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Product | Description | |
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Checkpoint Protein Hus1 (213-232) (human) Quick inquiry Where to buy Suppliers range | HDAC1 plays an important role in regulating eukaryotic chromatin structure and specifically interacts with human Hus1 gene products in yeast, mammalian cells, and in vitro. S. Pombe's Hus1 protein is associated with G2/M checkpoint control and is a member of the cell cycle checkpoint Rad protein, which is involved in the mitotic checkpoint induced by DNA damage or DNA replication arrest. Synonyms: H-Leu-Ala-Ser-Glu-Ser-Thr-His-Glu-Asp-Arg-Asn-Val-Glu-His-Met-Ala-Glu-Val-His-Ile-OH. Grades: ≥95%. Molecular formula: C95H150N30O35S. Mole weight: 2304.48. | |
10Z-Hymenialdisine Quick inquiry Where to buy Suppliers range | Insecticidal and cytotoxic. Potent NF-kappaB inhibitor. Inhibits various pro-inflammatory cytokines such as IL-1, IL-2, IL-6, IL-8, TNF-alpha and nitric oxide (NO) in a variety of cell lines. ATP-competitive kinase inhibitor. Inhibits DNA damage checkpoint at G2, cyclin-dependent kinases CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, CDK5/p25, GSK-3beta and casein kinase 1 (CK1). Potent mitogen-activated protein kinase kinase-1 (MEK-1) inhibitor. MARK (microtubule affinity-regulating kinase) inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 82005-12-7. Pack Sizes: 500ug, 1mg. Molecular Formula: C??H??BrN?O?, Method for Determining. US Biological Life Sciences. | Worldwide |
10Z-Hymenialdisine (Hymenialdisine, 4-(2-Amino-4-oxo-2-imidazolidin-5-ylidene)-2-bromo-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8-one) Quick inquiry Where to buy Suppliers range | Isolated from sponge Axinella carteri. A potent inhibitor of mitogen-activated protein kinase kinase-1 (MEK-1) (IC50=6nm). Blocks the in vivo phosphorylation of the microtubule-binding protein tau at sites that are hyperphosphorylated by glycogen synthase kinase-b (GSK-3b) and CDK5/p35 in Alzheimers disease. Inhibitor of DNA damage checkpoint at G2 phase (IC50=6uM), cyclin-dependent kinases CDK1/cyclin B (IC50=22nm), CDK2/cyclin A (IC50=70 nm), CDK2/cyclin E (IC50=40nm), CDK4/cyclin D1 (IC50 = 600nm), CDK5/p25 (IC50=28nm), GSK-3b (IC50=10nm), and casein kinase 1 (CK1) (IC50=35nm). Group: Biochemicals. Grades: Highly Purified. CAS No. 82005-12-7. Pack Sizes: 250ug, 1mg. US Biological Life Sciences. | Worldwide |
2-Bromothiazole-5-carboxaldehyde Quick inquiry Where to buy Suppliers range | 2-Bromothiazole-5-carboxaldehyde is a reactant in the preparation of thienopyridines as potent checkpoint 1 kinase (CHK1) inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 464192-28-7. Pack Sizes: 250mg, 500mg. Molecular Formula: C4H2BrNOS, Molecular Weight: 192.03. US Biological Life Sciences. | Worldwide |
2OH-BNPP1 Quick inquiry Where to buy Suppliers range | 2OH-BNPP1 is a novel inhibitor of checkpoint kinase BUB1. Group: Biochemicals. Grades: Highly Purified. CAS No. 833481-73-5. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C16H19N5O, Molecular Weight: 297.35. US Biological Life Sciences. | Worldwide |
2-Oxa-7-azaspiro[3.5]nonane Quick inquiry Where to buy Suppliers range | 2-Oxa-7-azaspiro[3.5]nonane is an intermediate used to prepare benzothienoazepine derivatives as potent respiratory syncytial virus RNA polymerase inhibitors. It is also used to prepare 1,7-Diazacarbazole derivatives as inhibitors of checkpoint kinase 1. Group: Biochemicals. Grades: Highly Purified. CAS No. 241820-91-7. Pack Sizes: 10mg, 50mg. Molecular Formula: C7H13NO, Molecular Weight: 127.18. US Biological Life Sciences. | Worldwide |
(2S,3S,4S,5S)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate Quick inquiry Where to buy Suppliers range | (2S,3S,4S,5S)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate is a potential drug candidate used in biomedicine for treating cancer. It is a small molecule inhibitor of WEE1, a protein kinase that regulates the G2/M checkpoint of the cell cycle. Inhibition of WEE1 leads to the activation of CDK1 and CDK2, causing DNA damage and cell death in cancer cells. Synonyms: (2S,3S,4S,5S)-5-(4-benzoylamino-2-oxopyrimidine-1(2H)-yl)-2-((benzoyloxy)methyl)-4-Fluoro-4-methyltetrahydrofuran-3-yl benzoate. Grades: 97%. Molecular formula: C31H26FN3O7. Mole weight: 571.55. | |
3,3'-Diindolylmethane Quick inquiry Where to buy Suppliers range | 3,3'-Diindolylmethane is an activator of checkpoint kinase 2 (Chk2) that induces G2/M cell cycle arrest in various cancer cell lines. It is used as an antineoplastic agent. Nutritional supplement in health care products. Synonyms: 1H-Indole, 3,3'-methylenebis-; 3,3'-Methylenebis[1H-indole]; Indole, 3,3'-methylenedi-; 3,3'-Bisindolylmethane; 3,3'-Methanediyldi(1H-indole); Arundine; Bis(1H-indol-3-yl)methane; Bis(3-indolyl)methane; Cervicon-DIM; Di(1H-indol-3-yl)methane; Diindolylmethane; DIM; DIM (AhR agonist); DIM (diindolylmethane); HB 236; Infemin. Grades: ≥99% by HPLC. CAS No. 1968-5-4. Molecular formula: C17H14N2. Mole weight: 246.31. | |
8-[(6-Amino)hexyl]-amino-adenosine-2',5'-bisphosphate - DYQ-661 Quick inquiry Where to buy Suppliers range | DYQ-661, a strikingly potent and exclusive inhibitor of CD73, a critical enzyme implicated in the biosynthesis of immunosuppressive adenosine in the tumor microenvironment, presents a hopeful alternative for patients with different types of cancer. The preclinical investigations depict handsome outcomes, enhancing the effectiveness of immune checkpoint inhibitors. DYQ-661 is an exceedingly promising therapeutic approach that demands significant attention in the realm of cancer treatment. Synonyms: 8-[(6-Amino)hexyl]-amino-adenosine-2',5'-bisphosphate, labeled with DYQ 661, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C55H70N9O18P2S2 (Anion). Mole weight: 1271.27 (Anion). | |
AHR Antagonist 5 Quick inquiry Where to buy Suppliers range | AHR Antagonist 5, an effective and orally active aromatic hydrocarbon receptor (AHR) antagonist with IC50 of less than 0.5 μM. It can significantly inhibit tumor growth in combination with the checkpoint inhibitor anti-PD-1. Synonyms: BCP33104; HY-136220; CS-0120848; (R)-N-(2-(5-Fluoropyridin-3-Yl)-8-Isopropylpyrazolo[1,5-A][1,3,5]Triazin-4-Yl)-2,3,4,9-Tetrahydro-1H-Carbazol-3-Amine Trihydrochloride. Grades: ≥98% by HPLC. CAS No. 2247953-39-3. Molecular formula: C25H27Cl3FN7. Mole weight: 550.9. | |
