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| Product | Description | |
|---|---|---|
| 2,5:3,4-Dianhydro-6-O-2-propenyl-dimethyl acetal-L-talose | 2,5:3,4-Dianhydro-6-O-2-propenyl-dimethyl acetal-L-talose is a multifaceted compound frequently implemented in scientific pursuit, utilized for the estimation of diseases associated with the abnormal metabolism of carbohydrates. Its potency lies in the inhibition of the enzyme α-glucosidase, crucial for carbohydrate catabolism within the body. Diminishing the enzymatic activity results in a significant drop in systemic glucose concentration, thus exhibiting a potential remedy for the management of Type II diabetes and correlated ailments. Synonyms: (1R,2R,4S)-2-(Dimethoxymethyl)-4-(prop-2-enoxymethyl)-3,6-dioxabicyclo[3.1.0]hexane. CAS No. 473796-96-2. Molecular formula: C11H18O5. Mole weight: 230.26. |  |
| 2,6-Dichlorophenolindophenyl acetate | 2,6-Dichlorophenolindophenyl acetate, a prominent biochemical, holds substantial significance in determining ascorbic acid concentrations. Its multidimensional application extends to serving as a redox indicator to detect biomarkers of various viruses and diseases in enzyme-linked immunosorbent assays (ELISA). Synonyms: DIPA; 4-[(2,3-dichloro-4-oxocyclohexa-2,5-dien-1-yl)imino]phenyl acetate. CAS No. 24857-20-3. Molecular formula: C14H9Cl2NO3. Mole weight: 310.13. | |
| 2×HiFi PCR SuperMix | 2×HiFi PCR SuperMix. 2×hifi pcr supermix is a ready-to-use mixture of hifi dna polymerase dna polymerase, dntps and optimized buffer. 2×hifi pcr supermix is optimized for the amplification of genomic dna and pcr supermix ii is optimized for the amplification of λdna, cdna or plasmid dna. the supermix is provided at 2× concentration and can be used at 1× concentration by adding template, primers and h2o. Group: Cloning Enzymes. Purity: 1ml; 5ml. Storage: Store at -20 ?. Cat No: CE-3021. |  |
| 2×HiFi Pfu PCR SuperMix (-dye ) | 2×HiFi Pfu PCR SuperMix (-dye ). 2×hifi pfu pcr supermix (-dye ) is a ready-to-use mixture of hifi pfu dna polymerase, dntps and optimized buffer. the supermix is provided at 2× concentration and used at 1× concentration by adding template, primers and h2o. Group: Cloning Enzymes. Purity: 1ml; 5ml. Storage: Store at -20 ?. Cat No: CE-3002. | |
| 2×KD Plus PCR SuperMix | 2×KD Plus PCR SuperMix. 2×kd plus pcr supermix is a ready-to-use mixture of kd plus dna polymerase, dntps, and optimized buffer. the supermix is provided at 2× concentration and can be used at 1× concentration by adding template, primers and h2o. Group: Cloning Enzymes. Purity: 1ml; 5ml. Storage: Store at -20 ?. Cat No: CE-3020. | |
| 2×Pfu PCR SuperMix (-dye ) | 2×Pfu PCR SuperMix (-dye ). 2×pfu pcr supermix (-dye ) is a ready-to-use mixture of pfu dna polymerase, dntps, and optimized buffer. the supermix is provided at 2× concentration and can be used at 1× concentration by adding template, primers and h2o. Group: Cloning Enzymes. Purity: 1ml; 5ml. Storage: Store at -20 ?. Cat No: CE-3018. | |
| (2R)-2-hydroxy-3-(hydroxymethyl)-3-methyl-N-(3-oxo-4-phenylbutyl)butanamide | (2R)-2-hydroxy-3-(hydroxymethyl)-3-methyl-N-(3-oxo-4-phenylbutyl)butanamide or RR6 is an inhibitor of Vanin which is an enzyme that play a role in the recycling of pantothenic acid (vitamin B5) from pantetheine. Alterations in plasma lipid concentrations in rats caused by RR6 indicates its potential usefulness. Group: Biochemicals. Grades: Highly Purified. CAS No. 1351758-37-6. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C16H23NO4, Molecular Weight: 293.36. US Biological Life Sciences. |  Worldwide |
| (2R)-2-hydroxy-3-(hydroxymethyl)-3-methyl-N-(3-oxo-4-phenylbutyl)butanamide-d5 | (2R)-2-hydroxy-3-(hydroxymethyl)-3-methyl-N-(3-oxo-4-phenylbutyl)butanamide-d5 or RR6 (vanin inhibitor)-d5 is the labelled analogue of 2R)-2-hydroxy-3-(hydroxymethyl)-3-methyl-N-(3-oxo-4-phenylbutyl)butanamide or RR6 (vanin inhibitor) which is an enzyme that play a role in the recycling of pantothenic acid (vitamin B5) from pantetheine. Alterations in plasma lipid concentrations in rats caused by RR6 indicates its potential usefulness. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C16H18D5NO4, Molecular Weight: 298.39. US Biological Life Sciences. | Worldwide |
| 2×Speed Pfu PCR SuperMix (-dye ) | 2×Speed Pfu PCR SuperMix (-dye ). Transstart® fastpfu fly pcr supermix is a ready-to-use mixture of transstart® fastpfu fly dna polymerase, dntps, and optimized buffer. the supermix is provided at 2× concentration and can be used at 1× concentration by adding template, primers and h2o.; transstart® fastpfu fly pcr supermix offers 108-fold fidelity as compared to easytaq® dna polymerase. extension rate is about 2-6 kb/min. pcr products can be directly cloned into peasy®-blunt vectors. amplification of genomic dna fragment up to 15 kb. amplification of plasmid dna fragment up to 20 kb. Group: Cloning Enzymes. Purity: 1ml; 5ml; 15ml. Storage: Store at -20 ?. Cat No: CE-3017. | |
| 2×TA PCR SuperMix | 2×TA PCR SuperMix. 2×ta pcr supermix is a ready-to-use mixture of ta dna polymerase, dntps and optimized buffer. the supermix is provided at 2× concentration and used at 1× concentration by adding template, primers and h2o. efficiency of pcr products with a is equal to taq dna polymerase. it is more suitable for high fidelity ta cloning. Group: Cloning Enzymes. Purity: 1ml; 5ml. Storage: Store at -20 ?. Cat No: CE-3023. | |
| 2×Taq PCR SuperMix | 2×Taq PCR SuperMix. 2×taq pcr supermix is a ready-to-use mixture of taq dna polymerase, dntps and optimized buffer. the supermix is provided at 2×concentration and used at 1× concentration by adding template, primers and h2o. pcr products are not suitable for directly load to page. Group: Cloning Enzymes. Purity: 1ml; 5ml; 15ml. Storage: Store at -20 ?. Cat No: CE-3005. | |
| 2×Taq PCR SuperMix for PAGE(+dye) | 2×Taq PCR SuperMix for PAGE(+dye). 2×taq pcr supermix for page(+dye) is a ready-to-use mixture of dna polymerase for page, dntps and optimized buffer. the supermix for page is provided at 2× concentration and used at 1× concentration by adding template, primers and h2o. Group: Cloning Enzymes. Purity: 1ml; 5ml; 15ml. Storage: Store at -20 ?. Cat No: CE-3006. | |
| 3-Deoxy-3-fluoro-D-glucitol | 3-Deoxy-3-fluoro-D-glucitol, also known as FDG, is an immensely powerful antidiabetic drug that exhibits significant efficacy in managing type 2 diabetes mellitus. This remarkable medication operates through its ability to impede the glucokinase enzyme, culminating in a notable decline in blood glucose concentrations. Additionally, its intricate mechanism entails the augmentation of insulin sensitivity and facilitation of glucose utilization within the physiological framework. CAS No. 34339-82-7. Molecular formula: C6H13FO5. Mole weight: 184.16. | |
| 5,6-Epoxyeicosatrienoic acid | 5,6-Epoxyeicosatrienoic acid (5,6-EET; (±)5,6-EpETrE) is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. In solution, 5,6-Epoxyeicosatrienoic acid degrades into 5,6-DiHET and 5,6-δ-lactone, which can be converted to 5,6-DiHET and quantified by GC-MS. In neuroendocrine cells, such as the anterior pituitary and pancreatic islets, 5,6-Epoxyeicosatrienoic acid has been implicated in the mobilization of calcium and hormone secretion. 5,6-Epoxyeicosatrienoic acid is an inhibitor of T-type voltage-gated calcium channels (Cav3) that inhibits isoforms Cav3.1, Cav3.2 ( IC 50 =0.54 μM), and Cav3. and decreases nifedipine-resistant phenylephrine-induced vasoconstriction in isolated mouse mesenteric arteries via Cav3.2 blockade when used at a concentration of 3 μM. In addition, it is a substrate of COX-1 and COX-2. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 5,6-EET; (±)5,6-EpETrE. CAS No. 87173-80-6. Pack Sizes: 25 μg (312.04 μM * 250 μL in Ethanol); 50 μg (312.04 μM * 500 μL in Ethanol); 100 μg (312.04 μM * 1 mL in Ethanol). Product ID: HY-132184. |  |
