Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
| Product | Description | |
|---|---|---|
| cAMP-dependent protein kinase | cAMP is required to activate this enzyme. The inactive holoenzyme of cAMP-dependent protein kinase is a tetramer composed of two regulatory (R) and two catalytic (C) subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP molecules and two free monomeric catalytic subunits [i.e. R2C2 + 4 cAMP = R2(cAMP)4 + 2 C]. Group: Enzymes. Synonyms: PKA; PKA C; protein kinase A; STK22. Enzyme Commission Number: EC 2.7.11.11. CAS No. 142008-29-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3130; cAMP-dependent protein kinase; EC 2.7.11.11; 142008-29-5; PKA; PKA C; protein kinase A; STK22. Cat No: EXWM-3130. |  |
| cAMP-dependent Protein Kinase catalytic subunit from Murine, Recombinant | The catalytic subunit of cAMP-dependent Protein Kinase (PKA) is a serine/threonine protein kinase, which combines, in the absence of cAMP, with the regulatory subunit to form the inactive PKA holoenzyme. Since this is the free catalytic subunit alone, no cAMP is required for activation. Group: Enzymes. Synonyms: Protein Kinase A catalytic subunit; Protein kinase A; PKA; PKAC; cAMP-dependent protein kinase catalytic subunit; PRKAC. Enzyme Commission Number: EC 2.7.11.11. Mole weight: 38 kDa. Storage: Store at -20° C. Form: 50 mM NaCl, 20 mM Tris-HCl (pH 7.5 at 25°C), 1 mM Na2 EDTA, 2 mM DTT and 50% glycerol. Source: E. coli. Species: Murine. Protein Kinase A catalytic subunit; Protein kinase A; PKA; PKAC; cAMP-dependent protein kinase catalytic subunit; PRKAC. Cat No: NATE-1888. | |
| 4-Bromoisoquinoline | Shows selective inhibition of cAMP-dependent protein kinase. Group: Biochemicals. Alternative Names: 4-Isoquinolinyl Bromide; NSC 56333. Grades: Highly Purified. CAS No. 1532-97-4. Pack Sizes: 1g. US Biological Life Sciences. |  Worldwide |
| 6-Bn-cAMP | 6-Bn-cAMP is a selective stimulator of cAMP-dependent protein kinase which does not activate Epac. Compared to cAMP, it has superior stability against PDE, esterases, amidases and higher membrane permeability. Grades: ≥ 98% by HPLC. CAS No. 32115-08-5. Molecular formula: C17H17N5O6P · Na. Mole weight: 441.3. |  |
| 6-Bnz-cAMP | 6-Bnz-cAMP is a selective activator of cAMP-dependent protein kinase that can be used as an Epac-negative control. Compared to cAMP, it has a superior stability against PDE. Synonyms: N6- Benzoyladenosine- 3', 5'- cyclic monophosphate, sodium salt. Grades: ≥ 98% by HPLC. CAS No. 30275-80-0. Molecular formula: C17H15N5O7P · Na. Mole weight: 455.3. | |
| 8-[(6-Amino)hexyl]-amino-cAMP | 8-[(6-Amino)hexyl]-amino-cAMP, a cyclic adenosine monophosphate analog, has been found to activate protein kinase A in various studies investigating cAMP-dependent signaling and ion channel regulation. It is also being researched as a possible therapeutic approach for diseases related to ion channel dysfunction, including cystic fibrosis. This compound holds potential for advancing our understanding and treatment of these conditions. Synonyms: 8-[(6-Amino)hexyl]-amino-adenosine-3',5'-cyclic monophosphate, Sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C16H26N7O6P (free acid). Mole weight: 443.39 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-cAMP - ATTO-565 | 8-[(6-Amino)hexyl]-amino-cAMP - ATTO-565 is the fluorescent marvel revolutionizing signal transduction study in real time. This product is an invaluable academic tool, extensively utilized for research on cAMP-dependent protein kinases and their consequentiality in diseases such as cancer and diabetes. The highlight of this product is its unique fluorescent properties that empower it to detect protein interactions and signal pathways incredibly effectively. Synonyms: 8-[(6-Amino)hexyl]-amino-adenosine-3',5'-cyclic monophosphate, labeled with ATTO 565, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C47H54N9O10P (free acid). Mole weight: 935.97 (free acid). | |
