Caspase Inhibitor Suppliers USA
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Product | Description | |
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Caspase Inhibitor I Quick inquiry Where to buy Suppliers range | Z-VAD(OMe)-FMK (Z-Val-Ala-Asp(OMe)-FMK) is a cell-permeable and irreversible pan-caspase inhibitor. Z-VAD(OMe)-FMK is an ubiquitin carboxy-terminal hydrolase L1 (UCHL1) inhibitor. Z-VAD(OMe)-FMK irreversibly modifies UCHL1 by targeting the active site of UCHL1. Uses: Peptide Inhibitors. CAS No. 187389-52-2. Product ID: R1807. | |
Caspase Inhibitor I, Biotin Conjugate Quick inquiry Where to buy Suppliers range | The Caspase Inhibitor I, Biotin Conjugate controls the biological activity of Caspase. This small molecule/inhibitor is primarily used for Cancer applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 1MG. Mole weight: 672.81. Catalog: IAR42415295. | |
Caspase Inhibitor II, Cell-Permeable Quick inquiry Where to buy Suppliers range | The Caspase Inhibitor II, Cell-Permeable controls the biological activity of Caspase. This small molecule/inhibitor is primarily used for Cancer applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 1MG. Mole weight: 1827.25. Catalog: IAR42415307. Assay: ≥95% (HPLC). | |
Caspase Inhibitor III - CAS 634911-80-1 Quick inquiry Where to buy Suppliers range | The Caspase Inhibitor III, also referenced under CAS 634911-80-1, controls the biological activity of Caspase. This small molecule/inhibitor is primarily used for Cancer applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 634911-80-1. Pack Sizes: 250μG, 1MG. Mole weight: 263.26. Catalog: AP634911801. | |
Group III Caspase Inhibitor I Quick inquiry Where to buy Suppliers range | The Group III Caspase Inhibitor I controls the biological activity of Group III caspases (caspase-6, -8, -9, and -10). This small molecule/inhibitor is primarily used for Cancer applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 1MG. Mole weight: 610.63. Catalog: IAR42415321. | |
InSolution Caspase Inhibitor I Quick inquiry Where to buy Suppliers range | The Caspase Inhibitor I controls the biological activity of Caspase. This small molecule/inhibitor is primarily used for Cancer applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 1MG. Mole weight: 467.49. Catalog: IAR42415327. | |
InSolution Caspase Inhibitor VI Quick inquiry Where to buy Suppliers range | The Caspase Inhibitor VI, also referenced under CAS 161401-82-7, controls the biological activity of Caspase. This small molecule/inhibitor is primarily used for Cancer applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 1MG. Mole weight: 453.46. Catalog: IAR42415312. Assay: ≥95% (TLC). | |
Caspase-12 Inhibitor Z-ATAD-FMK Quick inquiry Where to buy Suppliers range | Cell permeable peptide inhibitor of Caspase 12 that irreversibly inhibits caspase-12 and related caspase activity. Uses: Peptide Inhibitors. Product ID: R1031. | |
Caspase-13 Inhibitor Z-LEED-FMK Quick inquiry Where to buy Suppliers range | A synthetic peptide inhibitor that inhibits caspase-13 and related caspase activity. FMK inhibitors are irreversible and non-toxic, and can be used in both in vivo and in vitro studies. Uses: Peptide Inhibitors. Product ID: R1027. | |
Caspase-1 Inhibitor I, Cell-Permeable Quick inquiry Where to buy Suppliers range | The Caspase-1 Inhibitor I, Cell-Permeable controls the biological activity of Caspase-1. This small molecule/inhibitor is primarily used for Cancer applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 1MG. Mole weight: 1990.43. Catalog: IAR42415323. Assay: ≥97% (HPLC). | |
Caspase-1 Inhibitor VI Quick inquiry Where to buy Suppliers range | Caspase-1 Inhibitor VI, Z-YVAD-FMK, is a potent, cell-permeable, and irreversible inhibitor of caspase-1, caspase-4, and caspase-5. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 250μG, 1MG. Mole weight: 630.66. Catalog: IAR42415298. Assay: ≥95% (HPLC); ≥95% (TLC). | |
