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Ammonium chloride, for cell culture (Salmiac, for cell culture) is a reagent that can be used in cell culture to provide a source of nitrogen. Ammonium chloride can be used as a heteropolar compound to regulate pH value, which can cause intracellular alkalination and metabolic acidosis, thus affecting the activity of enzymes and affecting the process of biological systems. Ammonium chloride acts as an autophagy inhibitor.Ammonium chloride is also a lysosome inhibitor. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: Salmiac, for cell culture. CAS No. 12125-02-9. Pack Sizes: 50 mg; 100 mg. Product ID: HY-Y1269C.
Calcium chloride anhydrous, for cell culture
Calcium chloride anhydrous, for cell culture is an inorganic salt for the preparation of various buffers [1]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: Calcium dichloride anhydrous, for cell culture. CAS No. 10043-52-4. Pack Sizes: 50 mg. Product ID: HY-Y0406E.
Calcium chloride dihydrate, for cell culture, 99%
Calcium chloride dihydrate, for cell culture, 99% is a biochemical reagent. Calcium chloride dihydrate, for cell culture, 99% enhances the dentinogenic differentiation potential of WMTA on cells. Calcium chloride dihydrate, for cell culture, 99% can be used as a biological material or organic compound for life science related research[1][2. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 10035-04-8. Pack Sizes: 25 g. Product ID: HY-108536D.
Cefotaxime, Sodium Salt, High Purity, Cell Culture-Tested
Potent beta-lactamase-resistant antibiotic of cephalosporin class. Active against Gram-positive and Gram-negative organisms, including Gram-negative anaerobes. Inhibits cell wall synthesis. Group: Biochemicals. Alternative Names: (6R, 7R) -3-[ (Acetyloxy) methyl]-7-[[ (2Z) -2- (2-amino-4-thiazolyl) -2- (methoxyimino) acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4. 2. 0]oct-2-ene-2-carboxylic Acid Sodium Salt; Cefotax; HR 756; Pretor; Tolycar. Grades: Cell Culture Grade. CAS No. 64485-93-4. Pack Sizes: 1g, 5g. US Biological Life Sciences.
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Collagen Type IV from human cell culture
Bornstein and Traub Type IV, 0.3 mg/mL, sterile-filtered, BioReagent, suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
D-(+)-Glucose anhydrous cell culture tested
1kg Pack Size. Group: Carbohydrates, Sugars. Formula: C6H12O6. CAS No. 50-99-7. Prepack ID 58499289-1kg. Molecular Weight 180.16. See USA prepack pricing.
D-(+)-Glucose anhydrous cell culture tested
500g Pack Size. Group: Carbohydrates, Sugars. Formula: C6H12O6. CAS No. 50-99-7. Prepack ID 58499289-500g. Molecular Weight 180.16. See USA prepack pricing.
Dimethylsulfoxide (DMSO) for Cell Culture
Ready-to-use sterile filtered product conveniently packaged in septum screw-capped amber bottles. Meets ACS testing requirements.In cryobiology DMSO has been used as a cryoprotectant and is still an important constituent of cryoprotectant vitrification mixtures used to preserve organs, tissues, and cell suspensions. Without it, up to 90% of frozen cells will become inactive. It is particularly important in the freezing and long-term storage of embryonic stem cells and hematopoietic stem cells, which are often frozen in a mixture of 10% DMSO, a freezing medium, and 30% fetal bovine serum. In the cryogenic freezing of heteroploid cell lines (MDCK, VERO, etc.) a mixture of 10% DMSO with 90% EMEM (70% EMEM + 30% fetal bovine serum + antibiotic mixture) is used. Group: Biochemicals. Alternative Names: Methyl Sulfoxide; Dimethylsulfoxide; DMSO. Grades: Cell Culture Grade. CAS No. 67-68-5. Pack Sizes: 5x5ml, 5x10ml, 25ml, 50ml, 100ml. Molecular Formula: C2H6SO, Molecular Weight: 78.13. US Biological Life Sciences.
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D-Sorbitol, for cell culture
D-Sorbitol, for cell culture (D-Glucitol, for cell culture) is a biochemical reagent that can be used as a biological material or organic compound for life science related research [1]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: D-Glucitol, for cell culture. CAS No. 50-70-4. Pack Sizes: 25 g. Product ID: HY-B0400B.
D-(+)-Sucrose, plant cell culture tested
100g Pack Size. Group: Analytical Reagents, Biochemicals, Carbohydrates, Diagnostic Raw Materials. Formula: C12H22O11. CAS No. 57-50-1. Prepack ID 41080463-100g. Molecular Weight 342.3. See USA prepack pricing.
