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| Product | Description | |
|---|---|---|
| carboxylate reductase | A tungsten protein. Methyl viologen can act as acceptor. In the reverse direction, non-activated acids are reduced by reduced viologens to aldehydes, but not to the corresponding alcohols. Group: Enzymes. Synonyms: aldehyde:(acceptor) oxidoreductase. Enzyme Commission Number: EC 1.2.99.6. CAS No. 125008-36-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1234; carboxylate reductase; EC 1.2.99.6; 125008-36-8; aldehyde:(acceptor) oxidoreductase. Cat No: EXWM-1234. |  |
| 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH) | The enzyme is involved in the catabolism of D-lysine and D-proline in bacteria that belong to the Pseudomonas genus. In contrast to EC 1.5.1.1, 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H], which shows similar activity with NADPH and NADH, this enzyme is specific for NADPH. Group: Enzymes. Synonyms: Pyr2C reductase; 1,2-didehydropipecolate reductase; P2C reductase; 1,2-didehydropipecolic reductase; DELTA1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (ambiguous); L-pipecolate:NADP+ 2-oxidoreductase; DELTA1-piperideine-2-carboxylate reductase; Δ1-piperideine-2-carboxylate reductase. Enzyme Commission Number: EC 1.5.1.21. CAS No. 52037-88-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1503; 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH); EC 1.5.1.21; 52037-88-4; Pyr2C reductase; 1,2-didehydropipecolate reductase; P2C reductase; 1,2-didehydropipecolic reductase; DELTA1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (ambiguous); L-pipecolate:NADP+ 2-oxidoreductase; DELTA1-piperideine-2-carboxylate reductase; Δ1-piperideine-2-carboxylate reductase. Cat No: EXWM-1503. | |
| 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H] | The enzymes, characterized from the bacterium Azospirillum brasilense, is involved in trans-3-hydroxy-L-proline metabolism. In contrast to EC 1.5.1.21, 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH), which is specific for NADPH, this enzyme shows similar activity with NADPH and NADH. Group: Enzymes. Synonyms: Δ1-pyrroline-2-carboxylate reductase; DELTA1-pyrroline-2-carboxylate reductase; DELTA1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (ambiguous); AbLhpI; pyrroline-2-carboxylate reductase; L-proline:NAD(P)+ 2-oxidoreductase. Enzyme Commission Number: EC 1.5.1.1. CAS No. 9029-16-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1493; 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H]; EC 1.5.1.1; 9029-16-7; Δ1-pyrroline-2-carboxylate reductase; DELTA1-pyrroline-2-carboxylate reductase; DELTA1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (ambiguous); AbLhpI; pyrroline-2-carboxylate reductase; L-proline:NAD(P)+ 2-oxidoreductase. Cat No: EXWM-1493. | |
| 1-pyrroline-2-carboxylate reductase [NAD(P)H] | The enzyme from the bacterium Colwellia psychrerythraea is involved in trans-3-hydroxy-L-proline metabolism. In contrast to EC 1.5.1.1, 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H], which shows similar activity with 1-piperideine-2-carboxylate and 1-pyrroline-2-carboxylate, this enzyme is specific for the latter. While the enzyme is active with both NADH and NADPH, activity is higher with NADPH. Group: Enzymes. Enzyme Commission Number: EC 1.5.1.49. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1530; 1-pyrroline-2-carboxylate reductase [NAD(P)H]; EC 1.5.1.49. Cat No: EXWM-1530. | |
| pyrroline-5-carboxylate reductase | Also reduces 1-pyrroline-3-hydroxy-5-carboxylate to L-hydroxyproline. Group: Enzymes. Synonyms: proline oxidase; L-proline oxidase; 1-pyrroline-5-carboxylate reductase; NADPH-L-Δ1-pyrroline carboxylic acid reductase; L-proline-NAD(P)+ 5-oxidoreductase. Enzyme Commission Number: EC 1.5.1.2. CAS No. 9029-17-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1501; pyrroline-5-carboxylate reductase; EC 1.5.1.2; 9029-17-8; proline oxidase; L-proline oxidase; 1-pyrroline-5-carboxylate reductase; NADPH-L-Δ1-pyrroline carboxylic acid reductase; L-proline-NAD(P)+ 5-oxidoreductase. Cat No: EXWM-1501. | |