| 8-[(6-Amino)hexyl]-amino-cAMP - DY-776 | DY-776 (8-[(6-Amino)hexyl]-amino-cAMP) is a biochemical with enormous potential in the realm of disease research. Specifically, it is an agent of great interest for probing cAMP-dependent signaling pathway pharmacodynamics and underlying complexities in a plethora of diseases including cancer, neurological disorders, and metabolic disorders. Further, it exhibits strong affinity for protein kinase A (PKA), making it an ideal tool for exploring the complex yet dynamic world of PKA-mediated signaling events. Synonyms: 8-[(6-Amino)hexyl]-amino-adenosine-3',5'-cyclic monophosphate, labeled with DY 776, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C60H72N9O14PS2 (free acid). Mole weight: 1238.37 (free acid). | |
| 8-ABA-cAMP | 8-ABA-cAMP is a selective cAMP analogue oreferring site B of R I of cAMP-dependent protein kinase. It is used as a ligand in affinity chromatography and can be modified with fluorophores or other markers. Synonyms: 8- (4- Aminobutyl)aminoadenosine- 3', 5'- cyclic monophosphate. Grades: ≥ 98% by HPLC. CAS No. 82927-68-2. Molecular formula: C14H22N7O6P. Mole weight: 415.4. | |
| 8-AHA-cAMP | 8-AHA-cAMP is a selective cAMP analogue preferring site B of R I of cAMP-dependent protein kinase. It can be active to site A of R I and site B of R II combining with 8-PIP-cAMP. Synonyms: 8- (6- Aminohexylamino)adenosine- 3', 5'- cyclic monophosphate. Grades: ≥ 98% by HPLC. CAS No. 39824-30-1. Molecular formula: C16H26N7O6P. Mole weight: 443.4. | |
| 8-BT-cAMP | 8-BT-cAMP is a selective activator of cAMP-dependent protein kinase. Compared to cAMP, it has superior stability and membrane permeability. Synonyms: 8- Benzylthioadenosine- 3', 5'- cyclic monophosphate, sodium salt. Grades: ≥ 98% by HPLC. CAS No. 50655-17-9. Molecular formula: C17H17N5O6PS · Na. Mole weight: 473.4. | |
| 8-NBD-cAMP | 8-NBD-cAMP is a fluorescent activator (λexc471 nm, λem536 nm) of cAMP-dependent protein kinase. 8-NBD-cAMP fluoresces strongly in hydrophobic environments. Synonyms: 8- (2-[7-Nitro-4-benzofurazanyl]aminoethylthio) adenosine-3', 5'-cyclic monophosphate, sodium salt. Grades: ≥ 95% by HPLC. CAS No. 221905-51-7. Molecular formula: C18H17N9NaO9PS. Mole weight: 589.41. | |
| Adenosine 3,5-cyclic Monophosphate, N6-Benzoyl-, Sodium Salt (6-Bnz-cAMP, Na) | A potent cell-permeable activator of cAMP-dependent protein kinase (PKA). Activates both type 1 and type 2 PKA and binds to the cAMP binding site 2 on the regulatory subunit of PKA. It is only slowly metabolized by cyclic nucleotide-dependent phosphodiesterases. Due to its considerably increased lipophilicity, it has sufficient membrane permeability for many biological systems. Group: Biochemicals. Grades: Highly Purified. CAS No. 30275-80-0. Pack Sizes: 10umol. US Biological Life Sciences. | Worldwide |
| Adenosine 3?,5?-cyclic Monophosphorothioate, 8-Bromo-, Rp-Isomer, Sodium Salt | A potent, cell-permeable, and reversible metabolically-stable cAMP antagonist that inhibits cAMP-dependent protein kinase and shows preference for PKA type I. Group: Fluorescence/luminescence spectroscopy. |  |
| Adenosine 3?,5?-cyclic Monophosphorothioate, 8-Bromo-, Sp-Isomer, Sodium Salt | A potent cell-permeable, metabolically-stable activator of cAMP-dependent protein kinase (PKA). Group: Fluorescence/luminescence spectroscopy. | |