D-(+)-Sucrose, plant cell culture tested
500g Pack Size. Group: Analytical Reagents, Biochemicals, Carbohydrates, Diagnostic Raw Materials. Formula: C12H22O11. CAS No. 57-50-1. Prepack ID 41080463-500g. Molecular Weight 342.3. See USA prepack pricing.
Gellan gum, for cell culture
Gellan gum is a linear microbial exopolysaccharide that can be used as a cell scaffold for both soft tissue and load bearing applications. Gellan gum has many advantages such as biocompatibility, biodegradability, nontoxic in nature, and physical stability in the presence of cations [1] [2]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: Agar substitute gelling agent, for cell culture. CAS No. 71010-52-1. Pack Sizes: 100 mg. Product ID: HY-125870.
Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg)
Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) (HSA) is the most abundant protein in plasma and is a major determinant of plasma oncotic pressure. Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) exhibits antioxidant, anticoagulant, anti-inflammatory, anti-platelet aggregation activities as well as colloid osmotic action. Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) can block the inhibitory effect of GML on human T cells, providing protective function for T cells. Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) is also associated with cardiovascular diseases and can partially prevent the LPS (HY-D1056) induced oxidative stress, as well as the upregulation of NF-?B, iNOS, and peroxynitrite (ONOO?) in the vascular wall, contributing to the reduction of blood pressure[1][2][3]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: HSA (Cell culture grade, Endotoxin<0.125 EU/mg). CAS No. 70024-90-7. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-P1956A.
Iron(II) sulfate heptahydrate, for cell culture, 99%
Iron(II) sulfate heptahydrate, for cell culture, 99% is a biochemical reagent that can be used as a biological material or organic compound for life science related research [1]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: Ferrous sulfate heptahydrate, for cell culture, 99%. CAS No. 7782-63-0. Pack Sizes: 25 g. Product ID: HY-Y1103A.
L-Arginine hydrochloride, Cell Culture Grade
500g Pack Size. Group: Amino Acids, Biochemicals, Building Blocks, Peptide Reagents. Formula: C6H14N4O2 · HCl. CAS No. 1119-34-2. Prepack ID 90027624-500g. Molecular Weight 210.66. See USA prepack pricing.
L-Ascorbic acid, cell culture
L-Ascorbic Acid protects cells against the damaging effects of radiation and oxygen radicals. L-Ascorbic Acid increases the rate of mineralization in osteoblasts. L-Ascorbic Acid is involved in hydroxylation of proline and lysine. L-Ascorbic Acid reduces Na+/Ca2+ exchange in cultured astrocytes. L-Ascorbic Acid modulates cyclic nucleotide levels in B and T cells inhibits apoptosis in cultured rat ovarian follicles. L-Ascorbic Acid, Free Acid is an inhibitor of T-type Ca++ CP α 1H. Applications: A calcium channel protein inhibitor. Group: Coenzymes. Synonyms: Vitamin C; L-Threoascorbic acid; Antiscorbutic factor. CAS No. 50-81-7. Mole weight: 176.12. Appearance: Powder. Form: Solid. Vitamin C; L-Threoascorbic acid; Antiscorbutic factor; L-Ascorbic acid, cell culture; 50-81-7. Cat No: COEC-103.
Potassium chloride, for cell culture
Potassium chloride, for cell culture is potassium chloride that can be used for cell culture. Potassium chloride, for cell culture increases extracellular potassium ion concentration to induce cellular depolarization, thereby activating voltage-gated calcium channels and regulating intracellular calcium signaling. Potassium chloride, for cell culture upregulates Brn-5. Potassium chloride, for cell culture inhibits the proliferation of neurons and some plant cells[1][2]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 7447-40-7. Pack Sizes: 250 g; 500 g. Product ID: HY-Y0537E.
Potassium Iodide 99+% Cell Culture Grade
Potassium Iodide is used primarily used in the treatment of radiation poisoning due to environmental contamination by iodine-131. Group: Biochemicals. Alternative Names: Antistrumin; Asmofug E; Ceoiodin; Iod-active; Iodomarin; Iodostin; Jodid; K1-N; KaiodKalium iodidum; Knollide; NSC 77362; Pherajod; Potassium iodide; Potassium monoiodide; Thyro-Block; Thyrojod; Zeoiodine. Grades: Cell Culture Grade. CAS No. 7681-11-0. Pack Sizes: 100g, 500g, 1Kg, 2.5Kg. Molecular Formula: KI. US Biological Life Sciences.
