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| Product | Description | |
|---|---|---|
| Chymotrypsin | Chymotrypsin (Chymotrypsin A) is a serine protease produced by the pancreas. Chymotrypsin cleaves protein chains at the carboxyl side of aromatic amino acids [1] [2]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: EC 3.4.21.1; Chymotrypsin A. CAS No. 9004-7-3. Pack Sizes: 500 mg; 1 g. Product ID: HY-108910. |  |
| Chymotrypsin | Chymotrypsin is a proteolytic enzyme. It can priority hydrolyze tyrosine containing l-isomer, phenylalanine and the peptide bond of tryptophan, the best effective condition is pH 8.0. Its activity can be restrained by heavy metal or natural trypsin inhibitor in some degrees. Applications: Practically used to heal cicatrisation caused by injuries, inflammation and it is also used for avoiding part dropsy, blood-gathering, haematoma caused by wrick, breast dropsy after operation, tympanitis and rhinitis brief introduction of production: the high purity chymotrypsin is extracted from bovine or porcine pancreas and purified by affinity chromatography in order to avoid being polluted by other protease. Group: Enzymes. Synonyms: Chymotrypsin; Alpha-chymotrypsin; Chymotrypsin A; Chymotrypsin B. CAS No. 9004-7-3. Chymotrypsin. Appearance: inquire. Chymotrypsin; Alpha-chymotrypsin; Chymotrypsin A; Chymotrypsin B. Pack: inquire. Cat No: BIO-1012. |  |
| Chymotrypsin 1000usp-E/m | Chymotrypsin 1000usp-E/m. |  CA, FL & NJ |
| chymotrypsin C | Formed from pig chymotrypsinogen C, and from cattle subunit II of procarboxypeptidase A. Reacts more readily with Tos-Leu-CH2Cl than Tos-Phe-CH2Cl in contrast to chymotrypsin. In peptidase family S1 (trypsin family). Group: Enzymes. Enzyme Commission Number: EC 3.4.21.2. CAS No. 9036-9-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4119; chymotrypsin C; EC 3.4.21.2; 9036-09-3. Cat No: EXWM-4119. | |
| Chymotrypsin from Human, Recombinant | Chymotrypsin is a recombinant serine endopeptidase expressed in E.coli, purified with HPLC, the gene sequence is the same as human chymotrypsin. Recombinant chymotrypsin hydrolyzes at the carboxyl side of aromatic amino acids residues: Tyr, Phe and Trp. Cleavage may also be observed, but at a lower rate, at Leu and Met. Chymotrypsin activity is optimal in pH 7.0-9.0. Applications: Hydrolysis of proteins by chymotrypsin alone or in combination with other proteases. suitable for peptide mapping, fingerprinting, and sequence analysis. Group: Enzymes. Synonyms: EC 3.4.21.1; chymotrypsins A and B; alpha-chymar ophth; avazyme; chymar; chymotest; enzeon; quimar; quimotrase; alpha-chymar; alpha-chymotrypsin A; alpha-chymotrypsin; Chymotrypsin; &alpha. Enzyme Commission Number: EC 3.4.21.1. CAS No. 9004-7-3. Purity: > 95% by HPLC. Chymotrypsin. Mole weight: 26,950 Da. Activity: >1000 unit/mg protein. Storage: Recombinant Chymotrypsin lyophilized should be stored under 2°C-8°C in sealed container. It is stable within 24 months. After dissolved, it should be stored under -20°C. Form: White lyophilized. Source: E. coli. Species: Human. EC 3.4.21.1; chymotrypsins A and B; alpha-chymar ophth; avazyme; chymar; chymotest; enzeon; quimar; quimotrase; alpha-chymar; alpha-chymotrypsin A; alpha-chymotrypsin; Chymotrypsin; α-Chymotrypsin. Cat No: NATE-1890. | |
| Chymotrypsin-polyethylene glycol | Enzyme PEG conjugate was made from by the covalent attachment of PEG 5000 to the enzyme molecule via its amino grops. Conjugate is provided in lyophilized powder form. Group: Enzymes. Synonyms: Chymotrypsin PEG Conjugate; Chymotrypsin-PEG; PEG-Chymotrypsin; Chymotrypsin-polyethylene glycol. Chymotrypsin. Storage: Store at -20°C. Form: Lyophilized powder. Chymotrypsin PEG Conjugate; Chymotrypsin-PEG; PEG-Chymotrypsin; Chymotrypsin; PEG; Chymotrypsin-polyethylene glycol. Cat No: NATE-1581. | |
| Chymotrypsin Substrate I, Colorimetric | Chymotrypsin Substrate I, Colorimetric is a substrate for the assay of chymotrypsin activity and for S. griseus protease B. Contains 90 mg D-mannitol and 10 mg substrate. Group: Biochemicals. Grades: Highly Purified. CAS No. 68982-90-1. Pack Sizes: 10mg, 25mg. Molecular Formula: C23H25N5O8, Molecular Weight: 499.47. US Biological Life Sciences. |  Worldwide |
| a-Chymotrypsin | a-Chymotrypsin. Group: Biochemicals. Grades: Highly Purified. CAS No. 9004-7-3. Pack Sizes: 2g, 5g, 10g, 25g, 50g. US Biological Life Sciences. | Worldwide |
| alpha-Chymotrypsin from bovine pancreas | alpha-Chymotrypsin from bovine pancreas. Group: Biochemicals. Alternative Names: TLCK-Chymotrypsin. Grades: Highly Purified. CAS No. 9004-3-7. Pack Sizes: 500mg, 1g, 2g, 5g. US Biological Life Sciences. | Worldwide |
| Immobilized bovine chymotrypsin | Immobilized bovine chymotrypsin is ideal for digestions of proteins and peptides. Chymotrypsin is a protease that cleaves peptide bonds at Trp, Tyr, Phe, Leu and Met. Chymotrypsin protease is generally specific for hydrophobic residues and is often used to provide complementary sequence coverage when compared to tryptic digested samples. Group: Enzymes. Synonyms: EC 3. 4. 21. 1; α-Chymotrypsin; chymotrypsins A and B; alpha-chymar ophth; avazyme; chymar; chymotest; enzeon; quimar; quimotrase; alpha-chymar; alpha-chymotrypsin A; alpha-chymotrypsin; Chymotrypsin. Enzyme Commission Number: EC 3. 4. 21. 1. Purity: >95% by SDS-PAGE analysis. Mole weight: 25000. Stability: 12 months from delivery. Storage: 4°C. Form: Resin. Source: Bovine pancreas. Species: Bovine. EC 3. 4. 21. 1; α-Chymotrypsin; chymotrypsins A and B; alpha-chymar ophth; avazyme; chymar; chymotest; enzeon; quimar; quimotrase; alpha-chymar; alpha-chymotrypsin A; alpha-chymotrypsin; Chymotrypsin; Immobilized chymotrypsin. Cat No: NATE-1754. | |
