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| Product | Description | |
|---|---|---|
| Collagenase | Collagenase. Categories: collagenase; ft-0624030. |  CA, FL & NJ |
| Collagenase AF-1 GMP Grade | Collagenase AF-1 GMP Grade, often in combination with Neutral Protease AF GMP Grade, is suitable for the dissociation of sensitive cells from several tissues, such as pancreas, liver and dental pulp. It has been shown to be highly effective for the isolation of islets of Langerhans from human pancreas intended for transplantation. Applications: Collagenase af-1 gmp grade is suitable for cell isolation from several tissue types intended for clinical applications. it is often used in combination with neutral protease af gmp grade. Group: Enzymes. Synonyms: Collagenase AF-1; Collagenase; Collagenase AF-1 GMP; Collagenase GMP. Enzyme Commission Number: EC 3.4.24.3. CAS No. 9001-12-1. Collagenase. Activity: ≥ 3.00 U/mg. Storage: 2 to 8 °C. Form: Lyophilized powder. Source: Clostridium histolyticum. Collagenase AF-1; Collagenase; Collagenase AF-1 GMP; Collagenase GMP. Cat No: NATE-1919. |  |
| Collagenase-chromophore-substrate,component a | Heterocyclic Organic Compound. Alternative Names: Collagenase Chromophore-Substrate, 4-Phenylazobenzyloxycarbonyl-Pro-Leu-Gly-Pro-D-Arg-OH dihydrate, 118081-33-7. CAS No. 118081-33-7. Molecular formula: C38H52N10O8·2H2O. Mole weight: 812.91. Purity: 0.96. IUPACName: (2R) -5- (diaminomethylideneamino) -2- [ [ (2S) -1- [2- [ [ (2S) -4-methyl-2- [ [ (2S) -1- [ (4-phenyldiazenylphenyl) methoxycarbonyl] pyrrolidine-2-carbonyl] amino] pentanoyl] amino] acetyl] pyrrolidine-2-carbonyl] amino] pentanoic acid;dihydrate. Canonical SMILES: CC (C)CC (C (=O)NCC (=O)N1CCCC1C (=O)NC (CCCN=C (N)N)C (=O)O)NC (=O)C2CCCN2C (=O)OCC3=CC=C (C=C3)N=NC4=CC=CC=C4. O. O. Catalog: ACM118081337. |  |
| Collagenase Chromophore Substrate Test Substance | Collagenase Chromophore Substrate Test Substance is an enzyme substrate. Synonyms: 4-phenylazobenzyl-oxycarbonyl-l-prolyl-l-leucine; 1-[ ({4-[ (E) -Phenyldiazenyl]phenyl}methoxy) carbonyl]-L-prolyl-L-leucine. CAS No. 98640-71-2. Molecular formula: C25H30N4O5. Mole weight: 466.53. |  |
| Collagenase (food grade) | Collagenase is an enzyme complex to hydrolyzed gelatin and collagen, mainly composed by endo-proteases, exo-protease and flavor enzymes. Group: Enzymes. Synonyms: Endo-protease; Exo-protease; flavor enzyme; Collagenase. Collagenase. Activity: >100,000 u/g. Appearance: White or yellowish, odorless, powder. Endo-protease; Exo-protease; flavor enzyme; Collagenase. Cat No: NATE-1594. | |
| Collagenase from Clostridium histolyticum | 100mg Pack Size. Group: Analytical Reagents, Biochemicals, Building Blocks, Catalysts, Diagnostic Raw Materials, Organics. Formula: N/A. CAS No. 9001-12-1. Prepack ID 90029169-100mg. See USA prepack pricing. |  |
| Collagenase I, from Clostridium histolyticum | Collagenases are enzymes that break the peptide bonds in collagen. Collagenases are derived from the Clostridium histolyticum. Collagenases (Type I) are proteolytic enzymes that break peptide bonds in collagen and can be used for tissue digestion and dissociation. Uses: Scientific research. Group: Signaling pathways. CAS No. 9001-12-1. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-O0004. |  |
| Collagenase inhibitor i | Heterocyclic Organic Compound. Alternative Names: Z-PRO-D-LEU-D-ALA-NHOH;Z-PDLDA-NHOH;COLLAGENASE INHIBITOR I. CAS No. 123984-15-6. Molecular formula: C22H32N4O6. Mole weight: 448.51. Appearance: White solid. Catalog: ACM123984156. | |
| Collagenase IV, Clostridium histolytica | Collagenase, Type IV (EC 3.4.24.3) is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type IV degrades type IV collagen and type VII collagen, the main components of the basement membrane, and can also decompose basement matrix and elastin. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Collagenase, Type IV. CAS No. 9001-12-1. Pack Sizes: 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-E70005D. | |
| Collagenase NB 6 from Clostridium histolyticum (GMP Grade) | Collagenases from Clostridium histolyticum are proteolytic enzymes that cleave peptide bonds in the triple helical collagen molecule of human or animal tissue in situ. For this reason collagenases are widely used for isolation of various cell types by tissue dissociation. Applications: Collagenase nb 6 gmp grade is suitable for cell isolation from various tissue types intended for clinical applications. if a research or sterile product is required, collagenase nb 4 standard grade or collagenase nb 5 sterile grade, respectively, are recommended. both products have comparable enzymatic activities to collagenase nb 6 gmp grade. Group: Enzymes. Synonyms: Collagenase NB 6; Collagenase NB; Collagenase. Enzyme Commission Number: EC 3.4.24.3. CAS No. 9001-12-1. Collagenase. Mole weight: 70 000 - 120 000 (collagenases). Activity: ≥ 0.100 U/mg. Storage: 2 to 8 °C. Form: Lyophilized powder. Source: Clostridium histolyticum. Collagenase NB 6; Collagenase NB; Collagenase. Cat No: NATE-1918. | |
| Collagenase/Neutral Protease Blend (GMP Grade) | NATE-1917 is an avian and mammalian tissue-free Collagenase and neutral protease enzyme blend produced under GMP quality conditions. Applications: Nate-1917 is specifically designed for stem cell isolation from human and other adipose tissue with following advantages:o a single, sterile, ready-to-use vial containing both collagenase and neutral protease can digest up to 280g of adipose tissue with best-in-class gmp quality and shelf life of up to 72 months.o currently included in ide applications approved by the u.s. fda for alopecia, chronic heart failure, hamstring injuries, osteoarthritis of the knee, and hand manifestations of scleroderma.o research protocols are a...sociation of nucleated cells from adipose tissue.o produced using avian and mammalian tissue-free raw materials, aseptic processes and sterile filtration under gmp guidelines to assure the lowest levels of impurities and stringent quality standards. Group: Enzymes. Synonyms: Collagenase/Neutral Protease Blend; GMP, Collagenase/Neutral Protease Blend; Collagenase; Neutral Protease; GMP. Collagenase. Stability: 48 months at -15 to -25° C. Appearance: White lyophilizate. Source: Clostridium histolyticum/Bacillus polymyxa. Collagenase/Neutral Protease Blend; GMP, Collagenase/Neutral Protease Blend; Collagenase; Neutral Protease; GMP. Pack: 1 vial, 35 mg. Cat No: NATE-1917. | |
