Chloro Methoxy Pyrimidine Suppliers USA
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Product | Description | |
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2-Amino-4-chloro-6-methoxy-pyrimidine Quick inquiry Where to buy Suppliers range | 2-Amino-4-chloro-6-methoxy-pyrimidine is one of the two major metabolites formed in the degradation of chlorimuron-ethyl; a pre- and post-emergence herbicide for the control of important broad-leaved weeds in soybean and maize. Group: Biochemicals. Grades: Highly Purified. CAS No. 5734-64-5. Pack Sizes: 10g, 25g. Molecular Formula: C5H6ClN3O, Molecular Weight: 159.57. US Biological Life Sciences. | Worldwide |
5-Chloro-2-methoxy-pyrimidine Quick inquiry Where to buy Suppliers range | 5-Chloro-2-methoxy-pyrimidine. Group: Biochemicals. Grades: Highly Purified. CAS No. 38373-44-3. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. US Biological Life Sciences. | Worldwide |
5-Chloro-2-methoxy-pyrimidine-4-carboxylic acid Quick inquiry Where to buy Suppliers range | 5-chloro-2-methoxypyrimidine-4-carboxylic acid, 38275-36-4, 5-chloro-2-methoxy-pyrimidine-4-carboxylic Acid, F2124-0046, SCHEMBL9194921, DTXSID10406771, STL227766, AKOS000268604, CS-0303323, F78174, Z1198170113. | |
4-Chloro-5-methoxy-2-(methylthio)pyrimidine Quick inquiry Where to buy Suppliers range | 4-Chloro-5-methoxy-2- (methylthio) pyrimidine. Group: Biochemicals. Grades: Highly Purified. CAS No. 87026-45-7. Pack Sizes: 250mg, 500mg, 1g, 2g, 5g. US Biological Life Sciences. | Worldwide |
4-Chloro-5-fluoro-6-methoxy-2-(methylsulfonyl)pyrimidine Quick inquiry Where to buy Suppliers range | 4-Chloro-5-fluoro-6-methoxy-2-(methylsulfonyl)pyrimidine. Group: Pyridines. Grades: 97%. CAS No. 1824455-94-8. Product ID: ACM1824455948. Molecular formula: C6H6ClFN2O3S. Mole weight: 240.64. | |
Mirk/Dyrk1B Inhibitor, Compound A (N- (2-Chloro-5- (3-chlorobenzylcarbamoyl) phenyl) -2-methoxy-7-oxo-7, 8-dihydropyrido[2, 3-d]pyrimidine-6-carboxamide, N- (2-Chloro-5- ( (3-chlorobenzyl) carbamoyl) phenyl) -7-hydroxy-2-methoxypyrido[2, 3-d]pyrimidine-6-carboxamide) Quick inquiry Where to buy Suppliers range | A cell-permeable di hydropyridopyrimidine-carboxamide compound that acts as a potent and reversible inhibitor of Mirk/Dyrk1B and Dyrk1A kinases (IC50 = 68 and 22nM). Exhibits very high selectivity for Mirk/Dyrk1B compared to Abl, Flt3, and MARK1 (64, 56 and 73% inhibition at 10uM, respectively) and a panel of 46 other kinases. Shown to induce activation of caspase-3 and sensitize tumor cells to the action of gemcitabine and cisplatin, possibly by de-stabilizing p27. Preferentially increases cycling in Mirk-elevated quiescent pancreatic cancer cells (SU86.86, Panc1, AsPc1, and SW620 at ~1uM). Also, shown to increase level of superoxides in quiescent pancreatic tumor cells (Panc1, SU86.86, and AsPc1) by blocking SOD2 and SOD3 activities. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
5-[2-Amino-4-chloro-7-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-2-methyl-4-pentyn-2-ol Quick inquiry Where to buy Suppliers range | 5-[2-Amino-4-chloro-7-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-2-methyl-4-pentyn-2-ol. Group: Biochemicals. Alternative Names: EC144. Grades: Highly Purified. CAS No. 911397-80-3. Pack Sizes: 2.5mg. Molecular Formula: C21H24ClN5O2, Molecular Weight: 413.9. US Biological Life Sciences. | Worldwide |
