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| Product | Description | |
|---|---|---|
| cathepsin L | A lysosomal enzyme in peptidase family C1 (papain family) that is readily inhibited by the diazomethane inhibitor Z-Phe-Phe-CHN2 or the epoxide inhibitor E-64. Group: Enzymes. Synonyms: Aldrichina grahami cysteine proteinase. Enzyme Commission Number: EC 3.4.22.15. CAS No. 60616-82-2. CTSL. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4195; cathepsin L; EC 3.4.22.15; 60616-82-2; Aldrichina grahami cysteine proteinase. Cat No: EXWM-4195. |  |
| Cathepsin L | Cathepsin L is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Group: Signaling pathways. CAS No. 60616-82-2. Pack Sizes: 25 μg. Product ID: HY-P2923. |  |
| Cathepsin L Active human | recombinant, ?90% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. |  |
| Cathepsin L from human liver | ?0.5 units/mg protein, solution. Group: Fluorescence/luminescence spectroscopy. | |
| Cathepsin L from Human, Recombinant | Cathepsin L (EC 3.4.22.15, Aldrichina grahami cysteine proteinase) is an important lysosomal endopeptidase enzyme which is involved in the initiation of protein degradation. It is a member of the Peptidase C1 family, which play an important role in diverse processes including normal lysosome mediated protein turnover, antigen and proprotein processing, and apoptosis. Cathepsin L has been reported in many organisms including fish, birds and mammals. Group: Enzymes. Synonyms: Cathepsin L1; Major excreted protein; Cathepsin U; Cathepsin V. Enzyme Commission Number: EC 3.4.22.15. Purity: > 90% by SDS-PAGE. CTSL. Mole weight: 24.2 kDa (114-333 aa). Activity: > 10000 mU/mg. Stability: Stable for at least 6 months as supplied. Use as provided or dilute with 50% glycerol to 0.1 mg/ml. Aliquot immediately and store at -80°C. Avoid freeze/thaw cycles. Storage: Store at -80°C. Form: Liquid. Source: E. coli. Species: Human. cathepsin L; CTSL; EC 3.4.22.15; Aldrichina grahami cysteine proteinase; 60616-82-2; Cathepsin L1; Major excreted protein; Cathepsin U; Cathepsin V. Cat No: NATE-1665. | |
| Cathepsin L, Human Liver | Cathepsin L, Human Liver, CAS 60616-82-2, is a native, the most potent of all the lysosomal proteinases. Plays a major role in the proteolysis of both cellular and endocytosed macromolecules. Group: Fluorescence/luminescence spectroscopy. | |
| Cathepsin L Inhibitor | Cathepsin L inhibitor is a potent inhibitor of cathepsin L with IC50 of 0.85 nM. It is trypanocidal with an ED50 value of 45 nM against T. brucei that is well below the ED50 value of 21,500 nM for human HL-60 cells. In vivo, cathepsin L inhibitor (2.5-10 mg/kg) inhibits bone loss in a mouse model of osteoporosis in a dose-dependent manner. Cathepsin L inhibitor can also completely suppress osteoclastic pit formation on femur slices isolated from bovine cortical bone. Synonyms: Z-FY-CHO; Z-Phe-Tyr-aldehyde; SB 412515; N-(benzyloxycarbonyl)-phenylalanyl-l-tyrosinal. Grades: ≥95%. CAS No. 167498-29-5. Molecular formula: C26H26N2O5. Mole weight: 446.49. |  |
| Anti-Cathepsin L antibody, Mouse monoclonal | clone CPL33/1, purified from hybridoma cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| Cathepsin B from human liver | buffered aqueous solution, ?1,500 units/mg protein (E1%/280). Group: Fluorescence/luminescence spectroscopy. | |
| Cathepsin B, Human Liver | Cathepsin B, Human Liver, CAS 9047-22-7, is a purified native cathepsin B from human liver, purified by affinity chromatography. Upregulated in many types of tumors. Group: Fluorescence/luminescence spectroscopy. | |
| Cathepsin D/E Substrate, Fluorogenic | An internally quenched fluorogenic 11-mer peptide that acts as a sensitive and selective substrate for cathepsins D and E, but not cathepsins B, H, or L. Group: Fluorescence/luminescence spectroscopy. | |
| Cathepsin D from human liver | lyophilized powder, ?250 units/mg protein (E1%/280). Group: Fluorescence/luminescence spectroscopy. | |
| Cathepsin H, Human Liver | Cathepsin H, Human Liver, CAS 60748-73-4, is native cathepsin H from human liver that functions both as an aminopeptidase and as an endopeptidase. Group: Fluorescence/luminescence spectroscopy. | |