| 5-Hydroxymethylcytidine | 5-Hydroxymethylcytosine is a DNA pyrimidine nitrogen base. It is formed from the DNA base cytosine by adding a methyl group and then a hydroxy group. It is important in epigenetics, because the hydroxymethyl group on the cytosine can possibly switch a gene on and off. It was first seen in bacteriophages in 1952.[1][2] However, in 2009 it was found to be abundant in human and mouse brains,[3] as well as in embryonic stem cells.[4] In mammals, it can be generated by oxidation of 5-methylcytosine, a reaction mediated by the Tet family of enzymes. 5-Hydroxymethylcytidine is a product in DNA hydroxymethylation. The concentrations of 5-Hydroxymethylcytidine in the brain were used to study Alzheimers disease. Group: Biochemicals. Grades: Highly Purified. CAS No. 19235-17-7. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| 7-Azido-4-methylcoumarin (AzMC) | Highly sensitive and selective fluorogenic H2S probe. The aromatic azide moiety of AzMC is selectively reduced in the presence of H2S, producing the fluorescent 7-amino-4- methylcoumarin (AMC) with a concomitant increase in fluorescence with lambdaex=365nm and lambdaem=450nm. Photoaffinity labeling probe for the substrate binding site of human sulfotransferase 1A1 (SULT1A1). Probe to monitor the enzymatic production of H2S in vitro and to visualize H2S in living cells. Tool for monitoring the activity of pyridoxal-5'-phosphate (PLP)-dependent enzymes (e.g. cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CGL) and tryptophan synthase (TS)). Tool to identify novel cystathionine beta-synthase (CBS) inhibitors and activators. Suitable for high-throughput screening. Use of this product with DTT, TCEP and/or biological thiols at concentrations of >25mM should be avoided for maximum efficiency. Group: Biochemicals. Grades: Highly Purified. CAS No. 95633-27-5. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| A-740003 | A-740003 is potent, selective and competitive P2X7 receptor antagonist. Its IC50 values are 18 and 40 nM for rat and human receptors respectively measured by agonist-stimulated changes in intracellular calcium concentrations. It displays selectivity over a variety of P2X and P2Y receptors up to a concentration of 100 μM. It reduces nociception in animal models of persistent neuropathic and inflammatory pain. It showed weak or no activity (IC(50) > 10 muM) at other P2 receptors and an array of other neurotransmitter and peptide receptors, ion channels, reuptake sites, and enzymes. It potently blocked agonist-evoked IL-1beta release (IC(50) = 156 nM) and pore formation (IC(50) = 92 nM) in differentiated human THP-1 cells. It produces significant antinociception in animal models of neuropathic and inflammatory pain in vivo. Uses: A-740003 produces significant antinociception in animal models of neuropathic and inflammatory pain in vivo. Synonyms: A-740003; A 740003; A740003; N-[1-[[(Cyanoamino)(5-quinolinylimino)methyl]amino]-2,2-dimethylpropyl]-3,4-dimethoxybenzeneacetamide;N-(1-{[(cyanoimino)(5-quinolinylamino) methyl] amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide. Grades: >98 %. CAS No. 861393-28-4. Molecular formula: C26H30N6O3. Mole weight: 474.55. | |
| A blend of enzymes for coffee | A unique blend of food grade enzymes, bio-enhancers and naturally available microbes that is used as an effluent treatment in Arabica and Robusta coffee berry processing to depolymerize esterified pectins, fibers, and plant polymers ultimately producing lower concentrations of BOD, COD, TSS and TDS as well as improved clarity and elimination of offensive odor in coffee water. Applications: Coffee berry processing. Group: Enzymes. Coffee enzymes. Appearance: powder or liquid. effluent treatment; offensive odor; coffee water; elimination of offensive odor; in coffee water; depolymerize esterified pectins; enzymes for coffee; depolymerize; A blend of enzymes for coffee. Pack: 25kg/paper barrel (powder form), 30kg/polyster barrel (liquid form). Cat No: TAC-3213. | |
| Adenosylhomocysteinease from Human, Recombinant | S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Adenosylhomocysteinase is an enzyme that converts S-adenosylhomocysteine to homocysteine and adenosine. This enzyme catalyses the following chemical reaction: S-adenosyl-L-homocysteine + H2O<-> L-homocysteine + adenosine. The enzyme contains one tightly bound NAD+ per subunit. Group: Enzymes. Synonyms: Adenosylhomocysteinase; S-adenosylhomocysteine synthase; S-adenosylhomocysteine hydrolase; adenosylhomocysteine hydr. Enzyme Commission Number: EC 3.3.1.1. CAS No. 9025-54-1. AHCY. Mole weight: 47 kDa. Storage: -20°C. Form: Purified and lyophilized powder or Purified, solution in 50% glycerol. Source: Human. Adenosylhomocysteinase; S-adenosylhomocysteine synthase; S-adenosylhomocysteine hydrolase; adenosylhomocysteine hydrolase ambiguous; S-adenosylhomocysteinase; SAHase; AdoHcyase; EC 3.3.1.1; 9025-54-1; AHCY. Cat No: DIA-122. | |
| Albumin | Albumin. CAS No. 9048-49-1. Product ID: PE-0600. Category: Stabilizer; Therapeutic Agents. Product Keywords: Other Materials; Stabilizers; PE-0600; Albumin; Stabilizer; Therapeutic Agents; ; 9048-49-1. Chemical Name: Serum albumin. Grade: Pharmceutical Excipients. Administration route: Intravenous. Dosage Form: Intravenous injection. Stability and Storage Conditions: Albumin is a protein and is therefore prone to chemical degradation and denaturation under extreme pH conditions, high salt concentrations, heat, enzymes, organic solvents and other chemical agents present. Albumin solution should be stored away from light at 2 ~ 25 ° C, or according to label instructions. Source and Preparation: Human blood albumin is a sterile, pyrogen free serum albumin product obtained from a healthy donor's isolate (source blood, plasma, serum or placenta); The source material must not be tested to contain hepatitis B surface antigen. The production process should ensure that the product is safe and can be used for intravenous injection. Applications: Albumin is mainly used as an excipient in the prescription of injectable drugs, as a stabilizer for proteins and enzymes in the prescription. Albumin is also used in the preparation of microspheres and microcapsules in experimental drug delivery systems. As a stabilizer, albumin is used in protein prescriptions at a low concentration of 0.003%. However, concentrations of 1.to 5% are usually |  |
| Alectinib | Alectinib, marketed as Alecensa, is an oral drug that blocks the activity of anaplastic lymphoma kinase (ALK) and is used to treat non-small-cell lung cancer (NSCLC). Alectinib has a low potential for interactions. While it is metabolised by the liver enzyme CYP3A4, and blockers of this enzyme accordingly increase its concentrations in the body, they also decrease concentrations of the active metabolite M4, resulting in only a small overall effect. Conversely, CYP3A4 inducers decrease alectinib concentrations and increase M4 concentrations. Interactions via other CYP enzymes and transporter proteins cannot be excluded but are unlikely to be of clinical significance. Synonyms: CH-5424802; CH5424802; CH 5424802; AF-802; RG-7853; RO5424802. Grades: ≥95%. CAS No. 1256580-46-7. Molecular formula: C30H34N4O2. Mole weight: 482.62. | |