Alsevalimab Quick inquiry Where to buy Suppliers range | Alsevalimab is a human monoclonal antibody that targets B7-H4 with potential antineoplastic and immune checkpoint inhibitory activities. CAS No. 2254029-91-7. | |
AMG510 racemate Quick inquiry Where to buy Suppliers range | AMG510 is a potent KRAS G12C covalent inhibitor with potential antineoplastic activity. At the 2019 World Conference on Lung Cancer (WCLC), Amgen declared the efficacy of AMG510 for treating non-small cell lung cancer (NSCLC) with KRAS G12 C-mutated solid tumors. Amgen also announced prospective directions for AMG510 through academic scholars and reports the few limitations on official drug release as evidence for potential investors to consider the value of AMG510. Uses: Immune checkpoint inhibitors. Synonyms: AMG-510 racemate; AMG 510 racemate; Sotorasib racemate. CAS No. 2296729-00-3. Molecular formula: C30H30F2N6O3. Mole weight: 560.59. | |
ARRY-520 R enantiomer Quick inquiry Where to buy Suppliers range | ARRY-520 R enantiomer is the R form of ARRY-520, which is a synthetic, small molecule kinesin spindle protein (KSP) inhibitor. ARRY-520 had low nanomolar antiproliferative activity in tumor cell lines and specifically inhibits KSP (kinesin-5 or Eg5), resulting in activation of the spindle assembly checkpoint, induction of cell cycle arrest during the mitotic phase, and consequently cell death in tumor cells that are actively dividing. Synonyms: ARRY-520 R enantiomer; ARRY 520 R enantiomer; ARRY520 R enantiomer; 1,3,4-Thiadiazole-3(2H)-carboxamide, 2-(3-aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-, (2R)-. Grades: >98%. CAS No. 885060-08-2. Molecular formula: C20H22F2N4O2S. Mole weight: 420.48. | |
AZD0156 Quick inquiry Where to buy Suppliers range | AZD0156 is an orally active, potent and selective ataxia telangiectasia mutated (ATM) kinase inhibitor, used for cancer treatment. AZD0156 prevents DNA damage checkpoint activation, and disrupts DNA damage repair, inducing tumor cell apoptosis, and leading to cell death in ATM-overexpressing tumor cells. Uses: Protein kinase inhibitors. Synonyms: 8-[6-[3-(dimethylamino)propoxy]-3-pyridyl]-3-methyl-1-tetrahydropyran-4-yl-imidazo[4,5-c]quinolin-2-one; AZD0156; AZD-0156; AZD 0156. CAS No. 1821428-35-6. Molecular formula: C26H31N5O3. Mole weight: 461.56. | |
AZD-7762 Quick inquiry Where to buy Suppliers range | AZD-7762 is a synthetic small molecule inhibitor of checkpoint kinases (Chks) with potential chemosensitizing activity. AZD7762 binds to and inhibits Chks, which may prevent cell cycle arrest and subsequent nucleotide excision repair in DNA-damaged tumor cells, resulting in tumor cell apoptosis. Synonyms: AZD 7762; AZD7762. Grades: 0.98. CAS No. 860352-01-8. Molecular formula: C17H19FN4O2S. Mole weight: 362.423. | |
Besifloxacin Impurity G Quick inquiry Where to buy Suppliers range | Besifloxacin Impurity G is an intermediate used to prepare ureido thiophene carboxamides as checkpoint kinase inhibitors. It is also an impurity of Besifloxacin. Synonyms: (R)-3-Amino-hexahydroazepine; (R)-Azepan-3-amine; (R)-Hexahydro-1H-azepin-3-amine; (R)-3-Amino-Hexahydro-1H-Azepin; 1H-Azepin-3-amine, hexahydro-, (3R)-. Grades: > 95%. CAS No. 124932-43-0. Molecular formula: C6H14N2. Mole weight: 114.19. | |
Camrelizumab Quick inquiry Where to buy Suppliers range | Camrelizumab is an anti-PD-1 immune checkpoint inhibitor that is being investigated for hepatocellular carcinoma and Hodgkin lymphoma. Camrelizumab is a humanized anti-PD-1 IgG4 antibody that blocks the binding of PD-L1 and PD-L2 to PD-1 with immune checkpoint inhibitory and antineoplastic activities. Synonyms: SHR-1210. Grades: ≥98%. | |
CBP501 Quick inquiry Where to buy Suppliers range | CBP501 is a peptide with G2 checkpoint-abrogating activity. G2 checkpoint inhibitor CBP501 inhibits multiple serine/threonine kinases, including MAPKAP-K2, C-Tak1, and CHK1, that phosphorylate serine 216 of the dual-specific phosphatase Cdc25C (cell division checkpoint 25 C); disruption of Cdc25C activity results in the inhibition of Cdc25C dephosphorylation of the mitotic cyclin-dependent kinase complex Cdc2/cyclin B, preventing entry into the mitotic phase of the cell cycle. Check for active clinical trials or closed clinical trials using this agent. Synonyms: CBP-501; CBP 501; H-D-Bpa-D-Ser-D-Trp-D-Ser-D-Phe(F5)-D-Cha-D-Arg-D-Arg-D-Arg-D-Gln-D-Arg-D-Arg-OH. CAS No. 565434-85-7. Molecular formula: C86H122F5N29O17. Mole weight: 1929.06. | |
CBP-93872 Quick inquiry Where to buy Suppliers range | CBP-93872 is a G2 checkpoint inhibitor. CBP-93872 specifically abrogates the DNA double-stranded break (DSB)-induced G2 checkpoint through inhibiting maintenance. CBP-93872 is an inhibitor of maintenance of the DSB-specific G2 checkpoint and thus might be a strong candidate as the basis for a drug that specifically sensitizes p53-mutated cancer cells to DSB-inducing DNA damage therapy. Synonyms: CBP 93872; CBP93872; 1-amino-3-((2-bromo-4-methylphenyl)amino)propan-2-ol. Grades: 98%. CAS No. 67427-51-4. Molecular formula: C10H15BrN2O. Mole weight: 259.14. | |
Chk2 Inhibitor Quick inquiry Where to buy Suppliers range | Chk2 inhibitor is an inhibitor of checkpoint kinase 2 (Chk2; IC50 = 13.5 nM). Chk2 inhibitor enhances survival of 184B5, but not MDA-MB-231, cells following ionizing radiation and inhibits cell cycle arrest at the G2 stage induced by ionizing radiation in 184B5 cells. It also inhibits the production of IL-2 in Jurkat cells, the production of TNF-α in LPS-stimulated THP-1 cells and the growth of CEM leukemia T cells. Synonyms: SC-203885; (5Z)-5-(2-amino-1,5-dihydro-5-oxo-4H-imidazol-4-ylidene)-3,4,5,10-tetrahydro-azepino[3,4-b]indol-1(2H)-one; Hymenialdisine Analogue 1. CAS No. 724708-21-8. Molecular formula: C15H13N5O2. Mole weight: 295.3. | |
