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| Product | Description | |
|---|---|---|
| cathepsin B | An intracellular (lysosomal) enzyme in peptidase family C1 (papain family). Group: Enzymes. Synonyms: cathepsin B1 (obsolete); cathepsin II. Enzyme Commission Number: EC 3.4.22.1. CAS No. 9047-22-7. Cathepsin B. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4192; cathepsin B; EC 3.4.22.1; 9047-22-7; cathepsin B1 (obsolete); cathepsin II. Cat No: EXWM-4192. |  |
| Cathepsin B, Bovine spleen | Cathepsin B, Bovine spleen is a cysteine protease and is involved in multiple kinds of programmed cell death (including apoptosis, pyroptosis, ferroptosis, necroptosis, and autophagic cell death) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 9047-22-7. Pack Sizes: 100 μg. Product ID: HY-P2780. |  |
| Cathepsin B from Human, recombinant | Cathepsin B is a lysosomal cysteine protease. It is implicated in playing a role in protein degradation, arthritis, apoptosis, and cancer. Group: Enzymes. Synonyms: CTSB; 9047-22-7; APPS; CPSB; cathepsin B1 (obsolete); cathepsin II. Enzyme Commission Number: EC 3.4.22.1. CAS No. 9047-22-7. Purity: > 90% by SDS-PAGE. Cathepsin B. Mole weight: 27.8 kDa (80-333 aa). Activity: >7500 mU/mg. Storage: Stable for at least 1 year as supplied. Dilute in de-ionized water to 0.1 mg/ml and store at -80°C. Avoid repeated freezing and thawing cycles. Form: Liquid. Source: E. coli. Species: Human. CTSB; cathepsin B; 9047-22-7; APPS; CPSB; cathepsin B1 (obsolete); cathepsin II; EC 3.4.22.1. Cat No: NATE-1706. | |
| Cathepsin b inhibitor | Heterocyclic Organic Compound. Alternative Names: NEGATIVE CONTROL INHIBITOR FOR ICE PROTEASES;Z-FA-FLUOROMETHYLKETONE;Z-FA-FMK;Z-PHE-ALA-CH2F;Z-PHE-ALA-FLUOROMETHYLKETONE;Z-PHE-ALA-FMK;CASPASE INHIBITOR, NEGATIVE CONTROL;CATHEPSIN B, INHIBITOR. CAS No. 105637-38-5. Molecular formula: C21H23FN2O4. Mole weight: 386.42. Appearance: powder, white to off-white. Purity: 0.96. IUPACName: benzyl N-[1-[(4-fluoro-3-oxobutan-2-yl)amino]-1-oxo-3-phenylpropan-2-yl]carbamate. Catalog: ACM105637385. |  |
| cathepsin D | Occurs intracellularly, in lysosomes. A zymogen form is known. In peptidase family A1 (pepsin A family). Group: Enzymes. Enzyme Commission Number: EC 3.4.23.5. CAS No. 9025-26-7. CTSD. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4287; cathepsin D; EC 3.4.23.5; 9025-26-7. Cat No: EXWM-4287. | |
| Cathepsin D from Human, recombinant | Cathepsin D is a lysosomal aspartyl protease composed of a protein dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is an estrogen-regulated protein associated with tissue breakdown. Levels of cathepsin D have been positively correlated with recurring breast cancers of both node negative and node positive types. Additionally cathepsin D has been associated with amyloid formation in Alzheimer's plaques. Cathepsin D is produced initially as a pre-pro-enzyme which gets transported to lysosomes via endosomes in most cell types. In endosomes, it gets proteolyzed by unidentified proteases by removal of the pro-peptide to generate...e cathepsins B and L generates mature, active double-chain Cathepsin D. Group: Enzymes. Synonyms: CTSD; 9025-26-7; EC 3.4.23.5; CLN10; CPSD; HEL-S-130P; Procathepsin D. Enzyme Commission Number: EC 3.4.23.5. CAS No. 9025-26-7. Purity: > 80% by SDS-PAGE. CTSD. Mole weight: 45.1 kDa. Activity: >100 pmol/min/mg. Storage: Store at -20°C. Stable for at least 6 months as supplied. Reconstitute to 1 mg/ml in sterile water, store at -80°C in aliquots and use within 6 months after reconstitution. Avoid repeated freeze-thaw cycles. Form: Freeze-Dried. Source: E. coli. Species: Human. CTSD; cathepsin D; 9025-26-7; EC 3.4.23.5; CLN10; CPSD; HEL-S-130P; Procathepsin D. Cat No: NATE-1707. | |
| cathepsin E | Found in stomach, spleen, erythrocyte membrane; not lysosomal. Pro-cathepsin E is an 86 kDa disulfide-linked dimer; activation or reduction produces monomer. In peptidase family A1 (pepsin A family). Group: Enzymes. Synonyms: slow-moving proteinase; erythrocyte membrane aspartic proteinase; SMP; erythrocyte membrane aspartic proteinase; EMAP; non-pepsin proteinase; cathepsin D-like acid proteinase; cathepsin E-like acid proteinase; cathepsin D-type proteinase. Enzyme Commission Number: EC 3.4.23.34. CAS No. 110910-42-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4271; cathepsin E; EC 3.4.23.34; 110910-42-4; slow-moving proteinase; erythrocyte membrane aspartic proteinase; SMP; erythrocyte membrane aspartic proteinase; EMAP; non-pepsin proteinase; cathepsin D-like acid proteinase; cathepsin E-like acid proteinase; cathepsin D-type proteinase. Cat No: EXWM-4271. | |
| cathepsin F | Cathepsin F is a lysosomal cysteine endopeptidase of family C1 (papain family), most active at pH 5.9. The enzyme is unstable at neutral pH values and is inhibited by compound E-64. Cathepsin F is expressed in most tissues of human, mouse and rat. Human gene locus: 11q13.1-13.3. Group: Enzymes. Enzyme Commission Number: EC 3.4.22.41. CAS No. 65997-74-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4216; cathepsin F; EC 3.4.22.41; 65997-74-2. Cat No: EXWM-4216. | |
