence/luminescence spectroscopy. | |
| 1- β-D-Arabinofuranosyluracil-2-C-methyl | 1- β-D-Arabinofuranosyluracil-2-C-methyl is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro- β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase. Group: Biochemicals. Grades: Highly Purified. CAS No. 114262-49-6. Pack Sizes: 25mg, 250mg. Molecular Formula: C10H14N2O6, Molecular Weight: 258.23. US Biological Life Sciences. |  Worldwide |
| 1- β-D-Arabinofuranosyluracil-2-C-methyl-d3, 13C | 1- β-D-Arabinofuranosyluracil-2-C-methyl-d3, 13C is the labeled analogue of 1- β-D-Arabinofuranosyluracil-2-C-methyl (A764005), an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro- β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase. Group: Biochemicals. Grades: Highly Purified. CAS No. 1256490-38-6. Pack Sizes: 2.5mg, 75mg. Molecular Formula: C913CH11D3N2O6, Molecular Weight: 262.24. US Biological Life Sciences. | Worldwide |
| 1H-Pyrrolo[3,2-b]pyridine-6-carboxylic Acid | 1H-Pyrrolo[3,2-b]pyridine-6-carboxylic Acid is an analog of 4-azaindole and can be used as a novel inhibitor of c-Met kinase. Group: Biochemicals. Grades: Highly Purified. CAS No. 112766-32-2. Pack Sizes: 100mg, 1 g. Molecular Formula: C8H6N2O2, Molecular Weight: 162.15. US Biological Life Sciences. | Worldwide |
| 1-Methyl-4-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyrazol-1-yl]piperidine | 1-Methyl-4-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyrazol-1-yl]piperidine is used in the synthesis of a series of hydroxybenzoxazole derivatives as c-Met kinase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 1323919-64-7. Pack Sizes: 100mg, 1g. Molecular Formula: C15H26BN3O2, Molecular Weight: 291.2. US Biological Life Sciences. | Worldwide |
| 1-Methyl-4-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyrazol-1-yl]piperidine-d3 | 1-Methyl-4-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyrazol-1-yl]piperidine-d3 is the isotope labelled analog of 1-Methyl-4-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyrazol-1-yl]piperidine (M330220); a compound used in the synthesis of a series of hydroxybenzoxazole derivatives as c-Met kinase inhibitors. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 50mg. Molecular Formula: C15H23D3BN3O2, Molecular Weight: 294.22. US Biological Life Sciences. | Worldwide |
| 2',3',5'-Tri-O-benzoyl-2'-C-methyl-5-methoxyuridine | 2',3',5'-Tri-O-benzoyl-2'-C-methyl-5-methoxyuridine, an essential chemical compound in biomedicine research, has been hailed for its remarkable potential antitumor activity and growth inhibitory effects on cancer cells. As scientists continue to explore its possibilities, this versatile compound may also hold the key to treating devastating viral infections like hepatitis C and HIV. Synonyms: 2',3',5'-Tri-O-benzoyl-2'-β-C-methyl-5-methoxyuridine. Grades: ≥95%. CAS No. 2072145-79-8. Molecular formula: C32H28N2O10. Mole weight: 600.57. | |
| 2,3,5-Tri-O-benzoyl-2-C-methyl-D-ribonic acid-1,4-lactone | 2,3,5-Tri-O-benzoyl-2-C-methyl-D-ribonic acid-1,4-lactone is a biochemical reagent used in the development of antiviral drugs, particularly to research of Influenza. It's a precursor in the creation of inhibitors for neuraminidase, an enzyme integral in disease spread. CAS No. 7392-74-7. Molecular formula: C27H22O8. Mole weight: 474.46. | |
| 2,6-Diamino-9-(2-C-methyl-β-D-ribofuranosyl)-9H-purine | 2,6-Diamino-9-(2-C-methyl-β-D-ribofuranosyl)-9H-purine, a potent drug with promising anti-cancer activity, has been extensively employed in the treatment of chronic lymphocytic leukemia and lymphoma. Acting as a potent inhibitor of DNA synthesis, this therapeutic agent promotes apoptosis in malignant cells, effectively retarding tumor growth, and refining patient prognosis. With its proven antimicrobial properties, this efficacious antimetabolite may have the potential to combat various bacterial and viral infections. Synonyms: 2,6-Diaminopurine-9-beta-D-(2'-C-methyl)riboside; 2'-C-Methyl-2-aminoadenosine; (2R,3R,4R,5R)-2-(2,6-diaminopurin-9-yl)-5-(hydroxymethyl)-3-methyl-tetrahydrofuran-3,4-diol; 2-Amino-2'-C-methyladenosine. Grades: ≥95%. CAS No. 640725-73-1. Molecular formula: C11H16N6O4. Mole weight: 296.28. | |
| 2-Amino-6-chloro-9-(2-C-methyl-β-D-ribofuranosyl)-9H-purine | 2-Amino-6-chloro-9-(2-C-methyl-β-D-ribofuranosyl)-9H-purine possesses unique chemical properties that are invaluable in studying nucleic acid metabolism and viral pathogenesis. Additionally, this important pharmaceutical intermediate stands out as a potent inhibitor of viral DNA and RNA replication and hits the mark in blocking the synthesis of cancer cells. Its multifaceted applications extend to the treatment of viral infections, including hepatitis B and C, and oncology. Synonyms: 6-Chloro-9-(2-C-methyl-beta-D-ribofuranosyl)-9H-purin-2-amine; 2-Amino-6-chloro-9-(2-C-methyl-β-D-ribofuranosyl)purine; (2R,3R,4R,5R)-2-(2-amino-6-chloro-9H-purin-9-yl)-5-(hydroxymethyl)-3-methyltetrahydrofuran-3,4-diol; (2R,3R,4R,5R)-2-(2-Amino-6-chloro-purin-9-yl)-5-(hydroxymethyl)-3-methyl-tetrahydrofuran-3,4-diol. Grades: ≥95%. CAS No. 640725-74-2. Molecular formula: C11H14ClN5O4. Mole weight: 315.71. | |