CTLA-4 inhibitor Quick inquiry Where to buy Suppliers range | CTLA-4 inhibitor is an inhibitor of CTLA-4, an immune checkpoint negatively regulating T cell function. CTLA-4 is thought to regulate T-cell proliferation early in an immune response, primarily in lymph nodes. Synonyms: MDK24720; MDK 24720; MDK-24720; CTLA-4 inhibitor. 2-(4-Fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one; EX-A913. CAS No. 635324-72-0. Molecular formula: C21H13F4N5O. Mole weight: 427.363. | |
Debromohymenialdisine Quick inquiry Where to buy Suppliers range | Protein kinase C (PKC) inhibitor. Inhibits the ATP binding site. Cytotoxic and insecticidal. G2 DNA damage checkpoint inhibitor. Check point kinases 1 (Chk1) and 2 (Chk2) inhibitor. Does not inhibit ataxia-telangiectasia mutated (ATM) or ATM-Rad3-related proteins. MAP kinase kinase 1 (MEK-1) inhibitor. Interleukin-1 (IL-1) inhibitor. Anti-osteoarthritic. Potential anti-Alzheimer agent. Group: Biochemicals. Grades: Highly Purified. CAS No. 75593-17-8, 125118-55-0. Pack Sizes: 100ug. Molecular Formula: C11H11N5O2. US Biological Life Sciences. | Worldwide |
Eribulin Quick inquiry Where to buy Suppliers range | Eribulin suppressed centromere dynamics at concentrations that arrest mitosis. At 60 nmol/L eribulin (2 x mitotic IC(50)), the relaxation rate was suppressed 21%, the time spent paused increased 67%, and dynamicity decreased 35% (but without reduction in mean centromere separation), indicating that eribulin decreased normal microtubule-dependent spindle tension at the kinetochores, preventing the signal for mitotic checkpoint passage. [(3)H]eribulin binds soluble tubulin at a single site; however, this binding is complex with an overall K(d) of 46 microM, but also showing a real or apparent very high affinity (K(d) = 0.4 microM) for a subset of 25% of the tubulin. Eribulin also binds microtubules with a maximum stoichiometry of 14.7 +/- 1.3 molecules per microtubule (K(d) = 3.5 microM), strongly suggesting the presence of a relatively high-affinity binding site at microtubule ends. At 100 nM, the concentration that inhibits microtubule plus end growth by 50%, we found that one molecule of eribulin is bound per two microtubules, indicating that the binding of a single eribulin molecule at a microtubule end can potently inhibit its growth. Eribulin does not suppress dynamic instability at microtubule minus ends. Eribulin's in vivo superiority derives from its ability to induce irreversible mitotic blockade, which appears related to persistent drug retention and sustained Bcl-2 phosphorylation. Synonyms: Halaven; B1939; E7389; ER-086526. Grades: >98%. CAS No. 253128-41-5. Molecular formula: C40H59NO11. Mole weight: 729.9. | |
Etoposide, 95.0-105.0% (HPLC) USP Quick inquiry Where to buy Suppliers range | Potent anti-cancer compound. Induces apoptosis in normal and tumor cell lines. DNA Topoisomerase II activity inhibitor. Increases Topo II-mediated DNA breakage primarily by inhibiting the ability of the enzyme to religate cleaved nucleic acid molecules. Does not lead to immediate block of DNS synthesis, induces a progressive inhibition of DNA replication. p53 activator. Blocks the cell cycle between the end of the S phase and the early G2 phase. Oncoprotein Mdm2 synthesis inhibitor. Apoptosis inducer through the cytochrome c/Apaf-1/caspase-9 pathway and the Fas-mediated death signaling pathway. Cell cycle checkpoint activator. Affects gene expression at different levels (chromatin remodeling, transcrip- tion and alternative splicing). Chemotherapeutic compound used in cancers. Used in conditioning regimen prior to a bone marrow or blood stem cell transplantation. Highly effective in mobilizing stem cells. Group: Biochemicals. Alternative Names: 4-Des methyl epipodophyllotoxin; VP-16-213, NSC 141540. Grades: USP. CAS No. 33419-42-0. Pack Sizes: 250mg, 1g, 5g, 25g. US Biological Life Sciences. | Worldwide |
Filanesib Quick inquiry Where to buy Suppliers range | Filanesib, also known as ARRY-520, is a synthetic, small molecule targeting the kinesin spindle protein (KSP) with potential antineoplastic activity. KSP inhibitor ARRY-520 specifically inhibits KSP (kinesin-5 or Eg5), resulting in activation of the spindle assembly checkpoint, induction of cell cycle arrest during the mitotic phase, and consequently cell death in tumor cells that are actively dividing. Synonyms: ARRY-520; ARRY 520; ARRY520. Grades: 0.98. CAS No. 885060-09-3. Molecular formula: C20H22F2N4O2S. Mole weight: 420.479. | |
Ganciclovir Quick inquiry Where to buy Suppliers range | Ganciclovir (GCV) is a pro-drug nucleoside analog that is activated by phosphorylation. It is useful in the study of gene therapy in cancer research. Upon expression of a viral suicide gene encoding thymidine kinase, the non-toxic pro-drug is converted to a phosphorylated active analog and is incorporated into the DNA of replicating eukaryotic cells, causing death of the malignant dividing cell. The cell cycle is irreversibly arrested at the G2-M checkpoint. Gap junction involvement in the ganciclovir bystander effect has been studied. Ganciclovir has been used to study loss of telomeres and to evaluate sensitivity of viruses to antiviral treatments. Ganciclovir is used in molecular biology for selection against random recombination events when homologous recombination of a gene of interest is required. Group: Biochemicals. Alternative Names: 2-Amino-1, 9-dihydro-9-[[2-hydroxy-1- (hydroxymethyl) ethoxy]methyl]-6H-purin-6-one; 2-NDG; 2-Nor-2-deoxyguanosine; 9-(1,3-Dihydroxy-2-propoxymethyl)guanine; BW 759; BW 759U; BW-B 759U; Biolf 62; DHPG; Denosine; Gancyclovir; Ganguard; Ganquard; HHEMG; Hydroxyacyclovir; Natclovir; RS 21592; Vitrasert. Grades: Highly Purified. CAS No. 82410-32-0. Pack Sizes: 100mg, 500mg, 1g, 5g. Molecular Formula: C?H??N?O?, Molecular Weight: 255.23. US Biological Life Sciences. | Worldwide |
