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| Product | Description | |
|---|---|---|
| Cholesterol acetate | Cholesterol acetate. Group: Liquid crystal (lc) building blocks. Alternative Names: Cholest-5-en-3-beta-yl acetate. CAS No. 604-35-3. Product ID: [(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate. Molecular formula: 428.69. Mole weight: C29H48O2. C[C@H] (CCCC (C)C)[C@H]1CC[C@@H]2[C@@]1 (CC[C@H]3[C@H]2CC=C4[C@@]3 (CC[C@@H] (C4)OC (=O)C)C)C. XUGISPSHIFXEHZ-VEVYEIKRSA-N. InChI=1S/C29H48O2/c1-19 (2)8-7-9-20 (3)25-12-13-26-24-11-10-22-18-23 (31-21 (4)30)14-16-28 (22, 5)27 (24)15-17-29 (25, 26)6/h10, 19-20, 23-27H, 7-9, 11-18H2, 1-6H3/t20-, 23+, 24+, 25-, 26+, 27+, 28+, 29-/m1/s1. |  |
| 20-Dehydro cholesterol 3-acetate | 20-Dehydro cholesterol 3-acetate. Group: Biochemicals. Alternative Names: (3b,20E)-Cholesta-5,20(22)-dien-3-ol 3-acetate; Cholesta-5,20(22)-dien-3b-ol acetate. Grades: Highly Purified. CAS No. 54548-85-5. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C29H46O2. US Biological Life Sciences. |  Worldwide |
| 22-Dehydro 25-Hydroxy Cholesterol 3-Acetate | Cholesterol derivative. Group: Biochemicals. Alternative Names: (3 β,22E)-Cholesta-5,22-diene-3,25-diol 3-Acetate. Grades: Highly Purified. CAS No. 157171-88-5. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| 22-Dehydro Cholesterol-d7 3-Acetate | Cholesterol derivative. Group: Biochemicals. Alternative Names: 5,22E-Cholestadien-3 β-ol-d7 Acetate; 5,22E-Cholestadien-3 β-yl-d7 Acetate; (3 β,22E)-Cholesta-5,22-dien-3-ol-d7 3-Acetate. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 4 β-Hydroxy Cholesterol 4-Acetate | Cholesterol metabolite. Hydroximinosteroid analog with cytotoxic properties. Group: Biochemicals. Alternative Names: (3 β,4 β)-Cholest-5-ene-3,4-diol 4-Acetate; 4 β-Acetoxycholest-5-en-3 β-ol. Grades: Highly Purified. CAS No. 2515-18-6. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 4 β-Hydroxy Cholesterol-d7 4-Acetate | Labeled Cholesterol metabolite. Hydroximinosteroid analog with cytotoxic properties. Group: Biochemicals. Alternative Names: (3 β,4 β)-Cholest-5-ene-3,4-diol-d7 4-Acetate; 4 β-Acetoxycholest-5-en-3 β-ol-d7. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 4b-Hydroxy cholesterol 4-acetate | 4b-Hydroxy cholesterol 4-acetate. Group: Biochemicals. Alternative Names: (3b,4b)-Cholest-5-ene-3,4-diol 4-acetate; 4b-Acetoxycholest-5-en-3b-ol. Grades: Highly Purified. CAS No. 2515-18-6. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C29H48O3. US Biological Life Sciences. | Worldwide |
| 7 β-Hydroxy Cholesterol 3 β-Acetate | Intermediate in the preparation of Cholesterol metabolites. Group: Biochemicals. Alternative Names: 7 β-Hydroxycholesteryl 3 β-Acetate. Grades: Highly Purified. CAS No. 17974-77-5. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| 7b-Hydroxy cholesterol 3b-acetate | 7b-Hydroxy cholesterol 3b-acetate. Group: Biochemicals. Alternative Names: 7b-Hydroxycholesteryl 3b-acetate. Grades: Highly Purified. CAS No. 17974-77-5. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C29H48O3. US Biological Life Sciences. | Worldwide |
| 7-Oxo Cholesterol 3-Acetate | Intermediate in the preparation of various Cholesterol derivatives and metabolites. Group: Biochemicals. Alternative Names: (3 β)-3-(Acetyloxy)cholest-5-en-7-one; 3 β-Hydroxy-cholest-5-en-7-one Acetate; 7-Ketocholesteryl Acetate; 7-Oxocholest-5-en-3 β-yl Acetate; 7-Oxocholesteryl Acetate; NSC 59469. Grades: Highly Purified. CAS No. 809-51-8. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 7-Oxo Cholesterol-d7 3-Acetate | Intermediate in the preparation of various Cholesterol derivatives and metabolites. Group: Biochemicals. Alternative Names: (3 β)-3-(Acetyloxy)cholest-5-en-7-one-d7; 3 β-Hydroxy-cholest-5-en-7-one-d7 Acetate; 7-Ketocholesteryl-d7 Acetate; 7-Oxocholest-5-en-3 β-yl-d7 Acetate; 7-Oxocholesteryl-d7 Acetate; NSC 59469-d7. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| 7-p-Toluene sulfonylhydrazide Cholesterol 3-Acetate | Cholesterol derivative. Used in the preparation of 5,7-diene steroids. Group: Biochemicals. Alternative Names: 4-Methyl-benzenesulfonic Acid 2-[(3 β)-3-(Acetyloxy)cholest-5-en-7-ylidene]hydrazide; p-Toluenesulfonic Acid (3 β-Hydroxycholest-5-en-7-ylidene)hydrazide Acetate. Grades: Highly Purified. CAS No. 54201-67-1. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 7-p-Toluene sulfonylhydrazide Cholesterol-d7 3-Acetate | Labeled Cholesterol derivative. Used in the preparation of 5,7-diene steroids. Group: Biochemicals. Alternative Names: 4-Methyl-benzenesulfonic Acid 2-[(3 β)-3-(Acetyloxy)cholest-5-en-7-ylidene]hydrazide-d7; p-Toluenesulfonic Acid (3 β-Hydroxycholest-5-en-7-ylidene)hydrazide-d7 Acetate. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Cholesterol 3-Acetate-d7 | Isotope labelled Cholesterol 3-Acetate-d7 is an derivative of Cholesterol (C432501), a major component of all biological membranes. Group: Biochemicals. Alternative Names: (-)-Cholesteryl Acetate-d7; (3 β)-Cholest-5-en-3-ol Acetate-d7; 3-Cholesteryl Acetate-d7; 3 β-Acetoxycholest-5-ene-d7; Cholest-5-en-3 β-ol Acetate-d7; Cholest-5-en-3 β-yl Acetate-d7; Cholesterin Acetate-d7; Cholesterol 3-Acetate-d7; Cholesterol 3 β-Acetate-d7; Cholesteryl Acetate-d7; NSC 8799. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| 19-Hydroxy Cholesteryl 3-Acetate | A C-19 functionalized cholesterol derivative and popular substrate for steroid biotransformations. Group: Biochemicals. Alternative Names: (3 β)-Cholest-5-ene-3,19-diol 3-Acetate; 3 β-Acetoxycholest-5-en-19-ol; 19-Hydroxycholesterol 3-Acetate; 19-Hydroxycholesterol Acetate; NSC 123342. Grades: Highly Purified. CAS No. 750-59-4. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| (22S)-22-Hydroxycholest-5-en-3 β-yl Acetate | (22S)-22-Hydroxycholest-5-en-3 β-yl Acetate is an intermediate in the synthesis of 22S-metabolite of Cholesterol (C432501). Group: Biochemicals. Grades: Highly Purified. CAS No. 54604-57-8. Pack Sizes: 5mg, 50mg. Molecular Formula: C29H48O3. US Biological Life Sciences. | Worldwide |
| 3-O-Acetyl-26-hydroxy Cholesterol | Intermediate in the production of cholesterol metabolites. Group: Biochemicals. Alternative Names: Cholest-5-ene-3 β,26-diol 3-acetate; (3 β)-Cholest-5-ene-3,26-diol 3-Acetate. Grades: Highly Purified. CAS No. 50681-37-3. Pack Sizes: 2mg. US Biological Life Sciences. | Worldwide |
| 3-O-Acetyl Ezetimibe 2,3,4-Tri-O-acetyl- β-D-glucuronide Methyl Ester | Intermediate in the preparation of Phase-II metabolites of Ezetimibe. Glucuronide azetidinone cholesterol absorption inhibitor. Group: Biochemicals. Alternative Names: 4-[(2S,3R)-3-[(3S)-3-(Acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-fluorophenyl)-4-oxo-2-azetidinyl]phenyl β-D-Glucopyranosiduronic Acid Methyl Ester 2,3,4-Triacetate. Grades: Highly Purified. CAS No. 190448-56-7. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 3-O-Acetyl Ezetimibe-d4 2,3,4-Tri-O-acetyl- β-D-glucuronide Methyl Ester | Labeled intermediate in the preparation of Phase-II metabolites of Ezetimibe. Glucuronide azetidinone cholesterol absorption inhibitor. Group: Biochemicals. Alternative Names: 4-[(2S,3R)-3-[(3S)-3-(Acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-fluorophenyl-d4)-4-oxo-2-azetidinyl]phenyl β-D-Glucopyranosiduronic Acid Methyl Ester 2,3,4-Triacetate. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Acetyl coenzyme A | Acetyl coenzyme A is the precursor to HMG CoA, an essential component in the synthesis of cholesterol and ketone. Synonyms: Acetyl-CoA; S-Acetyl coenzyme A; AcCoA; Coenzyme A, S-acetate; S-acetyl-CoA. CAS No. 72-89-9. Molecular formula: C23H38N7O17P3S. Mole weight: 809.57. |  |