| Cathepsin S, Human, Recombinant, E. coli | Cathepsin S, Human, Recombinant, E. coli, is prepared without a tag or fusion protein. A major lysosomal cysteine proteinase with high specific activity. Group: Fluorescence/luminescence spectroscopy. | |
| Cathepsin S Substrate, Fluorogenic | An internally quenched, highly cathepsin S-selective, fluorogenic peptide substrate that is efficiently cleaved by CatS, but not by Cathepsin B & L. Group: Fluorescence/luminescence spectroscopy. | |
| Monoclonal Anti-Cathepsin L antibody produced in mouse | clone 33/2, ascites fluid. Group: Fluorescence/luminescence spectroscopy. | |
| Native Human Cathepsin L | Cathepsin L (EC 3.4.22.15, Aldrichina grahami cysteine proteinase) is an important lysosomal endopeptidase enzyme which is involved in the initiation of protein degradation. It is a member of the Peptidase C1 family, which play an important role in diverse processes including normal lysosome mediated protein turnover, antigen and proprotein processing, and apoptosis. Cathepsin L has been reported in many organisms including fish, birds and mammals. Applications: The most powerful of the lysosomal proteinases. it has a higher specific activity than cathepsin b and h in the degradation of a variety of physiological protein substrates. Group: Enzymes. Synonyms: cathepsin L; CTSL; EC 3.4.22.15; Aldrichina grahami cysteine proteinase; 60616-82-2. Enzyme Commission Number: EC 3.4.22.15. CAS No. 60616-82-2. CTSL. Activity: > 0.5 units/mg protein. Storage: -20°C. Form: Solution in in 20 mM malonate, pH 5.5, 1 mM EDTA, and 400 mM NaCl. Source: Human liver. Species: Human. cathepsin L; CTSL; EC 3.4.22.15; Aldrichina grahami cysteine proteinase; 60616-82-2. Cat No: NATE-0177. | |
| 1,1,2-Ethanetricarboxylic Acid 1,1,2-Triethyl Ester | 1,1,2-Ethanetricarboxylic Acid 1,1,2-Triethyl Ester is a useful synthetic intermediate. It can be used to prepare Isobutylsuccinic Acid (I780660) which was used to synthesize succinimide derivatives as inhibitors of human leukocyte elastase, cathepsin G and proteinase 3. Group: Biochemicals. Grades: Highly Purified. CAS No. 7459-46-3. Pack Sizes: 5g, 10g. Molecular Formula: C11H18O6. US Biological Life Sciences. |  Worldwide |
| 1- (2-Hydroxyphenyl) -4- (tert-butoxycarbonyl) piperazine | 1- (2-Hydroxyphenyl) -4- (tert-butoxycarbonyl) piperazine is an intermediate used to synthesize 2-(1-Piperazinyl)-benzenethiol which is used to used to prepare 3,5-dioxo-(2H,4H)-1,2,4-triazine as 5-HT1AR ligands. 1- (2-Hydroxyphenyl) -4- (tert-butoxycarbonyl) piperazine is also used to prepare nonpeptidic biaryl inhibitors of human cathepsin K in relation to treatment of osteoporosis. Group: Biochemicals. Grades: Highly Purified. CAS No. 313657-51-1. Pack Sizes: 1g, 10g. Molecular Formula: C15H22N2O3, Molecular Weight: 278.35. US Biological Life Sciences. | Worldwide |
| 1, ?2-?Piperidinedicarboxyl ?ic Acid 1-?(Phenylmethyl) Ester | 1, ?2-?Piperidinedicarboxyl ?ic Acid 1-?(Phenylmethyl) Ester is used to prepare disubstituted azetidinones as selective inhibitors of cysteine protease cathepsin K. It is also used to synthesize 2-?[(R)?-?2-?methylpyrrolidin-?2-?yl]?-?1H-?benzimidazole-?4-?carboxamide (ABT-?888) as the Poly(ADP-?ribose) Polymerase (PARP) inhibitor for the treatment of cancer. Group: Biochemicals. Grades: Highly Purified. CAS No. 28697-07-6. Pack Sizes: 25g, 100g. Molecular Formula: C14H17NO4, Molecular Weight: 263.29. US Biological Life Sciences. | Worldwide |
| 1,3-Bis-(Z-Leu-Leu)-diaminoacetone | 1,3-Bis-(Z-Leu-Leu)-diaminoacetone, a cysteine protease inhibitor, can specifically and efficiently inhibit the processing of p-Prl signal peptide (IC50 ca. 50 nM) without affecting the activity of signal peptidase and lysosomal cathepsin, proteasome, and other proteases. Synonyms: (Z-LL)2 Ketone; Z-Leu-Leu-NH-CH2-CO-CH2-NH-Leu-Leu-Z; 2,2'-(2-Oxo-1,3-propanediyl)bis[N-[(phenylmethoxy)carbonyl]-L-leucyl-L-leucinamide; 1,3-di-(N-carboxybenzoyl-leucyl-leucyl)aminoacetone; Dibenzyl [(4S,7S,15S,18S)-7,15-diisobutyl-2,20-dimethyl-5,8,11,14,17-pentaoxo-6,9,13,16-tetraazahenicosane-4,18-diyl]biscarbamate. Grades: ≥95%. CAS No. 313664-40-3. Molecular formula: C43H64N6O9. Mole weight: 809.00. | |
