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| Product | Description | |
|---|---|---|
| CCR1 antagonist | CCR1 antagonist is a chemokine CCR1 antagonist. It is used for the treatment of chronic obstructive pulmonary disease. Uses: Ccr1 antagonist is used for the treatment of chronic obstructive pulmonary disease. Synonyms: AZD-4818; AZD 4818; AZD4818. (S)-2-(2-chloro-5-(3-(5-chloro-3H-spiro[benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropoxy)-4-(methylcarbamoyl)phenoxy)-;2-[2-Chloro-5-[(2S)-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-4-(methylcarbamoyl)phenoxy]-2-methylpropanoic acid. Grades: >98 %. CAS No. 1003566-93-5. Molecular formula: C27H32Cl2N2O7. Mole weight: 567.46. |  |
| (1R, 3S) -3-Aminocyclopentane carboxylic Acid | (1R, 3S) -3-Aminocyclopentane carboxylic Acid is used in the synthesis of aminocyclopentane carboxylic acid-containing cyclic RGD peptides. It is also used to prepare BMS-457, a potent and selective CCR1 antagonist. Group: Biochemicals. Grades: Highly Purified. CAS No. 71830-08-5. Pack Sizes: 100mg, 250mg. Molecular Formula: C6H11NO2, Molecular Weight: 129.16. US Biological Life Sciences. |  Worldwide |
| 2-Ethyl-4-methyl-pentyl Salicylate | 2-Ethyl-4-methyl-pentyl Salicylate is made from 4-Methylvaleric Acid (M338545), which is a versatile building block used in the synthesis of various pharmaceutical and biologically active compounds, including inhibitors and antagonists. It is involved in the synthesis of novel series of high affinity, functionally potent antagonists of the CCR1 receptor. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg, 25mg. Molecular Formula: C15H22O3, Molecular Weight: 250.33. US Biological Life Sciences. | Worldwide |
| 2-(Trifluoromethyl)-benzeneacetonitrile | 2-(Trifluoromethyl)-benzeneacetonitrile was used to prepare non-peptide CCR1 receptor antagonists. It was also used to synthesize cyclopentimidazopyridi none and related compounds as interleukin-6 inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 3038-47-9. Pack Sizes: 2.5g, 10g. Molecular Formula: C9H6F3N, Molecular Weight: 185.15. US Biological Life Sciences. | Worldwide |
| 3-Iodo-1H-pyrazolo[3,4-b]pyridine | Used for preparation of azaindazole compounds as CCR1 antagonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 117007-52-0. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
| 3-m-Tolylpropanoic Acid | 3-m-Tolylpropanoic Acid is used in the synthesis of piperidine antagonists as CCR1-selective inhibitors. via parallel synthesis. Also used in the synthesis of small molecule antagonists of vasoactive intestinal. peptide receptor1 (VIPR1). Group: Biochemicals. Alternative Names: Hydrocinnamic acid, m-methyl-(7CI,8CI); 3-(3-Methylphenyl)propanoic acid; 3-(3-Methylphenyl)propionic Acid; 3-Methyl- β-phenylpropionic Acid; 3-Methylbenzenepropanoic Acid; 3-Methylhydrocinnamic Acid; 3-m-Tolylpropionic Acid; m-Methylhydrocinnamic Acid. Grades: Highly Purified. CAS No. 3751-48-2. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
| A1B1 hydrochloride | A1B1 hydrochloride is a potent and orally-available chemokine CCR1 antagonist. Synonyms: N-[5-chloro-2-[(E)-3-[(2R)-4-[(4-fluorophenyl)methyl]-2-methylpiperazin-1-yl]-3-oxoprop-1-enyl]phenyl]acetamide hydrochloride. Grades: 99%. Molecular formula: C23H25ClFN3O2.HCl. Mole weight: 466.38. | |
| AZD-4818 | AZD-4818 is a chemokine CCR1 antagonist that is used for the treatment of chronic obstructive pulmonary disease. Uses: Designed for use in research and industrial production. Additional or Alternative Names: AZD-4818; AZD 4818; AZD4818. Product Category: Antagonists. Appearance: Solid powder. CAS No. 1003566-93-5. Molecular formula: C27H32Cl2N2O7. Mole weight: 567.46. Purity: >98%. IUPACName: (S)-2-(2-chloro-5-(3-(5-chloro-3H-spiro[benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropoxy)-4-(methylcarbamoyl)phenoxy)-. Canonical SMILES: CC(C)(OC1=CC(OC[C@@H](O)CN2CCC3(CC2)OC4=CC=C(Cl)C=C4C3)=C(C(NC)=O)C=C1Cl)C(O)=O. Product ID: ACM1003566935. Alfa Chemistry ISO 9001:2015 Certified. |  |
