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Product | Description | |
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2,5:3,4-Dianhydro-6-O-2-propenyl-dimethyl acetal-L-talose Quick inquiry Where to buy Suppliers range | 2,5:3,4-Dianhydro-6-O-2-propenyl-dimethyl acetal-L-talose is a multifaceted compound frequently implemented in scientific pursuit, utilized for the estimation of diseases associated with the abnormal metabolism of carbohydrates. Its potency lies in the inhibition of the enzyme α-glucosidase, crucial for carbohydrate catabolism within the body. Diminishing the enzymatic activity results in a significant drop in systemic glucose concentration, thus exhibiting a potential remedy for the management of Type II diabetes and correlated ailments. Synonyms: (1R,2R,4S)-2-(Dimethoxymethyl)-4-(prop-2-enoxymethyl)-3,6-dioxabicyclo[3.1.0]hexane. CAS No. 473796-96-2. Molecular formula: C11H18O5. Mole weight: 230.26. | |
2,6-Dichlorophenolindophenyl acetate Quick inquiry Where to buy Suppliers range | 2,6-Dichlorophenolindophenyl acetate, a prominent biochemical, holds substantial significance in determining ascorbic acid concentrations. Its multidimensional application extends to serving as a redox indicator to detect biomarkers of various viruses and diseases in enzyme-linked immunosorbent assays (ELISA). Synonyms: DIPA; 4-[(2,3-dichloro-4-oxocyclohexa-2,5-dien-1-yl)imino]phenyl acetate. CAS No. 24857-20-3. Molecular formula: C14H9Cl2NO3. Mole weight: 310.13. | |
(2R)-2-hydroxy-3-(hydroxymethyl)-3-methyl-N-(3-oxo-4-phenylbutyl)butanamide Quick inquiry Where to buy Suppliers range | (2R)-2-hydroxy-3-(hydroxymethyl)-3-methyl-N-(3-oxo-4-phenylbutyl)butanamide or RR6 is an inhibitor of Vanin which is an enzyme that play a role in the recycling of pantothenic acid (vitamin B5) from pantetheine. Alterations in plasma lipid concentrations in rats caused by RR6 indicates its potential usefulness. Group: Biochemicals. Grades: Highly Purified. CAS No. 1351758-37-6. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C16H23NO4, Molecular Weight: 293.36. US Biological Life Sciences. | Worldwide |
(2R)-2-hydroxy-3-(hydroxymethyl)-3-methyl-N-(3-oxo-4-phenylbutyl)butanamide-d5 Quick inquiry Where to buy Suppliers range | (2R)-2-hydroxy-3-(hydroxymethyl)-3-methyl-N-(3-oxo-4-phenylbutyl)butanamide-d5 or RR6 (vanin inhibitor)-d5 is the labelled analogue of 2R)-2-hydroxy-3-(hydroxymethyl)-3-methyl-N-(3-oxo-4-phenylbutyl)butanamide or RR6 (vanin inhibitor) which is an enzyme that play a role in the recycling of pantothenic acid (vitamin B5) from pantetheine. Alterations in plasma lipid concentrations in rats caused by RR6 indicates its potential usefulness. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C16H18D5NO4, Molecular Weight: 298.39. US Biological Life Sciences. | Worldwide |
3-Deoxy-3-fluoro-D-glucitol Quick inquiry Where to buy Suppliers range | 3-Deoxy-3-fluoro-D-glucitol, also known as FDG, is an immensely powerful antidiabetic drug that exhibits significant efficacy in managing type 2 diabetes mellitus. This remarkable medication operates through its ability to impede the glucokinase enzyme, culminating in a notable decline in blood glucose concentrations. Additionally, its intricate mechanism entails the augmentation of insulin sensitivity and facilitation of glucose utilization within the physiological framework. CAS No. 34339-82-7. Molecular formula: C6H13FO5. Mole weight: 184.16. | |
5-Hydroxymethylcytidine Quick inquiry Where to buy Suppliers range | 5-Hydroxymethylcytosine is a DNA pyrimidine nitrogen base. It is formed from the DNA base cytosine by adding a methyl group and then a hydroxy group. It is important in epigenetics, because the hydroxymethyl group on the cytosine can possibly switch a gene on and off. It was first seen in bacteriophages in 1952.[1][2] However, in 2009 it was found to be abundant in human and mouse brains,[3] as well as in embryonic stem cells.[4] In mammals, it can be generated by oxidation of 5-methylcytosine, a reaction mediated by the Tet family of enzymes. 5-Hydroxymethylcytidine is a product in DNA hydroxymethylation. The concentrations of 5-Hydroxymethylcytidine in the brain were used to study Alzheimers disease. Group: Biochemicals. Grades: Highly Purified. CAS No. 19235-17-7. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
7-Azido-4-methylcoumarin (AzMC) Quick inquiry Where to buy Suppliers range | Highly sensitive and selective fluorogenic H2S probe. The aromatic azide moiety of AzMC is selectively reduced in the presence of H2S, producing the fluorescent 7-amino-4- methylcoumarin (AMC) with a concomitant increase in fluorescence with lambdaex=365nm and lambdaem=450nm. Photoaffinity labeling probe for the substrate binding site of human sulfotransferase 1A1 (SULT1A1). Probe to monitor the enzymatic production of H2S in vitro and to visualize H2S in living cells. Tool for monitoring the activity of pyridoxal-5'-phosphate (PLP)-dependent enzymes (e.g. cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CGL) and tryptophan synthase (TS)). Tool to identify novel cystathionine beta-synthase (CBS) inhibitors and activators. Suitable for high-throughput screening. Use of this product with DTT, TCEP and/or biological thiols at concentrations of >25mM should be avoided for maximum efficiency. Group: Biochemicals. Grades: Highly Purified. CAS No. 95633-27-5. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
8-[(6-Amino)hexyl]-amino-GTP - Biotin Quick inquiry Where to buy Suppliers range | 8-[(6-Amino)hexyl]-amino-GTP - Biotin, a biochemical product, finds its application in exploring cell signaling pathways and G protein-coupled receptor (GPCR) signaling. Besides working as a probe for GTPases, it serves as a substrate for enzymatic assays to track G-protein activation or GTP concentration in cells. Also, it is a famous material for affinity purification, allowing researchers to isolate target proteins during chromatography. Overall, this versatile compound amplifies the scope of cell biology-related inquiries in both academia and industry. Synonyms: 8-[(6-Amino)hexyl]-amino-guanosine-5'-triphosphate - Biotin, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C26H44N9O16P3S (free acid). Mole weight: 863.66 (free acid). | |