GDC-0425 Quick inquiry Where to buy Suppliers range | This active molecular is an selective Checkpoint kinase 1 (Chk1) inhibitors and it enhances gemcitabine efficacy in tumor xenograft models. GDC-0425 was safe and yielded responses in patients with a variety of cancers. In Oct 2013, GDC 0425 was in phase I trials for Solid tumours and Lymphoma (late-stage disease) in USA and France. In May 2014, Genentech completed a phase I trial in Lymphoma and Solid tumours (late-stage disease) in USA and France. Uses: Solid tumours and lymphoma. Synonyms: GDC-0425; GDC 0425; GDC0425; 5-((1-ethylpiperidin-4-yl)oxy)-9H-pyrrolo[2,3-b:5,4-c']dipyridine-6-carbonitrile;RG-7602; RG 7602; RG7602. Grades: 98%. CAS No. 1200129-48-1. Molecular formula: C18H19N5O. Mole weight: 321.38. | |
GSK-1070916A Quick inquiry Where to buy Suppliers range | GSK-1070916A is an ATP-competitive inhibitor of the serine/threonine kinases Aurora B and C with potential antineoplastic activity. Aurora B/C kinase inhibitor GSK1070916A binds to and inhibits the activity of Aurora kinases B and C, which may result in inhibition of cellular division and a decrease in the proliferation of tumor cells that overexpress the Aurora kinases B and C. Aurora kinases play essential roles in mitotic checkpoint control during mitosis, and are overexpressed by a wide variety of cancer cell types. Synonyms: GSK 1070916; GSK-1070916; GSK 1070916; GSK1070916A; GSK-1070916A; GSK 1070916A; NMI-900; NMI 900; NMI900. CAS No. 942918-07-2. Molecular formula: C30H33N7O. Mole weight: 507.63. | |
Hymenialdisine Quick inquiry Where to buy Suppliers range | A potent inhibitor of a variety of kinases including MEK-1, GSK-3B, and CKI. It also exhibits inhibition of the G2 cell cycle checkpoint at the micromolar concentrations. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
Indoximod Quick inquiry Where to buy Suppliers range | A methylated tryptophan with immune checkpoint inhibitory activity. Indoximod inhibits the enzyme indoleamine 2,3-dioxygenase (IDO), which degrades the essential amino acid tryptophan, and may increase or maintain tryptophan levels important to T cell function. Tryptophan depletion is associated with immunosuppression involving T cell arrest and anergy. Synonyms: NLG8189; NLG 8189; NLG-8189; D-1MT; 1-methyl-D-tryptophan; H-D-Trp(Me)-OH. Grades: > 98%. CAS No. 110117-83-4. Molecular formula: C12H14N2O2. Mole weight: 218.25. | |
JH295 Quick inquiry Where to buy Suppliers range | JH295 is an irreversible, cysteine-targeted inhibitor of the human centrosomal kinase, Nek2. JH295 irreversibly inhibited cellular Nek2 without affecting the mitotic kinases, Cdk1, Aurora B, or Plk1. Moreover, JH295 did not perturb bipolar spindle assembly or the spindle assembly checkpoint. To our knowledge, JH295 is the first small molecule shown to inactivate Nek2 kinase activity in cells. Synonyms: JH 295; JH-295; 3-[(2-Ethyl-4-methyl-1H-imidazole)-5-ylmethylene]-5-[(1-oxo-2-propynyl)amino]-1H-indole-2(3H)-one. CAS No. 1311143-71-1. Molecular formula: C18H16N4O2. Mole weight: 320.35. | |
K-858 Quick inquiry Where to buy Suppliers range | K-858 is a novel inhibitor of mitotic kinesin Eg5 and antitumor agent, induces cell death in cancer cells. K858 blocked centrosome separation, activated the spindle checkpoint, and induced mitotic arrest in cells accompanied by the formation of monopolar spindles. Synonyms: K-858; K 858; K858. Grades: 98%. CAS No. 72926-24-0. Molecular formula: C13H15N3O2S. Mole weight: 277.34. | |
Lirilumab Quick inquiry Where to buy Suppliers range | A fully humanized monoclonal antibody against killer-cell immunoglobulin-like receptors (KIR), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, lirilumab binds to KIR, thereby preventing the binding of KIR ligands to KIR on natural killer (NK) cells. By blocking these inhibitory receptors, NK cells become activated and attack cancer cells leading to tumor cell death. KIR, a member of the immunoglobulin superfamily, is expressed on the surface of NK cells. Synonyms: Anti-KIR (1-7F9); Anti-KIR monoclonal antibody - Innate Pharma; BMS-986015; BMS 986015; BMS986015; IPH-21; IPH 21; IPH21; IPH-2101; IPH2102; IPH 2102;LIRI; NN 1975; NN1975; NN-1975. CAS No. 1000676-41-4. | |
LY2606368 dihydrochloride Quick inquiry Where to buy Suppliers range | The dihydrochloride salt form of LY2606368 which also known as prexasertib, is an inhibitor of checkpoint kinase 1 and has potential effect in antineoplastic. It is still under Phase II clinical trial against breast cancer and some other sorts of cancers. Uses: The dihydrochloride salt form of ly2606368 which also known as prexasertib, is an inhibitor of checkpoint kinase 1 and has potential effect in antineoplastic. Synonyms: UNII-9RFT476U2L; 9RFT476U2L; LY2606368 (dihydrochloride); 1234015-54-3; HY-18174A; CS-3507; CS 3507; CS3507; LY2606368; LY 2606368; LY-2606368. Grades: 98%. CAS No. 1234015-54-3. Molecular formula: C18H21Cl2N7O2. Mole weight: 438.31. | |
Malformin A1 Quick inquiry Where to buy Suppliers range | Peptide antibiotic. Antibcaterial. Plant growth stimulator. Induces root curvature and malformation in plants. Mycotoxin. Prevents interleukin-1 (IL-1) induced endothelial changes by inhibition of protein synthesis. Inhibitor of interleukin-1 beta (IL1 beta) binding to its receptor. Enhancer of cellular fibrinolytic activity. Disrupts the cell cycle at the G2 checkpoint of cancer cells, leading to sensitization of the cancer cells to anti-cancer reagents. Anticancer compound. Cytotoxic against several cancer cell lines. Antimalarial and antitrypanosomal. Inhibitor of BRAF-mutated melanoma cell lines. Group: Biochemicals. Grades: Highly Purified. CAS No. 3022-92-2. Pack Sizes: 250ug, 1mg. Molecular Formula: C??H??N?O?S?. US Biological Life Sciences. | Worldwide |
Malformin C Quick inquiry Where to buy Suppliers range | Peptide antibiotic. Induces root curvature and malformation in plants. Antibacterial, antimalarial and antitrypanosomal. Disrupts the cell cycle at the G2 checkpoint of cancer cells, leading to sensitization of the cancer cells to anti-cancer reagents.Malformin C is a bicyclic pentapeptide containing L-leucine, D-isoleucine, L-valine, and two D-cysteines coupled with a disulfide-bond bridge. Malformins A1 and C, originally isolated from the culture broth of Aspergillus niger FKI-2342, were found to abrogate the bleomycin-induced G2 arrest in Jurkat cells with IC50 values of 480nM and 0.9nM, respectively. Malformins may be promising candidates as anti-cancer agents. Source:Synthetic. Originally isolated from Aspergillus niger FKI-2342. Group: Biochemicals. Grades: Highly Purified. CAS No. 59926-78-2. Pack Sizes: 250ug, 1mg. Molecular Formula: C23H39N5O5S2. US Biological Life Sciences. | Worldwide |
