Chymotrypsin Suppliers USA
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Product | Description | |
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Chymotrypsin 1000usp-E/m Quick inquiry Where to buy Suppliers range | Chymotrypsin 1000usp-E/m. | CA, FL & NJ |
Chymotrypsin BRP Quick inquiry Where to buy Suppliers range | Chymotrypsin BRP. Uses: For analytical and research use. Group: European Pharmacopoeia (Ph. Eur.); Pharmacopoeial Standards. Alternative Names: Chymotrypsin. CAS No. 9004-7-3. Catalog: APS9004073A. Format: Neat. Product Type: Other. Shipping: Room Temperature. | |
Chymotrypsin (EP) Quick inquiry Where to buy Suppliers range | Chymotrypsin (EP). Uses: For analytical and research use. Group: Enzyme Activators, Inhibitors & Substrates. Alternative Names: Chymotrypsin. CAS No. 9004-7-3. Catalog: APS9004073. Format: Neat. Product Type: Other. Shipping: Room Temperature. | |
Chymotrypsin Substrate I, Colorimetric Quick inquiry Where to buy Suppliers range | Chymotrypsin Substrate I, Colorimetric is a substrate for the assay of chymotrypsin activity and for S. griseus protease B. Contains 90 mg D-mannitol and 10 mg substrate. Group: Biochemicals. Grades: Highly Purified. CAS No. 68982-90-1. Pack Sizes: 10mg, 25mg. Molecular Formula: C23H25N5O8, Molecular Weight: 499.47. US Biological Life Sciences. | Worldwide |
a-Chymotrypsin Quick inquiry Where to buy Suppliers range | a-Chymotrypsin. Group: Biochemicals. Grades: Highly Purified. CAS No. 9004-7-3. Pack Sizes: 2g, 5g, 10g, 25g, 50g. US Biological Life Sciences. | Worldwide |
alpha-Chymotrypsin from bovine pancreas Quick inquiry Where to buy Suppliers range | alpha-Chymotrypsin from bovine pancreas. Group: Biochemicals. Alternative Names: TLCK-Chymotrypsin. Grades: Highly Purified. CAS No. 9004-3-7. Pack Sizes: 500mg, 1g, 2g, 5g. US Biological Life Sciences. | Worldwide |
1-Methyl-1H-benzotriazole Quick inquiry Where to buy Suppliers range | A benzotriazole derivative with potential inhibitory effect on protease enzymes chymotrypsin, trypsin and papain. Group: Biochemicals. Grades: Highly Purified. CAS No. 13351-73-0. Pack Sizes: 1g, 2.5g. Molecular Formula: C7H7N3. US Biological Life Sciences. | Worldwide |
1-Methyl-1H-benzotriazole-d3 Quick inquiry Where to buy Suppliers range | 1-Methyl-1H-benzotriazole-d3 is the labeled derivative of 1-Methyl-1H-benzotriazole (M289810), which is the benzotriazole derivative with potential inhibitory effect on protease enzymes chymotrypsin, trypsin and papain. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1g, 10g. Molecular Formula: C7H4D3N3, Molecular Weight: 136.169999999999. US Biological Life Sciences. | Worldwide |
2,4-Difluorobenzoic Acid-d3 Quick inquiry Where to buy Suppliers range | 2,4-Difluorobenzoic Acid-d3, is the labeled analogue of 2,4-Difluorobenzoic Acid (D445710). 2,4-Difluorobenzoic Acid-d3, can be used for the synthesis of N2-Acetyl-N-(4-fluorobenzyl)carbazyl-α-chymotrypsin, which resembles the acylated enzyme intermediate formed during reaction of Chymotrypsine with substrate derived from phenylalanine. Group: Biochemicals. Grades: Highly Purified. CAS No. 1219804-63-3. Pack Sizes: 50mg, 500mg. Molecular Formula: C7HD3F2O2, Molecular Weight: 161.12. US Biological Life Sciences. | Worldwide |
3,3'-Diamino-4'-methoxyflavone, DD1 (3-amino-2-(3-amino-4-methoxyphenyl)-4H-chromen-4-one, p76S6 Inhibitor, DD1, Proteasome Inhibitor, DD1) Quick inquiry Where to buy Suppliers range | A cell-permeable flavone derivative that arrests the proliferation of acute myeloid leukemia cells (NB4, U937, HL-60, OCI AML3), in a dose and time-dependent manner (optimum at ~20uM and 96h) and blocks the colony formation in samples from acute myeloid leukemia patients, without affecting normal blood cells. Shown to reduce mitochondrial membrane potential and Bad phosphorylation (at Ser136), induce Bax and caspase 3, 8, and 9 activation in U937 cells. Does not affect the phosphorylation of Akt1, but significantly reduces the expression and phosphorylation of p70S6 kinase in U937 cells. Reported to inhibit the chymotrypsin-like activity of proteasome (IC50 = 2.0uM) and this effect is synergistic with bortezomib. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
