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| Product | Description | |
|---|---|---|
| L-Arginine hydrochloride, Cell Culture Grade | 500g Pack Size. Group: Amino Acids, Biochemicals, Building Blocks, Peptide Reagents. Formula: C6H14N4O2 · HCl. CAS No. 1119-34-2. Prepack ID 90027624-500g. Molecular Weight 210.66. See USA prepack pricing. |  |
| Potassium Iodide 99+% Cell Culture Grade | Potassium Iodide is used primarily used in the treatment of radiation poisoning due to environmental contamination by iodine-131. Group: Biochemicals. Alternative Names: Antistrumin; Asmofug E; Ceoiodin; Iod-active; Iodomarin; Iodostin; Jodid; K1-N; KaiodKalium iodidum; Knollide; NSC 77362; Pherajod; Potassium iodide; Potassium monoiodide; Thyro-Block; Thyrojod; Zeoiodine. Grades: Cell Culture Grade. CAS No. 7681-11-0. Pack Sizes: 100g, 500g, 1Kg, 2.5Kg. Molecular Formula: KI. US Biological Life Sciences. |  Worldwide |
| 1,11-Undecanedicarboxylic Acid | 1,11-Undecanedicarboxylic Acid is used in the synthesis of two Bis (tetra hydroisoquinoline) which were highly cytotoxic for cancer-cell cultures and less toxic to healthy cells and exhibited noticeable antimicrobial activity against Gram-positive and Gram-negative bacteria and fungal strain Candida albicans. Group: Biochemicals. Grades: Highly Purified. CAS No. 505-52-2. Pack Sizes: 2.5g, 5g. Molecular Formula: C13H24O4, Molecular Weight: 244.33. US Biological Life Sciences. | Worldwide |
| (11α,17 β)-11,17-dihydroxy-17-methylandrost-4-en-3-one | (11α,17 β)-11,17-dihydroxy-17-methylandrost-4-en-3-one is a testosterone derivative. It is an adrenal steroid hormone with glucocorticoid activity causes increased zinc uptake in human cell cultures. Group: Biochemicals. Grades: Highly Purified. CAS No. 1807-02-9. Pack Sizes: 2.5mg, 25mg. Molecular Formula: C20H30O3, Molecular Weight: 318.45. US Biological Life Sciences. | Worldwide |
| (11α,17 β)-11,17-Dihydroxy-17-methylandrost-4-en-3-one-d3 | (11α,17 β)-11,17-dihydroxy-17-methylandrost-4-en-3-one-d3 is a testosterone derivative. It is an adrenal steroid hormone with glucocorticoid activity causes increased zinc uptake in human cell cultures. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C20H27D3O3, Molecular Weight: 321.47. US Biological Life Sciences. | Worldwide |
| 14-3-3 Antagonist I, 2-5 ( (S) -2- (2- (4-Azidobenzamido) acetamido) -3- ( (4-hydroxyphenethyl) amino) -3-oxopropyl-dihydrogen Phosphate) | A cell-permeable dipeptidyl-phosphoserine compound that effectively disrupts 14-3-3 interaction with its ligands (IC50=2.6uM against TMR-GG-RLSHpSSLPG binding to human 14-3-3 sigma), including Raf-1 and p53. Shown to induce caspase-3 activation and apoptotic cell death in human lung adenocarcinoma A549 cultures (100uM) in a time-dependent manner. Group: Biochemicals. Grades: Purified. Pack Sizes: 5mg. Molecular Formula: C??H??N?O?P, Molecular Weight: 506.4. US Biological Life Sciences. | Worldwide |
| (17α)-Estra-1,3,5(10)-triene-3,17-diol 4-Methyl 3-Benzoate 17-(4-Nitrobenzoate) | (17α)-Estra-1,3,5(10)-triene-3,17-diol 4-Methyl 3-Benzoate 17-(4-Nitrobenzoate) is an intermediate in the synthesis of 4-Methyl-17α-Estradiol wich is a related compound of 17 α-Estradiol (E887995), a biologically active estrogen in human breast cancer cells in tissue culture. 17-?stradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimers disease and ischemic stroke. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 10mg. Molecular Formula: C33H33NO6. US Biological Life Sciences. | Worldwide |
| 17α-Estradiol | Estradiol (known as α-Estradiol or 17 α-Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture. 17-?stradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimers disease and ischemic stroke. Group: Biochemicals. Alternative Names: (17α)-Estra-1,3,5(10)-triene-3,17-diol; 1,3,5-Estratriene-3,17α-diol; 13 β-Methyl-1,3,5(10)-gonatriene-3,17α-diol; 17-Epiestradiol; 17α-Oestradiol; 3,17-Dihydroxyestratriene; 3,17α-Dihydroxyoestra-1,3,5(10)-triene; Alfatradiol; Epiestrol; Estra-1,3,5(10)-triene-3,17α-diol; NSC 20293; α-Estradiol. Grades: Highly Purified. CAS No. 57-91-0. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
| 17α-Estradiol-16,16,17-d3 | Labeled Estradiol. Estradiol (known as α-Estradiol or 17 α-Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture. 17-?stradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimers disease and ischemic stroke. Group: Biochemicals. Alternative Names: (17α)-Estra-1,3,5(10)-triene-3,17-diol-d3; 1,3,5-Estratriene-3,17α-diol-d3; 13 β-Methyl-1,3,5(10)-gonatriene-3,17α-diol-d3; 17-Epiestradiol-d3; 17α-Oestradiol-d3; 3,17-Dihydroxyestratriene-d3; 3,17α-Dihydroxyoestra-1,3,5(10)-triene-d3; Alfatradiol-d3; Epiestrol-d3; Estra-1,3,5(10)-triene-3,17α-diol-d3; NSC 20293-d3; α-Estradiol-d3. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 17b-Hydroxysteroid Dehydrogenase Type-3 Inhibitor (17b-HSD3 Inhibitor, 5-(3-Bromo-4-hydroxybenzylidene)-3-(4-methoxyphenyl)-2-thioxothiazolidin-4-one) | A cell-permeable benzylidine-thioxothiazolidinone compound that blocks the steroidogenesis of testosterone by directly inhibiting 17b-HSD3- (17b-hydroxysteroid dehydrogenase type 3) catalyzed, NADPH-dependent, reduction of delta4-dione C17 ketone in a delta4-dione- (4-androstene-3,17-dione) competitive, highly potent (IC50=0.6, 6.0, and 40nM, respectively, against momoset, human, and mouse 17b-HSD3 activity in testes homogenate), and selective manner, displaying no activity against 17b-HSD1 and 17b-HSD2 activity. Poor pharmacokinetic properties limit its use to culture treatments and cell-free assays only. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 20-Carboxy arachidonic acid | 20-Carboxy arachidonic acid (20-COOH-AA) is the major metabolite of 20-HETE that is produced in renal tubular epithelial, endothelial, and microvascular smooth muscle cell cultures. This ω-oxidation conversion can take place using purified alcohol dehydrogenases three and four or by microsomes containing recombinant human CYP4F3B. Synonyms: 20-carboxy AA; 20-COOH-AA; 5Z,8Z,11Z,14Z-Eicosatetraenedioic acid; Arachidonic acid-20-carboxylic acid. Grades: >98%. CAS No. 79551-84-1. Molecular formula: C20H30O4. Mole weight: 334.5. |  |