| Immobilized TLCK-Chymotrypsin on F7m | α-chymotrypsin hydrolyzes peptides, amides, and esters preferentially at the carboxyl groups of hydrophobic amino acids (L-tyrosine, L-phenylalanine, and L-tryptophan but also bonds of leucyl, methionyl, asparaginyl, and glutamyl residues). F7m: 1. 0 mg α-chymotrypsin per CR-column immobilized on polyvinyl. 55 units immobilized per CR-columnNr. 5 Storage buffer: 50 mM Tris/HCl, pH 7. 5Nr. 5 Reaction buffer: 50 mM Tris/HCl, pH 7. 5; also active in 0.1% SDSNr. 6 Washing buffer: 50 mM Tris/HCl, 1 M NaCl, pH 7. 5. Group: Enzymes. Synonyms: EC 3. 4. 21. 1; α-Chymotrypsin; chymotrypsins A and B; alpha-chymar ophth; avazyme; chymar; chymotest; enzeon; quimar; quimotrase; alpha-chymar; alpha-chymotrypsin A; alpha-chymotrypsin; Chymotrypsin. Enzyme Commission Number: EC 3. 4. 21. 1. Storage: 4 °C. Source: Bovine pancreas. EC 3. 4. 21. 1; α-Chymotrypsin; chymotrypsins A and B; alpha-chymar ophth; avazyme; chymar; chymotest; enzeon; quimar; quimotrase; alpha-chymar; alpha-chymotrypsin A; alpha-chymotrypsin; Chymotrypsin; Immobilized TLCK-Chymotrypsin; Immobilized Chymotrypsin; TLCK-Chymotrypsin. Cat No: NATE-1769. | |
| Immobilized TLCK-Chymotrypsin on G3m | α-chymotrypsin hydrolyzes peptides, amides, and esters preferentially at the carboxyl groups of hydrophobic amino acids (L-tyrosine, L-phenylalanine, and L-tryptophan but also bonds of leucyl, methionyl, asparaginyl, and glutamyl residues). G3m: 25 ug α-chymotrypsin per CR-column immobilized on dextran. 1. 4 units immobilized per CR-column. This CR-column cuts at least 100 ug tubulin per application; it cuts 5 ug/minuteBSA without SDS, but at least 45 ug/minute BSA in the presence of 0.1% SDS. Nr. 5 Storage buffer: 50 mM Tris/HCl, pH 7. 5Nr. 5 Reaction buffer: 50 mM Tris/HCl, pH 7. 5; also active in 0.1% SDSNr. 6 Washing buffer: 50 mM Tris/HCl, 1 M NaCl, pH 7. 5. Group: Enzymes. Synonyms: EC 3. 4. 21. 1; α-Chymotrypsin; chymotrypsins A and B; alpha-chymar ophth; avazyme; chymar; chymotest; enzeon; quimar; quimotrase; alpha-chymar; alpha-chymotrypsin A; alpha-chymotrypsin; Chymotrypsin. Enzyme Commission Number: EC 3. 4. 21. 1. Storage: 4 °C. Source: Bovine pancreas. EC 3. 4. 21. 1; α-Chymotrypsin; chymotrypsins A and B; alpha-chymar ophth; avazyme; chymar; chymotest; enzeon; quimar; quimotrase; alpha-chymar; alpha-chymotrypsin A; alpha-chymotrypsin; Chymotrypsin; Immobilized TLCK-Chymotrypsin; Immobilized Chymotrypsin; TLCK-Chymotrypsin. Cat No: NATE-1770. | |
| Native Bovine α-Chymotrypsin | Chymotrypsin is a digestive enzyme component of pancreatic juice acting in the duodenum where it performs proteolysis, the breakdown of proteins and polypeptides. Chymotrypsin preferentially cleaves peptide amide bonds where the carboxyl side of the amide bond (the P1 position) is a large hydrophobic amino acid (tyrosine, tryptophan, and phenylalanine). These amino acids contain an aromatic ring in their sidechain that fits into a 'hydrophobic pocket' (the S1 position) of the enzyme. It is activated in the presence of trypsin. Applications: Chymotrypsin (ec 3.4.21.1, chymotrypsins a and b, alpha-chymar ophth, avazyme, chymar, chymotest, enzeon, quimar, quimotrase, alpha-chym...ate p1 sidechain and the enzyme s1 binding cavity accounts for the substrate specificity of this enzyme. chymotrypsin also hydrolyzes other amide bonds in peptides at slower rates, particularly those containing leucine and methionine at the p1 position. structurally, it is the archetypal structure for its superfamily, the pa clan of proteases. Group: Enzymes. Synonyms: EC 3.4.21.1; α-Chymotrypsin; chymotrypsins A and B; alpha-chymar ophth; avazyme; chymar; chymotest; enzeon; quimar; quimotrase; alpha-chymar; alpha-chymotrypsin A; alpha-chymotrypsin; Chymotrypsin. Enzyme Commission Number: EC 3.4.21.1. CAS No. 9004-7-3. Chymotrypsin. Activity: > 40 units/mg protein. Sto | |
| Native Bovine α-Chymotrypsinogen A | Chymotrypsinogen is a proteolytic enzyme and a precursor (zymogen) of the digestive enzyme chymotrypsin. It is a single polypetide chain consisting of 245 amino acid residues. It is synthesized in the acinar cells of the pancreas and stored inside membrane-bounded granules at the apex of the acinar cell. The cell is then stimulated by either a hormonal signal or a nerve impulse and the contents of the granules spill into a duct leading into the duodenum. Applications: The enzyme has been used in the non-invasive determination of solid-state protein conformation using near infrared (nir) spectroscopy. it has been used to study the partitioning of protein in polymer/polymer aqueous two-phase systems. the enzyme has also been used for self-interaction chromatography applications, to test the rapid measurement of protein osmotic second virial coefficients. in this technique, the protein is immobilized on chromatographic particles and its retention is measured using isocratic elution. Group: Zymogens. Synonyms: 9035-75-0; Chymotrypsinogen; α-Chymotrypsino. CAS No. 9035-75-0. Chymotrypsinogen A. Activity: > 40 units/mg solid. Storage: -20°C. Form: essentially salt-free, lyophilized powder. Source: Bovine Pancreas. Species: Bovine. 9035-75-0; Chymotrypsinogen; α-Chymotrypsinogen A; Chymotrypsinogen A; Chymotrypsin. Cat No: NATE-0748. | |
| Native Bovine Chymotrypsinogen A | Chymotrypsinogen is a proteolytic enzyme and a precursor (zymogen) of the digestive enzyme chymotrypsin. It is a single polypetide chain consisting of 245 amino acid residues. It is synthesized in the acinar cells of the pancreas and stored inside membrane-bounded granules at the apex of the acinar cell. The cell is then stimulated by either a hormonal signal or a nerve impulse and the contents of the granules spill into a duct leading into the duodenum. Group: Zymogens. Synonyms: chymotrypsinogen A; Chymotrypsinogen; Chymotrypsin. CAS No. 9035-75-0. Purity: Purified, Five times crystallized, electrophoretically homogeneous. Chymotrypsinogen A. Activity: Activates to at least 45 units per mg protein. Stability: The enzyme is stable for days in solution at pH 3.0 and for years as a dry powder when stored refrigerated. Storage: Store at 2-8°C. Form: lyophilized powder. Source: Bovine Pancreas. Species: Bovine. chymotrypsinogen A; Chymotrypsinogen; Chymotrypsin. Cat No: NATE-0134. | |
