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| Product | Description | |
|---|---|---|
| Checkpoint Kinase 2, Active human | buffered aqueous glycerol solution, recombinant, expressed in E. coli, ?85% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. |  |
| Checkpoint Kinase 2, Active Human, Recombinant | CHEK2 is the official symbol for the human gene Checkpoint kinase 2. CHEK2 is located on the the long (q) arm of chromosome 22. CHEK2 is tumor suppressor gene that encodes the protein CHK2, a serine threonine kinase. CHK2 operates in an intricate network of proteins to elicit DNA repair, cell cycle arrest or apoptosis in response to DNA damage. Mutations to the CHEK2 gene have been linked to a wide range of cancers including breast cancer. Buffered aqueous glycerol solution, recombinant, expressed in e. coli, > 85% (sds-page). Applications: Kinase activity is measured as the molar amount of phosphate incorporated into the chktide per minute per mg protein at 30°c using a final concentration of 50 μm [32p] atp. Group: Enzymes. Synonyms: Checkpoint Kinase 2; CHEK2; CDS1; CHK2; HuCds1; LFS2; PP1425; RAD53; hCds1; Chek2; Chk2. Purity: > 85% (SDS-PAGE). CHEK2. Mole weight: protein apparent mol wt ~88 kDa. Stability: -70°C. Form: buffered aqueous glycerol solution. Source: E. coli. Species: Human. Checkpoint Kinase 2; CHEK2; CDS1; CHK2; HuCds1; LFS2; PP1425; RAD53; hCds1; Chek2; Chk2. Cat No: NATE-0122. |  |
| Checkpoint Protein Hus1 (213-232) (human) | HDAC1 plays an important role in regulating eukaryotic chromatin structure and specifically interacts with human Hus1 gene products in yeast, mammalian cells, and in vitro. S. Pombe's Hus1 protein is associated with G2/M checkpoint control and is a member of the cell cycle checkpoint Rad protein, which is involved in the mitotic checkpoint induced by DNA damage or DNA replication arrest. Synonyms: H-Leu-Ala-Ser-Glu-Ser-Thr-His-Glu-Asp-Arg-Asn-Val-Glu-His-Met-Ala-Glu-Val-His-Ile-OH. Grade: ≥95%. Molecular formula: C95H150N30O35S. Mole weight: 2304.48. |  |
| 10Z-Hymenialdisine | Insecticidal and cytotoxic. Potent NF-kappaB inhibitor. Inhibits various pro-inflammatory cytokines such as IL-1, IL-2, IL-6, IL-8, TNF-alpha and nitric oxide (NO) in a variety of cell lines. ATP-competitive kinase inhibitor. Inhibits DNA damage checkpoint at G2, cyclin-dependent kinases CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, CDK5/p25, GSK-3beta and casein kinase 1 (CK1). Potent mitogen-activated protein kinase kinase-1 (MEK-1) inhibitor. MARK (microtubule affinity-regulating kinase) inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 82005-12-7. Pack Sizes: 500ug, 1mg. Molecular Formula: C??H??BrN?O?, Method for Determining. US Biological Life Sciences. |  Worldwide |
| 10Z-Hymenialdisine (Hymenialdisine, 4-(2-Amino-4-oxo-2-imidazolidin-5-ylidene)-2-bromo-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8-one) | Isolated from sponge Axinella carteri. A potent inhibitor of mitogen-activated protein kinase kinase-1 (MEK-1) (IC50=6nm). Blocks the in vivo phosphorylation of the microtubule-binding protein tau at sites that are hyperphosphorylated by glycogen synthase kinase-b (GSK-3b) and CDK5/p35 in Alzheimers disease. Inhibitor of DNA damage checkpoint at G2 phase (IC50=6uM), cyclin-dependent kinases CDK1/cyclin B (IC50=22nm), CDK2/cyclin A (IC50=70 nm), CDK2/cyclin E (IC50=40nm), CDK4/cyclin D1 (IC50 = 600nm), CDK5/p25 (IC50=28nm), GSK-3b (IC50=10nm), and casein kinase 1 (CK1) (IC50=35nm). Group: Biochemicals. Grades: Highly Purified. CAS No. 82005-12-7. Pack Sizes: 250ug, 1mg. US Biological Life Sciences. | Worldwide |
| 2-Bromothiazole-5-carboxaldehyde | 2-Bromothiazole-5-carboxaldehyde is a reactant in the preparation of thienopyridines as potent checkpoint 1 kinase (CHK1) inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 464192-28-7. Pack Sizes: 250mg, 500mg. Molecular Formula: C4H2BrNOS, Molecular Weight: 192.03. US Biological Life Sciences. | Worldwide |
| 2OH-BNPP1 | 2OH-BNPP1 is a novel inhibitor of checkpoint kinase BUB1. Group: Biochemicals. Grades: Highly Purified. CAS No. 833481-73-5. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C16H19N5O, Molecular Weight: 297.35. US Biological Life Sciences. | Worldwide |
| 2-Oxa-7-azaspiro[3.5]nonane | 2-Oxa-7-azaspiro[3.5]nonane is an intermediate used to prepare benzothienoazepine derivatives as potent respiratory syncytial virus RNA polymerase inhibitors. It is also used to prepare 1,7-Diazacarbazole derivatives as inhibitors of checkpoint kinase 1. Group: Biochemicals. Grades: Highly Purified. CAS No. 241820-91-7. Pack Sizes: 10mg, 50mg. Molecular Formula: C7H13NO, Molecular Weight: 127.18. US Biological Life Sciences. | Worldwide |
| (2S,3S,4S,5S)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate | (2S,3S,4S,5S)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate is a potential drug candidate used in biomedicine for treating cancer. It is a small molecule inhibitor of WEE1, a protein kinase that regulates the G2/M checkpoint of the cell cycle. Inhibition of WEE1 leads to the activation of CDK1 and CDK2, causing DNA damage and cell death in cancer cells. Synonyms: (2S,3S,4S,5S)-5-(4-benzoylamino-2-oxopyrimidine-1(2H)-yl)-2-((benzoyloxy)methyl)-4-Fluoro-4-methyltetrahydrofuran-3-yl benzoate. Grade: 97%. Molecular formula: C31H26FN3O7. Mole weight: 571.55. | |