MEDI0680 Quick inquiry Where to buy Suppliers range | A humanized immunoglobulin (Ig) G4 monoclonal antibody directed against the negative immunoregulatory human cell surface receptor programmed cell death 1 (PD-1), a transmembrane protein in the Ig superfamily expressed on T cells. MEDI0680 has potential immune checkpoint inhibitory and antineoplastic activities because it binds to and inhibits PD-1 and its downstream signaling pathways. Synonyms: AMP-514; AMP 514; AMP514; MEDI 0680; MEDI-0680; MEDI0680. | |
Mirin Quick inquiry Where to buy Suppliers range | Mirin is an MRN-ATM pathway inhibitor, inhibiting MRN-dependent activation of ATM without affecting ATM protein kinase activity and Mre11-associated exonuclease activity. Mirin also inhibits the G2/M checkpoint and homology-dependent repair in mammalian cells. Synonyms: 2-amino-5-[(4-hydroxyphenyl)methylidene]-1,3-thiazol-4-one. Grades: ≥95%. CAS No. 299953-00-7. Molecular formula: C10H8N2O2S. Mole weight: 220.3. | |
MK-1775 Quick inquiry Where to buy Suppliers range | MK-1775, also known as AZD-1775, is a WEE1 inhibitor and a small-molecule inhibitor of the tyrosine kinase WEE1 with potential antineoplastic sensitizing activity. MK-1775 selectively targets and inhibits WEE1, a tyrosine kinase that phosphorylates cyclin-dependent kinase 1 (CDC2) to inactivate the CDC2/cyclin B complex. Inhibition of WEE1 activity prevents the phosphorylation of CDC2 and impairs the G2 DNA damage checkpoint. This may lead to apoptosis upon treatment with DNA damaging chemotherapeutic agents. Unlike normal cells, most p53-deficient or mutated human cancers lack the G1 checkpoint as p53 is the key regulator of the G1 checkpoint and these cells rely on the G2 checkpoint for DNA repair to damaged cells. Annulment of the G2 checkpoint may therefore make p53-deficient tumor cells more vulnerable to antineoplastic agents and enhance their cytotoxic effect. Synonyms: MK-1775; MK1775; MK 1775; AZD1775; AZD-1775; AZD 1775; adavosertib. 1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-[4-(4-methylpiperazin-1-yl)anilino]-2-prop-2-enylpyrazolo[3,4-d]pyrimidin-3-one. Grades: >98%. CAS No. 955365-80-7. Molecular formula: C27H32N8O2. Mole weight: 500.607. | |
Monalizumab Quick inquiry Where to buy Suppliers range | Monalizumab is a first-in-class immune checkpoint inhibitor that targets Natural Killer Group 2A (NKG2A). Monalizumab increased degranulation and IFN-γ production by NKG2A+ NK cell against HLA-E+ target cells, thereby promoting NK cell effector functions. Synonyms: IPH2201. CAS No. 1228763-95-8. | |
Monastrol Quick inquiry Where to buy Suppliers range | Monastrol is a kinesin Eg5 inhibitor. Induction of apoptosis by monastrol is independent of the spindle checkpoint. Monastrol binds to the KSP-ADP complex, forming a KSP-ADP-monastrol ternary complex, which cannot bind to microtubules productively and cannot undergo further ATP-driven conformational changes. Uses: Antimitotic agents. Synonyms: DL-Monastrol; (S)-Monastrol; (+/-)-Monastrol; 4-(3-Hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-4H-pyrimidin-5-carboxylic Acid Ethyl Ester. CAS No. 254753-54-3. Molecular formula: C14H16N2O3S. Mole weight: 292.36. | |
MPDL3280A Quick inquiry Where to buy Suppliers range | A human, Fc optimized, monoclonal antibody directed against the protein ligand PD-L1 (programmed cell death-1 ligand 1), with potential immune checkpoint inhibitory and antineoplastic activities. Atezolizumab binds to PD-L1, blocking its binding to and activation of its receptor programmed death 1 (PD-1) expressed on activated T-cells, which may enhance the T-cell-mediated immune response to neoplasms and reverse T-cell inactivation. In addition, by binding to PD-L1, atezolizumab also prevents binding of this ligand to B7.1 expressed on activated T cells, which further enhances the T-cell-mediated immune response. PD-L1 is overexpressed on many human cancer cell types and on various tumor-infiltrating immune cells. PD-L1 binding to PD-1 on T-cells suppresses the immune system and results in increased immune evasion. PD-1, a transmembrane protein, is a negative regulator of the immune system that limits the expansion and survival of CD8+ T cells. The Fc region of atezolizumab is modified in such a way that it does not induce either antibody-dependent cytotoxicity (ADCC) or complement-dependent cytotoxicity (CDC). Synonyms: Atezolizumab; RG 7446; RO 5541267; RG7446; RO5541267; RG-7446; RO-5541267; TECENTRIQ. CAS No. 1380723-44-3. Molecular formula: C37H62N4O2S. Mole weight: 627. | |
MPI-0479605 Quick inquiry Where to buy Suppliers range | MPI-0479605 is a potent and selective ATP competitive inhibitor of Mps1. Cells treated with MPI-0479605 undergo aberrant mitosis, resulting in aneuploidy and formation of micronuclei. In cells with wild-type p53, this promotes the induction of a postmitotic checkpoint characterized by the ATM- and RAD3-related-dependent activation of the p53-p21 pathway. In both wild-type and p53 mutant cells lines, there is a growth arrest and inhibition of DNA synthesis. Subsequently, cells undergo mitotic catastrophe and/or an apoptotic response. In xenograft models, MPI-0479605 inhibits tumor growth, suggesting that drugs targeting Mps1 may have utility as novel cancer therapeutics. Synonyms: MPI-0479605; MPI 0479605; MPI0479605. Grades: 0.98. CAS No. 1246529-32-7. Molecular formula: C22H29N7O. Mole weight: 407.522. | |
Mps1-IN-2 Quick inquiry Where to buy Suppliers range | Small-molecule inhibitor of Mps1 kinase (IC50 values 145 nM) with greater than 1000-fold selectivity relative to the 352-member kinase panel, with the major exceptions of Gak and Plk1 (Ambit essay Kd values 12 nM, 140 nM, and 61 nM for Mps1, Gak, and Plk1, respectively). Mps1-IN-2 induces bypass of a checkpoint-mediated mitotic arrest and provides a unique tool to investigate the combined inhibition of Plk1 and Mps1. Synonyms: Mps1-IN-2. Grades: >98%. CAS No. 1228817-38-6. Molecular formula: C26H36N6O3. Mole weight: 480.6. | |