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Spermidine free base cell culture tested
5g Pack Size. Group: Amines, Biochemicals, Organics, Research Organics & Inorganics. Formula: C7H19N3. CAS No. 124-20-9. Prepack ID 13986831-5g. Molecular Weight 145.25. See USA prepack pricing.
trans-4-Hydroxy-L-proline suitable for cell culture
Trans-4-hydroxy-L-proline is an isomer of hydroxyproline used as a chiral building block in the production of many pharmaceuticals like neuroexcitatory kainoids. Uses: Peptide synthesis. Additional or Alternative Names: 4-Hydroxyproline, Hydroxyproline, (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid, Hyp. Product Category: Amino Acids. CAS No. 51-35-4. Mole weight: 131.13. Canonical SMILES: O[C@H]1CN[C@@H](C1)C(O)=O. ECNumber: 200-091-9. Product ID: ACM51354-3. Alfa Chemistry ISO 9001:2015 Certified.
1,11-Undecanedicarboxylic Acid
1,11-Undecanedicarboxylic Acid is used in the synthesis of two Bis (tetra hydroisoquinoline) which were highly cytotoxic for cancer-cell cultures and less toxic to healthy cells and exhibited noticeable antimicrobial activity against Gram-positive and Gram-negative bacteria and fungal strain Candida albicans. Group: Biochemicals. Grades: Highly Purified. CAS No. 505-52-2. Pack Sizes: 2.5g, 5g. Molecular Formula: C13H24O4, Molecular Weight: 244.33. US Biological Life Sciences.
(11α,17 β)-11,17-dihydroxy-17-methylandrost-4-en-3-one is a testosterone derivative. It is an adrenal steroid hormone with glucocorticoid activity causes increased zinc uptake in human cell cultures. Group: Biochemicals. Grades: Highly Purified. CAS No. 1807-02-9. Pack Sizes: 2.5mg, 25mg. Molecular Formula: C20H30O3, Molecular Weight: 318.45. US Biological Life Sciences.
(11α,17 β)-11,17-dihydroxy-17-methylandrost-4-en-3-one-d3 is a testosterone derivative. It is an adrenal steroid hormone with glucocorticoid activity causes increased zinc uptake in human cell cultures. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C20H27D3O3, Molecular Weight: 321.47. US Biological Life Sciences.
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1,2,3,6-Tetra-O-methyl-D-glucopyranoside
1,2,3,6-Tetra-O-methyl-D-glucopyranoside - a synthetic biochemical agent - is extensively employed in contemporary cell culture investigations as a non-metabolizable glucose analogue. Through cellular signaling observation, this agent permits a comprehensive evaluation of glucose transport in relation to metabolism, thereby advancing our insight on its dependence. Besides, owing to its saccharide structure, 1,2,3,6-Tetra-O-methyl-D-glucopyranoside represents an appropriate substrate for glycosidase enzyme assays - identifying and gauging the enzymes activities. Molecular formula: C10H20O6. Mole weight: 236.26.
14-3-3 Antagonist I, 2-5 ( (S) -2- (2- (4-Azidobenzamido) acetamido) -3- ( (4-hydroxyphenethyl) amino) -3-oxopropyl-dihydrogen Phosphate)
A cell-permeable dipeptidyl-phosphoserine compound that effectively disrupts 14-3-3 interaction with its ligands (IC50=2.6uM against TMR-GG-RLSHpSSLPG binding to human 14-3-3 sigma), including Raf-1 and p53. Shown to induce caspase-3 activation and apoptotic cell death in human lung adenocarcinoma A549 cultures (100uM) in a time-dependent manner. Group: Biochemicals. Grades: Purified. Pack Sizes: 5mg. Molecular Formula: C??H??N?O?P, Molecular Weight: 506.4. US Biological Life Sciences.
(17α)-Estra-1,3,5(10)-triene-3,17-diol 4-Methyl 3-Benzoate 17-(4-Nitrobenzoate) is an intermediate in the synthesis of 4-Methyl-17α-Estradiol wich is a related compound of 17 α-Estradiol (E887995), a biologically active estrogen in human breast cancer cells in tissue culture. 17-?stradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimers disease and ischemic stroke. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 10mg. Molecular Formula: C33H33NO6. US Biological Life Sciences.