| 3,3'-Diindolylmethane | 3,3'-Diindolylmethane is an activator of checkpoint kinase 2 (Chk2) that induces G2/M cell cycle arrest in various cancer cell lines. It is used as an antineoplastic agent. Nutritional supplement in health care products. Synonyms: 1H-Indole, 3,3'-methylenebis-; 3,3'-Methylenebis[1H-indole]; Indole, 3,3'-methylenedi-; 3,3'-Bisindolylmethane; 3,3'-Methanediyldi(1H-indole); Arundine; Bis(1H-indol-3-yl)methane; Bis(3-indolyl)methane; Cervicon-DIM; Di(1H-indol-3-yl)methane; Diindolylmethane; DIM; DIM (AhR agonist); DIM (diindolylmethane); HB 236; Infemin. Grade: ≥99% by HPLC. CAS No. 1968-5-4. Molecular formula: C17H14N2. Mole weight: 246.31. | |
| 8-[(6-Amino)hexyl]-amino-adenosine-2',5'-bisphosphate - DYQ-661 | DYQ-661, a strikingly potent and exclusive inhibitor of CD73, a critical enzyme implicated in the biosynthesis of immunosuppressive adenosine in the tumor microenvironment, presents a hopeful alternative for patients with different types of cancer. The preclinical investigations depict handsome outcomes, enhancing the effectiveness of immune checkpoint inhibitors. DYQ-661 is an exceedingly promising therapeutic approach that demands significant attention in the realm of cancer treatment. Synonyms: 8-[(6-Amino)hexyl]-amino-adenosine-2',5'-bisphosphate, labeled with DYQ 661, Triethylammonium salt. Grade: ≥ 95% by HPLC. Molecular formula: C55H70N9O18P2S2 (Anion). Mole weight: 1271.27 (Anion). | |
| AHR Antagonist 5 | AHR Antagonist 5, an effective and orally active aromatic hydrocarbon receptor (AHR) antagonist with IC50 of less than 0.5 μM. It can significantly inhibit tumor growth in combination with the checkpoint inhibitor anti-PD-1. Synonyms: BCP33104; HY-136220; CS-0120848; (R)-N-(2-(5-Fluoropyridin-3-Yl)-8-Isopropylpyrazolo[1,5-A][1,3,5]Triazin-4-Yl)-2,3,4,9-Tetrahydro-1H-Carbazol-3-Amine Trihydrochloride. Grade: ≥98% by HPLC. CAS No. 2247953-39-3. Molecular formula: C25H27Cl3FN7. Mole weight: 550.9. | |
| AHR antagonist 5 hemimaleate | AHR antagonist 5 hemimaleate is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist with an IC50 of < 0.5 μΜ. AHR antagonist 5 hemimaleate significantly inhibits tumor growth combined with checkpoint inhibitor anti-PD-1. Molecular formula: C29H28FN7O4. Mole weight: 499.55. | |
| Alsevalimab | Alsevalimab is a human monoclonal antibody that targets B7-H4 with potential antineoplastic and immune checkpoint inhibitory activities. CAS No. 2254029-91-7. | |
| AMG510 racemate | AMG510 is a potent KRAS G12C covalent inhibitor with potential antineoplastic activity. At the 2019 World Conference on Lung Cancer (WCLC), Amgen declared the efficacy of AMG510 for treating non-small cell lung cancer (NSCLC) with KRAS G12 C-mutated solid tumors. Amgen also announced prospective directions for AMG510 through academic scholars and reports the few limitations on official drug release as evidence for potential investors to consider the value of AMG510. Uses: Immune checkpoint inhibitors. Synonyms: AMG-510 racemate; AMG 510 racemate; Sotorasib racemate. CAS No. 2296729-00-3. Molecular formula: C30H30F2N6O3. Mole weight: 560.59. | |
| ANI-7 | ANI-7, an activator of aryl hydrocarbon receptor (AhR) pathway, inhibits the growth of multiple cancer cells, and potently and selectively inhibits the growth of MCF-7 breast cancer cells with a GI50 of 0.56 μM. ANI-7 induces CYP1 metabolic monooxygenase by activating the AhR pathway, and induces DNA damage, checkpoint kinase (Chk2) activation, S-phase cell cycle arrest, and cell death in sensitive breast cancer cell lines. Synonyms: (alphaZ)-alpha-(3,4-Dichlorophenyl)-1H-pyrrole-2-acrylonitrile; (2Z)-2-(3,4-Dichlorophenyl)-3-(1H-pyrrol-2-yl)acrylonitrile; Benzeneacetonitrile, 3,4-dichloro-α-(1H-pyrrol-2-ylmethylene)-, (αZ)-; (Z)-2-(3,4-dichlorophenyl)-3-(1H-pyrrol-2-yl)acrylonitrile; (αZ)-3,4-Dichloro-α-(1H-pyrrol-2-ylmethylene)benzeneacetonitrile. Grade: ≥95%. CAS No. 931417-26-4. Molecular formula: C13H8Cl2N2. Mole weight: 263.12. | |
| ARRY-520 R enantiomer | ARRY-520 R enantiomer is the R form of ARRY-520, which is a synthetic, small molecule kinesin spindle protein (KSP) inhibitor. ARRY-520 had low nanomolar antiproliferative activity in tumor cell lines and specifically inhibits KSP (kinesin-5 or Eg5), resulting in activation of the spindle assembly checkpoint, induction of cell cycle arrest during the mitotic phase, and consequently cell death in tumor cells that are actively dividing. Synonyms: ARRY-520 R enantiomer; ARRY 520 R enantiomer; ARRY520 R enantiomer; 1,3,4-Thiadiazole-3(2H)-carboxamide, 2-(3-aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-, (2R)-. Grade: >98%. CAS No. 885060-08-2. Molecular formula: C20H22F2N4O2S. Mole weight: 420.48. | |