| 2-?Azido-3,5-di-O-benzoyl-?2-?deoxy-?2-?C-?methyl-D-?ribonic acid g-?lactone | 2-Azido-3,5-di-O-benzoyl-2-deoxy-2-C-methyl-D-ribonic acid g-lactone, a paramount compound extensively employed in the biomedical sector, showcases its indispensability. It serves as a primordial constituent in the production of prospective antiviral substances, with specific emphasis on HIV and herpes simplex viruses. Its extraordinary chemical composition bestows it with commendable inhibitory properties against viral replication, thus rendering it an invaluable asset in the realm of antiviral pharmaceutical advancement and scholarly investigation. Synonyms: SB15611; 1403574-26-4; (2R,3S,4R)-4-azido-2-[(benzoyloxy)methyl]-4-methyl-5-oxooxolan-3-yl benzoate. CAS No. 1403574-26-4. Molecular formula: C20H17N3O6. Mole weight: 395.37. | |
| 2'-b-C-Methyl-2-amino-N6,N6-dimethyladenosine | 2'-b-C-Methyl-2-amino-N6,N6-dimethyladenosine, a potent and selective inhibitor of adenosine transporters with potential anti-inflammatory and anti-cancer effects, has demonstrated effectiveness in treating certain types of leukemia and lymphoma by disrupting cancer cell proliferation. Its applications also extend to regulating immune function and treating autoimmune diseases. Synonyms: (2R,3R,4R,5R)-2-(2-Amino-6-(dimethylamino)-9H-purin-9-yl)-5-(hydroxymethyl)-3-methyltetrahydrofuran-3,4-diol; 2'-β-C-Methyl-2-amino-N6,N6-dimethyladenosine; 2-Amino-N,N-dimethyl-2'-C-methyladenosine. Grades: ≥95%. CAS No. 1336975-57-5. Molecular formula: C13H20N6O4. Mole weight: 324.34. | |
| 2'-c-Methyladenosine | 2'-C-Methyladenosine is an inhibitor of hepatitis C virus (HCV) replication. 2'-C-Methyladenosine inhibits HCV replicon and NS5B-catalyzed RNA synthesis with IC50 values of 0.3μM and 1.9 μM, respectively. 2'-C-Methyladenosine also potently inhibits LRV1 in Leishmania guyanensis (Lgy) and Leishmania braziliensis. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: Solid. CAS No. 15397-12-3. Molecular formula: C11H15N5O4. Mole weight: 281.27. Purity: 0.9963. Canonical SMILES: OC[C@@H]1[C@@H](O)[C@@](C)(O)[C@H](N2C3=NC=NC(N)=C3N=C2)O1. Product ID: ACM15397123. Alfa Chemistry ISO 9001:2015 Certified. |  |
| 2'-C-Methyladenosine | 2'-C-Methyladenosine is an inhibitor of hepatitis C virus (HCV) replication (IC50 = 0.3 μM in Huh-7 human hepatoma cells) that is not cytotoxic at concentrations up to 100 μM. Synonyms: 2-CMA; (2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)-3-methyltetrahydrofuran-3,4-diol; 6-Amino-9-(2'-C-methyl-b-D-ribofuranosyl)purine. Grades: ≥95%. CAS No. 15397-12-3. Molecular formula: C11H15N5O4. Mole weight: 281.27. | |
| 2'-C-Methyluridine | A2'-C-Me branched C-nucleoside that shows HCV polymerase inhibitory activity. Synonyms: 2'-C-Methyl-1-β-D-ribofuranosyluracil; 1-((2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; 2'-Methyl Uridine; 1,3-bis(N-cyclohexyl)guanidine; 1-(2-C-Methyl-β-D-ribofuranosyl)uracil; 2,4(1H,3H)-pyrimidinedione, 1-(2-C-methyl-β-D-ribofuranosyl)-. Grades: ≥95%. CAS No. 31448-54-1. Molecular formula: C10H14N2O6. Mole weight: 258.23. | |
| 2'-C-Methyluridine-5'-phosphoramidate Triethylamine Salt | 2'-C-Methyluridine-5'-phosphoramidate (TEA Salt) is the analog of 2'-C-Methyluridine, A 2'-C-Me branched C-nucleoside that shows HCV polymerase inhibitory activity. Synonyms: 1,3-bis(N-cyclohexyl)guanine Salt. Molecular formula: C18H36N4O8P. Mole weight: 467.47. | |
| 2-Keto Crizotinib | 2-Keto Crizotinib is an impurity of Crizotinib, a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). Crizotinib is a potential antitumor agent. Synonyms: 4-[4-[6-Amino-5-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-3-pyridinyl]-1H-pyrazol-1-yl]-2-piperidinone. Grades: > 95%. CAS No. 1415558-82-5. Molecular formula: C21H20Cl2FN5O2. Mole weight: 464.32. | |
| 2-?Nitro-?4'-?chlorodiphenylamine | 2-?Nitro-?4'-?chlorodiphenylamine is a reagent used in the synthesis of novel 4-phenoxyquinoline derivatives as c-Met kinase inhibitors. Intermediate for Clofazimine. Group: Biochemicals. Grades: Highly Purified. CAS No. 23008-56-2. Pack Sizes: 1g, 5g. Molecular Formula: C12H9ClN2O2, Molecular Weight: 248.67. US Biological Life Sciences. | Worldwide |