| AS-186c | AS-186c is an acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor produced by Penicillum asperosporum KY1635. The IC50 for inhibiting ACAT was 11.5 μmol/L. Synonyms: 1-(7-{2-[2,6-dihydroxy-3-(3-methylbut-2-en-1-yl)benzoyl]-3-hydroxy-5-methylphenyl}-8,12-dihydroxy-4-methoxy-10-methyl-5-oxo-7,8-dihydro-5H-dibenzo[b,h][1,5]dioxonin-3-yl)-3-methylbutyl acetate. Molecular formula: C43H46O12. Mole weight: 754.82. | |
| AS-186d | AS-186d is an acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor produced by Penicillum asperosporum KY1635. The IC50 for inhibiting ACAT was 12.4 μmol/L. Synonyms: 1-(8,12-dihydroxy-7-{3-hydroxy-2-[6-hydroxy-3-(1-hydroxy-3-methylbutyl)-2-methoxybenzoyl]-5-methylphenyl}-4-methoxy-10-methyl-5-oxo-7,8-dihydro-5H-dibenzo[b,h][1,5]dioxonin-3-yl)-3-methylbutyl acetate. Molecular formula: C44H50O13. Mole weight: 786.86. | |
| Cholesteryl acetate | Cholesteryl acetate (Cholesterol 3-acetate) is a cholesterol ester [1]. Uses: Scientific research. Group: Natural products. Alternative Names: Cholesterol 3-acetate; Cholesterin acetate; Cholesterol 3β-acetate. CAS No. 604-35-3. Pack Sizes: 50 mg; 100 mg. Product ID: HY-107823. |  |
| Cholesteryl acetate | Cholesteryl acetate - Product ID: NST-10-92. Category: Sterols. Alternative Names: Acebrochol, Cholesterol, Cholesterin. Purity: 98%. Test method: HPLC. CAS No. 604-35-3. Pack Sizes: 5g, 10g, 25g, 50g. Appearance: White to beige colored powder. Molecular formula: C29H48O2. Mole weight: 428.7. Storage: +2 +8 °C. |  |
| Cholesteryl Acetate | Cholesterol is a major component of all biological membranes; Cholesterol was found in all body tissues, especial in the brain, spinal cord, and in animal fats or oils. Group: Liquid crystal (lc) materials. Alternative Names: 3β-Acetoxy-5-cholestene. CAS No. 604-35-3. Pack Sizes: 25 kg/DRUMS. Product ID: [(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate. Molecular formula: 428.69. Mole weight: C29H48O2. XUGISPSHIFXEHZ-VEVYEIKRSA-N. 95%. | |
| Cholesteryl Acetate | Cholesterol is a major component of all biological membranes; Cholesterol was found in all body tissues, especial in the brain, spinal cord, and in animal fats or oils. Group: Organic & printed electronicscholesteryl esters. Alternative Names: 3β-Acetoxy-5-cholestene. CAS No. 604-35-3. Molecular formula: C29H48O2. Mole weight: 428.69. Appearance: White fine crystalline powder or needles. Purity: 0.95. IUPACName: [(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate. Density: 0.99 g/cm³. Catalog: ACM604353. |  |
| FR901512 | FR901512, a new specific inhibitor of HMG-CoA reductase, is isolated from the culture of an agonomycetous fungus No. 14919. FR901512 inhibits cholesterol synthesis from [14C] acetate in Hep G2 cells. Synonyms: 6-Heptenoic acid, 7-[(6R,8S)-8-(acetyloxy)-5,6,7,8-tetrahydro-2,6-dimethyl-1-naphthalenyl]-3,5-dihydroxy-, (3R,5S,6E)-; (3R,5S,E)-7-((6R,8S)-8-acetoxy-2,6-dimethyl-5,6,7,8-tetrahydronaphthalen-1-yl)-3,5-dihydroxyhept-6-enoic acid. CAS No. 151606-25-6. Molecular formula: C21H28O6. Mole weight: 376.44. | |
| Lapaquistat acetate | Lapaquistat acetate, also referred as TAK475, is a squalene synthase inhibitor. As a cholesterol-lowering drug, Lapaquistat acetate decreased plasma cholesterol and triglyceride levels, by lowering lipoproteins containing apoB100. Uses: A novel squalene synthase inhibitor. Synonyms: 2-[1-[2-[(3R,5S)-1-(3-acetyloxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-5H-4,1-benzoxazepin-3-yl]acetyl]piperidin-4-yl]acetic acid; (1-(2-(1-(2-carboxyoxy-1,1-dimethylethyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydrobenzo(e)(1,4)oxazepin-3-yl)acetyl)piperidin-4-yl)acetic acid; 1-((1-(3-acetoxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl)acetyl)piperidine-4-acetic acid; lapaquistat; TAK 475; TAK-475; TAK475. Grades: >98%. CAS No. 189060-13-7. Molecular formula: C33H41ClN2O9. Mole weight: 645.14. | |