| α-Lipoic Acid | α-Lipoic Acid is a metabolic antioxidant that regulates NFκB signal transduction and can protect against oxidative injury. The exogenous compound is reduced intracellularly by enzymes. Its reduced form is involved in radical scavenging, recycling of other antioxidants, accelerating GSH synthesis, and regulating transcription factor activity, specifically NFkappaB. It also acts as a conenzyme that is required for the activity of pyruvate dehydrogenase and glycine decarboxylase, among other enzyme complexes. Studies show that it can prevent a decrease in the renal antioxidant defense system and prevent the increase of lipid peroxidation, platinum content and plasma creatinine concentrations. In other studies, lipoic acid decreased the phagocytosis of myelin by macrophages, acting as a non-specific scavenger of reactive oxygen species (ROS). Applications: A metabolic antioxidant that regulates nf-κb signal transduction. Group: Coenzymes. Synonyms: DL-Thioctic Acid; DL-6,8-Dithiooctanoic acid; 1,2-Dithiolane-3-valeric acid. CAS No. 1077-28-7. Purity: ≥95%. Mole weight: 206.32. Form: Solid. DL-Thioctic Acid; DL-6,8-Dithiooctanoic acid; 1,2-Dithiolane-3-valeric acid; α-Lipoic Acid; 1077-28-7. Cat No: COEC-041. | |
| Altenusin | Altenusin is a a biphenyl derivative with an IC50 value of 4.3±0.3 μM in the TR assay, which is isolated from the endophytic fungus Alternaria. It inhibits Src kinase with an IC50 value of 20 nM. Altenusin inhibits fibrillization of recombinant tau fragments in vitro and phosphorylation of tau in SH-SY5Y cells expressing human P301L mutant tau when used at a concentration of 10 μM. Altenusin is known to have antioxidant properties and to inhibit several enzymes, including myosin light chain kinase, sphingomyelinase, acetylcholinesterase, cFMS kinase, pp60c-SRc kinase and HIV-1 integrase. Synonyms: Alutenusin; MS 341; MS-341; MS341. Grades: ≥98%. CAS No. 31186-12-6. Molecular formula: C15H14O6. Mole weight: 290.27. | |
| Aminooxyacetic Acid | Aminooxyacetic acid, often abbreviated AOA or AOAA, is a GABA transaminase (GABA-T) inhibitor (Ki = 9.16 μM) that inhibits 4-aminobutyrate aminotransferase (GABA-T) activity in vitro and in vivo, leading to less gamma-aminobutyric acid (GABA) being broken down. Subsequently, the level of GABA is increased in tissues. At concentrations high enough to fully inhibit 4-aminobutyrate aminotransferase activity, aminooxyacetic acid is indicated as a useful tool to study regional GABA turnover in rats. AOAA is also an inhibitor of pyridoxal phosphate (PLP)-dependent enzymes, which serve as an inhibitor by attacking the Schiff base linkage between PLP and the enzyme, forming oxime type complexes. Uses: Gaba agents. Synonyms: Aminooxyacetate; AOAA; 2-Aminooxyacetic acid; U 7524; U7524; U-7524. Grades: ≥95%. CAS No. 645-88-5. Molecular formula: C2H5NO3. Mole weight: 91.07. | |
| aminopeptidase B | Cytosolic or membrane-associated enzyme from mammalian tissues, activated by chloride ions and low concentrations of thiol compounds. This is one of the activities of the bifunctional enzyme EC 3.3.2.6 (membrane alanyl aminopeptidase family). Group: Enzymes. Synonyms: arylamidase II; arginine aminopeptidase; arginyl aminopeptidase; Cl--activated arginine aminopeptidase; cytosol aminopeptidase IV; L-arginine aminopeptidase. Enzyme Commission Number: EC 3.4.11.6. CAS No. 9073-92-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4027; aminopeptidase B; EC 3.4.11.6; 9073-92-1; arylamidase II; arginine aminopeptidase; arginyl aminopeptidase; Cl--activated arginine aminopeptidase; cytosol aminopeptidase IV; L-arginine aminopeptidase. Cat No: EXWM-4027. | |
| Aminopeptidase N Inhibitor | Membrane alanyl aminopeptidase is also known as alanyl aminopeptidase (AAP) or aminopeptidase N (AP-N), which is an enzyme that in humans is encoded by the ANPEP gene. Aminopeptidase N (AP-N) inhibitor is a reversible inhibitor of AP-N/CD13 (IC50 = 25 μM). It is selective for AP-N/CD13 over matrix metalloproteinase-9 (MMP-9), angiotensin converting enzyme (ACE), neutral endopeptidase (NEP), γ-glutamyl transpeptidase, and the serine proteases dipeptidyl peptidase 4 (DPP-4) and cathepsin G at a concentration of 1 mM. AP-N inhibitor is non-cytotoxic to U937 cells at a concentration of 100 μM. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. Synonyms: AP-N Inhibitor. Grades: ≥95%. CAS No. 596108-59-7. Molecular formula: C17H10N2O8. Mole weight: 370.27. | |
| Aprotinin, Bovine (Pancreatic trypsin inhibitor) | Aprotinin is a competitive serine protease inhibitor that inhibits trypsin, chymotrypsin, kallikrein and plasmin. Aprotinin forms stable complexes with and blocks the active sites of enzymes. Binding is reversible with most aprotinin-protease complexes, dissociating at pH >10 or <3. Effective concentration is equimolar with protease. Group: Biochemicals. Alternative Names: Antikrein; Antilysin; Antilysine; Aprostat; Aprotinin; BPTI; BPTI Trypsin Inhibitor; Basic Pancreatic Trypsin Inhibitor; Bayer A 128; Bovine Basic Pancreatic Trypsin Inhibitor; Bovine Pancreatic Trypsin Inhibitor; Bovine Trypsin Inhibitor; Fosten; Kallikrein-trypsin Inactivator; Kiker 52G; Kir Richter; Kunitz Pancreatic Trypsin Inhibitor; Kunitz Protease Inhibitor; Kunitz Trypsin Inhibitor; Kunitz-type Inhibitor; Kunitz-type Proteinase Inhibitor; Kunitz-type Trypsin Inhibitor; Onquinin; Pancreatic Basic Trypsin Inhibitor; Pancreatic Trypsin Inhibitor; Pancreatic Trypsin Inhibitor (Kunitz); Protease Inhibitor, Kunitz Type; RP 9921; Repulson; Trasuylol; Trasylol; Trazinin; Triazinin; Trypsin Inhibitor, Trasylol; Trypsin-kallikrein Inhibitor (Kunitz); Zymofren. Grades: Highly Purified. CAS No. 9087-70-1. Pack Sizes: 100mg, 250mg, 500mg, 1g. Molecular Formula: C???H???N??O??S?, Molecular Weight: 6511.45. US Biological Life Sciences. | Worldwide |
| Aranorosin | Aranorosin is a fungal metabolite originally isolated from P. roseus and an inhibitor of anti-apoptotic functions regulated by Bcl-2. It has antimicrobial activity against B. subtilis, A. niger, and C. albicans when used at a concentration of 1 mg/ml. Aranorosin also reduces viability in apoptosis-resistant HeLa/Bcl-2 cells. Aranorosin also inhibits enzyme AAC(6')/APH(2'') which plays a role in arbekacin (ABK)-resistance in MRSA. Synonyms: Spiro[4,8-dioxatricyclo[5.1.0.03,5]octane-2,2'(3'H)-furan], 2,4-dodecadienamide deriv.; Aranorosine. Grades: ≥95%. CAS No. 117184-53-9. Molecular formula: C23H33NO6. Mole weight: 419.51. | |
| aristolochene synthase | The initial internal cyclization produces the monocyclic intermediate germacrene A; further cyclization and methyl transfer converts the intermediate into aristolochene. While in some species germacrene A remains as an enzyme-bound intermediate, it has been shown to be a minor product of the reaction in Penicillium roqueforti (see also EC 4.2.3.23, germacrene-A synthase). The enzyme from Penicillium roqueforti requires Mg2+. Mn2+ can partially substitute, at low concentrations. Aristolochene is the likely parent compound for a number of sesquiterpenes produced by filamentous fungi. Group: Enzymes. Synonyms: sesquiterpene cyclase; trans,trans-farnesyl diphosphate aristolochene-lyase; trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, aristolochene-forming). Enzyme Commission Number: EC 4.2.3.9. CAS No. 94185-89-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5253; aristolochene synthase; EC 4.2.3.9; 94185-89-4; sesquiterpene cyclase; trans,trans-farnesyl diphosphate aristolochene-lyase; trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, aristolochene-forming). Cat No: EXWM-5253. | |