A-740003 Quick inquiry Where to buy Suppliers range | A-740003 is potent, selective and competitive P2X7 receptor antagonist. Its IC50 values are 18 and 40 nM for rat and human receptors respectively measured by agonist-stimulated changes in intracellular calcium concentrations. It displays selectivity over a variety of P2X and P2Y receptors up to a concentration of 100 μM. It reduces nociception in animal models of persistent neuropathic and inflammatory pain. It showed weak or no activity (IC(50) > 10 muM) at other P2 receptors and an array of other neurotransmitter and peptide receptors, ion channels, reuptake sites, and enzymes. It potently blocked agonist-evoked IL-1beta release (IC(50) = 156 nM) and pore formation (IC(50) = 92 nM) in differentiated human THP-1 cells. It produces significant antinociception in animal models of neuropathic and inflammatory pain in vivo. Uses: A-740003 produces significant antinociception in animal models of neuropathic and inflammatory pain in vivo. Synonyms: A-740003; A 740003; A740003; N-[1-[[(Cyanoamino)(5-quinolinylimino)methyl]amino]-2,2-dimethylpropyl]-3,4-dimethoxybenzeneacetamide;N-(1-{[(cyanoimino)(5-quinolinylamino) methyl] amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide. Grades: >98 %. CAS No. 861393-28-4. Molecular formula: C26H30N6O3. Mole weight: 474.55. | |
Alectinib Quick inquiry Where to buy Suppliers range | Alectinib, marketed as Alecensa, is an oral drug that blocks the activity of anaplastic lymphoma kinase (ALK) and is used to treat non-small-cell lung cancer (NSCLC). Alectinib has a low potential for interactions. While it is metabolised by the liver enzyme CYP3A4, and blockers of this enzyme accordingly increase its concentrations in the body, they also decrease concentrations of the active metabolite M4, resulting in only a small overall effect. Conversely, CYP3A4 inducers decrease alectinib concentrations and increase M4 concentrations. Interactions via other CYP enzymes and transporter proteins cannot be excluded but are unlikely to be of clinical significance. Synonyms: CH-5424802; CH5424802; CH 5424802; AF-802; RG-7853; RO5424802. Grades: ≥95%. CAS No. 1256580-46-7. Molecular formula: C30H34N4O2. Mole weight: 482.62. | |
Alginic acid sodium salt, Biochemical grade, suitable for fixing cells, enzymes, etc. Quick inquiry Where to buy Suppliers range | Sodium alginate is a linear polymer extracted from brown algae or Sargasso organic solvents such as ether. Sodium alginate dissolves in water to form a viscous colloid. After absorbing water, its volume can increase by 10 times its original volume. The viscosity of its aqueous solution varies mainly with the degree of polymerization and concentration. Sodium alginate is more stable in dry powder state than in solution state. As a natural polymer hydrosol, sodium alginate has many characteristics such as good water solubility, non-toxicity, easy degradation and good biocompatibility, and has a good synergistic effect with other colloids. Therefore, it has huge application value in various industries such as medicine, food, packaging, textile industry, and biological materials. Uses: ·Stabilizer, thickener, as artificial semipermeable membrane, mordant ·Fixed cells, enzymes ·Suitable for gel-based separation techniques ·Preparation of colloidal biodegradable structures. Group: Plant Hydrocolloids. CAS No. 9005-38-3. Density: Slowly soluble in water forming a viscous, colloidal solution, practically insoluble in ethanol (96 per cent). | |
Altenusin Quick inquiry Where to buy Suppliers range | Altenusin is a a biphenyl derivative with an IC50 value of 4.3±0.3 μM in the TR assay, which is isolated from the endophytic fungus Alternaria. It inhibits Src kinase with an IC50 value of 20 nM. Altenusin inhibits fibrillization of recombinant tau fragments in vitro and phosphorylation of tau in SH-SY5Y cells expressing human P301L mutant tau when used at a concentration of 10 μM. Altenusin is known to have antioxidant properties and to inhibit several enzymes, including myosin light chain kinase, sphingomyelinase, acetylcholinesterase, cFMS kinase, pp60c-SRc kinase and HIV-1 integrase. Synonyms: Alutenusin; MS 341; MS-341; MS341. Grades: ≥98%. CAS No. 31186-12-6. Molecular formula: C15H14O6. Mole weight: 290.27. | |
Aminooxyacetic Acid Quick inquiry Where to buy Suppliers range | Aminooxyacetic acid, often abbreviated AOA or AOAA, is a GABA transaminase (GABA-T) inhibitor (Ki = 9.16 μM) that inhibits 4-aminobutyrate aminotransferase (GABA-T) activity in vitro and in vivo, leading to less gamma-aminobutyric acid (GABA) being broken down. Subsequently, the level of GABA is increased in tissues. At concentrations high enough to fully inhibit 4-aminobutyrate aminotransferase activity, aminooxyacetic acid is indicated as a useful tool to study regional GABA turnover in rats. AOAA is also an inhibitor of pyridoxal phosphate (PLP)-dependent enzymes, which serve as an inhibitor by attacking the Schiff base linkage between PLP and the enzyme, forming oxime type complexes. Uses: Gaba agents. Synonyms: Aminooxyacetate; AOAA; 2-Aminooxyacetic acid; U 7524; U7524; U-7524. Grades: ≥95%. CAS No. 645-88-5. Molecular formula: C2H5NO3. Mole weight: 91.07. | |
Aminopeptidase N Inhibitor Quick inquiry Where to buy Suppliers range | Membrane alanyl aminopeptidase is also known as alanyl aminopeptidase (AAP) or aminopeptidase N (AP-N), which is an enzyme that in humans is encoded by the ANPEP gene. Aminopeptidase N (AP-N) inhibitor is a reversible inhibitor of AP-N/CD13 (IC50 = 25 μM). It is selective for AP-N/CD13 over matrix metalloproteinase-9 (MMP-9), angiotensin converting enzyme (ACE), neutral endopeptidase (NEP), γ-glutamyl transpeptidase, and the serine proteases dipeptidyl peptidase 4 (DPP-4) and cathepsin G at a concentration of 1 mM. AP-N inhibitor is non-cytotoxic to U937 cells at a concentration of 100 μM. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. Synonyms: AP-N Inhibitor. Grades: ≥95%. CAS No. 596108-59-7. Molecular formula: C17H10N2O8. Mole weight: 370.27. | |