| 2- [ [ (1, 1-Dimethylethyl) dimethylsilyl] oxy] -N- [2- [ [ (1, 1-dimethylethyl) dimethylsilyl] oxy] ethyl] -ethanamine | 2- [ [ (1, 1-Dimethylethyl) dimethylsilyl] oxy] -N- [2- [ [ (1, 1-dimethylethyl) dimethylsilyl] oxy] ethyl] -ethanamine is used in the synthesis of indenoisoquinolines, a class of noncamptothecin topoisomerase I inhibitors which displays significant cytotoxicity in human cancer cell cultures. Group: Biochemicals. Grades: Highly Purified. CAS No. 169527-49-5. Pack Sizes: 250mg, 1g. Molecular Formula: C16H39NO2Si2, Molecular Weight: 333.66. US Biological Life Sciences. | Worldwide |
| 2-[2-[2- (2-Azidoethoxy) ethoxy]ethoxy]ethanol | Applications in medical research, drug-release, nanotechnology, materials research and cell culture. In the study of ligand, polypeptide synthesis support, graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. Group: Biochemicals. Alternative Names: Azido-PEG4-OH; N3-PEG4-OH; 1-Azido-3,6,9-trioxaundecane-11-ol. Grades: Highly Purified. CAS No. 86770-67-4. Pack Sizes: 250mg, 500mg, 1g. Molecular Formula: C?H??N?O?, Molecular Weight: 219.24. US Biological Life Sciences. | Worldwide |
| 2,4,5-Trichlorophenoxyacetic Acid-d4 | 2,4,5-Trichlorophenoxyacetic Acid-d5 is an isotope labelled analog of 2,4,5-Trichlorophenoxyacetic Acid. It is suitable for plant cell culture tested. Post-emergence herbicide. Group: Biochemicals. Grades: Highly Purified. CAS No. 358731-37-0. Pack Sizes: 2.5mg, 25mg. Molecular Formula: C8HD4Cl3O3. US Biological Life Sciences. | Worldwide |
| (2, 4, 6-Trichlorophenoxy) acetic Acid | (2, 4, 6-Trichlorophenoxy) acetic Acid is suitable for plant cell culture testing. Post-emergence herbicide. Group: Biochemicals. Grades: Highly Purified. CAS No. 575-89-3. Pack Sizes: 500mg, 1g. Molecular Formula: C8H5Cl3O3, Molecular Weight: 255.48. US Biological Life Sciences. | Worldwide |
| (2, 4, 6-Trichlorophenoxy) acetic Acid-13C6 | (2, 4, 6-Trichlorophenoxy) acetic Acid-13C6 is an isotopic analog of (2, 4, 6-Trichlorophenoxy) acetic Acid (T774580), suitable for plant cell culture testing. Post-emergence herbicide. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C213C6H5Cl3O3. US Biological Life Sciences. | Worldwide |
| 2,4-Dichlorophenoxyacetic Acid 98+% | Used as a supplement in plant cell culture media. Herbicide. Used to increase latex output of old rubber trees. Group: Biochemicals. Grades: Reagent Grade. CAS No. 94-75-7. Pack Sizes: 100g, 250g, 1Kg, 5Kg. Molecular Formula: C?H?Cl?O?, Molecular Weight: 221.04. US Biological Life Sciences. | Worldwide |
| 2-Amino-5,6-dichloro-3,4-dihydroquinazoline Hydrobromide | Anagrelide metabolite, the major metabolite in hematopoietic cell cultures. Group: Biochemicals. Alternative Names: 5,6-Dichloro-1,4-dihydro-2-quinazolinamine Hydrobromide; RL 603. Grades: Highly Purified. CAS No. 327602-34-6. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| 2-Deoxyuridine | 2-Deoxyuridine is known as a nucleoside analog, functioning as a vital precursor for DNA research and development. This compound finding widespread application in various cell culture systems. Its utilization extends to exploring replication fidelity, DNA research and development intricacies, and repair mechanisms. Synonyms: 1-beta-D-Ribofuranosyl-4(1H)-pyrimidinone; 1-(β-D-ribofuranosyl)-4-pyrimidinone; 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-4-one; 1-(beta-D-Ribofuranosyl)-1,4-dihydropyrimidine-4-one. Grades: ≥95%. CAS No. 21052-20-0. Molecular formula: C9H12N2O5. Mole weight: 228.20. | |
| (2-Hydroxypropyl)-γ-cyclodextrin (Technical Grade) | (2-Hydroxypropyl)-γ-cyclodextrin is used in sthe solubilization of macromolecules and in cell culture applications. Similar to β-Cyclodextrin (C987830), however can work with larger molecules. Group: Biochemicals. Grades: Purified. CAS No. 128446-34-4. Pack Sizes: 1g, 5g. Molecular Formula: N/A. US Biological Life Sciences. | Worldwide |
| 2-Ketoglutaric Acid (alpha Ketoglutaric Acid) | 2-Ketoglutaric Acid (alpha Ketoglutaric Acid). Group: Biochemicals. Alternative Names: 2-Oxopentanedioic Acid; 2-Oxo-1,5-pentanedioic Acid; 2-Oxoglutaric Acid; 2-Oxopentanedioic Acid; NSC 17391; α-Ketoglutaric Acid; α-Oxoglutaric Acid; α-Oxopentanedioic Acid; α-keto-Glutaric Acid. Grades: Cell Culture Grade. CAS No. 328-50-7. Pack Sizes: 100g, 500g, 1Kg, 5Kg. Molecular Formula: C5H6O5, Molecular Weight: 146.1. US Biological Life Sciences. | Worldwide |
| 3-Deazaneplanocin A (DZNep, NSC 617989) | A lysine methyltransferase EZH2 (KMT63) inhibitor. DZNep is a selective inhibitor of trimethylation of lysine 27 on histone H3 (H3K27me3) and lysine 20 on histone H4 (H4K20me3). DZNep treatment of cultured human AML cells induces increased expression of the cell-cycle regulators p21, p27, and FBXO32, leading to cell cycle arrest and apoptosis. Group: Biochemicals. Alternative Names: 5R-(4-amino-1H-imidazo[4, 5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1S, 2R-diol). Grades: Highly Purified. CAS No. 102052-95-9. Pack Sizes: 250ug, 1mg. US Biological Life Sciences. | Worldwide |
| 3-MATIDA | 3-MATIDA is a potent metabotropic glutamate (mGlu1) receptor antagonist with IC50 value of 6.3 μM at rat mGlu1a. It displays ≥ 40-fold selectivity over other receptors. It has neuroprotective activity in cultured murine cortical cells and rat hippocampal slice cultures in vitro. It reduces the volume of ischemia-induced brain infarcts in rats following systemic administration in vivo. Synonyms: α-Amino-5-carboxy-3-methyl-2-thiopheneaceticacid; 5-[amino(carboxy)methyl]-4-methylthiophene-2-carboxylic acid; 3-Methyl-aminothiophene dicarboxylic acid. Grades: ≥99% by HPLC. CAS No. 518357-51-2. Molecular formula: C8H9NO4S. Mole weight: 215.23. | |
| 4-Bromoflavone | An aryl hydrocarbon hydroxylase inducer. Used as a phase II detoxifying enzymes, quninone reductase and glutathione S-transferase in cell culture and in different tissues of rats. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5g. US Biological Life Sciences. | Worldwide |