| Collagenase Substrate | Synonyms: Z-Gly-Pro-Gly-Gly-Pro-Ala-OH. Grades: 95%. CAS No. 13075-38-2. Molecular formula: C27H36N6O9. Mole weight: 588.61. | |
| Collagenase, Type II | Collagenase, Type II is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type II breaksdown collagens1, 3, 5, 7, 8, 10, fibronectin, gelatin, aggrecann [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 9001-12-1. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-E70005B. | |
| Collagenase, Type V | Collagenase, Type V is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type V breaksdown collagens1, 3, 5, 7, 8, 10, fibronectin, gelatin, aggrecann [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 9001-12-1. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-E70005E. | |
| interstitial collagenase | The enzyme takes its name from substrates of the interstitial collagen group - types I, II and III, all of which are cleaved in the helical domain. However, α-macroglobulins are cleaved much more rapidly. The enzyme is widely distributed in vertebrate animals. Type example of peptidase family M10. Group: Enzymes. Synonyms: vertebrate collagenase; matrix metalloproteinase 1. Enzyme Commission Number: EC 3.4.24.7. CAS No. 9001-12-1. Matrix Metalloproteinase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4353; interstitial collagenase; EC 3.4.24.7; 9001-12-1; vertebrate collagenase; matrix metalloproteinase 1. Cat No: EXWM-4353. | |
| microbial collagenase | Six species of metalloendopeptidase acting on native collagen can be isolated from the medium of Clostridium histolyticum. Class I has forms α (68 kDa), β (115 kDa) and γ (79 kDa); class II has Δ (100 kDa), ε (110 kDa) and ζ (125 kDa). The two classes are immunologically crossreactive, but have significantly different sequences, and different specificities such that their actions on collagen are complementary. The enzymes also act as peptidyl-tripeptidases. Variants of the enzyme have been purified from Bacillus cereus, Empedobacter collagenolyticum, Pseudomonas marinoglutinosa, and species of Vibrio, Vibrio B-30 (ATCC 21250) and V. alginolyticu...ase-8; matirx metalloproteinase-18; interstitial collagenase. Enzyme Commission Number: EC 3.4.24.3. CAS No. 9001-12-1. Collagenase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4311; microbial collagenase; EC 3.4.24.3; 9001-12-1; Clostridium histolyticum collagenase; clostridiopeptidase A; collagenase A; collagenase I; Achromobacter iophagus collagenase; collagenase; aspergillopeptidase C; nucleolysin; azocollase; metallocollagenase; soycollagestin; Clostridium histolyticum proteinase A; clostridiopeptidase II; MMP-8; clostridiopeptidase I; collagen peptidase; collagen protease; collagenase MM | |
| Native Clostridium histolyticum Collagenase | Collagenases are endopeptidases that digest native collagen in the triple helix region. Collagens are the major fibrous component of animal extracellular connective tissue. Bacterial collagenases differ from vertebrate collagenases in that they exhibit broader substrate specificity (Peterkofsky 1982, Birkedal-Hansen 1987). Unlike animal collagenases that split collagen in its native triple-helical conformation (Woolley et al. 1975, Gross et al. 1974), bacterial collagenase is unique because it can degrade both water-insoluble native collagens and water-soluble denatured ones. It can attack almost all collagen types, and is able to make multiple cleavages within triple h...ations needing to avoid introduction of animal derived pathogens into bioprocessing procedures. Group: Enzymes. Synonyms: EC 3.4.24.3; Collagenase; Clostridiopeptidase A; Clostridium histolyticum collagenase; collagenase A; collagenase I; Achromobacter iophagus collagenase; aspergillopeptidase C; nucleolysin; Collagenase, Type 1; Collagenase, Type 2; Collagenase, Type 3; Collagenase, Type 4; Collagenase, Type 5. Enzyme Commission Number: EC 3.4.24.3. CAS No. 9001-12-1. Collagenase. Mole weight: 68 to 130 kDa. Activity: Type 1 > 125 units per mg; Type 2 > 125 units per mg; Type 3 > 100 units per mg; Type 4 > 160 units per mg; Type 5 > 450 units per mg. Stability: This pro | |
| neutrophil collagenase | Similar to interstitial collagenase in specificity, but the product of a different gene and highly glycosylated. Stored in the specific granules of neutrophil leukocytes. In peptidase family M10 (interstitial collagenase family). Formerly included in EC 3.4.24.7. Group: Enzymes. Synonyms: matrix metalloproteinase 8; PMNL collagenase; MMP-8. Enzyme Commission Number: EC 3.4.24.34. CAS No. 9001-12-1. Matrix Metalloproteinase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4316; neutrophil collagenase; EC 3.4.24.34; 9001-12-1; matrix metalloproteinase 8; PMNL collagenase; MMP-8. Cat No: EXWM-4316. | |
| (2E) -6-[[ (1, 1-Dimethylethoxy) carbonyl]amino]-2-hexenoic Acid | (2E) -6-[[ (1, 1-Dimethylethoxy) carbonyl]amino]-2-hexenoic Acid is an intermediate in the synthesis of (E)-6-Amino-2-hexenoic Acid, used in the preparation of anti-collagenase active agent. Group: Biochemicals. Alternative Names: (E) -6-[[ (1, 1-Dimethylethoxy) carbonyl]amino]-2-hexenoic Acid. Grades: Highly Purified. CAS No. 145119-17-1. Pack Sizes: 250mg. Molecular Formula: C??H??NO?, Molecular Weight: 229.27. US Biological Life Sciences. |  Worldwide |