Caspase-2 Inhibitor I Quick inquiry Where to buy Suppliers range | The Caspase-2 Inhibitor I controls the biological activity of Caspase-2. This small molecule/inhibitor is primarily used for Cancer applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 250μG, 1MG. Mole weight: 695.73. Catalog: IAR42415296. Assay: ≥95% (HPLC); ≥95% (TLC). | |
Caspase-2 Inhibitor Z-VDVAD-FMK Quick inquiry Where to buy Suppliers range | Z-VDVAD-FMK is a synthetic peptide that irreversibly inhibits the activity of caspase-2. It attenuates oxyhemoglobin-induced cleavage of PARP and apoptosis in endothelial cells. Z-VDVAD-FMK can be used for both in vitro and in vivo studies. Uses: Peptide Inhibitors. CAS No. 210344-95-9. Product ID: R1111. | |
Caspase-3 Inhibitor I, Cell-Permeable Quick inquiry Where to buy Suppliers range | The Caspase-3 Inhibitor I, Cell-Permeable controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 1MG. Mole weight: 2000.38. Catalog: IAR42415315. Assay: ≥97% (HPLC). | |
Caspase-3 Inhibitor VII - CAS 745046-84-8 Quick inquiry Where to buy Suppliers range | The Caspase-3 Inhibitor VII, also referenced under CAS 745046-84-8, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 745046-84-8. Pack Sizes: 10MG. Mole weight: 447.46. Catalog: AP745046848. Assay: ≥95% (HPLC). | |
Caspase-4 Inhibitor I - CAS 402832-01-3 Quick inquiry Where to buy Suppliers range | The Caspase-4 Inhibitor I, also referenced under CAS 402832-01-3, controls the biological activity of Caspase-4. This small molecule/inhibitor is primarily used for Cancer applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 402832-01-3. Pack Sizes: 1MG. Mole weight: 500.54. Catalog: AP402832013. Assay: ≥95% (HPLC). | |
Caspase-4 Inhibitor I, Cell-Permeable Quick inquiry Where to buy Suppliers range | The Caspase-4 Inhibitor I, Cell-Permeable controls the biological activity of Caspase-4. This small molecule/inhibitor is primarily used for Cancer applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 1MG. Mole weight: 1998.45. Catalog: IAR42415303. Assay: ≥97% (HPLC). | |
Caspase-5 Inhibitor I Quick inquiry Where to buy Suppliers range | Z-WEHD-FMK is a cell-permeable, potent, irreversible caspase-5 inhibitor, that also inhibits the activity of Caspase 1, 4, and 8. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 1MG. Mole weight: 763.77. Catalog: IAR42415300. | |
Caspase-6 Inhibitor I Quick inquiry Where to buy Suppliers range | The Caspase-6 Inhibitor I controls the biological activity of Caspase-6. This small molecule/inhibitor is primarily used for Cancer applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 250μG, 1MG. Mole weight: 652.71. Catalog: IAR42415302. Assay: ≥90% (TLC). | |
Caspase-6 Inhibitor II, Cell-Permeable Quick inquiry Where to buy Suppliers range | The Caspase-6 Inhibitor II, Cell-Permeable controls the biological activity of Caspase-6. This small molecule/inhibitor is primarily used for Cancer applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 1MG. Mole weight: 1998.45. Catalog: IAR42415304. Assay: ≥97% (HPLC). | |
Caspase-6 Inhibitor XII, pep419 Quick inquiry Where to buy Suppliers range | The Caspase-6 Inhibitor XII, pep419 controls the biological activity of Caspase-6. This small molecule/inhibitor is primarily used for Cancer applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 5MG. Mole weight: 2268.59. Catalog: IAR42415309. Assay: ≥95% (HPLC). | |
Caspase-6 Inhibitor Z-VEID-FMK Quick inquiry Where to buy Suppliers range | Z-VEID-FMK is a synthetic peptide that irreversibly inhibits activity of VEID-dependent caspases (e.g., caspase-6). The inhibitor is designed as a methyl ester to facilitate cell permeability. Can be used for both in vitro and in vivo studies. Uses: Peptide Inhibitors. Product ID: R1109. | |
Caspase-8 Inhibitor I, Cell-Permeable Quick inquiry Where to buy Suppliers range | The Caspase 8 Inhibitor I, Cell-Permeable controls the biological activity of Caspase-8. This small molecule/inhibitor is primarily used for Cancer applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 1MG. Mole weight: 2000.42. Catalog: IAR42415431. Assay: ≥95% (HPLC). | |