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17α-Estradiol
Estradiol (known as α-Estradiol or 17 α-Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture. 17-?stradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimers disease and ischemic stroke. Group: Biochemicals. Alternative Names: (17α)-Estra-1,3,5(10)-triene-3,17-diol; 1,3,5-Estratriene-3,17α-diol; 13 β-Methyl-1,3,5(10)-gonatriene-3,17α-diol; 17-Epiestradiol; 17α-Oestradiol; 3,17-Dihydroxyestratriene; 3,17α-Dihydroxyoestra-1,3,5(10)-triene; Alfatradiol; Epiestrol; Estra-1,3,5(10)-triene-3,17α-diol; NSC 20293; α-Estradiol. Grades: Highly Purified. CAS No. 57-91-0. Pack Sizes: 250mg. US Biological Life Sciences.
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17α-Estradiol-16,16,17-d3
Labeled Estradiol. Estradiol (known as α-Estradiol or 17 α-Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture. 17-?stradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimers disease and ischemic stroke. Group: Biochemicals. Alternative Names: (17α)-Estra-1,3,5(10)-triene-3,17-diol-d3; 1,3,5-Estratriene-3,17α-diol-d3; 13 β-Methyl-1,3,5(10)-gonatriene-3,17α-diol-d3; 17-Epiestradiol-d3; 17α-Oestradiol-d3; 3,17-Dihydroxyestratriene-d3; 3,17α-Dihydroxyoestra-1,3,5(10)-triene-d3; Alfatradiol-d3; Epiestrol-d3; Estra-1,3,5(10)-triene-3,17α-diol-d3; NSC 20293-d3; α-Estradiol-d3. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
A cell-permeable benzylidine-thioxothiazolidinone compound that blocks the steroidogenesis of testosterone by directly inhibiting 17b-HSD3- (17b-hydroxysteroid dehydrogenase type 3) catalyzed, NADPH-dependent, reduction of delta4-dione C17 ketone in a delta4-dione- (4-androstene-3,17-dione) competitive, highly potent (IC50=0.6, 6.0, and 40nM, respectively, against momoset, human, and mouse 17b-HSD3 activity in testes homogenate), and selective manner, displaying no activity against 17b-HSD1 and 17b-HSD2 activity. Poor pharmacokinetic properties limit its use to culture treatments and cell-free assays only. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
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20-Carboxy arachidonic acid
20-Carboxy arachidonic acid (20-COOH-AA) is the major metabolite of 20-HETE that is produced in renal tubular epithelial, endothelial, and microvascular smooth muscle cell cultures. This ω-oxidation conversion can take place using purified alcohol dehydrogenases three and four or by microsomes containing recombinant human CYP4F3B. Synonyms: 20-carboxy AA; 20-COOH-AA; 5Z,8Z,11Z,14Z-Eicosatetraenedioic acid; Arachidonic acid-20-carboxylic acid. Grades: >98%. CAS No. 79551-84-1. Molecular formula: C20H30O4. Mole weight: 334.5.
2- [ [ (1, 1-Dimethylethyl) dimethylsilyl] oxy] -N- [2- [ [ (1, 1-dimethylethyl) dimethylsilyl] oxy] ethyl] -ethanamine is used in the synthesis of indenoisoquinolines, a class of noncamptothecin topoisomerase I inhibitors which displays significant cytotoxicity in human cancer cell cultures. Group: Biochemicals. Grades: Highly Purified. CAS No. 169527-49-5. Pack Sizes: 250mg, 1g. Molecular Formula: C16H39NO2Si2, Molecular Weight: 333.66. US Biological Life Sciences.
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2-[2-[2- (2-Azidoethoxy) ethoxy]ethoxy]ethanol
Applications in medical research, drug-release, nanotechnology, materials research and cell culture. In the study of ligand, polypeptide synthesis support, graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. Group: Biochemicals. Alternative Names: Azido-PEG4-OH; N3-PEG4-OH; 1-Azido-3,6,9-trioxaundecane-11-ol. Grades: Highly Purified. CAS No. 86770-67-4. Pack Sizes: 250mg, 500mg, 1g. Molecular Formula: C?H??N?O?, Molecular Weight: 219.24. US Biological Life Sciences.
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2,4,5-Trichlorophenoxyacetic Acid-d4
2,4,5-Trichlorophenoxyacetic Acid-d5 is an isotope labelled analog of 2,4,5-Trichlorophenoxyacetic Acid. It is suitable for plant cell culture tested. Post-emergence herbicide. Group: Biochemicals. Grades: Highly Purified. CAS No. 358731-37-0. Pack Sizes: 2.5mg, 25mg. Molecular Formula: C8HD4Cl3O3. US Biological Life Sciences.