| BI 639667 | BI 639667 (compound 19n), a third azaindazole series compound, is a CCR1 antagonist, with an IC 50 of 1.8 nM in Ca 2+ flux assay [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CCR1 antagonist 8. CAS No. 1295298-26-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-120588. |  |
| BX471 | BX471 (ZK-811752) is an orally active, potent and selective non-peptide CCR1 antagonist with a Ki of 1 nM, and exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ZK-811752. CAS No. 217645-70-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-12080. | |
| BX 471 | BX 471 is a selective CCR1 antagonist. Synonyms: (R)-1-(5-chloro-2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)phenyl)urea; BX471; BX 471; BX-471; ZK811752; ZK 811752; ZK-811752. CAS No. 217645-70-0. Molecular formula: C21H24ClFN4O3. Mole weight: 434.89. | |
| BX-471 | BX-471, also known as ZK-811752, is a potent, selective non-peptide CCR1 antagonist (Ki = 1 nM for human CCR1). BX-471 exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4. BX-471 was developed Berlex and its parent company, Schering AG. BX-471 is the lead in a series of non-peptide chemokine receptor 1 (CCR1) antagonists, for the potential treatment of autoimmune diseases, in particular multiple sclerosis (MS). In March 2000, BX-471 was undergoing phase I trials for the potential treatment of autoimmune diseases. Uses: Designed for use in research and industrial production. Additional or Alternative Names: BX471; BX 471; BX-471; ZK811752; ZK 811752; ZK-811752. Product Category: Antagonists. Appearance: Solid powder. CAS No. 217645-70-0. Molecular formula: C21H24ClFN4O3. Mole weight: 434.89. Purity: >98%. IUPACName: (R)-1-(5-chloro-2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)phenyl)urea. Canonical SMILES: C[C@H]1N(C(COC2=CC=C(Cl)C=C2NC(N)=O)=O)CCN(CC3=CC=C(F)C=C3)C1. Product ID: ACM217645700. Alfa Chemistry ISO 9001:2015 Certified. Categories: Bx41 (New York City bus). | |
| BX471 hydrochloride | BX471 hydrochloride is a potent, selective non-peptide CCR1 antagonist (Ki = 1 nM for human CCR1). Synonyms: BX-471 hydrochloride; BX 471 hydrochloride; (R)-1-(5-chloro-2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)phenyl)urea hydrochloride. CAS No. 288262-96-4. Molecular formula: C21H25Cl2FN4O3. Mole weight: 471.35. | |
| BX 513 hydrochloride | BX 513 hydrochloride is a selective CCR1 receptor antagonist (Ki = 0.04, > 10, > 10 and > 10 nM for CCR1, CCR5, CXCR2 and CXCR4 receptors, respectively), and also acts as a US28 agonist. It inhibits MIP-1α-induced intracellular calcium mobilization (IC50 = 2.5 μM). Synonyms: BX-513 hydrochloride; BX513 hydrochloride; 1-Piperidinepentanenitrile, 4-(4-chlorophenyl)-4-hydroxy-α,α-diphenyl-, hydrochloride (1:1); 4-(4-Chlorophenyl)-4-hydroxy-α,α-diphenyl-1-piperidinepentanenitrile hydrochloride; VUF 2274 hydrochloride; 5-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidyl]-2,2-diphenyl-pentanenitrile hydrochloride. Grades: ≥99% by HPLC. CAS No. 1216540-18-9. Molecular formula: C28H29ClN2O.HCl. Mole weight: 481.46. | |
| (-)-cis-3-Aminocyclopentanecarboxylic acid | (-)-(1R,3S)-3-Aminocyclopentanecarboxylic acid is used in the synthesis of aminocyclopentanecarboxylic acid-containing cyclic RGD peptides. It is also used to prepare BMS-457, a potent and selective CCR1 antagonist. Synonyms: (-)-(1R,3S)-3-Aminocyclopentanecarboxylic acid; Cyclopentanecarboxylic acid, 3-amino-, (1R,3S)-; (1R,3S)-3-Aminocyclopentanecarboxylic acid; Cyclopentanecarboxylic acid, 3-amino-, (1R-cis)-; (1R,3S)-3-Aminocyclopentanecarboxylic acid. Grades: ≥95%. CAS No. 71830-08-5. Molecular formula: C6H11NO2. Mole weight: 129.16. | |
| CP-481715 | CP-481715 is a potent and selective CCR1 antagonist with >100-fold selective for CCR1 as compared with a panel of G-protein-coupled receptors including related chemokine receptors. CP-481,715 inhibits cell infiltration and inflammatory responses in human CCR1 transgenic mice. Synonyms: N-[(2S,3S,5R)-5-carbamoyl-1-(3-fluorophenyl)-3,8-dihydroxy-8-methylnonan-2-yl]quinoxaline-2-carboxamide; CP 481,715; CP 481715; CP-481,715; CP-481715; CP481,715; CP481715; quinoxaline-2-carboxylic acid (4-carbamoyl-1-(3-fluorobenzyl)-2,7-dihydroxy-7-methyloctyl)amide. Grades: >98%. CAS No. 212790-31-3. Molecular formula: C26H31FN4O4. Mole weight: 482.55. | |