| [1- (4-Bromophenyl) cyclopropyl]methanol | Used for preparation of amino acid derivatives as cathepsin cysteine protease inhibitors. Group: Biochemicals. Alternative Names: 1-(4-Bromophenyl)-1-cyclopropanemethanol; 1- (p-Bromophenyl) cyclopropanemethanol. Grades: Highly Purified. CAS No. 98480-31-0. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| 1-Naphthalenylsulfonyl-Ile-Trp-aldehyde | 1-Naphthalenylsulfonyl-Ile-Trp-aldehyde is a potent, reversible, selective and cell-permeable cathepsin L inhibitor with an IC50 of 1.9 nM. It inhibits the release of bone Ca2+ and hydroxyproline in vitro and is useful in the treatment of osteoporosis. Synonyms: N-(1-Naphthalenylsulfonyl)-Ile-Trp-aldehyde; Pentanamide, N-[(1S)-1-formyl-2-(1H-indol-3-yl)ethyl]-3-methyl-2-[(1-naphthalenylsulfonyl)amino]-, (2S,3S)-; N-[(2S)-1-(1H-Indol-3-yl)-3-oxo-2-propanyl]-N2-(1-naphthylsulfonyl)-L-isoleucinamide; N-(1Naphthalenylsulfonyl)-IW-CHO; Cathepsin L Inhibitor IV. Grades: ≥95%. CAS No. 161709-56-4. Molecular formula: C27H29N3O4S. Mole weight: 491.61. | |
| 1-Pyrrolidinyl-3-pyridineacetic Acid | 1-Pyrrolidinyl-3-pyridineacetic Acid is a reagent that is used in the synthesis of phenylalanine cyanomethylamides as cathepsin B inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 933760-99-7. Pack Sizes: 10mg, 100mg. Molecular Formula: C12H15NO2, Molecular Weight: 205.25. US Biological Life Sciences. | Worldwide |
| 1-[ (tert-Butyloxycarbonyl) amino]propane-2, 3-diol | 1-[ (tert-Butyloxycarbonyl) amino]propane-2, 3-diol is a reagent used in the synthesis of analogs of Vestipitant, potent and orally NK1 antagonists. Also, it is the used in the synthesis of N-Boc-2-aminoacetaldehyde (B600600), which is used in the synthesis of carbohydrates as well as studies relating to inhibitors of cathepsin K. Group: Biochemicals. Grades: Highly Purified. CAS No. 137618-48-5. Pack Sizes: 250mg, 1g. Molecular Formula: C8H17NO4, Molecular Weight: 191.22. US Biological Life Sciences. | Worldwide |
| 2-(1-Piperazinyl)-phenol Dihydrochloride | 2-(1-Piperazinyl)-phenol Dihydrochloride, is used to prepare nonpeptidic biaryl inhibitors of human cathepsin K in relation to treatment of osteoporosis. It is also used to synthesize serotonin transporters/histamine H3 receptors. Group: Biochemicals. Grades: Highly Purified. CAS No. 667864-86-0. Pack Sizes: 1g, 10g. Molecular Formula: C10H14N2O 2HCl. US Biological Life Sciences. | Worldwide |
| 2,3,4-Trimethyl-3-pentanol | 2,3,4-Trimethyl-3-pentanol is used to prepare cathepsin K inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 3054-92-0. Pack Sizes: 1g, 5g. Molecular Formula: C8H18O, Molecular Weight: 130.229999999999. US Biological Life Sciences. | Worldwide |
| 2-Amino-2-oxo-acetic Acid Ethyl Ester | 2-Amino-2-oxo-acetic Acid Ethyl Ester is a reagent used to prepare methanotetra hydroiso quinolinecarboxyl ic acid. It can also be used in preparation of 1,2,4-Thiadiazole, a Cathepsin B inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 617-36-7. Pack Sizes: 5g, 10g. Molecular Formula: C4H7NO3, Molecular Weight: 117.1. US Biological Life Sciences. | Worldwide |
| 2-Chloro-3- (trifluoromethyl) benzoic Acid | 2-Chloro-3- (trifluoromethyl) benzoic Acid is a reactant in the preparation of trifluoromethylphenyl as P2 for ketoamide-based cathepsin S inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 39226-97-6. Pack Sizes: 1g, 10g. Molecular Formula: C8H4ClF3O2, Molecular Weight: 224.56. US Biological Life Sciences. | Worldwide |
| 2-Chloro-N-methoxy-N-methylbenzamide | 2-Chloro-N-methoxy-N-methylbenzamide was used as a reagent in the synthesis of functionalized β-oxonitriles. Also used in the synthesis of potent thiosemicarbazone based cathepsin L inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 289686-74-4. Pack Sizes: 500mg, 1g. Molecular Formula: C9H10ClNO2, Molecular Weight: 199.63. US Biological Life Sciences. | Worldwide |
| 2-Pyrimidinecarbonitrile | Cathepsin K is a lysosomal cysteine protease found in osteoclasts whose elevated activity has been linked to the formation of osteoporosis and arthritis. 2-cyano-Pyrimidine is a cathepsin K inhibitor. Synonyms: pyrimidine-2-carbonitrile. Grades: 95+%. CAS No. 14080-23-0. Molecular formula: C5H3N3. Mole weight: 105.10. | |