Caspase-8 Inhibitor II Quick inquiry Where to buy Suppliers range | The Caspase-8 Inhibitor II controls the biological activity of Caspase-8. This small molecule/inhibitor is primarily used for Cancer applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 250μG, 1MG. Mole weight: 654.68. Catalog: IAR42415430. | |
Caspase-8 Inhibitor, Q-IETD-OPh (Q-IE(OMe)-TD(OMe)-OPh, Quinolyl-Ile-Glu(OMe)-Thr-Asp(OMe)-OPh) Quick inquiry Where to buy Suppliers range | A second-generation capase-8 inhibitor that is potent, cell permeable, irreversible and nontoxic. Group: Biochemicals. Grades: Purified. Pack Sizes: 3mg. US Biological Life Sciences. | Worldwide |
Caspase-9 Inhibitor II, Cell-Permeable Quick inquiry Where to buy Suppliers range | The Caspase-9 Inhibitor II, Cell-Permeable controls the biological activity of Caspase-9. This small molecule/inhibitor is primarily used for Cancer applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 1MG. Mole weight: 2036.46. Catalog: IAR42415305. Assay: ≥95% (HPLC). | |
caspase 9 inhibitor iii Quick inquiry Where to buy Suppliers range | caspase 9 inhibitor iii. Uses: API. CAS No. 403848-57-7. Product ID: HB00092. | |
Caspase-9 Inhibitor III Quick inquiry Where to buy Suppliers range | Caspase-9 Inhibitor III is a potent and irreversible inhibitor of caspase-9 with cardioprotective effects. Caspase inhibitors play an important role in investigating biological processes. Caspase-9 can reduce infarct size, lactate dehydrogenase (LDH) and creatine kinase (CK) release, and DNA smearing induced by ischemia and reperfusion in isolated rat hearts. The caspase family of proteins function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Synonyms: Ac-LEHD-CMK. Grades: 98%. CAS No. 403848-57-7. Molecular formula: C24H35ClN6O9. Mole weight: 587.02. | |
Caspase-9 Inhibitor III - CAS 403848-57-7 Quick inquiry Where to buy Suppliers range | The Caspase-9 Inhibitor III, also referenced under CAS 403848-57-7, controls the biological activity of Caspase-9. This small molecule/inhibitor is primarily used for Cancer applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 403848-57-7. Pack Sizes: 1MG. Mole weight: 587.02. Catalog: AP403848577. Assay: ≥95% (HPLC). | |
Caspase-9 Inhibitor, Q-LEHD-OPh (Q-LE(OMe)-HD(OMe)-OPh, Quinolyl-Leu-Glu(OMe)-His-Asp(OMe)-OPh) Quick inquiry Where to buy Suppliers range | A second-generation capase-9 inhibitor that is potent, cell permeable, irreversible and nontoxic. Group: Biochemicals. Grades: Purified. Pack Sizes: 3mg. US Biological Life Sciences. | Worldwide |
Caspase-9 Inhibitor Z-LEHD-FMK Quick inquiry Where to buy Suppliers range | Caspase-9 Inhibitor Z-LEHD-FMK is a synthetic peptide that irreversibly inhibits caspase-9 and related caspase activity. It is applied for study of apoptosis. Uses: Peptide Inhibitors. Product ID: R0811. | |
InSolution Caspase-3 Inhibitor I, Cell-Permeable Quick inquiry Where to buy Suppliers range | The Caspase-3 Inhibitor I, Cell-Permeable controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 1MG. Mole weight: 2000.38. Catalog: IAR42415316. Assay: ≥90% (HPLC). | |
InSolution Caspase-3 Inhibitor II Quick inquiry Where to buy Suppliers range | The Caspase-3 Inhibitor II controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 250μG. Mole weight: 668.66. Catalog: IAR42415318. | |
InSolution Caspase-8 Inhibitor II Quick inquiry Where to buy Suppliers range | The Caspase-8 Inhibitor II controls the biological activity of Caspase-8. This small molecule/inhibitor is primarily used for Cancer applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 250μG. Mole weight: 654.68. Catalog: IAR42415432. | |
InSolution Caspase-9 Inhibitor I Quick inquiry Where to buy Suppliers range | The Caspase-9 Inhibitor I controls the biological activity of Caspase-9. This small molecule/inhibitor is primarily used for Cancer applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 250μG. Mole weight: 690.72. Catalog: IAR42415310. | |
Caspase-1/ICE Inhibitor Z-WEHD-FMK Quick inquiry Where to buy Suppliers range | Z-WEHD-FMK is an inhibitor of caspase-1, caspase-5 and cathepsin B, which can inhibit cell apoptosis in a variety of biological systems. Synonyms: CASPASE-1 INHIBITOR TFA SALT; Z-WEHD-FMK-TFA; Z-TRP-GLU(OME)-HIS-ASP(OME)-FMK-TFA. Grades: >99%. CAS No. 210345-00-9. Molecular formula: C37H42FN7O11. Mole weight: 763.78. | |