| Native Clostridium tetani Tetanolysin | Tetanolysin is a toxin produced by Clostridium tetani bacteria. Its function is unknown but it is believed to contribute to the pathogenesis of tetanus. The other C. tetani toxin, tetanospasmin, is more definitively linked to tetanus. Tetanolysin belongs to a family of protein toxins known as cytolysins which bind to cholesterol. Cytolysins form pores in the cytoplasmic membrane that allows for the passage of ions and other molecules into the cell. The molecular weight of tetanolysin is approximately 55 kDa daltons. Hemolytic activity of tetanolysin is determined using 2.5% rabbit red blood cells at 37°c for 40 min. Applications: Tetanolysin has been used to analyze the formation of lytic pores in red blood cells (rbcs). it has also been used to permeabilize infected rbcs. Group: Others. Synonyms: Tetanolysin. Mole weight: 55 kDa. Storage: 2-8°C. Form: lyophilized powder containing sodium chloride and sodium acetate. Source: Clostridium tetani. Tetanolysin. Cat No: NATE-0693. |  |
| Purpactin B | Purpactin B is a cholesterol acyltransferase (ACAT) inhibitor produced by Pen. purpurogenum FO-6. Synonyms: 1-[2'-(hydroxymethyl)-4-methoxy-4'-methyl-3,6'-dioxo-3h-spiro[1-benzofuran-2,1'-cyclohexa[2,4]dien]-5-yl]-3-methylbutyl acetate. CAS No. 133806-60-7. Molecular formula: C23H26O7. Mole weight: 414.45. | |
| Pyripyropene A | Pyripyropene A is a powerful acyl-CoA: cholesterol acyltransferase 2 (ACAT2) inhibitor produced by the fungus Aspergillus fumigatus FO 1289. It inhibits acyl-CoA: cholesterol acyltransferase with an IC50 of 58 nmol/L. Synonyms: (3S,4R,4aR,6S,6aS,12R,12aS,12bS)-4-(acetoxymethyl)-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-benzo[f]pyrano[4,3-b]chromene-3,6-diyl diacetate; (3S,4R,4aR,6S,6aS,12R,12aS,12bS)-4-(Acetoxymethyl)-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,2,3,4,4a,5,6,6a,11,12,12a,12b-dodecahydrobenzo[f]pyrano[4,3-b]chromene-3,6-diyl diacetate. Grades: ≥95%. CAS No. 147444-03-9. Molecular formula: C31H37NO10. Mole weight: 583.62. | |
| Simvastatin EP Impurity B | An impurity of Simvastatin. Simvastatin is a lipid-lowering drug that inhibits HMG-CoA reductase. It is in the statin class of medications and works by decreasing the manufacture of cholesterol by the liver. Synonyms: Acetyl simvastatin; 4'-Acetyl Simvastatin; Simvastatin Acetate; Simvastatin acetate ester; Simvastatin USP Related Compound B. Grades: 95%. CAS No. 145576-25-6. Molecular formula: C27H40O6. Mole weight: 460.62. | |
| 1-[(3 β,7α)-3-(Acetyloxy)cholesta-5,8-dien-7-yl]-1,2-hydrazinedicarboxylic Acid 1,2-Diisoprpyl Ester | 1-[(3 β,7α)-3-(Acetyloxy)cholesta-5,8-dien-7-yl]-1,2-hydrazinedicarboxylic Acid 1,2-Diisoprpyl Ester is an intermediate in the synthesis of Zymostenol, which is the derivative of Zymosterol (Z701520), an sterol intermediate in the biosynthesis of cholesterol (C432501). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 50mg, 100mg. Molecular Formula: C37H60N2O6. US Biological Life Sciences. | Worldwide |
| 2- (Acetyloxy) -1-[3, 5-dimethoxy-4- (benzoyloxy) phenyl]ethanone | 2- (Acetyloxy) -1-[3, 5-dimethoxy-4- (benzoyloxy) phenyl]ethanone is an intermediate in the synthesis of Hirsutidin Chloride (H356800), which is an anthocyanidin found in the Madagascar Periwinkle (Catharanthus Roseus). Hirsutidin Chloride can be used in the preparation of plant based compounds to lower LDL cholesterol. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 10mg. Molecular Formula: C19H18O7, Molecular Weight: 358.34. US Biological Life Sciences. | Worldwide |