6-Aminohexanoic acid (EACA) Quick inquiry Where to buy Suppliers range | 6-Aminohexanoic Acid is a reagent commonly used for the extraction of aldehydes from reaction mixtures. 6-Aminohexanoic Acid has also been shown to improve solubilization of membrane proteins in electrophoresis. Studies suggest that 6-Aminohexanoic Acid inhibits the activation of the first component of the complement system.EACA is reported to inhibit chymotrypsin, Factor VIIa, lysine carboxypeptidase, plasmin, and plasminogen activator. Lysine analog. Promotes rapid dissociation of plasmin, thereby inhibiting the activation of plasminogen and subsequent fibrinolysis. Reported to inhibit plasminogen binding to activated platelets. An early report indicated that it inhibits the activation of the first component of the complement system. Binds and inactivates Carboxypeptidase B. Group: Biochemicals. Alternative Names: 6-Amino-n-hexanoic Acid; 6-Aminocaproic Acid; 6-Aminohexanoic Acid; A 14719; ACS; Acepramin; Acepramine; Acikaprin; Afibrin; Amicar; Amikar; Aminokapron; CL 10304; CY 116; Caplamin; Capramol; Caprocid; Caprolisin; EACA; EACS; Epsamon; Epsicapron; Epsikapron; Epsilcapramin; Epsilon S; Hemocaprol; Hemopar; Hepin; Ipsilon; NSC 212532; NSC 26154; NSC 400230; Respramin; ε-Amino-n-caproic Acid; ε-Amino-n-hexanoic Acid; ε-Aminocaproic Acid; ε-Aminohexanoic Acid; ε-Leucine; ε-Norleucine; ω-Aminocaproic Acid; ω-Aminohexanoic Acid. Grades: Highly Purified. CAS No. 60-32-2. Pack Sizes: 500g, 1Kg. Molecular Formula: C6H13NO2, Molecular Weight: 131.17. US Biological Life Sciences. | Worldwide |
6-N-Biotinylaminohexyl Isopropyl Phosphorofluoridate, Hemihydrate Quick inquiry Where to buy Suppliers range | A potent tool for the inhibition and isolation of Serine Esterases and Proteases. Also a potent inhibitor of a-chymotrypsin. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
7-(N-Benzyloxycarbonylglycyl-glycyl-leucyl)amino-4-methylcoumarin Quick inquiry Where to buy Suppliers range | 7-(N-Benzyloxycarbonylglycyl-glycyl-leucyl)amino-4-methylcoumarin is a fluorogenic substrate for the chymotrypsin-like activity of the 20S proteasome. Synonyms: 7-Z-Gly-gly-leu-ME; L-Leucinamide, N-[ (phenylmethoxy)carbonyl]glycylglycyl-N- (4-methyl-2-oxo-2H-1-benzopyran-7-yl)-; Z-GGL-AMC. Grades: ≥98%. CAS No. 97792-39-7. Molecular formula: C28H32N4O7. Mole weight: 536.58. | |
Ac-Ala-Asn-Trp-AMC (Ac-ANW-AMC) Quick inquiry Where to buy Suppliers range | Ac-ANW-AMC is a fluorogenic peptide substrate and used for measuring chymotrypsin-like activity of the immunoproteasome.This substrate is specific to the immunoproteasome, and is not hydrolyzed efficiently by the constitutive proteasome. Cleavage of this peptide by the immunoproteasome or other enzymes liberates the fluorophore AMC causing a strong fluorescent signal which is detected at an Excitation wavelength of 345nm and Emission wavelength of 445nm. Uses: Peptide Inhibitors. Product ID: R0951. | |
Ac-ANW-AMC Quick inquiry Where to buy Suppliers range | Ac-ANW-AMC is a 7-amino-4-methylcoumarin labelled fluorogenic peptidyl substrate and used for measuring chymotrypsin-like activity of the immunoproteasome. Synonyms: (S)-N1-((S)-3-(1H-indol-3-yl)-1-((4-methyl-2-oxo-2H-chromen-7-yl)amino)-1-oxopropan-2-yl)-2-((S)-2-acetamidopropanamido)succinamide; N-Acetyl-L-alanyl-L-asparaginyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)-L-tryptophanamide; Acetyl-Ala-Asn-Trp-7-amido-4-methylcoumarin. Grades: >99%. Molecular formula: C30H32N6O7. Mole weight: 588.61. | |
Acetyl-3-(2-naphthyl)-D-alanine Quick inquiry Where to buy Suppliers range | Acetyl-3-(2-naphthyl)-D-alanine was used to study the aromatic binding site of α-chymotrypsin. It was used to design an asymmetric synthesis of a new cylindrically chiral and air-stable ferrocenyldiphosphine and its application to rhodium-catalyzed asymmetric hydrogenation. Synonyms: Ac-D-Ala(2-naphthyl)-OH; (R)-N-Acetyl-2-naphthylalanine; Ac-D-2-Nal-OH; (R)-2-ACETAMIDO-3-(NAPHTHALEN-2-YL)PROPANOIC ACID; N-Acetyl-3-(2-naphthyl)-D-alanine; 2-Naphthalenepropanoic acid, a-(acetylamino)-, (aR)-; Ac-D-Ala(2-Naph)-OH. Grades: ≥ 98% (HPLC). CAS No. 37440-01-0. Molecular formula: C15H15NO3. Mole weight: 257.28. | |
Acetyl-L-phenylalanine methyl ester Quick inquiry Where to buy Suppliers range | A substrate for chymotrypsin. Synonyms: Ac-L-Phe-Ome; Methyl N-acetyl-L-phenylalaninate. Grades: ≥ 99% (HPLC). CAS No. 3618-96-0. Molecular formula: C12H15NO3. Mole weight: 221.30. | |
Acetyl-L-tyrosine ethyl ester hydrate Quick inquiry Where to buy Suppliers range | A substrate for chymotrypsin and carboxypeptidase Y. Synonyms: Ac-L-Tyr-OEt H2O; Ethyl N-acetyl-L-tyrosinate hydrate. Grades: ≥ 99.0% (HPLC). CAS No. 36546-50-6. Molecular formula: C13H17NO4·H2O. Mole weight: 269.30. | |
Ac-Nle-Pro-Nle-Asp-AMC Quick inquiry Where to buy Suppliers range | Ac-Nle-Pro-Nle-Asp-AMC is a substrate for proteasomes. It can be cleaved by the caspase-like site of proteasome, also known as postglutamyl peptide hydrolase (PGPH). AMC (7-amino-4-methylcoumarin) is released and produces the fluorescence utilized to quantify the caspase-like site activity. Ac-Nle-Pro-Nle-Asp-AMC also inhibits the chymotrypsin-like activity of the proteasome allosterically when bound to the caspase-like site. Synonyms: Ac-Nle-Pro-Nle-Asp-7-amido-4-Methylcoumarin; Ac-nLPnLD-AMC; N-acetyl-L-norleucyl-L-prolyl-L-norleucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-α-asparagine; L-α-Asparagine, N-acetyl-L-norleucyl-L-prolyl-L-norleucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-; (3S) -4-Hydroxy-3- ({ (2S) -1-hydroxy-2-[ (hydroxy{ (2S) -1-[N- (1-hydroxyethylidene) -L-norleucyl]-2-pyrrolidinyl}methylene) amino]hexylidene}amino) -4-[ (4-methyl-2-oxo-2H-chromen-7-yl) imino]butanoic acid. Grades: ≥98%. CAS No. 355140-49-7. Molecular formula: C33H45N5O9. Mole weight: 655.74. | |
