Carbamate Kinase Suppliers USA
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Product | Description | |
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CARBAMATE KINASE Quick inquiry Where to buy Suppliers range | CARBAMATE KINASE. Group: Heterocyclic Organic Compound. Grades: 96%. CAS No. 9026-69-1. | |
1,1,1-Trifluoro-methanesulfonic Acid 3-[[ (1, 1-Dimethylethoxy) carbonyl]amino]-1-cyclohexen-1-yl Ester Quick inquiry Where to buy Suppliers range | 1,1,1-Trifluoro-methanesulfonic Acid 3-[[ (1, 1-Dimethylethoxy) carbonyl]amino]-1-cyclohexen-1-yl Ester is an intermediate in synthesizing tert-Butyl (3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohex-3-en-1-yl)carbamate (T302650), which is a reactant in the preparation of furo[3,2-c]pyridine derivatives as protein kinase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 1803033-60-4. Pack Sizes: 25mg, 50mg. Molecular Formula: C12H18F3NO5S. US Biological Life Sciences. | Worldwide |
1,1,1-Trifluoro-methanesulfonic Acid 5-[[ (1, 1-Dimethylethoxy) carbonyl]amino]-1-cyclohexen-1-yl Ester Quick inquiry Where to buy Suppliers range | 1,1,1-Trifluoro-methanesulfonic Acid 5-[[ (1, 1-Dimethylethoxy) carbonyl]amino]-1-cyclohexen-1-yl Ester is an intermediate in synthesizing tert-Butyl (3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohex-3-en-1-yl)carbamate (T302650), which is a reactant in the preparation of furo[3,2-c]pyridine derivatives as protein kinase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 1803033-59-1. Pack Sizes: 25mg, 50mg. Molecular Formula: C12H18F3NO5S. US Biological Life Sciences. | Worldwide |
1-Benzyl -4-benzyl oxycarbonyl aminopiperidine Quick inquiry Where to buy Suppliers range | Intermediate used in the preparation p-38 kinase inhibitors and serotonin antagonists. Group: Biochemicals. Alternative Names: [1-(Phenylmethyl)-4-piperidinyl]carbamic Acid Phenylmethyl Ester; [1-(Benzyl)-4-piperidinyl]carbamic Acid Benzyl Ester; Benzyl (1-Benzylpiperidin-4-yl)carbamate; N-(Benzyloxycarbonyl)-1-benzylpiperidin-4-ylamine. Grades: Highly Purified. CAS No. 182223-53-6. Pack Sizes: 500mg. US Biological Life Sciences. | Worldwide |
((1R,3R)-3-Amino-cyclopentyl)-carbamic Acid tert-Butyl Ester Quick inquiry Where to buy Suppliers range | ((1R,3R)-3-Amino-cyclopentyl)-carbamic Acid tert-Butyl Ester is used in the preparation of quinoline-3-carboxoamides as H-PGDS inhibitors as well as novel triazolo-pyrrolopyridines as Janus kinase 1 inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 1009075-44-8. Pack Sizes: 5mg, 10mg. Molecular Formula: C10H20N2O2, Molecular Weight: 200.28. US Biological Life Sciences. | Worldwide |
(1R) -N-Boc-1-[4- (hydroxymethyl) cyclohexyl]ethan-1-amine Quick inquiry Where to buy Suppliers range | Intermediate in the production of Rho kinase inhibitors and neurite outgrowth promoters. Group: Biochemicals. Alternative Names: (1R) -N- (tert-Butyloxycarbonyl) -1-[4- (hydroxymethyl) cyclohexyl]ethan-1-amine; [ (1R) -1- [4- (Hydroxymethyl) cyclohexyl] ethyl] carbamic Acid 1,1-Dimethylethyl Ester. Grades: Highly Purified. CAS No. 627314-62-4. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
(1R)-trans-4-[N-Boc-1-aminoethyl]-N-4-pyridinyl-cyclohexanecarboxamide Quick inquiry Where to buy Suppliers range | Protected Y-27632, a Rho kinase inhibitor (ROCK) for the treatment of ischemia-reperfusion disorders. Group: Biochemicals. Alternative Names: [ (1R) -1- [trans-4- [ (4-Pyridinylamino) carbonyl] cyclohexyl] ethyl] carbamic Acid 1,1-Dimethylethyl Ester; N-Boc-Y-27632. Grades: Highly Purified. CAS No. 671816-04-9. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
(3- (5- (4-Acetamidophenyl sulfonamido) -6-methoxypyrazin-2-yl ) propyl ) carbamate tert-Butyl Ester Quick inquiry Where to buy Suppliers range | (3- (5- (4-Acetamidophenyl sulfonamido) -6-methoxypyrazin-2-yl ) propyl ) carbamate tert-Butyl Ester is an intermediate in the synthesis of biotin-linked derivatives of Necrosulfonamide (N388600), a compound that specifically blocks necrosis downstream of receptor-interacting serine-threonine kinase 3 (RIP3) activation. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