| Native Bovine Trypsin & Chymotrypsin Mixtures | Native Bovine Trypsin & Chymotrypsin Mixtures. Creative enzymes is a world leading producer of trypsin / chymotrypsin mixtures. trypsin and chymotrypsin are extracted from bovine pancreas and pancreatic juices using multiple precipitation, fractionation, and filtration steps. creative enzymes products are not intended for use in pharmaceutical applications. Applications: In combination with chymotrypsinogen and ribonuclease it is used to formulate anti-inflammatory tablets /treatment of wounds (internal and external) / mixtures of trypsin and chymotrypsin in different ratios frequently are used in digestive aids and food. Group: Enzymes. Synonyms: Trypsin & Chymotrypsin. Trypsin-Chymotrypsin. Activity: >1000 :1000 NF U/mg. Storage: Store at <-15°C. Source: Bovine pancreas. Species: Bovine. Trypsin & Chymotrypsin. Cat No: NATE-0719. | |
| Native Human α-Chymotrypsin | Chymotrypsin is a digestive enzyme component of pancreatic juice acting in the duodenum where it performs proteolysis, the breakdown of proteins and polypeptides. Chymotrypsin preferentially cleaves peptide amide bonds where the carboxyl side of the amide bond (the P1 position) is a large hydrophobic amino acid (tyrosine, tryptophan, and phenylalanine). These amino acids contain an aromatic ring in their sidechain that fits into a 'hydrophobic pocket' (the S1 position) of the enzyme. It is activated in the presence of trypsin. Applications: Human α-chymotrypsin has been used in a study to assess the quantitative structure-activity relationships for organophosphates binding to trypsin and chymotrypsin. human α-chymotrypsin has also been used in a study to investigate the direct detection of native proteins in biological matrices using extractive electrospray ionization mass spectrometry. Group: Enzymes. Synonyms: EC 3.4.21.1; α-Chy. Enzyme Commission Number: EC 3.4.21.1. CAS No. 9004-7-3. Chymotrypsin. Mole weight: mol wt 25 kDa. Storage: -20°C. Form: lyophilized powder. Source: Human pancreas. Species: Human. EC 3.4.21.1; α-Chymotrypsin; chymotrypsins A and B; alpha-chymar ophth; avazyme; chymar; chymotest; enzeon; quimar; quimotrase; alpha-chymar; alpha-chymotrypsin A; alpha-chymotrypsin; Chymotrypsin. Cat No: NATE-0747. | |
| Native Swine (Bovine) Trypsin-Chymotrypsin 1: 1 | Trypsin-Chymotrypsin is the co-crystal of Chymotrypsin and Trypsin so it has the properties of both. The activity of hydrolyzing casein is as much as Chymotrypsin. But the activity of its Chemotrypsin to hydrolyze N-Benzoyl-L-tyrosine ethyl ester?BTEE?is three times higher than Chemotrypsin.The activity of hydrolyze ester bond similar to that of Trypsin. It is stable when dry and easy to be inactivated in solutions. The optimum pH is 7.0-8.0. The high purity Trypsin-Chymotrypsin is purified by re-crystallization, and then by Ion Exchange Chromatography and ultra-filtration. Applications: 1. as pharmaceutical raw materials for antibacterial, anti-inflammatory, clinical. 2. as analytical reagents used in scientific research institutions. Group: Enzymes. Synonyms: Trypsin-Chymotrypsin 1: 1. Trypsin-Chymotrypsin. Activity: Trypsin: 1000 ~1100 USP units/mg, powder; Chymotrypsin 1000 ~1100 USPunits/mg, powder. Appearance: White or almost white powder. Storage: Sealed, Dark, at temperature 2-8°C. Form: Powder. Source: Swine (Bovine) pancreas. Species: Swine (Bovine). Trypsin-Chymotrypsin 1: 1. Cat No: PHAM-378. | |
| Native Swine (Bovine) Trypsin-Chymotrypsin 1: 250 | Trypsin-Chymotrypsin is the co-crystal of Chymotrypsin and Trypsin so it has the properties of both. The activity of hydrolyzing casein is as much as Chymotrypsin. But the activity of its Chemotrypsin to hydrolyze N-Benzoyl-L-tyrosine ethyl ester?BTEE?is three times higher than Chemotrypsin.The activity of hydrolyze ester bond similar to that of Trypsin. It is stable when dry and easy to be inactivated in solutions. The optimum pH is 7.0-8.0. The high purity Trypsin-Chymotrypsin is purified by re-crystallization, and then by Ion Exchange Chromatography and ultra-filtration. Applications: 1. as a laboratory analysis reagent, is scientific research institutions widely used. 2. animal cell culture of tissue processing. Group: Enzymes. Synonyms: Trypsin-Chymotrypsin 1: 250. Trypsin-Chymotrypsin. Activity: Trypsin > 2400 USP units/mg, powder; Chymotrypsin < 75 USP units/mg, powder. Appearance: White or almost white powder. Storage: Sealed, Dark, at temperature 2-8°C. Form: Powder. Source: Swine (Bovine) pancreas. Species: Swine (Bovine). Trypsin-Chymotrypsin 1: 250. Cat No: PHAM-379. | |
| Native Swine (Bovine) Trypsin-Chymotrypsin 6: 1 | Trypsin-Chymotrypsin is the co-crystal of Chymotrypsin and Trypsin so it has the properties of both. The activity of hydrolyzing casein is as much as Chymotrypsin. But the activity of its Chemotrypsin to hydrolyze N-Benzoyl-L-tyrosine ethyl ester?BTEE?is three times higher than Chemotrypsin.The activity of hydrolyze ester bond similar to that of Trypsin. It is stable when dry and easy to be inactivated in solutions. The optimum pH is 7.0-8.0. The high purity Trypsin-Chymotrypsin is purified by re-crystallization, and then by Ion Exchange Chromatography and ultra-filtration. Applications: 1. in the clinical, the treatment of various inflammatory, inflammatory edema, hematoma, postoperative adhesion, ulcer, thrombus and so on and have a certain effect to chronic bronchitis asthma, gastritis, cervicitis, pelvic inflammatory disease, suppurative otitis media, prostatitis, thrombophlebitis and cerebral thrombosis. 2. application in modern industrial fields, such as senior leather depilation, softener. Group: Enzymes. Synonyms: . Trypsin-Chymotrypsin. Activity: Trypsin > 2400 USP units/mg, powder; Chymotrypsin > 400 USP units/mg, powder. Appearance: White or almost white powder. Storage: Sealed, Dark, at temperature 2-8°C. Form: Powder. Source: Swine (Bovine) pancreas. Species: Swine (Bovine). Trypsin-Chymotrypsin 6: 1. Cat No: PHAM-380. | |