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(2, 4, 6-Trichlorophenoxy) acetic Acid
(2, 4, 6-Trichlorophenoxy) acetic Acid is suitable for plant cell culture testing. Post-emergence herbicide. Group: Biochemicals. Grades: Highly Purified. CAS No. 575-89-3. Pack Sizes: 500mg, 1g. Molecular Formula: C8H5Cl3O3, Molecular Weight: 255.48. US Biological Life Sciences.
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(2, 4, 6-Trichlorophenoxy) acetic Acid-13C6
(2, 4, 6-Trichlorophenoxy) acetic Acid-13C6 is an isotopic analog of (2, 4, 6-Trichlorophenoxy) acetic Acid (T774580), suitable for plant cell culture testing. Post-emergence herbicide. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C213C6H5Cl3O3. US Biological Life Sciences.
Worldwide
2,4-Dichlorophenoxyacetic Acid 98+%
Used as a supplement in plant cell culture media. Herbicide. Used to increase latex output of old rubber trees. Group: Biochemicals. Grades: Reagent Grade. CAS No. 94-75-7. Pack Sizes: 100g, 250g, 1Kg, 5Kg. Molecular Formula: C?H?Cl?O?, Molecular Weight: 221.04. US Biological Life Sciences.
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2,4-Dihydroxybenzoic acid
2,4-Dihydroxybenzoic acid is a degradation product of cyaniding glycoside from tart cheeries in cell culture. Uses: Scientific research. Group: Natural products. CAS No. 89-86-1. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-W012575.
Anagrelide metabolite, the major metabolite in hematopoietic cell cultures. Group: Biochemicals. Alternative Names: 5,6-Dichloro-1,4-dihydro-2-quinazolinamine Hydrobromide; RL 603. Grades: Highly Purified. CAS No. 327602-34-6. Pack Sizes: 100mg. US Biological Life Sciences.
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2-Deoxyuridine
2-Deoxyuridine is known as a nucleoside analog, functioning as a vital precursor for DNA research and development. This compound finding widespread application in various cell culture systems. Its utilization extends to exploring replication fidelity, DNA research and development intricacies, and repair mechanisms. Synonyms: 1-beta-D-Ribofuranosyl-4(1H)-pyrimidinone; 1-(β-D-ribofuranosyl)-4-pyrimidinone; 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-4-one; 1-(beta-D-Ribofuranosyl)-1,4-dihydropyrimidine-4-one. Grades: ≥95%. CAS No. 21052-20-0. Molecular formula: C9H12N2O5. Mole weight: 228.20.
(2-Hydroxypropyl)-gamma-cyclodextrin
(2-Hydroxypropyl)-gamma-cyclodextrin is a water-soluble alkylated cyclodextrin derivative. It can help improve the solubility of the drug in oral preparations or preparations. (2-Hydroxypropyl)-gamma-cyclodextrin is used for the dissolution of macromolecules and cell culture applications. (2-Hydroxypropyl)-gamma-cyclodextrin has been used to study its inhibitory effect on complement products and the inflammation induced by cholesterol crystals (CC) in plasma samples. Synonyms: 2-hydroxypropyl Ethers γ-Cyclodextrin; HGC. CAS No. 128446-34-4. Molecular formula: C7H6FNO2. Mole weight: 155.13.
(2-Hydroxypropyl)-γ-cyclodextrin is used in sthe solubilization of macromolecules and in cell culture applications. Similar to β-Cyclodextrin (C987830), however can work with larger molecules. Group: Biochemicals. Grades: Purified. CAS No. 128446-34-4. Pack Sizes: 1g, 5g. Molecular Formula: N/A. US Biological Life Sciences.
A lysine methyltransferase EZH2 (KMT63) inhibitor. DZNep is a selective inhibitor of trimethylation of lysine 27 on histone H3 (H3K27me3) and lysine 20 on histone H4 (H4K20me3). DZNep treatment of cultured human AML cells induces increased expression of the cell-cycle regulators p21, p27, and FBXO32, leading to cell cycle arrest and apoptosis. Group: Biochemicals. Alternative Names: 5R-(4-amino-1H-imidazo[4, 5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1S, 2R-diol). Grades: Highly Purified. CAS No. 102052-95-9. Pack Sizes: 250ug, 1mg. US Biological Life Sciences.
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3-Indoleacetic acid-d7
3-Indoleacetic acid-d7 is the deuterium labeled 3-Indoleacetic acid (HY-18569). 3-Indoleacetic acid (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. It can be added to cell culture medium to induce plant cell elongation and division[1]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: Indole-3-acetic acid-d7; 3-IAA-d7. CAS No. 1173020-21-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-18569S3.