| Cathepsin F from Human, Recombinant | Cathepsin F, also known as CTSF, belongs to the cathepsin family. Cathepsins are papain familycysteine proteinases that represent a major component of the lysosomal proteolytic system. The CTSF gene isubiquitously expressed, and it maps to chromosome 11q13, close to the gene encoding cathepsin W. CTSF isthought to play a role in normal protein catabolism, and because it is highly expressed in some cancer cell lines, itmay be involved in degradative processes occurring during tumor progression. Recombinant human CTSF protein,fused to His-tag at N-terminus, was expressed in E.coli. Group: Enzymes. Enzyme Commission Number: EC 3.4.22.41. Mole weight: This protein is fused with a 6× His tag at N-terminus and has a calculated MW of 26 kDa. Form: Liquid. Source: E. coli. Species: Human. Cat No: NATE-1666. | |
| cathepsin G | From azurophil granules of polymorphonuclear leukocytes. In peptidase family S1 (trypsin family). Group: Enzymes. Synonyms: chymotrypsin-like proteinase; neutral proteinase. Enzyme Commission Number: EC 3.4.21.20. CAS No. 56645-49-9. CTSG. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4120; cathepsin G; EC 3.4.21.20; 56645-49-9; chymotrypsin-like proteinase; neutral proteinase. Cat No: EXWM-4120. | |
| CATHEPSIN G FROM HUMAN LEUKOCYTES | Heterocyclic Organic Compound. Alternative Names: CATHEPSIN G FROM HUMAN LEUKOCYTES;CATHEPSIN G, FROM HUMAN SPUTUM. CAS No. 107200-92-0. Catalog: ACM107200920. | |
| Cathepsin G, human neutrophils | Cathepsin G, human neutrophils (CTSH; ACC4) a serine protease found in polymorphonuclear neutrophils (PMNs), functions in inflammation [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CTSH; ACC4; ACC5. CAS No. 56645-49-9. Pack Sizes: 100 μg. Product ID: HY-E70227. | |
| Cathepsin G inhibitor I | Cathepsin G inhibitor I. Uses: For analytical and research use. Group: Impurity standards. CAS No. 429676-93-7. Molecular Formula: C36H33N2O6P. Mole Weight: 620.64. Catalog: APB429676937. |  |
| Cathepsin G Inhibitor I | Cathepsin G inhibitor I is a potent and selective inhibitor of cathepsin G with IC50 of 53 nM. It weakly inhibits chymotrypsin and poorly inhibits thrombin, factor Xa, factor IXa, plasmin, trypsin, tryptase, proteinase 3, and human leukocyte elastase. Synonyms: Cathepsin G Inhibitor I; 429676-93-7; Cathepsin G Inhibitor; CHEMBL164694; [2-[3-[(1-benzoylpiperidin-4-yl)-methylcarbamoyl]naphthalen-2-yl]-1-naphthalen-1-yl-2-oxoethyl]phosphonic acid; SCHEMBL1613660; DTXSID80431393; BDBM50139754; HY-103351; CS-0027703; A918760; (2-{3-[(1-Benzoyl-piperidin-4-yl)-methyl-carbamoyl]-naphthalen-2-yl}-1-naphthalen-1-yl-2-oxo-ethyl)-phosphonic acid; [2-[3-[(1-benzoylpiperidin-4-yl)-methylcarbamoyl]naphthalen-2-yl]-1-naphthalen-1-yl-2 oxoethyl]phosphonic acid. Grades: ≥95%. CAS No. 429676-93-7. Molecular formula: C36H33N2O6P. Mole weight: 620.6. |  |
| cathepsin H | Present in lysosomes of mammalian cells. In peptidase family C1 (papain family). Group: Enzymes. Synonyms: cathepsin B3; benzoylarginine-naphthylamide (BANA) hydrolase (obsolete); cathepsin Ba, aleurain; N-benzoylarginine-β-naphthylamide hydrolase. Enzyme Commission Number: EC 3.4.22.16. CAS No. 60748-73-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4196; cathepsin H; EC 3.4.22.16; 60748-73-4; cathepsin B3; benzoylarginine-naphthylamide (BANA) hydrolase (obsolete); cathepsin Ba, aleurain; N-benzoylarginine-β-naphthylamide hydrolase. Cat No: EXWM-4196. | |
| Cathepsin Inhibitor 1 | Cathepsin Inhibitor 1 is a pan-inhibitor of Cathepsin (L, L2, S, K, B). Group: Inhibitors. Alternative Names: Cathepsin Inhibitor 1; Cathepsin-Inhibitor-1; CTS-IN-1; CTS IN 1. CAS No. 225120-65-0. Molecular formula: C20H24ClN5O2. Mole weight: 401.89. Appearance: Solid powder. Purity: >98%. IUPACName: (S)-3-(tert-butyl)-N-(3-(3-chlorophenyl)-1-((cyanomethyl)amino)-1-oxopropan-2-yl)-1-methyl-1H-pyrazole-5-carboxamide. Canonical SMILES: ClC1=CC=CC (C[C@@H] (C (NCC#N)=O)NC (C2=CC (C (C) (C)C)=NN2C)=O)=C1. Catalog: ACM225120650. | |
| Cathepsin Inhibitor 1 | Osteoarthritis is currently recognized as a chronic degenerative disease, which is caused by the loss of articular cartilage and damage to underlying bone, resulting in joint instability and pain. Cathepsin Inhibitor 1 is an inhibitor of Cathepsin. The IC50s for Cathepsin L, L2, S, K, B are 7.9, 6.7, 6.0, 5.5 and 5.2 nM, respectively. Synonyms: Cathepsin-Inhibitor-1; CTS-IN-1; CTS IN 1. Grades: ≥98%. CAS No. 225120-65-0. Molecular formula: C20H24ClN5O2. Mole weight: 401.89. | |
| cathepsin K | Prominently expressed in mammalian osteoclasts, and believed to play a role in bone resorption. In peptidase family C1 (papain family). Group: Enzymes. Synonyms: cathepsin O and cathepsin X (both misleading, having been used for other enzymes); cathepsin O2. Enzyme Commission Number: EC 3.4.22.38. CAS No. 94716-09-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4213; cathepsin K; EC 3.4.22.38; 94716-09-3; cathepsin O and cathepsin X (both misleading, having been used for other enzymes); cathepsin O2. Cat No: EXWM-4213. | |
| Cathepsin K from Human, recombinant | Cathepsin K, a member of the papain cysteine proteinase family is the predominant proteinase responsible for the resorption of the bone matrix. Cathepsin cleaves proteins such as collagen type I, collagen type II and osteonectin, thereby playing a role in bone remodeling and resorption in osteoporosis, osteolytic bone metastasis and rheumatoid arthritis. Group: Enzymes. Synonyms: CTSK; CTSO; CTSO3; Cathepsin O; Cathepsin O2; Cathepsin X; EC 3.4.22.38. Enzyme Commission Number: EC 3.4.22.38. CAS No. 94716-09-3. Purity: > 95% by SDS-PAGE. Activity: >900 mU/mg protein. Storage: at -80°C. Avoid freeze/thaw. Form: Liquid. Source: E. coli. Species: Human. CTSK; CTSO; CTSO3; Cathepsin O; Cathepsin O2; Cathepsin X; EC 3.4.22.38. Cat No: NATE-1705. | |