| 2-Cyclopropyl-4-phenyl-3-quinolinecarboxylic Acid Methyl Ester | 2-Cyclopropyl-4-phenyl-3-quinolinecarboxylic Acid Methyl Ester is one of pitavastatin impurities. Pitavastatin, also called as itavastatin, is a potent HMG-CoA reductase inhibitor. And studies showed that pitavastatin inhibited the activity of Rho-kinase depending on the inactivation of Rho by inhibiting the mevalonate pathway. Synonyms: Methyl 2-cyclopropyl-4-phenylquinoline-3-carboxylate; 2-Cyclopropyl-4-phenyl-3-quinolinecarboxylic Acid Methyl Ester; DTXSID00857071; AKOS022175172; SB72967; Methyl2-cyclopropyl-4-phenylquinoline-3-carboxylate. CAS No. 868536-53-2. Molecular formula: C20H17NO2. Mole weight: 303.35. |  |
| 2-enoate reductase | An iron-sulfur-flavoprotein (FAD). Acts (in the reverse direction) on a wide range of alkyl and aryl αβ-unsaturated carboxylate ions; but-2-enoate was the best substrate tested. Group: Enzymes. Synonyms: enoate reductase. Enzyme Commission Number: EC 1.3.1.31. CAS No. 70712-51-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1304; 2-enoate reductase; EC 1.3.1.31; 70712-51-5; enoate reductase. Cat No: EXWM-1304. | |
| 4-(4-Fluorophenyl)-2-cyclopropylquinoline-3-carboxylic Acid Methyl Ester | 4-(4-Fluorophenyl)-2-cyclopropylquinoline-3-carboxylic Acid Methyl Ester is an intermediate of Pitavastatin, which is a potent HMG-CoA reductase inhibitor for hypercholesterolemia (elevated cholesterol) and prevention of cardiovascular disease. Synonyms: 2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinecarboxylic Acid Methyl Ester; Methyl 2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinecarboxylate; Methyl 4-(4'-fluorophenyl)-2-(cyclopropyl)-3-quinolinecarboxylate; 3-Quinolinecarboxylic acid, 2-cyclopropyl-4-(4-fluorophenyl)-, methyl este; Pitavastatin Impurity 32. Grades: ≥95%. CAS No. 121659-86-7. Molecular formula: C20H16FNO2. Mole weight: 321.34. | |
| EBPC | EBPC is a potent and selective aldose reductase inhibitor. It is used to improve the cytotoxicity of anticancer reagents such as cisplatin and doxorubicin in HeLa cervical carcinoma cells via an increase in ERK activity. Synonyms: Ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate; 1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester; MFCD00179167; 1-benzyl-4-[ethoxy (hydroxy)methylidene]pyrrolidine-2, 3-dione. Grades: ≥99% by HPLC. CAS No. 4450-98-0. Molecular formula: C14H15NO4. Mole weight: 261.28. | |
| Finasteride EP Impurity B | An intermediate in the synthesis of Finasteride. Finasteride is a 4-azasteroid analog of testosterone that competitively blocks type II 5α-reductase activity with 100-fold greater affinity than for the type I enzyme. Synonyms: Dutasteride Ester Impurity; 3-Oxo-4-aza-5α-αndrost-1-ene-17β-carboxylic Acid Methyl Ester; Methyl 3-Oxo-4-aza-5α-androst-1-ene-17β-carboxylate. Grades: > 95%. CAS No. 103335-41-7. Molecular formula: C20H29NO3. Mole weight: 331.46. | |
| L-aminoadipate-semialdehyde dehydrogenase | (S)-2-amino-6-oxohexanoate undergoes a spontaneous dehydration forming the cyclic (S)-2,3,4,5-tetrahydropyridine-2-carboxylate, which serves as a substrate for the hydrogenation reaction. Group: Enzymes. Synonyms: aminoadipate semialdehyde dehydrogenase; 2-aminoadipate semialdehyde dehydrogenase; α-aminoadipate-semialdehyde dehydrogenase; α-aminoadipate reductase; 2-aminoadipic semialdehyde dehydrogenase; L-α-aminoadipate Δ-semialdehyde oxidoreductase; L-α-aminoadipate Δ-semialdehyde:NAD+ oxidoreductase; L-α-aminoadipate Δ-semialdehyde:. Enzyme Commission Number: EC 1.2.1.31. CAS No. 9067-87-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1138; L-aminoadipate-semialdehyde dehydrogenase; EC 1.2.1.31; 9067-87-2; aminoadipate semialdehyde dehydrogenase; 2-aminoadipate semialdehyde dehydrogenase; α-aminoadipate-semialdehyde dehydrogenase; α-aminoadipate reductase; 2-aminoadipic semialdehyde dehydrogenase; L-α-aminoadipate Δ-semialdehyde oxidoreductase; L-α-aminoadipate Δ-semialdehyde:NAD+ oxidoreductase; L-α-aminoadipate Δ-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase; L-2-aminoadipate 6-semialdehyde:NAD(P)+ 6-oxidoreductase. Cat No: EXWM-1138. | |