| (2'R)-2'-deoxy-2'-fluoro-2'-C-methyluridine | PSI-6206 is a selective HCV RNA polymerase inhibitor. It is the unphosphorylated parent compound of triphosphate analog PSI-7409, which is a potent inhibitor of the HCV NS5B RNA dependent RNA polymerase. Synonyms: RO-2433; RO 2433; RO2433; PSI6206; PSI 6206; PSI-6206; GS331007; GS-331007; GS 331007; 2'-Deoxy-2'-fluoro-2'-C-methyluridine; Sofosbuvir Metabolite GS331007; 1-((2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione. Grades: ≥95%. CAS No. 863329-66-2. Molecular formula: C10H13FN2O5. Mole weight: 260.22. | |
| (2R)-2-Deoxy-2-fluoro-2-methyl- β-D-erythro-pentofuranose 3,5-Dibenzoate | (2R)-2-Deoxy-2-fluoro-2-methyl- β-D-erythro-pentofuranose 3,5-Dibenzoate has been employed in a study to investigate potent inhibitors against CD38 NADase, an enzyme involved with the metabolism of nicotinamide and calcium signalling pathway. It also has utility in the stereoselective synthesis of β-D-2'-Deoxy-2'-α-fluoro-2'- β-C-methyl-3',5'-cyclic phosphate nucleotide, a prodrug for treating hepatitis C virus (HCV) infection. Group: Biochemicals. Grades: Highly Purified. CAS No. 1199809-22-7. Pack Sizes: 50mg, 100mg. Molecular Formula: C20H19FO6, Molecular Weight: 374.36. US Biological Life Sciences. | Worldwide |
| (2R)-2-Deoxy-2-fluoro-2-methyl-D-erythropentonic Acid γ-Lactone 3,5-Dibenzoate | (2R)-2-Deoxy-2-fluoro-2-methyl-D-erythropentonic Acid γ-Lactone 3,5-Dibenzoate is a reactant used in the synthesis of 1'-C-cyano-2'-fluoro-2'-C-methyl pyrimidine nucleosides as HCV polymerase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 874638-80-9. Pack Sizes: 1g, 5g. Molecular Formula: C20H17FO6, Molecular Weight: 372.34. US Biological Life Sciences. | Worldwide |
| (2'R) -2'-Deoxy-3', 5'-bis-O-[ (1, 1-dimethylethyl) dimethylsilyl]-2'-fluoro-2'-methyl-uridine | (2'R) -2'-Deoxy-3', 5'-bis-O-[ (1, 1-dimethylethyl) dimethylsilyl]-2'-fluoro-2'-methyl-uridine is an intermediate in the synthesis of Sofosbuvir (R)-Phosphate (S675615), which is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro- β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase. Group: Biochemicals. Grades: Highly Purified. CAS No. 1393526-40-3. Pack Sizes: 10mg, 25mg. Molecular Formula: C22H41FN2O5Si2. US Biological Life Sciences. | Worldwide |
| (2'R) -2'-Deoxy-3'-O-[ (1, 1-dimethylethyl) dimethylsilyl]-2'-fluoro-2'-methyl-uridine | (2'R) -2'-Deoxy-3'-O-[ (1, 1-dimethylethyl) dimethylsilyl]-2'-fluoro-2'-methyl-uridine is an intermediate in the synthesis of Sofosbuvir (R)-Phosphate (S675615), which is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro- β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase. Group: Biochemicals. Grades: Highly Purified. CAS No. 1244762-86-4. Pack Sizes: 5mg, 10mg. Molecular Formula: C16H27FN2O5Si. US Biological Life Sciences. | Worldwide |
| 2- (Trifluoromethoxy) benzonitrile | 2- (Trifluoromethoxy) benzonitrile is used for the synthesis of 4- (2-fluorophenoxy) quinoline derivatives as selective c-Met inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 63968-85-4. Pack Sizes: 5g, 10g. Molecular Formula: C8H4F3NO, Molecular Weight: 187.12. US Biological Life Sciences. | Worldwide |
| 3'-Deoxy-3'-a-C-methyl-N6-dimethyladenosine | 3'-Deoxy-3'-a-C-methyl-N6-dimethyladenosine is a highly potent and selectively targeted inhibitor, finding its indispensable utility within the expansive biomedical realm for the probing and unraveling of intricate RNA molecule modifications. When employed with precision, this compound demonstrates exceptional efficacy in delving into the multifaceted intricacies of N6-methyladenosine (m6A) methylation, thereby unraveling the elusive machinations governing cellular processes, gene expression, and the underlying mechanisms of afflictions spanning from cancer to neurological disorders. Synonyms: 3'-Deoxy-3'-a-C-methyl-N6,N6-dimethyladenosine; 3'-Deoxy-3'-α-C-methyl-N6-dimethyladenosine. Grades: ≥95%. CAS No. 2095417-44-8. Molecular formula: C13H19N5O3. Mole weight: 293.32. | |
| 3'-O-Benzyl Sofosbuvir Desphosphate | 3'-O-Benzyl Sofosbuvir Desphosphate may be a metabolite of Sofosbuvir, a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase. Synonyms: 1-((2R,3R,4R,5R)-4-(Benzyloxy)-3-fluoro-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione. Molecular formula: C17H19FN2O5. Mole weight: 350.34. | |
| 4'-Methylthymidine | It shows inhibitory activity against HIV in MT-4 cells. Synonyms: 4'-c-methylthymidine; 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-5-methyl-tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione; 1-(2-Deoxy-4-C-methyl-β-D-erythro-pentofuranosyl)thymine. Grades: ≥95%. CAS No. 139925-84-1. Molecular formula: C11H16N2O5. Mole weight: 256.26. | |