| Adenosine 3,5-cyclic Monophosphorothioate, 8-Bromo-, Sp-Isomer, Sodium Salt (Sp-8-Br-cAMPS, Na) | A potent cell-permeable, metabolically-stable activator of cAMP-dependent protein kinase (PKA). Induces guanine nucleotide exchange factor activity of GEFI (also known as Epac) and GEFII towards Rap1 both in vivo and in vitro. Significantly more lipophilic and cell-permeable than Sp-cAMPS. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5umol. US Biological Life Sciences. | Worldwide |
| Antibiotic K252A (Antibiotic SF 2370) | Antibiotic K252A is a staurosporine analogue isolated from a Nocardiopsis strain as a potent inhibitor of protein kinase C. Antibiotic K252A exhibits potent antitumor activity but shows no antimicrobial activity in vitro, or in vivo toxicity in rodents. More extensive investigation has demonstrated that while antibiotic K252A is a potent inhibitor of Ca2+/calmodulin kinase II, it is also active against other kinases, notably myosin light chain kinase, cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and cGMP-dependent protein kinase (PKG). Group: Biochemicals. Grades: Highly Purified. CAS No. 99570-78-2. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| Bucladesine Sodium Salt | Dibutyryl-cAMP is an analog of cyclic AMP that stimulates cAMP-dependent protein kinase. Group: Biochemicals. Alternative Names: 4H-Furo[3,2-d]-1,3,2-dioxaphosphorin, Adenosine deriv.; Bucladesine Sodium; Bucladesine Sodium Salt; DC 2797; Dibutyryl 3',5'-Cyclic AMP Sodium Salt; Dibutyryl Cyclic AMP Monosodium Salt; Dibutyryl Cyclic AMP Sodium; Dibutyryl Cyclic AMP Sodium Salt; Dibutyryl-cAMP Sodium Salt; Monosodium Dibutyryl Cyclic AMP; N-6,O-2'-Dibutyryladenosine Cyclic 3',5'-Monophosphate Sodium Salt; N6,2'-O-Dibutyryl-3',5'-cyclic AMP Sodium Salt; N6,2'-O-Dibutyryladenosine-3',5'-monophosphate Monosodium Salt; N6,O2'-Dibutyryl-3',5'-cyclic AMP Sodium Salt; Sodium N6,2'-O-dibutyryladenosine 3',5'-Cyclic Phosphate; Sodium Dibutyryl 3',5'-Cyclic AMP; Sodium Dibutyryl cAMP; N-(9- β-D-Ribofuranosyl-9H-purin-6-yl)-butyramide Cyclic Hydrogen Phosphate Butyrate (ester), Monosodium Salt. Grades: Highly Purified. CAS No. 16980-89-5. Pack Sizes: 10mg, 50mg, 100mg, 250mg. Molecular Formula: C??H??N?NaO?P Na, Molecular Weight: 491.37. US Biological Life Sciences. | Worldwide |
| Calcineurin substrate | Calcineurin substrate is a peptide from the regulatory RII subunit of cAMP-dependent protein kinase. Synonyms: H-Asp-Leu-Asp-Val-Pro-Ile-Pro-Gly-Arg-Phe-Asp-Arg-Arg-Val-Ser-Val-Ala-Ala-Glu-OH; L-alpha-aspartyl-L-leucyl-L-alpha-aspartyl-L-valyl-L-prolyl-L-isoleucyl-L-prolyl-glycyl-L-arginyl-L-phenylalanyl-L-alpha-aspartyl-L-arginyl-L-arginyl-L-valyl-L-seryl-L-valyl-L-alanyl-L-alanyl-L-glutamic acid. Grades: 98%. CAS No. 113873-67-9. Molecular formula: C92H150N28O29. Mole weight: 2112.35. | |
| Calcineurin substrate acetate | Calcineurin substrate acetate is a peptide from the regulatory RII subunit of cAMP-dependent protein kinase. Synonyms: H-Asp-Leu-Asp-Val-Pro-Ile-Pro-Gly-Arg-Phe-Asp-Arg-Arg-Val-Ser-Val-Ala-Ala-Glu-OH.CH3CO2H; L-α-Aspartyl-L-leucyl-L-α-aspartyl-L-valyl-L-prolyl-L-isoleucyl-L-prolylglycyl-L-arginyl-L-phenylalanyl-L-α-aspartyl-L-arginyl-L-arginyl-L-valyl-L-seryl-L-valyl-L-alanyl-L-alanyl-L-glutamic acid acetate. Grades: ≥95%. Molecular formula: C94H154N28O31. Mole weight: 2172.40. | |