Ac-Trp-Leu-Ala-AMC Quick inquiry Where to buy Suppliers range | A fluorogenic peptid substrate used for measuring chymotrypsin-like activity of the proteasome. Hydrolysis of this substrate by the β5 subunit of the 20S proteasome is monitored by observing fluorescence at an Excitation wavelength of 345nm and Emission at 445nm. Uses: Peptide Inhibitors. Product ID: R1034. | |
AEBSF HCl Quick inquiry Where to buy Suppliers range | AEBSF is a water-soluble, irreversible serine protease inhibitor that inhibits proteases like chymotrypsin, kallikrein, plasmin, thrombin, and trypsin. Synonyms: 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride; AEBSF hydrochloride; AEBSF. Grades: 98%. CAS No. 30827-99-7. Molecular formula: C8H11ClFNO2S. Mole weight: 239.69. | |
Ala-Ala-Phe-pNA Quick inquiry Where to buy Suppliers range | Substrate for chymotrypsin and tripeptidyl peptidase I. Synonyms: Ala-Ala-Phe p-nitroanilide. Grades: ≥ 99% (Assay). CAS No. 61043-41-2. Molecular formula: C21H25N5O5. Mole weight: 427.46. | |
α-Bromo-N-benzyl-N-methylacetamide Quick inquiry Where to buy Suppliers range | An α-bromo amides that inactivates α-chymotrypsin. Group: Biochemicals. Alternative Names: N-(Bromoacetyl)-N-methylbenzylamine; N-Methyl-N-benzyl-2-bromoacetamide; N-Methyl-N-benzylbromoacetamide. Grades: Highly Purified. CAS No. 73391-96-5. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
AM-114 Quick inquiry Where to buy Suppliers range | AM 114 is an inhibitor of chymotrypsin-like activity of the 20S proteasome. In addition, AM-114 shows anticancer activity, It can inhibit cell growth in human colon cancer HCT116 p53+/+ cells. Uses: Anticancer. Synonyms: AM-114; AM 114; AM114; Proteasome Inhibitor IX; ( (1Z, 1'Z)- (1-methyl-4-oxopiperidine-3, 5-diylidene)bis (methanylylidene))bis (4, 1-phenylene))diboronic acid. Grades: 98%. CAS No. 856849-35-9. Molecular formula: C20H21B2NO5. Mole weight: 377.01. | |
Antifungal protein J Quick inquiry Where to buy Suppliers range | Antifungal protein J is an antimicrobial peptide found in Solanum tuberosum (Potato). It has antifungal activity and is an inhibitor of serine proteases chymotrypsin, pepsin and trypsin. Synonyms: AFP-J; Leu-Pro-Ser-Asp-Ala-Thr-Leu-Val-Leu-Asp-Gln-Thr-Gly-Lys-Glu-Leu-Asp-Ala-Arg-Leu. Grades: ≥96%. Molecular formula: C93H159N25O33. Mole weight: 2155.43. | |
Aprotinin, Bovine (Pancreatic trypsin inhibitor) Quick inquiry Where to buy Suppliers range | Aprotinin is a competitive serine protease inhibitor that inhibits trypsin, chymotrypsin, kallikrein and plasmin. Aprotinin forms stable complexes with and blocks the active sites of enzymes. Binding is reversible with most aprotinin-protease complexes, dissociating at pH >10 or <3. Effective concentration is equimolar with protease. Group: Biochemicals. Alternative Names: Antikrein; Antilysin; Antilysine; Aprostat; Aprotinin; BPTI; BPTI Trypsin Inhibitor; Basic Pancreatic Trypsin Inhibitor; Bayer A 128; Bovine Basic Pancreatic Trypsin Inhibitor; Bovine Pancreatic Trypsin Inhibitor; Bovine Trypsin Inhibitor; Fosten; Kallikrein-trypsin Inactivator; Kiker 52G; Kir Richter; Kunitz Pancreatic Trypsin Inhibitor; Kunitz Protease Inhibitor; Kunitz Trypsin Inhibitor; Kunitz-type Inhibitor; Kunitz-type Proteinase Inhibitor; Kunitz-type Trypsin Inhibitor; Onquinin; Pancreatic Basic Trypsin Inhibitor; Pancreatic Trypsin Inhibitor; Pancreatic Trypsin Inhibitor (Kunitz); Protease Inhibitor, Kunitz Type; RP 9921; Repulson; Trasuylol; Trasylol; Trazinin; Triazinin; Trypsin Inhibitor, Trasylol; Trypsin-kallikrein Inhibitor (Kunitz); Zymofren. Grades: Highly Purified. CAS No. 9087-70-1. Pack Sizes: 100mg, 250mg, 500mg, 1g. Molecular Formula: C???H???N??O??S?, Molecular Weight: 6511.45. US Biological Life Sciences. | Worldwide |
Benzoyl-L-tyrosine 4-nitroanilide Quick inquiry Where to buy Suppliers range | A substrate for the determination of chymotrypsin activity. Synonyms: Bz-L-Tyr-Pna; (S)-N-(3-(4-Hydroxyphenyl)-1-((4-nitrophenyl)amino)-1-oxopropan-2-yl)benzamide; N-Benzoyl-l-tyrosine p-nitroanilide. CAS No. 6154-45-6. Molecular formula: C22H19N3O5. Mole weight: 405.40. | |
Boc-glycine 4-nitrophenyl ester Quick inquiry Where to buy Suppliers range | A substrate for chymotrypsin and trypsin. Synonyms: Boc-Gly-Onp; 4-nitrophenyl n-(tert-butoxycarbonyl)glycinate; 4-Nitrophenyl N-((1,1-dimethylethoxy)carbonyl)glycinate. Grades: ≥ 98% (TLC). CAS No. 3655-5-8. Molecular formula: C13H16N2O6. Mole weight: 296.30. | |
