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| Product | Description | |
|---|---|---|
| 2-Amino-4-chloro-6-methoxy-pyrimidine | 2-Amino-4-chloro-6-methoxy-pyrimidine is one of the two major metabolites formed in the degradation of chlorimuron-ethyl; a pre- and post-emergence herbicide for the control of important broad-leaved weeds in soybean and maize. Group: Biochemicals. Grades: Highly Purified. CAS No. 5734-64-5. Pack Sizes: 10g, 25g. Molecular Formula: C5H6ClN3O, Molecular Weight: 159.57. US Biological Life Sciences. |  Worldwide |
| 4-Chloro-5-methoxy-2-(methylthio)pyrimidine | 4-Chloro-5-methoxy-2- (methylthio) pyrimidine. Group: Biochemicals. Grades: Highly Purified. CAS No. 87026-45-7. Pack Sizes: 250mg, 500mg, 1g, 2g, 5g. US Biological Life Sciences. | Worldwide |
| 5-Chloro-2-methoxy-pyrimidine | 5-Chloro-2-methoxy-pyrimidine. Group: Biochemicals. Grades: Highly Purified. CAS No. 38373-44-3. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. US Biological Life Sciences. | Worldwide |
| Mirk/Dyrk1B Inhibitor, Compound A (N- (2-Chloro-5- (3-chlorobenzylcarbamoyl) phenyl) -2-methoxy-7-oxo-7, 8-dihydropyrido[2, 3-d]pyrimidine-6-carboxamide, N- (2-Chloro-5- ( (3-chlorobenzyl) carbamoyl) phenyl) -7-hydroxy-2-methoxypyrido[2, 3-d]pyrimidine-6-carboxamide) | A cell-permeable di hydropyridopyrimidine-carboxamide compound that acts as a potent and reversible inhibitor of Mirk/Dyrk1B and Dyrk1A kinases (IC50 = 68 and 22nM). Exhibits very high selectivity for Mirk/Dyrk1B compared to Abl, Flt3, and MARK1 (64, 56 and 73% inhibition at 10uM, respectively) and a panel of 46 other kinases. Shown to induce activation of caspase-3 and sensitize tumor cells to the action of gemcitabine and cisplatin, possibly by de-stabilizing p27. Preferentially increases cycling in Mirk-elevated quiescent pancreatic cancer cells (SU86.86, Panc1, AsPc1, and SW620 at ~1uM). Also, shown to increase level of superoxides in quiescent pancreatic tumor cells (Panc1, SU86.86, and AsPc1) by blocking SOD2 and SOD3 activities. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 2-Chloro-6-methoxy-pyridine | 2-Chloro-6-methoxy-pyridine is a reagent used to synthesize imidazo[1,2-a]pyrimidines as functionally selective GABAA ligands. It can also be used to synthesize oxazolidinedione-arylpyridinones as EP3 receptor antagonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 17228-64-7. Pack Sizes: 5g, 25 g. Molecular Formula: C6H6ClNO, Molecular Weight: 143.57. US Biological Life Sciences. | Worldwide |
| 6-Chloro-2-phenyl-4-pyrimidinyl4-methoxybenzylether | Heterocyclic Organic Compound. Alternative Names: 6-chloro-2-phenyl-4-pyrimidinyl 4-methoxybenzyl ether, 1044559-74-1, CTK7A4093, MolPort-009-195-964, ZINC40566607, AKOS005072518, AG-C-08255, chlorophenyl pyrimidinyl methoxybenzyl ether, FD-0705, RP16593, AK-70436, KB-248314, 4-Chloro-6-((4-methoxybenzyl)oxy)-2-phenylpyrimidine, 4-chloro-6-[(4-methoxyphenyl)methoxy]-2-phenylpyrimidine. CAS No. 1044559-74-1. Molecular formula: C18H15ClN2O2. Mole weight: 326.79. Purity: 0.96. IUPACName: 4-chloro-6-[(4-methoxyphenyl)methoxy]-2-phenylpyrimidine. Canonical SMILES: COC1=CC=C (C=C1)COC2=CC (=NC (=N2)C3=CC=CC=C3)Cl. Catalog: ACM1044559741. |  |