| Mevastatin Hydroxy Acid Sodium Salt | An active carboxylate of Mevastatin. It is a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase with hypocholesterolemic activity. It has been shown to be effective in reducing cholesterol synthesis in vivo, and thereby in lowering cholesterol levels in blood. Group: Biochemicals. Alternative Names: ( βR, δR, 1S, 2S, 8S, 8aR)-1, 2, 6, 7, 8, 8a-Hexahydro- β,δ-dihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-1-naphthaleneheptanoic Acid Sodium Salt;[1S-[1α( βS*, δS*), 2α, 8 β(R*),8aα]]-1,2,6,7,8,8a-Hexahydro- β,δ-dihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-1-naphthaleneheptanoic Acid Monosodium Salt; ( βR, δR, 1S, 2S, 8S, 8aR)-1, 2, 6, 7, 8, 8a-Hexahydro- β,δ-dihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-1-naphthaleneheptanoic Acid Monosodium Salt; ML 236B Sodium Salt. Grades: Highly Purified. CAS No. 99782-89-5. Pack Sizes: 25mg. US Biological Life Sciences. |  Worldwide |
| thiomorpholine-carboxylate dehydrogenase | The product is the cyclic imine of the 2-oxoacid corresponding to S-(2-aminoethyl)cysteine. In the reverse direction, a number of other cyclic unsaturated compounds can act as substrates, but more slowly. Group: Enzymes. Synonyms: ketimine reductase; ketimine-reducing enzyme. Enzyme Commission Number: EC 1.5.1.25. CAS No. 115232-54-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1507; thiomorpholine-carboxylate dehydrogenase; EC 1.5.1.25; 115232-54-7; ketimine reductase; ketimine-reducing enzyme. Cat No: EXWM-1507. | |
| Valerophenone | Valerophenone is an aromatic ketone that is often used as a tool in the study of various photochemical processes. It is also an inhibitor of the enzyme carbonyl reductase. Uses: Benzylhexahydropyrrolo[3,2-b]pyrrole-1(2h)-carboxylate (cas# 1251009-14-9) is a useful research chemical. Synonyms: 1-phenylpentan-1-one. Grades: > 95 %. CAS No. 1009-14-9. Molecular formula: C11H14O. Mole weight: 162.23. | |
| 1-((3R,5R)-6-carboxy-3,5-dihydroxyhexyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid | 1-((3R,5R)-6-carboxy-3,5-dihydroxyhexyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid is the impuritiy of Atorvastatin, a selective, competitive HMG-CoA reductase inhibitor. Synonyms: 1-[(3R,5R)-6-Carboxy-3,5-dihydroxyhexyl]-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid; (βR,δR)-3-Carboxy-5-(4-fluorophenyl)-β,δ-dihydroxy-2-(1-methylethyl)-4-phenyl-1H-Pyrrole-1-heptanoic Acid. CAS No. 1821498-27-4. Molecular formula: C27H30FNO6. Mole weight: 483.53. | |
| 2-hydroxypropyl-CoM lyase | Requires zinc. Acts on both enantiomers of chiral epoxyalkanes to form the corresponding (R)- and (S)-2-hydroxyalkyl-CoM adducts. The enzyme will function with some other thiols (e.g., 2-sulfanylethanol) as the nucleophile. Uses short-chain epoxyalkanes from C2 (epoxyethane) to C6 (1,2-epoxyhexane). This enzyme forms component I of a four-component enzyme system {comprising EC 4.4.1.23 (2-hydroxypropyl-CoM lyase; component I), EC 1.8.1.5 [2-oxopropyl-CoM reductase (carboxylating); component II], EC 1.1.1.268 [2-(R)-hydroxypropyl-CoM dehydrogenase; component III] and EC 1.1.1.269 [2-(S)-hydroxypropyl-CoM dehydrogenase; component IV]} that is involved in epoxyalkane carboxylation ...ission Number: EC 4.4.1.23. CAS No. 244301-07-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5325; 2-hydroxypropyl-CoM lyase; EC 4.4.1.23; 244301-07-3; epoxyalkane:coenzyme M transferase; epoxyalkane:CoM transferase; epoxyalkane:2-mercaptoethanesulfonate transferase; coenzyme M-epoxyalkane ligase; epoxyalkyl:CoM transferase; epoxypropane:coenzyme M transferase; epoxypropyl:CoM transferase; EaCoMT; 2-hydroxypropyl-CoM:2-mercaptoethanesulfonate lyase (epoxyalkane-ring-forming); (R)-2-hydroxypropyl-CoM 2-mercaptoethanesulfonate lyase (cyclizing; (R)-1,2-epoxypropane-forming). Cat No: EXWM-5325. | |
| 2-Iodo-3-Oxo-4-aza-5α-androst-17 β-carboxylic Acid | 2-Iodo-3-Oxo-4-aza-5α-androst-17 β-carboxylic Acid is a reactant in the synthesis of Duasteride (D735000), a dual inhibitor of 5α-reductase isoenzymes type 1 and 2; structurally related to Finasteride (F342000). Dutasteride is used in the treatment of benign prostatic hyperplasia. Group: Biochemicals. Grades: Highly Purified. CAS No. 140700-63-6. Pack Sizes: 10mg, 100mg. Molecular Formula: C19H28INO3, Molecular Weight: 445.33. US Biological Life Sciences. | Worldwide |