Aprotinin, Bovine (Pancreatic trypsin inhibitor) Quick inquiry Where to buy Suppliers range | Aprotinin is a competitive serine protease inhibitor that inhibits trypsin, chymotrypsin, kallikrein and plasmin. Aprotinin forms stable complexes with and blocks the active sites of enzymes. Binding is reversible with most aprotinin-protease complexes, dissociating at pH >10 or <3. Effective concentration is equimolar with protease. Group: Biochemicals. Alternative Names: Antikrein; Antilysin; Antilysine; Aprostat; Aprotinin; BPTI; BPTI Trypsin Inhibitor; Basic Pancreatic Trypsin Inhibitor; Bayer A 128; Bovine Basic Pancreatic Trypsin Inhibitor; Bovine Pancreatic Trypsin Inhibitor; Bovine Trypsin Inhibitor; Fosten; Kallikrein-trypsin Inactivator; Kiker 52G; Kir Richter; Kunitz Pancreatic Trypsin Inhibitor; Kunitz Protease Inhibitor; Kunitz Trypsin Inhibitor; Kunitz-type Inhibitor; Kunitz-type Proteinase Inhibitor; Kunitz-type Trypsin Inhibitor; Onquinin; Pancreatic Basic Trypsin Inhibitor; Pancreatic Trypsin Inhibitor; Pancreatic Trypsin Inhibitor (Kunitz); Protease Inhibitor, Kunitz Type; RP 9921; Repulson; Trasuylol; Trasylol; Trazinin; Triazinin; Trypsin Inhibitor, Trasylol; Trypsin-kallikrein Inhibitor (Kunitz); Zymofren. Grades: Highly Purified. CAS No. 9087-70-1. Pack Sizes: 100mg, 250mg, 500mg, 1g. Molecular Formula: C???H???N??O??S?, Molecular Weight: 6511.45. US Biological Life Sciences. | Worldwide |
Aranorosin Quick inquiry Where to buy Suppliers range | Aranorosin is a fungal metabolite originally isolated from P. roseus and an inhibitor of anti-apoptotic functions regulated by Bcl-2. It has antimicrobial activity against B. subtilis, A. niger, and C. albicans when used at a concentration of 1 mg/ml. Aranorosin also reduces viability in apoptosis-resistant HeLa/Bcl-2 cells. Aranorosin also inhibits enzyme AAC(6')/APH(2'') which plays a role in arbekacin (ABK)-resistance in MRSA. Synonyms: Spiro[4,8-dioxatricyclo[5.1.0.03,5]octane-2,2'(3'H)-furan], 2,4-dodecadienamide deriv.; Aranorosine. Grades: ≥95%. CAS No. 117184-53-9. Molecular formula: C23H33NO6. Mole weight: 419.51. | |
AS1940477 Quick inquiry Where to buy Suppliers range | AS1940477 is p38 MAPK inhibitor. AS1940477 inhibited the enzymatic activity of recombinant p38α and β isoforms but showed no effect against other 100 protein kinases including p38γ and δ isoforms. In human peripheral blood mononuclear cells, AS1940477 inhibited lipopolysaccharide (LPS)- or phytohemagglutinin A (PHA)-induced production of proinflammatory cytokines, including TNFα, IL-1β, and IL-6 at low concentrations (LPS/TNFα, IC(50)=0.45n M; PHA/TNFα, IC(50)=0.40 nM). In addition, equivalent concentrations of AS1940477 that inhibited cytokine production also inhibited TNFα- and IL-1 β-induced production of IL-6, PGE(2), and MMP-3 in human synovial stromal cells. AS1940477 was also found to potently inhibit TNF production in whole blood (IC(50)=12 nM) and effectively inhibited TNFα production induced by systemically administered LPS in rats at less than 0.1mg/kg (ED(50)=0.053 mg/kg) with an anti-inflammatory effect lasting for 20h after oral administration. Overall, this study demonstrated that AS1940477 is a novel and potent p38 MAPK inhibitor and may be useful as a promising anti-inflammatory agent for treating inflammatory disorders. Synonyms: AS1940477; AS-1940477; AS 1940477. CAS No. 928344-12-1. Molecular formula: C24H22FN5O2. Mole weight: 431.47. | |
ASPARTATE TRANSAMINASE (AST) (catalytic activity concentration Quick inquiry Where to buy Suppliers range | ASPARTATE TRANSAMINASE (AST) (catalytic activity concentration. Uses: For analytical and research use. Group: Enzyme Activators, Inhibitors & Substrates. Catalog: APS005835. Format: Neat. Shipping: Dry ice. | |
Atazanavir Quick inquiry Where to buy Suppliers range | Atazanavir is a novel and potent azapeptide protease inhibitor that specifically inhibits the human immunodeficiency virus type 1 (HIV-1) protease enzyme with inhibition constant Ki of 66 nmol/L and also inhibits the viral replication of HIV-1 with 50% effective concentration EC50 ranging from 2.6 to 5.3 nmol/L. Atazanavir binds to HIV-1 protease preventing the cleavage of gag and gag-pol polyproteins, which results in the formation of immature virions in HIV-1-infected cells. Atazanavir has a different C-2 symmetric chemical structure and a generally greater antiretroviral potency in various HIV strains compared to other protease inhibitors, including indinavir, nelfinavir, ritonavir, saquinavir and amprenavir. Synonyms: Atazanavir ; Reyataz ; Atazanavir sulfate ; CGP75136 ; CGP75176 ; CGP75355 ; BMS232632 ; CGP 73547 ; CGP 75136 ; CGP 75176 ; CGP 75355 ; CGP-73547 ; CGP-75136 ; CGP-75176 ; CGP-75355 ; BMS 232632 ; BMS-232632 ; BMS-232632-05 ; C413408. Grades: 0.98. CAS No. 198904-31-3. Molecular formula: C38H52N6O7. Mole weight: 704.869. | |
Aureobasidin A Quick inquiry Where to buy Suppliers range | Aureobasidin A is an orally available cyclic depsipeptide antibiotic produced by Aureobasidium pullulans that is a fungicide at low concentrations. Aureobasidin A inhibits inositol phosphorylceramide synthase, an enzyme that catalyzes a key step in fungal sphingolipid biosynthesis. This may inhibit fungal cell growth. Uses: Microbial Fermentation Products. CAS No. 127785-64-2. Product ID: MFP-034. | |
AZ0108 Quick inquiry Where to buy Suppliers range | AZ0108 is an orally bioavailable, PARP1,2,6 inhibitor that causes a multi-polar spindle phenotype at double digit nM concentrations. AZ0108 has been utilized as in vitro tools and in vivo probes to investigate the biological consequences of inhibiting centrosome clustering through PARP enzymes. Synonyms: (S) -4- ( (3- (3- (1, 1-difluoroethyl) -6-methyl-5, 6, 7, 8-tetrahydro-[1, 2, 4]triazolo[4, 3-a]pyrazine-7-carbonyl) phenyl) difluoromethyl) phthalazin-1 (2H) -one; AZ0108; AZ-0108; AZ 0108. Grades: >98%. CAS No. 1825345-52-5. Molecular formula: C24H20F4N6O2. Mole weight: 500.45. | |