3-MATIDA
3-MATIDA is a potent metabotropic glutamate (mGlu1) receptor antagonist with IC50 value of 6.3 μM at rat mGlu1a. It displays ≥ 40-fold selectivity over other receptors. It has neuroprotective activity in cultured murine cortical cells and rat hippocampal slice cultures in vitro. It reduces the volume of ischemia-induced brain infarcts in rats following systemic administration in vivo. Synonyms: α-Amino-5-carboxy-3-methyl-2-thiopheneaceticacid; 5-[amino(carboxy)methyl]-4-methylthiophene-2-carboxylic acid; 3-Methyl-aminothiophene dicarboxylic acid. Grades: ≥99% by HPLC. CAS No. 518357-51-2. Molecular formula: C8H9NO4S. Mole weight: 215.23.
4-1BBL human
recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
4-1BB Receptor human
recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
4-Bromoflavone
An aryl hydrocarbon hydroxylase inducer. Used as a phase II detoxifying enzymes, quninone reductase and glutathione S-transferase in cell culture and in different tissues of rats. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5g. US Biological Life Sciences.
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5(6)-Carboxy-2',7'-dichlorofluorescein diacetate
5(6)-Carboxy-2',7'-dichlorofluorescein diacetate is a cell permeant fluorescent indicator. 5(6)-Carboxy-2',7'-dichlorofluorescein diacetate can be used to assess reactive oxygen species (ROS) generation within human neuronal-glial (HNG) cells in primary co-culture [1]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 127770-45-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-D1078.
5,7-Dichlorokynurenic acid
5,7-Dichlorokynurenic acid (5,7-DCKA) is a selective and competitive antagonist of the glycine site on NMDA receptor with a K B of 65 nM. 5,7-Dichlorokynurenic acid, a derivative of kynurenic acid, reduced NMDA-induced neuron injury in rat cortical cell cultures [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 5,7-DCKA. CAS No. 131123-76-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-100834.
5-Ethynyl-2-deoxyuridine
5-Ethynyl-2-deoxyuridine is a extensively used nucleoside analog used as a probe for DNA synthesis. However, 5-Ethynyl-2-deoxyuridine is a toxic anti-metabolite, which potentially causes DNA instabiliy, necrosis and cell-cycle arrest, therefore it is often used for short-term DNA synthesis in tissue culture and living organisms where prolonged cell survival is not required. Group: Biochemicals. Alternative Names: EdU; 2'-Deoxy-5-ethynyluridine. Grades: Highly Purified. CAS No. 61135-33-9. Pack Sizes: 10mg, 25mg, 50mg, 100mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences.
Worldwide
5-(N,N-Hexamethylene)-amiloride
5-(N,N-Hexamethylene)-amiloride derives from an amiloride and is a potent Na+/H+ exchanger inhibitor, which decreases the intracellular pH (pHi) and induces apoptosis in leukemic cells. It is also an inhibitor of the HIV-1 Vpu virus ion channel and inhibits mouse hepatitis virus (MHV) replication and human coronavirus 229E (HCoV229E) replication in cultured L929 cells with EC50s of 3.91 μM and 1.34 μM, respectively. Synonyms: Hexamethylene amiloride; HMA. Grades: 0.98. CAS No. 1428-95-1. Molecular formula: C12H18ClN7O. Mole weight: 311.77.
5-(N,N-Hexamethylene)-amiloride
5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) derives from an amiloride and is a potent Na + /H + exchanger inhibitor, which decreases the intracellular pH (pH i ) and induces apoptosis in leukemic cells. 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) is also an inhibitor of the HIV-1 Vpu virus ion channel and inhibits mouse hepatitis virus (MHV) replication and human coronavirus 229E (HCoV229E) replication in cultured L929 cells with EC 50 s of 3.91 μM and 1.34 μM, respectively [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Hexamethylene amiloride; HMA. CAS No. 1428-95-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-128067.
8-Cl-cAMP is a selective cAMP analogue preferring protein kinase A type I. 8-Cl-cAMP has already been in several clinical trials to identify its inhibitory effect of growth and differentiation in cultured cancer cell lines. Synonyms: 8- Chloroadenosine- 3', 5'- cyclic monophosphate, sodium salt. Grades: ≥ 99% by HPLC. CAS No. 124705-03-9. Molecular formula: C10H10ClN5O6P · Na. Mole weight: 385.6.