| 5-Ethynyl-2-deoxyuridine | 5-Ethynyl-2-deoxyuridine is a extensively used nucleoside analog used as a probe for DNA synthesis. However, 5-Ethynyl-2-deoxyuridine is a toxic anti-metabolite, which potentially causes DNA instabiliy, necrosis and cell-cycle arrest, therefore it is often used for short-term DNA synthesis in tissue culture and living organisms where prolonged cell survival is not required. Group: Biochemicals. Alternative Names: EdU; 2'-Deoxy-5-ethynyluridine. Grades: Highly Purified. CAS No. 61135-33-9. Pack Sizes: 10mg, 25mg, 50mg, 100mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences. | Worldwide |
| 5-(N,N-Hexamethylene)-amiloride | 5-(N,N-Hexamethylene)-amiloride derives from an amiloride and is a potent Na+/H+ exchanger inhibitor, which decreases the intracellular pH (pHi) and induces apoptosis in leukemic cells. It is also an inhibitor of the HIV-1 Vpu virus ion channel and inhibits mouse hepatitis virus (MHV) replication and human coronavirus 229E (HCoV229E) replication in cultured L929 cells with EC50s of 3.91 μM and 1.34 μM, respectively. Synonyms: Hexamethylene amiloride; HMA. Grades: 0.98. CAS No. 1428-95-1. Molecular formula: C12H18ClN7O. Mole weight: 311.77. | |
| 6-[(E)-4-Hydroxy-3-methylbut-2-enylamino]-9-β-D-ribofuranosylpurine | A well-known, highly active stimulant of cell divisions in plant tissue cultures. Uses: Plant growth regulators. Synonyms: Adenosine, N-[(2E)-4-hydroxy-3-methyl-2-buten-1-yl]-; Adenosine, N-(4-hydroxy-3-methyl-2-butenyl)-, (E)-; Adenosine, N-[(2E)-4-hydroxy-3-methyl-2-butenyl]-; N-[(2E)-4-Hydroxy-3-methyl-2-buten-1-yl]adenosine; Zeatin riboside; 6-(4-Hydroxy-3-methyl-trans-2-butenylamino)-9-β-D-ribofuranosylpurine; 9-Ribosyl-trans-zeatin; 9-β-D-Ribofuranosylzeatin; MB 804; N6-(4-Hydroxy-3-methylbut-2-trans-enyl)adenosine; N6-(trans-4-Hydroxy-3-methylbut-2-enyl)adenosine; Ribosyl-trans-zeatin; Ribosylzeatin; trans-Zeatin 9-riboside; trans-Zeatin riboside; Zeatin 9-riboside; Zeatin 9-β-ribonucleoside; Zeatin ribonucleoside; Zeatin-9-β-D-ribofuranoside. Grades: 98%. CAS No. 6025-53-2. Molecular formula: C15H21N5O5. Mole weight: 351.36. | |
| 8-Cl-cAMP | 8-Cl-cAMP is a selective cAMP analogue preferring protein kinase A type I. 8-Cl-cAMP has already been in several clinical trials to identify its inhibitory effect of growth and differentiation in cultured cancer cell lines. Synonyms: 8- Chloroadenosine- 3', 5'- cyclic monophosphate, sodium salt. Grades: ≥ 99% by HPLC. CAS No. 124705-03-9. Molecular formula: C10H10ClN5O6P · Na. Mole weight: 385.6. | |
| A431+ Pervanadate Lysate | Pervanadate is a protein tyrosine phosphatase inhibitor that is commonly used to increase tyrosine phosphorylation in cells. When cells are treated with pervanadate for 30 minutes they undergo significant tyrosine phosphorylation, as shown by western blotting using anti-Phosphotyrosine. Confluent cultures of A431 cells were serum starved overnight. Cells were then either left untreated or treated with pervanadate (1 mM) for 30 minutes at 37°C Cells were lysed in 1% SDS, 1.0mM sodium ortho-vanadate, 10mM Tris (pH 7.4) buffer. Protein concentration was determined using the BCA method (Pierce) before diluting to final concentration and buffer. Group: Biologicals. Grades: Lysate. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| Ack1 Inhibitor, AIM-100 (Activated Cdc42 Kinase 1 Inhibitor, (S)-5,6-Diphenyl-N-((tetrahydrofuran-2-yl)methyl)furo[2,3-d]pyrimidin-4-amine) | A cell-permeable furopyrimidine that acts as a potent, ATP-binding site-targeting, Ack1-selective inhibitor (IC50 = 22nM) and effectively prevents receptor-mediated Ack1 activation (by >90% in MEF & LAPC4 cultures; 16h 800nM), while exhibiting much reduced potency against Lyn, Lck, Abl1 and BTK (IC50 ≥346.7nM) and no inhibitory activity toward 25 other kinases. Shown to completely inhibit EGF-induced, but not androgen DHT- (dihydrotestosterone) stimulated, AR transcription activity in serum- and androgen-deprived prostate cancer LAPC4 cutlures. Effectively inhibits androgen-independent LNCaP prostate cancer growth both in vitro (by 60%; 72h 8uM) and in castrated mice in vivo (4mg/kg/96h injections on day 7/11/15/19/23/27 post tumor transplant). Group: Biochemicals. Grades: Highly Purified. CAS No. 873305-35-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Actinomycin D (Dactinomycin) | Suitable for use in nucleic acid inhibition. Actinomycin D inhibits the proliferation of cells in a cell-cycle nonspecific way by forming a stable complex with DNA (via deoxyguanosine residues), thus inhibiting DNA-primed RNA synthesis. It is used in cell culture as a selection agent. Antibiotic. Antitumor compound. Cytotoxic. Apoptosis inducer. RNA synthesis inhibitor. DNA intercalating agent. Mcl-1 expression inhibitor. p53 pathway activator. Source:Streptomyces sp. Group: Biochemicals. Alternative Names: Streptomyces antibioticus; 2-Amino- (N, N) -1-bis (hexadeca hydro-6, 13-diisopropyl -2, 5, 9-tri methyl -1, 4, 7, 11, 14-pentaoxo-1H-pyrrolo [2, 1] - [1, 4, 7, 10, 13] oxatetra azacyclohexadecin-10-yl ) -4, 6-di methyl -3-oxo-3H-phenoxazine-1, 9-dicarboxamide ; Dactinomycin, Actinomycin IV, Actinomycin C1; Actactinomycin A IV; Actinomycin 7; Dilactone Actinomycindioic D Acid; Lyovac Cosmegen; Cosmogen; Meractinomycin. Grades: Cell Culture Grade. CAS No. 50-76-0. Pack Sizes: 5mg, 10mg, 25mg, 100mg, 500mg. Molecular Formula: C62H86N12O16, Molecular Weight: 1255.43. US Biological Life Sciences. | Worldwide |
| Adenine Free Base | Constituent of nucleic acids and coenzymes. Useful in cell culture media, dropout media for yeast selection. Widespread throughout animal and plant tissues combined with niacinamide, d-ribose, and phosphoric acids; a constituent of nucleic acids and coenzymes, such as codehydrase I and II, adenylic acid, coalaninedehydrase. It is used in microbial determination of niacin; in research on heredity, virus diseases, and cancer. Group: Biochemicals. Alternative Names: 6-Aminopurine. Grades: Molecular Biology Grade. CAS No. 73-24-5. Pack Sizes: 25g, 100g, 500g, 1Kg. Molecular Formula: C5H5N5, Molecular Weight: 135.13. US Biological Life Sciences. | Worldwide |