| 5-Fluoro-3'-beta-C-methyluridine | 5-Fluoro-3'-beta-C-methyluridine is an immensely powerful antiviral entity, exhibiting inhibitory efficacy against select RNA viruses, notably hepatitis C virus and Zika virus. Focusing on its modus operandi, it exerts its effects by markedly impeding theenhancement and replication of viral RNA. Synonyms: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-4-methyloxolan-2-yl]-5-fluoropyrimidine-2,4-dione; 5-Fluoro-3'-C-methyluridine. Grades: ≥95%. Molecular formula: C10H13FN2O6. Mole weight: 276.22. | |
| 5'(R)-C-Methyl-3-deazauridine | 5'(R)-C-Methyl-3-deazauridine, a formidable antiviral and anticancer compound widely applied in the biomedical sector, exerts remarkable inhibitory effects on RNA virus proliferation. Its efficacy extends to combating herpes simplex and hepatitis C viruses. Synonyms: 4-Hydroxy-1-(5(R)-C-methyl)-beta-D-ribofuranosyl-2(1H)-pyridinone. Grades: ≥95%. CAS No. 2305415-82-9. Molecular formula: C11H15NO6. Mole weight: 257.24. | |
| 5'(R)-C-Methyl-5-fluorouridine | 5'(R)-C-Methyl-5-fluorouridine is an impactful antiviral nucleoside analog extensively utilized within the biomedical realm, showcasing remarkable selectivity in its cytotoxicity towards specific cancer cells. Its pivotal role lies in research of diverse viral infections, exemplified by its utilization in hepatitis C. This remarkable compound impeccably assumes the capacity of a nucleoside reverse transcriptase inhibitor, effectively hindering viral replication and, thereby, facilitating the mitigating of viral ailments. Synonyms: 5'-C-Methyl-5-fluorouridine. Grades: ≥95%. Molecular formula: C10H13FN2O6. Mole weight: 276.22. | |
| 7-(2-C-Methyl-b-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine | 7-(2-C-Methyl-b-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine, an intricate compound of paramount significance, finds extensive application in the biomedical sector for combating diverse viral infections. It unveils remarkable inhibitory potential against particular viruses through its precise engagement with vital viral enzymes or proteins, thereby impeding the replication and dissemination of the pathogens. Synonyms: (2R,3R,4R,5R)-2-(2-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol;443642-48-6;SCHEMBL731577;ZHRLTTOGZNAIAQ-FWSPBBIJSA-N;ZINC34003523;NU000308. Grades: 95%. CAS No. 443642-48-6. Molecular formula: C12H16N4O4. Mole weight: 280.28. | |
| 7-Deaza-2'-C-methyladenosine | 7-Deaza-2'-C-methyladenosine is a hepatitis C virus (HCV) polymerase inhibitor. Uses: Hepatitis c virus (hcv) polymerase inhibitor. Synonyms: 2'-b-C-methyltubercidin; MK-0608; MK 608; 7-deaza-2'-C-methyladenosine; 7-DMA; (2R,?3R,?4R,?5R)?-2-(4-Amino-7H-pyrrolo[2,?3-d]?pyrimidin-7-yl)?-5-(hydroxymethyl)?-3-methyltetrahydrofura?n-3,?4-diol; 7-(2-C-Methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine. Grades: ≥95%. CAS No. 443642-29-3. Molecular formula: C12H16N4O4. Mole weight: 280.28. | |
| 9-(2-C-Methyl-b-D-ribofuranosyl)purine | 9-(2-C-Methyl-b-D-ribofuranosyl)purine is a formidable nucleoside analogrenowned for its unwavering antiviral prowess. This exceptional compound operates as a potent nucleoside reverse transcriptase inhibitor, skillfully impeding viral replication via the artful blockade of the reverse transcriptase enzyme. Synonyms: 9-(2-C-Methyl-β-D-ribofuranosyl)purine; 9H-Purine, 9-(2-C-methyl-beta-D-ribofuranosyl)-; (2R,3R,4R,5R)-5-(Hydroxymethyl)-3-methyl-2-(9H-purin-9-yl)tetrahydrofuran-3,4-diol; 9-(2-C-Methyl-β-D-ribofuranosyl)-9H-purine. Grades: ≥95%. CAS No. 690269-86-4. Molecular formula: C11H14N4O4. Mole weight: 266.25. | |
| ABN401 | ABN401 is an orally active and selective ATP-competitive c-MET inhibitor with an IC 50 of 10 nM. ABN401 is cytotoxic to MET-addicted cancer cells with the IC 50 of 2-43 nM. ABN401 has bioavailability in rats and dogs of 42.1-56.2% and 27.4-37.7%, respectively. ABN401 has antitumor activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2242563-15-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147040. |  |
| Altiratinib | Altiratinib, also known as DCC-270, DP-5164, is an oral, selective and highly potent inhibitor of MET, TIE2, VEGFR2 and TRK kinases with potential anticancer activity. DCC-2701 effectively reduces tumor burden in vivo and blocks c-MET pTyr(1349)-mediated signaling, cell growth and migration as compared with a HGF antagonist in vitro. Importantly, DCC-2701's anti-proliferative activity was dependent on c-MET activation induced by stromal human fibroblasts and to a lesser extent exogenous HGF. DCC-2701 may be superior to HGF antagonists that are in clinical trials and that pTyr(1349) levels might be a good indicator of c-MET activation and likely response to targeted therapy as a result of signals from the microenvironment. Synonyms: DCC2701; DCC 2701; DCC-2701; DP 5164; DP5164; DP-5164; Altiratinib. Grades: >98%. CAS No. 1345847-93-9. Molecular formula: C26H21F3N4O4. Mole weight: 510.46. | |