| Di-tert-butyliminodicarboxylate | Di-tert-butyl iminodicarboxylate is a protected amine group that is used to prepare conformationally constrained spirocycles as CCR1 antagonists. Synonyms: (Boc)2NH; is(Boc)amine; Bis(tert-butoxycarbonyl)amine; Di-tert-butyl Imidodicarbonate; Di-tert-butyl imidodicarboxylate; Iminodicarboxylic Acid Di(tert-butyl) Ester; NSC 131088; tert-Butyl N-(tert-butoxycarbonyl)carbamate; Imidodicarbonic acid, Bis(1,1-dimethylethyl) Ester; Imidodicarboxylic Acid, Di-tert-butyl Ester; tert-Butyl iminodicarboxylate; N-Boc-tert-butylcarbamate; di(tert-butyl) imidodicarbonate; diboc amine; Di-tert-butyliminodicarboxylate; di-boc-amine; bis-Boc amine. Grades: > 95 % (GC). CAS No. 51779-32-9. Molecular formula: C10H19NO4. Mole weight: 217.26. | |
| J 113863 | J 113863 is a potent CCR1 antagonist. Synonyms: J 113863; J-113863; J113863; UCB 35625; UCB-35625; UCB35625; 2,7-dichloro-N-[1-(cycloocten-1-ylmethyl)-1-ethylpiperidin-1-ium-4-yl]-9H-xanthene-9-carboxamide; iodide. CAS No. 353791-85-2. Molecular formula: C30H37Cl2IN2O2. Mole weight: 655.44. | |
| RS102895 | RS102895 is a potent CCR2 antagonist, with an IC 50 of 360 nM, and shows no effect on CCR1. Uses: Scientific research. Group: Signaling pathways. CAS No. 300815-41-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-18611A. | |
| RS102895 hydrochloride | RS102895 hydrochloride is a potent CCR2 antagonist, with an IC 50 of 360 nM, and shows no effect on CCR1. Uses: Scientific research. Group: Signaling pathways. CAS No. 1173022-16-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-18611. | |
| RS 102895 Hydrochloride (1-[2-[4- (Trifluoromethyl) phenyl]ethyl]-spiro[4H-3, 1-benzoxazine-4, 4-piperidin]-2 (1H) -one Hydrochloride, RS 102895, RS102895) | A selective antagonist for CCR2 receptors (IC50 = 0.36 and 17.8uM for CCR2b and CCR1 receptors, respectively). Blocks monocyte chemoattractant protein-1 induced calcium influx and chemotaxis (IC50 = 32nM and 1.7uM respectively). A potential anti-inflammatory therapeutic agent by Inhibiting alpha1A, alpha1D and 5-HT1A receptors. Group: Biochemicals. Grades: Highly Purified. CAS No. 300815-41-2. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| RS 504393 | RS 504393 is a selective CCR2 chemokine receptor antagonist ( IC 50 values are 89 nM and > 100 μM for inhibition of human recombinant CCR2 and CCR1 receptors respectively). Uses: Scientific research. Group: Signaling pathways. CAS No. 300816-15-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15418. | |
| tert-Butoxycarbonyl-D-valine | tert-Butoxycarbonyl-D-valine is used in the preparation of selective CCR1 antagonists in the treatment of rheumatoid arthritis. Also used in the preparation of antileishmanial agents. Group: Biochemicals. Alternative Names: (R)-2-(tert-Butoxycarbonylamino)-3-methylbutanoic Acid; (R)-2-(tert-Butoxycarbonylamino)-3-methylbutanoic Acid; N-Boc-D-valine; N-tert-Butoxycarbonyl-D-valine; N-tert-Butyloxycarbonyl-D-valine; NSC 334316. Grades: Highly Purified. CAS No. 22838-58-0. Pack Sizes: 10g. US Biological Life Sciences. | Worldwide |
| UCB 35625 | UCB 35625 is a potent CCR1 and CCR3 antagonist. Synonyms: UCB35625, UCB 35625, UCB-35625; 1,4-TRANS-1-(1-CYCLOOCTEN-1-YLMETHYL)-4-[[(2,7-DICHLORO-9H-XANTHEN-9-YL)CARBONYL]AMINO]-1-ETHYLPIPERIDINIUM IODIDE. CAS No. 301648-08-8. Molecular formula: C30H37Cl2IN2O2. Mole weight: 655.44. | |
| Vercirnon | Vercirnon (GSK1605786A) is an orally bioavailable, selective, and potent antagonist of CCR9. Vercirnon inhibits CCR9-mediated Ca2+ mobilization and chemotaxis on Molt-4 cells with IC50 values of 5.4 and 3.4 nM, respectively. Vercirnon is selective for CCR9 over CCR1-12 and CX3CR1-7 (IC50s>10 ?M for all). Vercirnon is an equipotent inhibitor of CCL25-directed chemotaxis of both splice forms of CCR9 (CCR9A and CCR9B) with IC50 values of 2.8 and 2.6 nM, respectively[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GSK-1605786; CCX282-B; Traficet-EN. CAS No. 698394-73-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15724. | |
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