| Adenine Sulfate (Hemisulfate), Dihydrate | Adenine Sulfate (Hemisulfate), Dihydrate. Group: Biochemicals. Alternative Names: 6-Aminopurine sulfate salt; Adenine hemisulphate salt. Grades: Cell Culture Grade. CAS No. 6509-19-9. Pack Sizes: 50g, 100g, 250g, 500g. Molecular Formula: (C5H6N5)2SO4 2H2O, Molecular Weight: 404.4. US Biological Life Sciences. | Worldwide |
| Adenosine (9- β-D-ribofuranosyladenine, Adenine riboside, Adenine-9- β-D-ribofuranoside) | In the extracellular space, ecto-5?-nucleotidase (CD73) dephosphorylates adenosine triphosphate (ATP) to produce adenosine. Adenosine has four receptors namely A1R, A2AR A2BR and A3R. Adenosine plays a key role in the osteogenic differentiation. A1R induces osteoclast differentiation and A2AR induces osteoblast differentiation. Adenosine has been used: as a supplement in embryonic type culture medium for in vitro osteogenic differentiation for evaluation of its effect on cell survival by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT assay) and cell proliferation by 3H-thymidine incorporation assay in multi drug resistant glioblastoma stem-like cells (GSCs), and as a standard in high performance liquid chromatography (HPLC). as a constituent in collagenase solution for the collagenase digestion of mice fat tissue. Group: Biochemicals. Alternative Names: 9- β-D-Ribofuranosyl-9H-purin-6-amine; 9- β-D-Ribofuranosyladenine; Adenine Riboside; Adenocard; Adenocor; Adenogesic; Adenoscan; Adrekar; Boniton; D-Adenosine; 1-(6-Amino-9H-purin-9-yl)-1-deoxy- β-D-ribofuranose; Myocol; NSC 7652. Grades: Molecular Biology Grade. CAS No. 58-61-7. Pack Sizes: 100g, 500g. Molecular Formula: C10H13N5O4, Molecular Weight: 267.25. US Biological Life Sciences. | Worldwide |
| AdipoRon (2-(4-Benzoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide) | Orally-active adiponectin receptor (AdipoR) agonist. Binds to AdipoR1 and AdipoR2 at low um concentration. Activates 5'-adenosine monophosphate-activated protein kinase (AMPK) in cultured mammalian cells. Activates peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1alpha) which boosts mitochondrial proliferation and energy metabolism. Improves diabetes, glucose and lipid metabolism and insulin sensitivity in cultured cells and in mice by AdipoR-dependent mechanisms. Rescued the shortened lifespan of db/db mice (AdipoRs KO) on high-fat diet. Reduces expression levels of genes encoding inflammatory cytokines such as TNF-alpha, IL-6 and CCL-2 in WAT of WT mice but not db/db mice. Group: Biochemicals. Grades: Highly Purified. CAS No. 924416-43-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Aftin-4 (N6-Methyl-(R)-roscovitine, Amyloid-beta Forty-Two Inducer 4) | Roscovitine-related purine with no activity on CDKs (used as control for roscovitine). Selectively and potently increases production of extracellular Abeta42 and decreases production of extracellular Abeta38 in cultured cells. Extracellular Abeta40 levels remain stable. Intracellular levels of these amyloids appear to remain stable. Alzheimer's Disease (AD) accelerator that interacts with VDAC1, prohibitin and mitofilin, possibly interfering with subcellular compartmentalization and lipid rafts properties, shifting gamma-secretase activity toward Abeta42 generation. Induces a reversible mitochondrial phenotype reminiscent of the one observed in AD brains. Tool to detect inhibitors of Aftin-induced actions (potential anti-AD compounds). Binds pyridoxal kinase. Group: Biochemicals. Grades: Highly Purified. CAS No. 866893-90-5. Pack Sizes: 1mg, 5mg, 25mg. US Biological Life Sciences. | Worldwide |
| Aftin-5 ((2R)-2-[[9-Isopropyl-6-(N-methylanilino)purin-2-yl]amino]butan-1-ol, Amyloidbeta Forty-Two Inducer 5) | Roscovitine-related purine with no activity on CDKs (used as control for roscovitine). Selectively and potently increases production of extracellular Ab42 and decreases production of extracellular Ab38 in cultured cells. Extracellular Ab40 levels remain stable. Intracellular levels of these amyloids appear to remain stable. Alzheimer's Disease (AD) accelerator that interacts with VDAC1, prohibitin and mitofilin, possibly interfering with subcellular compartmentalization and lipid rafts properties, shifting gamma-secretase activity toward Ab42 generation. Induces a reversible mitochondrial phenotype reminiscent of the one observed in AD brains. Tool to detect inhibitors of Aftin-induced actions (potential anti-AD compounds). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 5mg, 25mg. US Biological Life Sciences. | Worldwide |
| AGN 194310 | A high affinity pan-RAR antagonist (AGN194310, K(d) for binding to RARs = 2-5 nM) inhibited colony formation (by 50%) by all three lines at 16-34 nM, and led to a transient accumulation of flask-cultured cells in G1 followed by apoptosis. AGN194310 is 12-22 fold more potent than all-trans retinoic acid (ATRA) against cell lines and also more potent in inhibiting the growth of primary prostate carcinoma cells. The administration of all-trans retinoic acid to VAD mice resulted in a transient reduction in NF-kappaB activity and, conversely, a single dose of the RAR-pan-antagonist, AGN 194310, administered to control mice, led to a marked, transient induction of whole-body luminescence. Mice were treated with AGN194310, a synthetic retinoid that antagonises the physiological function of the three RAR isotypes (alpha, beta, gamma) but does not interact with RXRs. Analyses of the granulocytic lineage using Gr-1, c-Kit and CD11b antibodies, demonstrated that granulocyte numbers were strikingly increased across haemopoietic compartments in all AGN194310-treated mice. A significant increase in the frequency of progenitor cells containing granulocytes was observed in the bone marrow of mice following treatment with AGN194310. Synonyms: AGN194310; AGN-194310; VTP194310; VTP 194310; VTP-194310. Grades: >98%. CAS No. 229961-45-9. Molecular formula: C28H24O2S. Mole weight: 424.55. | |