| 2-oxopropyl-CoM reductase (carboxylating) | Also acts on thioethers longer in chain length on the oxo side, e.g. 2-oxobutyl-CoM, but this portion must be attached to CoM (2-mercaptoethanesulfonate); no CoM analogs will substitute. This enzyme forms component II of a four-component enzyme system {comprising EC 4.4.1.23 (2-hydroxypropyl-CoM lyase; component I), EC 1.8.1.5 [2-oxopropyl-CoM reductase (carboxylating); component II], EC 1.1.1.268 [2-(R)-hydroxypropyl-CoM dehydrogenase; component III] and EC 1.1.1.269 [2-(S)-hydroxypropyl-CoM dehydrogenase; component IV]} that is involved in epoxyalkane carboxylation in Xanthobacter sp. strain Py2. Group: Enzymes. Synonyms: NADPH:2-(2-ketopropylthio)ethanesulfonate oxidoreductase/carboxylase; NADPH:2-ketopropyl-coenzyme M oxidoreductase/carboxylase. Enzyme Commission Number: EC 1.8.1.5. CAS No. 244301-63-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1649; 2-oxopropyl-CoM reductase (carboxylating); EC 1.8.1.5; 244301-63-1; NADPH:2-(2-ketopropylthio)ethanesulfonate oxidoreductase/carboxylase; NADPH:2-ketopropyl-coenzyme M oxidoreductase/carboxylase. Cat No: EXWM-1649. | |
| 2-(R)-hydroxypropyl-CoM dehydrogenase | The enzyme is highly specific for (R)-2-hydroxyalkyl thioethers of CoM, in contrast to EC 1.1.1.269, 2-(S)-hydroxypropyl-CoM dehydrogenase, which is highly specific for the (S)-enantiomer. This enzyme forms component III of a four-component enzyme system {comprising EC 4.4.1.23 (2-hydroxypropyl-CoM lyase; component I), EC 1.8.1.5 [2-oxopropyl-CoM reductase (carboxylating); component II], EC 1.1.1.268 [2-(R)-hydroxypropyl-CoM dehydrogenase; component III] and EC 1.1.1.269 [2-(S)-hydroxypropyl-CoM dehydrogenase; component IV]} that is involved in epoxyalkane carboxylation in Xanthobacter sp. strain Py2. Group: Enzymes. Synonyms: 2-(2-(R)-hydroxypropylthio)ethanesulfonate dehydrogenase. Enzyme Commission Number: EC 1.1.1.268. CAS No. 244301-33-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0174; 2-(R)-hydroxypropyl-CoM dehydrogenase; EC 1.1.1.268; 244301-33-5; 2-(2-(R)-hydroxypropylthio)ethanesulfonate dehydrogenase. Cat No: EXWM-0174. | |
| 2-(S)-hydroxypropyl-CoM dehydrogenase | The enzyme is highly specific for (S)-2-hydroxyalkyl thioethers of CoM, in contrast to EC 1.1.1.268, 2-(R)-hydroxypropyl-CoM dehydrogenase, which is highly specific for the (R)-enantiomer. This enzyme forms component IV of a four-component enzyme system {comprising EC 4.4.1.23 (2-hydroxypropyl-CoM lyase; component I), EC 1.8.1.5 [2-oxopropyl-CoM reductase (carboxylating); component II], EC 1.1.1.268 [2-(R)-hydroxypropyl-CoM dehydrogenase; component III] and EC 1.1.1.269 [2-(S)-hydroxypropyl-CoM dehydrogenase; component IV]} that is involved in epoxyalkane carboxylation in Xanthobacter sp. strain Py2. Group: Enzymes. Synonyms: 2-(2-(S)-hydroxypropylthio)ethanesulfonate dehydrogenase. Enzyme Commission Number: EC 1.1.1.269. CAS No. 369364-40-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0175; 2-(S)-hydroxypropyl-CoM dehydrogenase; EC 1.1.1.269; 369364-40-9; 2-(2-(S)-hydroxypropylthio)ethanesulfonate dehydrogenase. Cat No: EXWM-0175. | |
| 2-((Z)-5-((E)-2-methyl-3-phenylallylidene)-2,4-dioxothiazolidin-3-yl)acetic acid | An impurity of Epalrestat, a carboxylic acid-based inhibitor of aldose reductase. Synonyms: 2-[5-((2E)-2-methyl-3-phenylprop-2-enylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]a cetic acid. CAS No. 794510-29-5. Molecular formula: C15H13NO4S. Mole weight: 303.3. | |