| (2E) -6-[[ (1, 1-Dimethylethoxy) carbonyl]amino]-2-hexenoic Acid Ethyl Ester | (2E) -6-[[ (1, 1-Dimethylethoxy) carbonyl]amino]-2-hexenoic Acid Ethyl Ester is an intermediate in the synthesis of (E)-6-Amino-2-hexenoic Acid (A609990), used in the preparation of anti-collagenase active agent. Group: Biochemicals. Grades: Highly Purified. CAS No. 1008751-73-2. Pack Sizes: 50mg, 250mg. Molecular Formula: C13H23NO4. US Biological Life Sciences. | Worldwide |
| 2-Hydroxy-1-pyrrolidinecarboxylic Acid 1,1-Dimethylethyl Ester | 2-Hydroxy-1-pyrrolidinecarboxylic Acid 1,1-Dimethylethyl Ester is an intermediate in the synthesis of (E)-6-Amino-2-hexenoic Acid (A609990), used in the preparation of anti-collagenase active agent. Group: Biochemicals. Grades: Highly Purified. CAS No. 84766-91-6. Pack Sizes: 500mg, 5g. Molecular Formula: C9H17NO3. US Biological Life Sciences. | Worldwide |
| 3,?5,?6,?7,?8,?3',?4'-?Heptemthoxyflavone | 3,5,6,7,8,3',4'-Heptemthoxyflavone, a flavonoid from satsuma peel, is an orally available CREB activator with anti-tumor and anti-neuroinflammatory activity. 3,5,6,7,8,3',4'-Heptemthoxyflavone inhibits collagenase activity and increases the content of type I procollagen in human dermal fibroblast neoblast (HDFn) cells. 3,5,6,7,8,3',4'-Heptemthoxyflavone induces brain-derived neurotrophic factor (BDNF) expression through the cAMP/ERK/CREB signaling pathway and reduces phosphodiesterase activity in C6 glioma [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. CAS No. 1178-24-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N2038. | |
| Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt | It is used as a substrate in a rapid, sensitive, continuous spectrophotometric assay for vertebrate collagenase, gelatinase A, and gelatinase B. Synonyms: Glycine, 1-acetyl-L-prolyl-L-leucylglycyl-2-mercapto-4-methylpentanoyl-L-leucyl-, ethyl ester. CAS No. 98992-65-5. Molecular formula: C31H53N5O8S. Mole weight: 655.85. | |
| (-)-Actinonin (N4-Hydroxy-N1-[(1S)-1[[(2S)-2-(hydroxymethyl)-1-pyrroldinyl]carbonyl]-2-methylpropyl]-2-pentyl-,(2R)-(9CI)) | A potent in vivo inhibitor of collagenase. Group: Biochemicals. Alternative Names: N4-Hydroxy-N1-[(1S)-1[[(2S)-2-(hydroxymethyl)-1-pyrroldinyl]carbonyl]-2-methylpropyl]-2-pentyl-,(2R)-(9CI). Grades: Highly Purified. CAS No. 13434-13-4. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Adenosine (9- β-D-ribofuranosyladenine, Adenine riboside, Adenine-9- β-D-ribofuranoside) | In the extracellular space, ecto-5?-nucleotidase (CD73) dephosphorylates adenosine triphosphate (ATP) to produce adenosine. Adenosine has four receptors namely A1R, A2AR A2BR and A3R. Adenosine plays a key role in the osteogenic differentiation. A1R induces osteoclast differentiation and A2AR induces osteoblast differentiation. Adenosine has been used: as a supplement in embryonic type culture medium for in vitro osteogenic differentiation for evaluation of its effect on cell survival by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT assay) and cell proliferation by 3H-thymidine incorporation assay in multi drug resistant glioblastoma stem-like cells (GSCs), and as a standard in high performance liquid chromatography (HPLC). as a constituent in collagenase solution for the collagenase digestion of mice fat tissue. Group: Biochemicals. Alternative Names: 9- β-D-Ribofuranosyl-9H-purin-6-amine; 9- β-D-Ribofuranosyladenine; Adenine Riboside; Adenocard; Adenocor; Adenogesic; Adenoscan; Adrekar; Boniton; D-Adenosine; 1-(6-Amino-9H-purin-9-yl)-1-deoxy- β-D-ribofuranose; Myocol; NSC 7652. Grades: Molecular Biology Grade. CAS No. 58-61-7. Pack Sizes: 100g, 500g. Molecular Formula: C10H13N5O4, Molecular Weight: 267.25. US Biological Life Sciences. | Worldwide |
| Aranciamycin | Antibiotic. Similar to steffimycin. Active against Gram-positive bacteria. Clostridium histolyticum collagenase inhibitor. Antitumor compound. Group: Biochemicals. Grades: Highly Purified. CAS No. 72389-06-1. Pack Sizes: 500ug, 1mg. US Biological Life Sciences. | Worldwide |
| Aureoquinone | Aureoquinone is produced by the strain of Aureobasidium sp. The IC50 (μg/mL) for inhibiting the activity of protease, including trypsin, papain, thermophilic protease, collagenase and pound-protease are 11.4?14.5?17.8?7.1?and 8.7 respectively. Synonyms: 2,5,7,8-tetrahydroxy-3,6-dimethylnaphthalene-1,4-dione. Molecular formula: C12H10O6. Mole weight: 250.20. | |
| CL 82,198 | CL 82,198 is a selective inhibitor of human collagenase-3, also known as matrix metalloproteinase-13 (MMP-13). It doesn't have effect against MMP-1, MMP-9 or TNF-α converting enzyme. CL 82,198 is also used to evaluate the role of MMP-13 in diverse processes, including cancer cell migration, acute lung injury, and joint degeneration associated with osteoarthritis. Synonyms: CL-82198; N-[4-(4-Morpholinyl)butyl]-2-benzofurancarboxamide. Grades: ≥95%. CAS No. 307002-71-7. Molecular formula: C17H22N2O3. Mole weight: 302.4. | |
| Coptisine Chloride | Coptisine is an alkaloid found in Chinese goldthread (Coptis chinensis). A bacterial collagenase inhibitor. Group: Biochemicals. Alternative Names: 6, 7-Dihydrobis[1, 3]benzodioxolo[5, 6-a:4', 5'-g]quinolizinium Chloride. Grades: Highly Purified. CAS No. 6020-18-4. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Ecamsule | Ecamsule is a broad-spectrum UVA filter that can be used in sunscreen product. Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression. Ecamsule has the potential for the research of polymorphous light eruption (PMLE) [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 92761-26-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16182. | |
| envelysin | A glycoprotein from various members of the class Echinoidea. Extracellular enzyme requiring Ca2+. In peptidase family M10 (interstitial collagenase family). Group: Enzymes. Synonyms: sea-urchin-hatching proteinase; hatching enzyme; chorionase; chorion-digesting proteinase; chymostrypsin; sea urchin embryo hatching enzyme. Enzyme Commission Number: EC 3.4.24.12. CAS No. 50812-13-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4293; envelysin; EC 3.4.24.12; 50812-13-0; sea-urchin-hatching proteinase; hatching enzyme; chorionase; chorion-digesting proteinase; chymostrypsin; sea urchin embryo hatching enzyme. Cat No: EXWM-4293. | |