| Aspartate Kinase (Crude Enzyme) | Aspartate kinase (aspartokinase, aspartic kinase) is an enzyme that catalyzes the phosphorylation of the amino acid aspartate. This reaction is the first step in the biosynthesis of three essential amino acids: methionine, lysine, and threonine, known as the "aspartate family". The gene for aspartokinase is present only in microorganisms and plants; it is not present in animals, which must obtain aspartate-family amino acids in their diet. In Escherichia coli, aspartokinase is present as three independently regulated isozymes, each of which is specific to one of the three downstream biochemical pathways. This allows the independent regulation of the rates of methionine, lysin...pression by high concentrations of their end-products. Absence from animals makes these enzymes key targets for new herbicides and biocides and for improvements in nutritional value of crops. This product with the indicated enzyme activity was briefly purified from engineered E. coli. Applications: Agriculture. Group: Enzymes. Synonyms: aspartokinase; AK; β-aspartokinase; aspartic kinase. Enzyme Commission Number: EC 2.7.2.4. CAS No. 9012-50-4. Activity: Undetermined. Appearance: Clear to translucent yellow solution. Storage: at -20 °C or lower, for at least 1 month. Source: E. coli. aspartokinase; AK; β-aspartokinase; aspartic kinase. Pack: 100ml. Cat No: NATE-1827. | |
| Atazanavir | Atazanavir is a novel and potent azapeptide protease inhibitor that specifically inhibits the human immunodeficiency virus type 1 (HIV-1) protease enzyme with inhibition constant Ki of 66 nmol/L and also inhibits the viral replication of HIV-1 with 50% effective concentration EC50 ranging from 2.6 to 5.3 nmol/L. Atazanavir binds to HIV-1 protease preventing the cleavage of gag and gag-pol polyproteins, which results in the formation of immature virions in HIV-1-infected cells. Atazanavir has a different C-2 symmetric chemical structure and a generally greater antiretroviral potency in various HIV strains compared to other protease inhibitors, including indinavir, nelfinavir, ritonavir, saquinavir and amprenavir. Synonyms: Atazanavir ; Reyataz ; Atazanavir sulfate ; CGP75136 ; CGP75176 ; CGP75355 ; BMS232632 ; CGP 73547 ; CGP 75136 ; CGP 75176 ; CGP 75355 ; CGP-73547 ; CGP-75136 ; CGP-75176 ; CGP-75355 ; BMS 232632 ; BMS-232632 ; BMS-232632-05 ; C413408. Grades: 0.98. CAS No. 198904-31-3. Molecular formula: C38H52N6O7. Mole weight: 704.869. | |
| AZ0108 | AZ0108 is an orally bioavailable, PARP1,2,6 inhibitor that causes a multi-polar spindle phenotype at double digit nM concentrations. AZ0108 has been utilized as in vitro tools and in vivo probes to investigate the biological consequences of inhibiting centrosome clustering through PARP enzymes. Synonyms: (S) -4- ( (3- (3- (1, 1-difluoroethyl) -6-methyl-5, 6, 7, 8-tetrahydro-[1, 2, 4]triazolo[4, 3-a]pyrazine-7-carbonyl) phenyl) difluoromethyl) phthalazin-1 (2H) -one; AZ0108; AZ-0108; AZ 0108. Grades: >98%. CAS No. 1825345-52-5. Molecular formula: C24H20F4N6O2. Mole weight: 500.45. | |
| β-acetylglucosaminidase 73A from Clostridium perfringens, Recombinant | This enzyme releases non-reducing terminal β1-2, β1-3, β1-4 and β1-6 linked N-acetylglucosamine from complex carbohydrates. When incubated with oligosaccharides at low concentrations (<50 mU/ml) the enzyme can differentiate between GlcNAcβ1-2Man, GlcNAcβ1-4Man and GlcNAcβ1-6Man linkages. Under such conditions, the enzyme cleaves essentially only β1-2 linked GlcNAc, with two provisos. Firstly, β1-2 GlcNAc is not hydrolyzed if the mannose to which it is substituted has a substitution at C-6. Thus, the enzyme is useful for the analysis of tri-antennary oligosaccharides. Secondly, if the β-linked mannose of th...etylhexosaminidase; N-Acetyl-β-D-glucosaminidase, β-N-Acetylglucosaminidase. Purity:>90% by SDS-PAGE. β-N-Acetylhexosaminidase. Mole weight: 24.6 kDa. Storage: This enzyme is shipped at room temperature but should be stored at -20 °C. Form: 35 mM NaHepes buffer, pH 7.5, 750 mM NaCl, 200 mM imidazol, 3.5 mM CaCl2, 0.02% sodium azide and 25% (v/v) glycerol. Source: E. coli. Species: Clostridium perfringens. beta-N-acetyl-D-hexosaminide; N-acetylhexosaminohydrolase; β-N-Acetylhexosaminidase; N-Acetyl-β-D-glucosaminidase, β-N-Acetylglucosaminidase; β-Acetylhexosaminidase; β-acetylglucosaminidase 73A. Cat No: NATE-1289. | |
| β-acetylglucosaminidase 73A from Lactococcus lactis, Recombinant | This enzyme releases non-reducing terminal β1-2, β1-3, β1-4 and β1-6 linked N-acetylglucosamine from complex carbohydrates. When incubated with oligosaccharides at low concentrations (<50 mU/ml) the enzyme can differentiate between GlcNAcβ1-2Man, GlcNAcβ1-4Man and GlcNAcβ1-6Man linkages. Under such conditions, the enzyme cleaves essentially only β1-2 linked GlcNAc, with two provisos. Firstly, β1-2 GlcNAc is not hydrolyzed if the mannose to which it is substituted has a substitution at C-6. Thus, the enzyme is useful for the analysis of tri-antennary oligosaccharides. Secondly, if the β-linked mannose of the ...ta;-N-Acetylhexosaminidase; N-Acetyl-β-D-glucosaminidase, β-N-Acetylglucosaminidase. Purity:>90% by SDS-PAGE. β-N-Acetylhexosaminidase. Mole weight: 19.4 kDa. Storage: This enzyme is shipped at room temperature but should be stored at -20 °C. Form: 35 mM NaHepes buffer, pH 7.5, 750 mM NaCl, 200 mM imidazol, 3.5 mM CaCl2, 0.02% sodium azide and 25% (v/v) glycerol. Source: E. coli. Species: Lactococcus lactis. beta-N-acetyl-D-hexosaminide; N-acetylhexosaminohydrolase; β-N-Acetylhexosaminidase; N-Acetyl-β-D-glucosaminidase, β-N-Acetylglucosaminidase; β-Acetylhexosaminidase; β-acetylglucosaminidase 73A. Cat No: NATE-1290. | |
| β-N-Acetylhexosaminidase from Streptococcus pneumoniae, Recombinant | This enzyme releases non-reducing terminal β1-2, β1-3, β1-4 and β1-6 linked N-acetylglucosamine from complex carbohydrates. When incubated with oligosaccharides at low concentrations (<50 mU/ml) the enzyme can differentiate between GlcNAcβ1-2Man, GlcNAcβ1-4Man and GlcNAcβ1-6Man linkages. Under such conditions, the enzyme cleaves essentially only β1-2 linked GlcNAc, with two provisos. Firstly, β1-2 GlcNAc is not hydrolyzed if the mannose to which it is substituted has a substitution at C-6. Thus, the enzyme is useful for the analysis of tri-antennary oligosaccharides. Secondly, if the β-linked mannose of the conserved pentasaccharide core is substituted with a "bisecting" GlcNAc then only the β1-2 linked GlcNAc linked to mannose on the α1-3 arm is cleaved. At higher concentrations of the enzyme, β1-4 and β1-6 linked GlcNAc may also be hydrolyzed. Group: Enzymes. Synonyms: β-N-Acetylhexosaminidase; N-Acetyl-β-D-glucosaminidase, β-N-Acetylglucosaminidase. β-N-Acetylhexosaminidase. Source: E. coli. Species: Streptococcus pneumoniae. β-N-Acetylhexosaminidase; N-Acetyl-β-D-glucosaminidase, β-N-Acetylglucosaminidase. Cat No: NATE-0784. | |
| β-N-Acetylhexosaminidase from Streptococcus pyogenes, Recombinant | This enzyme releases non-reducing terminal β1-2, β1-3, β1-4 and β1-6 linked N-acetylglucosamine from complex carbohydrates. When incubated with oligosaccharides at low concentrations (<50 mU/ml) the enzyme can differentiate between GlcNAcβ1-2Man, GlcNAcβ1-4Man and GlcNAcβ1-6Man linkages. Under such conditions, the enzyme cleaves essentially only β1-2 linked GlcNAc, with two provisos. Firstly, β1-2 GlcNAc is not hydrolyzed if the mannose to which it is substituted has a substitution at C-6. Thus, the enzyme is useful for the analysis of tri-antennary oligosaccharides. Secondly, if the β-linked mannose of the ...ay also be hydrolyzed. Group: Enzymes. Synonyms: beta-N-acetyl-D-hexosaminide; N-acetylhexosaminohydrolase; β-N-Acetylhexosaminidase; N-Acetyl-β-D-glucosaminidase, β-N-Acetylglucosaminidase. Enzyme Commission Number: EC 3.2.1.52. CAS No. 9012-33-3. Purity:> 95 % as judged by SDS-PAGE. β-N-Acetylhexosaminidase. Mole weight: 67487.4 Da. Activity: 5.56 U/mg. Storage: Store at -20°C. Form: Supplied as a freeze-dried powder. Source: Streptococcus pyogenes M1 GAS SF370. beta-N-acetyl-D-hexosaminide; N-acetylhexosaminohydrolase; β-N-Acetylhexosaminidase; N-Acetyl-β-D-glucosaminidase, β-N-Acetylglucosaminidase. Cat No: NATE-1220. | |