Bromoenol lactone Quick inquiry Where to buy Suppliers range | BEL is a selective, potent, irreversible, mechanism-based inhibitor of myocardial cytosolic calcium-independent phospholipase A2 (iPLA2) with a Ki value of 180 nM. BEL induces the proteolysis of procaspase-9 and procaspase-3 and increases cleavage of poly (ADP-ribose) polymerase. BEL also inhibits macrophage iPLA2 in a concentration-dependent manner with an IC50 value of 60 nM and is an effective enzyme-activated irreversible inhibitor of chymotrypsin Ki of 636 nM. Long term treatment with BEL increased annexin-V binding to the cell surface and nuclear DNA damage. Synonyms: BEL; Haloenol lactone; HELSS. Grades: ≥95%. CAS No. 88070-98-8. Molecular formula: C16H13BrO2. Mole weight: 317.2. | |
Carfilzomib Quick inquiry Where to buy Suppliers range | Carfilzomib is a tetrapeptide epoxyketone and an analog of epoxomicin, acting as a selective proteasome inhibitor, such as the chymotrypsin-like β5 subunit of the constitutive 20S proteasome (IC50 = 5.2 nM) and the β5i subunit of the immunoproteasome 20Si (LMP7; IC50 = 14 nM). It has been used as an injectable antineoplastic agent (IV only). Synonyms: Kyprolis; PR171; PR-171; PR 171; (2S)-4-methyl-N-[(2S)-1-[[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]-4-phenylbutanoyl]amino]pentanamide. Grades: ≥98%. CAS No. 868540-17-4. Molecular formula: C40H57N5O7. Mole weight: 719.9. | |
Carfilzomib Impurity 13 hydrochloride Quick inquiry Where to buy Suppliers range | Carfilzomib is an anti-cancer drug acting as a selective proteasome inhibitor. Chemically, it is a tetrapeptide epoxyketone and an analog of epoxomicin. It is a second-generation and peptide epoxyketone class proteasome inhibitor that targets the chymotrypsin-like β5 subunit of the constitutive 20S proteasome with IC50 of 5.2 nM. Carfilzomib impurity 13 hydrochloride is a potential impurity found in commercial carfilzomib preparations. Grades: ≥95%. CAS No. 2319881-95-1. Molecular formula: C16H22N2O4·HCl. Mole weight: 342.8. | |
Casein, Carbohydrate and Fatty Acid Free Quick inquiry Where to buy Suppliers range | High molecular weight phosphoprotein. Useful as a substrate for bromelain, chymotrypsin, pepsin, trypsin, and other proteases. Supplied as Hammarsten grade material. Uses: ·Nutritional supplements ·Raw material of food ·Paint, wood glue, plastic fiber ·Dentist materials ·General analytical. Group: Animal Hydrocolloids. CAS No. 9000-71-9. Molecular Weight: 2061.96 g/mol. Boiling Point: 280 °C (dec.) (lit.). Flash Point: ≥70 %. Purity: 1.26 g/cm3. Density: Dilute base: 10 mg/mL. | |
Cathepsin G Inhibitor I Quick inquiry Where to buy Suppliers range | Cathepsin G inhibitor I is a potent and selective inhibitor of cathepsin G with IC50 of 53 nM. It weakly inhibits chymotrypsin and poorly inhibits thrombin, factor Xa, factor IXa, plasmin, trypsin, tryptase, proteinase 3, and human leukocyte elastase. Synonyms: Cathepsin G Inhibitor I; 429676-93-7; Cathepsin G Inhibitor; CHEMBL164694; [2-[3-[(1-benzoylpiperidin-4-yl)-methylcarbamoyl]naphthalen-2-yl]-1-naphthalen-1-yl-2-oxoethyl]phosphonic acid; SCHEMBL1613660; DTXSID80431393; BDBM50139754; HY-103351; CS-0027703; A918760; (2-{3-[(1-Benzoyl-piperidin-4-yl)-methyl-carbamoyl]-naphthalen-2-yl}-1-naphthalen-1-yl-2-oxo-ethyl)-phosphonic acid; [2-[3-[(1-benzoylpiperidin-4-yl)-methylcarbamoyl]naphthalen-2-yl]-1-naphthalen-1-yl-2 oxoethyl]phosphonic acid. Grades: ≥95%. CAS No. 429676-93-7. Molecular formula: C36H33N2O6P. Mole weight: 620.6. | |
CEP-7055 Quick inquiry Where to buy Suppliers range | CEP-18770 is An orally bioavailable synthetic P2 threonine boronic acid inhibitor of the chymotrypsin-like activity of the proteasome, with potential antineoplastic activity. Proteasome inhibitor CEP 18770 represses the proteasomal degradation of a variety of proteins, including inhibitory kappaBalpha (IkappaBalpha), resulting in the cytoplasmic sequestration of the transcription factor NF-kappaB; inhibition of NF-kappaB nuclear translocation and transcriptional up-regulation of a variety of cell growth-promoting factors; and apoptotic cell death in susceptible tumor cell populations. In vitro studies indicate that this agent exhibits a favorable cytotoxicity profile toward normal human epithelial cells, bone marrow progenitors, and bone marrow-derived stromal cells relative to the proteasome inhibitor bortezomib. The intracellular protein IkappaBalpha functions as a primary inhibitor of the proinflammatory transcription factor NF-kappaB. Synonyms: CEP 7055; CEP7055; 3-(9-isopropoxymethyl-5-oxo-6,7,12,13-tetrahydro-5H-indeno[2,1-a]pyrrolo[4,3-c]carbazol-12-yl)propyl 2-dimethylaminoacetate. CAS No. 402857-58-3. Molecular formula: C32H35N3O4. Mole weight: 525.65. | |
CH 5450 Quick inquiry Where to buy Suppliers range | Z-Ile-Glu-Pro-Phe-Ome is a peptide inhibitor of human heart chymase which is a chymotrypsin-like enzyme that converts angiotensin I to angiotensin II. Synonyms: ZIEPF-Ome; N-benzyloxycarbonyl-L-isoleucyl-L-alpha-glutamyl-L-prolyl-L-phenylalanine methyl ester; Cbz-Ile-Glu-Pro-Phe-OMe; CH5450; CH-5450. Grades: ≥95%. CAS No. 252557-97-4. Molecular formula: C34H44N4O9. Mole weight: 652.73. | |