| AZD0156 | AZD0156 is an orally active, potent and selective ataxia telangiectasia mutated (ATM) kinase inhibitor, used for cancer treatment. AZD0156 prevents DNA damage checkpoint activation, and disrupts DNA damage repair, inducing tumor cell apoptosis, and leading to cell death in ATM-overexpressing tumor cells. Uses: Protein kinase inhibitors. Synonyms: 8-[6-[3-(dimethylamino)propoxy]-3-pyridyl]-3-methyl-1-tetrahydropyran-4-yl-imidazo[4,5-c]quinolin-2-one; AZD0156; AZD-0156; AZD 0156. CAS No. 1821428-35-6. Molecular formula: C26H31N5O3. Mole weight: 461.56. | |
| AZD0156 | AZD0156 is a potent, selective and orally active ATM inhibitor with an IC 50 of 0.58 nM. AZD0156 inhibits the ATM -mediated signaling, prevents DNA damage checkpoint activation, disrupts DNA damage repair, and induces tumor cell apoptosis [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1821428-35-6. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100016. |  |
| AZD-7762 | AZD-7762 is a potent ATP-competitive checkpoint kinase (Chk) inhibitor in with an IC50 of 5 nM for Chk1. Uses: Scientific research. Group: Signaling pathways. CAS No. 860352-01-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10992. | |
| AZD-7762 | AZD-7762 is a synthetic small molecule inhibitor of checkpoint kinases (Chks) with potential chemosensitizing activity. AZD7762 binds to and inhibits Chks, which may prevent cell cycle arrest and subsequent nucleotide excision repair in DNA-damaged tumor cells, resulting in tumor cell apoptosis. Synonyms: AZD 7762; AZD7762. Grade: 0.98. CAS No. 860352-01-8. Molecular formula: C17H19FN4O2S. Mole weight: 362.423. | |
| Besifloxacin Impurity G | Besifloxacin Impurity G is an intermediate used to prepare ureido thiophene carboxamides as checkpoint kinase inhibitors. It is also an impurity of Besifloxacin. Synonyms: (R)-3-Amino-hexahydroazepine; (R)-Azepan-3-amine; (R)-Hexahydro-1H-azepin-3-amine; (R)-3-Amino-Hexahydro-1H-Azepin; 1H-Azepin-3-amine, hexahydro-, (3R)-. Grade: > 95%. CAS No. 124932-43-0. Molecular formula: C6H14N2. Mole weight: 114.19. | |
| BML-277 | BML-277 is a selective checkpoint kinase 2 (Chk2) inhibitor with an IC50 of 15 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Chk2 Inhibitor II. CAS No. 516480-79-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-13946. | |
| BMS-1166 | BMS-1166 is a potent PD-1/PD-L1 immune checkpoint inhibitor. BMS-1166 induces dimerization of PD-L1 and blocks its interaction with PD-1, with an IC50 of 1.4 nM. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1818314-88-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-102011. | |
| BMS-502 | BMS-502 is an inhibitor of diacylglycerol kinase α (DGK-α), DGK-ζ, and DGK-Ι with IC50s of 0.0046, 0.0021, and 0.0026 μM, respectively. BMS-502 induces immune responses in human and mouse T cells and blocks intracellular checkpoint signaling in T cells. Synonyms: BMS 502; BMS502. CAS No. 2407854-18-4. Molecular formula: C27H22F2N6O3. Mole weight: 516.50. | |
| BO-264 | BO-264 is a highly potent and orally active transforming acidic coiled-coil 3 (TACC3) inhibitor with an IC50 of 188 nM and a Kd of 1.5 nM. BO-264 demonstrated superior anti-proliferative activity to the two currently reported TACC3 inhibitors, especially in aggressive breast cancer subtypes, basal and HER2+, via spindle assembly checkpoint (SAC)-dependent mitotic arrest, DNA damage and apoptosis, while the cytotoxicity against normal breast cells was negligible. Uses: Designed for use in research and industrial production. Additional or Alternative Names: BO-264; BO 264; BO264. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2408648-20-2. Molecular formula: C18H19N5O3. Mole weight: 353.38. Purity: >98%. IUPACName: 3-(4-methoxyphenyl)-N-(2-morpholinopyrimidin-4-yl)isoxazol-5-amine. Canonical SMILES: COC1=CC=C(C2=NOC(NC3=NC(N4CCOCC4)=NC=C3)=C2)C=C1. Product ID: ACM2408648202. Alfa Chemistry ISO 9001:2015 Certified. Categories: BF 2649. |  |
| BO-264 | BO-264 is a highly potent and orally active transforming acidic coiled-coil 3 (TACC3) inhibitor with an IC50 of 188 nM and a Kd of 1.5 nM. BO-264 specifically blocks the function of FGFR3-TACC3 fusion protein. BO-264 induces spindle assembly checkpoint (SAC)-dependent mitotic arrest, DNA damage and apoptosis. BO-264 has broad-spectrum antitumor activity[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2408648-20-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135960. | |
| BOS172722 | BOS172722 is a potent and selective monopolar spindle 1 (MPS1) checkpoint inhibitor with IC50 of 11 nM. Synonyms: BOS-172722; BOS 172722; N2-(2-Ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-6-methyl-N8-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine. CAS No. 1578245-44-9. Molecular formula: C24H30N8O. Mole weight: 446.55. | |
| CA-170 | CA-170 is an orally delivered dual inhibitor of VISTA and PD-L1. CA-170 exhibits potent rescue of proliferation and effector functions of T cells inhibited by PD-L1/L2 and VISTA with selectivity over other immune checkpoint proteins as well as a broad panel of receptors and enzymes[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1673534-76-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101093. | |