| 2- (tert-Butoxycarbonyl oxyimino) phenyl acetonitri le | 2- (tert-Butoxycarbonyl oxyimino) phenyl acetonitri le is used as a reagent in the synthesis of phosphono methyl ornithine. Also used in the preparation of cholesterol-tagged natural fusion-protein-derived peptides with potent antiviral activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 58632-95-4. Pack Sizes: 5g, 10g. Molecular Formula: C13H14N2O3. US Biological Life Sciences. | Worldwide |
| 3-O-Acetyl Ezetimibe | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L4) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (3R,4S)- 3-[(3S)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-fluorophenyl)-4-(4-hydroxyphenyl)-2-Azetidinone. Grades: > 95%. CAS No. 190448-46-5. Molecular formula: C26H23F2NO4. Mole weight: 451.47. | |
| 5α-Bromo-6,19-epoxycholestanol 3-Acetate | Intermediate in the chemical synthesis of cholesterol derivatives, and substrate for producing androsterone derivatives via bacterial steroid biotransformation. Group: Biochemicals. Alternative Names: (3 β,5α,6 β)-. Grades: Highly Purified. CAS No. 1258-07-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 5-Bromo-5α-cholestane-3,6-diol 3-Acetate | Intermediate in the production of cholesterol derivatives. Group: Biochemicals. Alternative Names: 3 β-Acetoxy-5-bromo-5α-cholestan-6 β-ol. Grades: Highly Purified. CAS No. 1258-35-1. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Acetyl-Coenzyme A acetyltransferase 2 from Human, Recombinant | ACAT2 enzyme participates in lipid metabolism. ACAT2 takes part in lipoprotein assembly, catalyzing cholesterol esterification in mammalian cells. ACAT2 is an integral membrane protein that localizes to the endoplasmic reticulum of human intestinal cells. ACAT2 deficiency contributes to severe mental retardation and hypotonus. Acat2 recombinant human produced in e. coli is a single, non-glycosylated polypeptide chain containing 433 amino acids (1-397 a.a.) and having a molecular mass of 45.4 kda. the acat2 is fused to 36 amino acid his-tag at n-terminus and purified by proprietary chromatographic techniques. Group: Enzymes. Synonyms: Acetyl-CoA acetyltransferase cytosolic; Cytosolic acetoacetyl-CoA thiolase; ACAT2; Acetyl CoA transferase-like protein; ACAT-2. Purity: Greater than 95.0% as determined by SDS-PAGE. ACAT-2. Mole weight: 45.4 kDa. Stability: ACAT2 Human although stable at 4°C for 1 week, should be stored desiccated below -18°C. Please prevent freeze thaw cycles. Appearance: Sterile Filtered clear solution. Source: E. coli. Species: Human. Acetyl-CoA acetyltransferase cytosolic; Cytosolic acetoacetyl-CoA thiolase; ACAT2; Acetyl CoA transferase-like protein; ACAT-2. Cat No: NATE-0798. | |
| Acetyl coenzyme A sodium salt | Acetyl coenzyme A sodium salt, a pivotal molecule in the biomedical industry, is widely utilized in fatty acid and cholesterol biosynthesis, as well as the citric acid cycle. Its role in drug and toxin metabolism and breakdown in the body is also noteworthy. Besides, it contributes to treating metabolic disorders such as diabetes, obesity, and cancer. Its multifaceted functions make it a molecule of great scientific significance. Synonyms: Acetyl CoA. Grades: 90%. CAS No. 102029-73-2. Molecular formula: C23H38N7O17P3S·xNa. Mole weight: 809.57 (free acid). | |
| Berberine chloride hydrate | The plant-based alkaloid berberine has potential therapeutic applications for breast cancer, although a better understanding of the genes and cellular pathways regulated by this compound is needed to define the mechanism of its action in cancer treatment. In this review, the molecular targets of berberine in various cancers, particularly breast cancer, are discussed. Berberine was shown to be effective in inhibiting cell proliferation and promoting apoptosis in various cancerous cells. Some signaling pathways affected by berberine, including the MAP (mitogen-activated