Chymostatin Quick inquiry Where to buy Suppliers range | Chymostatin is a bioactive peptide that acts as a protease inhibitor with selectivity for chymotryptase-like serine proteases. It potently inhibits chymotrypsin and chymase, but it cannot block the activity of cathepsins, papain, and leukocyte elastase effectively. It doesn't have effect on trypsin, thrombin, plasmin, pepsin, and kallikrein. Uses: Serine proteinase inhibitors. Synonyms: [(S)-1-Carboxy-2-phenylethyl]-carbamoyl-a-[2-amidohexahydro-4(S)-pyrimidyl]-(S)-glycyl-[A= Leu B=Val C=Ile]-phenylalaninal (Mixture). Grades: ≥95% (a mixture of A, B, C). CAS No. 9076-44-2. Molecular formula: CxHyN7O6. Mole weight: 607.7. | |
Chymostatin A Quick inquiry Where to buy Suppliers range | It is produced by the strain of Streptomyces hygroscopicus and Str.lavendulae. Chymostatin A can be used to inhibit chymotrypsin, papain and other serine/cysteine endopeptidase. Molecular formula: C31H41N7O6. Mole weight: 607.70. | |
Clasto-Lactacystin beta-lactone (Omuralide) Quick inquiry Where to buy Suppliers range | In vitro lactacystin does not react with the proteasome. It rather undergoes a spontaneous conversion (lactonization) to the active metabolite clasto-lactacystin beta-lactone. Potent and selective irreversible and cell permeable proteasome inhibitor. Inhibits the chymotrypsin-like, trypsin-like and caspase-like peptidase activity of the proteasome. The active metabolite of lactacystin with higher potency since it does not require hydrolysis in order to become cell permeable. Calpain and cathepsin inhibitor. Apoptosis inducer. Anticancer compound. Induces differentiation and inhibits cell cycle progression in several tumor cell lines. Induces neuritogenesis. Autophagy inducer. Group: Biochemicals. Grades: Highly Purified. CAS No. 154226-60-5. Pack Sizes: 100ug. Molecular Formula: C10H15NO4, Molecular Weight: 213.2. US Biological Life Sciences. | Worldwide |
Delanzomib Quick inquiry Where to buy Suppliers range | Delanzomib, also known as CEP-18770, is An orally bioavailable synthetic P2 threonine boronic acid inhibitor of the chymotrypsin-like activity of the proteasome, with potential antineoplastic activity. Proteasome inhibitor CEP 18770 represses the proteasomal degradation of a variety of proteins, including inhibitory kappaBalpha (IkappaBalpha), resulting in the cytoplasmic sequestration of the transcription factor NF-kappaB; inhibition of NF-kappaB nuclear translocation and transcriptional up-regulation of a variety of cell growth-promoting factors; and apoptotic cell death in susceptible tumor cell populations. In vitro studies indicate that this agent exhibits a favorable cytotoxicity profile toward normal human epithelial cells, bone marrow progenitors, and bone marrow-derived stromal cells relative to the proteasome inhibitor bortezomib. The intracellular protein IkappaBalpha functions as a primary inhibitor of the proinflammatory transcription factor NF-kappaB. Uses: Proteasome inhibitors. Synonyms: CEP18770; CEP 18770; CEP-18770; Delanzomib. CAS No. 847499-27-8. Molecular formula: C21H28BN3O5. Mole weight: 413.27. | |
Dihydroeponemycin Quick inquiry Where to buy Suppliers range | Dihydroeponemycin is a natural, irreversible inhibitor of proteasomal degradation of proteins that acts by binding the IFN-γ-inducible proteins LMP2 and LMP7, as well as the constitutive proteasome subunit X. It does not inhibit calpain or trypsin and has minor effects on cathepsin B and chymotrypsin at higher concentrations. It is cell-permeable and induces apoptosis in bovine aortic endothelial cells. Grades: ≥98%. CAS No. 126463-64-7. Molecular formula: C20H36N2O6. Mole weight: 400.5. | |
Elasnin Quick inquiry Where to buy Suppliers range | Elasnin is isolated from certain strains of Streptomyces. Elasnin is a reversible inhibitor of elastase with IC50 values of 1.3 and 30 μg/ml for human granulocyte and pancreatic enzymes, respectively. It inhibits human leukocyte elastase, porcine pancreatic elastase, and chymotrypsin with Ki values of 93, 69 and 224 μM, respectively. Synonyms: 3,5-dibutyl-2-hydroxy-6-(6-oxoundecan-5-yl)-4H-pyran-4-one; 3,?5-Dibutyl-6-(1-butyl-2-oxoheptyl)?-4-hydroxy-2H-pyran-2-one. Grades: ≥98%. CAS No. 68112-21-0. Molecular formula: C24H40O4. Mole weight: 392.57. | |
Elasnin (3,5-Dibutyl-4-hydroxy-6-(6-oxoundecan-5-yl)-2H-pyran-2-one) Quick inquiry Where to buy Suppliers range | Inhibitor of human leukocyte elastase (IC50=1.3ug/ml), different other elastases and chymotrypsin (IC50=82ug/ml). Group: Biochemicals. Grades: Highly Purified. CAS No. 68112-21-0. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