| Camrelizumab | Camrelizumab is an anti-PD-1 immune checkpoint inhibitor that is being investigated for hepatocellular carcinoma and Hodgkin lymphoma. Camrelizumab is a humanized anti-PD-1 IgG4 antibody that blocks the binding of PD-L1 and PD-L2 to PD-1 with immune checkpoint inhibitory and antineoplastic activities. Synonyms: Immunoglobulin G4, anti-(cell surface receptor) (human-Mus musculus monoclonal SHR-1210 heavy chain), disulfide with human-Mus musculus monoclonal SHR-1210 light chain, dimer; AiRuiKa; HR 301210; Immunoglobulin G4, anti-(human programmed cell death protein 1) (human-Mus musculus monoclonal SHR-1210 heavy chain), disulfide with human-Mus musculus monoclonal SHR-1210 light chain, dimer; INCSHR 01210; INCSHR 1210; INCSHR01210; SHR 1210. Grade: ≥98%. CAS No. 1798286-48-2. | |
| CBP501 | CBP501 is a peptide with G2 checkpoint-abrogating activity. G2 checkpoint inhibitor CBP501 inhibits multiple serine/threonine kinases, including MAPKAP-K2, C-Tak1, and CHK1, that phosphorylate serine 216 of the dual-specific phosphatase Cdc25C (cell division checkpoint 25 C); disruption of Cdc25C activity results in the inhibition of Cdc25C dephosphorylation of the mitotic cyclin-dependent kinase complex Cdc2/cyclin B, preventing entry into the mitotic phase of the cell cycle. Check for active clinical trials or closed clinical trials using this agent. Synonyms: CBP-501; CBP 501; H-D-Bpa-D-Ser-D-Trp-D-Ser-D-Phe(F5)-D-Cha-D-Arg-D-Arg-D-Arg-D-Gln-D-Arg-D-Arg-OH. CAS No. 565434-85-7. Molecular formula: C86H122F5N29O17. Mole weight: 1929.06. | |
| CBP-93872 | CBP-93872 is a G2 checkpoint inhibitor. CBP-93872 specifically abrogates the DNA double-stranded break (DSB)-induced G2 checkpoint through inhibiting maintenance. CBP-93872 is an inhibitor of maintenance of the DSB-specific G2 checkpoint and thus might be a strong candidate as the basis for a drug that specifically sensitizes p53-mutated cancer cells to DSB-inducing DNA damage therapy. Synonyms: CBP 93872; CBP93872; 1-amino-3-((2-bromo-4-methylphenyl)amino)propan-2-ol. Grade: 98%. CAS No. 67427-51-4. Molecular formula: C10H15BrN2O. Mole weight: 259.14. | |
| CHK1-IN-2 | CHK1-IN-2 is an inhibitor of checkpoint kinase 1 (CHK1), with an IC50 of 6 nM. Synonyms: Thieno[3,2-c]pyridine-7-carboxamide, 4-[[(2R,3S)-2-methyl-3-piperidinyl]amino]-2-phenyl-; 4-{[(2R,3S)-2-Methyl-3-piperidinyl]amino}-2-phenylthieno[3,2-c]pyridine-7-carboxamide. Grade: ≥95%. CAS No. 912367-45-4. Molecular formula: C20H22N4OS. Mole weight: 366.48. | |
| CHK1-IN-3 | CHK1-IN-3 is an inhibitor of Checkpoint Kinase 1 (CHK1) with an IC50 of 0.4 nM. Synonyms: 2-Pyridinecarbonitrile, 5-[[4-(methylamino)-5-(1-methyl-1H-pyrazol-4-yl)-2-pyrimidinyl]amino]-3-[(3R)-3-piperidinyloxy]-; 5-{[4-(Methylamino)-5-(1-methyl-1H-pyrazol-4-yl)-2-pyrimidinyl]amino}-3-[(3R)-3-piperidinyloxy]-2-pyridinecarbonitrile. Grade: ≥95%. CAS No. 2097252-39-4. Molecular formula: C20H23N9O. Mole weight: 405.46. | |
| CHK1-IN-4 | CHK1-IN-4, a potent checkpoint kinase 1 (chk1) inhibitor, potently inhibits chk1 phosphorylation in the tumor cells. It has antitumor activity. Synonyms: 2-Pyrazinecarbonitrile, 5-[[5-[2-(3-aminopropoxy)-4-bromo-6-methoxyphenyl]-1H-pyrazol-3-yl]amino]-; 5-({5-[2-(3-Aminopropoxy)-4-bromo-6-methoxyphenyl]-1H-pyrazol-3-yl}amino)-2-pyrazinecarbonitrile. Grade: ≥95%. CAS No. 2120398-41-4. Molecular formula: C18H18BrN7O2. Mole weight: 444.29. | |
| Chk1-IN-5 | Chk1-IN-5, a potent checkpoint kinase 1 (Chk1) inhibitor, inhibits Chk1 phosphorylation, and inhibits tumor growth in xenograft model of colon cancer. Synonyms: 5-((5-(2-(3-aminopropoxy)-4-fluoro-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)pyrazine-2-carbonitrile; 2-Pyrazinecarbonitrile, 5-[[5-[2-(3-aminopropoxy)-4-fluoro-6-methoxyphenyl]-1H-pyrazol-3-yl]amino]-. Grade: ≥95%. CAS No. 2120398-39-0. Molecular formula: C18H18FN7O2. Mole weight: 383.38. | |
| CHK1 inhibitor | CHK1 inhibitor is a checkpoint kinase 1 (CHK1) inhibitor. Synonyms: GDC-0575 analog; Cyclopropanecarboxamide, N-[4-[(3R)-3-amino-1-piperidinyl]-5-bromo-1H-indol-3-yl]-; N-{4-[(3R)-3-Amino-1-piperidinyl]-5-bromo-1H-indol-3-yl}cyclopropanecarboxamide. Grade: ≥95%. CAS No. 2097938-64-0. Molecular formula: C17H21BrN4O. Mole weight: 377.28. | |
| Chk2 Inhibitor | Chk2 inhibitor is an inhibitor of checkpoint kinase 2 (Chk2; IC50 = 13.5 nM). Chk2 inhibitor enhances survival of 184B5, but not MDA-MB-231, cells following ionizing radiation and inhibits cell cycle arrest at the G2 stage induced by ionizing radiation in 184B5 cells. It also inhibits the production of IL-2 in Jurkat cells, the production of TNF-α in LPS-stimulated THP-1 cells and the growth of CEM leukemia T cells. Synonyms: SC-203885; (5Z)-5-(2-amino-1,5-dihydro-5-oxo-4H-imidazol-4-ylidene)-3,4,5,10-tetrahydro-azepino[3,4-b]indol-1(2H)-one; Hymenialdisine Analogue 1. CAS No. 724708-21-8. Molecular formula: C15H13N5O2. Mole weight: 295.3. | |
| Cobolimab | Cobolimab is a monoclonal antibody directed against the inhibitory T-cell receptor, T-cell immunoglobulin and mucin domain-containing protein 3 (TIM-3), with potential immune checkpoint inhibitory and antineoplastic activities. Cobolimab has the potential for the treatment of non-small cell lung cancer (NSCLC). Synonyms: TSR-022; TSR 022; TSR022; GSK-4069889; GSK 4069889; GSK4069889. Grade: 95%. CAS No. 2022215-65-0. | |