| Sequencing Grade Chymotrypsin from Human, Recombinant | Chymotrypsin is a recombinant serine endopeptidase expressed in E.coli, purified with HPLC, the gene sequence is the same as human chymotrypsin. Recombinant chymotrypsin hydrolyzes at the carboxyl side of aromatic amino acids residues: Tyr, Phe and Trp. Cleavage may also be observed, but at a lower rate, at Leu and Met. Chymotrypsin activity is optimal in pH 7.0-9.0.The sequencing grade human chymotrypsin can be used alone or in combination with other proteases to produce protein digests for peptide mapping applications or protein identification by peptide mass fingerprinting or MS/MS spectral matching. It is suitable for digestion reactions in-solution or in-gel. ...1. CAS No. 9004-7-3. Purity: > 98% by HPLC. Chymotrypsin. Mole weight: 26,950 Da. Activity: >1500 unit/mg protein. Storage: Recombinant Chymotrypsin lyophilized should be stored under 2°C-8°C in sealed container. It is stable within 24 months. After dissolved, it should be stored under -20°C. It is stable within 24 months and above 90% activity remained after 3 times repeated freezing and thawing. Form: Lyophilized. Source: E. coli. Species: Human. EC 3.4.21.1; chymotrypsins A and B; alpha-chymar ophth; avazyme; chymar; chymotest; enzeon; quimar; quimotrase; alpha-chymar; alpha-chymotrypsin A; alpha-chymotrypsin; Chymotrypsin; α-Chymotrypsin; Sequencing Grade | |
| TLCK-treated Chymotrypsin | TLCK-treated Chymotrypsin is a serine protease. Chymotrypsin cleaves protein chains at the carboxyl side of aromatic amino acids. TLCK treated to inactivate residual tryspin activity [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 9004-7-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108910B. | |
| 1-Methyl-1H-benzotriazole | A benzotriazole derivative with potential inhibitory effect on protease enzymes chymotrypsin, trypsin and papain. Group: Biochemicals. Grades: Highly Purified. CAS No. 13351-73-0. Pack Sizes: 1g, 2.5g. Molecular Formula: C7H7N3. US Biological Life Sciences. | Worldwide |
| 1-Methyl-1H-benzotriazole-d3 | 1-Methyl-1H-benzotriazole-d3 is the labeled derivative of 1-Methyl-1H-benzotriazole (M289810), which is the benzotriazole derivative with potential inhibitory effect on protease enzymes chymotrypsin, trypsin and papain. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1g, 10g. Molecular Formula: C7H4D3N3, Molecular Weight: 136.169999999999. US Biological Life Sciences. | Worldwide |
| 2,4-Difluorobenzoic Acid-d3 | 2,4-Difluorobenzoic Acid-d3, is the labeled analogue of 2,4-Difluorobenzoic Acid (D445710). 2,4-Difluorobenzoic Acid-d3, can be used for the synthesis of N2-Acetyl-N-(4-fluorobenzyl)carbazyl-α-chymotrypsin, which resembles the acylated enzyme intermediate formed during reaction of Chymotrypsine with substrate derived from phenylalanine. Group: Biochemicals. Grades: Highly Purified. CAS No. 1219804-63-3. Pack Sizes: 50mg, 500mg. Molecular Formula: C7HD3F2O2, Molecular Weight: 161.12. US Biological Life Sciences. | Worldwide |
| 3,3'-Diamino-4'-methoxyflavone, DD1 (3-amino-2-(3-amino-4-methoxyphenyl)-4H-chromen-4-one, p76S6 Inhibitor, DD1, Proteasome Inhibitor, DD1) | A cell-permeable flavone derivative that arrests the proliferation of acute myeloid leukemia cells (NB4, U937, HL-60, OCI AML3), in a dose and time-dependent manner (optimum at ~20uM and 96h) and blocks the colony formation in samples from acute myeloid leukemia patients, without affecting normal blood cells. Shown to reduce mitochondrial membrane potential and Bad phosphorylation (at Ser136), induce Bax and caspase 3, 8, and 9 activation in U937 cells. Does not affect the phosphorylation of Akt1, but significantly reduces the expression and phosphorylation of p70S6 kinase in U937 cells. Reported to inhibit the chymotrypsin-like activity of proteasome (IC50 = 2.0uM) and this effect is synergistic with bortezomib. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 6-Aminohexanoic acid (EACA) | 6-Aminohexanoic Acid is a reagent commonly used for the extraction of aldehydes from reaction mixtures. 6-Aminohexanoic Acid has also been shown to improve solubilization of membrane proteins in electrophoresis. Studies suggest that 6-Aminohexanoic Acid inhibits the activation of the first component of the complement system.EACA is reported to inhibit chymotrypsin, Factor VIIa, lysine carboxypeptidase, plasmin, and plasminogen activator. Lysine analog. Promotes rapid dissociation of plasmin, thereby inhibiting the activation of plasminogen and subsequent fibrinolysis. Reported to inhibit plasminogen binding to activated platelets. An early report indicated that it inhibits the activation of the first component of the complement system. Binds and inactivates Carboxypeptidase B. Group: Biochemicals. Alternative Names: 6-Amino-n-hexanoic Acid; 6-Aminocaproic Acid; 6-Aminohexanoic Acid; A 14719; ACS; Acepramin; Acepramine; Acikaprin; Afibrin; Amicar; Amikar; Aminokapron; CL 10304; CY 116; Caplamin; Capramol; Caprocid; Caprolisin; EACA; EACS; Epsamon; Epsicapron; Epsikapron; Epsilcapramin; Epsilon S; Hemocaprol; Hemopar; Hepin; Ipsilon; NSC 212532; NSC 26154; NSC 400230; Respramin; ε-Amino-n-caproic. Grades: Highly Purified. CAS No. 60-32-2. Pack Sizes: 500g, 1Kg. Molecular Formula: C6H13NO2, Molecular Weight: 131.17. US Biological Life Sciences. | Worldwide |
| 6-N-Biotinylaminohexyl Isopropyl Phosphorofluoridate, Hemihydrate | A potent tool for the inhibition and isolation of Serine Esterases and Proteases. Also a potent inhibitor of a-chymotrypsin. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| 7-(N-Benzyloxycarbonylglycyl-glycyl-leucyl)amino-4-methylcoumarin | 7-(N-Benzyloxycarbonylglycyl-glycyl-leucyl)amino-4-methylcoumarin is a fluorogenic substrate for the chymotrypsin-like activity of the 20S proteasome. Synonyms: 7-Z-Gly-gly-leu-ME; L-Leucinamide, N-[ (phenylmethoxy)carbonyl]glycylglycyl-N- (4-methyl-2-oxo-2H-1-benzopyran-7-yl)-; Z-GGL-AMC. Grades: ≥98%. CAS No. 97792-39-7. Molecular formula: C28H32N4O7. Mole weight: 536.58. |  |