| β-N-Acetylhexosaminidase from Xanthomonas manihotis, Recombinant | This enzyme releases non-reducing terminal β1-2, β1-3, β1-4 and β1-6 linked N-acetylglucosamine from complex carbohydrates. When incubated with oligosaccharides at low concentrations (<50 mU/ml) the enzyme can differentiate between GlcNAcβ1-2Man, GlcNAcβ1-4Man and GlcNAcβ1-6Man linkages. Under such conditions, the enzyme cleaves essentially only β1-2 linked GlcNAc, with two provisos. Firstly, β1-2 GlcNAc is not hydrolyzed if the mannose to which it is substituted has a substitution at C-6. Thus, the enzyme is useful for the analysis of tri-antennary oligosaccharides. Secondly, if the β-linked mannose of the ...cing β-n-acetylglucosamine residues from oligosaccharides. Applications: Biosynthesis of glycans in eukaryotes, glycoprotein production in various expression systems, protein digestion, removal of n-linked & o-linked glycans from glycoproteins, sequencing glycans. Group: Enzymes. Synonyms: β-N-Acetylhexosaminidase; N-Acetyl-β-D-glucosaminidase, β-N-Acetylglucosaminidase. β-N-Acetylhexosaminidase. Mole weight: 71000 daltons. Storage: 4°C, Avoid repeated freeze/thaw cycles. Source: E.coli. Species: Xanthomonas manihotis. β-N-Acetylhexosaminidase; N-Acetyl-β-D-glucosaminidase, β-N-Acetylglucosaminidase. Cat No: NATE-0934. | |
| β-Nicotinamide adenine dinucleotide, reduced disodium salt | β-Nicotinamide adenine dinucleotide can be used in enzyme cycling assays to amplify detection of activity of biologically relevant enzymes or metabolites present in low concentrations. Applications: A regenerating electron donor coenzyme. Group: Coenzymes. Synonyms: β-DPNH; β-NADH; DPNH, Diphosphopyridine nucleotide, reduced form; NADH. CAS No. 606-68-8. Purity: ≥94%. Mole weight: 709.4. Appearance: Powder. Form: Solid. β-DPNH; β-NADH; DPNH, Diphosphopyridine nucleotide, reduced form; NADH; β-Nicotinamide adenine dinucleotide, reduced disodium salt; 606-68-8. Cat No: COEC-050. | |
| bis-γ-glutamylcystine reductase | Contains FAD. The enzyme, which is found only in halobacteria, maintains the concentration of γ-glutamylcysteine, the major low molecular weight thiol in halobacteria. Not identical with EC 1.8.1.7 (glutathione-disulfide reductase) or EC 1.8.1.14 (CoA-disulfide reductase). Group: Enzymes. Synonyms: NADPH2:bis-γ-glutamylcysteine oxidoreductase; GSR. Enzyme Commission Number: EC 1.8.1.13. CAS No. 117056-54-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1639; bis-γ-glutamylcystine reductase; EC 1.8.1.13; 117056-54-9; NADPH2:bis-γ-glutamylcysteine oxidoreductase; GSR. Cat No: EXWM-1639. | |
| Bromoenol lactone | BEL is a selective, potent, irreversible, mechanism-based inhibitor of myocardial cytosolic calcium-independent phospholipase A2 (iPLA2) with a Ki value of 180 nM. BEL induces the proteolysis of procaspase-9 and procaspase-3 and increases cleavage of poly (ADP-ribose) polymerase. BEL also inhibits macrophage iPLA2 in a concentration-dependent manner with an IC50 value of 60 nM and is an effective enzyme-activated irreversible inhibitor of chymotrypsin Ki of 636 nM. Long term treatment with BEL increased annexin-V binding to the cell surface and nuclear DNA damage. Synonyms: BEL; Haloenol lactone; HELSS. Grades: ≥95%. CAS No. 88070-98-8. Molecular formula: C16H13BrO2. Mole weight: 317.2. | |
| Bse21 I | One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA (HindIII-digest) in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 2-fold overdigestion with enzyme about 50% of dna fragments can be ligated by using of high concentration t4 dna ligase with presence of 10% peg. of these more than 90% can be recut. Group: Restriction Enzymes. Purity: 500 U; 2500U. CC↑TNAGG GGANT↓CC. Activity: 20000u.a./ml. Appearance: 10 X SE-buffer Y. Storage: -20°C. Form: Liquid. Source: Bacillus species 21. Pack: 10 mM KH2PO4 (pH 7.4); 50 mM KCl; 0.1 mM EDTA; 7 mM 2-mercaptoethanol; 200 μg/ml BSA; 50% glycerol. Cat No: ET-1045RE. | |
| calpain-1 | In peptidase family C2. Requires Ca2+ at micromolar concentrations for activity. Cytosolic in animal cells. The active enzyme molecule is a heterodimer in which the large subunit contains the peptidase unit, and the small subunit is also a component of EC 3.4.22.53, calpain-2. Group: Enzymes. Synonyms: μ-calpain; calcium-activated neutral protease I. Enzyme Commission Number: EC 3.4.22.52. CAS No. 78990-62-2. Calpain 1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4227; calpain-1; EC 3.4.22.52; 78990-62-2; μ-calpain; calcium-activated neutral protease I. Cat No: EXWM-4227. | |
| calpain-2 | Type example of peptidase family C2. Requires Ca2+ at millimolar concentrations for activity. Cytosolic in animal cells. The active enzyme molecule is a heterodimer in which the large subunit contains the peptidase unit, and the small subunit is also a component of EC 3.4.22.52, calpain-1. Group: Enzymes. Synonyms: calcium-activated neutral protease II; m-calpain; milli-calpain. Enzyme Commission Number: EC 3.4.22.53. CAS No. 702693-80-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4228; calpain-2; EC 3.4.22.53; 702693-80-9; calcium-activated neutral protease II; m-calpain; milli-calpain. Cat No: EXWM-4228. | |
| carnosine synthase | This enzyme was thought to form AMP, but studies with highly purified enzyme proved that it forms ADP. Carnosine is a dipeptide that is present at high concentrations in skeletal muscle and the olfactory bulb of vertebrates. It is also found in the skeletal muscle of some invertebrates. The enzyme can also catalyse the formation of homocarnosine from 4-aminobutanoate and L-histidine, with much lower activity. Group: Enzymes. Synonyms: carnosine synthetase; carnosine-anserine synthetase; homocarnosine-carnosine synthetase; carnosine-homocarnosine synthetase;L-histidine:β-alanine ligase (AMP-forming) (incorrect). Enzyme Commission Number: EC 6.3.2.11. CAS No. 9023-61-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5732; carnosine synthase; EC 6.3.2.11; 9023-61-4; carnosine synthetase; carnosine-anserine synthetase; homocarnosine-carnosine synthetase; carnosine-homocarnosine synthetase;L-histidine:β-alanine ligase (AMP-forming) (incorrect). Cat No: EXWM-5732. | |
| Catalase, Laboratory Grade, 1 mL | Dilute 1 mL catalase to 715 mL with distilled water for a final concentration of 400 IU/mL; converts hydrogen peroxide to oxygen and water; keep refrigerated; oxidizing enzyme. This product has a shelf life of 6 months from date of receipt. Health Risk: 1. Flammability: 1. Reactivity: 0. Grades: chem-grade laboratory. CAS No. 9001-5-2. Product ID: 853530. -- SOLD FOR EDUCATIONAL USE ONLY -- |  |
| Catalase, Laboratory Grade, 5 mL | Dilute 1 mL catalase to 715 mL with distilled water for a final concentration of 400 IU/mL; converts hydrogen peroxide to oxygen and water; keep refrigerated; oxidizing enzyme. This product has a shelf life of 6 months from date of receipt. Health Risk: 1. Flammability: 1. Reactivity: 0. Grades: chem-grade laboratory. CAS No. 9001-5-2. Product ID: 853532. -- SOLD FOR EDUCATIONAL USE ONLY -- | |