(1S,2S,3S,5R)-3-(2-Hydroxyethoxy)-5-[7-methoxy-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-1,2-cyclopentanediol Quick inquiry Where to buy Suppliers range | (1S,2S,3S,5R)-3-(2-Hydroxyethoxy)-5-[7-methoxy-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-1,2-cyclopentanediol is an intermediate in the synthesis of (1S,2S,3R,5S)-3-[7-Chloro-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)-1,2-cyclopentanediol which is used in preparation of metaboltes of Ticagrelor (T437700) which is the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Group: Biochemicals. Grades: Highly Purified. CAS No. 2024557-22-8. Pack Sizes: 250mg, 500mg. Molecular Formula: C15H23N5O5S. US Biological Life Sciences. | Worldwide |
2-Chloro-5-methoxy-4-pyrimidinamine Quick inquiry Where to buy Suppliers range | The preparation and synthesis of 2-Chloro-5-methoxy-4-pyrimidinamine. Group: Biochemicals. Grades: Highly Purified. CAS No. 99979-77-8. Pack Sizes: 100mg, 250mg. Molecular Formula: C5H6ClN3O, Molecular Weight: 159.57. US Biological Life Sciences. | Worldwide |
2-Chloro-6-methoxy-pyridine Quick inquiry Where to buy Suppliers range | 2-Chloro-6-methoxy-pyridine is a reagent used to synthesize imidazo[1,2-a]pyrimidines as functionally selective GABAA ligands. It can also be used to synthesize oxazolidinedione-arylpyridinones as EP3 receptor antagonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 17228-64-7. Pack Sizes: 5g, 25 g. Molecular Formula: C6H6ClNO, Molecular Weight: 143.57. US Biological Life Sciences. | Worldwide |
3-(2-Chloroethyl)-6,7,8,9-tetrahydro-7-methoxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one Quick inquiry Where to buy Suppliers range | 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-7-methoxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
3-(2-Chloroethyl)-7-methoxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one Quick inquiry Where to buy Suppliers range | The compound has long-acting antipsychotic properties useful in the treatment of warm-blooded animals. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
4-Chloro-5-fluoro-2-methoxypyrimidine Quick inquiry Where to buy Suppliers range | 4-Chloro-5-fluoro-2-methoxypyrimidine. Group: Heterocyclic Organic Compound. Alternative Names: 4-CHLORO-5-FLUORO-2-METHOXYPYRIMIDINE;PyriMidine, 4-chloro-5-fluoro-2-Methoxy-. CAS No. 1801-06-5. Molecular formula: C5H4ClFN2O. Mole weight: 0. | |
5-[[2-Amino-5-[2-(4-chlorophenyl)diazenyl]-6-methoxy-4-pyrimidinyl]amino-13C2, 15N]-3- (phenylmethoxy)-2-[ (phenylmethoxy)methyl]-cyclopentanol Quick inquiry Where to buy Suppliers range | Intermediate in the synthesis of Entecavir. Group: Biochemicals. Alternative Names: (1S, 2S, 3S, 5S)-5-[[2-Amino-5-[2- (4-chlorophenyl)diazenyl]-6-methoxy-4-pyrimidinyl]amino-13C2, 15N]-3- (phenylmethoxy)-2-[ (phenylmethoxy)methyl]-cyclopentanol. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
5-[[2-Amino-5-[2- (4-chlorophenyl)diazenyl]-6-methoxy-4-pyrimidinyl]amino]-3- (phenylmethoxy)-2-[ (phenylmethoxy)methyl]-cyclopentanol Quick inquiry Where to buy Suppliers range | 5-[[2-Amino-5-[2- (4-chlorophenyl)diazenyl]-6-methoxy-4-pyrimidinyl]amino]-3- (phenylmethoxy)-2-[ (phenylmethoxy)methyl]-cyclopentanol is an intermediate in the synthesis of Entecavir (E558900). Group: Biochemicals. Alternative Names: (1S, 2S, 3S, 5S)-5-[[2-Amino-5-[2- (4-chlorophenyl)diazenyl]-6-methoxy-4-pyrimidinyl]amino]-3- (phenylmethoxy)-2-[ (phenylmethoxy)methyl]-cyclopentanol. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