| Ac-ANW-AMC | Ac-ANW-AMC is a 7-amino-4-methylcoumarin labelled fluorogenic peptidyl substrate and used for measuring chymotrypsin-like activity of the immunoproteasome. Synonyms: (S)-N1-((S)-3-(1H-indol-3-yl)-1-((4-methyl-2-oxo-2H-chromen-7-yl)amino)-1-oxopropan-2-yl)-2-((S)-2-acetamidopropanamido)succinamide; N-Acetyl-L-alanyl-L-asparaginyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)-L-tryptophanamide; Acetyl-Ala-Asn-Trp-7-amido-4-methylcoumarin. Grades: >99%. Molecular formula: C30H32N6O7. Mole weight: 588.61. | |
| Acetyl-3-(2-naphthyl)-D-alanine | Acetyl-3-(2-naphthyl)-D-alanine was used to study the aromatic binding site of α-chymotrypsin. It was used to design an asymmetric synthesis of a new cylindrically chiral and air-stable ferrocenyldiphosphine and its application to rhodium-catalyzed asymmetric hydrogenation. Synonyms: Ac-D-Ala(2-naphthyl)-OH; (R)-N-Acetyl-2-naphthylalanine; Ac-D-2-Nal-OH; (R)-2-ACETAMIDO-3-(NAPHTHALEN-2-YL)PROPANOIC ACID; N-Acetyl-3-(2-naphthyl)-D-alanine; 2-Naphthalenepropanoic acid, a-(acetylamino)-, (aR)-; Ac-D-Ala(2-Naph)-OH. Grades: ≥ 98% (HPLC). CAS No. 37440-01-0. Molecular formula: C15H15NO3. Mole weight: 257.28. | |
| Acetyl-L-phenylalanine methyl ester | A substrate for chymotrypsin. Synonyms: Ac-L-Phe-Ome; Methyl N-acetyl-L-phenylalaninate. Grades: ≥ 99% (HPLC). CAS No. 3618-96-0. Molecular formula: C12H15NO3. Mole weight: 221.30. | |
| Acetyl-L-tyrosine ethyl ester hydrate | A substrate for chymotrypsin and carboxypeptidase Y. Synonyms: Ac-L-Tyr-OEt H2O; Ethyl N-acetyl-L-tyrosinate hydrate. Grades: ≥ 99.0% (HPLC). CAS No. 36546-50-6. Molecular formula: C13H17NO4·H2O. Mole weight: 269.30. | |
| Ac-Nle-Pro-Nle-Asp-AMC | Ac-Nle-Pro-Nle-Asp-AMC is a substrate for proteasomes. It can be cleaved by the caspase-like site of proteasome, also known as postglutamyl peptide hydrolase (PGPH). AMC (7-amino-4-methylcoumarin) is released and produces the fluorescence utilized to quantify the caspase-like site activity. Ac-Nle-Pro-Nle-Asp-AMC also inhibits the chymotrypsin-like activity of the proteasome allosterically when bound to the caspase-like site. Synonyms: Ac-Nle-Pro-Nle-Asp-7-amido-4-Methylcoumarin; Ac-nLPnLD-AMC; N-acetyl-L-norleucyl-L-prolyl-L-norleucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-α-asparagine; L-α-Asparagine, N-acetyl-L-norleucyl-L-prolyl-L-norleucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-; (3S) -4-Hydroxy-3- ({ (2S) -1-hydroxy-2-[ (hydroxy{ (2S) -1-[N- (1-hydroxyethylidene) -L-norleucyl]-2-pyrrolidinyl}methylene) amino]hexylidene}amino) -4-[ (4-methyl-2-oxo-2H-chromen-7-yl) imino]butanoic acid. Grades: ≥98%. CAS No. 355140-49-7. Molecular formula: C33H45N5O9. Mole weight: 655.74. | |
| AEBSF HCl | AEBSF is a water-soluble, irreversible serine protease inhibitor that inhibits proteases like chymotrypsin, kallikrein, plasmin, thrombin, and trypsin. Synonyms: 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride; AEBSF hydrochloride; AEBSF. Grades: 98%. CAS No. 30827-99-7. Molecular formula: C8H11ClFNO2S. Mole weight: 239.69. | |
| AEBSF hydrochloride | AEBSF hydrochloride is an irreversible inhibitor of serine proteases , such as chymotrypsin, kallikrein, plasmin, thrombin, and trypsin. Uses: Scientific research. Group: Signaling pathways. CAS No. 30827-99-7. Pack Sizes: 10 mM * 1 mL; 100 mg; 200 mg. Product ID: HY-12821. | |
| Ala-Ala-Phe-pNA | Substrate for chymotrypsin and tripeptidyl peptidase I. Synonyms: Ala-Ala-Phe p-nitroanilide. Grades: ≥ 99% (Assay). CAS No. 61043-41-2. Molecular formula: C21H25N5O5. Mole weight: 427.46. | |
| α-Bromo-N-benzyl-N-methylacetamide | An α-bromo amides that inactivates α-chymotrypsin. Group: Biochemicals. Alternative Names: N-(Bromoacetyl)-N-methylbenzylamine; N-Methyl-N-benzyl-2-bromoacetamide; N-Methyl-N-benzylbromoacetamide. Grades: Highly Purified. CAS No. 73391-96-5. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| AM-114 | AM 114 is an inhibitor of chymotrypsin-like activity of the 20S proteasome. In addition, AM-114 shows anticancer activity, It can inhibit cell growth in human colon cancer HCT116 p53+/+ cells. Uses: Anticancer. Synonyms: AM-114; AM 114; AM114; Proteasome Inhibitor IX; ( (1Z, 1'Z)- (1-methyl-4-oxopiperidine-3, 5-diylidene)bis (methanylylidene))bis (4, 1-phenylene))diboronic acid. Grades: 98%. CAS No. 856849-35-9. Molecular formula: C20H21B2NO5. Mole weight: 377.01. | |
| Antifungal protein J | Antifungal protein J is an antimicrobial peptide found in Solanum tuberosum (Potato). It has antifungal activity and is an inhibitor of serine proteases chymotrypsin, pepsin and trypsin. Synonyms: AFP-J; Leu-Pro-Ser-Asp-Ala-Thr-Leu-Val-Leu-Asp-Gln-Thr-Gly-Lys-Glu-Leu-Asp-Ala-Arg-Leu. Grades: ≥96%. Molecular formula: C93H159N25O33. Mole weight: 2155.43. | |
| Aprotinin | Aprotinin is a bovine pancreatic trypsin inhibitor (BPTI) inhibitor which inhibits trypsin and chymotrypsin with K i s of 0.06 pM and 9 nM, respectively. Uses: Scientific research. Group: Peptides. CAS No. 9087-70-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P0017. | |
| Aprotinin, Bovine (Pancreatic trypsin inhibitor) | Aprotinin is a competitive serine protease inhibitor that inhibits trypsin, chymotrypsin, kallikrein and plasmin. Aprotinin forms stable complexes with and blocks the active sites of enzymes. Binding is reversible with most aprotinin-protease complexes, dissociating at pH >10 or <3. Effective concentration is equimolar with protease. Group: Biochemicals. Alternative Names: Antikrein; Antilysin; Antilysine; Aprostat; Aprotinin; BPTI; BPTI Trypsin Inhibitor; Basic Pancreatic Trypsin Inhibitor; Bayer A 128; Bovine Basic Pancreatic Trypsin Inhibitor; Bovine Pancreatic Trypsin Inhibitor; Bovine Trypsin Inhibitor; Fosten; Kallikrein-trypsin Inactivator; Kiker 52G; Kir Richter; Kunitz Pancreatic Trypsin Inhibitor; Kunitz Protease Inhibitor; Kunitz Trypsin Inhibitor; Kunitz-type Inhibitor; Kunitz-type Proteinase Inhibitor; Kunitz-type Trypsin Inhibitor; Onquinin; Pancreatic Basic Trypsin Inhibitor; Pancreatic Trypsin Inhibitor; Pancreatic Trypsin Inhibitor (Kunitz); Protease Inhibitor, Kunitz Type; RP 9921; Repulson; Trasuylol; Trasylol; Trazinin; Triazinin; Trypsin Inhibitor, Trasylol; Trypsin-kallikrein Inhibitor (Kunitz); Zymofren. Grades: Highly Purified. CAS No. 9087-70-1. Pack Sizes: 100mg, 250mg, 500mg, 1g. Molecular Formula: C???H???N??O??S?, Molecular Weight: 6511.45. US Biological Life Sciences. | Worldwide |