| FALGPA | Falgpa is a type of synthetic compound that has been used in laboratory experiments for various purposes since its discovery in the 1990s. It is a derivative of the naturally occurring chemical, phenylalanine, and has been found to have a variety of biochemical and physiological effects on living organisms. Synonyms: 2-furanacryloyl-leucyl-glycyl-prolyl-alanine; FA-LEU-GLY-PRO-ALA-OH; FALGPA; COLLAGENASE SUBSTRATE II; N-(3-[2-FURYL]ACRYLOYL)-LEU-GLY-PRO-ALA; N-[3-(2-FURYL)ACRYLOYL]-L-LEUCYL-GLYCYL-L-PROLYL-L-ALANINE; clostridiopeptidase; N-(3-(2-FURYL)ACRYLOYL)-L-LEUCYL-GLY. Grades: >95% by HPLC. CAS No. 78832-65-2. Molecular formula: C23H32N4O7. Mole weight: 476.52. | |
| fragilysin | Thought to be a cause of diarrhoea in animals and humans. Hydrolyses extracellular matrix proteins, and disrupts tight junctions of intestinal epithelial cells. Also degrades intracellular, cytoskeletal proteins actin, myosin and others. In peptidase family M10 (interstitial collagenase family). Group: Enzymes. Synonyms: Bacteroides fragilis (entero)toxin. Enzyme Commission Number: EC 3.4.24.74. CAS No. 188596-63-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4358; fragilysin; EC 3.4.24.74; 188596-63-6; Bacteroides fragilis (entero)toxin. Cat No: EXWM-4358. | |
| Freselestat | Freselestat is a high affinity and selective human neutrophil elastase 1 (HNE1) inhibitor (Ki = 12 nM) with >100-fold less activity at other related proteases including trypsin, pancreatic elastase, collagenase and murine macrophage elastase. Freselestat can be used as treatment for neutrophil-predominant inflammatory lung diseases. Synonyms: 2-(5-amino-6-oxo-2-phenylpyrimidin-1-yl)-N-[1-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-3-methyl-1-oxobutan-2-yl]acetamide; ONO6818; ONO 6818; ONO-6818. Grades: 95%. CAS No. 208848-19-5. Molecular formula: C23H28N6O4. Mole weight: 452.51. | |
| Funalenone | Funalenone is a phenalene compound originally isolated from A. niger. It inhibits HIV-1 integrase and type I collagenase. Funalenone is also a selective inhibitor of matrix metalloproteinase-1 (MMP-1; IC50 = 170 μM). Synonyms: 8-deoxyxanthoherquein; 3,4,7,9-tetrahydroxy-2-methoxy-6-methyl-1H-phenalen-1-one. Grades: ≥95%. CAS No. 259728-61-5. Molecular formula: C15H12O6. Mole weight: 288.25. | |
| Funalenone (3,4,7,9-Tetrahydroxy-6-methyl-1H-phenalen-1-one) | Matrix metalloproteinase-1 (MMP-1; Type I collagenase) inhibitor. HIV-1 integrase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 259728-61-5. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| gelatinase A | A secreted endopeptidase in peptidase family M10 (interstitial collagenase family), but possessing an additional fibronectin-like domain. Group: Enzymes. Synonyms: 72-kDa gelatinase; matrix metalloproteinase 2; type IV collagenase (ambiguous); 3/4 collagenase (obsolete); matrix metalloproteinase 5 (obsolete); 72 kDa gelatinase type A; collagenase IV (ambiguous); collagenase type IV (ambiguous); MMP 2; type IV collagen metalloproteinase (ambiguous); type IV collagenase/gelatinase (ambiguous). Enzyme Commission Number: EC 3.4.24.24. CAS No. 146480-35-5. Matrix Metalloproteinase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4305; gelatinase A; EC 3.4.24.24; 146480-35-5; 72-kDa gelatinase; matrix metalloproteinase 2; type IV collagenase (ambiguous); 3/4 collagenase (obsolete); matrix metalloproteinase 5 (obsolete); 72 kDa gelatinase type A; collagenase IV (ambiguous); collagenase type IV (ambiguous); MMP 2; type IV collagen metalloproteinase (ambiguous); type IV collagenase/gelatinase (ambiguous). Cat No: EXWM-4305. | |
| gelatinase B | Similar to gelatinase A, but possesses a further domain. In peptidase family M10 (interstitial collagenase family). Group: Enzymes. Synonyms: 92-kDa gelatinase; matrix metalloproteinase 9; type V collagenase; 92-kDa type IV collagenase; macrophage gelatinase; 95 kDa type IV collagenase/gelatinase; collagenase IV (ambiguous); collagenase type IV (ambiguous); gelatinase MMP 9; MMP 9; type IV collagen metalloproteinase (ambiguous). Enzyme Commission Number: EC 3.4.24.35. CAS No. 146480-36-6. Matrix Metalloproteinase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4317; gelatinase B; EC 3.4.24.35; 146480-36-6; 92-kDa gelatinase; matrix metalloproteinase 9; type V collagenase; 92-kDa type IV collagenase; macrophage gelatinase; 95 kDa type IV collagenase/gelatinase; collagenase IV (ambiguous); collagenase type IV (ambiguous); gelatinase MMP 9; MMP 9; type IV collagen metalloproteinase (ambiguous). Cat No: EXWM-4317. | |
| hypodermin C | From the larva of a warble fly, Hypoderma lineatum. Little action on small molecule substrates of trypsin, chymotrypsin, elastase or microbial collagenases. In peptidase family S1 (trypsin family). Group: Enzymes. Synonyms: Hypoderma collagenase. Enzyme Commission Number: EC 3.4.21.49. CAS No. 122191-36-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4142; hypodermin C; EC 3.4.21.49; 122191-36-0; Hypoderma collagenase. Cat No: EXWM-4142. | |
| K-1115A | It is produced by the strain of Streptomyces griseorubiginosus Mer-K1115. K1115A inhibited the direct binding of activator protein-1 (AP-1) to AP-1 oligonucleotide (IC50 = 100 microM), and the production of collagenase in IL-1 alpha-stimulated rat synovial cells (IC50 = 60 microM). Synonyms: K1115 A; 2-Anthracenecarboxylic acid, 9,10-dihydro-3,8-dihydroxy-9,10-dioxo-1-propyl-. CAS No. 208525-17-1. Molecular formula: C18H14O6. Mole weight: 326.30. | |