| (2R,?3R)?-2-Bromo-3-hydroxybutanedioic Acid 1,4-Diethyl Ester | (2R,?3R)?-2-Bromo-3-hydroxybutanedioic Acid 1,4-Diethyl Ester is an intermediate in the synthesis of derivative of E-64 an inhibitor of cathepsins B and L as well as a potential inhibitor of calpain. Group: Biochemicals. Grades: Highly Purified. CAS No. 80640-15-9. Pack Sizes: 1g, 5g. Molecular Formula: C8H13BrO5. US Biological Life Sciences. | Worldwide |
| (2R)-4-Phenylbutan-2-amine-d3 | (2R)-4-Phenylbutan-2-amine is an isotope labelled intermediate in the synthesis of potent Cathepsin S inhibitor. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg, 25mg. Molecular Formula: C10H12D3N. US Biological Life Sciences. | Worldwide |
| (2R)-4-Phenylbutan-2-amine p-Toluenesulfonic Acid | (2R)-4-Phenylbutan-2-amine p-Toluenesulfonic Acid is an intermediate in the synthesis of potent Cathepsin S inhibitor. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 5mg. Molecular Formula: C17H23NO3S. US Biological Life Sciences. | Worldwide |
| (2S, 3S) -3- [ [ [ (1S) -1- [ [ (4-Azidobutyl) amino] carbonyl] -3-methylbutyl] amino] carbonyl] -2-oxiranecarboxylic Acid Ethyl Ester | N3Le is a derivative of E-64 an inhibitor of cathepsins B and L as well as a potential inhibitor of calpain. E-64d has been shown to inhibit lysosomal proteases. Group: Biochemicals. Grades: Highly Purified. CAS No. 1174021-95-4. Pack Sizes: 1mg, 10mg. Molecular Formula: C16H27N5O5. US Biological Life Sciences. | Worldwide |
| 3-Cyano-1,2,4-triazole | A cyano substituted triazole with inhibitory effects on cathepsin K used in a study of the electrophilicity and reactivity of diverse nitrile-containing compounds and its correlation to the mechanism-of-action. Group: Biochemicals. Alternative Names: 1H-1,2,4-Triazole-3-carbonitrile; s-Triazole-3-carbonitrile. Grades: Highly Purified. CAS No. 3641-10-9. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
| 3-epi-Ursolic Acid | 3-epi-Ursolic Acid is a potent inhibitor against glycogen phosphorylase which makes it a potential rug for treatment of type-2 diabetes and other diseases associated with glycogen metabolism. It is also a part of the group of triterpenoids that act as novel inhibitors of Human Cathepsin L. Group: Biochemicals. Grades: Highly Purified. CAS No. 989-30-0. Pack Sizes: 5mg, 10mg. Molecular Formula: C30H48O3, Molecular Weight: 456.7. US Biological Life Sciences. | Worldwide |
| 3-Iodo-N-[(benzyloxy)carbonyl]-L-tyrosine | 3-Iodo-N-[(benzyloxy)carbonyl]-L-tyrosine is a reactant used in the preparation of diazonamide A and peptidyl and azapeptidyl Me ketones as substrate analog inhibitors of papain and cathepsin B. Group: Biochemicals. Alternative Names: 3-Iodo-N-[ (phenylmethoxy) carbonyl]-L-tyrosine. Grades: Highly Purified. CAS No. 79677-62-6. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| 5-Nitro-8-hydroxyquinoline | 5-Nitro-8-hydroxyquinoline is an antimicrobial agent used for the treatment of urinary tract infection. 5-Nitro-8-hydroxyquinoline is also a potent and reversible inhibitor of cathepsin B. 5-Nitro-8-hydroxyquinoline has been shown to have anti-cancer activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 4008-48-4. Pack Sizes: 10g, 25g, 100g, 250g. Molecular Formula: C?H?N?O?, Melting Point: >179ºC (dec.). US Biological Life Sciences. | Worldwide |
| Abz-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (669-674)-EDDnp | Abz-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (669-674)-EDDnp is an intramolecularly quenched fluorescent substrate with the ortho-aminobenzoyl (Abz)/N-(2,4-dinitrophenyl)ethylenediamine (EDDnp) groups as the donor/acceptor pair. It corresponds to the Swedish-mutated (JMV2236) β-amyloid precursor protein (βAPP) sequence, which is targeted by β-secretase BACE (β-site APP-cleaving activity). It is more selectively cleaved by BACE1 and BACE2 than by cathepsin D, a disintegrin and metalloprotease 10 (ADAM10), tumor necrosis α-converting enzyme (TACE), presenilin-1 (PS1), or presenilin-2 (PS2). Synonyms: JMV2236; L-α-Glutamine, N-(2-aminobenzoyl)-L-valyl-L-asparaginyl-L-leucyl-L-α-aspartyl-L-alanyl-N-[2-[(2,4-dinitrophenyl)amino]ethyl]-; N-(2-Aminobenzoyl)-L-valyl-L-asparaginyl-L-leucyl-L-α-aspartyl-L-alanyl-N-{2-[(2,4-dinitrophenyl)amino]ethyl}-L-α-glutamine. Grades: ≥95%. CAS No. 1007306-20-8. Molecular formula: C42H58N12O16. Mole weight: 986.99. | |