Epoxomicin Quick inquiry Where to buy Suppliers range | Antibiotic. Potent anticancer compound. Cell permeable, potent, selective and irreversible 20S proteasome inhibitor. Predominantly inhibits the chymotrypsin-like (CTRL) activity of the proteasome. Exhibits lower level inhibition of proteasome trypsin-like and caspase-like activitives (100 and 1,000-fold slower rates respectively). Anti-inflammatory. Antimicrobial and antimalarial. Anti-parasitic. Stimulates bone formation by inhibiting osteoblast proteasome activity. Induces Parkinson's-like symptoms in rats. The ubiquitin-proteasome system (UPS) and autophagy serve as two complementary, reciprocally regulated protein degradation systems. Blockade of UPS by Epoxomicin activates autophagy. Group: Biochemicals. Alternative Names: N-acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N- [ (1S) -3-methyl-1- [ [ (2R) -2-methyloxiranyl] carbonyl] butyl] -L-threoninamide, BU 4061T. Grades: Highly Purified. CAS No. 134381-21-8. Pack Sizes: 50ug, 100ug, 250ug, 500ug. Molecular Formula: C??H??N?O?, Molecular Weight: 554.7. US Biological Life Sciences. | Worldwide |
Epoxomicin (BU-4061T, N-acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N- [ (1S) -3-methyl-1 [ [ (2R) -2-methyloxiranyl] carbonyl] butyl] -L-threoninamide) Quick inquiry Where to buy Suppliers range | Originally isolated from Actinomycetes strain based on its potent in vivo antitumor activity, Epoxomicin is a potent, cell-permeable, selective and irreversible proteasome inhibitor. More potent inhibitor of the chymotrypsin-like activity of the proteasome than Lactacystin. Blocks also trypsin-like and PGPH activities of the proteasome. Group: Biochemicals. Grades: Highly Purified. CAS No. 134381-21-8. Pack Sizes: 50ug, 250ug. US Biological Life Sciences. | Worldwide |
Epoxomicin, Synthetic Quick inquiry Where to buy Suppliers range | Epoxomicin, Synthetic, CAS 134381-21-8, is a potent, specific, and irreversible inhibitor of chymotrypsin-like, trypsin-like, and peptidyl-glutamyl peptide hydrolyzing activities of the proteasome. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 100μG. Mole weight: 554.72. Catalog: IAR42410900. Assay: ≥95% (HPLC). | |
Estatin A Quick inquiry Where to buy Suppliers range | Estatin A is a thiol protease inhibitor produced by Mycellophthora thermophila M4323. It has strong inhibitory activity of papain, fig protease and bromelain, but does not inhibit chymotrypsin, trypsin and pepsin. Synonyms: Oxiranecarboxylic acid, 3- ( ( (2- ( (4- ( (aminoiminomethyl)amino)butyl)amino)-2-oxo-1- (phenylmethyl)ethyl)amino)carbonyl)-. Molecular formula: C18H25N5O5. Mole weight: 391.42. | |
Estatin B Quick inquiry Where to buy Suppliers range | Estatin B is a thiol protease inhibitor produced by Mycellophthora thermophila M4323. It has strong inhibitory activity of papain, fig protease and bromelain, but does not inhibit chymotrypsin, trypsin and pepsin. Synonyms: Oxiranecarboxylic acid, 3- ( ( (2- ( (4- ( (aminoiminomethyl)amino)butyl)amino)-1- ( (4-hydroxyphenyl)methyl)-2-oxoethyl)amino)carbonyl)-. CAS No. 106396-24-1. Molecular formula: C18H25N5O6. Mole weight: 407.42. | |
GW311616 Quick inquiry Where to buy Suppliers range | Potent, selective and orally active human neutrophil elastase (HNE) inhibitor (IC50 value 22 nM). GW311616A is selective over other human serine proteases (IC50 values >100 μM for trypsin, cathepsin G, and plasmin, >3 μM for chymotrypsin and tissue plasminogen activator), and does not inhibit AchE at 100 μM. Synonyms: GW-311616; GW 311616. Grades: >98%. CAS No. 198062-54-3. Molecular formula: C19H31N3O4S. Mole weight: 397.53. | |
GW311616 hydrochloride Quick inquiry Where to buy Suppliers range | Potent, selective and orally active human neutrophil elastase (HNE) inhibitor (IC50 value 22 nM). GW311616A is selective over other human serine proteases (IC50 values >100 μM for trypsin, cathepsin G, and plasmin, >3 μM for chymotrypsin and tissue plasminogen activator), and does not inhibit AchE at 100 μM. Synonyms: GW-311616 hydrochloride; GW 311616 hydrochloride; GW311616A. Grades: >98%. CAS No. 197890-44-1. Molecular formula: C19H32ClN3O4S. Mole weight: 433.99. | |
Isatoic Anhydride Quick inquiry Where to buy Suppliers range | Isatoic anhydride is a potent inactivator of α-chymotrypsin and inactivates stoichiometrically. Isatoic Anhydride is an important compound in the preparation of serine protease inhibitors. Group: Biochemicals. Alternative Names: 2H-3,1-Benzoxazine-2,4(1H)-dione; 1,2-Dihydro-3,1-benzoxazine-2,4-dione; 1H-Benz[d][1,3]oxazine-2,4-dione; 2,4-Dioxo-1,2-dihydro-4H-3,1-benzoxazine; 3,1-Benzoxazine-2,4(1H)-dione; 2-(Carboxyamino)benzoic Acid Cyclic Anhydride; Isatoic Acid Anhydride; NSC 104662; NSC 29555. Grades: Highly Purified. CAS No. 118-48-9. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
Lactacystin Quick inquiry Where to buy Suppliers range | Cell-permeable. A potent and selective inhibitor of the 20S proteasome. Binds irreversibly to the active site N-terminal threonine residue of the catalytic beta-subunit of the 20S proteasome, thereby inhibiting its chymotrypsin and trypsin- like activities. Induces neurite outgrowth in Neuro 2A neuroblastoma cells and has been reported to induce apoptosis in human monoblast U937 cells. Also inhibits NF-kB activation (IC50 = 10uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 133343-34-7. Pack Sizes: 200ug. US Biological Life Sciences. | Worldwide |