| K1115 B1 | It is a co-produced compound of K-1115A produced by the strain of Streptomyces griseorubiginosus Mer-K1115. K1115 B1 inhibited the direct binding of activator protein-1 (AP-1) to AP-1 oligonucleotide, and the production of collagenase in IL-1 alpha-stimulated rat synovial cells. Synonyms: XR-573. Molecular formula: C22H24O8. Mole weight: 416.42. | |
| K1115 B2 | It is a co-produced compound of K-1115A produced by the strain of Streptomyces griseorubiginosus Mer-K1115. K1115 B2 inhibited the direct binding of activator protein-1 (AP-1) to AP-1 oligonucleotide, and the production of collagenase in IL-1 alpha-stimulated rat synovial cells. Molecular formula: C23H26O9. Mole weight: 446.45. | |
| Laccaridione A | It is produced by the strain of Laccaria amethystea. It can inhibit the activity of antiserine protease. It inhibits trypsin, papain, thermophilic protease, collagenase and zinc protease with IC50 (μg/mL) of 14.7, 2.5, 18.8, 7.2 and 18.2, respectively. Synonyms: 10-hydroxy-1,7-dimethoxy-3-[(2E)-4-methylhex-2-en-2-yl]-1H-benzo[g]isochromene-8,9-dione; 1H-Naphtho(2,3-C)pyran-8,9-dione, 3-((1E)-1,3-dimethyl-1-penten-1-yl)-10-hydroxy-1,7-dimethoxy-. CAS No. 320369-80-0. Molecular formula: C22H24O6. Mole weight: 384.42. | |
| Laccaridione B | It is produced by the strain of Laccaria amethystea. It can inhibit the activity of antiserine protease. It inhibits trypsin, papain, thermophilic protease, collagenase and zinc protease with IC50 (μg/mL) of 10.9, 5.1, 8.4, 5.7 and 3.0, respectively. It also has a strong anti-proliferative activity against L-929, K-562 and HeLa cells with IC50 (μg/mL) of 2.4, 1.8 and 13.9, respectively. Synonyms: 1-ethoxy-10-hydroxy-7-methoxy-3-[(2E)-4-methylhex-2-en-2-yl]-1H-benzo[g]isochromene-8,9-dione; 1H-Naphtho[2,3-c]pyran-8,9-dione, 3-[(1E)-1,3-dimethyl-1-pentenyl]-1-ethoxy-10-hydroxy-7-methoxy-. CAS No. 320369-81-1. Molecular formula: C23H26O6. Mole weight: 398.45. | |
| L-Alanine benzyl ester hydrochloride | A benzoxazine derivative used as an additive in the microemulsion formulation for topical applications of acyclovir. A reagent in the preparation of collagenase inhibitors. Synonyms: L-Ala-OBzl HCl; L-Alanine benzyl ester hydrochloride. Grades: ≥ 98% (HPLC). CAS No. 5557-83-5. Molecular formula: C10H13NO2·HCl. Mole weight: 215.90. | |
| L-Alanine Benzyl Ester Hydrochloride | A benzoxazine derivative used as an additive in the microemulsion formulation for topical applications of acyclovir. A reagent in the preparation of collagenase inhibitors. Group: Biochemicals. Alternative Names: L-Alanine Phenylmethyl Ester Hydrochloride; (S)-Benzyl 2-aminopropanoate Hydrochloride; Benzyl L-Alaninate Hydrochloride; NSC 523831. Grades: Highly Purified. CAS No. 5557-83-5. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
| macrophage elastase | This enzyme is synthesized as a proenzyme of 53 kDa that is converted to an active form of 22 kDa. cDNA sequences have been obtained for the mouse and human enzymes. In peptidase family M10 (interstitial collagenase family). Group: Enzymes. Synonyms: metalloelastase; human macrophage metalloelastase (HME). Enzyme Commission Number: EC 3.4.24.65. CAS No. 9004-6-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4348; macrophage elastase; EC 3.4.24.65; 9004-06-2; metalloelastase; human macrophage metalloelastase (HME). Cat No: EXWM-4348. | |
| Matlystatin A | It is produced by the strain of Actinomadura atramentaria. It's a Type V collagenase inhibitor. It can inhibit type IV collagenase and type I collagenase with ID50 (μmol/L) of 0.3 and 1.2, respectively. It has anti-gram-positive bacteria effect. Synonyms: N-Acetyl-S-(4-(((hexahydro-2-(2-(2-(hydroxyamino)-2-oxoethyl)-1-oxoheptyl)-3-pyridazinyl)carbonyl)amino)-5-methyl-3-oxoheptyl)-L-cysteine; N-acetyl-S- (4- (2- (2- (2- (hydroxyamino) -2-oxoethyl) heptanoyl) hexahydropyridazine-3-carboxamido) -5-methyl-3-oxoheptyl) -L-cysteine. CAS No. 140626-94-4. Molecular formula: C27H47N5O8S. Mole weight: 601.76. | |
| Matlystatin B | It is produced by the strain of Actinomadura atramentaria. It's a Type V collagenase inhibitor. It can inhibit type IV collagenase and type I collagenase with ID50 (μmol/L) of 1.43 and 1.2, respectively. It has anti-gram-positive bacteria effect. Synonyms: 1(2H)-Pyridazinebutanamide, tetrahydro-N-hydroxy-6-[[[2-methyl-1-(1-oxopropyl)butyl]amino]carbonyl]-g-oxo-b-pentyl-, [6S-[1(S*),6R*(1R*,2R*)]]-; Matlystatin B1. CAS No. 140923-32-6. Molecular formula: C22H40N4O5. Mole weight: 440.58. | |
| Matlystatin D | It is produced by the strain of Actinomadura atramentaria. It's a Type V collagenase inhibitor. It can inhibit type IV collagenase and type I collagenase with ID50 (μmol/L) of 3.64 and 28, respectively. Synonyms: Matlystatin D1; Pyrazolo(1,2-a)pyridazin-4-ium,8-carboxy-1-(1-(((hexahydro-2-(2-(2-(hydroyamino)-2-oxoethyl)-1-oxoheptyl)-3-pyridazinyl)carbonyl)amino)-2-methylbutyl)-5,6,7,8-tetrahydro-,hydroxide,inner salt; [(3-{6-[{[1-(8-Carboxy-5,6,7,8-tetrahydropyrazolo[1,2-a]pyridazin-9-ium-1-yl)-2-methylbutyl]imino}(hydroxy)methyl]-1,2-diazinane-1-carbonyl}-1-hydroxyoctylidene)amino]oxidanide. CAS No. 140638-25-1. Molecular formula: C27H44N6O6. Mole weight: 548.68. | |
| Matlystatin E | It is produced by the strain of Actinomadura atramentaria. It's a Type V collagenase inhibitor. It can inhibit type IV collagenase and type I collagenase with ID50 (μmol/L) of 19.3 and 59, respectively. Synonyms: Matlystatin E1; Pyrazolo(1,2-a)pyridazin-4-ium,8-carboxy-1-(1-(((hexahydro-2-(2-(2-(hydroxyamino)-2-oxoethyl)-1-oxohexyl)-3-pyridazinyl)carbonyl)amino)-2-methylbutyl)-5,6,7,8-tetrahydro-,hydroxide,inner salt; [(3-{6-[{[1-(8-Carboxy-5,6,7,8-tetrahydropyrazolo[1,2-a]pyridazin-9-ium-1-yl)-2-methylbutyl]imino}(hydroxy)methyl]-1,2-diazinane-1-carbonyl}-1-hydroxyheptylidene)amino]oxidanide. CAS No. 140638-26-2. Molecular formula: C26H42N6O6. Mole weight: 534.65. | |