| 7-[3,5-Bis-O-[(2,4-dichlorophenyl)methyl]-2-C-methyl-beta-D-ribofuranosyl]-4-chloro-5-methyl-7H-pyrrolo[2,3-d]pyrimidine | 7-[3,5-Bis-O-[(2,4-dichlorophenyl)methyl]-2-C-methyl-beta-D-ribofuranosyl]-4-chloro-5-methyl-7H-pyrrolo[2,3-d]pyrimidine, a highly intricate and dynamic compound, exhibits remarkable antiviral properties. This remarkable pharmaceutical marvel has been harnessed specifically for combating viral infections, offering a powerful mechanism of action that disrupts viral replication by precisely targeting crucial enzymes involved in viral DNA synthesis. Synonyms: (3R,4R,5R)-2-(4-chloro-5-methylpyrrolo[2,3-d]pyrimidin-7-yl)-4-[(2,4-dichlorophenyl)methoxy]-5-[(2,4-dichlorophenyl)methoxymethyl]-3-methyloxolan-3-ol;NU008035;443642-54-4. Grades: 95%. CAS No. 443642-54-4. Molecular formula: C27H24Cl5N3O4. Mole weight: 631.76. |  |
| Mirk-IN-1 | Mirk-IN-1, a pyrido[2,3-d]pyrimidine derivative, has been found to be a DYRK1A/B inhibitor and probably have antitumor activity through influencing the accumulation and induce the DNA damage and apoptosis of Panc1 in tumor cells. IC50: 68±48/22±8 nM (Dyrk. Uses: Mirk-in-1 has been found to be a dyrk1a/b inhibitor and probably have antitumor activity through influencing the accumulation and induce the dna damage and apoptosis of panc1 in tumor cells. Synonyms: Dyrk1B/1A-IN-9; Dyrk1B inhibitor; 1A-IN-9; Dyrk-1B/1A-IN-9; Dyrk 1B/1A IN 9; Dyrk1B/1A-inhibitor-9; Mirk-IN-1; CHEMBL3094448; SCHEMBL10446906; CQKBSRPVZZLCJE-UHFFFAOYSA-N; BDBM50444379; AKOS025147328; N-[2-chloro-5-[(3-chlorophenyl)methylcarbamoyl]phenyl]-2-methoxy-7-oxo-8H-pyrido[2,3-d]pyrimidine-6-carboxamide. Grades: 98%. CAS No. 1386979-55-0. Molecular formula: C23H17Cl2N5O4. Mole weight: 498.32. | |
| Pyrimidine,4-bromo-6-chloro- | Heterocyclic Organic Compound. Alternative Names: 4-BROMO-6-CHLOROPYRIMIDINE;Pyrimidine, 4-bromo-6-chloro- (9CI);5-methoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine. CAS No. 126401-90-9. Molecular formula: C4H2BrClN2. Mole weight: 193.42908. Purity: 0.96. IUPACName: 5-methoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine. Canonical SMILES: C1=C(N=CN=C1Br)Cl. Density: 1.06g/cm³. Catalog: ACM126401909. | |
| TAE 684 | TAE 684. Group: Biochemicals. Alternative Names: NVP-TAE 684; NVT TAE-684; 5-Chloro-N2-[2-methoxy-4-[4- (4-methyl-1-piperazinyl) -1-piperidinyl]phenyl]-N4-[2-[ (1-methylethyl) sulfonyl]phenyl]-2, 4-pyrimidinediamine. Grades: Highly Purified. CAS No. 761439-42-3. Pack Sizes: 10mg. Molecular Formula: C30H40ClN7O3S, Molecular Weight: 614.2. US Biological Life Sciences. | Worldwide |
| WZ-4002 | WZ-4002 is an EGFR phosphorylation inhibitor with selectivity for EGFR T790M. It has a framework of pyrimidine compound which is different from other EGFR inhibitors. WZ-4002 exhibits anti-tumor activity. Uses: Protein kinase inhibitors. Synonyms: WZ4002; N-(3-(5-chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide; WZ 4002. CAS No. 1213269-23-8. Molecular formula: C25H27ClN6O3. Mole weight: 494.98. | |