| 3-Oxo-4-aza-11a-methoxy-5α-αndrost-1-ene-17 β-carboxylic Acid Methyl Ester | 3-Oxo-4-aza-11a-methoxy-5α-αndrost-1-ene-17 β-carboxylic Acid Methyl Ester is an intermediate in the synthesis of Finasteride (F342000), an inhibitor of 5α-reductase, the enzyme which converts testosterone to the more potent androgen, 5α-dihydrotestosterone. Group: Biochemicals. Grades: Highly Purified. CAS No. 1026013-15-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 3-Oxo-4-aza-5a-androst-1-ene-17b-carboxylic Acid | An intermediate in the synthesis of Finasteride, am onhibitor of 5a-reductase, the enzyme which converts testosterone to the more potent androgen, 5a-dihydrotestosterone. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| 3-Oxo-4-aza-5α-αndrost-1-ene-17 β-carboxylic Acid Methyl Ester | Finasteride impurity. A novel intermediate in the synthesis of Finasteride, a 5α-reductase inhibitor used for treatment of benign prostatic hyperplasia acne, seborrhea, female hirsutism, prostatitis, and prostatic carcinoma and other hyperandrogenetic related disorders. Group: Biochemicals. Alternative Names: (4aR, 4bS, 6aS, 7S, 9aS, 9bS, 11aR)-2, 4a, 4b, 5, 6, 6a, 7, 8, 9, 9a, 9b, 10, 11, 11a-Tetradecahydro-4a, 6a-dimethyl-2-oxo-. Grades: Highly Purified. CAS No. 103335-41-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 3-Oxo-4-azaandrosta-1,5,7-triene-17-carboxylic Acid Methyl Ester | 3-Oxo-4-azaandrosta-1,5,7-triene-17-carboxylic Acid Methyl Ester is an intermediate in the synthesis of Finasteride (F342000), an inhibitor of 5α-reductase, the enzyme which converts testosterone to the more potent androgen, 5α-dihydrotestosterone. Group: Biochemicals. Alternative Names: [4aR-(4aα,4b β, 6aα, 7α, 9a β)]-2, 4a, 4b, 5, 6, 6a, 7, 8, 9, 9a-Decahydro-4a, 6a-dimethyl-3-oxo-1H-indeno[5, 4-f]quinoline-7-carboxylic Acid Methyl Ester; (4aR, 4bS, 6aS, 7S, 9aR)-2, 4a, 4b, 5, 6, 6a, 7, 8, 9, 9a-Decahydro-4a, 6a-dimethyl-3-oxo-1H-indeno[5, 4-f]quinoline-7-carboxylic Acid Methyl Ester. Grades: Highly Purified. CAS No. 166896-63-5. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| (4S,6R)-6-(2-(tert-butoxy)-2-oxoethyl)-2,2-dimethyl-1,3-dioxane-4-carboxylic acid | An impurity of Rosuvastatin. Rosuvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. Synonyms: Rosuvastatin Impurity 42. CAS No. 2095786-11-9. Molecular formula: C13H22O6. Mole weight: 274.31. | |
| 5-Bromo-3-phenyl salicylic acid | The aldo-keto reductase (AKR) enzymes constitute a family of related NADPH-dependent oxidoreductases. 5-Bromo-3-phenyl salicylic acid selectively inhibits AKR1C1 (Ki = 140 nM) over AKR1C2 (K1 = 1.97 μM) and AKR1C3 (Ki = 21 μM). Synonyms: 5-Bromo-2-hydroxy-[1,1'-biphenyl]-3-carboxylic acid. Grades: ≥98%. CAS No. 99514-99-5. Molecular formula: C13H9BrO3. Mole weight: 293.1. | |
| (6aS,7S,9aR)-2,5,6,6a,7,8,9,9a-Octahydro-6a-methyl-2-oxo-1H-indeno[5,4-f]quinoline-7-carboxylic Acid Methyl Ester | (6aS,7S,9aR)-2,5,6,6a,7,8,9,9a-Octahydro-6a-methyl-2-oxo-1H-indeno[5,4-f]quinoline-7-carboxylic Acid Methyl Ester is an intermediate in the synthesis of Finasteride (F342000), an inhibitor of 5α-reductase, the enzyme which converts testosterone to the more potent androgen, 5α-dihydrotestosterone. Group: Biochemicals. Alternative Names: [6aS-(6aα,7α,9a β)]-2,5,6,6a,7,8,9,9a-Octahydro-6a-methyl-2-oxo-1H-indeno[5,4-f]quinoline-7-carboxylic Acid Methyl Ester; (17 β)-3-Oxo-4-azaestra-1,5,7,9-tetraene-17-carboxylic Acid Methyl Ester. Grades: Highly Purified. CAS No. 166896-66-8. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| [acetyl-CoA carboxylase]-phosphatase | Simultaneously dephosphorylates and activates EC 6.4.1.2 acetyl-CoA carboxylase. Acts similarly on EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase), EC 2.4.1.1 (phosphorylase), EC 2.4.1.11 [glycogen(starch) synthase], and dephosphorylates phosphoprotamine and 4-nitrophenyl phosphate. Not identical to EC 3.1.3.17 ([phosphorylase] phosphatase ) or EC 3.1.3.43 {[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase}. Group: Enzymes. Enzyme Commission Number: EC 3.1.3.44. CAS No. 77000-10-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3648; [acetyl-CoA carboxylase]-phosphatase; EC 3.1.3.44; 77000-10-3. Cat No: EXWM-3648. | |