| Akt Activator II, SC79 (Ethyl-2-amino-6-chloro-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate) | A cell-permeable and blood-brain barrier permeant HA14-1 analog that interacts with Akt PH domain PtdIns(3,4,5)P3- (PIP3) binding pocket, rendering Akt in a conformation susceptible to phosphorylation by upstream kinases. Shown to enhance both basal and receptor-mediated Akt phosphorylation (Thr308 and Ser473; 2 to 4ug/ml) with concomitant inhibition Akt membrane translocation in various cell cultures. Efficiently reduces glutamate-induced neurotoxicity both in primary neuron cultures (EC50 = 4ug/ml) in vitro and in a murine MCAO model (40mg/kg, i.p.) in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 305834-79-1. Pack Sizes: 25mg. Molecular Formula: C??H??ClN?O?. US Biological Life Sciences. | Worldwide |
| AKT inhibitor VIII | Akt Inhibitor VIII is a cell-permeable quinoxaline compound that has been shown to potently, selectively, allosterically, and reversibly inhibit Akt1, Akt2, and Akt3 activity. It does not exhibit any inhibitory effect against pleckstrin homology (PH) domain-lacking Akts, AGC family kinases, PKA, PKC or SGK. It also prevails over Akt1/Akt2-mediated resistance to chemotherapeutics in tumor cells and has been shown to block basal and stimulated phosphorylation/activation of Akt1/Akt2 in cultured cells and in mice. Synonyms: AKT inhibitor VIII; AKT-inhibitor-VIII; AKT inhibitor-8; AKT-inhibitor-8; Akt-I 1,2; Akti-1/2. Sigma-A6730. 2H-Benzimidazol-2-one, 1,3-dihydro-1-[1-[[4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl]methyl]-4-piperidinyl]-. Grades: >98%. CAS No. 612847-09-3. Molecular formula: C34H29N7O. Mole weight: 551.64. | |
| Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 (1,3-Dihydro-1-(1-((4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one, Akti-1/2) | A cell-permeable, reversible, potent, and selective inhibitor of Akt1/Akt2 activity (IC50=58nM, 210nM, and 2.12uM for Akt1, Akt2, and Akt3, respectively, in in vitro kinase assays). The inhibition is reported to be pleckstrin homology (PH) domain-dependent. It does not exhibit any inhibitory effect against PH domain-lacking Akts, or other closely related AGC family kinases, PKA, PKC, and SGK, even at concentrations as high as 50uM. Overcomes Akt1/Akt2-mediated resistance to chemotherapeutics in tumor cells and is shown to block basal and stimulated phosphorylation / activation of Akt1/Akt2 both in cultured cells in vitro and in mice in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 612847-09-3. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| Akt Inhibitor XIX, 3CAI (2-Chloro-1-(1H-indol-3-yl)-ethanone, 3-Chloroacetyl-indole) | A cell-permeable chloroacetyl-indole compound that inhibits Akt1 and Akt2 kinase activity (IC50 <1uM) by directly targeting Akt PH domain, exhibiting little or much reduced activity against a panel of 84 other kinases. Effectively inhibits Akt-mediated downstream effector proteins phosphorylation in a time-dependent manner, resulting in effective apoptosis induction in HCT116 and HT29 cultures (by 55% and 60%, respectively; 4uM for 4 days). Reported to retard HCT116-derived tumor growth in mice (EC50=30mg/kg; 5 times/wk for 3 wks via p.o.) in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 28755-03-5. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| α-Synuclein (34-45) (human) | The Parkinson's disease-associated protein α-synuclein (α-syn) is not only expressed in the cytoplasm of neurons, but also secreted in the extracellular space and internalized into glial cells through a lipid raft dependent process. The tilted peptide α-synuclein(67-78) has a high affinity with cholesterol and is toxic to cultured astrocytes. The glycosphingolipid-binding domain of alpha-synuclein (34-45) encapsulates a cholesterol-recognition consensus motif with a low affinity and no toxicity. Synonyms: α-syn (34-45) (human); H-Lys-Glu-Gly-Val-Leu-Tyr-Val-Gly-Ser-Lys-Thr-Lys-OH; L-Lysine, L-lysyl-L-α-glutamylglycyl-L-valyl-L-leucyl-L-tyrosyl-L-valylglycyl-L-seryl-L-lysyl-L-threonyl-. Grades: ≥95%. CAS No. 2170181-52-7. Molecular formula: C59H101N15O18. Mole weight: 1308.52. | |
| α-Synuclein (67-78) (human) | The Parkinson's disease-associated protein α-synuclein (α-syn) is not only expressed in the cytoplasm of neurons, but also secreted in the extracellular space and internalized into glial cells through a lipid raft dependent process. The tilted peptide α-synuclein(67-78) has a high affinity with cholesterol and is toxic to cultured astrocytes. The glycosphingolipid-binding domain of alpha-synuclein (34-45) encapsulates a cholesterol-recognition consensus motif with a low affinity and no toxicity. Synonyms: α-syn (67-78) (human); H-Gly-Gly-Ala-Val-Val-Thr-Gly-Val-Thr-Ala-Val-Ala-OH; L-Alanine, glycylglycyl-L-alanyl-L-valyl-L-valyl-L-threonylglycyl-L-valyl-L-threonyl-L-alanyl-L-valyl-. Grades: ≥95%. CAS No. 2243206-99-5. Molecular formula: C43H76N12O15. Mole weight: 1001.14. | |
| AM-36 | AM-36 is a potent blocker of batrachotoxinin (BTX)-sensitive Na+ channel binding in rat brain homogenates with an IC50 of 0.28 microM. As a unique neuroprotective agent with anti-oxidant activity, in neuronal cell cultures, AM-36 inhibited toxicity induced by N-methyl-D-aspartate (NMDA) and the sodium channel opener veratridine and, in addition, inhibited veratridine-induced apoptosis. Synonyms: 2,6-ditert-butyl-4-[[4-[2-(4-chlorophenyl)-2-hydroxyethyl]piperazin-1-yl]methyl]phenol; AM-36; AM 36; AM36; UNII-08OBY024NY; SCHEMBL12311270; CNSB 002; CNSB-002; CNSB002. Grades: >98%. CAS No. 199467-52-2. Molecular formula: C27H39ClN2O2. Mole weight: 459.06. | |
| Amino-PEG3-t-butyl ester (Propanoic acid, 3-[2-[2- (2-aminoethoxy) ethoxy]ethoxy]-, 1,1-dimethylethyl ester) | Applications in medical research, drug-release, nanotechnology, materials research and cell culture. In the study of ligand, polypeptide synthesis support, graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. Group: Biochemicals. Alternative Names: NH2-PEG3-CH2CH2COOtBu. Grades: Highly Purified. CAS No. 252881-74-6. Pack Sizes: 5g. Molecular Formula: C13H27NO5, Molecular Weight: 277.4. US Biological Life Sciences. | Worldwide |