| (1S,2S,3S,5R)-3-(2-Hydroxyethoxy)-5-[7-methoxy-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-1,2-cyclopentanediol | (1S,2S,3S,5R)-3-(2-Hydroxyethoxy)-5-[7-methoxy-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-1,2-cyclopentanediol is an intermediate in the synthesis of (1S,2S,3R,5S)-3-[7-Chloro-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)-1,2-cyclopentanediol which is used in preparation of metaboltes of Ticagrelor (T437700) which is the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Group: Biochemicals. Grades: Highly Purified. CAS No. 2024557-22-8. Pack Sizes: 250mg, 500mg. Molecular Formula: C15H23N5O5S. US Biological Life Sciences. | Worldwide |
| 2-[3-(2-Chlorophenyl)propyl]-6-methoxy-N-methylbenzamide | Heterocyclic Organic Compound. CAS No. 1171923-12-8. Molecular formula: C18H20ClNO2. Mole weight: 317.81. Purity: 0.96. IUPACName: 5-ethylsulfonyl-2-(imidazo[1,2-a]pyrimidin-2-ylmethylsulfanyl)-1,3-benzoxazole. Canonical SMILES: CCS (=O) (=O)C1=CC2=C (C=C1)OC (=N2)SCC3=CN4C=CC=NC4=N3. Catalog: ACM1171923128. | |
| 2-Chloro-5-methoxy-4-pyrimidinamine | The preparation and synthesis of 2-Chloro-5-methoxy-4-pyrimidinamine. Group: Biochemicals. Grades: Highly Purified. CAS No. 99979-77-8. Pack Sizes: 100mg, 250mg. Molecular Formula: C5H6ClN3O, Molecular Weight: 159.57. US Biological Life Sciences. | Worldwide |
| 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-7-methoxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one | 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-7-methoxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-7-methoxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one | Heterocyclic Organic Compound. Alternative Names: 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-7-methoxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one. CAS No. 130049-80-8. Molecular formula: C12H17ClN2O2. Mole weight: 256.72858. Appearance: Brown Oil. Purity: 0.96. IUPACName: 3-(2-chloroethyl)-7-methoxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one. Canonical SMILES: CC1=C(C(=O)N2CC(CCC2=N1)OC)CCCl. Density: 1.31g/cm³. Catalog: ACM130049808. | |
| 3-(2-Chloroethyl)-7-methoxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one | The compound has long-acting antipsychotic properties useful in the treatment of warm-blooded animals. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 5-[2-Amino-4-chloro-7-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-2-methyl-4-pentyn-2-ol | 5-[2-Amino-4-chloro-7-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-2-methyl-4-pentyn-2-ol. Group: Biochemicals. Alternative Names: EC144. Grades: Highly Purified. CAS No. 911397-80-3. Pack Sizes: 2.5mg. Molecular Formula: C21H24ClN5O2, Molecular Weight: 413.9. US Biological Life Sciences. | Worldwide |
| 5-[[2-Amino-5-[2-(4-chlorophenyl)diazenyl]-6-methoxy-4-pyrimidinyl]amino-13C2, 15N]-3- (phenylmethoxy)-2-[ (phenylmethoxy)methyl]-cyclopentanol | Intermediate in the synthesis of Entecavir. Group: Biochemicals. Alternative Names: (1S, 2S, 3S, 5S)-5-[[2-Amino-5-[2- (4-chlorophenyl)diazenyl]-6-methoxy-4-pyrimidinyl]amino-13C2, 15N]-3- (phenylmethoxy)-2-[ (phenylmethoxy)methyl]-cyclopentanol. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 5-[[2-Amino-5-[2- (4-chlorophenyl)diazenyl]-6-methoxy-4-pyrimidinyl]amino]-3- (phenylmethoxy)-2-[ (phenylmethoxy)methyl]-cyclopentanol | 5-[[2-Amino-5-[2- (4-chlorophenyl)diazenyl]-6-methoxy-4-pyrimidinyl]amino]-3- (phenylmethoxy)-2-[ (phenylmethoxy)methyl]-cyclopentanol is an intermediate in the synthesis of Entecavir (E558900). Group: Biochemicals. Alternative Names: (1S, 2S, 3S, 5S)-5-[[2-Amino-5-[2- (4-chlorophenyl)diazenyl]-6-methoxy-4-pyrimidinyl]amino]-3- (phenylmethoxy)-2-[ (phenylmethoxy)methyl]-cyclopentanol. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 5-[[2-Amino-5-[2-(4-chlorophenyl)diazenyl]-6-methoxy-4-pyrimidinyl]amino]-3-(phenylmethoxy)-2-[(phenylmethoxy)methyl]-cyclopentanol | 5-[[2-Amino-5-[2-(4-chlorophenyl)diazenyl]-6-methoxy-4-pyrimidinyl]amino]-3-(phenylmethoxy)-2-[(phenylmethoxy)methyl]-cyclopentanol is an intermediate in the synthesis of Entecavir. Synonyms: (1S,2S,3S,5S)-5-[[2-Amino-5-[2-(4-chlorophenyl)diazenyl]-6-methoxy-4-pyrimidinyl]amino]-3-(phenylmethoxy)-2-[(phenylmethoxy)methyl]-cyclopentanol. Molecular formula: C31H33ClN6O4. Mole weight: 589.08. | |
| ALK inhibitor 2 | ALK inhibitor 2 is a novel and selective inhibitor for the ALK kinase. Synonyms: Benzenesulfonamide, 2-[[5-chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methyl-. Grades: >98%. CAS No. 761438-38-4. Molecular formula: C23H28ClN7O3S. Mole weight: 518.03. | |
| BI-3812 | BI-3812 is potent and efficacious BCL6 inhibitor. It inhibits the BTB domain of BCL6 with an IC50 of ≤3 nM. The high potency and good permeability properties of BI-3812 make this molecule a very good cellular probe compound for testing hypotheses around BCL6 biology. The transcription factor BCL6 is a known driver of oncogenesis in lymphoid malignancies, including diffuse large B cell lymphoma (DLBCL). Synonyms: BI-3812; 2166387-64-8; CHEMBL4755229; 1-(5-chloro-4-((8-methoxy-1-methyl-3-(2-(methylamino)-2-oxoethoxy)-2-oxo-1,2-dihydroquinolin-6-yl)amino)pyrimidin-2-yl)-N,N-dimethylpiperidine-4-carboxamide; SCHEMBL20284237; AMY16876; BCP31903; EX-A2841; BDBM50546197; s8735; AKOS040741329; SB40386; BI 3812; BI3812; AC-31571; MS-30157; HY-111381; CS-0040299; A935150; EN300-22885148; Z3417458909; 1-[5-chloro-4-({8-methoxy-1-methyl-3-[(methylcarbamoyl)methoxy]-2-oxo-1,2-dihydroquinolin-6-yl}amino)pyrimidin-2-yl]-N,N-dimethylpiperidine-4-carboxamide; 1-[5-Chloro-4-({8-methoxy-1-methyl-3-[2-(methylamino)-2-oxoethoxy]-2-oxo-1,2-dihydro-6-quinolinyl}amino)-2-pyrimidinyl]-N,N-dimethyl-4-piperidinecarboxamide; 1-[5-chloro-4-[[8-methoxy-1-methyl-3-[2-(methylamino)-2-oxoethoxy]-2-oxoquinolin-6-yl]amino]pyrimidin-2-yl]-N,N-dimethylpiperidine-4-carboxamide. Grades: ≥98%. CAS No. 2166387-64-8. Molecular formula: C26H32ClN7O5. Mole weight: 558.03. | |
| CEP-28122 | CEP-28122 is a highly potent and selective oral anaplastic lymphoma kinase inhibitor with antitumor activity in experimental human cancer models. Synonyms: CEP 28122; CEP28122; Bicyclo[2.2.1]hept-5-ene-2-carboxamide, 3-[[5-chloro-2-[[(7S)-6,7,8,9-tetrahydro-1-methoxy-7-(4-morpholinyl)-5H-benzocyclohepten-2-yl]amino]-4-pyrimidinyl]amino]-, (1S,2S,3R,4R)-; (1S,2S,3R,4R)-3-[[5-Chloro-2-[[(7S)-6,7,8,9-tetrahydro-1-methoxy-7-(4-morpholinyl)-5H-benzocyclohepten-2-yl]amino]-4-pyrimidinyl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxamide. Grades: ≥95%. CAS No. 1022958-60-6. Molecular formula: C28H35ClN6O3. Mole weight: 539.07. | |