(3-(5-Amino-6-methoxypyrazin-2-yl)propyl)carbamate tert-Butyl Ester Quick inquiry Where to buy Suppliers range | (3-(5-Amino-6-methoxypyrazin-2-yl)propyl)carbamate tert-Butyl Ester is an intermediate in the synthesis of biotin-linked derivatives of Necrosulfonamide (N388600), a compound that specifically blocks necrosis downstream of receptor-interacting serine-threonine kinase 3 (RIP3) activation. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
(3-Aminopropyl)ethyl-carbamic Acid tert-Butyl Ester Quick inquiry Where to buy Suppliers range | (3-Aminopropyl)ethyl-carbamic Acid tert-Butyl Ester is a reactant used in the preparation of pyrimidin-2-one derivatives as CSBP/RK/p38 kinase inhibitors. Group: Biochemicals. Alternative Names: (3-Aminopropyl)ethyl-carbamic Acid 1,1-Dimethylethyl Ester; tert-Butyl N-(3-Aminopropyl)-N-(ethyl)carbamate. Grades: Highly Purified. CAS No. 273409-54-4. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
4-Benzyl oxycarbonyl aminopiperidine Hydrochloride Quick inquiry Where to buy Suppliers range | Intermediate used in the preparation of certain antibiotics, p-38 kinase inhibitors, and serotonin antagonists. Group: Biochemicals. Alternative Names: 4-Cbz-aminopiperidine Hydrochloride; 4-Piperidinyl-carbamic Acid Phenylmethyl Ester Hydrochloride; 4-Piperidinyl-carbamic Acid Benzyl Ester Hydrochloride; Benzyl Piperidin-4-ylcarbamate Hydrochloride; 4-[ (Carbobenzyloxy) amino]piperidine Hydrochloride. Grades: Highly Purified. CAS No. 207296-89-7. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
6-MBC-cAMP Quick inquiry Where to buy Suppliers range | 6-MBC-cAMP is a selective activator of protein kinase A, the cAMP agonist, which has a preference for the A site of cAK II. It can be active to type II in combination of Sp-5,6-DCl-cBIMPS. Synonyms: 6-MBC-CAMP SODIUM SALT; 84433-46-5; sodium; N-[[9-(7-hydroxy-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl)purin-6-yl]carbamoyl]-2,2-dimethylpropanamide; 6-MBC-cAMP. Grades: ≥ 98% by HPLC. CAS No. 84433-46-5. Molecular formula: C15H20N6O7P · Na. Mole weight: 450.3. | |
AC480 Quick inquiry Where to buy Suppliers range | AC480, also known as BMS-599626, is an orally bioavailable inhibitor of the HER1, HER2 and HER4 tyrosine kinases (IC50 =22, 32 and 190 nM, respectively) with potential antineoplastic activity. BMS-599626 inhibits human epidermal growth factor receptors (HER) HER1, HER2 and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors. Synonyms: BMS-599626; BMS 599626; BMS599626; AC 480; AC-480; Carbamic acid, N-[4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-, (3S)-3-morpholinylmethyl ester; (3S)-3-Morpholinylmethyl N-[4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamate; Carbamic acid, [4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-, (3S)-3-morpholinylmethyl ester; N-[4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-carbamic acid, (3S)-3-morpholinylmethyl ester. Grades: ≥95%. CAS No. 714971-09-2. Molecular formula: C27H27FN8O3. Mole weight: 530.55. | |
AP-22408 Quick inquiry Where to buy Suppliers range | AP-22408, a Src tyrosine kinase inhibitor, is an orally bioavailable phosphotyrosine mimic resulting from a structurebased design. Synonyms: [4-[(2S)-2-acetamido-3-[[(5S)-3-carbamoyl-2-(cyclohexylmethoxy)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-yl]amino]-3-oxopropyl]-2-phosphonophenyl]phosphonic acid; AP-22408; AP 22408; AP22408; UNII-3U3L5QR4KV; CC1; AC1L9I7C; 3U3L5QR4KV; SCHEMBL7245569. Grades: >98%. CAS No. 268741-43-1. Molecular formula: C30H41N3O10P2. Mole weight: 665.61. | |
AS-2444697 HCl Quick inquiry Where to buy Suppliers range | AS-2444697 is a pootent and selective interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor (IC50 = 21 nM) with 30-fold selectivity for IRAK4 over IRAK1. AS2444697 significantly reduced or showed a decreasing trend in expression and levels of these inflammatory parameters. Synonyms: N-(3-carbamoyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-2-(2-methylpyridin-4-yl)oxazole-4-carboxamide hydrochloride; AS-2444697; AS 2444697; AS2444697; AS-2444697 HCl; AS-2444697 hydrochloride. CAS No. 1287665-60-4. Molecular formula: C19H21ClN6O4. Mole weight: 432.86. | |