| Bentiromide | Bentiromide is a peptide that is broken down in the pancreas by chymotrypsin. The bentiromide test is an excellent means of confirming the diagnosis of pancreatic exocrine insufficiency by outpatient test of chymotrypsin function [1]. Uses: Scientific research. Group: Peptides. CAS No. 37106-97-1. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B1493. | |
| Benzoyl-L-tyrosine 4-nitroanilide | A substrate for the determination of chymotrypsin activity. Synonyms: Bz-L-Tyr-Pna; (S)-N-(3-(4-Hydroxyphenyl)-1-((4-nitrophenyl)amino)-1-oxopropan-2-yl)benzamide; N-Benzoyl-l-tyrosine p-nitroanilide. CAS No. 6154-45-6. Molecular formula: C22H19N3O5. Mole weight: 405.40. | |
| Boc-glycine 4-nitrophenyl ester | A substrate for chymotrypsin and trypsin. Synonyms: Boc-Gly-Onp; 4-nitrophenyl n-(tert-butoxycarbonyl)glycinate; 4-Nitrophenyl N-((1,1-dimethylethoxy)carbonyl)glycinate. Grades: ≥ 98% (TLC). CAS No. 3655-5-8. Molecular formula: C13H16N2O6. Mole weight: 296.30. | |
| Bromoenol lactone | BEL is a selective, potent, irreversible, mechanism-based inhibitor of myocardial cytosolic calcium-independent phospholipase A2 (iPLA2) with a Ki value of 180 nM. BEL induces the proteolysis of procaspase-9 and procaspase-3 and increases cleavage of poly (ADP-ribose) polymerase. BEL also inhibits macrophage iPLA2 in a concentration-dependent manner with an IC50 value of 60 nM and is an effective enzyme-activated irreversible inhibitor of chymotrypsin Ki of 636 nM. Long term treatment with BEL increased annexin-V binding to the cell surface and nuclear DNA damage. Synonyms: BEL; Haloenol lactone; HELSS. Grades: ≥95%. CAS No. 88070-98-8. Molecular formula: C16H13BrO2. Mole weight: 317.2. | |
| Carfilzomib | Carfilzomib is a tetrapeptide epoxyketone and an analog of epoxomicin, acting as a selective proteasome inhibitor, such as the chymotrypsin-like β5 subunit of the constitutive 20S proteasome (IC50 = 5.2 nM) and the β5i subunit of the immunoproteasome 20Si (LMP7; IC50 = 14 nM). It has been used as an injectable antineoplastic agent (IV only). Synonyms: Kyprolis; PR171; PR-171; PR 171; (2S)-4-methyl-N-[(2S)-1-[[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]-4-phenylbutanoyl]amino]pentanamide. Grades: ≥98%. CAS No. 868540-17-4. Molecular formula: C40H57N5O7. Mole weight: 719.9. | |
| Carfilzomib Impurity 13 hydrochloride | Carfilzomib is an anti-cancer drug acting as a selective proteasome inhibitor. Chemically, it is a tetrapeptide epoxyketone and an analog of epoxomicin. It is a second-generation and peptide epoxyketone class proteasome inhibitor that targets the chymotrypsin-like β5 subunit of the constitutive 20S proteasome with IC50 of 5.2 nM. Carfilzomib impurity 13 hydrochloride is a potential impurity found in commercial carfilzomib preparations. Grades: ≥95%. CAS No. 2319881-95-1. Molecular formula: C16H22N2O4·HCl. Mole weight: 342.8. | |
| cathepsin G | From azurophil granules of polymorphonuclear leukocytes. In peptidase family S1 (trypsin family). Group: Enzymes. Synonyms: chymotrypsin-like proteinase; neutral proteinase. Enzyme Commission Number: EC 3.4.21.20. CAS No. 56645-49-9. CTSG. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4120; cathepsin G; EC 3.4.21.20; 56645-49-9; chymotrypsin-like proteinase; neutral proteinase. Cat No: EXWM-4120. | |
| Cathepsin G Inhibitor I | Cathepsin G inhibitor I is a potent and selective inhibitor of cathepsin G with IC50 of 53 nM. It weakly inhibits chymotrypsin and poorly inhibits thrombin, factor Xa, factor IXa, plasmin, trypsin, tryptase, proteinase 3, and human leukocyte elastase. Synonyms: Cathepsin G Inhibitor I; 429676-93-7; Cathepsin G Inhibitor; CHEMBL164694; [2-[3-[(1-benzoylpiperidin-4-yl)-methylcarbamoyl]naphthalen-2-yl]-1-naphthalen-1-yl-2-oxoethyl]phosphonic acid; SCHEMBL1613660; DTXSID80431393; BDBM50139754; HY-103351; CS-0027703; A918760; (2-{3-[(1-Benzoyl-piperidin-4-yl)-methyl-carbamoyl]-naphthalen-2-yl}-1-naphthalen-1-yl-2-oxo-ethyl)-phosphonic acid; [2-[3-[(1-benzoylpiperidin-4-yl)-methylcarbamoyl]naphthalen-2-yl]-1-naphthalen-1-yl-2 oxoethyl]phosphonic acid. Grades: ≥95%. CAS No. 429676-93-7. Molecular formula: C36H33N2O6P. Mole weight: 620.6. | |
| Celastrol | Celastrol (Tripterine;Tripterin) is a proteasome inhibitor which potently and preferentially inhibits the chymotrypsin-like activity of a purified 20S proteasome with IC 50 of 2.5 μM. In addition, Celastrol is also an antibiotic with potent antimicrobial activity against standard and clinical methicillin-resistant Staphylococcus aureus (MRSA) strains, inducing oxidative stress and inhibiting DNA synthesis by binding to P5CDH [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: Tripterine; Tripterin. CAS No. 34157-83-0. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13067. | |