| cholest-4-en-3-one 26-monooxygenase [(25R)-3-oxocholest-4-en-26-oate forming] | This enzyme, found in several bacterial pathogens, is involved in degradation of the host cholesterol. It catalyses the hydroxylation of the C-26 carbon, followed by oxidation of the alcohol to the carboxylic acid via the aldehyde intermediate, initiating the degradation of the alkyl side-chain of cholesterol. The products are exclusively in the (25R) conformation. The enzyme also accepts cholesterol as a substrate. cf. EC 1.14.13.141, cholest-4-en-3-one 26-monooxygenase. The enzyme can receive electrons from ferredoxin reductase in vitro, its natural electron donor is not known yet. Group: Enzymes. Synonyms: CYP142. Enzyme Commission Number: EC 1.14.13.221. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0824; cholest-4-en-3-one 26-monooxygenase [(25R)-3-oxocholest-4-en-26-oate forming]; EC 1.14.13.221; CYP142. Cat No: EXWM-0824. | |
| cholest-4-en-3-one 26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming] | This enzyme, found in several bacterial pathogens, is involved in degradation of the host's cholesterol. It catalyses the hydroxylation of the C-26 carbon, followed by oxidation of the alcohol to the carboxylic acid via the aldehyde intermediate, initiating the degradation of the alkyl side-chain of cholesterol. The products are exclusively in the (25S) configuration. It is a two-component system consisting of a P-450 (heme thiolate) oxygenase (Cyp125) and a ferredoxin reductase (most likely KshB, which is also a part of EC 1.14.13.142, 3-ketosteroid 9α-monooxygenase). The enzyme also accepts cholesterol as a substrate. cf. EC 1.14.13.221, cholest-4-en-3-one 27-monooxygenase. Group: Enzymes. Synonyms: CYP125; CYP125A1; cholest-4-en-3-one 27-monooxygenase (misleading); cholest-4-en-3-one,NADH:oxygen oxidoreductase (26-hydroxyl. Enzyme Commission Number: EC 1.14.13.141. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0741; cholest-4-en-3-one 26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming]; EC 1.14.13.141; CYP125; CYP125A1; cholest-4-en-3-one 27-monooxygenase (misleading); cholest-4-en-3-one,NADH:oxygen oxidoreductase (26-hydroxylating); cholest-4-en-3-one 26-monooxygenase (ambiguous). Cat No: EXWM-0741. | |
| crotonyl-CoA carboxylase/reductase | The reaction is catalysed in the reverse direction. This enzyme, isolated from the bacterium Rhodobacter sphaeroides, catalyses (E)-but-2-enoyl-CoA-dependent oxidation of NADPH in the presence of CO2. When CO2 is absent, the enzyme catalyses the reduction of (E)-but-2-enoyl-CoA to butanoyl-CoA, but with only 10% of maximal activity (relative to (E)-but-2-enoyl-CoA carboxylation). Group: Enzymes. Synonyms: CCR; crotonyl-CoA reductase (carboxylating). Enzyme Commission Number: EC 1.3.1.85. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1354; crotonyl-CoA carboxylase/reductase; EC 1.3.1.85; CCR; crotonyl-CoA reductase (carboxylating). Cat No: EXWM-1354. | |
| Dihydro Finasteride | The reduced product of Finasteride : a mechanism-based inhibitor of human prostate and skin steroid 5α-reductase. It forms an enzyme-bound NADP-dihydrofinasteride adduct during this inhibitory process. Group: Biochemicals. Alternative Names: (4aR, 4bS, 6aS, 7S, 9aS, 9bS, 11aR) -N- (1, 1-Dimethylethyl) hexadecahydro-4a, 6a-dimethyl-2-oxo-1H-indeno[5, 4-f]quinoline-7-carboxamide; Dihydroproscar; (5α,17 β)-N-(1,1-Dimethylethyl)-3-oxo-4-azaandrostane-17-carboxamide; [4aR-(4aα,4b β, 6aα, 7α, 9a β,9bα,11a β ) ]-N- (1, 1-Dimethylethyl) hexadecahydro-4a, 6a-dimethyl-2-oxo-1H-indeno[5, 4-f]quinoline-7-carboxamide; 1,2-Dihydrofinasteride; 3-Oxo-4-aza-5α-androstan-17 β-carboxylic acid N-(tert-butyl)amide; N-(tert-Butyl)-3-oxo-4-aza-5α-androstane-17 β-carboxamide. Grades: Highly Purified. CAS No. 98319-24-5. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| DT Diaphorase from human, Recombinant | DT Diaphorase is a flavoenzyme that catalyzes the oxidation of reduced di-and triphosphopyridine nucleotides. It contains one mole of FAD per mole of enzyme. The enzyme found in rat liver catalyzes the oxidation of NADH and NADPH by various dyes and quinones. The molecular weight is found to be approximately 48 kDa Da. The pH optimum of the enzyme purified from rat liver is found to be 5.0. It is a cytosolic enzyme that catalyzes the two-electron reduction of various quinones. It catalyzes the conversion of vitamin K to vitamin K hydroquinone for utilization in the post-translational γ-glutamyl carboxylation reactions. These reactions are necessary for several proteins involved in blood coagulation. Applications: Human dt diaphorase has been used in a study to assess the development of novel quinone phosphorodiamidate prodrugs. human dt diaphorase has also been used to investigate its crystal structure for the development of a model for its interaction with the cytotoxic prodrug 5-(aziridin-1-yl)-2,4-dinitrobenzamide (cb1954). Group: Enzymes. Synonyms: menadione reductase; phylloquinone reductase; quinone reductase; dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate, quinone); DT-diaphorase; flavoprotein NAD (P)H-q. Enzyme Commission Number: EC 1.6.99.2. Diaphorase. Mole weight: monomer mol wt 31 kDa. Storage: 2-8°C. F | |