BMS-599626 Hydrochloride Quick inquiry Where to buy Suppliers range | BMS-599626 Hydrochloride is a selective and efficacious orally bioavailable inhibitor of the HER1, HER2 and HER4 tyrosine kinases with potential antineoplastic activity. It inhibits human epidermal growth factor receptors (HER) HER1, HER2 and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors. Synonyms: AC480 hydrochloride; AC 480 hydrochloride; AC-480 hydrochloride; BMS-599626 HCl; BMS-599626 monohydrochloride; BMS 599626 Hydrochloride; BMS599626 hydrochloride; Carbamic acid, N-[4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-, (3S)-3-morpholinylmethyl ester, hydrochloride (1:1); Carbamic acid, [4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-, (3S)-3-morpholinylmethyl ester, monohydrochloride; (S)-Morpholin-3-ylmethyl (4-((1-(3-fluorobenzyl)-1H-indazol-5-yl)imino)-5-methyl-1,4-dihydropyrrolo[2,1-f][1,2,4]triazin-6-yl)carbamate hydrochloride. Grades: >98%. CAS No. 873837-23-1. Molecular formula: C27H28ClFN8O3. Mole weight: 567.01. | |
BMS-908662 Quick inquiry Where to buy Suppliers range | BMS-908662 is a Raf kinase inhibitor with potential antineoplastic activity. It can specifically inhibit RAF kinases, located downstream from RAS in the RAS/RAF/MEK/ERK kinase signaling pathway, which may result in reduced proliferation of tumor cells. Phase I for the treatment of Colorectal cancer and Malignant melanoma was discontinued. Uses: Colorectal cancer; malignant melanoma. Synonyms: methyl (5-(2-(5-chloro-2-methylphenyl)-1-hydroxy-3-oxoisoindolin-1-yl)-1H-benzo[d]imidazol-2-yl)carbamate;BMS908662; BMS-908662; BMS 908662; XL281; XL 281; XL-281. Grades: 98%. CAS No. 870603-16-0. Molecular formula: C24H19ClN4O4. Mole weight: 462.89. | |
CCG215022 Quick inquiry Where to buy Suppliers range | CCG215022 is a G protein-coupled receptor kinases (GRKs) inhibitor (IC50s= 0.15±0.07 μM, 0.38±0.06 μM and 3.9±1 μM for GRK2, GRK5 and GRK1, respectively), with good selectivity against other closely related kinases such as GRK1 and PKA. Synonyms: 4-(4-fluoro-3-((pyridin-2-ylmethyl)carbamoyl)phenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide; CCG215022; CCG 215022; CCG-215022. CAS No. 1813527-81-9. Molecular formula: C26H22FN7O3. Mole weight: 499.5. | |
eCF506 Quick inquiry Where to buy Suppliers range | eCF506 is a potent and highl selective inhibitor towards Src tyrosine kinase with a 1000-fold selectivity over ABL. eCF506 inhibits SRC at subnanomolar concentration (IC50 < 0.5 nM). It is said that eCF506 is the first drug candidate of a second generation of Src inhibitors that will not only help to understand the complexity of some cancers but also the development of safer combination therapies. Synonyms: eCF506; eCF-506; eCF 506.; tert-butyl N-[4-[4-amino-1-[2-[4-(dimethylamino)piperidin-1-yl]ethyl]pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl]carbamate; eCF506; Derivative 11a; GTPL9186; derivative 11a [PMID: 27115835]; tert-butyl N-[4-(4-amino-1-{2-[4-(dimethylamino)piperidin-1-yl]ethyl}-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxyphenyl]carbamate. Grades: >98%. CAS No. 1914078-41-3. Molecular formula: C26H38N8O3. Mole weight: 510.643. | |
EDA-ADP - 5/6-TAMRA Quick inquiry Where to buy Suppliers range | EDA-ADP - 5/6-TAMRA, a fluorescently labeled nucleotide analogue, is a versatile tool with immense potential in the biomedicine field. Its application extends to studying protein-ligand interactions and enzyme kinetics, with a special focus on kinases and phosphatases associated with cancer and neurological disorders. The compound assists drug discovery researchers in designing and developing targeted drugs that aim to combat specific biomolecules associated with illnesses. Its significance and indispensability are undeniable in the quest towards unraveling the mysteries of various diseases. Synonyms: 2'/3'-O-(2-Aminoethyl-carbamoyl)-Adenosine-5'-diphosphate, labeled with 5/6-TAMRA, Triethylammonium salt. Grades: ≥ 95 % by HPLC. Molecular formula: C38H41N9O15P2(free acid). Mole weight: 925.74 (free acid). | |