| Abz-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH | Abz-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH is a very efficient and selective FRET substrate for human cathepsin B (Km = 5.9 μM, kcat = 43 s-1, kcat/Km = 7288 mM-1s-1), with kcat/Km values of 133.3, 100, 32, 17, and 75 mM-1s-1 for cathepsin K, L, V, X, and cruzain, respectively. Synonyms: H-2Abz-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH; Abz-GIVRAK(Dnp); L-Lysine, N-(2-aminobenzoyl)glycyl-L-isoleucyl-L-valyl-L-arginyl-L-alanyl-N6-(2,4-dinitrophenyl)-; N-(2-Aminobenzoyl)glycyl-L-isoleucylvalyl-L-arginyl-L-alanyl-N6-(2,4-dinitrophenyl)-L-lysine. Grades: ≥95%. CAS No. 827044-38-2. Molecular formula: C41H61N13O12. Mole weight: 928.02. | |
| Acetyl-Calpastatin(184-210)(human) | Acetyl-Calpastatin(184-210)(human) is a potent, selective and reversible calpain inhibitor with K i values of 0.2 nM and 6 μM for μ-calpain and cathepsin L, respectively [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 123714-50-1. Pack Sizes: 500 μg; 1 mg; 5 mg; 10 mg. Product ID: HY-P1081. | |
| Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH2 | Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH2 is a sensitive fluorescent (FRET) peptide substrate for cathepsin D. This enzyme degrades extracellular matrix components and may promote the spread of tumor cells. High levels of active cathepsin D were found in senile plaques in the brains of Alzheimer's patients. Synonyms: L-α-Glutamine, N-acetyl-L-α-glutamyl-N-[2-[(5-sulfo-1-naphthalenyl)amino]ethyl]-L-asparaginyl-L-lysyl-L-prolyl-L-isoleucyl-L-leucyl-L-phenylalanyl-L-phenylalanyl-L-arginyl-L-leucylglycyl-N6-[4-[[4-(dimethylamino)phenyl]azo]benzoyl]-L-lysyl-; N-Acetyl-L-α -glutamyl-N-{2-[ (5-sulfo-1-naphthyl) amino]ethyl}-L-asparaginyl-L-lysyl-L-prolyl-L-isoleucyl-L-leucyl-L-phenylalanyl-L-phenylalanyl-L-arginyl-L-leucylglycyl-N6- (4-{[4- (dimethylamino) phenyl]diazenyl}benzoyl) -L-lysyl-L-α -glutamine. Grades: ≥95%. CAS No. 400716-78-1. Molecular formula: C104H146N24O23S. Mole weight: 2132.52. | |
| Ala-Ala-OMe HCl | Substrate for dipeptidyl aminopeptidase I (cathepsin C). Synonyms: L-Alanyl-L-alanine methyl ester hydrochloride. Grades: ≥ 98% (TLC). CAS No. 41036-19-5. Molecular formula: C7H14N2O3·HCl. Mole weight: 210.66. | |
| ALLM - CAS 110115-07-6 | Cell permeable inhibitor of calpain I (Ki = 120 nM), calpain II (Ki = 230 nM), cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 600 pM). Group: Fluorescence/luminescence spectroscopy. | |
| ALLN - CAS 110044-82-1 | Cell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM). Group: Fluorescence/luminescence spectroscopy. | |
| Aloxistatin | Aloxistatin is an inhibitor of cathepsins B and L as well as a potential inhibitor of calpain, which predicted to function against SARS-CoV-2 infection. Synonyms: L-trans-Epoxysuccinyl(OEt)-Leu-3-methylbutylamide; L-trans-Epoxysuccinyl-Leu-3-methylbutylamide-ethyl ester; (2S, 3S) -3-[[[ (1S) -3-Methyl-1-[[ (3-methylbutyl) amino]carbonyl]butyl]amino]carbonyl]-2-oxiranecarboxylic Acid Ethyl Ester; E 64c ethyl ester; E 64d; EP 453; EST; Loxistatin; NSC 694281; (2S,3S)-trans-Epoxysuccinyl-L-leucylamido-3-methylbutane ethyl ester. Grades: 98%. CAS No. 88321-09-9. Molecular formula: C17H30N2O5. Mole weight: 342.43. | |
| Aminopeptidase N Inhibitor | Membrane alanyl aminopeptidase is also known as alanyl aminopeptidase (AAP) or aminopeptidase N (AP-N), which is an enzyme that in humans is encoded by the ANPEP gene. Aminopeptidase N (AP-N) inhibitor is a reversible inhibitor of AP-N/CD13 (IC50 = 25 μM). It is selective for AP-N/CD13 over matrix metalloproteinase-9 (MMP-9), angiotensin converting enzyme (ACE), neutral endopeptidase (NEP), γ-glutamyl transpeptidase, and the serine proteases dipeptidyl peptidase 4 (DPP-4) and cathepsin G at a concentration of 1 mM. AP-N inhibitor is non-cytotoxic to U937 cells at a concentration of 100 μM. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. Synonyms: AP-N Inhibitor. Grades: ≥95%. CAS No. 596108-59-7. Molecular formula: C17H10N2O8. Mole weight: 370.27. | |
| Aurantiamide acetate | Aurantiamide acetate (TMC-58A) is a selective and orally active cathepsin inhibitor isolated from Portulaca oleracea L. Aurantiamide acetate has anti-inflammatory activities and can be used for the study of inflammatory diseases [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Asperglaucide. CAS No. 56121-42-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N2905. | |