A431+ Pervanadate Lysate
Pervanadate is a protein tyrosine phosphatase inhibitor that is commonly used to increase tyrosine phosphorylation in cells. When cells are treated with pervanadate for 30 minutes they undergo significant tyrosine phosphorylation, as shown by western blotting using anti-Phosphotyrosine. Confluent cultures of A431 cells were serum starved overnight. Cells were then either left untreated or treated with pervanadate (1 mM) for 30 minutes at 37°C Cells were lysed in 1% SDS, 1.0mM sodium ortho-vanadate, 10mM Tris (pH 7.4) buffer. Protein concentration was determined using the BCA method (Pierce) before diluting to final concentration and buffer. Group: Biologicals. Grades: Lysate. Pack Sizes: 100ug. US Biological Life Sciences.
A cell-permeable furopyrimidine that acts as a potent, ATP-binding site-targeting, Ack1-selective inhibitor (IC50 = 22nM) and effectively prevents receptor-mediated Ack1 activation (by >90% in MEF & LAPC4 cultures; 16h 800nM), while exhibiting much reduced potency against Lyn, Lck, Abl1 and BTK (IC50 ≥346.7nM) and no inhibitory activity toward 25 other kinases. Shown to completely inhibit EGF-induced, but not androgen DHT- (dihydrotestosterone) stimulated, AR transcription activity in serum- and androgen-deprived prostate cancer LAPC4 cutlures. Effectively inhibits androgen-independent LNCaP prostate cancer growth both in vitro (by 60%; 72h 8uM) and in castrated mice in vivo (4mg/kg/96h injections on day 7/11/15/19/23/27 post tumor transplant). Group: Biochemicals. Grades: Highly Purified. CAS No. 873305-35-2. Pack Sizes: 10mg. US Biological Life Sciences.
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Actinomycin D (Dactinomycin)
Suitable for use in nucleic acid inhibition. Actinomycin D inhibits the proliferation of cells in a cell-cycle nonspecific way by forming a stable complex with DNA (via deoxyguanosine residues), thus inhibiting DNA-primed RNA synthesis. It is used in cell culture as a selection agent. Antibiotic. Antitumor compound. Cytotoxic. Apoptosis inducer. RNA synthesis inhibitor. DNA intercalating agent. Mcl-1 expression inhibitor. p53 pathway activator. Source:Streptomyces sp. Group: Biochemicals. Alternative Names: Streptomyces antibioticus; 2-Amino- (N, N) -1-bis (hexadeca hydro-6, 13-diisopropyl -2, 5, 9-tri methyl -1, 4, 7, 11, 14-pentaoxo-1H-pyrrolo [2, 1] - [1, 4, 7, 10, 13] oxatetra azacyclohexadecin-10-yl ) -4, 6-di methyl -3-oxo-3H-phenoxazine-1, 9-dicarboxamide ; Dactinomycin, Actinomycin IV, Actinomycin C1; Actactinomycin A IV; Actinomycin 7; Dilactone Actinomycindioic D Acid; Lyovac Cosmegen; Cosmogen; Meractinomycin. Grades: Cell Culture Grade. CAS No. 50-76-0. Pack Sizes: 5mg, 10mg, 25mg, 100mg, 500mg. Molecular Formula: C62H86N12O16, Molecular Weight: 1255.43. US Biological Life Sciences.
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Activin A human
?95% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, lyophilized powder, suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
Activin A human
recombinant, expressed in E. coli, ?97% (SDS-PAGE), ?97% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
Activin Receptor-Like Kinase 1/Fc Chimera from mouse
>95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
Activin Receptor-Like Kinase 1/Fc Chimera human
>90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
Activin Receptor-Like Kinase 7/Fc Chimera from rat
>90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
Adenine Free Base
Constituent of nucleic acids and coenzymes. Useful in cell culture media, dropout media for yeast selection. Widespread throughout animal and plant tissues combined with niacinamide, d-ribose, and phosphoric acids; a constituent of nucleic acids and coenzymes, such as codehydrase I and II, adenylic acid, coalaninedehydrase. It is used in microbial determination of niacin; in research on heredity, virus diseases, and cancer. Group: Biochemicals. Alternative Names: 6-Aminopurine. Grades: Molecular Biology Grade. CAS No. 73-24-5. Pack Sizes: 25g, 100g, 500g, 1Kg. Molecular Formula: C5H5N5, Molecular Weight: 135.13. US Biological Life Sciences.