L-Norlevaline-4-nitoranilide hydrobromide Quick inquiry Where to buy Suppliers range | Substrate for elastase, trypsin and chymotrypsin. Synonyms: L-Nva-pNA HBr. Grades: ≥ 98%. CAS No. 213271-08-0. Molecular formula: C11H15N3O3·HBr. Mole weight: 318.17. | |
MeO-Suc-Arg-Pro-Tyr-pNA Quick inquiry Where to buy Suppliers range | MeO-Suc-Arg-Pro-Tyr-pNA is a substrate for Chymotrypsin. Uses: API. Product ID: 10-101-347. | |
MG-115 Substrate Inhibitor, Z-LLNVa-CHO (Z-Leu-Leu-NVa-CHO) Quick inquiry Where to buy Suppliers range | A potent, reversible proteasome inhibitor with Ki of 21nM for 20S proteasome and 35nM for 26S proteasome. The inhibition of proteasome was through specific inhibition of chymotrypsin-like activity of the proteasome. Also shown to induce apoptosis in Rat-1 and PC12 cells via a p3-independent pathway. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
Nα-Acetyl-L-tryptophan 4-nitrophenyl ester Quick inquiry Where to buy Suppliers range | A substrate for chymotrypsin. Synonyms: Ac-L-Trp-ONp; ACETYL-L-TRYPTOPHAN 4-NITROPHENYL ESTER; AC-TRYPTOPHAN-ONP. Grades: ≥ 98% (TLC). CAS No. 14009-92-8. Molecular formula: C19H17N3O5. Mole weight: 367.40. | |
Nα-Acetyl-L-tryptophan ethyl ester Quick inquiry Where to buy Suppliers range | A substrate for chymotrypsin and carboxypeptidase Y. Synonyms: Ac-L-Trp-OEt; ethyl(2S)-2-acetamido-3-(1H-indol-3-yl)propanoate; N-Acetyl-L-tryptophan ethyl ester; N-Ac-Trp-O-Et; N-Acetyl-L-tryptophan ethyl estert; L-Tryptophan, N-acetyl-, ethyl ester; N-Acetyltryptophan ethyl ester. Grades: ≥ 99% (HPLC). CAS No. 2382-80-1. Molecular formula: C15H18N2O3. Mole weight: 274.30. | |
Nα-Acetyl-L-tryptophan methyl ester Quick inquiry Where to buy Suppliers range | A substrate for chymotrypsin. Synonyms: Ac-L-Trp-OMe; AC-TRYPTOPHAN-OME; N-Acetyl-L-Tryptophan Methyl Ester; methyl(2S)-2-acetamido-3-(1H-indol-3-yl)propanoate; ACETYL-L-TRYPTOPHAN METHYL ESTER; (-)-1-acetyl-L-tryptophan methyl ester. Grades: ≥ 98% (HPLC). CAS No. 2824-57-9. Molecular formula: C14H16N2O3. Mole weight: 260.30. | |
N-Succinyl-Gly-Gly-Phe-p-nitroanilide Quick inquiry Where to buy Suppliers range | N-Succinyl-Gly-Gly-Phe-p-nitroanilide is a substrate for the assay of chymotrypsin activity. Synonyms: Suc-Gly-Gly-Phe-Pna; N-(3-Carboxypropionyl)glycylglycyl-N-(p-nitrophenyl)-3-phenyl-L-alaninamide; N-Suc-Gly-Phe-4-nitroanilide; N-Succinylglycyl-phenylalanine-4-nitroanilide. CAS No. 68982-90-1. Molecular formula: C23H25N5O8. Mole weight: 499.47. | |
Phenylmethylsulfonyl fluoride 99+% (PMSF) (GC) Quick inquiry Where to buy Suppliers range | Phenylmethylsulfonyl Fluoride Is a Phospholipase C inhibitor that ameliorates post-ischemic neuronal damage, nonspecific irreversible inhibitor of serine protease and other enzymes, including trypsin, chymotrypsin, thrombin and papain. Protease Inhibitors, detecting and measuring antibodies in human intestinal aspirate. Group: Biochemicals. Alternative Names: α-Toluenesulfonyl Fluoride; Benzylsulfonyl Fluoride; NSC 88499; PMSF; Phenylmethanesulfonyl Fluoride. Grades: Highly Purified. CAS No. 329-98-6. Pack Sizes: 5g, 25g, 100g. Molecular Formula: C?H?FO?S, Molecular Weight: 174.19. US Biological Life Sciences. | Worldwide |
Phenylmethylsulfonyl Fluoride (PMSF) Quick inquiry Where to buy Suppliers range | Phenylmethylsulfonyl Fluoride Is a Phospholipase C inhibitor that ameliorates post-ischemic neuronal damage, nonspecific irreversible inhibitor of serine protease and other enzymes, including trypsin, chymotrypsin, thrombin and papain. Protease Inhibitors, detecting and measuring antibodies in human intestinal aspirate. Group: Biochemicals. Alternative Names: α-Toluenesulfonyl Fluoride; Benzylsulfonyl Fluoride; NSC 88499; PMSF; Phenylmethanesulfonyl Fluoride. Grades: Highly Purified. CAS No. 329-98-6. Pack Sizes: 10g, 25g, 50g, 100g. Molecular Formula: C?H?FO?S, Molecular Weight: 174.19. US Biological Life Sciences. | Worldwide |
Phosphoramidon Disodium Salt Quick inquiry Where to buy Suppliers range | Phosphoramidon is a powerful inhibitor of thermolysin without inhibiting the other endopeptidases such as trypsin, papain, chymotrypsin. Synonyms: N-(alpha-Rhamno-pyranosyl-phos-phono)-L-leucyl-L-tryptophan disodium salt; L-Tryptophan, N- ( ( (6-deoxy-alpha-L-mannopyranosyl) oxy) hydroxyphosphinyl) -L-leucyl-, disodium salt. Grades: >98%. CAS No. 164204-38-0. Molecular formula: C23H32N3Na2O10P. Mole weight: 587.47. | |
PMSF Quick inquiry Where to buy Suppliers range | Used as a Protease inhibitor such as Chymotrypsin, Trypsin and Thrombin as well as Acetylcholineesterase. Synonyms: Phenylmethylsulfonyl Fluoride. Grades: ≥ 99% (GC). CAS No. 329-98-6. Molecular formula: C7H7FO2S. Mole weight: 174.19. | |