Bromoenol lactone Quick inquiry Where to buy Suppliers range | BEL is a selective, potent, irreversible, mechanism-based inhibitor of myocardial cytosolic calcium-independent phospholipase A2 (iPLA2) with a Ki value of 180 nM. BEL induces the proteolysis of procaspase-9 and procaspase-3 and increases cleavage of poly (ADP-ribose) polymerase. BEL also inhibits macrophage iPLA2 in a concentration-dependent manner with an IC50 value of 60 nM and is an effective enzyme-activated irreversible inhibitor of chymotrypsin Ki of 636 nM. Long term treatment with BEL increased annexin-V binding to the cell surface and nuclear DNA damage. Synonyms: BEL; Haloenol lactone; HELSS. Grades: ≥95%. CAS No. 88070-98-8. Molecular formula: C16H13BrO2. Mole weight: 317.2. | |
C3bot (154-182) Quick inquiry Where to buy Suppliers range | C3bot (154-182) is a transferase-deficient neurotrophic fragment of clostridial C3 protein. It promotes axonal and dendritic growth and branching of hippocampal neurons at submicromolar concentrations and promotes reinnervation of target tissues in organotypical hippocampal/entorhinal slice cultures. It reduces levels of active neuronal RhoA by a non-enzymatic mechanism and enhances functional recovery and regeneration in a mouse model of spinal cord injury. Synonyms: C3bot (154-182); 1246280-79-4. CAS No. 1246280-79-4. Molecular formula: C137H221N37O40S. Mole weight: 3058.54. | |
Catalase, Laboratory Grade, 1 mL Quick inquiry Where to buy Suppliers range | Dilute 1 mL catalase to 715 mL with distilled water for a final concentration of 400 IU/mL; converts hydrogen peroxide to oxygen and water; keep refrigerated; oxidizing enzyme. This product has a shelf life of 6 months from date of receipt. Health Risk: 1. Flammability: 1. Reactivity: 0. Grades: chem-grade laboratory. CAS No. 9001-5-2. Product ID: 853530. -- SOLD FOR EDUCATIONAL USE ONLY -- | |
Catalase, Laboratory Grade, 5 mL Quick inquiry Where to buy Suppliers range | Dilute 1 mL catalase to 715 mL with distilled water for a final concentration of 400 IU/mL; converts hydrogen peroxide to oxygen and water; keep refrigerated; oxidizing enzyme. This product has a shelf life of 6 months from date of receipt. Health Risk: 1. Flammability: 1. Reactivity: 0. Grades: chem-grade laboratory. CAS No. 9001-5-2. Product ID: 853532. -- SOLD FOR EDUCATIONAL USE ONLY -- | |
CEP-14083 Quick inquiry Where to buy Suppliers range | CEP-14083 is a ALK inhibitor. It has a potent activity against ALK in enzymatic assays (IC50 = 11 nmol/L). CEP-14083 can also inhibit the insulin receptor at a concentration within a nanomolar range. In a preclinical assay, CEP-14083 showed it can control the expression of molecules that determine T-cell identity and signaling in lymphoma cells. Synonyms: CEP14083; CEP 14083; CEP-14083. 1-methyl-3-(4-methyl-6-oxo-13-propyl-2,4,6,7,8,13-hexahydro-1H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-10-yl)-1-phenylurea. Grades: 98%. CAS No. 856692-39-2. Molecular formula: C31H30N6O2. Mole weight: 518.61. | |
CJ-42794 Quick inquiry Where to buy Suppliers range | CJ-42794 is a selective prostaglandin E receptor subtype 4 (EP4) antagonist. It inhibits [3H]-PGE2 binding to the human EP4 receptor with a mean pKi of 8.5. It competitively antagonized cAMP accumulation with a pA2 value of 8.7 in HEK293 cells overexpressing rat prostanoid EP4 receptors. It did not exhibit any remarkable binding to 65 additional proteins, including GPCRs, enzymes, and ion channels. It reversed the inhibitory effects of PGE2 on LPS-induced TNFα production in a concentration-dependent manner. It has excellent pharmacological properties that make it a useful tool for exploring the physiological role of EP4 receptors. Uses: Cj-42794 has excellent pharmacological properties that make it a useful tool for exploring the physiological role of ep4 receptors. Synonyms: CJ-042794; CJ 042794; CJ042794; RQ-00015986, RQ-15986. 4-[ (1S) -1-[[5-chloro-2- (4-fluorophenoxy) benzoyl]amino]ethyl]benzoic acid; (S) -4- (1- (5-chloro-2- (4-fluorophenoxy) benzaMido) ethyl) benzoic acid;CJ-042794;4-((S)-1-(2-(4-fluorophenoxy)-5-chlorobenzamido)ethyl)benzoic acid. Grades: >98%. CAS No. 847728-01-2. Molecular formula: C22H17ClFNO4. Mole weight: 413.83. | |
Collagen Protein, Hydrolyzed Quick inquiry Where to buy Suppliers range | Unique collagen protein concentrate. Manufactured via an enzymatic hydrolysis process, mixture of straight chain polypeptide with an average molecular weight of 2,000 (range 14 KDa). Animal derived (bovine). Uses: Anti-aging and moisturizing lotions, creams, serums, sun care & after sun products, makeup products, hair conditioners, hair shampoos, hair masks. Group: Cationic Surfactants & Conditioning Agents. CAS No. 92113-31-0. Product ID: ACM92113310-1. Appearance: Off-white powder, faint odor. | |
Cytochlor Quick inquiry Where to buy Suppliers range | Cytochlor is a radio-sensitizing pyrimidine nucleoside with potential antineoplastic activity. Cytochlor is metabolized first to a phosphate derivative, CldCMP, by the enzyme deoxycytidine kinase and then to the active uracyl derivative, CldUMP, by the enzyme dCMP deaminase; deoxycytidine kinase and dCMP deaminase have been found in abnormally high concentrations in most cancers. CldUMP, the active metabolite, incorporates into DNA and, upon exposure to radiation, induces the formation of uracil radicals and double-strand DNA breaks. Synonyms: 5-Chloro-2'-deoxycytidine; 5-Chlorodeoxycytidine; 2'-Deoxy-5-chlorocytidine; NSC-371331; NSC 371331. Grades: ≥ 97%. CAS No. 32387-56-7. Molecular formula: C9H12ClN3O5. Mole weight: 261.66. | |