| Cepharanthine | Cepharanthine is a natural product that can be isolated from the plant Stephania?cephalantha?Hayata. Cepharanthine has anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) activities. Cepharanthine has good effective in suppressing viral proliferation (half maximal (50%) inhibitory concentration ( IC 50 ) and 90% inhibitory concentration ( IC 90 ) values of 1.90 and 4.46?μM [1]. Cepharanthine can also effectively reverses P-gp-mediated multidrug resistance in K562 cells and increase enhances the sensitivity of anticancer agents in xenograft mice model [2] [3]. Cepharanthine shows inhibitory effects of human liver cytochrome P450 enzymes CYP3A4, CYP2E1 and CYP2C9. Cepharanthine has antitumor, anti-inflammatory and antinociceptive effects [4] [5] [6] [7] [8]. Uses: Scientific research. Group: Natural products. CAS No. 481-49-2. Pack Sizes: 10 mM * 1 mL; 50 mg. Product ID: HY-N6972. | |
| Checkpoint Kinase 2, Active Human, Recombinant | CHEK2 is the official symbol for the human gene Checkpoint kinase 2. CHEK2 is located on the the long (q) arm of chromosome 22. CHEK2 is tumor suppressor gene that encodes the protein CHK2, a serine threonine kinase. CHK2 operates in an intricate network of proteins to elicit DNA repair, cell cycle arrest or apoptosis in response to DNA damage. Mutations to the CHEK2 gene have been linked to a wide range of cancers including breast cancer. Buffered aqueous glycerol solution, recombinant, expressed in e. coli, > 85% (sds-page). Applications: Kinase activity is measured as the molar amount of phosphate incorporated into the chktide per minute per mg protein at 30°c using a final concentration of 50 μm [32p] atp. Group: Enzymes. Synonyms: Checkpoint Kinase 2; CHEK2; CDS1; CHK2; HuCds1; LFS2; PP1425; RAD53; hCds1; Chek2; Chk2. Purity: > 85% (SDS-PAGE). CHEK2. Mole weight: protein apparent mol wt ~88 kDa. Stability: -70°C. Form: buffered aqueous glycerol solution. Source: E. coli. Species: Human. Checkpoint Kinase 2; CHEK2; CDS1; CHK2; HuCds1; LFS2; PP1425; RAD53; hCds1; Chek2; Chk2. Cat No: NATE-0122. | |
| chondroitin AC lyase | Acts on chondroitin 4-sulfate and chondroitin 6-sulfate, but less well on hyaluronate. In general, chondroitin sulfate (CS) and dermatan sulfate (DS) chains comprise a linkage region, a chain cap and a repeat region. The repeat region of CS is a repeating disaccharide of glucuronic acid (GlcA) and N-acetylgalactosamine (GalNAc) [-4)GlcA(β1-3)GalNAc(β1-]n, which may be O-sulfated on the C-4 and/or C-6 of GalNAc and C-2 of GlcA. GlcA residues of CS may be epimerized to iduronic acid (IdoA) forming the repeating disaccharide [-4)IdoA(α1-3)GalNAc(β1-]n of DS. Both the concentrations and locations of sulfate-ester substituents vary with glucosaminoglycan source. Group: Enzymes. Synonyms: chondroitinase (ambiguous); chondroitin sulfate lyase; chondroitin AC eliminase; chondroitinase AC; ChnAC. Enzyme Commission Number: EC 4.2.2.5. CAS No. 9047-57-8. ChnAC. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5104; chondroitin AC lyase; EC 4.2.2.5; 9047-57-8; chondroitinase (ambiguous); chondroitin sulfate lyase; chondroitin AC eliminase; chondroitinase AC; ChnAC. Cat No: EXWM-5104. | |
| chondroitin B lyase | This is the only lyase that is known to be specific for dermatan sulfate as substrate. The minimum substrate length required for catalysis is a tetrasaccharide. In general, chondroitin sulfate (CS) and dermatan sulfate (DS) chains comprise a linkage region, a chain cap and a repeat region. The repeat region of CS is a repeating disaccharide of glucuronic acid (GlcA) and N-acetylgalactosamine (GalNAc) [-4)GlcA(β1-3)GalNAc(β1-]n, which may be O-sulfated on the C-4 and/or C-6 of GalNAc and C-2 of GlcA. GlcA residues of CS may be epimerized to iduronic acid (IdoA) forming the repeating disaccharide [-4)IdoA(α1-3)GalNAc(β1-]n of DS. Both the concentrations and locations of sulfate-ester substituents vary with glucosaminoglycansource. Group: Enzymes. Synonyms: chondroitinase B; ChonB; ChnB. Enzyme Commission Number: EC 4.2.2.19. CAS No. 52227-83-5. ChonB. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5094; chondroitin B lyase; EC 4.2.2.19; 52227-83-5; chondroitinase B; ChonB; ChnB. Cat No: EXWM-5094. | |
| CJ-42794 | CJ-42794 is a selective prostaglandin E receptor subtype 4 (EP4) antagonist. It inhibits [3H]-PGE2 binding to the human EP4 receptor with a mean pKi of 8.5. It competitively antagonized cAMP accumulation with a pA2 value of 8.7 in HEK293 cells overexpressing rat prostanoid EP4 receptors. It did not exhibit any remarkable binding to 65 additional proteins, including GPCRs, enzymes, and ion channels. It reversed the inhibitory effects of PGE2 on LPS-induced TNFα production in a concentration-dependent manner. It has excellent pharmacological properties that make it a useful tool for exploring the physiological role of EP4 receptors. Uses: Cj-42794 has excellent pharmacological properties that make it a useful tool for exploring the physiological role of ep4 receptors. Synonyms: CJ-042794; CJ 042794; CJ042794; RQ-00015986, RQ-15986. 4-[ (1S) -1-[[5-chloro-2- (4-fluorophenoxy) benzoyl]amino]ethyl]benzoic acid; (S) -4- (1- (5-chloro-2- (4-fluorophenoxy) benzaMido) ethyl) benzoic acid;CJ-042794;4-((S)-1-(2-(4-fluorophenoxy)-5-chlorobenzamido)ethyl)benzoic acid. Grades: >98%. CAS No. 847728-01-2. Molecular formula: C22H17ClFNO4. Mole weight: 413.83. | |
| Corydine | Corydine is a naturally occurring alkaloid which can be extracted from plants such as Croton echinocarpus leaves. Corydine is efficient on inhibiting reverse transcriptase (RT) activity with an IC50 of 356.8 μg/mL. Corydine displays significant in vitro anti-HIV potential, inhibiting 40% of the HIV-1 reverse transcriptase enzyme activity at a concentration of 450 μg/mL of Corydine. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Glaucentrine. Product Category: Inhibitors. CAS No. 476-69-7. Molecular formula: C20H23NO4. Mole weight: 341.4. Purity: 90%+. Product ID: ACM476697. Alfa Chemistry ISO 9001:2015 Certified. Categories: Cordiner Peaks. |  |
| Creatinase, microorganism | Creatine amidinohydrolase, microorganism is a hydrolytic enzyme that catalyzes the hydrolysis of creatine into creatinine and urea, playing a crucial role in the measurement of creatinine concentration. Creatine amidinohydrolase, microorganism can be used in the development of biosensors for measuring serum creatinine levels [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Creatine amidinohydrolase, microorganism. CAS No. 37340-58-2. Pack Sizes: 1 KU; 5 KU. Product ID: HY-P2893B. | |
| Cytochlor | Cytochlor is a radio-sensitizing pyrimidine nucleoside with potential antineoplastic activity. Cytochlor is metabolized first to a phosphate derivative, CldCMP, by the enzyme deoxycytidine kinase and then to the active uracyl derivative, CldUMP, by the enzyme dCMP deaminase; deoxycytidine kinase and dCMP deaminase have been found in abnormally high concentrations in most cancers. CldUMP, the active metabolite, incorporates into DNA and, upon exposure to radiation, induces the formation of uracil radicals and double-strand DNA breaks. Synonyms: 5-Chloro-2'-deoxycytidine; 5-Chlorodeoxycytidine; 2'-Deoxy-5-chlorocytidine; NSC-371331; NSC 371331. Grades: ≥ 97%. CAS No. 32387-56-7. Molecular formula: C9H12ClN3O5. Mole weight: 261.66. | |