EDA-ADP - ATTO-540Q Quick inquiry Where to buy Suppliers range | EDA-ADP - ATTO-540Q, a highly specialized fluorescent probe tailored for the purpose of detecting ADP. Generally utilized within the realm of nucleotide metabolism and in cohort with the likes of kinases and ATPases, this remarkable probe's distinct spectral features enable it to excel in fluorescent assays and microscopy, providing unparalleled sensitivity and resolution when it comes to ADP-related activities. Synonyms: 2'/3'-O-(2-Aminoethyl-carbamoyl)-Adenosine-5'-diphosphate, labeled with ATTO 540Q, Triethylammonium salt. Grades: ≥ 95 % by HPLC. Molecular formula: C13H21N7O11P2- ATTO 540Q (free acid). Mole weight: 1053.29 (free acid). | |
EDA-ATP - ATTO-MB2 Quick inquiry Where to buy Suppliers range | EDA-ATP - ATTO-MB2 is a fluorescent marker molecule used to study ATP-dependent biological processes. It exhibits strong fluorescence upon binding to ATP-consuming enzymes, such as kinases and ATPases, facilitating drug development for diseases like cancer and metabolic disorders. Synonyms: 2'/3'-O-(2-Aminoethyl-carbamoyl)-Adenosine-5'-triphosphate, labeled with ATTO-MB2, Triethylammonium salt. Grades: ≥ 95 % by HPLC. Molecular formula: C32H41N10O15P3S (free acid). Mole weight: 930.71 (free acid). | |
EDA-ATPγS - ATTO-425 Quick inquiry Where to buy Suppliers range | EDA-ATPγS - ATTO-425, an irrevocable fluorescent labeling reagent, is intensively researched in biomedical laboratories for its ability to reveal and interpret protein behavior in signal transduction pathways. With particular interest in kinase activity, this reagent plays an instrumental role in comprehending the mechanisms underlying cancer and neurological diseases. Synonyms: 2'/3'-O-(2-Aminoethyl-carbamoyl)-adenosine-5'-(γ-thio)-triphosphate, labeled with ATTO 425, Triethylammonium salt. Grades: ≥ 90 % by HPLC, contains approx. 5 % EDA-ADP-dye. Molecular formula: C35H47N8O18P3S (free acid). Mole weight: 992.78 (free acid). | |
EDA-ATPγS - ATTO-655 Quick inquiry Where to buy Suppliers range | EDA-ATPγS - ATTO-655, a potent fluorescent probe, is extensively utilized in the biomedicine arena to scrutinize ATP hydrolysis. Demonstrated to proficiently tag proteins, it is particularly optimal for examining ATP-dependent pathways in ion channels, kinases, and other ATPases. Furthermore, this valuable tool is instrumental in the study of maladies linked to ATP hydrolysis, including certain kinds of cancer and diabetes. Synonyms: 2'/3'-O-(2-Aminoethyl-carbamoyl)-adenosine-5'-(γ-thio)-triphosphate, labeled with ATTO 655, Triethylammonium salt. Grades: ≥ 90 % by HPLC, contains approx. 5 % EDA-ADP-dye. Molecular formula: C13H22N7O13P3S - ATTO 655 (free acid). Mole weight: 1118.33 (free acid). | |
EDA-ATPγS - Cy5 Quick inquiry Where to buy Suppliers range | EDA-ATPγS-Cy5 is a fluorescent kinase assay substrate used for analyzing kinase activities in vitro. It serves as a useful tool for researchers studying signaling pathways and drug discovery efforts surrounding diseases such as cancer and autoimmune disorders. Synonyms: 2'/3'-O-(2-Aminoethyl-carbamoyl)-adenosine-5'-(γ-thio)-triphosphate, labeled with Cy5, Triethylammonium salt. Grades: ≥ 90 % by HPLC, contains approx. 5 % EDA-ADP-dye. Molecular formula: C46H60N9O20P3S3(free acid). Mole weight: 1248.13 (free acid). | |