MPS1 Inhibitor, NMS-P715 ( (N- (2, 6-diethylphenyl) -1-methyl-8- ({4-[ (1-methylpiperidin-4-yl) carbamoyl]-2- (trifluoromethoxy) phenyl}amino) -4, 5-dihydro-1H-pyrazolo[4, 3-h]quinazoline-3-carboxamide) ) Quick inquiry Where to buy Suppliers range | An orally bioavailable, ATP-competitive, pyrazolo-quinazoline, MPS1 inhibitor (IC50=182nM, Ki=0.99nM) that is shown to act in a reversible and time-dependent manner. It demonstrates selectivity for MPS1 against a panel of 60 kinases, displaying activity against only three kinases, CK2, MELK, and NEK6 (<10uM), but not against other mitotic kinases including PLK1, CDK1, Aurora A, Aurora B, or the SAC kinase BUB1, in an in vitro kinase assay. It promotes massive SAC (spindle assembly checkpoint) override (EC50=65nM) in nocodazole-arrested U20S cells and elicits a reduction in the G1 and G2/M phase of the cell cycle in A2780 ovarian cancer cells, similar to RNAi-mediated MPS1 silencing. In addition, it is shown to inactivate SAC, delocalize kinetochore components, and inhibit the proliferation of select cancer cell lines (IC50 ~1uM), without marked activity among a panel of 127 normal cell lines. Also, it inhibits A2780 tumor xenograft growth in mice (90mg/kg/day, o.s., in vivo) by 53% wit Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
MPS1/TTK Inhibitor Quick inquiry Where to buy Suppliers range | MPS1/TTK inhibitor is an inhibitor of monopolar spindle 1 (MPS1/TTK), a dual-specificity kinase playing an essential role in mitotic spindle checkpoint signaling that is overexpressed in certain cancerous tumors. Synonyms: N-(2,6-diethylphenyl)-4,5-dihydro-8-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-1-methyl-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide. Grades: ≥98%. CAS No. 1202055-39-7. Molecular formula: C33H40N8O2. Mole weight: 580.72. | |
N-Desmethyl Dovitinib Quick inquiry Where to buy Suppliers range | Dovitinib derivative; a benzimidazole quinolinone for inhibiting a checkpoint kinase 1 and its use in combination therapy for cancer. Group: Biochemicals. Alternative Names: 4-Amino-5-fluoro-3-[6-(1-piperazinyl)-1H-benzimidazol-2-yl]-. Grades: Highly Purified. CAS No. 668432-44-8. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
nivolumab Quick inquiry Where to buy Suppliers range | Nivolumab, marketed as Opdivo, is a humanized IgG4 anti-PD-1 monoclonal antibody used to treat cancer. Nivolumab works as a checkpoint inhibitor, blocking a signal that would have prevented activated T cells from attacking the cancer, thus allowing the immune system to clear the cancer. Synonyms: Opdivo; ONO-4538; BMS-936558; MDX1106; ONO4538; BMS936558; MDX 1106; ONO 4538; BMS 936558; MDX-1106. CAS No. 946414-94-4. | |
NSC 109555 dimesylate Quick inquiry Where to buy Suppliers range | NSC 109555 is a potent and selective inhibitor of checkpoint kinase 2 (Chk2), displaying no effect against other kinases. It inhibits H1 phosphorylation and attenuates mitochondrial ATP synthesis. NSC 109555 can be used in cancer therapy. Synonyms: DDUG; NCI C04808; Carbanilide, 4,4'-diacetyl-, 4,4'-bis(amidinohydrazone), dimethanesulfonate. CAS No. 15427-93-7. Molecular formula: C19H24N10O·2CH3SO3H. Mole weight: 600.7. | |
PD0166285 Quick inquiry Where to buy Suppliers range | PD0166285 is a potent Wee1 inhibitor and Chk1 inhibitor with activity at nanomolar concentrations. This G2 checkpoint abrogation by PD0166285 was demonstrated to kill cancer cells, there at a toxic highest dose of 0.5 muM in some cell lines for exposure periods of no longer than 6 hours. The deregulated cell cycle progression may have ultimately damaged the cancer cells. We herein report one of the mechanism by which PD0166285 leads to cell death in the B16 mouse melanoma cell line. Synonyms: PD166285; 6-(2,6-dichlorophenyl)-2-((4-(2-(diethylamino)ethoxy)phenyl)amino)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one; 6-(2,6-Dichlorophenyl)-2-[4-(2-diethylaminoethoxy)phenylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one; Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-(2,6-dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methyl-. Grades: ≥98%. CAS No. 185039-89-8. Molecular formula: C26H27Cl2N5O2. Mole weight: 512.44. | |
PD0407824 Quick inquiry Where to buy Suppliers range | PD0407824 is a potent and selective inhibitor of checkpoint kinase Chk1 and WEE1 with IC50s of 47 and 97 nM, respectively. It is a BMP chemical sensitizer that increases cell sensitivity to subthreshold amounts of BMP4. It has potential anticancer activity. Synonyms: PD 407824; 9-Hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione; Pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione, 9-hydroxy-4-phenyl-. Grades: ≥98%. CAS No. 622864-54-4. Molecular formula: C20H12N2O3. Mole weight: 328.32. | |
PD 166285 dihydrochloride Quick inquiry Where to buy Suppliers range | PD 166285, a novel protein tyrosine kinase inhibitor of a new structural class, is a potent inhibitor of the tyrosine kinases c-Src, Flg (fibroblast growth factor receptor 1, FGFR1), and PDGFRβ (platelet-derived growth factor receptor β) (IC50 values are 8.4, 39.3 and 98.3 nM respectively). PD 166285 also inhibits the checkpoint kinases Wee1 and MYT1 (Myt1), abolishes Cdc2 phosphorylation in numerous tumor cell lines, and abrogates the G2 checkpoint. Synonyms: PD 166285 dihydrochloride; PD166285 dihydrochloride; PD-166285 dihydrochloride6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one dihydrochloride. Grades: ≥99% by HPLC. CAS No. 212391-63-4. Molecular formula: C26H27Cl2N5O2.2HCl. Mole weight: 585.35. | |
PF-03814735 Quick inquiry Where to buy Suppliers range | PF-03814735 is an orally bioavailable, ATP-competitive, reversible small-molecule Aurora kinase inhibitor with potential antineoplastic activity. Aurora kinase inhibitor PF-03814735 binds to and inhibits Aurora kinases A and B, which may result in the inhibition of cellular division and proliferation in tumor cells that overexpress these kinases. Aurora kinases are serine-threonine kinases that play essential roles in mitotic checkpoint control during mitosis. Synonyms: PF03814735; PF-03814735; PF 03814735. Grades: >98%. CAS No. 942487-16-3. Molecular formula: C23H25F3N6O2. Mole weight: 474.48. | |