| CTLA-4 inhibitor | CTLA-4 inhibitor is an inhibitor of CTLA-4, an immune checkpoint negatively regulating T cell function. CTLA-4 is thought to regulate T-cell proliferation early in an immune response, primarily in lymph nodes. Synonyms: MDK24720; MDK 24720; MDK-24720; CTLA-4 inhibitor. 2-(4-Fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one; EX-A913. CAS No. 635324-72-0. Molecular formula: C21H13F4N5O. Mole weight: 427.363. | |
| Debromohymenialdisine | Protein kinase C (PKC) inhibitor. Inhibits the ATP binding site. Cytotoxic and insecticidal. G2 DNA damage checkpoint inhibitor. Check point kinases 1 (Chk1) and 2 (Chk2) inhibitor. Does not inhibit ataxia-telangiectasia mutated (ATM) or ATM-Rad3-related proteins. MAP kinase kinase 1 (MEK-1) inhibitor. Interleukin-1 (IL-1) inhibitor. Anti-osteoarthritic. Potential anti-Alzheimer agent. Group: Biochemicals. Grades: Highly Purified. CAS No. 75593-17-8, 125118-55-0. Pack Sizes: 100ug. Molecular Formula: C11H11N5O2. US Biological Life Sciences. | Worldwide |
| eIF4E-IN-1 | eIF4E-IN-1, a potent eIF4E inhibitor, inhibits immunosuppression components such as the immune checkpoint proteins PD-1, PD-L1, LAG3, TIM3, and/or IDO, in order to inhibit or release immunosuppression in certain diseases, such as cancer and infectious diseases. (Extracted from patent WO2021003194A1, compound Y). Synonyms: Thieno[3,2-b]pyridine-3-carboxylic acid, 7-[5-chloro-2-[2-[5-cyano-2-methyl-6-(4-methyl-1-piperazinyl)-4-oxo-7-(trifluoromethyl)-3(4H)-quinazolinyl]ethoxy]phenyl]-5-methyl-. CAS No. 2573979-31-2. Molecular formula: C33H28ClF3N6O4S. Mole weight: 697.13. | |
| Eribulin | Eribulin suppressed centromere dynamics at concentrations that arrest mitosis. At 60 nmol/L eribulin (2 x mitotic IC(50)), the relaxation rate was suppressed 21%, the time spent paused increased 67%, and dynamicity decreased 35% (but without reduction in mean centromere separation), indicating that eribulin decreased normal microtubule-dependent spindle tension at the kinetochores, preventing the signal for mitotic checkpoint passage. [(3)H]eribulin binds soluble tubulin at a single site; however, this binding is complex with an overall K(d) of 46 microM, but also showing a real or apparent very high affinity (K(d) = 0.4 microM) for a subset of 25% of the tubulin. Eribulin also binds microtubules with a maximum stoichiometry of 14.7 +/- 1.3 molecules per microtubule (K(d) = 3.5 microM), strongly suggesting the presence of a relatively high-affinity binding site at microtubule ends. At 100 nM, the concentration that inhibits microtubule plus end growth by 50%, we found that one molecule of eribulin is bound per two microtubules, indicating that the binding of a single eribulin molecule at a microtubule end can potently inhibit its growth. Eribulin does not suppress dynamic instability at microtubule minus ends. Eribulin's in vivo superiority derives from its ability to induce irreversible mitotic blockade, which appears related to persistent drug retention and sustained Bcl-2 phosphorylation. Synonyms: Halaven; B1939; E7389; ER-0 | |
| Etoposide, 95.0-105.0% (HPLC) USP | Potent anti-cancer compound. Induces apoptosis in normal and tumor cell lines. DNA Topoisomerase II activity inhibitor. Increases Topo II-mediated DNA breakage primarily by inhibiting the ability of the enzyme to religate cleaved nucleic acid molecules. Does not lead to immediate block of DNS synthesis, induces a progressive inhibition of DNA replication. p53 activator. Blocks the cell cycle between the end of the S phase and the early G2 phase. Oncoprotein Mdm2 synthesis inhibitor. Apoptosis inducer through the cytochrome c/Apaf-1/caspase-9 pathway and the Fas-mediated death signaling pathway. Cell cycle checkpoint activator. Affects gene expression at different levels (chromatin remodeling, transcrip- tion and alternative splicing). Chemotherapeutic compound used in cancers. Used in conditioning regimen prior to a bone marrow or blood stem cell transplantation. Highly effective in mobilizing stem cells. Group: Biochemicals. Alternative Names: 4-Des methyl epipodophyllotoxin; VP-16-213, NSC 141540. Grades: USP. CAS No. 33419-42-0. Pack Sizes: 250mg, 1g, 5g, 25g. US Biological Life Sciences. | Worldwide |
| FEN1-IN-1 | FEN1-IN-1 (compound 1) is a small molecule flap endonuclease 1 (FEN1) inhibitor with antitumor activity. FEN1-IN-1 binds to the active site of FEN1 and partly achieves inhibition by the co-ordination of Mg2+ ions. FEN1-IN-1 initiaties a DNA damage response and activates the ATM checkpoint signalling pathway, the phosphorylation of histone H2AX and the ubiquitination of FANCD2 in mammalian cells. FEN1-IN-1 is promising for research of cancers[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 824983-91-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-123834. | |