| Cathepsin K from Mouse, recombinant | Cathepsin K, a member of the papain cysteine proteinase family is the predominant proteinase responsible for the resorption of the bone matrix. Cathepsin cleaves proteins such as collagen type I, collagen type II and osteonectin, thereby playing a role in bone remodeling and resorption in osteoporosis, osteolytic bone metastasis and rheumatoid arthritis. Group: Enzymes. Synonyms: CTSK; CTSO; CTSO3; Cathepsin O; Cathepsin O2; Cathepsin X; EC 3.4.22.38. Enzyme Commission Number: EC 3.4.22.38. CAS No. 94716-09-3. Purity: > 90% by SDS-PAGE. Mole weight: 23.4 kDa (115-329 aa). Activity: >1000 mU/mg. Storage: Stable for 6 months at -80°C. Use as provided or dilute to 0.1 mg/ml with 50% glycerol. Aliquot and store at -80°C. Avoid repeated freezing and thawing cycles, as this may lead to the loss in its activity over time. Form: Liquid. Source: E. coli. Species: Mouse. CTSK; CTSO; CTSO3; Cathepsin O; Cathepsin O2; Cathepsin X; EC 3.4.22.38. Cat No: NATE-1704. | |
| Cathepsin K from Rat, recombinant | Cathepsin K, a member of the papain cysteine proteinase family is the predominant proteinase responsible for the resorption of the bone matrix. Cathepsin cleaves proteins such as collagen type I, collagen type II and osteonectin, thereby playing a role in bone remodeling and resorption in osteoporosis, osteolytic bone metastasis and rheumatoid arthritis. Group: Enzymes. Synonyms: CTSK; CTSO; CTSO3; Cathepsin O; Cathepsin O2; Cathepsin X; EC 3.4.22.38. Enzyme Commission Number: EC 3.4.22.38. CAS No. 94716-09-3. Purity: > 90% by SDS-PAGE. Mole weight: 23.5 kDa (115-329 aa). Activity: >500 mU/mg. Storage: Stable for 6 months at -80°C. Use as provided or dilute to 0.1 mg/ml with 50% glycerol. Aliquot and store at -80°C. Avoid repeated freezing and thawing cycles, as this may lead to the loss in its activity over time. Form: Liquid. Source: E. coli. Species: Rat. CTSK; CTSO; CTSO3; Cathepsin O; Cathepsin O2; Cathepsin X; EC 3.4.22.38. Cat No: NATE-1703. | |
| cathepsin L | A lysosomal enzyme in peptidase family C1 (papain family) that is readily inhibited by the diazomethane inhibitor Z-Phe-Phe-CHN2 or the epoxide inhibitor E-64. Group: Enzymes. Synonyms: Aldrichina grahami cysteine proteinase. Enzyme Commission Number: EC 3.4.22.15. CAS No. 60616-82-2. CTSL. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4195; cathepsin L; EC 3.4.22.15; 60616-82-2; Aldrichina grahami cysteine proteinase. Cat No: EXWM-4195. | |
| Cathepsin L | Cathepsin L is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Group: Signaling pathways. CAS No. 60616-82-2. Pack Sizes: 25 μg. Product ID: HY-P2923. | |
| Cathepsin L from Human, Recombinant | Cathepsin L (EC 3.4.22.15, Aldrichina grahami cysteine proteinase) is an important lysosomal endopeptidase enzyme which is involved in the initiation of protein degradation. It is a member of the Peptidase C1 family, which play an important role in diverse processes including normal lysosome mediated protein turnover, antigen and proprotein processing, and apoptosis. Cathepsin L has been reported in many organisms including fish, birds and mammals. Group: Enzymes. Synonyms: Cathepsin L1; Major excreted protein; Cathepsin U; Cathepsin V. Enzyme Commission Number: EC 3.4.22.15. Purity: > 90% by SDS-PAGE. CTSL. Mole weight: 24.2 kDa (114-333 aa). Activity: > 10000 mU/mg. Stability: Stable for at least 6 months as supplied. Use as provided or dilute with 50% glycerol to 0.1 mg/ml. Aliquot immediately and store at -80°C. Avoid freeze/thaw cycles. Storage: Store at -80°C. Form: Liquid. Source: E. coli. Species: Human. cathepsin L; CTSL; EC 3.4.22.15; Aldrichina grahami cysteine proteinase; 60616-82-2; Cathepsin L1; Major excreted protein; Cathepsin U; Cathepsin V. Cat No: NATE-1665. | |
| Cathepsin L Inhibitor | Cathepsin L inhibitor is a potent inhibitor of cathepsin L with IC50 of 0.85 nM. It is trypanocidal with an ED50 value of 45 nM against T. brucei that is well below the ED50 value of 21,500 nM for human HL-60 cells. In vivo, cathepsin L inhibitor (2.5-10 mg/kg) inhibits bone loss in a mouse model of osteoporosis in a dose-dependent manner. Cathepsin L inhibitor can also completely suppress osteoclastic pit formation on femur slices isolated from bovine cortical bone. Synonyms: Z-FY-CHO; Z-Phe-Tyr-aldehyde; SB 412515; N-(benzyloxycarbonyl)-phenylalanyl-l-tyrosinal. Grades: ≥95%. CAS No. 167498-29-5. Molecular formula: C26H26N2O5. Mole weight: 446.49. | |
| cathepsin O | Cathepsin O is a lysosomal cysteine peptidase of family C1 (papain family). The recombinant human enzyme is catalytically active at pH 6.0 and is inhibited by compound E-64. Cathepsin O is ubiquitously expressed in human tissues and the human gene locus is 4q31-32. Group: Enzymes. Enzyme Commission Number: EC 3.4.22.42. CAS No. 162032-86-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4217; cathepsin O; EC 3.4.22.42; 162032-86-2. Cat No: EXWM-4217. | |
| cathepsin S | A lysosomal cysteine endopeptidase that is unusual amongst such enzymes for its stability to neutral pH. In peptidase family C1 (papain family). Group: Enzymes. Enzyme Commission Number: EC 3.4.22.27. CAS No. 71965-46-3. CTSS. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4201; cathepsin S; EC 3.4.22.27; 71965-46-3. Cat No: EXWM-4201. | |