PF 477736 Quick inquiry Where to buy Suppliers range | Selective checkpoint kinase 1 (Chk1) inhibitor (Ki values are 0.49 and 47 nM for Chk1 and Chk2 respectively). Abrogates cell cycle arrest at S and G2-M checkpoints; sensitizes cells to DNA damage. Group: Biochemicals. Grades: Highly Purified. CAS No. 952021-60-2. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences. | Worldwide |
PF-477736 Quick inquiry Where to buy Suppliers range | PF-477736 is a proprietary compound targeting cell cycle checkpoint kinase 1 (chk1) with potential chemopotentiation activity. Chk1 inhibitor PF-477736 inhibits chk1, an ATP-dependent serine-threonine kinase that is a key component in the DNA replication-monitoring S/G2 checkpoint system. By overriding the last checkpoint defense against DNA damaging agent-induced lethal damage, chk1 inhibitor PF-477736 may potentiate the antitumor efficacy of various chemotherapeutic agents against tumor cells with intrinsic checkpoint defects. Synonyms: PF-477736; PF-477736; PF-477736; PF-00477736; PF00477736; PF 00477736. CAS No. 952021-60-2. Molecular formula: C22H25N7O2. Mole weight: 419.489. | |
Pidilizumab Quick inquiry Where to buy Suppliers range | A humanized, immunoglobulin (Ig) G1 monoclonal antibody directed against human inhibitory receptor programmed cell death 1 (PD-1; PDCD1), with potential immune checkpoint inhibitory and antineoplastic activities. Pidilizumab binds to PD-1 and blocks the interaction between PD-1 and its ligands, PD-1 ligand 1 (PD-L1) and PD-1 ligand 2 (PD-L2). This prevents the activation of PD-1 and its downstream signaling pathways. This may restore immune function through the activation of natural killer (NK) cells and cytotoxic T-lymphocytes (CTLs) against tumor cells. PD-1, an inhibitory receptor belonging to the B7-receptor family expressed on activated T-lymphocytes, B-cells and NK cells, negatively regulates T-cell activation and effector function when activated by its ligands; it plays an important role in tumor evasion from host immunity. Synonyms: CT-011; MDV 9300; CT 011; MDV9300; CT011; MDV-9300. CAS No. 1036730-42-3. | |
Poloxin Quick inquiry Where to buy Suppliers range | Poloxin is the first small-molecule inhibitor specifically targeting the function of the Plk1 PBD. Poloxin induces centrosome fragmentation and abnormal spindle and chromosome misalignment, which activate the spindle assembly checkpoint and prolong mitosis. Notably, centrosomal fragmentation induced by Poloxin is partially attributable to dysfunctional Kizuna, a key substrate of Plk1 at centrosomes. Moreover, Poloxin strongly inhibits proliferation of a panel of cancer cells by inducing mitotic arrest, followed by a surge of apoptosis. More important, we report, for the first time to our knowledge, that the PBD inhibitor, Poloxin, significantly suppresses tumor growth of cancer cell lines in xenograft mouse models by lowering the proliferation rate and triggering apoptosis in treated tumor tissues. Targeting the PBD by Poloxin is a powerful approach for selectively inhibiting Plk1 function in vitro and in vivo. Synonyms: Poloxin. Grades: 0.98. CAS No. 321688-88-4. Molecular formula: C18H19NO3. Mole weight: 297.354. | |
proTAME Quick inquiry Where to buy Suppliers range | proTAME is a cell-permeable prodrug of N-4-tosyl-L-arginine methyl ester (TAME), which is an inhibitor of the anaphase-promoting complex/cyclosome (APC/C) suppressing its activation by Cdc20 and Cdh1. It induces mitotic arrest by activating the spindle assembly checkpoint (SAC). Synonyms: Pro-N-4-tosyl-L-arginine methyl ester; Methyl (2S) -5- [bis [ (2-phenylacetyl) oxymethoxycarbonylamino] methylideneamino] -2- [ (4-methylphenyl) sulfonylamino] pentanoate. Grades: ≥90%. CAS No. 1362911-19-0. Molecular formula: C34H38N4O12S. Mole weight: 726.75. | |
(S)-2-Piperidineethanol Quick inquiry Where to buy Suppliers range | Useful in preparation of a novel class of pyrazolopyrimidines as inhibitors of protein and checkpoint kinases useful in treatment and prophylaxis of HCV infection and other diseases such as cancer. Group: Biochemicals. Grades: Highly Purified. CAS No. 103639-57-2. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
Sapacitabine Quick inquiry Where to buy Suppliers range | Sapacitabine is an orally bioavailable pyrimidine analogue prodrug with potential antineoplastic activity. Sapacitabine is hydrolyzed by amidases to the deoxycytosine analogue CNDAC (2'-Cyano-2'-deoxyarabinofuranosylcytosine), which is then phosphorylated into the active triphosphate form. As an analogue of deoxycytidine triphosphate, CNDAC triphosphate incorporates into DNA strands during replication, resulting in single-stranded DNA breaks during polymerization due to beta-elimination during the fidelity checkpoint process; cell cycle arrest in the G2 phase and apoptosis ensue. Synonyms: CS682; CYC682; CYC-682; Sapacitabine. CAS No. 151823-14-2. Molecular formula: C26H42N4O5. Mole weight: 490.645. | |
SCH900776 Quick inquiry Where to buy Suppliers range | SCH900776, also known as MK-8776. is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities. Chk1 inhibitor SCH 900776 specifically binds to and inhibits Chk1, which may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases to undergo DNA repair prior to entry into mitosis; tumor cells may thus be sensitized to the DNA-damaging effects of ionizing radiation and alkylating chemotherapeutic agents. Chk1 is an ATP-dependent serine-threonine kinase that in response to DNA damage phosphorylates cdc25 phosphatases, resulting in inhibitory tyrosine phosphorylation of CDK-cyclin complexes and cell cycle arrest. Synonyms: SCH-900776; SCH 900776, MK-8776; MK 8776; MK8776. Grades: >98%. CAS No. 891494-63-6. Molecular formula: C15H18BrN7. Mole weight: 376.262. | |