| AZD3839 free base | AZD3839 free base is a potent and selective orally active, brain-permeable BACE1 inhibitor ( K i=26 nM). AZD3839 free base shows 14 and >1000-fold selectivity against BACE2 and cathepsin D, respectively. AZD3839 free base exhibits dose- and time-dependent lowering of plasma, brain, and cerebrospinal fluid Aβ levels in mouse, guinea pig, and non-human primate. AZD3839 free base can be used for the research of Alzheimer's disease [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1227163-84-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-13438. | |
| Baker's yeast (S. cerevisiae) Carboxypeptidase Y, recombinant | Carboxypeptidase Y (CPY) catalyzes the following reaction: Peptidyl-L-amino acid + H2O ------> Peptide + L-amino acid.It is prepared according to the method of Moore & Stein (J. Biol Chem, 211, 907, 1954). It resembles Carboxypeptidase A in its substrate specificity, but it hydrolyzes C-terminal glycine and L-leuicine more rapidly and L-phenylalanine more slowly. Group: Enzymes. Synonyms: carboxypeptidase Y; serine carboxypeptidase I; cathepsin A; lysosomal protective protein; deamidase; lysosomal carboxypeptidase A; phaseolin; EC 3.4.16.5; 9046-67-7; Peptidyl-L-amino acid Hydrolase; Serine Carboxypeptidase; Carboxypeptidase C; Peptidyl-L. Enzyme Commission Number: EC 3.4.16.1. Purity: > 90 %. Carboxypeptidase Y. Activity: > 10u/mg. Appearance: Clear, colorless to lightly colored. Storage: Long term below -20°C, short term 2-8°C. Avoid multiple freeze-thaws. Form: 500 mM sodium chloride, 500 mM imidazole, 20 mM sodium phosphate monobasic, 20 mM sodium phosphate dibasic, pH 7.5. Species: S. cerevisiae. carboxypeptidase Y; serine carboxypeptidase I; cathepsin A; lysosomal protective protein; deamidase; lysosomal carboxypeptidase A; phaseolin; EC 3.4.16.5; 9046-67-7; Peptidyl-L-amino acid Hydrolase; Serine Carboxypeptidase; Carboxypeptidase C; Peptidyl-L-amino-acid (-L-proline ) hydrolase; EC 3.4.12.8. Cat No: NATE-0103. | |
| Balicatib | The cathepsin K inhibitor AAE-581 (balicatib) as the most advanced of them passed Phase II clinical trials in 2005. Eighty adult female Macaca fascicularis underwent bilateral ovariectomies and were dosed twice daily by oral gavage with balicatib at 0, 3, 10, and 50 mg/kg for 18 months (groups O, L, M, H, respectively). Approximately 1 month after treatment initiation, the 50 mg/kg dose was decreased to 30 mg/kg. Twenty animals underwent sham-ovariectomies (group S). Bone mass was measured at 3-6 month intervals. At 18 months, vertebra and femur were collected for histomorphometry. Synonyms: AAE581; AAE-581; AAE 581. Grades: 0.98. CAS No. 354813-19-7. Molecular formula: C23H33N5O2. Mole weight: 411.54. | |
| β-Cyclopentyl-L-alanine | β-Cyclopentyl-L-alanine is used as a reagent in the synthesis of functionalized N-arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Synonyms: β-Cyclopentyl-L-Ala-OH; (S)-2-Amino-3-cyclopentylpropanoic acid; 3-Cyclopentane-L-alanine; L-3-Cyclopentylalanine; H-Cpa-OH; (2S)-2-amino-3-cyclopentylpropanoic acid; 3-cyclopentylalanine; H-Ala(cPen)-OH; (S)-alfa-Amino-cyclopentanepropanoic acid; beta-cyclopentyl-l-alanine; beta-Cyclopentyl-L-Ala-OH; H Cpa OH. Grades: ≥ 99.5%. CAS No. 99295-82-6. Molecular formula: C8H15NO2. Mole weight: 157.09. | |
| Biotin-FF-FMK | Biotin-FF-FMK is a biotin-labeled cathepsin inhibitor that selectively suppresses cathepsin B and cathepsin L. Synonyms: Biotin-Phe-Phe-CH2F; Biotin-Phe-Phe-Fluoromethylketone. Grades: ≥95%. Molecular formula: C29H35FN4O4S. Mole weight: 554.68. | |
| Biotin-LLY-FMK | Biotin-LLY-FMK is a biotin-labeled calpain inhibitor that can be used as a probe for detecting calpain II and cathepsin L by biotin ligand. Synonyms: Biotin-Leu-Leu-Tyr-Fluoromethylketone. Grades: ≥95%. Molecular formula: C32H48FN5O6S. Mole weight: 649.82. | |