| Matlystatin F | It is produced by the strain of Actinomadura atramentaria. It's a Type V collagenase inhibitor. It can inhibit type IV collagenase and type I collagenase with ID50 (μmol/L) of 1.82 and 5.1, respectively. Synonyms: Matlystatin F1; Pyrazolo(1,2-a)pyridazin-4-ium,5-carboxy-1-(1-(((hexahydro-2-(2-(2-(hydroyamino)-2-oxoethyl)-1-oxoheptyl)-3-pyridazinyl)carbonyl)amino)-2-methylbutyl)-5,6,7,8-tetrahydro-,hydroxide,inner salt; [(3-{6-[{[1-(5-Carboxy-5,6,7,8-tetrahydropyrazolo[1,2-a]pyridazin-9-ium-1-yl)-2-methylbutyl]imino}(hydroxy)methyl]-1,2-diazinane-1-carbonyl}-1-hydroxyoctylidene)amino]oxidanide. CAS No. 140667-42-1. Molecular formula: C27H44N6O6. Mole weight: 548.68. | |
| matrilysin | Found in rat uterus; at 19 kDa, the smallest member of peptidase family M10 (interstitial collagenase family). Similar in specificity to stromelysin, but more active on azocoll. Group: Enzymes. Synonyms: matrin; uterine metalloendopeptidase; matrix metalloproteinase 7; putative (or punctuated) metalloproteinase-1; matrix metalloproteinase pump 1; MMP 7; PUMP-1 proteinase; PUMP; metalloproteinase pump-1; putative metalloproteinase; MMP. Enzyme Commission Number: EC 3.4.24.23. CAS No. 141256-52-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4304; matrilysin; EC 3.4.24.23; 141256-52-2; matrin; uterine metalloendopeptidase; matrix metalloproteinase 7; putative (or punctuated) metalloproteinase-1; matrix metalloproteinase pump 1; MMP 7; PUMP-1 proteinase; PUMP; metalloproteinase pump-1; putative metalloproteinase; MMP. Cat No: EXWM-4304. | |
| Matrix Metalloproteinase-13 (HisoTag) from Human, Recombinant | Matrix metalloproteinases are members of a unique family of proteolytic enzymes that have a zinc ion at their active sites and can degrade collagens, elastin and other components of the extracellular matrix (ECM). These enzymes are present in normal healthy individuals and have been shown to have an important role in processes such as wound healing, pregnancy, and bone resorption. However, overexpression and activation of MMPs have been linked with a range of pathological processes and disease states involved in the breakdown and remodeling of the ECM. Such diseases include tumor invasion and metastasis, rheumatoid arthritis, periodontal disease and vascular pr..., a ca2+- and zn2+- binding catalytic domain, a hinge region, and a c-terminal hemopexin domain. hydrolyzes collagen type ii 5-6 times faster than collagens type i and iii. exhibits high activity towards gelatin and degrades α1-antichymotrypsin and plasminogen activator inhibitor-2. Group: Enzymes. Synonyms: Collagenase-3; Matrix metallopeptidase 13; MMP13; CLG3; MANDP1; MMP-13. Purity: >90% by SDS-PAGE. Matrix Metalloproteinase. Mole weight: 60 kDa. Activity: >50 mU/mg protein. Storage: < -70°C; Avoid freeze/thaw. Form: Liquid. Source: S. frugiperda. Species: Human. Collagenase-3; Matrix metallopeptidase 13; MMP13; CLG3; MANDP1; MMP-13. Cat No: NATE-0859. | |
| Matrix Metalloproteinase-1 from Human, Recombinant | Matrix metalloproteinases are members of a unique family of proteolytic enzymes that have a zinc ion at their active sites and can degrade collagens, elastin and other components of the extracellular matrix (ECM). These enzymes are present in normal healthy individuals and have been shown to have an important role in processes such as wound healing, pregnancy, and bone resorption. However, overexpression and activation of MMPs have been linked with a range of pathological processes and disease states involved in the breakdown and remodeling of the ECM. Such diseases include tumor invasion and metastasis, rheumatoid arthritis, periodontal disease and vascular processe...may also undergo autocatalysis to yield a 27 kda/22 kda active enzyme. expressed by a large number of cell types. cleaves fibrillar type i collagen. must be activated just prior to use. Group: Enzymes. Synonyms: Matrix Metalloproteinase 1; Human Interstitial Collagenase; Collagenase-1; EC 3.4.24.7; vertebrate collagenase. Enzyme Commission Number: EC 3.4.24.7. CAS No. 9001-12-1. Purity: >90% by SDS-PAGE. Matrix Metalloproteinase. Mole weight: 56 kDa/52 kDa. Activity: >15 mU/mg protein. Storage: < -70°C; Avoid freeze/thaw. Form: Liquid. Source: Human Rheumatoid Synovial Fibroblast. Species: Human. Matrix Metalloproteinase 1; Human Interstitial Collagenase; Collagenase | |
| Matrix Metalloproteinase-2 from Human, Recombinant | Matrix metalloproteinases are members of a unique family of proteolytic enzymes that have a zinc ion at their active sites and can degrade collagens, elastin and other components of the extracellular matrix (ECM). These enzymes are present in normal healthy individuals and have been shown to have an important role in processes such as wound healing, pregnancy, and bone resorption. However, overexpression and activation of MMPs have been linked with a range of pathological processes and disease states involved in the breakdown and remodeling of the ECM. Such diseases include tumor invasion and metastasis, rheumatoid arthritis, periodontal disease and vascular processe... does not interfere with activation. may contain up to 10% timp proteins. during storage, a small portion (less than 10%) of the enzyme may also become activated. Group: Enzymes. Synonyms: 72 kDa Gelatinase; Matrix Metalloproteinase 2; Gelatinase A; EC 3.4.24.24; type IV collagenase; 3/4 collagenase; matrix metalloproteinase 5; 72 kDa gelatinase type A; collagenase IV; collagenase type IV; MMP 2; type IV collagen metalloproteinase; type IV collagenase/gelatinase. Enzyme Commission Number: EC 3.4.24.24. CAS No. 146480-35-5. Purity: >90% by SDS-PAGE. Matrix Metalloproteinase. Mole weight: 72 kDa. Storage: < -70°C; Avoid freeze/thaw. Form: Liquid. Source: CHO Cells. Spe | |