SCH900776 S-isomer Quick inquiry Where to buy Suppliers range | SCH900776 S-isomer is the S-isomer form of SCH900776, which is a potent, selective and orally bioavailable inhibitor of checkpoint kinase Chk1. It can be used as a protein kinase inhibitor useful in the treatment of protein kinase-mediated diseases. It enhances the γ-H2AX response of hydroxyurea, 5-fluoruracil, and cytarabine. It suppresses accumulation of the Chk1 pS296 autophosphorylation in a dose-dependent manner. Uses: Sch900776 s-isomer can be used as a protein kinase inhibitor useful in the treatment of protein kinase-mediated diseases. Synonyms: SCH900776 S-isomer; SCH 900776 S-isomer; SCH-900776 S-isomer; (S)-6-Bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(piperidin-3-yl)pyrazolo[1,5-A]pyrimidin-7-amine;6-Bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-((3S)-piperidin-3-yl)pyrazolo(1,5-a)pyrimidin-7-amine;SCH-900776 S-isomer. Grades: >98%. CAS No. 891494-64-7. Molecular formula: C15H18BrN7. Mole weight: 376.25. | |
(Ser(PO3H2)273)-Nek11 (268-283) Quick inquiry Where to buy Suppliers range | In undisturbed and DNA-damaged cells, depletion of NEK11 prevents proteasome-dependent CDC25A degradation. NEK11 directly phosphorylates CDC25A, and CHK1 (checkpoint kinase 1) is activated directly by phosphorylation of NEK11 at Ser273. NEK11 is an important component of the G2/M checkpoint pathway, and genetic mutations in NEK11 may contribute to cancer development. Synonyms: H-Leu-Asn-Lys-Asn-Pro-Ser(PO3H2)-Leu-Arg-Pro-Ser-Ala-Ile-Glu-Ile-Leu-Cys-OH; L-Cysteine, L-leucyl-L-asparaginyl-L-lysyl-L-asparaginyl-L-prolyl-O-phosphono-L-seryl-L-leucyl-L-arginyl-L-prolyl-L-seryl-L-alanyl-L-isoleucyl-L-α-glutamyl-L-isoleucyl-L-leucyl-. Grades: ≥95%. CAS No. 2243207-06-7. Molecular formula: C77H135N22O26PS. Mole weight: 1848.09. | |
(Ser(PO3H2)516)-Artemis (511-523) Quick inquiry Where to buy Suppliers range | Artemis, a phosphorylated protein, plays a role in V(D)J recombination, non-homologous end-joining of double-strand breaks, and regulation of G2/M cell cycle checkpoints induced by DNA damage. Synonyms: H-Thr-Val-Ala-Gly-Gly-Ser(PO3H2)-Gln-Ser-Pro-Lys-Leu-Phe-Ser-OH; L-Serine, L-threonyl-L-valyl-L-alanylglycylglycyl-O-phosphono-L-seryl-L-glutaminyl-L-seryl-L-prolyl-L-lysyl-L-leucyl-L-phenylalanyl-. Grades: ≥95%. CAS No. 2243207-01-2. Molecular formula: C56H92N15O22P. Mole weight: 1358.41. | |
SNS-314 Quick inquiry Where to buy Suppliers range | SNS-314 is a synthetic small molecule Aurora kinase (AK) inhibitor with potential antineoplastic activity. Aurora kinase inhibitor SNS-314 selectively binds to and inhibits AKs A and B, which may result in the inhibition of cellular division and proliferation in tumor cells that overexpress AKs. AKs are serine-threonine kinases that play essential roles in mitotic checkpoint control during mitosis. Synonyms: SNS314; SNS 314; N-(3-chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]Urea. Grades: >98%. CAS No. 1057249-41-8. Molecular formula: C18H15ClN6OS2. Mole weight: 430.93. | |
SU5607 (IC261) Quick inquiry Where to buy Suppliers range | SU5607 is a potent and selective CK1 inhibitor. It triggers the mitotic checkpoint and induces p53-dependent postmitotic effects. Synonyms: IC 261; SU-5607; 3-[(2,4,6-Trimethoxyphenyl)methylidenyl]-indolin-2-one; (3E)-3-[(2,4,6-trimethoxyphenyl)methylidene]-1H-indol-2-one. Grades: >98%. CAS No. 186611-52-9. Molecular formula: C18H17NO4. Mole weight: 311.34. | |
TCS 2312 Quick inquiry Where to buy Suppliers range | TCS 2312 is a potent checkpoint kinase 1 (chk1) inhibitor (Ki = 0.38 nM, EC50 = 60 nM). TCS 2312 potentiates the cell killing activity of Gemcitabine in breast and prostate cancer cell lines, and exhibits antiproliferative effects in vitro. Synonyms: TCS 2312; TCS2312; TCS-2312; 4'-[5-[[3-[ (Cyclopropylamino) methyl]phenyl]amino]-1H-pyrazol-3-yl]-[1, 1'-biphenyl]-2, 4-diol. Grades: ≥97% by HPLC. CAS No. 838823-31-7. Molecular formula: C25H24N4O2. Mole weight: 412.48. | |
Tiragolumab Quick inquiry Where to buy Suppliers range | Tiragolumab is a humanized monoclonal antibody and immune checkpoint inhibitor that selectively binds to TIGIT, which suppresses the immune response to cancer. Synonyms: anti-TIGIT; RG6058; MTIG7192A. CAS No. 1918185-84-8. | |
Tremelimumab Quick inquiry Where to buy Suppliers range | A human immunoglobulin (Ig) G2 monoclonal antibody directed against the human T-cell receptor protein cytotoxic T-lymphocyte-associated protein 4 (CTLA4), with potential immune checkpoint inhibitory and antineoplastic activities. Tremelimumab binds to CTLA4 on activated T-lymphocytes and blocks the binding of the antigen-presenting cell ligands B7-1 (CD80) and B7-2 (CD86) to CTLA4, resulting in inhibition of CTLA4-mediated downregulation of T-cell activation. This promotes the interaction of B7-1 and B7-2 with another T-cell surface receptor protein CD28, and results in a B7-CD28-mediated T-cell activation that is unopposed by CTLA4-mediated inhibition. This leads to a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells. CTLA4, an inhibitory receptor and member of the immunoglobulin superfamily, plays a key role in the downregulation of the immune system. Synonyms: CP-675; CP 675; CP675; CP-675,206. CAS No. 745013-59-6. | |
Trichostatin A (TSA, A300, R-(E,E)-7-(4-(dimethylamino)phenyl)-N-hydroxy- 4,6-dimethyl-7-oxo-2,4-heptadienamide) Quick inquiry Where to buy Suppliers range | Antibiotic. Antifungal. Antiprotozoal. Potent and reversible, cell permeable inhibitor of histone deacetylase (HDAC). Immunosuppressive. Anticancer compound. Antifibrogenic. Apoptosis inducer. Induces cell growth arrest at both G1 and G2/M phases. Enhances the efficacy of anticancer agents that target DNA. Inactivates mitotic spindle checkpoint. Smooth muscle cell proliferation inhibitor. Telomerase inhibitor. Downregulates DNA methyltransferase DNMT1 and affects DNA methylation. Anti-inflammatory. Inhibits osteoclastogenesis and bone resorption. Group: Biochemicals. Alternative Names: TSA, A300, R-(E,E)-7-(4-(dimethylamino)phenyl)-N-hydroxy- 4,6-dimethyl-7-oxo-2,4-heptadienamide. Grades: Highly Purified. CAS No. 58880-19-6. Pack Sizes: 1mg, 5mg. Molecular Formula: C17H22N2O3, Molecular Weight: 302.4. US Biological Life Sciences. | Worldwide |