Caspase-1/ICE Inhibitor Z-WEHD-FMK Quick inquiry Where to buy Suppliers range | Z-WEHD-FMK is an effective, cell-permeable and irreversible inhibitor of caspase-1, caspase-5 and cathepsin B (IC50 = 6 µM). It can inhibit apoptosis in multiple biological systems. Uses: Peptide Inhibitors. CAS No. 210345-00-9. Product ID: R0900. | |
Caspase-3/7 Inhibitor I Quick inquiry Where to buy Suppliers range | Caspase-3/7 inhibitor I is a potent, reversible, isatin sulfonamide-based inhibitor of caspase-3 (Ki(app) = 60 nM; IC50 = 120 nM) and caspase-7 (Ki(app) = 170 nM). It is a weaker inhibitor of caspase-9 with Ki(app) of 3.1 μM and caspase-1, caspase-2, caspase-4, caspase-6, and caspase-8 (Ki(app)s ≥25 μM). The basis for the unique selectivity of this compound for caspases 3 and 7 involves the recognition of three distinct hydrophobic residues in the S2 pocket surrounding the catalytic cysteine residue. Grades: ≥98%. CAS No. 1110670-49-9. Molecular formula: C14H16N2O5S. Mole weight: 324.4. | |
Caspase-3/7 Inhibitor II - CAS 775289-20-8 Quick inquiry Where to buy Suppliers range | The Caspase-3/7 Inhibitor II, also referenced under CAS 775289-20-8, controls the biological activity of Caspase-3/7. This small molecule/inhibitor is primarily used for Cancer applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 775289-20-8. Pack Sizes: 1MG. Mole weight: 501.49. Catalog: AP775289208. | |
10Panx Quick inquiry Where to buy Suppliers range | Panx-1 mimetic inhibitory peptide that blocks pannexin-1 gap junctions. Inhibits P2X7-mediated dye uptake, ATP-mediated IL-1 β release and caspase-1 activation without altering membrane current in macrophages in vitro. Also blocks activation of NMDA receptor secondary currents (I2nd) by >70%. Group: Biochemicals. Grades: Highly Purified. CAS No. 955091-53-9. Pack Sizes: 1mg. Molecular Formula: C58H79N15O16, Sequence: WRQAAFVDSY. US Biological Life Sciences. | Worldwide |
10Panx Quick inquiry Where to buy Suppliers range | 10Panx is a mimetic inhibitory peptide of panx1, which blocks pannexin-1 gap junctions, inhibits p2x7-mediated dye uptake, atp-mediated il-1β release and caspase-1 activation, but does not alter membrane current in macrophages in vitro. Uses: Peptide Inhibitors. CAS No. 955091-53-9. Product ID: R0961. | |
2-Bromoaniline-d4 Quick inquiry Where to buy Suppliers range | 2-Bromoaniline-d4 is the labeled analogue of 2-Bromoaniline (B679950), a reagent used in the synthesis of substituted 2-carboxanilides as herbicides and antibacterials. Also used in the synthesis of benzisothiazol-3-one derivatives as caspase-3 inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 1643564-99-1. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C6H2D4BrN, Molecular Weight: 176.05. US Biological Life Sciences. | Worldwide |
(2-Bromoethyl)benzene Quick inquiry Where to buy Suppliers range | (2-Bromoethyl)benzene is used in the synthesis of sulforaphane derivatives used as potential antitumor agents. As well, used in the synthesis of 1,2-benzisothiazol-3-one derivatives as potent caspase-3-inhibitors. Group: Biochemicals. Alternative Names: (2-Bromoethyl)benzene; 1-Bromo-2-phenylethane; 1-Phenyl-2-bromoethane; 2-Bromo-1-phenylethane; 2-Phenethyl Bromide; 2-Phenyl-1-bromoethane; 2-Phenylbromoethane; 2-Phenylethyl Bromide; NSC 33926; Phenethyl Bromide; Phenylethyl Bromide; β-Bromoethylbenzene; β-Phenethyl Bromide; β-Phenylethyl Bromide. Grades: Highly Purified. CAS No. 103-63-9. Pack Sizes: 50g. US Biological Life Sciences. | Worldwide |
3,3'-Diamino-4'-methoxyflavone, DD1 (3-amino-2-(3-amino-4-methoxyphenyl)-4H-chromen-4-one, p76S6 Inhibitor, DD1, Proteasome Inhibitor, DD1) Quick inquiry Where to buy Suppliers range | A cell-permeable flavone derivative that arrests the proliferation of acute myeloid leukemia cells (NB4, U937, HL-60, OCI AML3), in a dose and time-dependent manner (optimum at ~20uM and 96h) and blocks the colony formation in samples from acute myeloid leukemia patients, without affecting normal blood cells. Shown to reduce mitochondrial membrane potential and Bad phosphorylation (at Ser136), induce Bax and caspase 3, 8, and 9 activation in U937 cells. Does not affect the phosphorylation of Akt1, but significantly reduces the expression and phosphorylation of p70S6 kinase in U937 cells. Reported to inhibit the chymotrypsin-like activity of proteasome (IC50 = 2.0uM) and this effect is synergistic with bortezomib. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