| Matrix Metalloproteinase-3 from Human, Recombinant | Matrix metalloproteinase-3 (MMP-3) also known as stromelysin-1 and transin (EC 3.4.24.17) cleaves a number of substrates including cartilage proteoglycan, collagen types II, III, IV, V and IX, fibronectin, laminin, and can activate MMP 1. MMP-3 is secreted as 57 and 59 kDa proenzymes and can be activated in vitro by organomercurials (e.g., 4 aminophenylmercuric acetate, APMA) and in vivo by proteases via intermediate forms to a 45 kDa active MMP 3 enzyme. Further autolysis to a 28 kDa form can also occur. MMP-3 is thought to play an important role in pathophysiological degradation processes associated with conditions such as rheumatoid arthritis and cancer cell invas...C 3.4.24.17; matrix metalloproteinase 3; proteoglycanase; collagenase activating protein; procollagenase activator; transin; MMP-3; neutral proteoglycanase; stromelysin; collagen-activating protein. Enzyme Commission Number: EC 3.4.24.17. CAS No. 79955-99-0. Purity: >95% by SDS-PAGE. Matrix Metalloproteinase. Mole weight: 57 kDa. Storage: < -70°C; Avoid freeze/thaw. Form: Lyophilized from 100 mM NaCl, 50 mM HEPES, pH 7.3. Species: Human. Stromelysin 1; EC 3.4.24.17; matrix metalloproteinase 3; proteoglycanase; collagenase activating protein; procollagenase activator; transin; MMP-3; neutral proteoglycanase; stromelysin; collagen-activating protein. Cat No: NATE-0861. | |
| Matrix Metalloproteinase-8 from Human, Recombinant | Full-length recombinant human neutrophil pro-collagenase (MMP-8), latent form. Matrix metalloproteinase 8 (MMP-8), or neutrophil collagenase, degrades interstitial collagens, acting preferentially on collagen type I. Increased full-length MMP-8 protein was associated with infiltration into the skin of neutrophils, which are the major cell type that expresses MMP-8. MMP-8 is synthesized and stored in specific granules in neutrophil leukocytes. MMP-8 activity is therefore regulated by factors such as surface-bound ligands (IgG or complement components) that release it through degranulation.Once released and activated through proteolytic or oxidative mechanisms, MMP-8 p...ollagenase activity. Group: Enzymes. Synonyms: Neutrophil collagenase; EC 3.4.24.34; Matrix metalloproteinase-8; MMP-8; PMNL collagenase; PMNL-CL; HNC; CLG1. Enzyme Commission Number: EC 3.4.24.34. CAS No. 9001-12-1. Purity: Greater than 90% as determined by SDS-PAGE. Matrix Metalloproteinase. Mole weight: 75 kDa. Activity: 100 units/ml. Stability: MMP-8 although stable at 4°C for 1 week, should be stored desiccated below -18°C. Please prevent freeze-thaw cycles. Appearance: Sterile Filtered clear solution. Source: E. coli. Species: Human. Neutrophil collagenase; EC 3.4.24.34; Matrix metalloproteinase-8; MMP-8; PMNL collagenase; PMNL-CL; HNC; CLG1. Cat No: NATE-0862. | |
| Matrix Metalloproteinase-9 from Human, Recombinant | Matrix metalloproteinases are members of a unique family of proteolytic enzymes that have a zinc ion at their active sites and can degrade collagens, elastin and other components of the extracellular matrix (ECM). These enzymes are present in normal healthy individuals and have been shown to have an important role in processes such as wound healing, pregnancy, and bone resorption. However, overexpression and activation of MMPs have been linked with a range of pathological processes and disease states involved in the breakdown and remodeling of the ECM. Such diseases include tumor invasion and metastasis, rheumatoid arthritis, periodontal disease and vascular processe...(less than 10%) of the enzyme may also become activated. requires activation prior to use. a simple activation protocol is included. Applications: Immunoblotting (1 ug protein/lane) substrate cleavage assay (1 ug protein/lane) zymography (1 ug protein/lane). Group: Enzymes. Synonyms: Gelatinase B; EC 3.4.24.35; 92-kDa gelatinase; matrix metalloproteinase 9; type V collagenase; 92-kDa type IV collagenase; macrophage gelatinase; 95 kDa type IV collagenase/gelatinase; collagenase IV; collagenase type IV; gelatinase MMP 9; MMP 9; type IV collagen metalloproteinase. Enzyme Commission Number: EC 3.4.24.35. CAS No. 146480-36-6. Purity: >90% by SDS-PAGE. Matrix Metalloprotei | |
| MMP-13 Inhibitor | MMP-13 Inhibitor is a potent and selective inhibitor of matrix metalloproteinase-13 (MMP-13) with IC50 value of 8 nM. Synonyms: Collagenase-3 Inhibitor; Matrix Metalloproteinase-13 Inhibitor; 4,6-Pyrimidinedicarboxamide; N4,N6-Bis(4-fluoro-3-methylbenzyl)pyrimidine-4,6-dicarboxamide. Grades: ≥98%. CAS No. 544678-85-5. Molecular formula: C22H20F2N4O2. Mole weight: 410.4. | |
| MMP-2/MMP-9-IN-1 | MMP-2/MMP-9-IN-1 is a highly selective, orally active and potent type IV collagenase ( MMP-9 and MMP-2 ) inhibitor with IC 50 s of 0.24 and 0.31 μM for MMP-9 and MMP-2, respectively. MMP-2/MMP-9-IN-1 is orally active in animal models of tumor growth and metastasis. MMP-2/MMP-9-IN-1 can be used for the research of cancer [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 193807-58-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116399. | |
| MMP-8 Inhibitor I | MMP-8 Inhibitor I is a selective and cell-permeable inhibitor of matrix metalloproteinase-8 (MMP-8) with IC50 value of 4 nM. MMP-8 is a neutrophil collagenase that cleaves interstitial collagens. MMP-8 is associated with diseases including arthritis, cancer, osteoporosis and arteriosclerosis. Synonyms: Matrix Metalloproteinase-8 Inhibitor I; N-hydroxy-2-(4-methoxyphenyl)sulfonyl-3,4-dihydro-1H-isoquinoline-3-carboxamide. Grades: ≥95%. CAS No. 236403-25-1. Molecular formula: C17H18N2O5S. Mole weight: 362.4. | |