| D-Eritadenine | D-Eritadenine is an adenosine analog and a potent, reversible inhibitor of S-adenosylhomocysteine hydrolase. Dietary administration of D-eritadenine (50 mg/kg) increases liver microsomal phosphatidylethanolamine concentration and decreases liver microsomal Δ6 desaturase activity and plasma cholesterol levels in rats. Uses: Enzyme inhibitors. Synonyms: (αR,βR)-6-Amino-α,β-dihydroxy-9H-purine-9-butanoic Acid; 4-(6-Amino-9H-purin-9-yl)-4-deoxy-D-erythronic Acid; 4-(6-Aminopurin-9-yl)-4-deoxy-D-erythronic Acid; Lentinacin; Lentysine; 4-(9-Adenyl)-D-erythro-2,3-dihydroxybutyric Acid; Eritadenine; Lentysine; Lentinacin. Grades: ≥95%. CAS No. 23918-98-1. Molecular formula: C9H11N5O4. Mole weight: 253.21. | |
| Diguanylate Cyclase from Agrobacterium vitis, recombinant | The diguanylate cyclase from Agrobacterium vitis has been engineered to remove phosphodiesterase activity, allowing for production of cyclic-diGMP from guanosine triphosphate (GTP) without the production of 5'-phosphoguanylyl-(3',5')-guanosine (pGpG). Applications: Useful for producing cyclic-digmp from gtp without production of pgpgcompletely lacks unwanted phosphodiesterase activityno product inhibition even at high concentrations of gtpremains active while immobilized to solid resin and retain enzymatic activity after several months of storagecan be used to synthesize radiolabeled cyclic digmp from radiolabeled gtp. Group: Enzymes. Synonyms: DGC; PleD; EC 2.7.7.65; 146316-82-7; Engineered Diguanylate Cyclase. Enzyme Commission Number: EC 2.7.7.65. CAS No. 146316-82-7. Purity: >99% based on SDS-PAGE analysis with coomassie blue. Mole weight: 56 kDa. Activity: 7.5 nmol min-1. Storage: at -80 °C; Multiple freeze/thaw cycles are not recommended. Form: Liquid. Source: E. coli. Species: Agrobacterium vitis. Diguanylate cyclase; DGC; PleD; EC 2.7.7.65; 146316-82-7; Engineered Diguanylate Cyclase. Cat No: NATE-1692. | |
| dihydromethanopterin reductase [NAD(P)+] | The enzyme, characterized from the bacterium Methylobacterium extorquens, is involved in biosynthesis of dephospho-tetrahydromethanopterin. The specific activity with NADH is 15% of that with NADPH at the same concentration. It does not reduce 7,8-dihydrofolate (cf. EC 1.5.1.3, dihydrofolate reductase). Group: Enzymes. Synonyms: DmrA; H2MPT reductase; 5,6,7,8-tetrahydromethanopterin 5,6-oxidoreductase; dihydromethanopterin reductase. Enzyme Commission Number: EC 1.5.1.47. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1528; dihydromethanopterin reductase [NAD(P)+]; EC 1.5.1.47; DmrA; H2MPT reductase; 5,6,7,8-tetrahydromethanopterin 5,6-oxidoreductase; dihydromethanopterin reductase. Cat No: EXWM-1528. | |
| D-Luciferin | D-luciferin is the natural substrate of the enzyme luciferase (Luc) that catalyzes the production of the typical yellowgreen light of fireflies. The 560 nm chemiluminescence from this reaction peaks within seconds, with light output that is proportional to luciferase concentration when the substrate luciferin is present in excess. The luciferase (luc) gene is a popular reporter gene for research and agent screening. Chemiluminescent techniques are virtually background-free, making the luc reporter gene ideal for detecting low-level gene expression. As little as 0.02 pg of luciferase can be reliably measured in a standard scintillation counter. In addition to its role as a reporter of gene expression, luciferase is commonly used in an extremely sensitive assay for ATP [1]. We of er the firefly luciferase (HY-P1004), luciferin free acid (HY-12591A), as well as its water-soluble sodium salts (HY-12591) and potassium salts (HY-12591B). Uses: Scientific research. Group: Fluorescent dye. Alternative Names: D-(-)-Luciferin; Firefly luciferin; Beetle Luciferin. CAS No. 2591-17-5. Pack Sizes: 5 mg; 10 mg; 50 mg. Product ID: HY-12591A. | |
| D-Luciferin potassium | D-luciferin is the natural substrate of the enzyme luciferase (Luc) that catalyzes the production of the typical yellowgreen light of fireflies. The 560 nm chemiluminescence from this reaction peaks within seconds, with light output that is proportional to luciferase concentration when the substrate luciferin is present in excess. The luciferase (luc) gene is a popular reporter gene for research and agent screening. Chemiluminescent techniques are virtually background-free, making the luc reporter gene ideal for detecting low-level gene expression. As little as 0.02 pg of luciferase can be reliably measured in a standard scintillation counter. In addition to its role as a reporter of gene expression, luciferase is commonly used in an extremely sensitive assay for ATP [1]. We offer the firefly luciferase (HY-P1004), luciferin free acid (HY-12591A), as well as its water-soluble sodium salts (HY-12591) and potassium salts (HY-12591B). Uses: Scientific research. Group: Fluorescent dye. Alternative Names: D-(-)-Luciferin potassium; Firefly luciferin potassium; Beetle Luciferin potassium. CAS No. 115144-35-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-12591B. | |
| D-Luciferin sodium | D-luciferin is the natural substrate of the enzyme luciferase (Luc) that catalyzes the production of the typical yellowgreen light of fireflies. The 560 nm chemiluminescence from this reaction peaks within seconds, with light output that is proportional to luciferase concentration when the substrate luciferin is present in excess. The luciferase (luc) gene is a popular reporter gene for research and agent screening. Chemiluminescent techniques are virtually background-free, making the luc reporter gene ideal for detecting low-level gene expression. As little as 0.02 pg of luciferase can be reliably measured in a standard scintillation counter. In addition to its role as a reporter of gene expression, luciferase is commonly used in an extremely sensitive assay for ATP [1]. We of er the firefly luciferase (HY-P1004), luciferin free acid (HY-12591A), as well as its water-soluble sodium salts (HY-12591) and potassium salts (HY-12591B). Uses: Scientific research. Group: Fluorescent dye. Alternative Names: D-(-)-Luciferin sodium; Firefly luciferin sodium; Beetle Luciferin sodium. CAS No. 103404-75-7. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12591. | |
| Elacridar | Elacridar hydrochloride (GF120918A) is a P-glycoprotein inhibitor, and has been used both in vitro and in vivo as a tool inhibitor of P-glycoprotein (Pgp) to investigate the role of transporters in the disposition of various test molecules. In vitro, GF120918A demonstrated high plasma protein binding across species, although a definitive protein binding evaluation was precluded by poor recovery, particularly in buffer and in mouse, rat, and dog plasma. GF120918A did not demonstrate potent inhibition of several human cytochrome P450 enzymes evaluated in vitro, with IC(50) values well above concentrations anticipated to be achieved in vivo. Together, these data confirm the utility of GF120918A as a tool P-glycoprotein inhibitor in preclinical species and offer additional guidance on preclinical dose regimens likely to produce P-glycoprotein-mediated effects. Synonyms: GF120918; GF-120918; GF 120918; GF-120918A; GF120918A; GF 120918A; GG 918; D03968. Elacridar hydrochloride. CAS No. 143664-11-3. Molecular formula: C34H33N3O5. Mole weight: 563.654. | |