D-Eritadenine Quick inquiry Where to buy Suppliers range | D-Eritadenine is an adenosine analog and a potent, reversible inhibitor of S-adenosylhomocysteine hydrolase. Dietary administration of D-eritadenine (50 mg/kg) increases liver microsomal phosphatidylethanolamine concentration and decreases liver microsomal Δ6 desaturase activity and plasma cholesterol levels in rats. Uses: Enzyme inhibitors. Synonyms: (αR,βR)-6-Amino-α,β-dihydroxy-9H-purine-9-butanoic Acid; 4-(6-Amino-9H-purin-9-yl)-4-deoxy-D-erythronic Acid; 4-(6-Aminopurin-9-yl)-4-deoxy-D-erythronic Acid; Lentinacin; Lentysine; 4-(9-Adenyl)-D-erythro-2,3-dihydroxybutyric Acid; Eritadenine; Lentysine; Lentinacin. Grades: ≥95%. CAS No. 23918-98-1. Molecular formula: C9H11N5O4. Mole weight: 253.21. | |
DMBO (CCDC-272761) Quick inquiry Where to buy Suppliers range | An oxazine that appears to mimic the pyranosidic moiety of heparin sulfate, and is shown to interact directly with several growth factors and cytokines including VEGF, TNF-a and heparin-binding-EGF in a surface plasmon resonance assay. At concentrations of 10-80uM, this compound dose-dependently inhibits the proliferation of VEGF-expressing LM8G7 cells (IC50=13uM), and TNF-a-expressing OVSAHO cells (IC50=19uM). At 195uM, a 99% reduction in cell growth is observed in HB-EGF-expressing SKOV-3 cultures. This compound inhibits heparanase-mediated degradation of heparin sulfate in LM8G7 cells (IC50=65uM and 104-206uM, in an enzymatic and a cell based assay, respectively). At 0.5-5uM, it markedly prevents the migration and invasion of the same culture, in a dose-dependent manner. In addition, it completely suppresses liver metastatic nodules of osteosarcoma mice injected with LM8G7 cells at 0.5mg/kg without any signs of toxicity in vivo, and demonstrates a synergistic anti-tumor effect when Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
EDA-ADP - ATTO-565 Quick inquiry Where to buy Suppliers range | EDA-ADP-ATTO-565, an indispensable fluorescent compound employed in biomedical research, plays a key role in discerning and tracking the ADP concentrations in vivo. Owing to its high specificity, it is capable of effectively classifying and measuring the enzymatic activity responsible for ADP metabolism, thereby propelling the breakthrough discoveries of therapeutic cures targeting fatal cardiovascular ailments like stroke, heart attack, and thrombosis. Synonyms: 2'/3'-O-(2-Aminoethyl-carbamoyl)-Adenosine-5'-diphosphate, labeled with ATTO 565, Triethylammonium salt. Grades: ≥ 95 % by HPLC. Molecular formula: C44H49N9O15P2(free acid). Mole weight: 1005.87 (free acid). | |
Elacridar Quick inquiry Where to buy Suppliers range | Elacridar hydrochloride (GF120918A) is a P-glycoprotein inhibitor, and has been used both in vitro and in vivo as a tool inhibitor of P-glycoprotein (Pgp) to investigate the role of transporters in the disposition of various test molecules. In vitro, GF120918A demonstrated high plasma protein binding across species, although a definitive protein binding evaluation was precluded by poor recovery, particularly in buffer and in mouse, rat, and dog plasma. GF120918A did not demonstrate potent inhibition of several human cytochrome P450 enzymes evaluated in vitro, with IC(50) values well above concentrations anticipated to be achieved in vivo. Together, these data confirm the utility of GF120918A as a tool P-glycoprotein inhibitor in preclinical species and offer additional guidance on preclinical dose regimens likely to produce P-glycoprotein-mediated effects. Synonyms: GF120918; GF-120918; GF 120918; GF-120918A; GF120918A; GF 120918A; GG 918; D03968. Elacridar hydrochloride. CAS No. 143664-11-3. Molecular formula: C34H33N3O5. Mole weight: 563.654. | |
Ethonafide Quick inquiry Where to buy Suppliers range | Ethonafide is an anthracene-containing derivative of amonafide that belongs to the azonafide series of anticancer agents. The lack of cross-resistance in multidrug-resistant cancer cell lines and the absence of a quinone and hydroquinone moiety make ethonafide a potentially less cardiotoxic replacement for existing anthracene-containing anticancer agents. Ethonafide was cytotoxic against three human prostate cancer cell lines at nanomolar concentrations. Ethonafide was found to be better tolerated and more effective at inhibiting tumor growth compared with mitoxantrone in a human xenograft tumor regression mouse model. Mechanistically, we found that ethonafide inhibited topoisomerase II activity by stabilizing the enzyme-DNA complex, involving both topoisomerase IIalpha and -beta. In addition, ethonafide induced a potent G(2) cell cycle arrest in the DU 145 human prostate cancer cell line. By creating stable cell lines with decreased expression of topoisomerase IIalpha or -beta, we found that a decrease in topoisomerase IIalpha protein expression renders the cell line resistant to ethonafide. The decrease in sensitivity to ethonafide was associated with a decrease in DNA damage and an increase in DNA repair as measured by the neutral comet assay. These data demonstrate that ethonafide is a topoisomerase II poison and that it is topoisomerase IIalpha-specific in the DU 145 human prostate cancer cell line. Uses: Topoisomerase ii inhibitors. Synonyms: AMP-53; AMP 53; AMP53; 2-(2'-(Dimethylamino)ethyl)-1,2-dihydro-7-ethoxydibenz(de, H)isoquinoline-1,3-dione; 2-[2-(Dimethylamino)ethyl]-7-ethoxy-1H-dibenz[de,h]isoquinoline-1,3(2H)-dione. CAS No. 175293-23-9. Molecular formula: C22H22N2O3. Mole weight: 362.43. | |
Frenatin 3 Quick inquiry Where to buy Suppliers range | Frenatin 3 inhibits the production of nitric oxide by the enzyme neuronal nitric oxide synthase at a micromolar concentration by binding to its regulatory protein, Ca2+ calmodulin, a protein known to recognize and bind amphipathic alpha-helices. Grades: >95% by HPLC. Molecular formula: C88H146N24O24S. Mole weight: 1956.31. | |