| Cathepsin S from Human, recombinant | Cathepsin S (CTSS) is a lysosomal cysteine protease of the papain family and may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. CTSS is synthesized as inactive precursor of 331 amino acids consisting of a 15-aa signal peptide, a propeptide of 99 aa, and a mature polypeptide of 217 aa. It is activated in the lysosomes by a proteolytic cleavage of the propeptide. The deduced amino acid sequence contains only one potential N-glycosylation site located in the propeptide. Compared with the abundant cathepsins B, L and H, cathepsin S shows a restricted tissue distribution, with highest levels in spleen, heart, and lung...l compartment, and is implicated in the pathogenesis of Alzheimers disease and Down Syndrome. Group: Enzymes. Synonyms: CTSS; cathepsin S; EC 3.4.22.27; FLJ50259; MGC3886. Enzyme Commission Number: EC 3.4.22.27. CAS No. 71965-46-3. Purity: > 90% by SDS-PAGE. CTSS. Mole weight: 23.9 kDa (115-331 aa). Activity: >2000 mU/mg. Storage: Stable for at least 1 year as supplied. Briefly spin down the vial and reconstitute in 50 mM sodium acetate, 100 mM NaCl (pH 5.5) to 0.1-1 mg/ml and store at -80°C. Avoid repeated freeze and thaw cycles. Form: Lyophilized from proprietary buffer. Source: E. coli. Species: Human. CTSS; cathepsin S; EC 3.4.22.27; FLJ50259; MGC3886. Cat No: NATE-1702. | |
| Cathepsin S, human | Cathepsin S, human, is a potent cysteine protease that promotes the degradation of damaged or harmful proteins in the endolysosomal pathway. Cathepsin S, human, is involved in multiple pathological processes, including arthritis, cancer, and cardiovascular disease [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CTSS. CAS No. 71965-46-3. Pack Sizes: 50 μg. Product ID: HY-E70226. | |
| Cathepsin S inhibitor | Cathepsin S is expressed in antigen-presenting cells and plays a role in invariant chain processing and major histocompatibility complex class II (MHCII) antigen presentation leading to CD4+ T-cell activation. An oral Cathepsin S inhibitor that blocks MHCII antigen presentation could result in a T-cell-selective immunosuppressant agent with improved safety over the current standard of care for the treatment of rheumatoid arthritis, psoriasis, multiple sclerosis and other autoimmune-based inflammatory diseases. Synonyms: LY3000328; LY-3000328; LY 3000328. Cathepsin S inhibitor. Grades: >98%. CAS No. 1373215-15-6. Molecular formula: C25H29FN4O5. Mole weight: 484.52. | |
| cathepsin T | Degrades azocasein and denatured hemoglobin; the only native protein on which it has been shown to act is tyrosine aminotransferase. Group: Enzymes. Enzyme Commission Number: EC 3.4.22.24. CAS No. 77464-86-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4198; cathepsin T; EC 3.4.22.24; 77464-86-9. Cat No: EXWM-4198. | |
| cathepsin V | Cathepsin V is a human lysosomal cysteine endopeptidase of family C1 (papain family) that is maximally active at pH 5.7 and unstable at neutral pH. Compound E-64, leupeptin and chicken cystatin are inhibitors. Human cathepsin V shows expression restricted to thymus, testis, corneal epithelium and some colon and breast carcinomas. Human gene locus: 9q22.2. Group: Enzymes. Synonyms: Cathepsin L2; cathepsin U. Enzyme Commission Number: EC 3.4.22.43. CAS No. 223670-00-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4218; cathepsin V; EC 3.4.22.43; 223670-00-6; Cathepsin L2; cathepsin U. Cat No: EXWM-4218. | |
| cathepsin X | Cathepsin X is a lysosomal cysteine peptidase of family C1 (papain family). The pH optimum is dependent on the substrate and is 5.0 for the carboxypeptidase activity. Unstable above pH 7.0. Compound E-64, leupeptin and antipain are inhibitors, but not cystatin C. Cathepsin X is ubiquitously distributed in mammalian tissues. The propeptide is extremely short (38 amino acid residues) and the proenzyme is catalytically active. Human gene locus: 20q13. Group: Enzymes. Synonyms: cathepsin B2; cysteine-type carboxypeptidase; cathepsin IV; cathepsin Z; acid carboxypeptidase; lysosomal carboxypeptidase B. Enzyme Commission Number: EC 3.4.18.1. CAS No. 37217-21-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4081; cathepsin X; EC 3.4.18.1; 37217-21-3; cathepsin B2; cysteine-type carboxypeptidase; cathepsin IV; cathepsin Z; acid carboxypeptidase; lysosomal carboxypeptidase B. Cat No: EXWM-4081. | |
| Native Bovine Cathepsin B | Cathepsin B has been found to cleave procaspase 1 and procaspase 11 and to induce apoptosis in digitonin-permeabilized cells. Translocation of cathepsin B from the cytoplasm to the nucleus contributes to bile salt induced apoptosis of Rat hepatocytes. Levels of cathepsin B in PC12 cells significantly decrease 12 to 24 hours after apoptosis is induced. Group: Enzymes. Synonyms: CTSB; cathepsin B; 9047-22-7; APPS; CPSB; cathepsin B1 (obsolete); cathepsin II. CAS No. 9047-22-7. Cathepsin B. Activity: > 10 units/mg protein. Form: Lyophilized powder containing sodium phosphate, sodium chloride and ~6% EDTA as stabilizer. Source: Bovine spleen. Species: Bovine. CTSB; cathepsin B; 9047-22-7; APPS; CPSB; cathepsin B1 (obsolete); cathepsin II. Cat No: NATE-0167. | |