| Enzyme for premix feed---PME | PME is specially developed for premix feed and Farm with a characteristic of concentration enzyme. The results of practical experiments showed using this enzyme preparation could save enough space of diet composition and keep the stable feed quality. It is applied in feed with lower addition due to the high bioavailability value. Ingredients: cellulose; β-glucanase; Xylanase; etc. Applications: 1. higher bioavailability value but lower addition. 2. pme is concentration enzyme, then save the storage space. 3. make up inadequate secretion of endogenous enzyme of animal to improve animal feed intake and feed efficiency; 4. by means of breaking down anti-nutritional factors in feed, to improve digestion and absorption of the dietary energy and protein; 5. reducing the differences between different batches of feed, to steady products' quality; 6. it can reduce nitrogen and phosphorus excretion, to reduce environmental pollution. Group: Enzymes. Synonyms: premix feed;PME; Feed Grade Enzymes; enzymes for laying hen; Enzyme for premix feed; PME; improve animal feed intake; Enzyme for premix feed---PME;. PME. Appearance: pellet. premix feed;PME; Feed Grade Enzymes; enzymes for laying hen; Enzyme for premix feed; PME; improve animal feed intake; Enzyme for premix feed---PME; FEED-2330. Pack: 25kg/barrel or subject to client requirement. Cat No: FEED-2330. | |
| ES 936 | ES 936 is a potent and specific NQO1 inhibitor, effective at concentrations over 1000 times lower than the non-specific inhibitor Dicoumarol (HY-N0645). NQO1 is generally considered a detoxification enzyme, capable of directly reducing quinones to hydroquinones, which in turn prevents the formation of reactive oxygen species arising from redox cycling. ES 936 can be utilized in cancer research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 192820-78-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-100367. | |
| Ethonafide | Ethonafide is an anthracene-containing derivative of amonafide that belongs to the azonafide series of anticancer agents. The lack of cross-resistance in multidrug-resistant cancer cell lines and the absence of a quinone and hydroquinone moiety make ethonafide a potentially less cardiotoxic replacement for existing anthracene-containing anticancer agents. Ethonafide was cytotoxic against three human prostate cancer cell lines at nanomolar concentrations. Ethonafide was found to be better tolerated and more effective at inhibiting tumor growth compared with mitoxantrone in a human xenograft tumor regression mouse model. Mechanistically, we found that ethonafide inhibited topoisomerase II activity by stabilizing the enzyme-DNA complex, involving both topoisomerase IIalpha and -beta. In addition, ethonafide induced a potent G(2) cell cycle arrest in the DU 145 human prostate cancer cell line. By creating stable cell lines with decreased expression of topoisomerase IIalpha or -beta, we found that a decrease in topoisomerase IIalpha protein expression renders the cell line resistant to ethonafide. The decrease in sensitivity to ethonafide was associated with a decrease in DNA damage and an increase in DNA repair as measured by the neutral comet assay. These data demonstrate that ethonafide is a topoisomerase II poison and that it is topoisomerase IIalpha-specific in the DU 145 human prostate cancer cell line. Uses: Topoisomerase ii inhibitors. Synonyms: AMP-53; AMP 53; AMP53; 2-(2'-(Dimethylamino)ethyl)-1,2-dihydro-7-ethoxydibenz(de, H)isoquinoline-1,3-dione; 2-[2-(Dimethylamino)ethyl]-7-ethoxy-1H-dibenz[de,h]isoquinoline-1,3(2H)-dione. CAS No. 175293-23-9. Molecular formula: C22H22N2O3. Mole weight: 362.43. | |
| Frenatin 3 | Frenatin 3 inhibits the production of nitric oxide by the enzyme neuronal nitric oxide synthase at a micromolar concentration by binding to its regulatory protein, Ca2+ calmodulin, a protein known to recognize and bind amphipathic alpha-helices. Grades: >95% by HPLC. Molecular formula: C88H146N24O24S. Mole weight: 1956.31. | |
| γ-[(6-Aminohexyl)imido]-ATP - Texas Red | γ-[(6-Aminohexyl)imido]-ATP - Texas Red is a fluorescent ATP analogue used as a research tool to visualize and measure cellular ATP concentrations in real time. It has also been utilized in studies to investigate cellular energy metabolism and enzyme kinetics, as well as neuronal signaling pathways. Synonyms: γ-[(6-Aminohexyl)-imido]-adenosine-5'-triphosphate, labeled with Texas Red, Triethylammonium salt. Grades: ≥ 95 % by HPLC. Molecular formula: C53H69N10O19P3S2(free acid). Mole weight: 1306.34 (free acid). | |
| GC Enhancer | GC Enhancer. Gc enhancer should be used with dna ploymerase to optimize pcr from complex templates including gc rich. the storage concentration is 10×. the working concentration can adjust between 0.5×-5×. Group: Cloning Enzymes. Purity: 200ul. Storage: Store at -20 ?. Cat No: CE-3007. | |
| GIRK Activator, ML297 (1-(3,4-Difluorophenyl)-3-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea, N-(3,4-Difluorophenyl)-N?-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea, CID 56642816, VU0456810) | A blood-brain barrier-permeable, non-toxic phenyl-pyrazolylurea compound that acts as a direct, potent, fast, and reversible activator of GIRK1 (G-protein activated inward-rectifying K+ channel containing subunit 1) containing channels (EC50 = 162, 914, and 887nM in Thallium influx assay for GIRK1/2, GIRK1/3, and GIRK1/4 expressed in HEK-293 cell lines). Its action does not require the presence of an activated Gi GPCR. Shown to be inactive towards GIRK2, GIRK2/3, Kir2.1, KV7.4 and GABAA, and weakly active against a panel of 61 other receptors, ion channels, enzymes, transporters, and proteins even at higher concentration (~10uM). Exhibits desirable pharmacokinetic properties with good solubility (17.5uM), predicted hepatic clearance (88 ml/min/kg), and Tmax of 640nM and 130nM in plasma and brain, respectively. Shown to reduce locomotor function and seizure frequency in electroshock- and chemically-induced murine epilepsy models (60mg/kg, i.p). Group: Biochemicals. Grades: Highly Purified. CAS No. 1443246-62-5. Pack Sizes: 10mg. Molecular Formula: C??H??F?N?O. US Biological Life Sciences. | Worldwide |
| Glutamine Synthetase from Human, recombinant | GLUL also known as Glutamine synthetase. It is a trimetallic enzyme containing two divalent cation sites and one monovalent cation site per subunit. GLUL is able to regulate intracellular concentrations of glutamate and catalyzes the synthesis of glutamine form glutamate and ammonia. It is ubiquitously expressed in the human and plays a major role for many metabolic pathways such as cell proliferation, inhibition of apoptosis, and cell signaling. Recombinant Human GLUL was expressed in E.coli and purified by using conventional chromatography techniques. Group: Enzymes. Synonyms: Glutamine synthetase; GS; EC 6.3.1.2; Glutamate-ammonia ligase; GLNS; PIG43; PIG59; GLUL. Enzyme Commission Number: EC 6.3.1.2. CAS No. 9023-70-5. Purity: > 85% by SDS-PAGE. GS. Mole weight: 42 kDa. Activity: > 2.000 pmol/min/ug. Storage: Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -70°C. Avoid repeated freezing and thawing cycles. Form: Liquid. Source: E. coli. Species: Human. Glutamine synthetase; GS; EC 6.3.1.2; Glutamate-ammonia ligase; GLNS; PIG43; PIG59; GLUL. Cat No: NATE-1675. | |
| GPI-15427 | GPI-15427 is a potent PARP-1 inhibitor capable of crossing the blood-brain barrier, which can significantly increased the antitumor activity of the methylating agent TMZ against malignant melanoma, glioblastoma multiforme, or lymphoma growing at the CNS site. GPI-15427 acts as a potent inhibitor of the enzyme, being capable of inhibiting the activity of purified PARP-1 at nanomolar concentrations. GPI-15427 induced significant sensitization to radiotherapy, representing a promising new treatment in the management of HNSCC. Uses: Poly(adp-ribose) polymerase inhibitors. Synonyms: GPI 15427; GPI15427; 10-((4-Methylpiperazin-1-yl)methyl)chromeno(4,3,2-de)phthalazin-3(2H)-one. CAS No. 805242-85-7. Molecular formula: C20H20N4O2. Mole weight: 348.41. | |
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