Encorafenib Quick inquiry Where to buy Suppliers range | Encorafenib, also known as LGX-818, is an orally available Raf kinase inhibitor with potential antineoplastic activity. LGX818 specifically inhibits Raf kinase, a serine/threonine enzyme in the RAF/mitogen-activated protein kinase kinase (MEK)/extracellular signal-related kinase (ERK) signaling pathway. By inhibiting the activation of the RAF/MEK/ERK signaling pathway, the administration of LGX818 may result in a decrease in proliferation of tumor cells. The Raf mutation BRAF V600E is frequently upregulated in a variety of human tumors and results in the constitutive activation of the RAF/MEK/ERK signaling pathway that regulates cellular proliferation and survival. Synonyms: LGX818; LGX-818; LGX 818; Methyl N-[(2S)-1-[[4-[3-[5-chloro-2-fluoro-3-(methanesulfonamido)phenyl]-1-propan-2-ylpyrazol-4-yl]pyrimidin-2-yl]amino]propan-2-yl]carbamate. Grades: ≥98%. CAS No. 1269440-17-6. Molecular formula: C22H27ClFN7O4S. Mole weight: 540.011. | |
Entinostat Quick inquiry Where to buy Suppliers range | Entinostat is a histone deacetylase (HDAC) inhibitor displaying antiproliferative and antineoplastic effects. Entinostat induces cyclin-dependent kinase inhibitor 1A (p21/CIP1/WAF1), which slows cell growth, differentiation, and tumor development in vivo. Entinostat is potentially used as an antitumor drug in combination with other drugs like adriamycin, PARP inhibitors and Hsp90 inhibitors. Uses: Histone deacetylase inhibitors. Synonyms: MS275; MS-275; MS 2275; SNDX275; SNDX-275; SNDX 275; Entinostat; pyridin-3-ylmethyl N-[[4-[ (2-aminophenyl) carbamoyl]phenyl]methyl]carbamate. Grades: > 98%. CAS No. 209783-80-2. Molecular formula: C21H20N4O3. Mole weight: 376.416. | |
ethyl (2-fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)carbamate Quick inquiry Where to buy Suppliers range | An impurity of Regorafenib. Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Synonyms: Regorafenib Impurity 06. CAS No. 2514957-39-0. Molecular formula: C16H16FN3O4. Mole weight: 333.31. | |
Ethyl (4-((2-(Methylcarbamoyl)pyridin-4-yl)oxy)phenyl)carbamate Quick inquiry Where to buy Suppliers range | An impurity of Sorafenib. Sorafenib is a small inhibitor of several tyrosine protein kinases, such as VEGFR, PDGFR and Raf family kinases, for the treatment of primary kidney cancer, advanced primary liver cancer and radioactive iodine resistant advanced thyroid carcinoma. Synonyms: PAPE-ethyl Carbamate; Sorafenib related compound 7. Grades: > 98%. CAS No. 2206827-12-3. Molecular formula: C16H17N3O4. Mole weight: 315.32. | |
Geldanamycin (Streptomyces hygroscopicus) 98+% Quick inquiry Where to buy Suppliers range | Geldanamycin is benzoquinone ansamycin antibiotic isolated from Streptomyces hygroscopicus. A potent antitumor 1 and potent inhibitor of p60c-crc tyrosine kinase, erb B2,2 EGF receptor tyrosine kinase and non-receptor tyrosine kinases. 3, Geldanamycin binds specifically and inhibits the chaperone protein Hsp90.2. Group: Biochemicals. Alternative Names: 9, 13-Dihydroxy-8, 14, 19-trimethoxy-4, 10, 12, 16-tetramethyl-2-azabicyclo[16. 3. 1]docosa-4, 6, 10, 18, 21-pentaene-3, 20, 22-trione 9-Carbamate; (+)-Geldanamycin; NSC 122750; NSC 212518; BRN1633093. Grades: Highly Purified. CAS No. 30562-34-6. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
Imatinib EP Impurity D Quick inquiry Where to buy Suppliers range | An impurity of Imatinib, a tyrosine kinase inhibitor used as a chemotherapy drug for the treatment of leukemia and other kinds of cancer. Synonyms: Des(methylpiperazinyl) Imatinib Dimer Piperazinium Chloride; 1-Methyl-1, 4-bis[4-[ (4-methyl-3-[[4- (pyridin-3-yl) pyrimidin-2-yl]amino]phenyl) carbamoyl]benzyl]piperazin-1-ium chloride. Grades: > 95%. CAS No. 1821122-73-9. Molecular formula: C53H51ClN12O2. Mole weight: 923.50. | |
Indole-5-carboxamide Quick inquiry Where to buy Suppliers range | SD-169 is an ATP-competitive and orally bioactive inhibitor of p38α MAP kinase (IC50 = 3.2 nM) with 38 fold selectivity over p38β MAP kinase (IC50 = 122 nM). SD-169 decreases p38 MAP kinase expression in T cells, lowers blood glucose and reduces the risk of diabetes. It has no inhibitory effect against a panel of other kinases including p38γ MAP kinase, ERK2, JNK-1 and MAPKAPK-2. Synonyms: SD-169; SD169; 5-(Aminocarbonyl)-1H-indole; 5-Carbamoylindole. Grades: 99 %. CAS No. 1670-87-7. Molecular formula: C9H8N2O. Mole weight: 160.17. | |