| Native Bovine Cathepsin C | Cathespin C is a dipeptidyl aminopeptidase that can sequentially remove dipeptides from a peptide chain with an unsubstituted N-terminus. The enzyme exhibits a preference for glycine and proline as N-terminal aminoacids. Substrates that have an N-terminal lysyl or arginyl residue, or a penultimate proryl residue are not targeted by this enzyme. The endopeptidase activity requires the presence of halide ions and sulfydryl activators. Applications: Cathepsin c has been used in a study that demonstrated the potential of a proteomics approach to identify novel proteins expressed by extravillous trophoblast and to uncover the mechanisms leading to disease states in pregnancy. catheps...s. Synonyms: CTSC; cathepsin C; 9032-68-2; EC 3.4.14.1; dipeptidyl aminopeptidase I; dipeptidyl transferase; dipeptidyl transferase; dipeptide arylamidase I; DAP I; dipeptidyl-peptidase I; DPP-I; CPPI; DPP1; DPPI; HMS; JP; JPD; PALS; PDON1; PLS. Enzyme Commission Number: EC 3.4.14.1. CAS No. 9032-68-2. CTSC. Activity: > 5 units/mg protein. Form: Lyophilized from a 1 M sodium chloride solution. Source: Bovine spleen. Species: Bovine. CTSC; cathepsin C; 9032-68-2; EC 3.4.14.1; dipeptidyl aminopeptidase I; dipeptidyl transferase; dipeptidyl transferase; dipeptide arylamidase I; DAP I; dipeptidyl-peptidase I; DPP-I; CPPI; DPP1; DPPI; HMS; JP; JPD; PALS; PDON1; PLS. Cat No: NATE-0170. | |
| Native Bovine Cathepsin D | Cathepsin D is an endosomal-lysosomal aspartic protease implicated in breast cancer metastasis and Alzheimers disease. Lysosomal release of cathepsin D has been found to precede cytochrome c release and loss of membrane potential in apoptotic Human foreskin fibroblasts. Cathepsin D levels in PC12 cells increase 12 to 24 hours after apoptosis is induced. Group: Enzymes. Synonyms: CTSD; cathepsin D; 9025-26-7; EC 3.4.23.5; CLN10; CPSD; HEL-S-130P. Enzyme Commission Number: EC 3.4.23.5. CAS No. 9025-26-7. CTSD. Mole weight: 45 kDa. Activity: > 2.0 units/mg protein. Form: Lyophilized powder containing Citrate buffer salts. Source: Bovine spleen. Species: Bovine. CTSD; cathepsin D; 9025-26-7; EC 3.4.23.5; CLN10; CPSD; HEL-S-130P. Cat No: NATE-0171. | |
| Native Human Cathepsin B | Cathepsin B has been found to cleave procaspase 1 and procaspase 11 and to induce apoptosis in digitonin-permeabilized cells. Translocation of cathepsin B from the cytoplasm to the nucleus contributes to bile salt induced apoptosis of rat hepatocytes. Levels of cathepsin B in PC12 cells significantly decrease 12 to 24 hours after apoptosis is induced. Group: Enzymes. Synonyms: CTSB; cathepsin B; cathepsin B1; APPS; CPSB; EC 3.4.22.1; 9047-22-7; cathepsin II; CatB. Enzyme Commission Number: EC 3.4.22.1. CAS No. 9047-22-7. Cathepsin B. Activity: > 2 ,000 units/mg protein (E1%/280). Storage: -20°C. Form: buffered aqueous solution. Solution in 50 mM sodium acetate, pH 5.0, with 1 mM EDTA. Source: Human liver. Species: Human. CTSB; cathepsin B; cathepsin B1; APPS; CPSB; EC 3.4.22.1; 9047-22-7; cathepsin II; CatB. Cat No: NATE-0168. | |
| Native Human Cathepsin D | Cathepsin D is an endosomal-lysosomal aspartic protease implicated in breast cancer metastasis and Alzheimers disease. Lysosomal release of cathepsin D has been found to precede cytochrome c release and loss of membrane potential in apoptotic human foreskin fibroblasts. Cathepsin D levels in PC12 cells increase 12 to 24 hours after apoptosis is induced. Group: Enzymes. Synonyms: CTSD; cathepsin D; CLN10; CPSD; HEL-S-130P; EC 3.4.23.5; 9025-26-7. Enzyme Commission Number: EC 3.4.23.5. CAS No. 9025-26-7. CTSD. Activity: > 250 units/mg protein (E1%/280). Storage: -20°C. Form: lyophilized powder. Source: Human liver. Species: Human. CTSD; cathepsin D; CLN10; CPSD; HEL-S-130P; EC 3.4.23.5; 9025-26-7. Cat No: NATE-0172. | |
| Native Human Cathepsin G | Cathepsin G is an enzymatic protein belonging to the peptidase or protease families. In humans, it is coded by the CTSG gene. The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. The encoded protease has a specificity similar to that of chymotrypsin C, but it is most closely related to other immune serine proteases, such as neutrophil elastase and the granzymes. Cathepsin G may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. It also localizes to Neutrophil extracellular traps (NETs), via its high affinity for DNA, an unusual property for serine proteases. Transcript variants utilizing alternative polyadenylation signals exist for this gene. Group: Enzymes. Synonyms: CTSG; cathepsin G; CG; CATG; EC 3.4.21.20; chymotrypsin-like proteinase; neutral proteinase. Enzyme Commission Number: EC 3.4.21.20. CAS No. 56645-49-9. Purity: > 96% (SDS-PAGE). CTSG. Activity: > 5 U/mL. Appearance: Clear, colorless solution. Storage: 2-8°C. Form: Liquid. Source: Human Neutrophils. Species: Human. CTSG; cathepsin G; CG; CATG; EC 3.4.21.20; chymotrypsin-like proteinase; neutral proteinase. Cat No: NATE-0173. | |
| Native Human Cathepsin H | Cathepsin H is a protein that in humans is encoded by the CTSH gene. The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. Two transcript variants encoding different isoforms have been found for this gene. Group: Enzymes. Synonyms: CTSH; cathepsin H; CPSB; ACC-4; ACC-5; ACC4; ACC5; CPSB; minichain. Purity: > 95% (SDS-PAGE). CTSH. Mole weight: 28 kDa. Storage: -40°C. Form: Liquid. Source: Human Liver. Species: Human. CTSH; cathepsin H; CPSB; ACC-4; ACC-5; ACC4; ACC5; CPSB; minichain. Cat No: NATE-0176. | |