3-(5-Amino-3-methyl-1H-pyrazol-1-yl)-Benzoic Acid-d4 Hydrochloride Quick inquiry Where to buy Suppliers range | Isotope labelled 3-(5-Amino-3-methyl-1H-pyrazol-1-yl)-Benzoic Acid is a reagent used in the synthesis of quinoline derivatives used as caspase-3 inhibitors. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C11H8D4ClN3O2, Molecular Weight: 257.71. US Biological Life Sciences. | Worldwide |
3-(5-Amino-3-methyl-1H-pyrazol-1-yl)-Benzoic Acid Hydrochloride Quick inquiry Where to buy Suppliers range | 3-(5-Amino-3-methyl-1H-pyrazol-1-yl)-Benzoic Acid is a reagent used in the synthesis of quinoline derivatives used as caspase-3 inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 1620390-43-3. Pack Sizes: 100mg, 1g. Molecular Formula: C11H12ClN3O2, Molecular Weight: 253.68. US Biological Life Sciences. | Worldwide |
AC 187 Quick inquiry Where to buy Suppliers range | Potent and selective amylin receptor antagonist that displays 38-fold and 400-fold selectivity over calcitonin and CGRP receptors respectively. Through attenuating the activation of initiator and effector caspases in vitro, it blocks amyloid β-induced neurotoxicity. It can increase glucagon secretion, accelerate gastric emptying, change plasma glucose levels and increase food intake in vivo. Uses: Peptide Inhibitors. CAS No. 151804-77-2. Product ID: R0952. | |
Ac-AAVALLPAVLLALLAP-DEVD-CHO trifluoroacetate salt Quick inquiry Where to buy Suppliers range | Ac-AAVALLPAVLLALLAP-DEVD-CHO is a composite of Ac-DEVD-CHO, a peptide inhibitor of caspase-3 and -7, and a cell-permeable hydrophobic sequence derived from K-FGF. Synonyms: Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Glu-Val-Asp-CHO; Ac-AAVALLPAVLLALLAP-DEVD-aldehyde; Ac-AAVALLPAVLLALLAPDEVD-CHO; ?Caspase-3 Inhibitor I; DEVD-CHO-CPP 32. Grades: ≥95%. Molecular formula: C94H158N20O27·xCF3COOH. Mole weight: 2000.42. | |
Ac-AAVALLPAVLLALLAP-IETD-CHO trifluoroacetate salt Quick inquiry Where to buy Suppliers range | Ac-AAVALLPAVLLALLAP-IETD-CHO is a composite of Ac-IETD-CHO, a peptide inhibitor of caspase-8, and a cell-permeable hydrophobic sequence derived from K-FGF. Synonyms: Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Ile-Glu-Thr-Asp-CHO; Caspase-8 Inhibitor I. Grades: ≥95%. Molecular formula: C95H162N20O26·xCF3COOH. Mole weight: 2000.40. | |
Ac-AAVALLPAVLLALLAP-VAD-CHO trifluoroacetate salt Quick inquiry Where to buy Suppliers range | Ac-AAVALLPAVLLALLAP-VAD-CHO is a composite of Ac-VAD-CHO, a non-selective caspase inhibitor, and a cell-permeable hydrophobic sequence derived from K-FGF. Synonyms: Caspase Inhibitor II; Ac-AAVALLPAVLLALLAP-VAD-aldehyde; Ac-AAVALLPAVLLALLAPVAD-CHO. Grades: ≥95%. Molecular formula: C88H151N19O22·xCF3COOH. Mole weight: 1827.3. | |
Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Ile-Glu-Thr-Asp-aldehyde Quick inquiry Where to buy Suppliers range | Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Ile-Glu-Thr-Asp-aldehyde, a potent and reversible caspase-8 inhibitor, enables cell permeability by linking to a nonpolar CPP corresponding to the Kaposi fibroblast growth factor (FGF) signaling peptide sequence. Synonyms: Caspase-8 Inhibitor I, Cell Permeable; N-Acetyl-L-alanyl-L-alanyl-L-valyl-L-alanyl-L-leucyl-L-leucyl-L-prolyl-L-alanyl-L-valyl-L-leucyl-L-leucyl-L-alanyl-L-leucyl-L-leucyl-L-alanyl-L-prolyl-L-isoleucyl-L-α-glutamyl-N-[(2S)-1-carboxy-3-oxo-2-propanyl]-L-threoninamide; N-Acetyl-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Ile-Glu-Thr-Asp-al; L-Threoninamide, N-acetyl-L-alanyl-L-alanyl-L-valyl-L-alanyl-L-leucyl-L-leucyl-L-prolyl-L-alanyl-L-valyl-L-leucyl-L-leucyl-L-alanyl-L-leucyl-L-leucyl-L-alanyl-L-prolyl-L-isoleucyl-L-α-glutamyl-N-[(1S)-2-carboxy-1-formylethyl]-. Grades: ≥95%. CAS No. 886462-83-5. Molecular formula: C95H162N20O26. Mole weight: 2000.42. | |