Proteasome Inhibitor XXI, Z-LLLL-SF (Cbz-Leu-Leu-Leu-Leu-Psi-[CH2SO2]-F, Cbz-Leu4-SF, Cbz-LLLL-SF, Z-Leu4-SF, Z-L4-SF) Quick inquiry Where to buy Suppliers range | A cell-permeable tetrapeptidyl sulfonyl fluoride -based irreversible proteasome inhibitor that selectively inhibits the hydrolysis of Suc-LLVY-AMC by the beta5 chymotrypsin-like activity (IC50 = 7nM using yeast 20S proteasome), while exhibiting much reduced potency against Z-LLE-AMC hydrolysis by the beta1 caspase-like activity or Z-LLR-AMC hydrolysis by the beta2 trypsin-like activity (29% and 75% inhibition, respectively, with 200uM inhibitor). One hour inhibitor treatment at 5uM in HEK cultures is shown to completely abolish beta5 labeling by the proteasome probe MV151, while only partial MV151 blockage is seen with beta1 and beta2 at an inhibitor concentration of 50uM. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. Molecular Formula: C??H??FN?O?S. US Biological Life Sciences. | Worldwide |
Proteasome Substrate III, Fluorogenic Quick inquiry Where to buy Suppliers range | Proteasome Substrate III, Fluorogenic, is a substrate for proteasome. Also acts as a substrate for calpain, chymotrypsin, and ingensin. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 5MG. Mole weight: 763.88. Catalog: IAR42416016. Assay: ≥98% (HPLC). | |
Sivelestat Quick inquiry Where to buy Suppliers range | Sivelestat is a competitive human neutrophil elastase (HNE) inhibitor (IC50 = 44 nM, Ki = 0.2 μM). It also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse (IC50 = 19 to 49 nM). However, it does not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin and cathepsin G even at 100 μM. In in-vivo studies, it suppressed lung hemorrhage in hamster (ID50 = 82 μg/kg) by intratracheal administration and increase of skin capillary permeability in guinea pig (ID50 = 9.6 mg/kg) by intravenous administration, both of which were induced by human neutrophil elastase. Synonyms: EI546; EI 546; EI-546; LY544349; LY 544349; LY-544349; ONO5046; ONO-5046; ONO 5046. Grades: >98%. CAS No. 127373-66-4. Molecular formula: C20H22N2O7S. Mole weight: 434.46. | |
Sivelestat sodium tetrahydrate Quick inquiry Where to buy Suppliers range | Sivelestat is a competitive human neutrophil elastase (HNE) inhibitor (IC50 = 44 nM, Ki = 0.2 μM). It also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse (IC50 = 19 to 49 nM). However, it does not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin and cathepsin G even at 100 μM. In in-vivo studies, it suppressed lung hemorrhage in hamster (ID50 = 82 μg/kg) by intratracheal administration and increase of skin capillary permeability in guinea pig (ID50 = 9.6 mg/kg) by intravenous administration, both of which were induced by human neutrophil elastase. Uses: Serine proteinase inhibitors. Synonyms: EI546 sodium tetrahydrate; EI 546 sodium tetrahydrate; EI-546 sodium tetrahydrate; LY544349 sodium tetrahydrate; LY 544349 sodium tetrahydrate; LY-544349 sodium tetrahydrate; ONO5046 sodium tetrahydrate; ONO 5046 sodium tetrahydrate; ONO-5046 sodium tetrahydrate. Grades: >98%. CAS No. 201677-61-4. Molecular formula: C20H29N2NaO11S. Mole weight: 528.51. | |
SL-01, p53/MDM2 Inhibitor (N-Benzyloxycarbonyl-Lphenylalaninylchloro methyl ketone, ZPCK) Quick inquiry Where to buy Suppliers range | Inhibits the p53-MDM2 interaction (20um). Has also been shown to inhibit bovine chymotrypsin A-y. Group: Biochemicals. Alternative Names: N-Benzyloxycarbonyl-Lphenylalaninylchloro methyl ketone, ZPCK. Grades: Highly Purified. CAS No. 26049-94-5. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
Suc-Ala-Ala-Ala-pNA Quick inquiry Where to buy Suppliers range | N-Succinyl-Ala-Ala-Ala-p-nitroanilide is a chromogenic substrate for chymotrypsin-like serine protease, pancreatic elastase and serine endopeptidase. Group: Biochemicals. Alternative Names: N-Succinyl-L-alanyl-L-alanyl-L-alanine 4-nitroanilide; N-Succinyl-tri-L-alanine 4-nitroanilide. Grades: Highly Purified. CAS No. 52299-14-6. Pack Sizes: 25mg, 50mg, 100mg. Molecular Formula: C19H25N5O8, Molecular Weight: 451.43. US Biological Life Sciences. | Worldwide |
Suc-Ala-Ala-Pro-Phe-AMC Quick inquiry Where to buy Suppliers range | Fluorogenic substrate for chymotrypsin. Synonyms: Suc Ala Ala Pro Phe AMC. Grades: ≥ 99% (HPLC). CAS No. 88467-45-2. Molecular formula: C34H39N5O9. Mole weight: 661.71. | |
Succinyl-L-phenylalanine 4-nitroanilide Quick inquiry Where to buy Suppliers range | A substrate for the determination of chymotrypsin activity. Synonyms: Suc-L-Phe-pNA; 4-({1-Benzyl-2-[(4-Nitrophenyl)Amino]-2-Oxoethyl}Amino)-4-Oxobutanoic Acid; (S)-4-[[2-[(4-Nitrophenyl)Amino]-2-Oxo-1-(Phenylmethyl)Ethyl]Amino]-4-Oxobutyric Acid; 4-((1-Benzyl-2-[(4-Nitrophenyl)Amino]-2-Oxoethyl)Amino)-4-Oxobutanoic Acid. Grades: 95%. CAS No. 2440-62-2. Molecular formula: C19H19N3O6. Mole weight: 385.40. |