| Boc-3-(2-naphthyl)-L-alanine | Boc-3-(2-naphthyl)-L-alanine functions as a reagent for the synthesis of dipeptidyl nitriles as potent and reversible inhibitors of Cathepsin C. Synonyms: Boc-L-Ala(2-naphthyl)-OH; Boc-2-Nal-OH; N-(tert-Butoxycarbonyl)-3-(2-naphthyl)-L-alanine; Boc-3-(2 naphthyl)-L-alanine; BOC-2-L-NAPHTHYLALANINE; (2S)-2-{[(tert-butoxy)carbonyl]amino}-3-(naphthalen-2-yl)propanoic acid; Boc-L-2-Naphthylalanine; N-Boc-3-(2-naphthyl)-L-alanine; (S)-2-((tert-butoxycarbonyl)amino)-3-(naphthalen-2-yl)propanoic acid. Grades: ≥ 99.5% (Chiral HPLC). CAS No. 58438-04-3. Molecular formula: C18H21NO4. Mole weight: 315.36. | |
| Boc-L-glutamine 4-nitrophenyl ester | A substrate for cathepsin B. Synonyms: Boc-L-Gln-ONp. Grades: ≥ 98% (HPLC). CAS No. 15387-45-8. Molecular formula: C16H21N3O7. Mole weight: 367.40. | |
| Boc-Phe-aldehyde | A human cathepsin K inhibitor. Synonyms: Boc-Phe-CHO; N-Boc-L-phenylalaninal; N-Boc-phenylalaninal; N-α-(t-Butoxycarbonyl)-L-phenylalaninal. Grades: 95 %. CAS No. 72155-45-4. Molecular formula: C14H19NO3. Mole weight: 249.31. | |
| Bz-Arg-Gly-Phe-Phe-Leu-4MbetaNA | A substrate for cathepsin D. Synonyms: benzoyl-Arg-Gly-Phe-Phe-Leu-MNA; Bz-Arg-Gly-Phe-Phe-Leu-4-methoxy-beta-naphthylamide; Bz-RGFFL-MNA. CAS No. 99112-24-0. Molecular formula: C50H59N9O7. Mole weight: 898.06. | |
| CA 074 | CA 074 is a potent and selective inhibitor of cathepsin B (Ki = 2-5 nM). It reduces bone metastasis in a 4T1.2 breast cancer model. Uses: Cysteine proteinase inhibitors. Synonyms: CA-074; CA074; CA 074; N-[[(2S,3S)-3-[(Propylamino)carbonyl]-2-oxiranyl]carbonyl]-L-isoleucyl-L-proline. Grades: ≥98% by HPLC. CAS No. 134448-10-5. Molecular formula: C18H29N3O6. Mole weight: 383.44. | |
| CA 074 (N-[[(2S,3S)-3-[(Propylamino)carbony l]-2-oxiranyl]carbonyl]-L-isoleucyl-L-proline) | Inhibitor of cathepsin B (Ki = 2-5nm). Displays selectivity over cathepsins H and L (Ki = 40-200um). Shown to reduce bone metastasis in a 4T1.2 breast cancer model. Group: Biochemicals. Grades: Highly Purified. CAS No. 134448-10-5. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Calpain Inhibitor II | Calpain inhibitor II is a cell-permeable inhibitor of calpain I (Ki = 120 nM), calpain II (Ki = 230 nM), cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 600 pM). It inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Calpain inhibitor II can block nitric oxide production by interfering with transcription of the inducible nitric oxide synthase gene, which is a weak inhibitor of proteasome. It has been used to demonstrate the involvement of ubiquitin-proteasome protein degradation in various biological systems. Uses: Cysteine proteinase inhibitors. Synonyms: L-Leucinamide, N-acetyl-L-leucyl-N-[(1S)-1-formyl-3-(methylthio)propyl]-; L-Leucinamide, N-acetyl-L-leucyl-N-[1-formyl-3-(methylthio)propyl]-, (S)-; N-Acetyl-L-leucyl-N-[(1S)-1-formyl-3-(methylthio)propyl]-L-leucinamide; ALLM; Calp II; CI 2; SUAM 312; N-acetylleucyl-leucyl-methioninal; Ac-Leu-Leu-Met-al; N-acetyl-L-leucyl-L-leucyl-L-methioninal. Grades: ≥98%. CAS No. 110115-07-6. Molecular formula: C19H35N3O4S. Mole weight: 401.57. | |
| Calpain Inhibitor XII | Calpain Inhibitor XII is a cell-permeable, potent, selective, reversible, and active-site-directed inhibitor of calpain-1 with Ki of 19 nM. It has been shown to inhibit calpain-2 with Ki of 120 nM and human cathepsin B with Ki of 750 nM. Calpain inhibitor XII has been used to study the role of calpains in diverse processes, including neutrophil chemotaxis, neuronal signaling, and cardiac response to injury. Synonyms: Z-L-Nva-CONH-CH2-2-Py. Grades: ≥90%. CAS No. 181769-57-3. Molecular formula: C26H34N4O5. Mole weight: 482.6. | |
| carboxypeptidase C | A carboxypeptidase with optimum pH 4.5-6.0, inhibited by diisopropyl fluorophosphate, and sensitive to thiol-blocking reagents (reviewed in). Widely distributed in eukaryotes. Type example of peptidase family S10. Group: Enzymes. Synonyms: carboxypeptidase Y; serine carboxypeptidase I; cathepsin A; lysosomal protective protein; deamidase; lysosomal carboxypeptidase A; phaseolin. Enzyme Commission Number: EC 3.4.16.5. CAS No. 9046-67-7. Carboxypeptidase Y. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4059; carboxypeptidase C; EC 3.4.16.5; 9046-67-7; carboxypeptidase Y; serine carboxypeptidase I; cathepsin A; lysosomal protective protein; deamidase; lysosomal carboxypeptidase A; phaseolin. Cat No: EXWM-4059. | |