5-[[2-Amino-5-[2-(4-chlorophenyl)diazenyl]-6-methoxy-4-pyrimidinyl]amino]-3-(phenylmethoxy)-2-[(phenylmethoxy)methyl]-cyclopentanol Quick inquiry Where to buy Suppliers range | 5-[[2-Amino-5-[2-(4-chlorophenyl)diazenyl]-6-methoxy-4-pyrimidinyl]amino]-3-(phenylmethoxy)-2-[(phenylmethoxy)methyl]-cyclopentanol is an intermediate in the synthesis of Entecavir. Synonyms: (1S,2S,3S,5S)-5-[[2-Amino-5-[2-(4-chlorophenyl)diazenyl]-6-methoxy-4-pyrimidinyl]amino]-3-(phenylmethoxy)-2-[(phenylmethoxy)methyl]-cyclopentanol. Molecular formula: C31H33ClN6O4. Mole weight: 589.08. | |
7-[3,5-Bis-O-[(2,4-dichlorophenyl)methyl]-2-C-methyl-beta-D-ribofuranosyl]-4-chloro-5-methyl-7H-pyrrolo[2,3-d]pyrimidine Quick inquiry Where to buy Suppliers range | 7-[3,5-Bis-O-[(2,4-dichlorophenyl)methyl]-2-C-methyl-beta-D-ribofuranosyl]-4-chloro-5-methyl-7H-pyrrolo[2,3-d]pyrimidine, a highly intricate and dynamic compound, exhibits remarkable antiviral properties. This remarkable pharmaceutical marvel has been harnessed specifically for combating viral infections, offering a powerful mechanism of action that disrupts viral replication by precisely targeting crucial enzymes involved in viral DNA synthesis. Synonyms: (3R,4R,5R)-2-(4-chloro-5-methylpyrrolo[2,3-d]pyrimidin-7-yl)-4-[(2,4-dichlorophenyl)methoxy]-5-[(2,4-dichlorophenyl)methoxymethyl]-3-methyloxolan-3-ol;NU008035;443642-54-4. Grades: 95%. CAS No. 443642-54-4. Molecular formula: C27H24Cl5N3O4. Mole weight: 631.76. | |
ALK inhibitor 2 Quick inquiry Where to buy Suppliers range | ALK inhibitor 2 is a novel and selective inhibitor for the ALK kinase. Synonyms: Benzenesulfonamide, 2-[[5-chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methyl-. Grades: >98%. CAS No. 761438-38-4. Molecular formula: C23H28ClN7O3S. Mole weight: 518.03. | |
BI-3812 Quick inquiry Where to buy Suppliers range | BI-3812 is potent and efficacious BCL6 inhibitor. It inhibits the BTB domain of BCL6 with an IC50 of ≤3 nM. The high potency and good permeability properties of BI-3812 make this molecule a very good cellular probe compound for testing hypotheses around BCL6 biology. The transcription factor BCL6 is a known driver of oncogenesis in lymphoid malignancies, including diffuse large B cell lymphoma (DLBCL). Synonyms: BI-3812; 2166387-64-8; CHEMBL4755229; 1-(5-chloro-4-((8-methoxy-1-methyl-3-(2-(methylamino)-2-oxoethoxy)-2-oxo-1,2-dihydroquinolin-6-yl)amino)pyrimidin-2-yl)-N,N-dimethylpiperidine-4-carboxamide; SCHEMBL20284237; AMY16876; BCP31903; EX-A2841; BDBM50546197; s8735; AKOS040741329; SB40386; BI 3812; BI3812; AC-31571; MS-30157; HY-111381; CS-0040299; A935150; EN300-22885148; Z3417458909; 1-[5-chloro-4-({8-methoxy-1-methyl-3-[(methylcarbamoyl)methoxy]-2-oxo-1,2-dihydroquinolin-6-yl}amino)pyrimidin-2-yl]-N,N-dimethylpiperidine-4-carboxamide; 1-[5-Chloro-4-({8-methoxy-1-methyl-3-[2-(methylamino)-2-oxoethoxy]-2-oxo-1,2-dihydro-6-quinolinyl}amino)-2-pyrimidinyl]-N,N-dimethyl-4-piperidinecarboxamide; 1-[5-chloro-4-[[8-methoxy-1-methyl-3-[2-(methylamino)-2-oxoethoxy]-2-oxoquinolin-6-yl]amino]pyrimidin-2-yl]-N,N-dimethylpiperidine-4-carboxamide. Grades: ≥98%. CAS No. 2166387-64-8. Molecular formula: C26H32ClN7O5. Mole weight: 558.03. | |
BIS(4-METHOXY-2-NITROPHENYL)DISELENIDE Quick inquiry Where to buy Suppliers range | Bis(4-methoxy-2-nitrophenyl)diselenide, 35350-45-9, 1,2-bis(4-methoxy-2-nitrophenyl)diselane, 4-methoxy-1-[(4-methoxy-2-nitrophenyl)diselanyl]-2-nitrobenzene, DTXSID30369930, MFCD00775972, AKOS001021074, FT-0761213, BIS-(4-METHOXY-2-NITROPHENYL)DISELENIDE, Z56794904, F0400-0032, 3-Chloro-6-(2-hydroxy-ethyl)-pyrazolo[1,5-a]-pyrimidine-2-carboxylicacid. | |