γ-[(6-Aminohexyl)imido]-ATP - Texas Red Quick inquiry Where to buy Suppliers range | γ-[(6-Aminohexyl)imido]-ATP - Texas Red is a fluorescent ATP analogue used as a research tool to visualize and measure cellular ATP concentrations in real time. It has also been utilized in studies to investigate cellular energy metabolism and enzyme kinetics, as well as neuronal signaling pathways. Synonyms: γ-[(6-Aminohexyl)-imido]-adenosine-5'-triphosphate, labeled with Texas Red, Triethylammonium salt. Grades: ≥ 95 % by HPLC. Molecular formula: C53H69N10O19P3S2(free acid). Mole weight: 1306.34 (free acid). | |
GIRK Activator, ML297 (1-(3,4-Difluorophenyl)-3-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea, N-(3,4-Difluorophenyl)-N?-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea, CID 56642816, VU0456810) Quick inquiry Where to buy Suppliers range | A blood-brain barrier-permeable, non-toxic phenyl-pyrazolylurea compound that acts as a direct, potent, fast, and reversible activator of GIRK1 (G-protein activated inward-rectifying K+ channel containing subunit 1) containing channels (EC50 = 162, 914, and 887nM in Thallium influx assay for GIRK1/2, GIRK1/3, and GIRK1/4 expressed in HEK-293 cell lines). Its action does not require the presence of an activated Gi GPCR. Shown to be inactive towards GIRK2, GIRK2/3, Kir2.1, KV7.4 and GABAA, and weakly active against a panel of 61 other receptors, ion channels, enzymes, transporters, and proteins even at higher concentration (~10uM). Exhibits desirable pharmacokinetic properties with good solubility (17.5uM), predicted hepatic clearance (88 ml/min/kg), and Tmax of 640nM and 130nM in plasma and brain, respectively. Shown to reduce locomotor function and seizure frequency in electroshock- and chemically-induced murine epilepsy models (60mg/kg, i.p). Group: Biochemicals. Grades: Highly Purified. CAS No. 1443246-62-5. Pack Sizes: 10mg. Molecular Formula: C??H??F?N?O. US Biological Life Sciences. | Worldwide |
GPI-15427 Quick inquiry Where to buy Suppliers range | GPI-15427 is a potent PARP-1 inhibitor capable of crossing the blood-brain barrier, which can significantly increased the antitumor activity of the methylating agent TMZ against malignant melanoma, glioblastoma multiforme, or lymphoma growing at the CNS site. GPI-15427 acts as a potent inhibitor of the enzyme, being capable of inhibiting the activity of purified PARP-1 at nanomolar concentrations. GPI-15427 induced significant sensitization to radiotherapy, representing a promising new treatment in the management of HNSCC. Uses: Poly(adp-ribose) polymerase inhibitors. Synonyms: GPI 15427; GPI15427; 10-((4-Methylpiperazin-1-yl)methyl)chromeno(4,3,2-de)phthalazin-3(2H)-one. CAS No. 805242-85-7. Molecular formula: C20H20N4O2. Mole weight: 348.41. | |
GSK 962040 Quick inquiry Where to buy Suppliers range | GSK 962040 is a selective motilin receptor agonist with pEC50 value of 7.9. It is effective as a stimulant of human and rabbit gastrointestinal motility. lt represents a new opportunity as a treatment in diabetic gastroparesis. It is discovered as a therapeutic agent for conditions associated with delayed gastric emptying. It is highly selective against motilin receptor over the human ghrelin receptor and hERG. It also has no significant activity against other receptors including 5-HT, adrenergic, dopamine, histamine and adenosine receptors. It is found to enhance the EFS-induced cholinergic contraction and cause a small muscle contraction at high concentration in rabbit isolated gastric antrum. It also induces the contraction of human-isolated stomach preparations at 10μM. It had no significant activity at a range of other receptors (including ghrelin), ion channels and enzymes in vitro. It was preferred because its initial IC50 values at CYP3A4 were significantly higher than our preferred threshold of 10 μM. It induced phasic contractions, the duration of which was dose-related. It strongly facilitated cholinergic activity in the antrum, with lower activity in fundus and small intestine only. It was developed by glaxosmithkline and has been in Cilinic Phase 2. Uses: Gsk 962040 may be used as a treatment in diabetic gastroparesis. Synonyms: GSK-962040; GSK 962040; GSK962040; Camicinal;1-[4-(3-fluoroanilino)piperidin-1-yl]-2-[4-[[(3S)-3-methylpiperazin-1-yl]methyl]phenyl]ethanone. Grades: >98%. CAS No. 923565-21-3. Molecular formula: C25H33FN4O. Mole weight: 424.55. | |
Gum Arabic, Analytical reagent Quick inquiry Where to buy Suppliers range | Gum arabic (GA) is a mixture of polysaccharides and glycoproteins (GP) with properties of glue and adhesive. Gum arabic readily dissolves in water, forming a clear solution ranging in color from very pale yellow to orange-brown at a pH of about 4.5. GA is used as an emulsifier and thickener in icings, fillings, chewing gum and other confections. GA was more effective in inhibiting non-enzymatic browning and as a color preservative in dehydrated tomatoes. The addition of GA significantly improved the color stability of anthocyanins; the efficacy decreased with increasing concentrations due to changes in the conformation of the gum molecules that hindered their contact with anthocyanins. Gum arabic was found to be an excellent color preservative and inhibitor of non-enzymatic browning of dehydrated tomatoes during storage. Uses: ·Food industry: (1) role of protective colloid or stabilizer; (2) adhesiveness of aqueous solution; (3) thickening ·Medicine: Gum arabic is mainly used as a suspending and emulsifying agent in oral and topical pharmaceutical preparations ·Printing industry: for wiping printing layouts ·Adhesives: used for bonding paper, wood, ceramics, glass, etc. Group: Plant Hydrocolloids. CAS No. 9000-1-5. Purity: 1.35 g/mL. Density: Water soluble. Aqueous solution is acidic to litmus. | |