| CZC-54252 HCl | CZC-54252 is a potent inhibitor of leucine-rich repeat kinase 2 (LRRK2) with IC50 values 1.28 nM and 1.85 nM for wild-type and G2019S mutant forms of LRRK2 respectively. CZC-54252 attenuates neuronal injury induced by LRRK2-G2019S mutant activity in primary human neurons (EC50 = 1 nM). Activating mutations in leucine-rich repeat kinase 2 (LRRK2) are present in a subset of Parkinson's disease (PD) patients and may represent an attractive therapeutic target. Group: Inhibitors. Alternative Names: CZC-54252 HCl; CZC-54252 hydrochloride; CZC-54252; CZC 54252; CZC54252. CAS No. 1784253-05-9. Molecular formula: C22H26Cl2N6O4S. Mole weight: 541.45. Appearance: Solid powder. Purity: >98%. IUPACName: N-(2-((5-chloro-2-((2-methoxy-4-morpholinophenyl)amino)pyrimidin-4-yl)amino)phenyl)methanesulfonamide hydrochloride. Canonical SMILES: CS (=O) (NC1=CC=CC=C1NC2=NC (NC3=CC=C (N4CCOCC4)C=C3OC)=NC=C2Cl)=O. [H]Cl. Catalog: ACM1784253059. | |
| GW 803430 | GW 803430 is a potent and selective melanin-concentrating hormone receptor 1 (MCH1) antagonist (IC50 = 9.3 nM). GW 803430 exhibits antiobesity and antidepressant-like effects in rats and mice. Synonyms: GW-803430; GW 803430; GW803430. 6-(4-Chlorophenyl)-3-[3-methoxy-4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-thieno[3,2-d]pyrimidin-4(3H)-one. Grades: ≥99% by HPLC. CAS No. 515141-51-2. Molecular formula: C25H24ClN3O3S. Mole weight: 481.99. | |
| Methyl 2-(N-(4-chloro-6-methoxypyrimidin-2-ylcarbamoyl)sulfamoyl)benzoate | Heterocyclic Organic Compound. Alternative Names: CID182917, Methyl 2-[(4-chloro-6-methoxy-pyrimidin-2-yl)carbamoylsulfamoyl]benzoate, 128569-20-0. CAS No. 128569-20-0. Molecular formula: C14H13ClN4O6S. Mole weight: 400.794220 [g/mol]. Purity: 0.96. IUPACName: methyl 2-[(4-chloro-6-methoxypyrimidin-2-yl)carbamoylsulfamoyl]benzoate. Canonical SMILES: COC1=CC (=NC (=N1)NC (=O)NS (=O) (=O)C2=CC=CC=C2C (=O)OC)Cl. Density: 1.533g/cm³. Catalog: ACM128569200. | |
| MIK665 | MIK665 is an inhibitor of induced myeloid leukemia cell differentiation protein Mcl-1 with potential pro-apoptotic and antineoplastic activities. Synonyms: MIK-665; MIK 665; S64315; 2-[5-[3-chloro-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl]oxy-3-[2-[[2-(2-methoxyphenyl)pyrimidin-4-yl]methoxy]phenyl]propanoic acid. CAS No. 1799631-75-6. Molecular formula: C47H44ClFN6O6S. Mole weight: 875.41. | |
| Moxonidine | Moxonidine is an antihypertensive agent. Group: Biochemicals. Alternative Names: 4-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methyl-5-pyrimidinamine; 2-(6-Chloro-4-methoxy-2-methylpyrimidin-5-ylamino)-2-imidazoline; Lomox; Moxon; Norcynt; Normoxocin; Nucynt; Physiotens. Grades: Highly Purified. CAS No. 75438-57-2. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Moxonidine | Moxonidine is a selective agonist at the imidazoline receptor subtype (I1). It binds with much greater affinity to the imidazoline I1-receptor than to the α2-receptor while clonidine binds to both receptors with equal affinity. Uses: Antihypertensive agents. Synonyms: 4-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methyl-5-pyrimidinamine; 2-(6-Chloro-4-methoxy-2-methylpyrimidin-5-ylamino)-2-imidazoline; Lomox; Moxon; Norcynt; Normoxocin; Nucynt; Physiotens. Grades: >98%. CAS No. 75438-57-2. Molecular formula: C9H12ClN5O. Mole weight: 241.68. | |