| DT Diaphorase from rat, Recombinant | DT Diaphorase is a flavoenzyme that catalyzes the oxidation of reduced di-and triphosphopyridine nucleotides. It contains one mole of FAD per mole of enzyme. The enzyme found in rat liver catalyzes the oxidation of NADH and NADPH by various dyes and quinones. The molecular weight is found to be approximately 48 kDa Da. The pH optimum of the enzyme purified from rat liver is found to be 5.0. It is a cytosolic enzyme that catalyzes the two-electron reduction of various quinones. It catalyzes the conversion of vitamin K to vitamin K hydroquinone for utilization in the post-translational γ-glutamyl carboxylation reactions. These reactions are necessary for several proteins involved in blood coagulation. Applications: Dt diaphorase from rat has been used in a study to investigate the two-electron reduction of quinones by rat liver. dt diaphorase from rat has also been used in a study to investigate colon cancer chemopreventive efficacy of silibinin through perturbation of xenobiotic metabolizing enzymes. Group: Enzymes. Synonyms: menadione reductase; phylloquinone reductase; quinone reductase; dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate, quinone); DT-diaphorase; flavoprotein NAD (P)H-qui. Enzyme Commission Number: EC 1.6.99.2. Purity: ~90% (SDS-PAGE). Diaphorase. Mole weight: monomer mol wt 31 kDa. Storage: 2-8°C. Form | |
| EBPC | A highly specific aldose reductase inhibitor that has been shown to enhance HeLa cell sensitivity to chemotherapeutic drugs. Group: Biochemicals. Alternative Names: 2,5-Dihydro-4-hydroxy-5-oxo-1-(phenylmethyl)-1H-pyrrole-3-carboxylic Acid Ethyl Ester; 1-Benzyl-4-bydroxy-5-oxo-3-pyrroline-3-carboxylic Acid Ethyl Ester; NSC 229530; CP-10668. Grades: Highly Purified. CAS No. 4450-98-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Epalrestat Dimer | Dimer impurity of Epalrestat. Epalrestat is a carboxylic acid-based inhibitor of aldose reductase. Synonyms: Dimer of 5Z-[(2E)-2-methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-3-thiazolidineacetic acid. Grades: > 95%. Molecular formula: C30H26N2O6S4. Mole weight: 638.81. | |
| Epalrestat (E, E)-Isomer | A stereoisomer of Epalrestat. Epalrestat is a carboxylic acid-based inhibitor of aldose reductase. Synonyms: 2-((Z)-5-((Z)-2-Methyl-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid. Grades: > 95%. Molecular formula: C15H13NO3S2. Mole weight: 319.40. | |
| Epalrestat (E, Z)-Isomer | A stereoisomer of Epalrestat. Epalrestat is a carboxylic acid-based inhibitor of aldose reductase. Synonyms: (E,Z)-5-(2-Methyl-3-phenyl-2-propen-1-ylidene)-4-oxo-2-thioxo-3-thiazolidineacetic Acid. Grades: > 95%. Molecular formula: C15H13NO3S2. Mole weight: 319.40. | |
| Epalrestat (Z, Z)-Isomer | A stereoisomer of Epalrestat. Epalrestat is a carboxylic acid-based inhibitor of aldose reductase. Synonyms: 2-((Z)-5-((Z)-2-Methyl-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid. Grades: > 95%. Molecular formula: C15H13NO3S2. Mole weight: 319.40. | |
| Finasteride Carboxylic Acid | An impurity of Finasteride. Finasteride is a 4-azasteroid analog of testosterone that competitively blocks type II 5α-reductase activity with 100-fold greater affinity than for the type I enzyme. Synonyms: 2-Methyl-N-[[(5α,17β)-3-oxo-4-azaandrost-1-en-17-yl]carbonyl]alanine. Grades: > 95%. CAS No. 116285-37-1. Molecular formula: C23H34N2O4. Mole weight: 402.54. | |