protein) kinase and Wnt/β-catenin pathways, are critical for reducing cellular migration and sensitivity to various growth factors. Treatment with BBR(Berberine) in rats on the atherogenic diet reduced plasma total cholesterol and nonHDL cholesterol levels by 29%-33% and 31%-41%, respectively, with no significant differences being observed among the three doses. Berberine induced both apoptotic and autophagic death of HepG2 cells, which was associated with a significant activation of AMPK and an increased expression of the inactive form of acetyl-CoA carboxylase (ACC). Berberine did not show major effects on viability of HEK-293 embryonic kidney and HCT116 colon carcinoma cells and was not toxic in concentrations up to 20 μM. Berberine inhibited β-catenin transcriptional activity and attenuated anchorage-independent growth. As a result of berberine treatment, cellular levels of active β-catenin were reduced concomitant with an increase in the expression of E-cadherin. Synonyms: Natural Yellow 18. Grades: >98%. CAS No. 141433-60-5. Molecular formula: C20H18ClNO4. Mole weight: 371.81. | |
| Cancer Hydrolase KIAA1363 Inhibitor, JW480 (2-Isopropylphenyl-2- (2-naphthyl) ethylcarbamate, AADACL1 Inhibitor, Arylacetamide Deacetylase-Like 1 Inhibitor, NCEH1 Inhibitor, Neutral Cholesterol Ester Hydrolase 1 Inhibitor) | A membrane-permeable, highly potent and selective inhibitor against the 2-acetyl MAGE (monoakylglycerol ether) hydrolase KIAA1363/AADACL1 of both human (IC50=12nM; PC3 lysate) and murine (IC50=20nM; brain membrane samples) origin, with no significant effect toward other PC3 or murine brain serine hydrolase activities, including HSL, FAAH, and AChE. Readily crosses blood-brain barrier in mice and effectively suppresses PC3-derived tumor growth in mice in vivo (by 56% on day 33; 80mg/kg/day; o.g.). Also inhibits blood carboxylesterase. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Cholesterol myristate | Cholesterol myristate is a natural steroid present in traditional Chinese medicine. Cholesterol myristate binds to several ion channels such as the nicotinic acetylcholine receptor , GABAA receptor , and the inward-rectifier potassium ion channel. Uses: Scientific research. Group: Natural products. Alternative Names: Cholesteryl myristate; Cholesteryl tetradecanoate. CAS No. 1989-52-2. Pack Sizes: 500 mg; 1 g. Product ID: HY-N2338. | |
| Ezetimibe Diacetate | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L5) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (3R,4S)-3-[(3S)-3-(Acetyloxy)-3-(4-fluorophenyl)propyl]-4-[4-(acetyloxy)phenyl]-1-(4-fluorophenyl)-2-azetidinone. Grades: > 95%. CAS No. 163380-20-9. Molecular formula: C28H25F2NO5. Mole weight: 493.51. | |
| fucosterol-epoxide lyase | The insect enzyme is involved in the conversion of sitosterol into cholesterol. Group: Enzymes. Synonyms: (24R,24'R)-fucosterol-epoxide acetaldehyde-lyase; (24R,24'R)-fucosterol-epoxide acetaldehyde-lyase (desmosterol-forming). Enzyme Commission Number: EC 4.1.2.33. CAS No. 99676-42-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4870; fucosterol-epoxide lyase; EC 4.1.2.33; 99676-42-3; (24R,24'R)-fucosterol-epoxide acetaldehyde-lyase; (24R,24'R)-fucosterol-epoxide acetaldehyde-lyase (desmosterol-forming). Cat No: EXWM-4870. | |
| GW 501516 | An experimental drug meant to control lipids and increase the level of HDL, or good cholesterol, in the bloodstream. A cell-permeable, thiazolyl compound that acts as a potent, high affinity, PPARδ agonist. Exhibits selectivity for PPARδ compared to PPARα and PPARγ. Does not exibit any activity against other nuclear or non-nuclear receptors. Reported to increase cholesterol efflux and ABAC1 expression in macrophages, fibroblasts, and intestinal cells. Group: Biochemicals. Alternative Names: 2- [2-Methyl-4- [ [ [4-methyl-2- [4- (trifluoromethyl) phenyl] -5-thiazolyl] methyl] thio] phenoxy] acetic Acid; Methyl-methyl-trifluoromethylphenyl-thiazolyl-methylsulfanyl-phenoxy-acetic Acid; GW 1516; Endurobol. Grades: Highly Purified. CAS No. 317318-70-0. Pack Sizes: 10mg, 50mg. Molecular Formula: C??H??F?NO?S?, Molecular Weight: 453.5. US Biological Life Sciences. | Worldwide |