| Fianlimab | Fianlimab (REGN3767) is a human monoclonal antibody that targets the immune checkpoint receptor LAG-3 on T cells and has anti-tumour activity [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: REGN3767. CAS No. 2126132-98-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99617. | |
| Filanesib | Filanesib, also known as ARRY-520, is a synthetic, small molecule targeting the kinesin spindle protein (KSP) with potential antineoplastic activity. KSP inhibitor ARRY-520 specifically inhibits KSP (kinesin-5 or Eg5), resulting in activation of the spindle assembly checkpoint, induction of cell cycle arrest during the mitotic phase, and consequently cell death in tumor cells that are actively dividing. Synonyms: ARRY-520; ARRY 520; ARRY520. Grade: 0.98. CAS No. 885060-09-3. Molecular formula: C20H22F2N4O2S. Mole weight: 420.479. | |
| Floxuridine | Floxuridine (5-Fluorouracil 2'-deoxyriboside) is a pyrimidine analog and known as an oncology antimetabolite. Floxuridine inhibits Poly(ADP-Ribose) polymerase and induces DNA damage by activating the ATM and ATR checkpoint signaling pathways in vitro. Floxuridine is a extreamly potent inhibitor for S. aureus infection and induces cell apoptosis [1] [2]. Floxuridine has antiviral effects against HSV and CMV [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 5-Fluorouracil 2'-deoxyriboside. CAS No. 50-91-9. Pack Sizes: 10 mM * 1 mL; 100 mg; 200 mg; 500 mg. Product ID: HY-B0097. | |
| Floxuridine | Floxuridine (5-Fluorouracil 2'-deoxyriboside) is a pyrimidine analog and known as an oncology antimetabolite. Floxuridine inhibits Poly(ADP-Ribose) polymerase and induces DNA damage by activating the ATM and ATR checkpoint signaling pathways in vitro. Floxuridine is a extreamly potent inhibitor for S. aureus infection and induces cell apoptosis. Floxuridine has antiviral effects against HSV and CMV. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 1-beta-d-2'-deoxyribofuranosyl-5-flurouracil;1beta-D-2-Deoxyribofuranosyl-5-fluorouracil;2'-deoxy-5-fluoro-uridin;5-fluor-1-(beta-2'-deoxyribofuranosyl)pyrimidin-2,4(1h,3h)-dion;5-Fluor-1-(beta-2-deoxyribofuranosyl)pyrimidin-2,4(1H,3H)-dion;5-Fluoro-2-deoxyiridine;5-Fluorouracil 2-deoxyriboside;5-Fluorouracil deoxyriboside. Product Category: Inhibitors. CAS No. 50-91-9. Molecular formula: C9H11FN2O5. Mole weight: 246.19. Purity: 0.9995. Product ID: ACM50919. Alfa Chemistry ISO 9001:2015 Certified. | |
| Ganciclovir | Ganciclovir (GCV) is a pro-drug nucleoside analog that is activated by phosphorylation. It is useful in the study of gene therapy in cancer research. Upon expression of a viral suicide gene encoding thymidine kinase, the non-toxic pro-drug is converted to a phosphorylated active analog and is incorporated into the DNA of replicating eukaryotic cells, causing death of the malignant dividing cell. The cell cycle is irreversibly arrested at the G2-M checkpoint. Gap junction involvement in the ganciclovir bystander effect has been studied. Ganciclovir has been used to study loss of telomeres and to evaluate sensitivity of viruses to antiviral treatments. Ganciclovir is used in molecular biology for selection against random recombination events when homologous recombination of a gene of interest is required. Group: Biochemicals. Alternative Names: 2-Amino-1, 9-dihydro-9-[[2-hydroxy-1- (hydroxymethyl) ethoxy]methyl]-6H-purin-6-one; 2-NDG; 2-Nor-2-deoxyguanosine; 9-(1,3-Dihydroxy-2-propoxymethyl)guanine; BW 759; BW 759U; BW-B 759U; Biolf 62; DHPG; Denosine; Gancyclovir; Ganguard; Ganquard; HHEMG; Hydroxyacyclovir; Natclovir; RS 21592; Vitrasert. Grades: Highly Purified. CAS No. 82410-32-0. Pack Sizes: 100mg, 500mg, 1g, 5g. Molecular Formula: C?H??N?O?, Molecular Weight: 255.23. US Biological Life Sciences. | Worldwide |
| Gartisertib | Gartisertib (VX-803) is an ATP-competitive, orally active, and selective ATR inhibitor, with a Ki of <150 pM. Gartisertib potently inhibits ATR-driven phosphorylated checkpoint kinase-1 (Chk1) phosphorylation with an IC50 of 8 nM. Antitumor activity[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: VX-803; M4344; ATR inhibitor 2. CAS No. 1613191-99-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136270. | |
| GDC-0425 | This active molecular is an selective Checkpoint kinase 1 (Chk1) inhibitors and it enhances gemcitabine efficacy in tumor xenograft models. GDC-0425 was safe and yielded responses in patients with a variety of cancers. In Oct 2013, GDC 0425 was in phase I trials for Solid tumours and Lymphoma (late-stage disease) in USA and France. In May 2014, Genentech completed a phase I trial in Lymphoma and Solid tumours (late-stage disease) in USA and France. Uses: Solid tumours and lymphoma. Synonyms: GDC-0425; GDC 0425; GDC0425; 5-((1-ethylpiperidin-4-yl)oxy)-9H-pyrrolo[2,3-b:5,4-c']dipyridine-6-carbonitrile; RG-7602; RG 7602; RG7602. Grade: 98%. CAS No. 1200129-48-1. Molecular formula: C18H19N5O. Mole weight: 321.38. | |