| Chelerythrine chloride | Cell permeable potent inhibitor of protein kinase C. Does not inhibit tyrosine protein kinases, cAMP-dependent protein kinase or calcium/calmodulin-dependent protein kinase. Antiplatelet, anti-inflammatory, antibacterial and antitumor compound. Apoptosis inducer in cancer cells in vitro and in vivo. Activates MAPK and JUNK signaling pathways. Affects translocation of PKC from cytosol to plasma membrane. Neurite outgrowth stimulator. Inhibits binding of BclXL to Bak (IC50 =1.5uM) or Bad proteins and stimulates apoptosis in several cancer cell lines. Blocks human P2X7 receptor. Induces cell cycle arrest in G1 phase. Specific cyclooxygenase-2 inhibitor. Group: Biochemicals. Alternative Names: NSC 36405, 1,2-Dimethoxy-N-methyl-[1,3]benzodioxolo[5,6-c]phenanthridinium chloride. Grades: Highly Purified. CAS No. 3895-92-9. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C21H18ClNO4. US Biological Life Sciences. | Worldwide |
| elongation factor 2 kinase | Requires Ca2+ and calmodulin for activity. The enzyme can also be phosphorylated by the catalytic subunit of EC 2.7.11.11, cAMP-dependent protein kinase. Elongation factor 2 is phosphorylated in several cell types in response to various growth factors, hormones and other stimuli that raise intracellular Ca2+. Group: Enzymes. Synonyms: Ca/CaM-kinase III; calmodulin-dependent protein kinase III; CaM kinase III; eEF2 kinase; eEF2K; EF2K; STK19. Enzyme Commission Number: EC 2.7.11.20. CAS No. 116283-83-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3140; elongation factor 2 kinase; EC 2.7.11.20; 116283-83-1; Ca/CaM-kinase III; calmodulin-dependent protein kinase III; CaM kinase III; eEF2 kinase; eEF2K; EF2K; STK19. Cat No: EXWM-3140. | |
| Forskolin Hemisuccinate | Forskolin Hemisuccinate is a derivative fo Forskolin (F701800), a diterpene isolated from Coleus forskohlii, possessing vasodilating and cardiostimulatory properties. Forskolin Hemisuccinate was found to inhibit E-selectin gene transcription through a cAMP-dependent protein kinase pathway. Group: Biochemicals. Alternative Names: 1-[(3R, 4aR, 5S, 6S, 6aS, 10S, 10aR, 10bS)-3-Ethenyldodecahydro-6, 10, 10b-trihydroxy-3, 4a, 7, 7, 10a-pentamethyl-1-oxo-1H-naphtho[2, 1-b]pyran-5-yl] Ester Butanedioic Acid; 1H-Naphtho[2,1-b]pyran, Butanedioic Acid Deriv. Grades: Highly Purified. CAS No. 83797-56-2. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| HA-100 | HA-100 is a potent protein kinase inhibitor, with IC 50 s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG) , cAMP-dependent protein kinase (PKA) , protein kinase C (PKC) and MLC-kinase , respectively. HA-100 also used as a ROCK inhibitor [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 84468-24-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100984. |  |
| K-252b | A staurosporine analogue isolated from a nocardiopsis strain; a potent inhibitor of protein kinase C. K-252b exhibits potent antitumour activity but shows no antimicrobial activity in vitro, or in vivo toxicity in rodents; also active against other kinases, notably myosin light chain kinase, camp-dependent protein kinase (PKA), protein kinase C (PKC) and cgmp-dependent protein kinase (PKG). Synonyms: (9r,10s,12s)-2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1h-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid. Grades: >98% by HPLC. CAS No. 99570-78-2. Molecular formula: C26H19N3O5. Mole weight: 453.45. | |
| Kemptide | Kemptide, a synthetic heptapeptide, acts as a specific substrate for cAMP-dependent protein kinase (PKA) and is shown to be a basic serine-containing heptapeptide corresponding to a sequence from pig liver pyruvate kinase. Synonyms: H-Leu-Arg-Arg-Ala-Ser-Leu-Gly-OH; L-leucyl-L-arginyl-L-arginyl-L-alanyl-L-seryl-L-leucyl-glycine; (5S,8S,11S,14S,17S,20S)-20-amino-14,17-bis(3-guanidinopropyl)-8-(hydroxymethyl)-5-isobutyl-11,22-dimethyl-4,7,10,13,16,19-hexaoxo-3,6,9,12,15,18-hexaazatricosan-1-oic acid. Grades: ≥97% by HPLC. CAS No. 65189-71-1. Molecular formula: C32H61N13O9. Mole weight: 771.91. | |