gum arabic derived from black locust, branched polysaccharide Quick inquiry Where to buy Suppliers range | Gum arabic (GA) is a mixture of polysaccharides and glycoproteins (GP) with properties of glue and adhesive. Gum arabic readily dissolves in water, forming a clear solution ranging in color from very pale yellow to orange-brown at a pH of about 4.5. GA is used as an emulsifier and thickener in icings, fillings, chewing gum and other confections. GA was more effective in inhibiting non-enzymatic browning and as a color preservative in dehydrated tomatoes. The addition of GA significantly improved the color stability of anthocyanins; the efficacy decreased with increasing concentrations due to changes in the conformation of the gum molecules that hindered their contact with anthocyanins. Gum arabic was found to be an excellent color preservative and inhibitor of non-enzymatic browning of dehydrated tomatoes during storage. Uses: ·Food industry: (1) role of protective colloid or stabilizer; (2) adhesiveness of aqueous solution; (3) thickening ·Medicine: Gum arabic is mainly used as a suspending and emulsifying agent in oral and topical pharmaceutical preparations ·Printing industry: for wiping printing layouts ·Adhesives: used for bonding paper, wood, ceramics, glass, etc. Group: Plant Hydrocolloids. CAS No. 9000-1-5. Purity: 1.35 g/mL. Density: Water soluble. Aqueous solution is acidic to litmus. | |
Gum arabic derived from locust, Reagent grade Quick inquiry Where to buy Suppliers range | Gum arabic (GA) is a mixture of polysaccharides and glycoproteins (GP) with properties of glue and adhesive. Gum arabic readily dissolves in water, forming a clear solution ranging in color from very pale yellow to orange-brown at a pH of about 4.5. GA is used as an emulsifier and thickener in icings, fillings, chewing gum and other confections. GA was more effective in inhibiting non-enzymatic browning and as a color preservative in dehydrated tomatoes. The addition of GA significantly improved the color stability of anthocyanins; the efficacy decreased with increasing concentrations due to changes in the conformation of the gum molecules that hindered their contact with anthocyanins. Gum arabic was found to be an excellent color preservative and inhibitor of non-enzymatic browning of dehydrated tomatoes during storage. Uses: ·Food industry: (1) role of protective colloid or stabilizer; (2) adhesiveness of aqueous solution; (3) thickening ·Medicine: Gum arabic is mainly used as a suspending and emulsifying agent in oral and topical pharmaceutical preparations ·Printing industry: for wiping printing layouts ·Adhesives: used for bonding paper, wood, ceramics, glass, etc. Group: Plant Hydrocolloids. CAS No. 9000-1-5. Purity: 1.35 g/mL. Density: Water: soluble. | |
Gum arabic derived from locust, spray dried Quick inquiry Where to buy Suppliers range | Gum arabic (GA) is a mixture of polysaccharides and glycoproteins (GP) with properties of glue and adhesive. Gum arabic readily dissolves in water, forming a clear solution ranging in color from very pale yellow to orange-brown at a pH of about 4.5. GA is used as an emulsifier and thickener in icings, fillings, chewing gum and other confections. GA was more effective in inhibiting non-enzymatic browning and as a color preservative in dehydrated tomatoes. The addition of GA significantly improved the color stability of anthocyanins; the efficacy decreased with increasing concentrations due to changes in the conformation of the gum molecules that hindered their contact with anthocyanins. Gum arabic was found to be an excellent color preservative and inhibitor of non-enzymatic browning of dehydrated tomatoes during storage. Uses: ·Food industry: (1) role of protective colloid or stabilizer; (2) adhesiveness of aqueous solution; (3) thickening ·Medicine: Gum arabic is mainly used as a suspending and emulsifying agent in oral and topical pharmaceutical preparations ·Printing industry: for wiping printing layouts ·Adhesives: used for bonding paper, wood, ceramics, glass, etc. Group: Plant Hydrocolloids. CAS No. 9000-1-5. Purity: 1.35 g/mL. Density: Water: soluble. | |
Gum arabic derived from locust, spray dried, loss : ≤10 % loss on drying Quick inquiry Where to buy Suppliers range | Gum arabic (GA) is a mixture of polysaccharides and glycoproteins (GP) with properties of glue and adhesive. Gum arabic readily dissolves in water, forming a clear solution ranging in color from very pale yellow to orange-brown at a pH of about 4.5. GA is used as an emulsifier and thickener in icings, fillings, chewing gum and other confections. GA was more effective in inhibiting non-enzymatic browning and as a color preservative in dehydrated tomatoes. The addition of GA significantly improved the color stability of anthocyanins; the efficacy decreased with increasing concentrations due to changes in the conformation of the gum molecules that hindered their contact with anthocyanins. Gum arabic was found to be an excellent color preservative and inhibitor of non-enzymatic browning of dehydrated tomatoes during storage. Uses: ·Food industry: (1) role of protective colloid or stabilizer; (2) adhesiveness of aqueous solution; (3) thickening ·Medicine: Gum arabic is mainly used as a suspending and emulsifying agent in oral and topical pharmaceutical preparations ·Printing industry: for wiping printing layouts ·Adhesives: used for bonding paper, wood, ceramics, glass, etc. Group: Plant Hydrocolloids. CAS No. 9000-1-5. Purity: 1.35 g/mL. Density: Water soluble. Aqueous solution is acidic to litmus. | |
Gum Arabic, Granular, Hand selected fine, Light yellow Quick inquiry Where to buy Suppliers range | Gum arabic (GA) is a mixture of polysaccharides and glycoproteins (GP) with properties of glue and adhesive. Gum arabic readily dissolves in water, forming a clear solution ranging in color from very pale yellow to orange-brown at a pH of about 4.5. GA is used as an emulsifier and thickener in icings, fillings, chewing gum and other confections. GA was more effective in inhibiting non-enzymatic browning and as a color preservative in dehydrated tomatoes. The addition of GA significantly improved the color stability of anthocyanins; the efficacy decreased with increasing concentrations due to changes in the conformation of the gum molecules that hindered their contact with anthocyanins. Gum arabic was found to be an excellent color preservative and inhibitor of non-enzymatic browning of dehydrated tomatoes during storage. Uses: ·Food industry: (1) role of protective colloid or stabilizer; (2) adhesiveness of aqueous solution; (3) thickening ·Medicine: Gum arabic is mainly used as a suspending and emulsifying agent in oral and topical pharmaceutical preparations ·Printing industry: for wiping printing layouts ·Adhesives: used for bonding paper, wood, ceramics, glass, etc. Group: Plant Hydrocolloids. CAS No. 9000-1-5. Purity: 1.35 g/mL. Density: Water soluble. Aqueous solution is acidic to litmus. | |