| Amphotericin B Solution, 100X | Amphotericin B is a polyene antifungal agent for yeast, mold and mycoplasma. It was first isolated by Gold, et a., from Streptomyces nodosus in 1955. It is an amphoteric compound composed of a hydrophilic polyhydroxyl chain along one side and a lipophilic polyene hydrocarbon chain on the other. Amphotericin B is poorly soluble in water. Amphotericin B binds to sterols, preferentially to the primary fungal cell membrane sterol, ergosterol. This binding disrupts osmotic integrity of the fungal membrane, resulting in leakage of intracellular potassium, magnesium, sugars, and metabolites and then cellular death.Used in the preparation of baculoviral stocks.Amphotericin B Solution, 100X is composed of USP grade Amphotericin B in a High pH buffer (NaOH/Na+,H2O). The concentration of Amphotericin B in the final product is 0.25 g/L. Group: Biochemicals. Alternative Names: Abelcet; Abelecet; AmBisome; Ampho-Moronal; Amphocin; Amphozone; Apothecon; Fungilin; Fungizona; Fungizone; Halizon; LNS-AmB; NS 718; NSC 527017. Grades: Cell Culture Grade. CAS No. 1397-89-3. Pack Sizes: 50ml, 100ml. Molecular Formula: C47H73NO17, Molecular Weight: 924.09. US Biological Life Sciences. | Worldwide |
| AMPK Signaling Activator XIII, ZLN005 (2-(4-tert-Butylphenyl)-1H-benzo[d]imidazole, 2-(4-(2-Methyl-2-propanyl)phenyl)-1H-benzimidazole, Luciferase Inhibitor IV) | A cell-permeable benzimidazole that, in addition to its inhibitory potency against luciferase activity (IC50 <10nM), also activates AMPK signaling by increasing cellular ADP/ATP ratio via mitochondria respiration upcoupling, effectively activating AMPK & PGC-1alpha in muscle, but not liver, cell types both in cultures (5-20uM in rat L6 myotubes) in vitro and in db/db mice (15mg/kg/day via p.o.) in vivo. Reported to improve glucose and insulin tolerance of db/db mice without any apparent effects on body weight or food intake. Group: Biochemicals. Grades: Highly Purified. CAS No. 4529-96-8. Pack Sizes: 25mg. Molecular Formula: C??H??N?. US Biological Life Sciences. | Worldwide |
| Antimycin A | Antimycin A is an antibiotic that induces apoptosis. Derivatives of Antimycin A mediate selective toxicity toward cultured A549 human lung epithelial adenocarcinoma cells. Also, it inhibits mitochondrial electron transport. Group: Biochemicals. Alternative Names: Antipiricullin; Fintrol; Virosin. Grades: Purified. CAS No. 1397-94-0. Pack Sizes: 5mg, 25mg, 50mg, 100mg. Molecular Formula: C??H??N?O?R?R?, Molecular Weight: 548.63. US Biological Life Sciences. | Worldwide |
| Aortic Artery Endothelial Cells, Human (Frozen) | Passage 3 cells are shipped in proliferating culture with a confluence of >90%. ENDO-Growth medium containing 5% serum and growth supplement, is recommended for culture. Cells have an average population doubling level of >16 when cultured. Group: Biologicals. Grades: Cell Culture Grade. Pack Sizes: 1ml. US Biological Life Sciences. | Worldwide |
| Aortic Artery Endothelial Cells, Human (T-25 flask) | Passage 3 cells are shipped in proliferating culture with a confluence of >90%. ENDO-Growth medium containing 5% serum and growth supplement, is recommended for culture. Cells have an average population doubling level of >16 when cultured. Group: Biologicals. Grades: Cell Culture Grade. Pack Sizes: T-25 flask. US Biological Life Sciences. | Worldwide |
| ApoE4 Modulator, PH002 (Apolipoprotein E4 Structure Corrector, ApoE4 Structure Corrector, 4-{4-[2-(3-methyl-4-oxo-3,4-dihydro-phthalazin-1-yl)-acetylamido]-benzyl}-piperazine-1-carboxylic Acid Tert-butyl Ester) | A phthalazinone derived compound that directly binds to the 22kD amino-terminal region of apolipoprotein E4 (ApoE4) and blocks its intramolecular domain interactions in neuronal cells (IC50 = 116nM) thereby reversing the detrimental effects of ApoE4. Established to be more potent than GIND25. Restores mitochondrial functions and elevates the levels of complex IV subunit 1. Shown to increase in COX1 levels in primary neurons from NSE-ApoE4 transgenic mouse cortex and hippocampus. Shown to rescue impairments of mitochondrial motility in primary neurons from NSE-ApoE4 transgenic mice (~200nM). Also restores endoplasmic reticulum and Golgi apparatus transit of ApoE4 in cultured neurons and brings it to levels normally found in ApoE3 and ApoE4-R61T. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?, Molecular Weight: 491.6. US Biological Life Sciences. | Worldwide |
| Ascorbic Acid USP (L-Ascorbic acid, Vitamin C) | Physiological antioxidant. Coenzyme for a number of hydroxylation reactions; required for collagen synthesis. Widely distributed in plants and animals. Inadequate intake results in deficiency syndromes such as scurvy. Used as antimicrobial and antioxidant in foodstuffs. Group: Biochemicals. Alternative Names: (+)-Ascorbic Acid; 100M; L-threo-Ascorbic Acid. Grades: Cell Culture Grade. CAS No. 50-81-7. Pack Sizes: 100g, 250g, 500g, 1Kg, 2.5Kg, 5Kg. US Biological Life Sciences. | Worldwide |
| Atractyloside, Calcium Salt | Atractyloside Calcium Salt is a specific inhibitor of the adenine nucleotide translocase (ANT), which is a mitochondrial ADP/ATP carrier. It is also a proapoptotic ligand of ANT that induces pore formation by ANT, and results in permeabilization of the mitochondria membrane. Studies on rat hearts suggest that Atractyloside inhibits chloride channels from the mitochondrial membrane. It is used to probe the source of procaspase 8 in human fibroblasts and mouse clonal striatal cells, as related to death receptor-mediated apoptosis. Atractyloside induces the release of ahyaluronidase-induced murine WW domain-containing oxidoreductase from cultured COS-7 cells, with respect to tumor necrosis factor cytotoxicity. Group: Biochemicals. Alternative Names: (2 β,15α)-15-Hydroxy-2-[[2-O-(3-methyl-1-oxobutyl)-3,4-di-O-sulfo- β-D-glucopyranosyl]oxy]-19-Norkaur-16-en-18-oic Acid Calcium Salt; 19-Norkaur-16-en-18-oic acid deriv. 1H-2,10a-Ethanophenanthrene Calcium Salt. Grades: Highly Purified. CAS No. 772298-35-8 free acid. Pack Sizes: 500ug, 1mg. US Biological Life Sciences. | Worldwide |