| Native Human Cathepsin L | Cathepsin L (EC 3.4.22.15, Aldrichina grahami cysteine proteinase) is an important lysosomal endopeptidase enzyme which is involved in the initiation of protein degradation. It is a member of the Peptidase C1 family, which play an important role in diverse processes including normal lysosome mediated protein turnover, antigen and proprotein processing, and apoptosis. Cathepsin L has been reported in many organisms including fish, birds and mammals. Applications: The most powerful of the lysosomal proteinases. it has a higher specific activity than cathepsin b and h in the degradation of a variety of physiological protein substrates. Group: Enzymes. Synonyms: cathepsin L; CTSL; EC 3.4.22.15; Aldrichina grahami cysteine proteinase; 60616-82-2. Enzyme Commission Number: EC 3.4.22.15. CAS No. 60616-82-2. CTSL. Activity: > 0.5 units/mg protein. Storage: -20°C. Form: Solution in in 20 mM malonate, pH 5.5, 1 mM EDTA, and 400 mM NaCl. Source: Human liver. Species: Human. cathepsin L; CTSL; EC 3.4.22.15; Aldrichina grahami cysteine proteinase; 60616-82-2. Cat No: NATE-0177. | |
| Native Human Cathepsin S | Cathepsin S is a lysosomal cysteine protease found primarily in the spleen and in lung macrophages. Its level is elevated in the brain tissue of those with Alzheimer's disease and Down syndrome. Cathepsin S may function in the processing of amyloid precursor protein to amyloid beta peptides. Applications: Cathepsin s from human spleen has been used in a study to assess the sequence identification, tissue distribution and polymorphism of the porcine cathepsin d (ctsd) gene. cathepsin s from human spleen has also been used in a study to investigate a new promising camptothecin analogue-polysaccharide conjugate. Group: Enzymes. Synonyms: CTSS; cathepsin S; EC 3.4.22.27; FLJ50259; MGC3886. Enzyme Commission Number: EC 3.4.22.27. CTSS. Storage: -70°C. Form: lyophilized powder. Lyophilized from 100 mM sodium acetate, pH 5.5, and 1 mM EDTA. Source: Human spleen. Species: Human. CTSS; cathepsin S; EC 3.4.22.27; FLJ50259; MGC3886. Cat No: NATE-0178. | |
| Procathepsin B (26-50) (rat) | Procathepsin B (26-50) (rat) is completely resistant to proteolysis by cathepsin B even after incubation overnight. It inhibits human cathepsin B with a Ki of 2.8 μM and rat cathepsin B with a Ki of 2 μM. Synonyms: H-Ala-Gly-Arg-Asn-Phe-Tyr-Asn-Val-Asp-Ile-Ser-Tyr-Leu-Lys-Lys-Leu-Cys-Gly-Thr-Val-Leu-Gly-Gly-Pro-Lys-NH2; L-alanyl-glycyl-L-arginyl-L-asparagyl-L-phenylalanyl-L-tyrosyl-L-asparagyl-L-valyl-L-alpha-aspartyl-L-isoleucyl-L-seryl-L-tyrosyl-L-leucyl-L-lysyl-L-lysyl-L-leucyl-L-cysteinyl-glycyl-L-threonyl-L-valyl-L-leucyl-glycyl-glycyl-L-prolyl-L-lysinamide. Grades: ≥95%. CAS No. 317331-27-4. Molecular formula: C123H198N34O33S. Mole weight: 2713.16. | |
| 1,1,2-Ethanetricarboxylic Acid 1,1,2-Triethyl Ester | 1,1,2-Ethanetricarboxylic Acid 1,1,2-Triethyl Ester is a useful synthetic intermediate. It can be used to prepare Isobutylsuccinic Acid (I780660) which was used to synthesize succinimide derivatives as inhibitors of human leukocyte elastase, cathepsin G and proteinase 3. Group: Biochemicals. Grades: Highly Purified. CAS No. 7459-46-3. Pack Sizes: 5g, 10g. Molecular Formula: C11H18O6. US Biological Life Sciences. |  Worldwide |
| 1- (2-Hydroxyphenyl) -4- (tert-butoxycarbonyl) piperazine | 1- (2-Hydroxyphenyl) -4- (tert-butoxycarbonyl) piperazine is an intermediate used to synthesize 2-(1-Piperazinyl)-benzenethiol which is used to used to prepare 3,5-dioxo-(2H,4H)-1,2,4-triazine as 5-HT1AR ligands. 1- (2-Hydroxyphenyl) -4- (tert-butoxycarbonyl) piperazine is also used to prepare nonpeptidic biaryl inhibitors of human cathepsin K in relation to treatment of osteoporosis. Group: Biochemicals. Grades: Highly Purified. CAS No. 313657-51-1. Pack Sizes: 1g, 10g. Molecular Formula: C15H22N2O3, Molecular Weight: 278.35. US Biological Life Sciences. | Worldwide |
| 1, ?2-?Piperidinedicarboxyl ?ic Acid 1-?(Phenylmethyl) Ester | 1, ?2-?Piperidinedicarboxyl ?ic Acid 1-?(Phenylmethyl) Ester is used to prepare disubstituted azetidinones as selective inhibitors of cysteine protease cathepsin K. It is also used to synthesize 2-?[(R)?-?2-?methylpyrrolidin-?2-?yl]?-?1H-?benzimidazole-?4-?carboxamide (ABT-?888) as the Poly(ADP-?ribose) Polymerase (PARP) inhibitor for the treatment of cancer. Group: Biochemicals. Grades: Highly Purified. CAS No. 28697-07-6. Pack Sizes: 25g, 100g. Molecular Formula: C14H17NO4, Molecular Weight: 263.29. US Biological Life Sciences. | Worldwide |
| 1,3-Bis-(Z-Leu-Leu)-diaminoacetone | 1,3-Bis-(Z-Leu-Leu)-diaminoacetone, a cysteine protease inhibitor, can specifically and efficiently inhibit the processing of p-Prl signal peptide (IC50 ca. 50 nM) without affecting the activity of signal peptidase and lysosomal cathepsin, proteasome, and other proteases. Synonyms: (Z-LL)2 Ketone; Z-Leu-Leu-NH-CH2-CO-CH2-NH-Leu-Leu-Z; 2,2'-(2-Oxo-1,3-propanediyl)bis[N-[(phenylmethoxy)carbonyl]-L-leucyl-L-leucinamide; 1,3-di-(N-carboxybenzoyl-leucyl-leucyl)aminoacetone; Dibenzyl [(4S,7S,15S,18S)-7,15-diisobutyl-2,20-dimethyl-5,8,11,14,17-pentaoxo-6,9,13,16-tetraazahenicosane-4,18-diyl]biscarbamate. Grades: ≥95%. CAS No. 313664-40-3. Molecular formula: C43H64N6O9. Mole weight: 809.00. | |