Mirk/Dyrk1B Inhibitor, Compound A (N- (2-Chloro-5- (3-chlorobenzylcarbamoyl) phenyl) -2-methoxy-7-oxo-7, 8-dihydropyrido[2, 3-d]pyrimidine-6-carboxamide, N- (2-Chloro-5- ( (3-chlorobenzyl) carbamoyl) phenyl) -7-hydroxy-2-methoxypyrido[2, 3-d]pyrimidine-6-carboxamide) Quick inquiry Where to buy Suppliers range | A cell-permeable di hydropyridopyrimidine-carboxamide compound that acts as a potent and reversible inhibitor of Mirk/Dyrk1B and Dyrk1A kinases (IC50 = 68 and 22nM). Exhibits very high selectivity for Mirk/Dyrk1B compared to Abl, Flt3, and MARK1 (64, 56 and 73% inhibition at 10uM, respectively) and a panel of 46 other kinases. Shown to induce activation of caspase-3 and sensitize tumor cells to the action of gemcitabine and cisplatin, possibly by de-stabilizing p27. Preferentially increases cycling in Mirk-elevated quiescent pancreatic cancer cells (SU86.86, Panc1, AsPc1, and SW620 at ~1uM). Also, shown to increase level of superoxides in quiescent pancreatic tumor cells (Panc1, SU86.86, and AsPc1) by blocking SOD2 and SOD3 activities. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
MPS1 Inhibitor, NMS-P715 ( (N- (2, 6-diethylphenyl) -1-methyl-8- ({4-[ (1-methylpiperidin-4-yl) carbamoyl]-2- (trifluoromethoxy) phenyl}amino) -4, 5-dihydro-1H-pyrazolo[4, 3-h]quinazoline-3-carboxamide) ) Quick inquiry Where to buy Suppliers range | An orally bioavailable, ATP-competitive, pyrazolo-quinazoline, MPS1 inhibitor (IC50=182nM, Ki=0.99nM) that is shown to act in a reversible and time-dependent manner. It demonstrates selectivity for MPS1 against a panel of 60 kinases, displaying activity against only three kinases, CK2, MELK, and NEK6 (<10uM), but not against other mitotic kinases including PLK1, CDK1, Aurora A, Aurora B, or the SAC kinase BUB1, in an in vitro kinase assay. It promotes massive SAC (spindle assembly checkpoint) override (EC50=65nM) in nocodazole-arrested U20S cells and elicits a reduction in the G1 and G2/M phase of the cell cycle in A2780 ovarian cancer cells, similar to RNAi-mediated MPS1 silencing. In addition, it is shown to inactivate SAC, delocalize kinetochore components, and inhibit the proliferation of select cancer cell lines (IC50 ~1uM), without marked activity among a panel of 127 normal cell lines. Also, it inhibits A2780 tumor xenograft growth in mice (90mg/kg/day, o.s., in vivo) by 53% wit Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
N-tert-Butyloxycarbonyl-D-erythro-dihydro-D-sphingosine Quick inquiry Where to buy Suppliers range | Protected D-erythro-C18-Dihydro-D-sphingosine. Biosynthetic precursor of Sphingosine. Inhibits protein kinase C. Group: Biochemicals. Alternative Names: N-[ (1S, 2R) -2-Hydroxy-1- (hydroxymethyl) heptadecyl]carbamic Acid 1,1-Dimethylethyl Ester. Grades: Highly Purified. CAS No. 140408-14-6. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
N-tert-Butyloxycarbonyl Serotonin Quick inquiry Where to buy Suppliers range | Protected Serotonin (S274980), a monoamine neurotransmitter. Used in the preparation of protein kinase inhibitors and receptor agonists. Group: Biochemicals. Alternative Names: [2-(5-Hydroxy-1H-indol-3-yl)ethyl]carbamic Acid 1,1-Dimethylethyl Ester; 3-[2-N-(tert-Butoxycarbonyl)amino]-1H-indole-5-ol. Grades: Highly Purified. CAS No. 53157-48-5. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
N-tert-Butyloxycarbonyl Y-27632-d4 (ROCK Inhibitor) Quick inquiry Where to buy Suppliers range | Protected Y-27632-d4. A labeled Rho kinase inhibitor (ROCK) for the treatment of ischemia-reperfusion disorders. Group: Biochemicals. Alternative Names: trans-4-[ (R) -1-[ (tert-Butyloxycarbonyl) amino]ethyl]-N- (4-pyridyl) cyclohexanecarboxamide-d4; [ (1R) -1- [trans-4- [ (4-Pyridinyl-d4-amino) carbonyl] cyclohexyl] ethyl] -carbamic Acid 1,1-Dimethyethyl Ester. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