| Altromycin A | It is produced by the strain of Actinomycetes AB 1246E-26. It has anti-Gram-positive bacteria activity, and the MIC for Streptococcus and Staphylococcus is between 0.2-3.12ug/mL. It also has an inhibitory effect on a variety of tumor cells. Synonyms: methyl 2-(3,5-dihydroxy-4-methoxy-6-methyltetrahydro-2H-pyran-2-yl)-2-(2-(2,3-dimethyloxiran-2-yl)-11-hydroxy-10-(5-((5-hydroxy-4-methoxy-6-methyltetrahydro-2H-pyran-3-yl)oxy)-4,6-dimethyl-4-(methylamino)tetrahydro-2H-pyran-2-yl)-4,7,12-trioxo-7,12-dihydro-4H-naphtho[2,3-h]chromen-5-yl)-2-hydroxyacetate; D-glycero-D-manno-Octonicacid,3,7-anhydro-8-deoxy-2-C-[2-(2,3-dimethyloxiranyl)-7,12-dihydro-11-hydroxy-4,7,12-trioxo-10-[2,3,6-trideoxy-4-O-(2,6-dideoxy-3-O-methyl-a-D-ribo-hexopyranosyl)-3-C-methyl-3-(methylamino)-a-L-lyxo-hexopyranosyl]-4H-anthra[1,2-b]pyran-5-yl]-5-O-methyl-,methyl ester, (2x)-(9CI); 4H-Anthra[1,2-b]pyran, D-glycero-D-manno-octonic acid deriv. Grades: 95%. CAS No. 128439-47-4. Molecular formula: C46H57NO18. Mole weight: 911.94. | |
| Altromycin B | It is produced by the strain of Actinomycetes AB 1246E-26. It has anti-Gram-positive bacteria activity, and the MIC for Streptococcus and Staphylococcus is between 0.2-3.12ug/mL. It also has an inhibitory effect on a variety of tumor cells. Synonyms: GTPL10964; Octonic acid, 3,7-anhydro-8-deoxy-2-C-(2-(2,3-dimethyloxiranyl)-7,12-dihydro-11-hydroxy-4,7,12-trioxo-10-(2,3,6-trideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-D-ribo-hexopyranosyl)-3-(dimethylamino)-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-4H-anthra(1,2-b)pyran-5-yl)-5-O-methyl-, methyl ester; 4H-Anthra[1,2-b]pyran,D-glycero-D-manno-octonic acid deriv.; D-glycero-D-manno-Octonicacid,3,7-anhydro-8-deoxy-2-C-[2-(2,3-dimethyloxiranyl)-7,12-dihydro-11-hydroxy-4,7,12-trioxo-10-[2,3,6-trideoxy-4-O-(2,6-dideoxy-3-O-methyl-a-D-ribo-hexopyranosyl)-3-(dimethylamino)-3-C-methyl-a-L-lyxo-hexopyranosyl]-4H-anthra[1,2-b]pyran-5-yl]-5-O-methyl-,methyl ester, (2x)-. Grades: 95%. CAS No. 128461-00-7. Molecular formula: C47H59NO18. Mole weight: 925.96. | |
| AMG208 | AMG 208 is a selective small-molecule inhibitor of the proto-oncogene c-Met with potential antineoplastic activity. C-Met encodes the hepatocyte growth factor receptor tyrosine kinase, plays an important role in epithelial cell proliferation and has been shown to be overexpressed in a variety of cancers. Synonyms: AMG-208; AMG208; AMG 208. Grades: 0.98. CAS No. 1002304-34-8. Molecular formula: C22H17N5O2. Mole weight: 383.411. | |
| AMG-337 | AMG 337 is an orally bioavailable inhibitor of the proto-oncogene c-Met with potential antineoplastic activity. c-Met inhibitor AMG 337 selectively binds to c-Met, thereby disrupting c-Met signal transduction pathways. Synonyms: AMG337; AMG-337; AMG 337. Grades: 98%. CAS No. 1173699-31-4. Molecular formula: C23H22FN7O3. Mole weight: 463.47. | |
| AMG-458 | AMG 458 is a potent c-Met inhibitor with Ki of 1 nM ~ 2.0 nM. AMG-458 was found to significantly inhibit tumor growth in the NIH3T3/TPR-Met and U-87 MG xenograft models with no adverse effect on body weight. Synonyms: AMG458; AMG 458; 1-(2-Hydroxy-2-methylpropyl)-N-[5-[(7-methoxyquinolin-4-yl)oxy]pyridin-2-yl]-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide; 2,3-Dihydro-1-(2-hydroxy-2-methylpropyl)-N-[5-[(7-methoxy-4-quinolinyl)oxy]-2-pyridinyl]-5-methyl-3-oxo-2-phenyl-1H-pyrazole-4-carboxamide. Grades: ≥98%. CAS No. 913376-83-7. Molecular formula: C30H29N5O5. Mole weight: 539.58. | |
| BMS 777607 | BMS 777607 (BMS 817378) is a Met-related inhibitor for c-Met , Axl , Ron and Tyro3 with IC 50 s of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM, respectively, and 40-fold more selective for Met-related targets than Lck, VEGFR-2, and TrkA/B, with more than 500-fold greater selectivity versus all other receptor and non receptor kinases [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS 817378. CAS No. 1025720-94-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12076. | |
| BMS-986094 | BMS-986094 (INX-08189) is a potent inhibitor of hepatitis C virus (HCV) replication, with an EC 50 of 35 nM at 24 h in Huh-7 cells. BMS-986094 is a phosphoramidate proagent of 6-O-methyl-2-C-methyl guanosine. BMS-986094 can be used for the research of chronic HCV infection [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: INX-08189. CAS No. 1234490-83-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13337. | |
| BPI-9016M | BPI-9016M is a potent, orally active, and selective dual c-Met and AXL tyrosine kinases inhibitor. BPI-9016M suppresses tumor cell growth, migration and invasion of lung adenocarcinoma [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1528546-94-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114356. | |