| [1- (4-Bromophenyl) cyclopropyl]methanol | Used for preparation of amino acid derivatives as cathepsin cysteine protease inhibitors. Group: Biochemicals. Alternative Names: 1-(4-Bromophenyl)-1-cyclopropanemethanol; 1- (p-Bromophenyl) cyclopropanemethanol. Grades: Highly Purified. CAS No. 98480-31-0. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| 1-Naphthalenylsulfonyl-Ile-Trp-aldehyde | 1-Naphthalenylsulfonyl-Ile-Trp-aldehyde is a potent, reversible, selective and cell-permeable cathepsin L inhibitor with an IC50 of 1.9 nM. It inhibits the release of bone Ca2+ and hydroxyproline in vitro and is useful in the treatment of osteoporosis. Synonyms: N-(1-Naphthalenylsulfonyl)-Ile-Trp-aldehyde; Pentanamide, N-[(1S)-1-formyl-2-(1H-indol-3-yl)ethyl]-3-methyl-2-[(1-naphthalenylsulfonyl)amino]-, (2S,3S)-; N-[(2S)-1-(1H-Indol-3-yl)-3-oxo-2-propanyl]-N2-(1-naphthylsulfonyl)-L-isoleucinamide; N-(1Naphthalenylsulfonyl)-IW-CHO; Cathepsin L Inhibitor IV. Grades: ≥95%. CAS No. 161709-56-4. Molecular formula: C27H29N3O4S. Mole weight: 491.61. | |
| 1-Pyrrolidinyl-3-pyridineacetic Acid | 1-Pyrrolidinyl-3-pyridineacetic Acid is a reagent that is used in the synthesis of phenylalanine cyanomethylamides as cathepsin B inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 933760-99-7. Pack Sizes: 10mg, 100mg. Molecular Formula: C12H15NO2, Molecular Weight: 205.25. US Biological Life Sciences. | Worldwide |
| 1- (t-Butoxycarbonyl) aminocyclobutanecarboxylic acid | Boc-1-aminocyclobutane-1-carboxylic Acid is used in the synthesis of dipeptidyl nitriles with cathepsin-inhibiting activities. It is also used to prepare alkyl-oxo-aryl amides as novel antagonists of TRPA1 receptor. Synonyms: Boc-Acb(1)-OH; N-Boc-1-Aminocyclobutanecarboxylic acid; 1-(Boc-amino)cyclobutanecarboxylic Acid; 1- ( (tert-Butoxycarbonyl) amino) cyclobutanecarboxylic acid; 1-[(2-methylpropan-2-yl)oxycarbonylamino]cyclobutane-1-carboxylic acid; N-α-(t-Butoxycarbonyl)cyclovaline. Grades: ≥ 95% (Assay). CAS No. 120728-10-1. Molecular formula: C10H17NO4. Mole weight: 215.25. | |
| 1-[ (tert-Butyloxycarbonyl) amino]propane-2, 3-diol | 1-[ (tert-Butyloxycarbonyl) amino]propane-2, 3-diol is a reagent used in the synthesis of analogs of Vestipitant, potent and orally NK1 antagonists. Also, it is the used in the synthesis of N-Boc-2-aminoacetaldehyde (B600600), which is used in the synthesis of carbohydrates as well as studies relating to inhibitors of cathepsin K. Group: Biochemicals. Grades: Highly Purified. CAS No. 137618-48-5. Pack Sizes: 250mg, 1g. Molecular Formula: C8H17NO4, Molecular Weight: 191.22. US Biological Life Sciences. | Worldwide |
| 2-(1-Piperazinyl)-phenol Dihydrochloride | 2-(1-Piperazinyl)-phenol Dihydrochloride, is used to prepare nonpeptidic biaryl inhibitors of human cathepsin K in relation to treatment of osteoporosis. It is also used to synthesize serotonin transporters/histamine H3 receptors. Group: Biochemicals. Grades: Highly Purified. CAS No. 667864-86-0. Pack Sizes: 1g, 10g. Molecular Formula: C10H14N2O 2HCl. US Biological Life Sciences. | Worldwide |
| 2,3,4-Trimethyl-3-pentanol | 2,3,4-Trimethyl-3-pentanol is used to prepare cathepsin K inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 3054-92-0. Pack Sizes: 1g, 5g. Molecular Formula: C8H18O, Molecular Weight: 130.229999999999. US Biological Life Sciences. | Worldwide |
| 2,3-Dichloro-D-β-homophenylglycine | 2,3-Dichloro-D-β-homophenylglycine is used as a reactant in the preparation of (thiazolylcarbonylamino)propionic acid derivatives as cathepsin A inhibitors. Synonyms: H-D-Phg(2,3-Cl2)-(C#CH2)OH; H-D-β-Phe(2,3-Cl2)-OH; (S)-3-Amino-3-(2,3-dichlorophenyl)propanoic acid. Grades: ≥ 98% (HPLC). CAS No. 748128-13-4. Molecular formula: C9H9Cl2NO2. Mole weight: 234.08. | |
| 2,5-Difluorobenzoic acid | 2,5-Difluorobenzoic Acid acts as a reagent in the synthesis of rutaecarpine and analogs used for the removal of caffeine from the body. Prepparation of quinolone carboxylic acids as cell-permeable inhibitors of protein tyrosine phosphatase (Erratum). Preparation, molecular docking, and bioactivity of α-ketoamides as cathepsin S inhibitors with potential applications against tumor invasion and angiogenesis. Also used as new passive water tracers for oil field applications. Synonyms: NSC 190310; 5-Difluorobenzoic acid; 2,5-difluorobenzoate. Grades: ≥95%. CAS No. 2991-28-8. Molecular formula: C7H4F2O2. Mole weight: 158.10. | |
| 2-Amino-2-oxo-acetic Acid Ethyl Ester | 2-Amino-2-oxo-acetic Acid Ethyl Ester is a reagent used to prepare methanotetra hydroiso quinolinecarboxyl ic acid. It can also be used in preparation of 1,2,4-Thiadiazole, a Cathepsin B inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 617-36-7. Pack Sizes: 5g, 10g. Molecular Formula: C4H7NO3, Molecular Weight: 117.1. US Biological Life Sciences. | Worldwide |
| 2-Chloro-3- (trifluoromethyl) benzoic Acid | 2-Chloro-3- (trifluoromethyl) benzoic Acid is a reactant in the preparation of trifluoromethylphenyl as P2 for ketoamide-based cathepsin S inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 39226-97-6. Pack Sizes: 1g, 10g. Molecular Formula: C8H4ClF3O2, Molecular Weight: 224.56. US Biological Life Sciences. | Worldwide |
| 2-Chloro-N-methoxy-N-methylbenzamide | 2-Chloro-N-methoxy-N-methylbenzamide was used as a reagent in the synthesis of functionalized β-oxonitriles. Also used in the synthesis of potent thiosemicarbazone based cathepsin L inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 289686-74-4. Pack Sizes: 500mg, 1g. Molecular Formula: C9H10ClNO2, Molecular Weight: 199.63. US Biological Life Sciences. | Worldwide |