| Lalistat 1 | Lalistat 1 is a lysosomal acid lipase inhibitor with IC50 value of 68 nM. It can block LAL-mediated lipid hydrolysis of acetylated LDL and reduce efflux of cholesterol from lipid-loaded cells. Synonyms: 4-(Piperidin-1-yl)-1,2,5-thiadiazol-3-yl morpholine-4-carboxylate. Grades: ≥98% by HPLC. CAS No. 501104-16-1. Molecular formula: C12H18N4O3S. Mole weight: 298.36. | |
| Laropiprant | a drug used in combination with niacin to reduce blood cholesterol (LDL and VLDL) that is no longer sold. Uses: A potent, selective dp1 receptor antagonist. Synonyms: (3R)-4-[(4-chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro-5-(methylsulfonyl)-cyclopent[b]indole-3-acetic acid. Grades: > 95%. CAS No. 571170-77-9. Molecular formula: C21H19ClFNO4S. Mole weight: 435.91. | |
| Oleoyl coenzyme A lithium salt | Coenzyme A functions as an acyl group carrier, acetyl-CoA. Oleoyl coenzyme A (Oleoyl-CoA) may be used to study the specificity and kinetics of enzymes such as acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) involved in long chain fatty acid cholesterol esterification. Applications: May be used to study the specificity and kinetics of enzymes such as acyl-coenzyme a:cholesterol acyltransferase 1 (acat1). Group: Coenzymes. Synonyms: cis-9-Octadecenoyl coenzyme A. CAS No. 188824-37-5. Purity: ≥90%. Mole weight: 1031.98. Appearance: Powder. Form: Solid. cis-9-Octadecenoyl coenzyme A; Oleoyl coenzyme A lithium salt; 188824-37-5. Cat No: COEC-058. | |
| Palmitoyl eicosapentaenoyl Phosphatidylcholine-d9 | Palmitoyl eicosapentaenoyl Phosphatidylcholine-d9 is labelled Palmitoyl eicosapentaenoyl Phosphatidylcholine (P156900) which is a possible Cholesterol Acetyltransferase inhibitor. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C44H69D9NO8P, Molecular Weight: 789.12. US Biological Life Sciences. | Worldwide |
| Pitavastatin | Pitavastatin (NK-104) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin inhibits cholesterol synthesis from acetic acid with an IC 50 of 5.8 nM in HepG2 cells. Pitavastatin is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Pitavastatin also possesses anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective and reno-protective effects [1] [2] [3] [8]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NK-104. CAS No. 147511-69-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-B0144A. | |
| Pitavastatin Calcium | Pitavastatin Calcium (NK-104 hemicalcium) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin Calcium (NK-104 hemicalcium) inhibits cholesterol synthesis from acetic acid with an IC 50 of 5.8 nM in HepG2 cells. Pitavastatin Calcium is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Pitavastatin Calcium also possesses anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective and reno-protective effects [1] [2] [3] [8]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NK-104 hemicalcium; Pitavastatin hemicalcium. CAS No. 147526-32-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B0144. | |
| Purpactin A | Purpactin A is a cholesterol acyltransferase (ACAT) inhibitor produced by Pen. purpurogenum FO-6. Synonyms: 1'-O-acetylpenicillide; Vermixocin B. Molecular formula: C23H26O7. Mole weight: 414.45. | |