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Adenine Sulfate (Hemisulfate), Dihydrate
Adenine Sulfate (Hemisulfate), Dihydrate. Group: Biochemicals. Alternative Names: 6-Aminopurine sulfate salt; Adenine hemisulphate salt. Grades: Cell Culture Grade. CAS No. 6509-19-9. Pack Sizes: 50g, 100g, 250g, 500g. Molecular Formula: (C5H6N5)2SO4 2H2O, Molecular Weight: 404.4. US Biological Life Sciences.
In the extracellular space, ecto-5?-nucleotidase (CD73) dephosphorylates adenosine triphosphate (ATP) to produce adenosine. Adenosine has four receptors namely A1R, A2AR A2BR and A3R. Adenosine plays a key role in the osteogenic differentiation. A1R induces osteoclast differentiation and A2AR induces osteoblast differentiation. Adenosine has been used: as a supplement in embryonic type culture medium for in vitro osteogenic differentiation for evaluation of its effect on cell survival by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT assay) and cell proliferation by 3H-thymidine incorporation assay in multi drug resistant glioblastoma stem-like cells (GSCs), and as a standard in high performance liquid chromatography (HPLC). as a constituent in collagenase solution for the collagenase digestion of mice fat tissue. Group: Biochemicals. Alternative Names: 9- β-D-Ribofuranosyl-9H-purin-6-amine; 9- β-D-Ribofuranosyladenine; Adenine Riboside; Adenocard; Adenocor; Adenogesic; Adenoscan; Adrekar; Boniton; D-Adenosine; 1-(6-Amino-9H-purin-9-yl)-1-deoxy- β-D-ribofuranose; Myocol; NSC 7652. Grades: Molecular Biology Grade. CAS No. 58-61-7. Pack Sizes: 100g, 500g. Molecular Formula: C10H13N5O4, Molecular Weight: 267.25. US Biological Life Sciences.
Orally-active adiponectin receptor (AdipoR) agonist. Binds to AdipoR1 and AdipoR2 at low um concentration. Activates 5'-adenosine monophosphate-activated protein kinase (AMPK) in cultured mammalian cells. Activates peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1alpha) which boosts mitochondrial proliferation and energy metabolism. Improves diabetes, glucose and lipid metabolism and insulin sensitivity in cultured cells and in mice by AdipoR-dependent mechanisms. Rescued the shortened lifespan of db/db mice (AdipoRs KO) on high-fat diet. Reduces expression levels of genes encoding inflammatory cytokines such as TNF-alpha, IL-6 and CCL-2 in WAT of WT mice but not db/db mice. Group: Biochemicals. Grades: Highly Purified. CAS No. 924416-43-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
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ADT-OH
ADT-OH is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor. ADT is a putative neuroprotectant and antioxidant that increases glutathione levels in cultured astroglial cells. ADT-OH was shown to reduce tPA-enhanced Akt activation and VEGF expression in brain microvascular endothelial cells. Synonyms: 5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione; Desmethylanethol trithione; 3H-1,2-Dithiole-3-thione, 5-(4-hydroxyphenyl)-. CAS No. 18274-81-2. Molecular formula: C9H6OS3. Mole weight: 226.326.
Roscovitine-related purine with no activity on CDKs (used as control for roscovitine). Selectively and potently increases production of extracellular Abeta42 and decreases production of extracellular Abeta38 in cultured cells. Extracellular Abeta40 levels remain stable. Intracellular levels of these amyloids appear to remain stable. Alzheimer's Disease (AD) accelerator that interacts with VDAC1, prohibitin and mitofilin, possibly interfering with subcellular compartmentalization and lipid rafts properties, shifting gamma-secretase activity toward Abeta42 generation. Induces a reversible mitochondrial phenotype reminiscent of the one observed in AD brains. Tool to detect inhibitors of Aftin-induced actions (potential anti-AD compounds). Binds pyridoxal kinase. Group: Biochemicals. Grades: Highly Purified. CAS No. 866893-90-5. Pack Sizes: 1mg, 5mg, 25mg. US Biological Life Sciences.
Roscovitine-related purine with no activity on CDKs (used as control for roscovitine). Selectively and potently increases production of extracellular Ab42 and decreases production of extracellular Ab38 in cultured cells. Extracellular Ab40 levels remain stable. Intracellular levels of these amyloids appear to remain stable. Alzheimer's Disease (AD) accelerator that interacts with VDAC1, prohibitin and mitofilin, possibly interfering with subcellular compartmentalization and lipid rafts properties, shifting gamma-secretase activity toward Ab42 generation. Induces a reversible mitochondrial phenotype reminiscent of the one observed in AD brains. Tool to detect inhibitors of Aftin-induced actions (potential anti-AD compounds). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 5mg, 25mg. US Biological Life Sciences.
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