| MRTX849 | MRTX849 is a potent and mutation-selective covalent inhibitor of KRAS G12C. It maximizes inhibition by irreversibly locking the KRAS molecule in its inactive state, thereby preventing tumor cell growth which results in tumor cell death. Uses: Antineoplastic agents. Synonyms: MRTX-849; MRTX 849; Adagrasib; 2-((S)-4-(7-(8-Chloronaphthalen-1-yl)-2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-1-(2-fluoroacryloyl)piperazin-2-yl)acetonitrile. CAS No. 2326521-71-3. Molecular formula: C32H35ClFN7O2. Mole weight: 604.12. | |
| N-(4-Chloro-6-methoxy-2-pyrimidinyl)-N,N-dimethylamine | Heterocyclic Organic Compound. CAS No. 13012-26-5. Molecular formula: C7H10ClN3O. Mole weight: 187.63. Catalog: ACM13012265. | |
| S-63845 | S-63845 is a selective inhibitor of MCL1 (Ki (MCL1, FP) < 1.2 nM; Kd (MCL1, SPR) = 0.19 nM; Ki (BCL2, FP)> 10.000 1.2 nM; Ki (BCL-XL, FP) > 10.000 1.2 nM). It has high affinity for the BH3-binding groove of MCL1. Study in vitro showed that S63845 could kill MCL1-dependent cancer cells; Study in vivo indicated that its potent antineoplastic activity and with an acceptable safety margin in different cancers. S63845 is promisingly to be an antineoplastic drug of various cancers. Uses: Antineoplastic drug. Synonyms: S63845; S-63845; S 63845. (R)-2-((5-(3-chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(5-fluorofuran-2-yl)thieno[2,3-d]pyrimidin-4-yl)oxy)-3-(2-((1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)methoxy)phenyl)propanoic acid. CAS No. 1799633-27-4. Molecular formula: C39H37ClF4N6O6S. Mole weight: 829.2646. | |
| YKL-05-099 | YKL-05-099 is a selective inhibitor of Salt-Inducible Kinase (SIK). Group: Inhibitors. Alternative Names: YKL-05-099; YKL 05 099; YKL05099. CAS No. 1936529-65-5. Molecular formula: C32H34ClN7O3. Mole weight: 600.12. Appearance: Solid powder. Purity: >98%. IUPACName: 3-(2-Chloro-6-methylphenyl)-7-((2-methoxy-4-(1-methylpiperidin-4-yl)phenyl)amino)-1-(5-methoxypyridin-2-yl)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one. Canonical SMILES: O=C1N (C2=NC=C (OC)C=C2)C3=NC (NC4=CC=C (C5CCN (C)CC5)C=C4OC)=NC=C3CN1C6=C (C)C=CC=C6Cl. Catalog: ACM1936529655. | |
| Zunsemetinib | Zunsemetinib is a tyrosine kinase inhibitor. Synonyms: [1(2H),4'-Bipyridin]-2-one, 3-chloro-4-[(3,5-difluoro-2-pyridinyl)methoxy]-2'-[2-(1-hydroxy-1-methylethyl)-4-pyrimidinyl]-5',6-dimethyl-, (-)-. Grades: >98%. CAS No. 1640282-42-3. Molecular formula: C25H22ClF2N5O3. Mole weight: 513.92. | |
| ZX-29 | ZX-29 is a potent and selective ALK inhibitor for ALK, ALK L1196M and ALK G1202R mutations, respectively. ZX-29 is inactive against EGFR. ZX-29 induces apoptosis by inducing endoplasmic reticulum (ER) stress and overcomes cell resistance caused by an ALK mutation. ZX-29 also induces protective autophagy and has antitumor effect. Group: Inhibitors. Alternative Names: ZX-29; ZX29; ZX 29. CAS No. 2254805-62-2. Molecular formula: C23H28ClN7O3S. Mole weight: 518.03. Appearance: Solid powder. Purity: >98%. IUPACName: N-(2-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)methanesulfonamide. Canonical SMILES: CS (=O) (NC1=CC=CC=C1NC2=NC (NC3=CC=C (N4CCN (C)CC4)C=C3OC)=NC=C2Cl)=O. Catalog: ACM2254805622. | |
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