Ac-DEVD-CHO Quick inquiry Where to buy Suppliers range | Ac-DEVD-CHO is a potent aldehyde inhibitor of Group II caspases with Ki values of 0.2 nM and 0.3 nM for for caspase-3 and caspase-7, respectively. Weak inhibition for caspase-2. Uses: Cysteine proteinase inhibitors. Synonyms: N-acetyl-asp-glu-val-asp-al; Ac-Asp-Glu-Val-Asp-Aldehyde; L-Valinamide,N-acetyl-L-a-aspartyl-L-a-glutamyl-N-(2-carboxy-1-formylethyl)-. Grades: 95 %. CAS No. 169332-60-9. Molecular formula: C20H30N4O11. Mole weight: 502.47. | |
Ac-DEVD-CHO acetate Quick inquiry Where to buy Suppliers range | Ac-DEVD-CHO acetate is a specific inhibitor of Caspase-3. Synonyms: Caspase-3 Inhibitor I; N-acetyl-asp-glu-val-asp-al acetate; Ac-Asp-Glu-Val-Asp-al acetate; Ac-DEVD-al.CH3CO2H; L 761191 acetate; MF 191 acetate; N-acetyl-L-alpha-aspartyl-L-alpha-glutamyl-L-valyl-L-aspart-1-al acetate; N-Acetyl-L-α-aspartyl-L-α-glutamyl-N-[(1S)-2-carboxy-1-formylethyl]-L-valinamide acetate. Grades: ≥95%. Molecular formula: C22H34N4O13. Mole weight: 562.52. | |
Ac-DEVD-CMK Quick inquiry Where to buy Suppliers range | Ac-DEVD-CMK is a cell-permeable, and irreversible inhibitor of caspase-3 as well as caspase-6, -7, -8, and -10. It is commonly used at concentrations up to 100 μM to examine the role of caspase-3-dependent apoptosis in biological systems. Synonyms: Ac-Asp-Glu-Val-Asp-chloromethylketone; Caspase-3 Inhibitor III; N-acetyl-Asp-Glu-Val-Asp-chloromethylketone; N-Acetyl-L-α-aspartyl-L-α-glutamyl-N-[(2S)-1-carboxy-4-chloro-3-oxo-2-butanyl]-L-valinamide; (2S,5S,8S,11S)-8-(2-carboxyethyl)-11-(carboxymethyl)-2-(2-chloroacetyl)-5-isopropyl-4,7,10,13-tetraoxo-3,6,9,12-tetraazatetradecane-1-carboxylic acid. Grades: ≥98%. CAS No. 285570-60-7. Molecular formula: C21H31ClN4O11. Mole weight: 550.95. | |
Ac-DMQD-CHO trifluoroacetate salt Quick inquiry Where to buy Suppliers range | Ac-DMQD-CHO is a peptide inhibitor of caspase-3 (IC50 = 39 nM). It is selective for caspase-3 over caspase-1 and caspase-8 (IC50s = 148 and 1,100 nM, respectively). Ac-DMQD-CHO inhibits apoptosis induced by camptothecin in immortalized human T/C 28a4 chondrocytes and primary human chondrocytes. In vivo, Ac-DMQD-CHO (1 mg/kg, i.v.) reduces the number of apoptotic cells, cavitation, and demyelination in a rat model of traumatic injury to the spinal cord. Synonyms: Ac-Asp-Met-Gln-Asp-CHO; Caspase-3 Inhibitor. Grades: ≥95%. Molecular formula: C20H31N5O10S·xCF3COOH. Mole weight: 533.6. | |
Ac-FLTD-CMK Quick inquiry Where to buy Suppliers range | Ac-FLTD-CMK is a potent and selective inhibitor of caspases 1, 5 and 4 (IC50 values=46.7 nM, 0.33 μM, 1.49 μM, respectively) that inhibits gasdermin D (GSDMD) cleavage. Synonyms: N-acetyl-Phe-Leu-Thr-Asp-chloromethylketone. Grades: >95%. CAS No. 2376255-48-8. Molecular formula: C26H37ClN4O8. Mole weight: 569.05. | |
Ac-IETD-CHO trifluoroacetate salt Quick inquiry Where to buy Suppliers range | Ac-IETD-CHO is an inhibitor of caspase-8 (IC50 = 5 nM). It inhibits fluticasone propionate-induced increases in apoptosis in peripheral blood T-cells isolated from patients with asthma when used at a concentration 60 μM. Synonyms: Ac-Ile-Glu-Thr-Asp-CHO; Caspase-8 Inhibitor. Grades: ≥95%. CAS No. 191338-86-0. Molecular formula: C21H34N4O10·xCF3COOH. Mole weight: 502.52. | |
Ac-LEVD-CHO trifluoroacetate salt Quick inquiry Where to buy Suppliers range | Ac-LEVD-CHO is a caspase-4 inhibitor. It inhibits IL-1α expression and secretion and caspase-4 activation induced by the T. denticola periodontal pathogen surface protein Td92 in human gingival fibroblasts when used at a concentration of 30 μM. Synonyms: Ac-Leu-Glu-Val-Asp-CHO; Caspase-4 Inhibitor I. Grades: ≥95%. CAS No. 402832-01-3. Molecular formula: C22H36N4O9·xCF3COOH. Mole weight: 500.5. | |