| cathepsin B | An intracellular (lysosomal) enzyme in peptidase family C1 (papain family). Group: Enzymes. Synonyms: cathepsin B1 (obsolete); cathepsin II. Enzyme Commission Number: EC 3.4.22.1. CAS No. 9047-22-7. Cathepsin B. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4192; cathepsin B; EC 3.4.22.1; 9047-22-7; cathepsin B1 (obsolete); cathepsin II. Cat No: EXWM-4192. | |
| Cathepsin B from Human, recombinant | Cathepsin B is a lysosomal cysteine protease. It is implicated in playing a role in protein degradation, arthritis, apoptosis, and cancer. Group: Enzymes. Synonyms: CTSB; 9047-22-7; APPS; CPSB; cathepsin B1 (obsolete); cathepsin II. Enzyme Commission Number: EC 3.4.22.1. CAS No. 9047-22-7. Purity: > 90% by SDS-PAGE. Cathepsin B. Mole weight: 27.8 kDa (80-333 aa). Activity: >7500 mU/mg. Storage: Stable for at least 1 year as supplied. Dilute in de-ionized water to 0.1 mg/ml and store at -80°C. Avoid repeated freezing and thawing cycles. Form: Liquid. Source: E. coli. Species: Human. CTSB; cathepsin B; 9047-22-7; APPS; CPSB; cathepsin B1 (obsolete); cathepsin II; EC 3.4.22.1. Cat No: NATE-1706. | |
| cathepsin D | Occurs intracellularly, in lysosomes. A zymogen form is known. In peptidase family A1 (pepsin A family). Group: Enzymes. Enzyme Commission Number: EC 3.4.23.5. CAS No. 9025-26-7. CTSD. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4287; cathepsin D; EC 3.4.23.5; 9025-26-7. Cat No: EXWM-4287. | |
| CATHEPSIN D | CATHEPSIN D. Uses: Designed for use in research and industrial production. Additional or Alternative Names: CATHEPSIN D;CATHEPSIN D, BOVINE;CATHEPSIN D, BOVINE KIDNEY;CATHEPSIN D, BOVINE SPLEEN;CATHEPSIN D, HUMAN;CATHEPSIN D, HUMAN LIVER;CATHEPSIN D, HUMAN SPLEEN;EC 3.4.22.5. Product Category: Heterocyclic Organic Compound. CAS No. 9025-26-7. Molecular formula: C15H16O3S. Mole weight: 276.35074;g/mol. Purity: 0.96. IUPACName: 2-(3-hydroxybutan-2-ylsulfanyl)-3-methylnaphthalene-1,4-dione. Canonical SMILES: CC1=C(C(=O)C2=CC=CC=C2C1=O)SC(C)C(C)O. Product ID: ACM9025267. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Cathepsin D from Human, recombinant | Cathepsin D is a lysosomal aspartyl protease composed of a protein dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is an estrogen-regulated protein associated with tissue breakdown. Levels of cathepsin D have been positively correlated with recurring breast cancers of both node negative and node positive types. Additionally cathepsin D has been associated with amyloid formation in Alzheimer's plaques. Cathepsin D is produced initially as a pre-pro-enzyme which gets transported to lysosomes via endosomes in most cell types. In endosomes, it gets proteolyzed by unidentified proteases by removal of the pro-peptide to generate...e cathepsins B and L generates mature, active double-chain Cathepsin D. Group: Enzymes. Synonyms: CTSD; 9025-26-7; EC 3.4.23.5; CLN10; CPSD; HEL-S-130P; Procathepsin D. Enzyme Commission Number: EC 3.4.23.5. CAS No. 9025-26-7. Purity: > 80% by SDS-PAGE. CTSD. Mole weight: 45.1 kDa. Activity: >100 pmol/min/mg. Storage: Store at -20°C. Stable for at least 6 months as supplied. Reconstitute to 1 mg/ml in sterile water, store at -80°C in aliquots and use within 6 months after reconstitution. Avoid repeated freeze-thaw cycles. Form: Freeze-Dried. Source: E. coli. Species: Human. CTSD; cathepsin D; 9025-26-7; EC 3.4.23.5; CLN10; CPSD; HEL-S-130P; Procathepsin D. Cat No: NATE-1707. | |
| cathepsin E | Found in stomach, spleen, erythrocyte membrane; not lysosomal. Pro-cathepsin E is an 86 kDa disulfide-linked dimer; activation or reduction produces monomer. In peptidase family A1 (pepsin A family). Group: Enzymes. Synonyms: slow-moving proteinase; erythrocyte membrane aspartic proteinase; SMP; erythrocyte membrane aspartic proteinase; EMAP; non-pepsin proteinase; cathepsin D-like acid proteinase; cathepsin E-like acid proteinase; cathepsin D-type proteinase. Enzyme Commission Number: EC 3.4.23.34. CAS No. 110910-42-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4271; cathepsin E; EC 3.4.23.34; 110910-42-4; slow-moving proteinase; erythrocyte membrane aspartic proteinase; SMP; erythrocyte membrane aspartic proteinase; EMAP; non-pepsin proteinase; cathepsin D-like acid proteinase; cathepsin E-like acid proteinase; cathepsin D-type proteinase. Cat No: EXWM-4271. | |
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