| [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase | The enzyme is activated by AMP. EC 1.1.1.34, hydroxymethylglutaryl-CoA reductase (NADPH) is inactivated by the phosphorylation of the enzyme protein. Histones can also act as acceptors. The enzyme can also phosphorylate hepatic acetyl-CoA carboxylase (EC 6.4.1.2) and adipose hormone-sensitive lipase (EC 3.1.1.79). Thr-172 within the catalytic subunit (α-subunit) is the major site phosphorylated by the AMP-activated protein kinase kinase. GTP can act instead of ATP. Group: Enzymes. Synonyms: AMPK; AMP-activated protein kinase; HMG-CoA reductase kinase; β-hydro. Enzyme Commission Number: EC 2.7.11.31. CAS No. 172522-01-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3152; [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase; EC 2.7.11.31; 172522-01-9; AMPK; AMP-activated protein kinase; HMG-CoA reductase kinase; β-hydroxy-β-methylglutaryl-CoA reductase kinase; [hydroxymethylglutaryl-CoA reductase (NADPH2)] kinase; 3-hydroxy-3-methylglutaryl coenzyme A reductase kinase; 3-hydroxy-3-methylglutaryl-CoA reductase kinase; hydroxymethylglutaryl coenzyme A reductase kinase; hydroxymethylglutaryl coenzyme A reductase kinase (phosphorylating); hydroxymethylglutaryl-CoA reductase kinase; reductase kinase; STK29. Cat No: EXWM-3152. | |
| Lipid Metabolism Compound Library | A unique collection of 496 compounds targeting lipid metabolism, can be used for high-throughput screening (HTS) and high-content screening (HCS). - Covers several important targets, key components in lipid metabolism pathway, such as Acetyl-CoA Carboxylase?Acyltransferase?cholesteryl ester transfer protein (CETP)?FAAH?Fatty Acid Synthase (FASN)?HMG-CoA Reductase (HMGCR), etc. - Detailed compound information with structure, target, and biological activity description. - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L2510. Categories: Lipid Metabolism Compounds Libraries. |  |
| Native Porcine NAD(P)H Dehydrogenase (quinone) | DT Diaphorase is a flavoenzyme that catalyzes the oxidation of reduced di-and triphosphopyridine nucleotides. It contains one mole of FAD per mole of enzyme. The enzyme found in rat liver catalyzes the oxidation of NADH and NADPH by various dyes and quinones. The molecular weight is found to be approximately 48 kDa Da. The pH optimum of the enzyme purified from rat liver is found to be 5.0. It is a cytosolic enzyme that catalyzes the two-electron reduction of various quinones. It catalyzes the conversion of vitamin K to vitamin K hydroquinone for utilization in the post-translational γ-glutamyl carboxylation reactions. These reactions are necessary for several pr...hydrogenase; NAD (P)H menadione reductase; NAD (P)H-quinone dehydrogenase; NAD (P)H-quinone oxidoreductase; NAD (P)H: (quinone-acceptor)oxidoreductase. CAS No. 9032-20-6. Diaphorase. Activity: >25 U/mg. Stability: At +2 to +8°C within specification range for 12 months. Appearance: Yellow suspension in ammonium sulfate, 3.2 mol/l. Source: Porcine heart. Species: Porcine. menadione reductase; phylloquinone reductase; quinone reductase; dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate, quinone); DT-diaphorase; flavoprotein NAD (P)H-quinone reductase; menadione oxidoreductase; NAD (P)H dehydrogenase; NAD (P)H menadione reductase; NAD (P)H-quinone dehydro | |
| tyrosine 3-monooxygenase | The active centre contains mononuclear iron(II). The enzyme is activated by phosphorylation, catalysed by EC 2.7.11.27, [acetyl-CoA carboxylase] kinase. The 4a-hydroxytetrahydrobiopterin formed can dehydrate to 6,7-dihydrobiopterin, both spontaneously and by the action of EC 4.2.1.96, 4a-hydroxytetrahydrobiopterin dehydratase. The 6,7-dihydrobiopterin can be enzymically reduced back to tetrahydrobiopterin, by EC 1.5.1.34 (6,7-dihydropteridine reductase), or slowly rearranges into the more stable compound 7,8-dihydrobiopterin. Group: Enzymes. Synonyms: L-tyrosine hydroxylase; tyrosine 3-hydroxylase; tyrosine hydroxylase. Enzyme Commission Number: EC 1.14.16.2. CAS No. 9036-22-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0954; tyrosine 3-monooxygenase; EC 1.14.16.2; 9036-22-0; L-tyrosine hydroxylase; tyrosine 3-hydroxylase; tyrosine hydroxylase. Cat No: EXWM-0954. | |
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