CEP-28122 Quick inquiry Where to buy Suppliers range | CEP-28122 is a highly potent and selective oral anaplastic lymphoma kinase inhibitor with antitumor activity in experimental human cancer models. Synonyms: CEP 28122; CEP28122; Bicyclo[2.2.1]hept-5-ene-2-carboxamide, 3-[[5-chloro-2-[[(7S)-6,7,8,9-tetrahydro-1-methoxy-7-(4-morpholinyl)-5H-benzocyclohepten-2-yl]amino]-4-pyrimidinyl]amino]-, (1S,2S,3R,4R)-; (1S,2S,3R,4R)-3-[[5-Chloro-2-[[(7S)-6,7,8,9-tetrahydro-1-methoxy-7-(4-morpholinyl)-5H-benzocyclohepten-2-yl]amino]-4-pyrimidinyl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxamide. Grades: ≥95%. CAS No. 1022958-60-6. Molecular formula: C28H35ClN6O3. Mole weight: 539.07. | |
Chlorimuron-ethyl D5 (ethyl D5) Quick inquiry Where to buy Suppliers range | Chlorimuron-ethyl D5 (ethyl D5). Uses: For analytical and research use. Group: Pesticides & Metabolites; Pesticides & Metabolites. Alternative Names: Chlorimuron-ethyl D5 (ethyl D5),Chlorimuron-ethyl D5 (Ethyl D5). IUPAC Name: 1,1,2,2,2-pentadeuterioethyl 2-[(4-chloro-6-methoxy-pyrimidin-2-yl)carbamoylsulfamoyl]benzoate. Molecular formula: C152H5H10ClN4O6S. Mole weight: 419.85. Catalog: APS006693. SMILES: [2H]C ([2H]) ([2H])C ([2H]) ([2H])OC (=O)c1ccccc1S (=O) (=O)NC (=O)Nc2nc (Cl)cc (OC)n2. Format: Neat. Product Type: Stable Isotope Labelled. | |
GW 803430 Quick inquiry Where to buy Suppliers range | GW 803430 is a potent and selective melanin-concentrating hormone receptor 1 (MCH1) antagonist (IC50 = 9.3 nM). GW 803430 exhibits antiobesity and antidepressant-like effects in rats and mice. Synonyms: GW-803430; GW 803430; GW803430. 6-(4-Chlorophenyl)-3-[3-methoxy-4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-thieno[3,2-d]pyrimidin-4(3H)-one. Grades: ≥99% by HPLC. CAS No. 515141-51-2. Molecular formula: C25H24ClN3O3S. Mole weight: 481.99. | |
MIK665 Quick inquiry Where to buy Suppliers range | MIK665 is an inhibitor of induced myeloid leukemia cell differentiation protein Mcl-1 with potential pro-apoptotic and antineoplastic activities. Synonyms: MIK-665; MIK 665; S64315; 2-[5-[3-chloro-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl]oxy-3-[2-[[2-(2-methoxyphenyl)pyrimidin-4-yl]methoxy]phenyl]propanoic acid. CAS No. 1799631-75-6. Molecular formula: C47H44ClFN6O6S. Mole weight: 875.41. | |
Mirk-IN-1 Quick inquiry Where to buy Suppliers range | Mirk-IN-1, a pyrido[2,3-d]pyrimidine derivative, has been found to be a DYRK1A/B inhibitor and probably have antitumor activity through influencing the accumulation and induce the DNA damage and apoptosis of Panc1 in tumor cells. IC50: 68±48/22±8 nM (Dyrk. Uses: Mirk-in-1 has been found to be a dyrk1a/b inhibitor and probably have antitumor activity through influencing the accumulation and induce the dna damage and apoptosis of panc1 in tumor cells. Synonyms: Dyrk1B/1A-IN-9; Dyrk1B inhibitor; 1A-IN-9; Dyrk-1B/1A-IN-9; Dyrk 1B/1A IN 9; Dyrk1B/1A-inhibitor-9; Mirk-IN-1; CHEMBL3094448; SCHEMBL10446906; CQKBSRPVZZLCJE-UHFFFAOYSA-N; BDBM50444379; AKOS025147328; N-[2-chloro-5-[(3-chlorophenyl)methylcarbamoyl]phenyl]-2-methoxy-7-oxo-8H-pyrido[2,3-d]pyrimidine-6-carboxamide. Grades: 98%. CAS No. 1386979-55-0. Molecular formula: C23H17Cl2N5O4. Mole weight: 498.32. | |