| Pyripyropene A ((+)-Pyripyropene A, PPPA, FO 1289A) | Antibiotic. Highly specific inhibitor of acyl-coenzyme A:cholesterol acetyltransferase 2 (ACAT2). Anti-angiogenic. Antiatherogenic and antiatherosclerotic agent. Shows cholesterol-lowering and atheroprotective activities. Group: Biochemicals. Alternative Names: (+)-Pyripyropene A, PPPA, FO 1289A. Grades: Highly Purified. CAS No. 147444-03-9. Pack Sizes: 250ug, 1mg. Molecular Formula: C31H37NO10, Molecular Weight: 583.6. US Biological Life Sciences. | Worldwide |
| Pyripyropene B | Pyripyropene B is a powerful acyl-CoA: cholesterol acyltransferase 2 (ACAT2) inhibitor produced by the fungus Aspergillus fumigatus FO 1289. It inhibits acyl-CoA: cholesterol acyltransferase with an IC50 of 117 nmol/L. Synonyms: 2H,11H-Naphtho[2,1-b]pyrano[3,4-e]pyran-11-one,3,6-bis(acetyloxy)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-12-hydroxy-4,6a,12b-trimethyl-4-[(1-oxopropoxy)methyl]-9-(3-pyridinyl)-,(3S,4R,4aR,6S,6aS,12R,12aS,12bS)-. CAS No. 151519-44-7. Molecular formula: C32H39NO10. Mole weight: 597.65. | |
| RVX-208 | RVX-208 is a potent inhibitor of BET bromodomains. RVX-208 functions by removing atherosclerotic plaque via reverse cholesterol transport (RCT). RVX-208 increases the production of ApoA-I in hepatocytes in vitro, and in vivo in monkeys and humans, which results in increased HDL-C, but the molecular target was not previously reported. Using binding assays and X-ray crystallography, we now show that RVX-208 selectively binds to bromodomains of the BET (Bromodomain and Extra Terminal) family, competing for a site bound by the endogenous ligand, acetylated lysine, and that this accounts for its pharmacological activity. siRNA experiments further suggest that induction of ApoA-I mRNA is mediated by BET family member BRD4. These data indicate that RVX-208 increases ApoA-I production through an epigenetic mechanism and suggests that BET inhibition may be a promising new approach to the treatment of atherosclerosis. Synonyms: RVX208; RVX 208; RVX-208; Apabetalone. Grades: >98%. CAS No. 1044870-39-4. Molecular formula: C20H22N2O5. Mole weight: 370.40. | |
| Sbc-1107326 | SBC-110736 is an inhibitor of proprotein convertase subtilisin kexin type 9 (PCSK9). Study shows that it can lower cholesterol levels in mice. Synonyms: Sbc 1107326; Sbc1107326; N-[4-(2-Phenyl-4-p-tolyl-piperazine-1-carbonyl)-phenyl]-acetamide. Grades: ≥98%. CAS No. 1629166-02-4. Molecular formula: C26H27N3O2. Mole weight: 413.51. | |
| SPT Imidazopyridine 1 | SPT Imidazopyridine 1 is a potent serine palmitoyl transferase (SPT) inhibitor (IC50 = 5 nM) used for the treatment of type 2 diabetes and dyslipidemia. SPT Imidazopyridine 1 inhibits incorporation of 14C-serine into ceramide in dose manner, and lowers plasma ceramide levels in vivo. It also has the effect of increasing plasma HDL and reducing VLDL cholesterol levels in rats. Synonyms: SPT-IN-1; SPT IN 1; SPT Inhibitor 1; Imidazopyridine 1; 4-[6-(1-Oxoheptyl)imidazo[1,2-a]pyridin-8-yl]benzeneacetic acid; 2-[4-(6-heptanoylimidazo[1,2-a]pyridin-8-yl)phenyl]acetic acid; SPT-IN-1. Grades: ≥98%. CAS No. 1933533-18-6. Molecular formula: C22H24N2O3. Mole weight: 364.44. | |
| Xylitol | Xylitol can be classified as a polyol and sugar alcohol, exhibiting inhibitory activity on cancer cell proliferation. It induces autophagy ( Autophagy ) and cell death in A549 cells by activating the autophagy signaling pathway, as evidenced by the increased expression of LC3-II and Atg5-Atg12 upon Xylitol treatment. Additionally, Xylitol inhibits acetaldehyde production by Candida species, thereby reducing their carcinogenic potential. In vivo, Xylitol induces alterations in the gut microbiota of mice, which may enhance cholesterol accumulation and upregulate hepatic ChREBP, while also slowing tumor growth in the B16F10 melanoma C57BL/6 mouse model [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: Xylite. CAS No. 87-99-0. Pack Sizes: 10 mM * 1 mL; 1 g. Product ID: HY-N0538. | |
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