| 2-Pyrimidinecarbonitrile | Cathepsin K is a lysosomal cysteine protease found in osteoclasts whose elevated activity has been linked to the formation of osteoporosis and arthritis. 2-cyano-Pyrimidine is a cathepsin K inhibitor. Synonyms: pyrimidine-2-carbonitrile. Grades: 95+%. CAS No. 14080-23-0. Molecular formula: C5H3N3. Mole weight: 105.10. | |
| (2R,?3R)?-2-Bromo-3-hydroxybutanedioic Acid 1,4-Diethyl Ester | (2R,?3R)?-2-Bromo-3-hydroxybutanedioic Acid 1,4-Diethyl Ester is an intermediate in the synthesis of derivative of E-64 an inhibitor of cathepsins B and L as well as a potential inhibitor of calpain. Group: Biochemicals. Grades: Highly Purified. CAS No. 80640-15-9. Pack Sizes: 1g, 5g. Molecular Formula: C8H13BrO5. US Biological Life Sciences. | Worldwide |
| (2R)-4-Phenylbutan-2-amine-d3 | (2R)-4-Phenylbutan-2-amine is an isotope labelled intermediate in the synthesis of potent Cathepsin S inhibitor. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg, 25mg. Molecular Formula: C10H12D3N. US Biological Life Sciences. | Worldwide |
| (2R)-4-Phenylbutan-2-amine p-Toluenesulfonic Acid | (2R)-4-Phenylbutan-2-amine p-Toluenesulfonic Acid is an intermediate in the synthesis of potent Cathepsin S inhibitor. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 5mg. Molecular Formula: C17H23NO3S. US Biological Life Sciences. | Worldwide |
| (2S, 3S) -3- [ [ [ (1S) -1- [ [ (4-Azidobutyl) amino] carbonyl] -3-methylbutyl] amino] carbonyl] -2-oxiranecarboxylic Acid Ethyl Ester | N3Le is a derivative of E-64 an inhibitor of cathepsins B and L as well as a potential inhibitor of calpain. E-64d has been shown to inhibit lysosomal proteases. Group: Biochemicals. Grades: Highly Purified. CAS No. 1174021-95-4. Pack Sizes: 1mg, 10mg. Molecular Formula: C16H27N5O5. US Biological Life Sciences. | Worldwide |
| 3-Cyano-1,2,4-triazole | A cyano substituted triazole with inhibitory effects on cathepsin K used in a study of the electrophilicity and reactivity of diverse nitrile-containing compounds and its correlation to the mechanism-of-action. Group: Biochemicals. Alternative Names: 1H-1,2,4-Triazole-3-carbonitrile; s-Triazole-3-carbonitrile. Grades: Highly Purified. CAS No. 3641-10-9. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
| 3-epi-Ursolic Acid | 3-epi-Ursolic Acid is a potent inhibitor against glycogen phosphorylase which makes it a potential rug for treatment of type-2 diabetes and other diseases associated with glycogen metabolism. It is also a part of the group of triterpenoids that act as novel inhibitors of Human Cathepsin L. Group: Biochemicals. Grades: Highly Purified. CAS No. 989-30-0. Pack Sizes: 5mg, 10mg. Molecular Formula: C30H48O3, Molecular Weight: 456.7. US Biological Life Sciences. | Worldwide |
| 3-Iodo-N-[(benzyloxy)carbonyl]-L-tyrosine | 3-Iodo-N-[(benzyloxy)carbonyl]-L-tyrosine is a reactant used in the preparation of diazonamide A and peptidyl and azapeptidyl Me ketones as substrate analog inhibitors of papain and cathepsin B. Group: Biochemicals. Alternative Names: 3-Iodo-N-[ (phenylmethoxy) carbonyl]-L-tyrosine. Grades: Highly Purified. CAS No. 79677-62-6. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| 3-Methyl-D-phenylalanine | 3-Methyl-D-phenylalanine is a derivative of D-Phenylalanine and is used as a reagent in the synthesis of aminophenylpropanyl phosphate derivatives which can exhibit pin1 inhibitory activity. 3-Methyl-D-phenylalanine is also used in the preparation of N-arylaminonitriles which are useful as bioavailable peptidomimetic inhibitors of cathepsin B. Synonyms: D-Phe(3-Me)-OH; m-Methyl-D-phenylalanine; (R)-2-Amino-3-(3-methylphenyl)propanoic acid; (R)-2-Amino-3-(m-tolyl)propanoic acid; D-3-Methylphenylalanine; D-PHENYLALANINE, 3-METHYL-; 3-Methy-D-Phenylalanine; H-D-PHE(3-ME)-OH; (2R)-2-amino-3-(3-methylphenyl)propanoic acid; (R)-2-amino-3-m-tolylpropanoic acid. Grades: ≥ 99% (HPLC). CAS No. 114926-39-5. Molecular formula: C10H13NO2. Mole weight: 179.22. | |
| 5-Nitro-8-hydroxyquinoline | 5-Nitro-8-hydroxyquinoline is an antimicrobial agent used for the treatment of urinary tract infection. 5-Nitro-8-hydroxyquinoline is also a potent and reversible inhibitor of cathepsin B. 5-Nitro-8-hydroxyquinoline has been shown to have anti-cancer activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 4008-48-4. Pack Sizes: 10g, 25g, 100g, 250g. Molecular Formula: C?H?N?O?, Melting Point: >179ºC (dec.). US Biological Life Sciences. | Worldwide |
| Abz-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (669-674)-EDDnp | Abz-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (669-674)-EDDnp is an intramolecularly quenched fluorescent substrate with the ortho-aminobenzoyl (Abz)/N-(2,4-dinitrophenyl)ethylenediamine (EDDnp) groups as the donor/acceptor pair. It corresponds to the Swedish-mutated (JMV2236) β-amyloid precursor protein (βAPP) sequence, which is targeted by β-secretase BACE (β-site APP-cleaving activity). It is more selectively cleaved by BACE1 and BACE2 than by cathepsin D, a disintegrin and metalloprotease 10 (ADAM10), tumor necrosis α-converting enzyme (TACE), presenilin-1 (PS1), or presenilin-2 (PS2). Synonyms: JMV2236; L-α-Glutamine, N-(2-aminobenzoyl)-L-valyl-L-asparaginyl-L-leucyl-L-α-aspartyl-L-alanyl-N-[2-[(2,4-dinitrophenyl)amino]ethyl]-; N-(2-Aminobenzoyl)-L-valyl-L-asparaginyl-L-leucyl-L-α-aspartyl-L-alanyl-N-{2-[(2,4-dinitrophenyl)amino]ethyl}-L-α-glutamine. Grades: ≥95%. CAS No. 1007306-20-8. Molecular formula: C42H58N12O16. Mole weight: 986.99. | |
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