Ac-Val-Asp-Val-Ala-Asp-aldehyde (pseudo acid) Quick inquiry Where to buy Suppliers range | Ac-VDVAD-CHO is an inhibitor of caspase-2, -3, and -7 (Kis = 3.5, 1, and 7.5 nM, respectively). Synonyms: Ac-VDVAD-CHO; N-acetyl-L-valyl-L-alpha-aspartyl-L-valyl-L-alanyl-L-aspart-1-al; N-Acetyl-L-valyl-L-α-aspartyl-L-valyl-N-[(2S)-1-carboxy-3-oxo-2-propanyl]-L-alaninamide; L-Alaninamide, N-acetyl-L-valyl-L-α-aspartyl-L-valyl-N-[(1S)-2-carboxy-1-formylethyl]-; Caspase-2 Inhibitor (Aldehyde). Grades: ≥95%. CAS No. 194022-51-0. Molecular formula: C23H37N5O10. Mole weight: 543.57. | |
Ac-Val-Glu-Ile-Asp-aldehyde (pseudo acid) Quick inquiry Where to buy Suppliers range | Ac-VEID-CHO is an inhibitor of caspase-6 (IC50 = 16.2 nM). It is selective for caspase-6 over caspase-7 (IC50 = 162.1 nM) but can also inhibit caspase-3 (IC50 = 13.6 nM). Synonyms: N-acetyl-L-valyl-L-alpha-glutamyl-L-isoleucyl-L-aspart-1-al; N-acetyl-Val-Glu-Ile-Asp-aldehyde; N-Acetyl-L-valyl-L-alpha-glutamyl-N-[(2S)-1-carboxy-3-oxo-2-propanyl]-L-isoleucinamide; L-Isoleucinamide, N-acetyl-L-valyl-L-α-glutamyl-N-[(1S)-2-carboxy-1-formylethyl]-; N-Acetyl-Val-Glu-Ile-Asp-al; (4S,7S,10S,13S)-10-((S)-sec-butyl)-7-(2-carboxyethyl)-13-formyl-4-isopropyl-2,5,8,11-tetraoxo-3,6,9,12-tetraazapentadecan-15-oic acid; Caspase-6 Inhibitor; Ac-VEID-CHO. Grades: ≥95%. CAS No. 319494-39-8. Molecular formula: C22H36N4O9. Mole weight: 500.54. | |
Ac-WEHD-AFC Quick inquiry Where to buy Suppliers range | Ac-WEHD-AFC is a fluorogenic substrate that can be cleaved by group I caspases (caspase-1, -4, and -5).1 Caspase activity can be quantified by fluorescent detection of free AFC (also known as 7-amino-4-trifluoro methyl coumarin) , which is excited at 400 nm and emits at 505 nm. Uses: Peptide Inhibitors. CAS No. 210344-99-3. Product ID: R1870. | |
Ac-YVAD-CHO Quick inquiry Where to buy Suppliers range | Ac-YVAD-CHO is a selective inhibitor of interleukin-1β converting enzyme (ICE; Caspase-1). Uses: Cysteine proteinase inhibitors. Synonyms: Acetyl-tyrosyl-valyl-alanyl-aspartal; Ac-Tyr-Val-Ala-Asp-H; N-acetyl-Tyr-Val-Ala-Asp-aldehyde; (S)-N-Acetyl-L-tyrosyl-L-valyl-N-(2-carboxy-1-formylethyl)-L-alaninamide. Grades: ≥98%. CAS No. 143313-51-3. Molecular formula: C23H32N4O8. Mole weight: 492.52. | |
Ac-YVAD-CMK Quick inquiry Where to buy Suppliers range | Ac-YVAD-CMK is a selective, irreversible inhibitor of interleukin-1β converting enzyme (ICE; Caspase-1). Ac-YVAD-CMK is neuroprotective in a rat model of cerebral ischemia. Uses: Cysteine proteinase inhibitors. Synonyms: Caspase 1 Inhibitor II. Grades: ≥98%. CAS No. 178603-78-6. Molecular formula: C24H33ClN4O8. Mole weight: 541. | |
Alsterpaullone Quick inquiry Where to buy Suppliers range | Alsterpaullone is a potent glycogen synthase kinase-3 inhibitor and a potential therapeutic agent for the treatment of Parkinson disease. Alsterpaullone is also known as 9-Nitropaullone and NSC 705701, which is a derivative of kenpaullone and an ATP-competitive inhibitor of several cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3β (GSK3β). Alsterpaullone induces apoptosis by activation of caspase-9 due to perturbation in mitochondrial membrane potential. Alsterpaullone is a derivative of kenpaullone with slightly improved potency over kenpaullone, alsterpaullone selectively inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p25, and GSK3α/β with IC50 values of 35, 15, 200, 40, and 4 nM, respectively. Synonyms: 9-Nitropaullone; NSC 705701; 7,12-Dihydro-9-nitro-indolo[3,2-d][1]benzazepin-6(5H)-one. Grades: ≥98%. CAS No. 237430-03-4. Molecular formula: C16H11N3O3. Mole weight: 293.3. | |
APcK110 Quick inquiry Where to buy Suppliers range | KIT inhibitor; inhibits phosphorylation of KIT, STAT3, STAT5 and Akt. Suppresses proliferation of OCI/AML3 cells (IC50 = 175 nM). Caspase-dependant apoptosis inducer. Synonyms: APcK 110; APcK-110; 6-(3,5-Dimethoxyphenyl)-3-(4-fluorophenyl)-1H-pyrazolo[3,4-b]pyridine. Grades: >98%. CAS No. 1001083-74-4. Molecular formula: C34H49N5O6. Mole weight: 349.36. | |