| Kemptide | Kemptide is a synthetic heptapeptide that acts as a specific substrate for cAMP-dependent protein kinase ( PKA ). Uses: Scientific research. Group: Peptides. CAS No. 65189-71-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P0248. | |
| Kemptide Phospho-Ser5 | Kemptide (Phospho-Ser5), a phosphate acceptor peptide, serves as a specific substrate for cAMP-dependent protein kinase (PKA). Synonyms: Leu-Arg-Arg-Ala-pSer-Leu-Gly; H-Leu-Arg-Arg-Ala-Ser(PO3H2)-Leu-Gly-OH; L-leucyl-L-arginyl-L-arginyl-L-alanyl-O-phosphono-L-seryl-L-leucyl-glycine; phosphokemptide; Kinase Domain of Pyruvate Kinase porcine. Grades: ≥95%. Molecular formula: C32H62N13O12P. Mole weight: 851.89. | |
| Malantide | Malantide, a highly specific substrate for PKA, is a synthetic dodecapeptide derived from the site phosphorylated by cAMP-dependent protein kinase (PKA) on the β-subunit of phosphorylase kinase. Synonyms: H-Arg-Thr-Lys-Arg-Ser-Gly-Ser-Val-Tyr-Glu-Pro-Leu-Lys-Ile-OH; L-arginyl-L-threonyl-L-lysyl-L-arginyl-L-seryl-glycyl-L-seryl-L-valyl-L-tyrosyl-L-alpha-glutamyl-L-prolyl-L-leucyl-L-lysyl-L-isoleucine. Grades: ≥95%. CAS No. 86555-35-3. Molecular formula: C72H124N22O21. Mole weight: 1633.89. | |
| Malantide acetate | Malantide acetate, a highly specific substrate for PKA, is a synthetic dodecapeptide derived from the site phosphorylated by cAMP-dependent protein kinase (PKA) on the β-subunit of phosphorylase kinase. Synonyms: H-Arg-Thr-Lys-Arg-Ser-Gly-Ser-Val-Tyr-Glu-Pro-Leu-Lys-Ile-OH.CH3CO2H; L-arginyl-L-threonyl-L-lysyl-L-arginyl-L-seryl-glycyl-L-seryl-L-valyl-L-tyrosyl-L-alpha-glutamyl-L-prolyl-L-leucyl-L-lysyl-L-isoleucine acetic acid. Grades: ≥95%. Molecular formula: C74H128N22O23. Mole weight: 1693.97. | |
| ML-7 | ML-7 is a potent and selective inhibitor of myosin light chain(MLC) kinase with Ki value of 0.3 μM. It has been shown to protect cardiac function from ischemia/reperfusion (I/R) injury. It inhibts smooth-muscle myosin light chain kinase, protein kinase C (PKC) and cAMP-dependent protein kinase (PKA). Uses: Ml-7 hydrochloride has been shown to protect cardiac function from ischemia/reperfusion (i/r) injury. Synonyms: ML7; ML 7; 1-[(5-iodo-1-naphthyl)sulfonyl]-1,4-diazepane. Grades: >98%. CAS No. 109376-83-2. Molecular formula: C15H17IN2O2S. Mole weight: 416.28. | |
| ML-7 hydrochloride | ML-7 Hcl is a cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of myosin light chain kinase (Ki = 300 nM). It also inhibt smooth-muscle myosin light chain kinase, protein kinase C (PKC) and cAMP-dependent protein kinase (PKA). Synonyms: ML-7 HCl; ML-7 hydrochloride; ML-7; ML 7; ML7. Grades: >98%. CAS No. 110448-33-4. Molecular formula: C15H18ClIN2O2S. Mole weight: 452.74. | |
| N- (2-Aminoethyl ) -5-isoquinolinesulfonamid e Hydrochloride. | A potent competitive inhibitor of protein kinase C, cGMP-, and cAMP-dependent protein kinase with respect to ATP. Group: Biochemicals. Grades: Highly Purified. CAS No. 116970-50-4. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| non-specific serine/threonine protein kinase | This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analysed to date. Group: Enzymes. Synonyms: A-kinase; AP50 kinase; ATP-protein transphosphorylase; calcium-dependent protein kinase C; calcium/phospholipid-dependent protein kinase; cAMP-dependent protein kinase; cAMP-dependent protein kinase A; casein kinase; casein kinase (phosphorylating); casein kinase 2; casein kinase I; casein kinase II; cGMP-dependent protein kinase; CK-2; CKI; CKII; cyclic AMP-dependent protein kinase; cyclic AMP-dependent protein kinase A; cyclic monophosphate-dependent protein kinase; cyclic nucleotide-dependent protein kinase; cyclin-dependent kinase; cytidine 3',5'-cyclic monophosphate-responsive protein kinase; dsk1; glycogen synthase a kinase; glycogen synthase kinase; HIPK2; Hpr kinase; hydroxyalkyl-protein kinase; hydroxyalkyl-protein kinase; M phase-specific cdc2 kinase; mitogen-activated S6 kinase; p82 kinase; phosphorylase b kinase kinase; PKA; protein glutamyl kinase; pr. Enzyme Commission Number: EC 2.7.11.1. STK. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3128; non-specific serine/threonine protein kinase; EC 2.7.11.1; A-kinase; AP50 kinase; | |
| PKA Inhibitor 14-22 Amide, Cell-Permeable, Myristoylated | Heat-stable protein kinase inhibitor (PKI) peptide sequence (14-22) that has been myristoylated at the N-terminus, enhancing its cell-permeability. The non-myristoylated version of this peptide is a highly specific inhibitor (Ki=6nM) of cAMP-dependent protein kinase. Group: Biochemicals. Alternative Names: Myr-N-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH?. Grades: Highly Purified. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| PKA inhibitor fragment (6-22) amide | PKA inhibitor fragment (6-22) amide is a synthetic peptide inhibitor of cAMP-dependent protein kinase (PKA) (Ki = 2.5 nM) derived from the heat-stable PKA inhibitor protein PKI. It is the shortest synthetic PKI peptide that retains high potency for PKA inhibition. Synonyms: PKI (6-22) amide; H-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2; L-threonyl-L-tyrosyl-L-alanyl-L-alpha-aspartyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-seryl-glycyl-L-arginyl-L-threonyl-glycyl-L-arginyl-L-arginyl-L-asparagyl-L-alanyl-L-isoleucinamide; Tyadfiasgrtgrrnai-nh2; Protein Kinase A Inhibitor Fragment 6-22 amide. Grades: ≥95%. CAS No. 121932-06-7. Molecular formula: C80H130N28O24. Mole weight: 1868.08. | |
| PKA inhibitor fragment (6-22) amide acetate | PKA Inhibitor Fragment (6-22) amide acetate is a synthetic peptide inhibitor of cAMP-dependent protein kinase (PKA) (Ki = 2.5 nM), derived from the heat-stable PKA inhibitor protein PKI. It is the shortest synthetic PKI peptide that retains high potency for PKA inhibition. Synonyms: H-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2.CH3CO2H; L-threonyl-L-tyrosyl-L-alanyl-L-alpha-aspartyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-seryl-glycyl-L-arginyl-L-threonyl-glycyl-L-arginyl-L-arginyl-L-asparagyl-L-alanyl-L-isoleucinamide acetic acid. Grades: ≥95%. Molecular formula: C82H134N28O26. Mole weight: 1928.11. | |
| PKI 14-22 amide, myristoylated | PKI 14-22 amide, myristoylated is a cell-permeable version of protein kinase inhibitor PKI (14-22) amide. N-terminus is myristoylated to increase cell membrane permeability. The non-myristoylated version of this peptide is a highly specific inhibitor of cAMP-dependent protein kinase (PKA) with Ki=36 nM. This product is a useful tool for studying PKA in cellular systems. Synonyms: Protein kinase inhibitor-(14-22)-amide, myristoylated. Grades: >98%. CAS No. 201422-03-9. Molecular formula: C53H100N20O12. Mole weight: 1209.5. | |