| Native Papaya latex Chymopapain | Chymopapain is a proteolytic enzyme isolated from the latex of papaya (Carica papaya). It is a medication used to treat herniated lower lumbar discs in the spine. Chymopapain injections are normally given under local, Rather than general, anaesthesia. The dose for a single intervertebral disc is 2 to 4 nanokatals, with a maximum dose per patient of 8 nanokatals. The procedure is referred to as chemonucleolysis. Applications: Chymopapain from papaya latex has been used in a study to assess the anthelmintic effect of natural plant cysteine proteinases against the gastrointestinal nematode, heligmosomoides. chymopapain from papaya latex has also been used in a study to investiga...enzyme has been used along with pronase, collagenase, elastase, dnase, and catalase for rabbit lung cells digestion at a concentration of 0.05% in calcium-magnesium-free kreb?s serum substitute. it has also been used for the release of neuroblastoma cells from marrow bound to antibody-coated microspheres. Group: Enzymes. Synonyms: chymopapain A; chymopapain B; chymopapain S; EC 3.4.22.6; 9001-09-6; Chymodiactin. Enzyme Commission Number: EC 3.4.22.6. CAS No. 9001-9-6. Chymopapain. Activity: > 2.0 units/mg protein. Storage: -20°C. Form: lyophilized powder. Source: Papaya latex. chymopapain A; chymopapain B; chymopapain S; EC 3.4.22.6; 9001-09-6; Chymodiactin. Cat No: NATE-0133. | |
| Native Streptomyces griseus Pronase | Pronase is a mixture of several nonspecific endo- and exoproteases that digest proteins down to single amino acids. Applications: Use pronase to completely hydrolyze proteins in research applications. pronase is used for the degradation of proteins during the isolation of dna and rna, such as in the extraction of phage dna or the isolation of plasmid dna. it is not necessary to let pronase self-digest prior to use. it is also used in histochemistry and cell culture for tissue dissociation in conjunction with collagenase and trypsin, and for the production of glycopeptides from purified glycoproteins. Group: Enzymes. Synonyms: non-specific protease. Enzyme Commission Number: EC 3.4.24.4. CAS No. 70851-98-8. Pronase. Activity: ~7.0 units/mg protein (at 40°C with casein as the substrate, pH 7.5, equivalent to approximately 1270 PU/mg or approximately 25 PUK/mg.). Storage: 2-8°C. Form: Lyophilized powder. Source: Streptomyces griseus. non-specific protease; Pronase; EC 3.4.24.4. Cat No: NATE-0997. | |
| Neutral Protease AF GMP Grade | Neutral Protease AF GMP Grade is manufactured according to cGMP guidelines using a production process completely free of animal-based components. In this way the introduction of any potential animal-derived pathogen is excluded. Neutral Protease AF GMP Grade is chromatographically purified and largely free from collagenolytic activity (PZ U) as well as endotoxins. The absence of any animal-derived ingredients and thorough microbial analysis provide the highest possible safety. Applications: Neutral protease af gmp grade is suitable for cell isolation from several tissue types for clinical applications. it is often used in combination with collagenase af-1 gmp grade. Group: Enzymes. Synonyms: Neutral Protease AF GMP Grade; Neutral Protease AF; Neutral Protease; Protease. Enzyme Commission Number: EC 3.4.21.62. CAS No. 9001-92-7. Protease. Mole weight: 34 000. Activity: ≥ 0.50 U/mg. Storage: 2 to 8 °C. Form: Lyophilized powder. Source: Clostridium histolyticum. Neutral Protease AF GMP Grade; Neutral Protease AF; Neutral Protease; Protease. Cat No: NATE-1920. | |
| Paquinimod | Paquinimod, also known as ABR - 215757, belonging to the class of quinoline-3-carboxamide derivatives, is a S100A9 inhibitor. Paquinimod is an immunomodulatory compound that reduces pathology in experimental collagenase-induced osteoarthritis. Synonyms: N,5-diethyl-4-hydroxy-1-methyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide; ABR - 215757; ABR 215757; ABR215757; Paquinimod. Grades: 95%. CAS No. 248282-01-1. Molecular formula: C21H22N2O3. Mole weight: 350.42. | |
| PZ-Peptide | PZ-Peptide is a chromogenic substrate for the assay of collagenase and thimet oligopeptidase (Pz-peptidase, metalloendopeptidase 24.15, collagenase-like peptidase). Synonyms: 4-Phenylazobenzyloxycarbonyl-L-pro-leu-gly-pro-D-arg dihydrate; Pz-Cpz-Pro-Leu-Gly-Pro-Arg. CAS No. 17011-78-8. Molecular formula: C38H52N10O8. Mole weight: 776.88. | |
| Ro 32-3555 | Ro 32-3555 is a selective inhibitor of collagenases over the related human matrix metalloproteinases stromelysin 1, and gelatinases A and B (Ki values of 527, 154 and 59 nM, respectively). It inhibits both the cartilage and bone changes in this mouse model of OA, and thus shows great potential as a treatment of OA in humans. Synonyms: Ro-32-3555; Ro 32 3555; Ro323555; (αR,βR)-β-(Cyclopentylmethyl)-N-hydroxy-γ-oxo-α-[(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)methyl]-1-piperidinebutanamide; Cipemastat; Ro32-3555; 190648-49-8; GFUITADOEPNRML-SJORKVTESA-N; UNII-02HQ4TYQ60; Trocade. Grades: ≥97% by HPLC. CAS No. 190648-49-8. Molecular formula: C22H36N4O5. Mole weight: 436.55. | |
| SC-44463 | SC-44463 is an MMP inhibitor, also a collagenase inhibitor , and HDAC inhibitor. Synonyms: SC44463; SC 44463; (R)-N4-hydroxy-2-isobutyl-N1-((S)-3-(4-methoxyphenyl)-1-(methylamino)-1-oxopropan-2-yl)succinamide. CAS No. 104408-38-0. Molecular formula: C19H29N3O5. Mole weight: 379.45. | |
| serralysin | A 50 kDa extracellular endopeptidase from Pseudomonas aeruginosa, Escherichia freundii, Serratia marcescens and Erwinia chrysanthemi. There is broad specificity in cleavage of the insulin B chain, with some species variations. The pH optimum for digesting various proteins is about 9 - 10. In peptidase family M10 (interstitial collagenase family). Formerly included in EC 3.4.24.4. Group: Enzymes. Synonyms: Pseudomonas aeruginosa alkaline proteinase; Escherichia freundii proteinase; Serratia marcescens extracellular proteinase; Serratia marcescens metalloproteinase; Pseudomonas aeruginosa alk. protease; Serratia marcescens metalloprotease. Enzyme Commission Number: EC 3.4.24.40. CAS No. 70851-98-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4322; serralysin; EC 3.4.24.40; 70851-98-8; Pseudomonas aeruginosa alkaline proteinase; Escherichia freundii proteinase; Serratia marcescens extracellular proteinase; Serratia marcescens metalloproteinase; Pseudomonas aeruginosa alk. protease; Serratia marcescens metalloprotease. Cat No: EXWM-4322. | |
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