| ATR Inhibitor IV (VE821, 3-amino-6- (4- (methylsulfonyl) phenyl) -N-phenylpyrazine-2-carboxamide, VE-821, ATM and Rad3-Related Inhibitor IV) | A cell-permeable phenylpyrazine derivative that acts as a potent, ATP-competitive (Ki= 13nM; IC50/[ATP] = 70nM/50uM and 128nM/100uM), ATR-selective inhibitor with much reduced or little potency against 4 related PIKKs (Ki= 2.2, 3.9, 16, and >1uM, respectively, against DNA-PK, PI 3-K-gamma, ATM, and mTOR) and 50 other kinases. Shown to selectively inhibit ATR-dependent H2AX Ser139 & Chk1 Ser345 phosphorylation (complete inhibition at 10uM in HT29 and HFL1 cultures) without affecting ATM- and DNA-PK-mediated H2AX or ATM-mediated Chk2 phosphorylation. Short-term (24h) VE-821 treatment, either alone or in synergy with Cisplatin, results in reversible cytostatic growth arrest regardless of cellular ATM-p53 pathway activity, while cytotoxicity and Cisplatin synergism in cell death induction is reported to occur only upon long-term VE-821 exposure (≥72h) in cultures with ATM-p53 pathway defects.CAS No.1232410-49-10. Group: Biochemicals. Grades: Highly Purified. CAS No. 1232410-49-10. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?S. US Biological Life Sciences. | Worldwide |
| Azido-PEG8-alcohol | O-(2-Azidoethyl)heptaethylene glycol (CAS# 352439-36-2) is used in the synthesis of heterobifunctionalized oligo(ethylene glycol) linkers for use in drug delivery. Uses: Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. in the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. monodisperse azide-peg8-alcohol (n3-peg8-oh) is a click chemistry reagent with an azide(n3) and a terminal hydroxyl (oh) group. the azide group is reactive with alkyne, bcn, dbco via click chemistry to yield a stable triazole linkage. the hydroxyl (oh) group enables further derivatization or replacement with other functional groups. Synonyms: N3-PEG8-OH; Azide-PEG8-alcohol; 2- [2- [2- [2- [2- [2- [2- (2-azidoethoxy) ethoxy] ethoxy] ethoxy] ethoxy] ethoxy] ethoxy] ethanol. Grades: >97%. CAS No. 352439-36-2. Molecular formula: C16H33N3O8. Mole weight: 395.45. | |
| Baceridin | Baceridin, a cyclic hexapeptide isolated from the culture medium of a plant-related bacillus strain, shows moderate cytotoxicity and weak activity against Staphylococcus aureus. In addition, it is a proteasome inhibitor that inhibits cell cycle progression and induces tumor cell apoptosis through a p53-independent pathway. Synonyms: Cyclo(D-alanyl-L-tryptophyl-L-leucyl-D-leucyl-L-valylisoleucyl); Cyclo(-D-Ala-D-allo-Ile-Val-D-Leu-Leu-Trp); cyclo[D-alanyl-L-tryptophyl-L-leucyl-D-leucyl-L-valyl-(3S)-DL-isoleucyl]. Grades: ≥95%. CAS No. 1622872-91-6. Molecular formula: C37H57N7O6. Mole weight: 695.89. | |
| Beclin-1 Activator I, TAT-Beclin-1 (Atg6 Activator I, Beclin1-GAPR-1 Interaction Blocker I, Vps30 Activator I, H2N-YGRKKRRQRRR-GG-TNVFNATFEIWHDGEFGT-CO2H) | A cell-permeable autophagy-inducing peptide (Effective conc. 30 to 100uM) that is designed based on the essential HIV-1 virulence factor Nef-binding sequence of atg6/beclin1 and N-terminally fused to the HIV-1 Tat protein transduction domain sequence. Tat-Beclin1 is reported to compete against Beclin1 for binding to its negative regulator GAPR-1/GLIPR2 on the Golgi surface. Shown to effectively induce autophagy-mediated clearance of small (<1uM) CFP-htt103Q aggregates in HeLa cells (20uM/4h/d for 2 d) and inhibit RNA viral replications both in cultures (4h 10uM peptide treatment 4h post CHIKV, SINV, or WNV infection in HeLa cultures; 24h 0.5-5uM peptide pre-treatment before HIV infection in human MDM cultures) in vitro and in mice (15-20mg/kg/day i.p.) in vivo. The in vivo bioavailability of Tat-Beclin1 is limited to the peripheral tissues in mice, while a peptide based on Tat-Beclin1 retro-inverso sequence is demonstrated to effectively target CNS. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C???H???N??O??, Sequence: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg~Gly-Gly~Thr-Asn-Val-Phe-Asn-Ala-Thr-Phe-Glu-Ile-Trp-His-Asp-Gly-Glu-Phe-Gly-Thr-OH. US Biological Life Sciences. | Worldwide |
| Bestatin trifluoroacetate | Bestatin, also known as Ubenimex (INN), is a competitive protease inhibitor. It is an inhibitor of aminopeptidase B, leukotriene A4 hydrolase, aminopeptidase N. It is being studied for use in the treatment of acute myelocytic leukemia. Bestatin can be administered, with low toxicity, to cultured cells, intact animals and humans. It has become a useful tool in elucidating the physiological role of some mammalian exopeptidases in the regulation of the immune system, in the growth of tumors and their invasion of surrounding tissues, and in the degradation of cellular proteins. Synonyms: Ubenimex trifluoroacetate. Grades: >98%. CAS No. 223763-80-2. Molecular formula: C18H25F3N2O6. Mole weight: 422.4. | |
| Beta-Ala-Lys-AMCA | Fluorescent dipeptide derivative, which could be used as an excellent reporter molecule for studying the oligopeptide transport system in brain cell cultures. Group: Biochemicals. Alternative Names: b-Ala-(L)-Lys-N-7-amino-4-methylcoumarin-3-acetic acid; b-Ala-Lys-Nε-AMCA; ß-Ala-Lys-Nε-AMCA; β-Alanyl-Nε-(7-Amino-4-Methyl-2-Oxo-2H-1-Benzopyran-3-Acetyl)-L-Lysine. Grades: Highly Purified. Pack Sizes: 1mg, 5mg. Molecular Formula: C21H28N4O6, Molecular Weight: 432.47. US Biological Life Sciences. | Worldwide |
| β-Amyloid (1-40) | Amyloid β-Peptide (1-40) (human) is a 40-residue protein fragment of the C-terminal portion of the β-amyloid protein, which is found in plaques in the brains of patients with Alzheimer's disease. It is neurotrophic and neurotoxic in vivo and in vitro in human and rat neuronal cell cultures. It prevented neuronal cell death by inhibiting fibril formation when administered concurrently with Aβ (1-42) in rat cortical cultures at 3 μM. It prevented neuronal damage when injected into rat entorhinal cortex with Aβ (1-42) both at 400 μM. Synonyms: Amyloid β Protein Fragment 1-40; Aβ40. Grades: 95%. CAS No. 131438-79-4. Molecular formula: C194H295N53O58S. Mole weight: 4329.8599999999997. | |