| PKI (5-24) | PKI (5-24) is a competitive, non-reversible peptide inhibitor of PKA (cAMP-dependent protein kinase) (Ki = 2.3 nM). Its sequence is derived from the heat-stable skeletal muscle inhibitor protein of PKA. The PKA Inhibitor peptide binds to the catalytic subunit of PKA and displaces the regulatory subunit, and mimics protein substrate by binding to the catalytic site via the Arg-cluster basic residues. Synonyms: L-threonyl-L-threonyl-L-tyrosyl-L-alanyl-L-a-aspartyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-serylglycyl-L-arginyl-L-threonylglycyl-larginyl-L-aspartic acid; PKI (5-24); Protein Kinase A Inhibitor (5-24). CAS No. 99534-03-9. Molecular formula: C94H148N32O31. Mole weight: 2222.4. | |
| PKI (5-24) acetate | PKI (5-24) acetate is a competitive, non-reversible peptide inhibitor of PKA (cAMP-dependent protein kinase) (Ki = 2.3 nM). Synonyms: H-Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-His-Asp-OH.CH3CO2H; L-Threonyl-L-threonyl-L-tyrosyl-L-alanyl-L-α-aspartyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-serylglycyl-L-arginyl-L-threonylglycyl-L-arginyl-L-arginyl-L-asparaginyl-L-alanyl-L-isoleucyl-L-histidyl-L-aspartic acid acetate salt; PKI(5-24) acetate salt. Grades: ≥95%. Molecular formula: C96H152N32O33. Mole weight: 2282.43. | |
| Protein Kinase A Catalytic Subunit β, Active human, Recombinant | cAMP-dependent protein kinase catalytic subunit beta is an enzyme that in humans is encoded by the PRKACB gene. cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the protein kinase A (PKA), which transduces the signal through phosphorylation of different target proteins. The inactive holoenzyme of PKA is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of PKA have ...e crebtide substrate peptide per minute per mg protein at 30°c using a final concentration of 50 μm [32p] atp. Group: Enzymes. Synonyms: PKA Catalytic Subunit β, Active human; PKA-Cβ; cAMP-dependent protein kinase; PKACB; PRKACB; PKA C-beta; Protein Kinase A Catalytic Subunit &beta. Purity: > 85% (SDS-PAGE). PKAC. Mole weight: protein apparent mol wt ~65 kDa. Stability: -70°C. Form: buffered aqueous glycerol solution. Source: baculovirus infected Sf9 cells. Species: Human. PKA Catalytic Subunit β, Active human; PKA-Cβ; cAMP-dependent protein kinase; PKACB; PRKACB; PKA C-beta; Protein Kinase A Catalytic Subunit &beta. Cat No: NATE-0572. | |
| Protein Kinase A Catalytic Subunit from Bovine, Recombinant | Protein Kinase A (PKA) catalyzes the transfer of the terminal phosphate of ATP to threonine or serine residues in a variety of protein substrates. The enzyme is composed of two subunit types: a catalytic subunit and a regulatory subunit. In the absence of cAMP, the two subunits are bound to each other and no catalysis can take place. In the presence of cAMP, the regulatory subunit binds cAMP, thus releasing the catalytic subunit. In the presence of cAMP, the catalytic subunit exists as a monomer of 40,862 Da (amino acid sequence), but on SDS-PAGE the apparent molecular mass is 43,000 Da. Group: Enzymes. Synonyms: PKA; cAMP-dependent protein kinase; ATP:protein phosphotransferase (cAMP-dependent); Protein K. Enzyme Commission Number: EC 2.7.11.11. Activity: >9 units/μg protein. Storage: Store at -20°C. Form: Lyophilized from a solution containing approximately: 80% sucrose, 19% potassium phosphate buffer, pH 6.7, 0.0625% 2-mercaptoethanol(2-ME), 0.002% EDTA, 0.016% dithiothreitol (DTT), and ≤1% protein. The lyophilized product may contain traces of DTT or 2-ME. Source: Bovine Heart. Species: Bovine. PKA; cAMP-dependent protein kinase; ATP:protein phosphotransferase (cAMP-dependent); Protein Kinase A catalytic subunit; Protein kinase A; PKAC; cAMP-dependent protein kinase catalytic subunit; PRKAC. Cat No: NATE-1889. | |