Moxonidine Quick inquiry Where to buy Suppliers range | Moxonidine is an antihypertensive agent. Group: Biochemicals. Alternative Names: 4-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methyl-5-pyrimidinamine; 2-(6-Chloro-4-methoxy-2-methylpyrimidin-5-ylamino)-2-imidazoline; Lomox; Moxon; Norcynt; Normoxocin; Nucynt; Physiotens. Grades: Highly Purified. CAS No. 75438-57-2. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
Moxonidine Quick inquiry Where to buy Suppliers range | Moxonidine is a selective agonist at the imidazoline receptor subtype (I1). It binds with much greater affinity to the imidazoline I1-receptor than to the α2-receptor while clonidine binds to both receptors with equal affinity. Uses: Antihypertensive agents. Synonyms: 4-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methyl-5-pyrimidinamine; 2-(6-Chloro-4-methoxy-2-methylpyrimidin-5-ylamino)-2-imidazoline; Lomox; Moxon; Norcynt; Normoxocin; Nucynt; Physiotens. Grades: >98%. CAS No. 75438-57-2. Molecular formula: C9H12ClN5O. Mole weight: 241.68. | |
MRTX849 Quick inquiry Where to buy Suppliers range | MRTX849 is a potent and mutation-selective covalent inhibitor of KRAS G12C. It maximizes inhibition by irreversibly locking the KRAS molecule in its inactive state, thereby preventing tumor cell growth which results in tumor cell death. Uses: Antineoplastic agents. Synonyms: MRTX-849; MRTX 849; Adagrasib; 2-((S)-4-(7-(8-Chloronaphthalen-1-yl)-2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-1-(2-fluoroacryloyl)piperazin-2-yl)acetonitrile. CAS No. 2326521-71-3. Molecular formula: C32H35ClFN7O2. Mole weight: 604.12. | |
Quinine Quick inquiry Where to buy Suppliers range | Quinine. Uses: Quinine occurs in the dried stems or rootbarks of cinchona (Cinchona ledgerianaMoens). It is used in the treatment of malaria.It is also used as an analgesic and antipyreticagent.A quinolinemethanol from the bark of the Cinchona tree; the laevorotatory stereoisomer of quinidine. Formulated as the sulfate, bisulfate or ethylcarbonate for oral use and as the dihydrochloride for parenteral administration. The salts are highly soluble in water.Falciparum malaria (alone or in combination with tetracycline, doxycycline, clindamycin or pyrimethamine-sulfadoxine) Babesiosis (in combination with clindamycin) It is particularly used in cerebral malaria if chloroquine resistance is suspected (Ch. 62). It is not recommended for treatment of uncomplicated falciparum malaria. Alternative Names: ZINC3831404; Coco-Quinine; UNII-A7V27PHC7A; Quinine sulphate; 6-Methoxycinchonine; Quinine tannate; SC-00760; Quinine, 90%; ACN-048717; (R)-(6-methoxy-4-quinolyl)-[(2S,4S,5R)-5-vinylquinuclidin-2-yl]methanol. CAS No. 130-95-0. Molecular formula: C20H24O2N2;C20H24N2O2. Mole weight: 324.424g/mol. IUPAC Name: (R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol. Rotatable Bond Count: 4. Exact Mass: 324.184g/mol. EC Number: 205-003-2. Melting Point: 177 deg C (some decomposition);57°C. Solubility: In water, 500 mg/L at 15 deg C;1 g dissolves in: 1900 mL water, 760 mL boiling water;1 g dissolves in: 80 mL benzene (18 mL at 50 deg C), 1.2 mL chloroform, 250 mL dry ether, 20 mL glycerol, 0.8 mL alcohol, 1900 mL of 10% ammonia water; almost insoluble in petroleum ether;Soluble in ether, chloroform, carbon disulfide, glycerol, alkalies, and acids (with formation of salts);Sol in pyrimidine;3.34e-01 g/L. SMILES: COC1=CC2=C (C=CN=C2C=C1)C (C3CC4CCN3CC4C=C)O. InChI: InChI=1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13-,14-,19-,20+/m0/s1. InChIKey: LOUPRKONTZGTKE-WZBLMQSHSA-N. H-Bond Donor: 1. H-Bond Acceptor: 4. Monoisotopic Mass: 324.184g/mol. | |