| β-Glycerophosphate, Disodium Salt, Pentahydrate ( β-GP, Disodium Glycero-2-phosphate Pentahydrate) | β-Glycerophosphate, Disodium Salt, Pentahydrate ( β-GP, Disodium Glycero-2-phosphate Pentahydrate). Group: Biochemicals. Alternative Names: 2-(Dihydrogen phosphate) 1,2,3-Propanetriol Sodium Salt Pentahydate; Sodium β-glycerophosphate pentahydrate; β-GP. Grades: Cell Culture Grade. CAS No. 13408-09-8. Pack Sizes: 25g, 100g, 250g. Molecular Formula: C3H7O6PNa2 5H2O, Molecular Weight: 306.1. US Biological Life Sciences. | Worldwide |
| b-Glycerophosphate Disodium Salt Hydrate 99+% | Used as an organic phosphate donor and to buffer cell culture media. Group: Biochemicals. Alternative Names: Glycerol 2-phosphate disodium salt hydrate. Grades: Reagent Grade. CAS No. 154804-51-0. Pack Sizes: 5g, 25g, 100g, 250g. Molecular Formula: C3H7Na2O6P; xH2O, Molecular Weight: 234. US Biological Life Sciences. | Worldwide |
| Biotin (D-Biotin, Vitamin H, Coenzyme R, Bioepiderm) | Biotin is used as a growth factor in mammalian cell culture as well as having numerous immunological purification roles in avidin/streptavidin-biotin binding mechanisms. Biotin, also known as vitamin H or B7, is a water-soluble B-complex vitamin which is composed of an ureido (tetra hydroimidizalone) ring fused with a tetrahydrothiophene ring. A valeric acid substituent is attached to one of the carbon atoms of the tetrahydrothiophene ring. Biotin is a cofactor in the metabolism of fatty acids and leucine, and it plays a role in gluconeogenesis. Biotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids. It plays a role in the citric acid cycle, which is the process by which biochemical energy is generated during aerobic respiration. Biotin not only assists in various metabolic reactions, but also helps to transfer carbon dioxide. Biotin is also helpful in maintaining a steady blood sugar level. Biotin is often recommended for strengt Group: Biochemicals. Alternative Names: (3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanoic Acid; (+)-Biotin; Vitamin B7; Coenzyme R; D(+)-Biotin; Factor S; Lutavit H2; Meribin; NSC 63865; Rovimix H2. Grades: Molecular Biology Grade. CAS No. 58-85-5. Pack Sizes: 1g, 5g, 10g, 25g. Molecular Formula: C??H??N?O?S, Molecular Weight: 244.31. US Biological Life Sciences. | Worldwide |
| Biotin (Glucose Oxidase) | Biotin is used as a growth factor in mammalian cell culture as well as having numerous immunological purification roles in avidin/streptavidin-biotin binding mechanisms. Biotin, also known as vitamin H or B7, is a water-soluble B-complex vitamin which is composed of an ureido (tetra hydroimidizalone) ring fused with a tetrahydrothiophene ring. A valeric acid substituent is attached to one of the carbon atoms of the tetrahydrothiophene ring. Biotin is a cofactor in the metabolism of fatty acids and leucine, and it plays a role in gluconeogenesis. Biotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids. It plays a role in the citric acid cycle, which is the process by which biochemical energy is generated during aerobic respiration. Biotin not only assists in various metabolic reactions, but also helps to transfer carbon dioxide. Biotin is also helpful in maintaining a steady blood sugar level. Biotin is often recommended for strengt Group: Biochemicals. Alternative Names: Vitamin H, Coenzyme R, Bioepiderm. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Bisindolylmaleimide VIII acetate | Selective protein kinase C (PKC) inhibitor. Inhibits proliferation of cultured mouse epidermal keratinocytes. Enhances Fas- and TRAIL-mediated apoptosis. Inhibits T cell-mediated autoimmune diseases. Inhibits stimulation of insulin secretion by glucose. Inhibits panel of protein kinases (e.g. GSK-3beta, CDK2). Group: Biochemicals. Alternative Names: Ro 31-7549, BIM VIII. Grades: Highly Purified. CAS No. 138516-31-1. Pack Sizes: 1mg, 5mg. Molecular Formula: C24H22N4O2. CH3COOH. US Biological Life Sciences. | Worldwide |
| Bis-PEG6-acid (4, 7, 10, 13, 16, 19, 22-Heptaoxapentacosane dioic acid) | Applications in medical research, drug-release, nanotechnology, materials research and cell culture. In the study of ligand, polypeptide synthesis support, graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. Group: Biochemicals. Alternative Names: COOH-PEG6-COOH. Grades: Highly Purified. CAS No. 94376-75-7. Pack Sizes: 1g. Molecular Formula: C18H34O11, Molecular Weight: 426.46. US Biological Life Sciences. | Worldwide |
| Bladder Microvascular Endothelial Cells, Human (Frozen) | Passage 3 cells are shipped in proliferating culture with a confluence of >90%. ENDO-Growth medium containing 5% serum and growth supplement is recommended for culture. Cells have an average population doubling level of >16 when cultured. Group: Biologicals. Grades: Cell Culture Grade. Pack Sizes: 1ml. US Biological Life Sciences. | Worldwide |
| Bladder Microvascular Endothelial Cells, Human (T-25 flask) | Passage 3 cells are shipped in proliferating culture with a confluence of >90%. ENDO-Growth medium containing 5% serum and growth supplement is recommended for culture. Cells have an average population doubling level of >16 when cultured. Group: Biologicals. Grades: Cell Culture Grade. Pack Sizes: T-25 flask. US Biological Life Sciences. | Worldwide |
| Bmi1-Ring1A E3 Ligase Inhibitor, PRT4165 (2-(Pyridin-3-ylmethylene)-1H-indene-1,3(2H)-dione) | A cell-permeable indandione compound that inhibits the Bmi1-Ring1A E3 complex ubiquitin ligase activity both in cell-free assays (by 100% against self- and Top2alpha ubiquitination at 25 and 50uM, respectively) and in HeLa cells (by 100% against Bmi1 ubiquitination at 50uM). Shown to greatly potentiate Teniposide (VM26) cancer cytotoxicity (by 10-fold in A375 and A549 cultures at 5.5 and 33uM, respectively) by preventing Top2alpha degradation following VM26 treatment (100% inhibition at 50uM in HeLa cells). Group: Biochemicals. Grades: Highly Purified. CAS No. 31083-55-3. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
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