Regorafenib Impurity 6 Quick inquiry Where to buy Suppliers range | An impurity of Regorafenib.Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Synonyms: Regorafenib Impurity 6; Regorafenib metabolite M6; 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)picolinic acid; ZU2HG2Y956; UNII-ZU2HG2Y956; 2-Pyridinecarboxylic acid, 4- (4- ( ( ( (4-chloro-3- (trifluoromethyl) phenyl) amino) carbonyl) amino) -3-fluorophenoxy) -; 4- (4- ( (4-Chloro-3- (trifluoromethyl) phenyl) carbamoylamino) -3-fluoro-phenoxy) pyridine-2-carboxylic acid; 4-[4-[[4-chloro-3- (trifluoromethyl) phenyl]carbamoylamino]-3-fluorophenoxy]pyridine-2-carboxylic acid; SCHEMBL4609009; 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy) picolinic acid. Grades: > 95%. CAS No. 1187945-05-6. Molecular formula: C20H12ClF4N3O4. Mole weight: 469.78. | |
(R) -N-Boc-1- [4- (tert-butyldi methyl silyloxy methyl ) cyclohexyl] ethan-1-amine Quick inquiry Where to buy Suppliers range | Intermediate in the production of Rho kinase inhibitors and neurite outgrowth promoters. Group: Biochemicals. Alternative Names: [ (1R) -1- [4- [ [ [ (1, 1-Dimethylethyl) dimethylsilyl] oxy] methyl] cyclohexyl] ethyl] carbamic Acid 1,1-Dimethylethyl Ester. Grades: Highly Purified. CAS No. 672314-58-8. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
(R)-tert-butyl 1-aminopropan-2-ylcarbamate Quick inquiry Where to buy Suppliers range | (R)-tert-butyl 1-aminopropan-2-ylcarbamate (CAS# 100927-10-4) is used as an intermediate in the preparation of potent benzothiophene inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK2). Synonyms: N-[(2R)-1-aminopropan-2-yl]carbamic acid tert-butyl ester; tert-butyl N-[(2R)-1-aminopropan-2-yl]carbamate. CAS No. 100927-10-4. Molecular formula: C8H18N2O2. Mole weight: 174.24. | |
Sorafenib Related Compound 14 Quick inquiry Where to buy Suppliers range | An impurity of Sorafenib. Sorafenib is a small inhibitor of several tyrosine protein kinases, such as VEGFR, PDGFR and Raf family kinases, for the treatment of primary kidney cancer, advanced primary liver cancer and radioactive iodine resistant advanced thyroid carcinoma. Synonyms: 4-[4-[[[[4-Chloro-3- (trifluoromethyl) phenyl]amino]carbonyl]amino]phenoxy]-2-pyridinecarboxamide; BAY 43-9007; N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[4-(2-carbamoyl-4-pyridyloxy)phenyl]urea; N-Desmethyl Sorafenib. Grades: > 95%. CAS No. 284461-74-1. Molecular formula: C20H14ClF3N4O3. Mole weight: 450.81. | |
Sorafenib related compound 2 Quick inquiry Where to buy Suppliers range | An impurity of Sorafenib. Sorafenib is a small inhibitor of several tyrosine protein kinases, such as VEGFR, PDGFR and Raf family kinases, for the treatment of primary kidney cancer, advanced primary liver cancer and radioactive iodine resistant advanced thyroid carcinoma. Synonyms: N-[4-Chloro-3-(trifluoromethyl)phenyl]carbamic Acid Ethyl Ester; [4-Chloro-3-(trifluoromethyl)phenyl]carbamic Acid Ethyl Ester; 4-Chloro-3-(trifluoromethyl)carbanilic Acid Ethyl Ester; Ethyl (4-Chloro-3-(trifluoromethyl)phenyl)carbamate. Grades: > 95%. CAS No. 18585-06-3. Molecular formula: C10H9ClF3NO2. Mole weight: 267.64. | |
SR 1664 Quick inquiry Where to buy Suppliers range | SR 1664 is a PPARγ (peroxisome proliferator-activated receptor γ ) inhibitor. SR 1664 can block PPARγ by cyclin-dependent kinase 5 with an IC50 value of 80 nM and it does not exhibit agonist activity at the PPARγ receptor. Recent research shows that SR 1664 has anti-diabetic effects in obese mice. Uses: Antidiabetic activity. Synonyms: SR1664; SR-1664; SR 1664. (S)-4'-((2,3-dimethyl-5-((1-(4-nitrophenyl)ethyl)carbamoyl)-1H-indol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid. Grades: 98%. CAS No. 1338259-05-4. Molecular formula: C33H29N3O5. Mole weight: 547.61. | |