S-63845 Quick inquiry Where to buy Suppliers range | S-63845 is a selective inhibitor of MCL1 (Ki (MCL1, FP) < 1.2 nM; Kd (MCL1, SPR) = 0.19 nM; Ki (BCL2, FP)> 10.000 1.2 nM; Ki (BCL-XL, FP) > 10.000 1.2 nM). It has high affinity for the BH3-binding groove of MCL1. Study in vitro showed that S63845 could kill MCL1-dependent cancer cells; Study in vivo indicated that its potent antineoplastic activity and with an acceptable safety margin in different cancers. S63845 is promisingly to be an antineoplastic drug of various cancers. Uses: Antineoplastic drug. Synonyms: S63845; S-63845; S 63845. (R)-2-((5-(3-chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(5-fluorofuran-2-yl)thieno[2,3-d]pyrimidin-4-yl)oxy)-3-(2-((1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)methoxy)phenyl)propanoic acid. CAS No. 1799633-27-4. Molecular formula: C39H37ClF4N6O6S. Mole weight: 829.2646. | |
TAE 684 Quick inquiry Where to buy Suppliers range | TAE 684. Group: Biochemicals. Alternative Names: NVP-TAE 684; NVT TAE-684; 5-Chloro-N2-[2-methoxy-4-[4- (4-methyl-1-piperazinyl) -1-piperidinyl]phenyl]-N4-[2-[ (1-methylethyl) sulfonyl]phenyl]-2, 4-pyrimidinediamine. Grades: Highly Purified. CAS No. 761439-42-3. Pack Sizes: 10mg. Molecular Formula: C30H40ClN7O3S, Molecular Weight: 614.2. US Biological Life Sciences. | Worldwide |
TAE 684 Quick inquiry Where to buy Suppliers range | TAE 684. Uses: For analytical and research use. Group: Enzyme Activators, Inhibitors & Substrates. Alternative Names: 5-Chloro-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-2,4-pyrimidinediamine, NVT TAE-684, TAE 684, AE 684, NVP-TAE 684. CAS No. 761439-42-3. IUPAC Name: 5-chloro-2-N-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine. Molecular formula: C30H40ClN7O3S. Mole weight: 614.20. Catalog: APS761439423. SMILES: COc1cc (ccc1Nc2ncc (Cl)c (Nc3ccccc3S (=O) (=O)C (C)C)n2)N4CCC (CC4)N5CCN (C)CC5. Format: Neat. | |
WZ-4002 Quick inquiry Where to buy Suppliers range | WZ-4002 is an EGFR phosphorylation inhibitor with selectivity for EGFR T790M. It has a framework of pyrimidine compound which is different from other EGFR inhibitors. WZ-4002 exhibits anti-tumor activity. Uses: Protein kinase inhibitors. Synonyms: WZ4002; N-(3-(5-chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide; WZ 4002. CAS No. 1213269-23-8. Molecular formula: C25H27ClN6O3. Mole weight: 494.98. | |
(Z)-Fluoxastrobin Quick inquiry Where to buy Suppliers range | (Z)-Fluoxastrobin. Uses: For analytical and research use. Group: Pesticides & Metabolites; Pharma & Vet Compounds & Metabolites; Pesticides & Metabolites. CAS No. 887973-21-9. IUPAC Name: (Z)-1-[2-[6-(2-chlorophenoxy)-5-fluoro-pyrimidin-4-yl]oxyphenyl]-1-(5,6-dihydro-1,4,2-dioxazin-3-yl)-N-methoxy-methanimine. Molecular formula: C21H16ClFN4O5. Mole weight: 458.83. Catalog: APS887973219. SMILES: CO\N=C (/C1=NOCCO1)\c2ccccc2Oc3ncnc (Oc4ccccc4Cl)c3F. Format: Neat. | |
Zunsemetinib Quick inquiry Where to buy Suppliers range | Zunsemetinib is a tyrosine kinase inhibitor. Synonyms: [1(2H),4'-Bipyridin]-2-one, 3-chloro-4-[(3,5-difluoro-2-pyridinyl)methoxy]-2'-[2-(1-hydroxy-1-methylethyl)-4-pyrimidinyl]-5',6-dimethyl-, (-)-. Grades: >98%. CAS No. 1640282-42-3. Molecular formula: C25H22ClF2N5O3. Mole weight: 513.92. |