| GDC-0575 freebase | GDC-0575, also known as ARRY-575 and RG7741, is a potent and selective inhibitor of cell cycle checkpoint kinase 1 (Chk1) with an IC50 of 1.2?nM. Chk1 inhibitor GDC-0575 specifically binds to and inhibits Chk1; this may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases, which permits the cells to undergo DNA repair prior to entry into mitosis. Uses: Designed for use in research and industrial production. Additional or Alternative Names: GDC-0575; GDC 0575; GDC0575; ARRY-575; ARRY-575; ARRY575; RG7741; RG-7741; RG 7741; AK 687476; AK-687476; AK687476; GDC-0575 HCl; GDC-0575 hydrochloride. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1196541-47-5. Molecular formula: C16H20BrN5O. Mole weight: 378.27. Purity: >98%. IUPACName: (R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide. Canonical SMILES: O=C(C1CC1)NC2=CNC3=NC=C(Br)C(N4C[C@H](N)CCC4)=C32. Product ID: ACM1196541475. Alfa Chemistry ISO 9001:2015 Certified. | |
| GDC0575 monohydrochloride | GDC0575 is a potent and selective inhibitor of cell cycle checkpoint kinase 1 (Chk1) with an IC50 of 1.2?nM. Synonyms: GDC0575 hydrochloride; ARRY-575 hydrochloride; (R)-N-(4-(3-Aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide hydrochloride. Grade: 95%. CAS No. 1196504-54-7. Molecular formula: C16H21BrClN5O. Mole weight: 414.73. | |
| GSK-1070916A | GSK-1070916A is an ATP-competitive inhibitor of the serine/threonine kinases Aurora B and C with potential antineoplastic activity. Aurora B/C kinase inhibitor GSK1070916A binds to and inhibits the activity of Aurora kinases B and C, which may result in inhibition of cellular division and a decrease in the proliferation of tumor cells that overexpress the Aurora kinases B and C. Aurora kinases play essential roles in mitotic checkpoint control during mitosis, and are overexpressed by a wide variety of cancer cell types. Synonyms: GSK 1070916; GSK-1070916; GSK 1070916; GSK1070916A; GSK 1070916A; NMI-900; NMI 900; NMI900; N'-[4-[4-[2-[3-[(Dimethylamino)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-ethyl-1H-pyrazol-3-yl]phenyl]-N,N-dimethylurea. Grade: 98%. CAS No. 942918-07-2. Molecular formula: C30H33N7O. Mole weight: 507.63. | |
| Hymenialdisine | A potent inhibitor of a variety of kinases including MEK-1, GSK-3B, and CKI. It also exhibits inhibition of the G2 cell cycle checkpoint at the micromolar concentrations. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Indibulin | Indibulin (ZIO 301), an orally applicable inhibitor of tubulin assembly, shows potent anticancer activity with a minimal neurotoxicity. Indibulin reduces inter-kinetochoric tension, produces aberrant spindles, activates mitotic checkpoint proteins Mad2 and BubR1, and induces mitotic arrest and apoptosis [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ZIO 301; D 24851. CAS No. 204205-90-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13649. | |
| Indoximod | A methylated tryptophan with immune checkpoint inhibitory activity. Indoximod inhibits the enzyme indoleamine 2,3-dioxygenase (IDO), which degrades the essential amino acid tryptophan, and may increase or maintain tryptophan levels important to T cell function. Tryptophan depletion is associated with immunosuppression involving T cell arrest and anergy. Synonyms: NLG8189; NLG 8189; NLG-8189; D-1MT; 1-methyl-D-tryptophan; H-D-Trp(Me)-OH. Grade: > 98%. CAS No. 110117-83-4. Molecular formula: C12H14N2O2. Mole weight: 218.25. | |
| KIF18A-IN-1 | KIF18A-IN-1 is an inhibitor of the mitotic kinesin KIF18A with anti-tumor activity. KIF18A targeted inhibitors may activate mitotic checkpoints and selectively kill chromosomally unstable cancer cells[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2600559-12-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145034. | |
| Malformin A1 | Peptide antibiotic. Antibcaterial. Plant growth stimulator. Induces root curvature and malformation in plants. Mycotoxin. Prevents interleukin-1 (IL-1) induced endothelial changes by inhibition of protein synthesis. Inhibitor of interleukin-1 beta (IL1 beta) binding to its receptor. Enhancer of cellular fibrinolytic activity. Disrupts the cell cycle at the G2 checkpoint of cancer cells, leading to sensitization of the cancer cells to anti-cancer reagents. Anticancer compound. Cytotoxic against several cancer cell lines. Antimalarial and antitrypanosomal. Inhibitor of BRAF-mutated melanoma cell lines. Group: Biochemicals. Grades: Highly Purified. CAS No. 3022-92-2. Pack Sizes: 250ug, 1mg. Molecular Formula: C??H??N?O?S?. US Biological Life Sciences. | Worldwide |
| Malformin C | Peptide antibiotic. Induces root curvature and malformation in plants. Antibacterial, antimalarial and antitrypanosomal. Disrupts the cell cycle at the G2 checkpoint of cancer cells, leading to sensitization of the cancer cells to anti-cancer reagents.Malformin C is a bicyclic pentapeptide containing L-leucine, D-isoleucine, L-valine, and two D-cysteines coupled with a disulfide-bond bridge. Malformins A1 and C, originally isolated from the culture broth of Aspergillus niger FKI-2342, were found to abrogate the bleomycin-induced G2 arrest in Jurkat cells with IC50 values of 480nM and 0.9nM, respectively. Malformins may be promising candidates as anti-cancer agents. Source:Synthetic. Originally isolated from Aspergillus niger FKI-2342. Group: Biochemicals. Grades: Highly Purified. CAS No. 59926-78-2. Pack Sizes: 250ug, 1mg. Molecular Formula: C23H39N5O5S2. US Biological Life Sciences. | Worldwide |