| Cabozantinib | Cabozantinib is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively. Grades: >98%. CAS No. 849217-68-1. Molecular formula: C28H24FN3O5. Mole weight: 501.51. | |
| Cabozantinib Des-O-fluoroaniline | It is an impurity of Cabozantinib. Cabozantinib is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively. Synonyms: 1-((4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)carbamoyl)cyclopropane-1-carboxylic acid; Cabozantinib Impurity 03. CAS No. 849217-77-2. Molecular formula: C22H20N2O6. Mole weight: 408.40. | |
| Cabozantinib, Free Base, 99+% | Cabozantinib, also known as XL184, is an orally bioavailable novel tysosine kinase inhibitor of c-MET and VEGF receptor 2 (VEGFR2). It inhibited MET and VEGFR2 with IC50 values of 1.3 nM and 35 pM, respectively. It also inhibited MET-activating kinase domain mutations Y1248H, D1246N, or K1262R with IC50 values of 3.8, 11.8, and 14.6 nM, respectively. It strongly inhibited several kinases that are implicated in tumor pathobiology including KIT, RET, AXL, TIE2, and FLT3 with IC50 values of 4.6, 5.2, 7, 14.3, and 11.3 nM, respectively. In cellular assays, cabozantinib inhibited phosphorylation of MET, VEGFR2, KIT, FLT3, and AXL with IC50 values of 7.8, 1.9, 5.0, 7.5, and 42 [micro]M, respectively. Cabozantinib inhibited tumor angiogenesis, tumor growth and metastasis in cancers with dysregulated MET and VEGFR signaling. Yakes F.M., et al "Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth." Mol. Cancer Ther. 10: 229 Group: Biochemicals. Alternative Names: BMS-907351; XL-184; Cometriq; N- [4- [ (6, 7-Dimethoxy-4-quinolinyl) oxy] phenyl] -N- (4-fluorophenyl) -1, 1-cyclopropane dicarboxamide (2S)-2-Hydroxybutanedioic Acid. Grades: Highly Purified. CAS No. 849217-68-1. Pack Sizes: 25mg, 50mg, 100mg. US Biological Life Sciences. | Worldwide |
| Cabozantinib L-Malate Salt | Cabozantinib is a small molecule C-Met modulator. Cabozantinib acts as a potent multitargeted VEGFR2, Met, FLT3, Tie2, Kit and Ret inhibitor with IC50 of 0.035, 1.8, 14.4, 14.3 and 4.6 nM for VEGFR2, Met, FLT3, Tie2 and Kit, respectively. Cabozantinib shows dose-dependent inhibition of tumor growth and tumor regression, associated with disruption of the tumor vasculature and extensive tumor cell apoptosis. Group: Biochemicals. Alternative Names: N- [4- [ (6, 7-Dimethoxy-4-quinolinyl) oxy] phenyl] -N- (4-fluorophenyl) -1, 1-cyclopropane dicarboxamide (2S)-2-Hydroxybutanedioic Acid; Cabozantinib S-Malate; BMS-907351; XL-184; Cometriq. Grades: Highly Purified. CAS No. 849217-68-1. Pack Sizes: 25mg, 50mg, 100mg. US Biological Life Sciences. | Worldwide |
| Cabozantinib N-oxide | It is an impurity of Cabozantinib. Cabozantinib is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively. Synonyms: 4-(4-(1-((4-fluorophenyl)carbamoyl)cyclopropane-1-carboxamido)phenoxy)-6,7-dimethoxyquinoline 1-oxide; 1,1-Cyclopropanedicarboxamide, N-(4-((6,7-dimethoxy-1-oxido-4-quinolinyl)oxy)phenyl)-N'-(4-fluorophenyl)-; Cabozantinib Impurity 04. CAS No. 1621681-63-7. Molecular formula: C28H24FN3O6. Mole weight: 517.51. | |
| Cabozantinib S-malate | Cabozantinib malate is the malate of Cabozantinib, a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively. Synonyms: Cabozantinib malate; cabozantinib (S)-malate; Cabometyx; 1-N-[4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-1-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (2S)-2-hydroxybutanedioic acid. Grades: >98%. CAS No. 1140909-48-3. Molecular formula: C28H24FN3O5.C4H6O5. Mole weight: 635.59. | |
| Cabozantinib S-malate | Cabozantinib S-malate (XL184 S-malate) is a potent multiple receptor tyrosine kinases inhibitor that inhibits VEGFR2 , c-Met , Kit , Axl and Flt3 with IC 50 s of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: XL184 S-malate; BMS-907351 S-malate. CAS No. 1140909-48-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-12044. | |
| Capmatinib | Capmatinib, also known as INCB28060 and INC280, is an orally bioavailable inhibitor of the proto-oncogene c-Met (hepatocyte growth factor receptor [HGFR]) with potential antineoplastic activity. It selectively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays key roles in tumor cell proliferation, survival, invasion, metastasis, and tumor angiogenesis. It has been granted Breakthrough Therapy Designation by FDA as a first-line treatment for patients with metastatic MET exon14 skipping-mutated non-small cell lung cancer (NSCLC). Synonyms: INCB28060; INC-280; INC280. CAS No. 1029712-80-8. Molecular formula: C23H17FN6O. Mole weight: 412.43. | |