AT7519 trifluoroacetate Quick inquiry Where to buy Suppliers range | AT7519 is an ATP competitive CDK inhibitor with a Ki value of 38 nM for CDK1. AT7519 is inactive against all non-CDK kinases with the exception of GSK3β (IC50 = 89 nM). AT7519 shows potent antiproliferative activity in a variety of human tumor cell lines with IC50 values ranging from 40 nM for MCF-7 to 940 nM for SW620 consistent with the inhibition of CDK1 and CDK2. AT7519 induces dose-dependent cytotoxicity in multiple myeloma (MM) cell lines with IC50 values ranging from 0.5 to 2 μM at 48 hours, with the most sensitive cell lines being MM.1S (0.5 μM) and U266 (0.5 μM) and the most resistant MM.1R (>2 μM). It does not induce cytotoxicity in peripheral blood mononuclear cells (PBMNC). AT7519 partially overcomes the proliferative advantage conferred by IL6 and IGF-1 as well as the protective effect of bone marrow stromal cells (BMSCs). AT7519 induces rapid dephosphorylation of RNA pol II CTD at serine 2 and serine 5 sites, and leads to the inhibition of transcription, partially contributing to AT7519 induced cytotoxicity of MM cells. AT7519 induces activation of GSK-3β by down-regulating GSK-3β phosphorylation, which also contributes to AT7519 induced apoptosis independent of the inhibition of transcription. A twice daily dosing of AT7519 (9.1 mg/kg) causes tumor regression of both early-stage and advanced-stage s.c. tumors in the HCT116 and HT29 colon cancer xenograft models. AT7519 treatment (15 mg/kg) inhibits tumor growth and prolongs the median overall survival of mice in the human MM xenograft mouse model in association with increased caspase 3 activation. Synonyms: AT 7519 trifluoroacetate; AT-7519 trifluoroacetate. Grades: >98%. CAS No. 1431697-85-6. Molecular formula: C18H18Cl2F3N5O4. Mole weight: 496.27. | |
AZ 10417808 Quick inquiry Where to buy Suppliers range | AZ 10417808 is a non-peptide and selective inhibitor of human caspase-3 with Ki value of 247 nM. It is selective over other caspases. It blocks cellular and biochemical features of apoptosis in cells. It also blocks staurosporine-induced intracellular DEVDase activity in SH-SY5Y cells. It is a bioactive chemical. Synonyms: AZ10417808; AZ-10417808; AZ 10417808; 2-[(3,4-Dichlorophenyl)amino]-1,4-dihydro-6-nitro-4-oxo-N-2-propenyl-8-quinazolinecarboxamide; AQZ-1. Grades: ≥98% by HPLC. CAS No. 331645-84-2. Molecular formula: C18H13Cl2N5O4. Mole weight: 434.23. | |
AZD 5582 dihydrochloride Quick inquiry Where to buy Suppliers range | AZD 5582 dihydrochloride is a potent inhibitor of X-linked (XIAP) and cellular (cIAP) inhibitor of apoptosis protein. It can bind to the BIR3 domain of XIAP to prevent interaction with caspase-9. Synonyms: 3,3'-[2,4-Hexadiyne-1,6-diylbis[oxy[(1S,2R)-2,3-dihydro-1H-indene-2,1-diyl]]]bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolinamide. Grades: ≥97%. CAS No. 1883545-51-4. Molecular formula: C58H78N8O8·2HCl. Mole weight: 1088.21. | |
AZD5991 Quick inquiry Where to buy Suppliers range | AZD5991 is a potent and selective Mcl-1 inhibitor with an IC50 of <3 nM in FRET assay for treatment of hematologic cancers. AZD5991 has high selectivity and affinity for Mcl-1 and is currently in clinical development. AZD5991 shows potent antitumor activity in vivo with complete tumor regression in several models of multiple myeloma and acute myeloid leukemia after a single tolerated dose as monotherapy or in combination with bortezomib or venetoclax. AZD5991 monotherapy caused apoptosis preferentially in hematological cell lines with 6/22 AML and 7/19 MM cell lines showing caspase EC50 values <100 nM. In solid tumor cell lines single agent activity was seen mostly in NSCLC and BrCa. Uses: Antineoplastic agents. Synonyms: AZD-5991; AZD 5991; AZD-5991 Racemate; 22H-9, 4, 8-(Metheniminomethyno)-14, 20:26, 23-dimetheno-10H, 20H-pyrazolo[4, 3-l][2, 15, 22, 18, 19]benzoxadithiadiazacyclohexacosine-32-carboxylic acid, 5-chloro-2,11,12,24,27,29-hexahydro-2,3,24,33-tetramethyl-. Grades: ≥98%. CAS No. 2143010-83-5. Molecular formula: C35H34ClN5O3S2. Mole weight: 672.26. | |
BCH Quick inquiry Where to buy Suppliers range | BCH is an inhibitor of L-type amino acid transporter (LAT1), which is a therapeutic target for human esophageal squamous cell carcinoma. BCH inhibits growth and induces apoptosis via activation of caspases in KB, Saos2 and C6 cancer cell lines. Synonyms: 2-Aminobicyclo[2.2.1]heptane-2-carboxylic acid. CAS No. 20448-79-7. Molecular formula: C8H13NO2. Mole weight: 155.2. |