Suramin Hexasodium Salt (Germanin, NSC 34936, SK 24728) Quick inquiry Where to buy Suppliers range | Sodium salt of Suramin, a hepatitis C virus NS3 helicase inhibitor. Also used in the treatment of arthritis due to problematic collagen.A P2x and P2y purinergic receptor antagonist that displays antitumor, antiangiogenic and antiparasitic activities. Inhibits sirtuin 1, sirtuin 5 and topoisomerase II. Inhibits the cell surface binding of various growth factors including PDGF, EGF, FGFa and FGFb. Blocks association of G protein alpha and b/g-subunits. Potent competitive inhibitor of reverse transcriptase and protects T lymphocytes against in vitro human immunodeficiency virus infection.Potent ATPase inhibitor. Potent competitive inhibitor of reverse transcriptase. Shows anti-HIV activity. Anticancer compound. Protein kinase C (PKC) inhibitor. Potent inhibitor of melanoma heparanase and tumor cell metastasis. Non-specific growth factors inhibitor (including PDGF, EGF, aFGF and bFGF). TGF-beta1 inhibitor. Topoisomerase I and II inhibitor. Interleukin-1 (IL-1) inhibitor. Interleukin-4 (IL-4) inhibitor. G protein inhibitor. P2X and P2Y purinergic receptor antagonist. Antiangiogenic. Potent VEGF inhibitor. Telomerase inhibitor. Shows adjuvant properties. Regulates ryanodine receptor. Direct adenylyl cyclase inhibitor. Protein synthesis inhibitor. SIRT1 (Sirtuin 1) and SIRT5 (Sirtuin 5) inhibitor. Immunosuppressive. Antifibrotic agent. Antiparasitic. Antiprotozoal. Athelmintic. Group: Biochemicals. Alternative Names: 8, 8'-[Carbonylbis[imino-3, 1-phenylenecarbonylimino (4-methyl-3, 1-phenylene) carbonylimino]]bis-1, 3, 5-naphthalenetrisulfonic Acid Sodium Salt (1:6); 8, 8'-[Carbonylbis[imino-3, 1-phenylenecarbonylimino (4-methyl-3, 1-phenylene) carbonylimino]]bis-1, 3, 5-naphthalenetrisulfonic Acid Hexasodium Salt; 8, 8'-[Ureylenebis[m-phenylenecarbonylimino (4-methyl-m-phenylene) carbonylimino]]di-1, 3, 5-naphthalenetrisulfonic Acid Hexasodium Salt; 309F; 8,8'-[Ureylenebis[m-phenylene carbonylimino (4-methyl-m-phenylene) carbonylimino]]di (1, 3, 5-naphthalenetrisulfonic Acid) Hexasodium Salt; Antrypol; BAY 205; Bayer 205; CI 1003; Fourneau 309; Germanin; Germanin (pharmaceutical); Hexasodium Sym.-bis(m-aminobenzoyl)-m-amino-p-methylbenzoyl-1-naphthylamino-4,6,8-trisulfonate) Carbamide; Moranyl; NF 060; Naganin; Naganine; Naphuride; Naphuride sodium; Sodium Suramin; Suramin Hexasodium; Suramin Sodium; Suramine Sodium. Grades: Highly Purified. CAS No. 129-46-4. Pack Sizes: 50mg, 100mg, 250mg. Molecular Formula: C??H??N?Na?O??S?, Molecular Weight: 1429.17. US Biological Life Sciences. | Worldwide |
tert-Butyl. (3- (5- (4-Aminophenyl sulfonamido) -6-methoxypyrazin-2-yl ) propyl ) carbamate Quick inquiry Where to buy Suppliers range | tert-Butyl (3- (5- (4-Aminophenyl sulfonamido) -6-methoxypyrazin-2-yl ) propyl ) carbamate is an intermediate in the synthesis of biotin-linked derivatives of Necrosulfonamide (N388600), a compound that specifically blocks necrosis downstream of receptor-interacting serine-threonine kinase 3 (RIP3) activation. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
TNP-470 (AGM-1470, O-(Chloroacetyl-carbamoyl)fumagillol, AGM1470, MetAP-2 Inhibitor II, MetAP2 Inhibitor II, Methionine Aminopeptidase 2 Inhibitor II, TNP470) Quick inquiry Where to buy Suppliers range | A cell-permeable Fumagillin analog that inhibits MetAP2, but not MetAP1, methionine aminopeptidase activity (IC50 = 1nM against human MetAP2), without affecting the inhibitory activity of MetAP2 against HRI- (heme-regulated inhibitor kinase) catalyzed eIF-2alpha phosphorylation. A potent endothelial cytostasis inducer (IC50 = 25 pM and 37 pM, respectively, against HUVEC and bovine BAEC) in vitro and an effective anti-angiogenesis agent in vivo (2-100mg/kg in mice and rats; s.c.). Group: Biochemicals. Grades: Highly Purified. CAS No. 129298-91-5. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
WH-4-023 Quick inquiry Where to buy Suppliers range | WH-4-023 is a potent and selective dual Lck/Src inhibitor with IC50 values of 2 nM and 6 nM for Lck and Src kinase respectively. In combination with PD 0325901, CHIR99021 and SB-590885, WH-4-023 was found to support self-renewal of naive human embryonic stem cells (hESCs). Synonyms: KIN001-112; KIN112; 2,6-dimethylphenyl (2,4-dimethoxyphenyl)(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)carbamate. Grades: >98%. CAS No. 837422-57-8. Molecular formula: C32H36N6O4. Mole weight: 568.67. |