| Capmatinib | Capmatinib (INC280; INCB28060) is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor ( IC 50 =0.13 nM). Capmatinib can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis. Antitumor activity. Capmatinib is largely metabolized by CYP3A4 and aldehyde oxidase [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: INC280; INCB28060. CAS No. 1029712-80-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-13404. | |
| Capmatinib dihydrochloride hydrate | Capmatinib (INC280; INCB28060) dihydrochloride hydrate is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor ( IC 50 =0.13 nM). Capmatinib dihydrochloride hydrate can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib dihydrochloride hydrate potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis. Antitumor activity. Capmatinib dihydrochloride hydrate is largely metabolized by CYP3A4 and aldehyde oxidase [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: INC280 dihydrochloride hydrate; INCB-28060 dihydrochloride hydrate. CAS No. 1865733-40-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13404C. | |
| Capmatinib hydrochloride | Capmatinib (INC280; INCB28060) hydrochloride is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor ( IC 50 =0.13 nM). Capmatinib hydrochloride can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib hydrochloride potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis. Antitumor activity. Capmatinib hydrochloride is largely metabolized by CYP3A4 and aldehyde oxidase [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: INC280 hydrochloride; INCB-28060 hydrochloride. CAS No. 1029714-89-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13404B. | |
| CEP-40783 | CEP-40783 is an orally-active, nanomolar potent and highly kinase-selective Type II inhibitor of the AXL and c-Met RTK with IC50 values of 7 nM and 12 nM, respectively. Synonyms: N-[4-(6,7-dimethoxyquinolin-4-yl)oxy-3-fluorophenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide; CEP40783; CEP 40783; CEP-40783; RXDX-106; RXDX 106; RXDX106. CAS No. 1437321-24-8. Molecular formula: C31H26F2N4O6. Mole weight: 588.56. | |
| CEP-40783 | CEP-40783 is a potent, selective and orally available inhibitor of AXL and c-Met with IC50 values of 7 nM and 12 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RXDX-106. CAS No. 1437321-24-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-100946. | |
| Chloro Sofosbuvir | Chloro Sofosbuvir is an impurity of Sofosbuvir; a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled Sofosbuvir as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase. Synonyms: N-[[P(S),2'R]-2'-Chloro-2'-deoxy-2'-methyl-P-phenyl-5'-uridylyl]-L-alanine 1-Methylethyl Ester. Grades: ≥98% (HPLC). CAS No. 1496552-51-2. Molecular formula: C22H29ClN3O9P. Mole weight: 545.91. | |
| Chrysomycin a | Chrysomycin A (Chr-A), an antibiotic, can be obtained from Streptomyces. Chrysomycin A exhibits antitumor and anti-tuberculous and MRSA activities. As for glioblastoma, Chrysomycin A inhibits the proliferation, migration, and invasion of cancer cells through the Akt/GSK-3β/β-catenin signaling pathway. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Albacarcin V, MLS002701849, NSC354844, 1,5-anhydro-6-deoxy-1-(8-ethenyl-1-hydroxy-10,12-dimethoxy-6-oxo-6h-dibenzo[c,h]chromen-4-yl)-3-c-methylhexitol, 82196-88-1, VIRENOMYCIN V, AC1Q6MMD, AC1L3VB3, KST-1B9536, AR-1B8017, NSC613946, NSC 354844, NSC-354844, NSC-613946, NCI60_003193, SMR001565441, 4-(6-Deoxy-3-C-methyl-.beta.-gulopyranosyl)-8-vinyl-1-hydroxy-10,12-dimethoxy-6H-benzo[d]naphtho[1,2-b]. Product Category: Inhibitors. CAS No. 82196-88-1. Molecular formula: C28H28O9. Mole weight: 508.52. Purity: 0.96. IUPACName: 8-ethenyl-1-hydroxy-10,12-dimethoxy-4-(3,4,5-trihydroxy-4,6-dimethyloxan-2-yl)naphtho[1,2-c]isochromen-6-one. Canonical SMILES: CC1C(C(C(C(O1)C2=C3C(=C(C=C2)O)C(=CC4=C3OC(=O)C5=CC(=CC(=C54)OC)C=C)OC)O)(C)O)O. Density: 1.405g/cm³. Product ID: ACM82196881. Alfa Chemistry ISO 9001:2015 Certified. Categories: Chrysomyinae. | |
| Crizotinib | Crizotinib is a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). Crizotinib is a potential antitumor agent. Group: Biochemicals. Alternative Names: 3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine; (R)-3-[1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H- pyrazol-4-yl)pyridin-2-ylamine; PF 02341066; PF 2341066; [3-[[ (R) -1- (2, 6-Dichloro-3-fluorophenyl) ethyl]oxy]-5-[1- (piperidin-4-yl) -1H-pyrazol-4-yl]pyridin-2-yl]amine. Grades: Highly Purified. CAS No. 877399-52-5. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Crizotinib | Crizotinib (PF-02341066) is an orally bioavailable, ATP-competitive ALK and c-Met inhibitor with IC 50 s of 20 and 8 nM, respectively. Crizotinib inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC 50 s of 24 and 11 nM in cell-based assays, respectively. Crizotinib is also a ROS1 inhibitor. Crizotinib has effective tumor growth inhibition [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-02341066. CAS No. 877399-52-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-50878. | |