| Mirin | Mirin is a potent Mre11-Rad50-Nbs1 (MRN) complex inhibitor. Mirin prevents MRN-dependent activation of ATM (IC 50 =12 μM) without affecting ATM protein kinase activity, and it inhibits Mre11-associated exonuclease activity. Mirin abolishes the G2/M checkpoint and homology-dependent repair in mammalian cells. Mirin prevents ATM activation in response to DNA double-strand breaks (DSBs) and blocks homology-directed repair (HDR) in mammalian cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 299953-00-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-117693. | |
| Mirin | Mirin is a potent Mre11-Rad50-Nbs1 (MRN) complex inhibitor. Mirin prevents MRN-dependent activation of ATM (IC50=12 ?M) without affecting ATM protein kinase activity, and it inhibits Mre11-associated exonuclease activity. Mirin abolishes the G2/M checkpoint and homology-dependent repair in mammalian cells. Mirin prevents ATM activation in response to DNA double-strand breaks (DSBs) and blocks homology-directed repair (HDR) in mammalian cells[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1198097-97-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-19959. | |
| Monalizumab | Monalizumab (IPH2201) is an immune checkpoint inhibitor targeting Natural Killer Group 2A ( NKG2A ). Monalizumab, a humanized anti-NKG2A blocking mAb, increases IFN-γ production, thereby promoting NK cell effector functions. Monalizumab can be used for the research of head and neck squamous cell carcinoma (HNSCC) [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: IPH2201. CAS No. 1228763-95-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P99032. | |
| MPS1 Inhibitor, NMS-P715 ( (N- (2, 6-diethylphenyl) -1-methyl-8- ({4-[ (1-methylpiperidin-4-yl) carbamoyl]-2- (trifluoromethoxy) phenyl}amino) -4, 5-dihydro-1H-pyrazolo[4, 3-h]quinazoline-3-carboxamide) ) | An orally bioavailable, ATP-competitive, pyrazolo-quinazoline, MPS1 inhibitor (IC50=182nM, Ki=0.99nM) that is shown to act in a reversible and time-dependent manner. It demonstrates selectivity for MPS1 against a panel of 60 kinases, displaying activity against only three kinases, CK2, MELK, and NEK6 (<10uM), but not against other mitotic kinases including PLK1, CDK1, Aurora A, Aurora B, or the SAC kinase BUB1, in an in vitro kinase assay. It promotes massive SAC (spindle assembly checkpoint) override (EC50=65nM) in nocodazole-arrested U20S cells and elicits a reduction in the G1 and G2/M phase of the cell cycle in A2780 ovarian cancer cells, similar to RNAi-mediated MPS1 silencing. In addition, it is shown to inactivate SAC, delocalize kinetochore components, and inhibit the proliferation of select cancer cell lines (IC50 ~1uM), without marked activity among a panel of 127 normal cell lines. Also, it inhibits A2780 tumor xenograft growth in mice (90mg/kg/day, o.s., in vivo) by 53% wit Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| N-Desmethyl Dovitinib | Dovitinib derivative; a benzimidazole quinolinone for inhibiting a checkpoint kinase 1 and its use in combination therapy for cancer. Group: Biochemicals. Alternative Names: 4-Amino-5-fluoro-3-[6-(1-piperazinyl)-1H-benzimidazol-2-yl]-. Grades: Highly Purified. CAS No. 668432-44-8. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Neihulizumab | Neihulizumab (ALTB-168) is an immune checkpoint agonistic antibody that binds to human CD162 (PSGL-1) , leading to downregulation of activated T-cells. Neihulizumab can be uesd for steroid-refractory acute graft-versus-host-disease (SR-aGVHD), psoriasis, psoriatic arthritis and ulcerative colitis research [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: ALTB-168; Anti-PSGL1/CD162 Reference Antibody (neihulizumab). CAS No. 2158362-38-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99378. | |
| PD 407824 | PD 407824 is a checkpoint kinase Chk1 and WEE1 inhibitor with IC50s of 47 and 97 nM, respectively. PD 407824 is a chemical BMP sensitizer and increases the sensitivity of cells to sub-threshold amounts of BMP4[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 622864-54-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18961. | |
| PF 477736 | Selective checkpoint kinase 1 (Chk1) inhibitor (Ki values are 0.49 and 47 nM for Chk1 and Chk2 respectively). Abrogates cell cycle arrest at S and G2-M checkpoints; sensitizes cells to DNA damage. Group: Biochemicals. Grades: Highly Purified. CAS No. 952021-60-2. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences. | Worldwide |
| Prexasertib | Prexasertib (LY2606368) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a K i of 0.9 nM and an IC 50 of <1 nM. Prexasertib inhibits CHK2 (IC 50 =8 nM) and RSK1 (IC 50 =9 nM). Prexasertib causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib shows potent anti-tumor activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY2606368. CAS No. 1234015-52-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18174. | |
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