| Protein Kinase A catalytic subunit human, Recombinant | Ubiquitous serine-threonine kinase that phosphorylates a broad spectrum of substrates, and regulates many cellular processes. The catalytic subunit is released following binding of cyclic AMP to the regulatory subunits of the PKA holoenzyme. The free catalytic subunit has intrinsic activity and does not require added cyclic AMP. >90% (sds-page), recombinant, expressed in e. coli, buffered aqueous glycerol solution. Group: Enzymes. Synonyms: Protein Kinase A catalytic subunit; Protein kinase A; PKA; PKAC; cAMP-dependent protein kinase catalytic subunit; PRKAC. Purity: >90% (SDS-PAGE). PKAC. Mole weight: mol wt 43.5 kDa. Activity: >1000 units/mg protein. Stability: -70°C. Form: buffered aqueous glycerol solution. Source: E. coli. Species: Human. Protein Kinase A catalytic subunit; Protein kinase A; PKA; PKAC; cAMP-dependent protein kinase catalytic subunit; PRKAC. Cat No: NATE-0571. | |
| Protein Kinase Inhibitor H-9 (PKI) (N- (2-aminoethyl ) -5-isoquinolinesulfonamid e dihydrochloride) | Competitive inhibitor of protein kinase C, cGMP- and cAMP-dependent protein kinases with respect to ATP binding. Group: Biochemicals. Alternative Names: N- (2-aminoethyl ) -5-isoquinolinesulfonamid e dihydrochloride. Grades: Molecular Biology Grade. CAS No. 84468-17-7. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Rp-2',3'-cAMPS | Rp-2',3'-cAMPS, a powerful stimulant of cAMP-dependent protein kinase (PKA), finds extensive application in biochemistry and biomedical research. By emulating the impact of endogenous cAMP, it effectively triggers PKA signaling pathways. The versatility of this compound allows for its frequent utilization in investigating the involvement of PKA in cellular signaling, gene expression, and the modulation of diverse diseases and disorders. Synonyms: Adenosine- 2', 3'- cyclic monophosphorothioate, endo / Rp- isomer, sodium salt. Grades: ≥ 97% by HPLC. CAS No. 118275-99-3. Molecular formula: C10H11O5N5PS · Na. Mole weight: 367.3. | |
| Rp-5,6-DCl-cBIMPS | Rp-5,6-DCl-cBIMPS is a phosphodiesterase-resistant regulator of cAMP-dependent protein kinase. Synonyms: 5, 6- Dichlorobenzimidazole riboside- 3', 5'- cyclic monophosphorothioate, Rp- isomer, sodium salt. Grades: ≥ 99% by HPLC. CAS No. 120912-55-2. Molecular formula: C12H10Cl2N2O5PS · Na. Mole weight: 419.2. | |
| Rp-8-bromo-Cyclic AMPS sodium salt | Rp-8-bromo-Cyclic AMPS is a cell-permeable cAMP analog and an antagonist of cAMP-dependent protein kinases (PKAs). Synonyms: 8-Bromoadenosine 3',5'-cyclic monophosphorothioate, Rp-isomer; Rp-8-Br-cAMPS; Rp-8-bromo-cAMPS. Grades: ≥98%. CAS No. 925456-59-3. Molecular formula: C10H10BrN5O5PS·Na. Mole weight: 446.1. | |
| Sp-2',3'-cAMPS | Sp-2',3'-cAMPS is a crucial cyclic nucleotide analog acting as an activator of protein kinase A (PKA), enabling the study of its role in signal transduction pathways. This product is widely used in biomedical field research to investigate the modulation of PKA activity and its implications in various drug responses and diseases involving cAMP-dependent signaling pathways. Synonyms: Adenosine- 2', 3'- cyclic monophosphorothioate, exo / Sp- isomer, sodium salt. Grades: ≥ 97% by HPLC. CAS No. 118276-00-9. Molecular formula: C10H11N5O5PS · Na. Mole weight: 367.3. | |
| Sp-6-Bnz-cAMPS | Sp-6-Bnz-cAMPS is a selective and PDE-resistant stimulator of cAMP-dependent protein kinase, which can be used as an Epac-negative control. Grades: ≥ 98% by HPLC. CAS No. 152218-18-3. Molecular formula: C17H15N5O6PS · Na. Mole weight: 471.4. | |
Our database is helping our users find suppliers everyday.