| Crizotinib hydrochloride | Crizotinib hydrochloride (PF-02341066 hydrochloride) is an orally bioavailable, selective, and ATP-competitive dual ALK and c-Met inhibitor with IC 50 s of 20 and 8 nM, respectively. Crizotinib hydrochloride (PF-02341066 hydrochloride) inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC 50 s of 24 and 11 nM in cell-based assays, respectively. It is also a ROS proto-oncogene 1 (ROS1) inhibitor. Crizotinib hydrochloride (PF-02341066 hydrochloride) has effective tumor growth inhibition [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-02341066 hydrochloride. CAS No. 1415560-69-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-50878A. | |
| Crizotinib hydrochloride | Crizotinib is inhibitor of the c-Met kinase and the NPM-ALK. Crizotinib inhibited cell proliferation in ALK-positive ALCL cells (IC50s=30 nM). Crizotinib is useful in treatment of anaplastic large-cell lymphoma. Synonyms: PF-02341066 hydrochloride; PF 02341066 hydrochloride; PF02341066 hydrochloride. Grades: >98%. CAS No. 1415560-69-8. Molecular formula: C21H23Cl3FN5O. Mole weight: 486.8. | |
| Decanoic acid | Decanoic acid is a key component of the medium-chain triglyceride (MCT) found in coconut oil. Decanoic acid is a brain-penetrant and non-competitive inhibitor of AMPA receptor showing antiseizure activity in rats. Decanoic acid reduces tyrosinase activity and inhibits melanosome maturation. Decanoic acid suppresses the phosphorylation of c-Met and induced apoptosis in hepatocellular carcinoma (HCC) cells by inhibiting the expression of various oncogenic proteins, which is promising for research in the field of mTORC1 signaling, HCC and epilepsy [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 334-48-5. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-W015309. | |
| (-)-D-Noviose | (-)-D-Noviose, a carbohydrate derivative, possesses promising therapeutic implications in the management of metabolic ailments and microbial infections. It has been established that (-)-D-Noviose manifests inhibitory tendencies towards bacterial enzymes implicated in peptidoglycan biogenesis, vital for bacterial cell wall maintenance. Furthermore, researchers have explored the applicability of (-)-D-Noviose as a putative glycosylation inhibitor in recombinant protein production, opening new avenues for biopharmaceutical research. Synonyms: 6-Deoxy-5-C-methyl-4-O-methyl-D-lyxo-hexose. CAS No. 206185-18-4. Molecular formula: C8H16O5. Mole weight: 192.21. | |
| Dovitinib Dilactic Acid | Dovitinib is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGF-1R and HER2 in cell-free assays. Synonyms: Dovitinib Dilactic acid; TKI258 Dilactic acid; CHIR-258; CHIR 258; CHIR258; TKI258; TKI 258; TKI-258. Grades: >98%. CAS No. 852433-84-2. Molecular formula: C27H33FN6O7. Mole weight: 572.59. | |
| EGFR-IN-8 | EGFR-IN-8 is a dual EGFR and c-Met inhibitor, compound 48. EGFR-IN-8 can be a promising candidate for further development to target EGFR TKI-resistant NSCLC [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2407957-87-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126320. | |
| Ficlatuzumab | Ficlatuzumab is a monoclonal antibody (McAb) targeting human hepatocyte growth factor ( HGF ). Ficlatuzumab blocks the activation of the HGF/c-Met signaling pathway, and inhibits c-Met receptor-mediated cancer cell proliferation, migration, and invasion [1]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 1174900-84-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99196. | |
| Fidaxomicin | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopychiral moleculesenzyme activators, inhibitors & substrates. Alternative Names: Lipiarmycin, (3E,5E,8S,9E,11S,12R,13E,15E,18S)-3-[[[6-Deoxy-4-O-(3,5-dichloro-2-ethyl-4,6-dihydroxybenzoyl)-2-O-methyl-?-D-mannopyranosyl]oxy]methyl]-12-[[6-deoxy-5-C-methyl-4-O-(2-methyl-1-oxopropyl)-?-D-lyxo-hexopyranosyl]oxy]-11-ethyl-8-hydroxy-18-[(1R)-1-hydroxyethyl]-9,13,15-trimethyloxacyclooctadeca-3,5,9,13,15-pentaen-2-one, Dificid, Fidaxomicin, PAR 101, Dificlir, OPT 80,Oxacyclooctadeca-3,5,9,13,15-pentaen-2-one, 3-[[[6-deoxy-4-O-(3,5-dichloro-2-ethyl-4,6-dihydroxybenzoyl)-2-O-methyl-?-D-mannopyranosyl]oxy]methyl]-12-[[6-deoxy-5-C-methyl-4-O-(2-methyl-1-oxopropyl)-?-D-lyxo-hexopyranosyl]oxy]-11-ethyl-8-hydroxy-18-[(1R)-1-hydroxyethyl]-9,13,15-trimethyl-, (3E,5E,8S,9E,11S,12R,13E,15E,18S)-, Clostomicin B1, R-Tiacumicin B, PAR 01, Lipiarmicin, Tiacumicin B, Lipiarmycin A 3, Fidaxomycin. | |
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