| CEP-7055 | CEP-18770 is An orally bioavailable synthetic P2 threonine boronic acid inhibitor of the chymotrypsin-like activity of the proteasome, with potential antineoplastic activity. Proteasome inhibitor CEP 18770 represses the proteasomal degradation of a variety of proteins, including inhibitory kappaBalpha (IkappaBalpha), resulting in the cytoplasmic sequestration of the transcription factor NF-kappaB; inhibition of NF-kappaB nuclear translocation and transcriptional up-regulation of a variety of cell growth-promoting factors; and apoptotic cell death in susceptible tumor cell populations. In vitro studies indicate that this agent exhibits a favorable cytotoxicity profile toward normal human epithelial cells, bone marrow progenitors, and bone marrow-derived stromal cells relative to the proteasome inhibitor bortezomib. The intracellular protein IkappaBalpha functions as a primary inhibitor of the proinflammatory transcription factor NF-kappaB. Synonyms: CEP 7055; CEP7055; 3-(9-isopropoxymethyl-5-oxo-6,7,12,13-tetrahydro-5H-indeno[2,1-a]pyrrolo[4,3-c]carbazol-12-yl)propyl 2-dimethylaminoacetate. CAS No. 402857-58-3. Molecular formula: C32H35N3O4. Mole weight: 525.65. | |
| CH 5450 | Z-Ile-Glu-Pro-Phe-Ome is a peptide inhibitor of human heart chymase which is a chymotrypsin-like enzyme that converts angiotensin I to angiotensin II. Synonyms: ZIEPF-Ome; N-benzyloxycarbonyl-L-isoleucyl-L-alpha-glutamyl-L-prolyl-L-phenylalanine methyl ester; Cbz-Ile-Glu-Pro-Phe-OMe; CH5450; CH-5450. Grades: ≥95%. CAS No. 252557-97-4. Molecular formula: C34H44N4O9. Mole weight: 652.73. | |
| Chymostatin | Chymostatin is a bioactive peptide that acts as a protease inhibitor with selectivity for chymotryptase-like serine proteases. It potently inhibits chymotrypsin and chymase, but it cannot block the activity of cathepsins, papain, and leukocyte elastase effectively. It doesn't have effect on trypsin, thrombin, plasmin, pepsin, and kallikrein. Uses: Serine proteinase inhibitors. Synonyms: [(S)-1-Carboxy-2-phenylethyl]-carbamoyl-a-[2-amidohexahydro-4(S)-pyrimidyl]-(S)-glycyl-[A= Leu B=Val C=Ile]-phenylalaninal (Mixture). Grades: ≥95% (a mixture of A, B, C). CAS No. 9076-44-2. Molecular formula: CxHyN7O6. Mole weight: 607.7. | |
| Chymostatin A | It is produced by the strain of Streptomyces hygroscopicus and Str.lavendulae. Chymostatin A can be used to inhibit chymotrypsin, papain and other serine/cysteine endopeptidase. Molecular formula: C31H41N7O6. Mole weight: 607.70. | |
| Clasto-Lactacystin beta-lactone (Omuralide) | In vitro lactacystin does not react with the proteasome. It rather undergoes a spontaneous conversion (lactonization) to the active metabolite clasto-lactacystin beta-lactone. Potent and selective irreversible and cell permeable proteasome inhibitor. Inhibits the chymotrypsin-like, trypsin-like and caspase-like peptidase activity of the proteasome. The active metabolite of lactacystin with higher potency since it does not require hydrolysis in order to become cell permeable. Calpain and cathepsin inhibitor. Apoptosis inducer. Anticancer compound. Induces differentiation and inhibits cell cycle progression in several tumor cell lines. Induces neuritogenesis. Autophagy inducer. Group: Biochemicals. Grades: Highly Purified. CAS No. 154226-60-5. Pack Sizes: 100ug. Molecular Formula: C10H15NO4, Molecular Weight: 213.2. US Biological Life Sciences. | Worldwide |
| coagulation factor IXa | A chymotrypsin homologue, and one of the γ-carboxyglutamic acid-containing blood coagulation factors. The proenzyme factor IX is activated by factor XIa. In peptidase family S1 (trypsin family). Group: Enzymes. Synonyms: activated Christmas factor; blood-coagulation factor IXa; activated blood-coagulation factor IX; autoprothrombin II; blood platelet cofactor II; activated blood coagulation factor XI. Enzyme Commission Number: EC 3.4.21.22. CAS No. 37316-87-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4122; coagulation factor IXa; EC 3.4.21.22; 37316-87-3; activated Christmas factor; blood-coagulation factor IXa; activated blood-coagulation factor IX; autoprothrombin II; blood platelet cofactor II; activated blood coagulation factor XI. Cat No: EXWM-4122. | |
| Delanzomib | Delanzomib, also known as CEP-18770, is An orally bioavailable synthetic P2 threonine boronic acid inhibitor of the chymotrypsin-like activity of the proteasome, with potential antineoplastic activity. Proteasome inhibitor CEP 18770 represses the proteasomal degradation of a variety of proteins, including inhibitory kappaBalpha (IkappaBalpha), resulting in the cytoplasmic sequestration of the transcription factor NF-kappaB; inhibition of NF-kappaB nuclear translocation and transcriptional up-regulation of a variety of cell growth-promoting factors; and apoptotic cell death in susceptible tumor cell populations. In vitro studies indicate that this agent exhibits a favorable cytotoxicity profile toward normal human epithelial cells, bone marrow progenitors, and bone marrow-derived stromal cells relative to the proteasome inhibitor bortezomib. The intracellular protein IkappaBalpha functions as a primary inhibitor of the proinflammatory transcription factor NF-kappaB. Uses: Proteasome inhibitors. Synonyms: CEP18770; CEP 18770; CEP-18770; Delanzomib. CAS No. 847499-27-8. Molecular formula: C21H28BN3O5. Mole weight: 413.27. | |
| Dihydroeponemycin | Dihydroeponemycin is a natural, irreversible inhibitor of proteasomal degradation of proteins that acts by binding the IFN-γ-inducible proteins LMP2 and LMP7, as well as the constitutive proteasome subunit X. It does not inhibit calpain or trypsin and has minor effects on cathepsin B and chymotrypsin at higher concentrations. It is cell-permeable and induces apoptosis in bovine aortic endothelial cells. Grades: ≥98%. CAS No. 126463-64-7. Molecular formula: C20H36N2O6. Mole weight: 400.5. | |
| Elasnin | Elasnin is isolated from certain strains of Streptomyces. Elasnin is a reversible inhibitor of elastase with IC50 values of 1.3 and 30 μg/ml for human granulocyte and pancreatic enzymes, respectively. It inhibits human leukocyte elastase, porcine pancreatic elastase, and chymotrypsin with Ki values of 93, 69 and 224 μM, respectively. Synonyms: 3,5-dibutyl-2-hydroxy-6-(6-oxoundecan-5-yl)-4H-pyran-4-one; 3,?5-Dibutyl-6-(1-butyl-2-oxoheptyl)?-4-hydroxy-2H-pyran-2-one. Grades: ≥98%. CAS No. 68112-21-0. Molecular formula: C24H40O4. Mole weight: 392.57. | |
| Elasnin (3,5-Dibutyl-4-hydroxy-6-(6-oxoundecan-5-yl)-2H-pyran-2-one) | Inhibitor of human leukocyte elastase (IC50=1.3ug/ml), different other elastases and chymotrypsin (IC50=82ug/ml). Group: Biochemicals. Grades: Highly Purified. CAS No. 68112-21-0. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| Epoxomicin | Antibiotic. Potent anticancer compound. Cell permeable, potent, selective and irreversible 20S proteasome inhibitor. Predominantly inhibits the chymotrypsin-like (CTRL) activity of the proteasome. Exhibits lower level inhibition of proteasome trypsin-like and caspase-like activitives (100 and 1,000-fold slower rates respectively). Anti-inflammatory. Antimicrobial and antimalarial. Anti-parasitic. Stimulates bone formation by inhibiting osteoblast proteasome activity. Induces Parkinson's-like symptoms in rats. The ubiquitin-proteasome system (UPS) and autophagy serve as two complementary, reciprocally regulated protein degradation systems. Blockade of UPS by Epoxomicin activates autophagy. Group: Biochemicals. Alternative Names: N-acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N- [ (1S) -3-methyl-1- [ [ (2R) -2-methyloxiranyl] carbonyl] butyl] -L-threoninamide, BU 4061T. Grades: Highly Purified. CAS No. 134381-21-8. Pack Sizes: 50ug, 100ug, 250ug, 500ug. Molecular Formula: C??H??N?O?, Molecular Weight: 554.7. US Biological Life Sciences. | Worldwide |
| Epoxomicin | Epoxomicin (BU-4061T) is an epoxyketone-containing natural product and a potent, selective and irreversible proteasome inhibitor. Epoxomicin covalently binds to the LMP7, X, MECL1, and Z catalytic subunits of the proteasome and potently inhibits primarily the chymotrypsin-like activity. Epoxomicin can cross the blood-brain barrier. Epoxomicin has strongly antitumor and anti-inflammatory activity [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. Alternative Names: BU-4061T. CAS No. 134381-21-8. Pack Sizes: 10 mM * 1 mL; 100 μg; 1 mg; 5 mg; 10 mg; 20 mg. Product ID: HY-13821. | |
| Epoxomicin (BU-4061T, N-acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N- [ (1S) -3-methyl-1 [ [ (2R) -2-methyloxiranyl] carbonyl] butyl] -L-threoninamide) | Originally isolated from Actinomycetes strain based on its potent in vivo antitumor activity, Epoxomicin is a potent, cell-permeable, selective and irreversible proteasome inhibitor. More potent inhibitor of the chymotrypsin-like activity of the proteasome than Lactacystin. Blocks also trypsin-like and PGPH activities of the proteasome. Group: Biochemicals. Grades: Highly Purified. CAS No. 134381-21-8. Pack Sizes: 50ug, 250ug. US Biological Life Sciences. | Worldwide |
| equine arterivirus serine peptidase | In the equine arterivirus (EAV), the replicase gene is translated into open reading frame 1a (ORF1a) and ORF1ab polyproteins. This enzyme is the main viral proteinase and processes five cleavage sites in the ORF1a protein and three in the ORF1b-encoded part of the ORF1ab protein to yield nonstructural proteins (nsp5-nsp12). It combines the catalytic system of a chymotrypsin-like serine peptidase (His-Asp-Ser catalytic triad) with the substrate specificity of a 3C-like serine peptidase (Glu or Gln) at the P1 position and a small amino-acid residue (Gly, Ser or Ala) at the P1' position. Cleavage of ORF1ab by this enzyme is essential for viral replication. Belongs in peptidase family S32. Group: Enzymes. Enzyme Commission Number: EC 3.4.21.114. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4109; equine arterivirus serine peptidase; EC 3.4.21.114. Cat No: EXWM-4109. | |
| Estatin A | Estatin A is a thiol protease inhibitor produced by Mycellophthora thermophila M4323. It has strong inhibitory activity of papain, fig protease and bromelain, but does not inhibit chymotrypsin, trypsin and pepsin. Synonyms: Oxiranecarboxylic acid, 3- ( ( (2- ( (4- ( (aminoiminomethyl)amino)butyl)amino)-2-oxo-1- (phenylmethyl)ethyl)amino)carbonyl)-. Molecular formula: C18H25N5O5. Mole weight: 391.42. | |
| Estatin B | Estatin B is a thiol protease inhibitor produced by Mycellophthora thermophila M4323. It has strong inhibitory activity of papain, fig protease and bromelain, but does not inhibit chymotrypsin, trypsin and pepsin. Synonyms: Oxiranecarboxylic acid, 3- ( ( (2- ( (4- ( (aminoiminomethyl)amino)butyl)amino)-1- ( (4-hydroxyphenyl)methyl)-2-oxoethyl)amino)carbonyl)-. CAS No. 106396-24-1. Molecular formula: C18H25N5O6. Mole weight: 407.42. | |
| flavivirin | Known from classical flaviviruses (yellow fever, dengue fever). The functional viral peptidase is part of the NS2B protein. Catalytic His, Asp and Ser residues are arranged as in chymotrypsin, but flavivrin is the type example of peptidase family S7. Group: Enzymes. Synonyms: Yellow fever virus (flavivirus) protease; NS2B-3 proteinase. Enzyme Commission Number: EC 3.4.21.91. CAS No. 154215-26-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4183; flavivirin; EC 3.4.21.91; 154215-26-6; Yellow fever virus (flavivirus) protease; NS2B-3 proteinase. Cat No: EXWM-4183. | |
| GW311616 | Potent, selective and orally active human neutrophil elastase (HNE) inhibitor (IC50 value 22 nM). GW311616A is selective over other human serine proteases (IC50 values >100 μM for trypsin, cathepsin G, and plasmin, >3 μM for chymotrypsin and tissue plasminogen activator), and does not inhibit AchE at 100 μM. Synonyms: GW-311616; GW 311616. Grades: >98%. CAS No. 198062-54-3. Molecular formula: C19H31N3O4S. Mole weight: 397.53. | |
| GW311616 hydrochloride | Potent, selective and orally active human neutrophil elastase (HNE) inhibitor (IC50 value 22 nM). GW311616A is selective over other human serine proteases (IC50 values >100 μM for trypsin, cathepsin G, and plasmin, >3 μM for chymotrypsin and tissue plasminogen activator), and does not inhibit AchE at 100 μM. Synonyms: GW-311616 hydrochloride; GW 311616 hydrochloride; GW311616A. Grades: >98%. CAS No. 197890-44-1. Molecular formula: C19H32ClN3O4S. Mole weight: 433.99. | |
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