gum arabic, hand-selected delicate, light yellow Quick inquiry Where to buy Suppliers range | Gum arabic (GA) is a mixture of polysaccharides and glycoproteins (GP) with properties of glue and adhesive. Gum arabic readily dissolves in water, forming a clear solution ranging in color from very pale yellow to orange-brown at a pH of about 4.5. GA is used as an emulsifier and thickener in icings, fillings, chewing gum and other confections. GA was more effective in inhibiting non-enzymatic browning and as a color preservative in dehydrated tomatoes. The addition of GA significantly improved the color stability of anthocyanins; the efficacy decreased with increasing concentrations due to changes in the conformation of the gum molecules that hindered their contact with anthocyanins. Gum arabic was found to be an excellent color preservative and inhibitor of non-enzymatic browning of dehydrated tomatoes during storage. Uses: ·Food industry: (1) role of protective colloid or stabilizer; (2) adhesiveness of aqueous solution; (3) thickening ·Medicine: Gum arabic is mainly used as a suspending and emulsifying agent in oral and topical pharmaceutical preparations ·Printing industry: for wiping printing layouts ·Adhesives: used for bonding paper, wood, ceramics, glass, etc. Group: Plant Hydrocolloids. CAS No. 9000-1-5. Purity: 1.35 g/mL. Density: Water soluble. Aqueous solution is acidic to litmus. | |
Gum Arabic, Industrial grade Quick inquiry Where to buy Suppliers range | Gum arabic (GA) is a mixture of polysaccharides and glycoproteins (GP) with properties of glue and adhesive. Gum arabic readily dissolves in water, forming a clear solution ranging in color from very pale yellow to orange-brown at a pH of about 4.5. GA is used as an emulsifier and thickener in icings, fillings, chewing gum and other confections. GA was more effective in inhibiting non-enzymatic browning and as a color preservative in dehydrated tomatoes. The addition of GA significantly improved the color stability of anthocyanins; the efficacy decreased with increasing concentrations due to changes in the conformation of the gum molecules that hindered their contact with anthocyanins. Gum arabic was found to be an excellent color preservative and inhibitor of non-enzymatic browning of dehydrated tomatoes during storage. Uses: ·Food industry: (1) role of protective colloid or stabilizer; (2) adhesiveness of aqueous solution; (3) thickening ·Medicine: Gum arabic is mainly used as a suspending and emulsifying agent in oral and topical pharmaceutical preparations ·Printing industry: for wiping printing layouts ·Adhesives: used for bonding paper, wood, ceramics, glass, etc. Group: Plant Hydrocolloids. CAS No. 9000-1-5. Purity: 1.35 g/mL. Density: Water soluble. Aqueous solution is acidic to litmus. | |
Gum Arabic, Pharmaceutical grade Quick inquiry Where to buy Suppliers range | Gum arabic (GA) is a mixture of polysaccharides and glycoproteins (GP) with properties of glue and adhesive. Gum arabic readily dissolves in water, forming a clear solution ranging in color from very pale yellow to orange-brown at a pH of about 4.5. GA is used as an emulsifier and thickener in icings, fillings, chewing gum and other confections. GA was more effective in inhibiting non-enzymatic browning and as a color preservative in dehydrated tomatoes. The addition of GA significantly improved the color stability of anthocyanins; the efficacy decreased with increasing concentrations due to changes in the conformation of the gum molecules that hindered their contact with anthocyanins. Gum arabic was found to be an excellent color preservative and inhibitor of non-enzymatic browning of dehydrated tomatoes during storage. Uses: ·Use as an emulsifier to determine lipase activity in shrimp ·For visualization of mossy fiber sprouting ·As an immunogen and coats microtiter wells in Plate ·Capture Antigen ELISA (PTA-ELISA) ·Silver enhancement for immunohistochemistry ·As part of Timm's staining solution ·In nitrocellulose-based soil adhesion assays ·Separation of Few Graphene (FLG) from Bulk Graphite Layers. Group: Plant Hydrocolloids. CAS No. 9000-1-5. Purity: 1.35 g/mL. Density: Water soluble. Aqueous solution is acidic to litmus. | |
Gum arabic, Powder, derived from the trunk exudate of the genus Acacia Quick inquiry Where to buy Suppliers range | Gum arabic (GA) is a mixture of polysaccharides and glycoproteins (GP) with properties of glue and adhesive. Gum arabic readily dissolves in water, forming a clear solution ranging in color from very pale yellow to orange-brown at a pH of about 4.5. GA is used as an emulsifier and thickener in icings, fillings, chewing gum and other confections. GA was more effective in inhibiting non-enzymatic browning and as a color preservative in dehydrated tomatoes. The addition of GA significantly improved the color stability of anthocyanins; the efficacy decreased with increasing concentrations due to changes in the conformation of the gum molecules that hindered their contact with anthocyanins. Gum arabic was found to be an excellent color preservative and inhibitor of non-enzymatic browning of dehydrated tomatoes during storage. Uses: ·Food industry: (1) role of protective colloid or stabilizer; (2) adhesiveness of aqueous solution; (3) thickening ·Medicine: Gum arabic is mainly used as a suspending and emulsifying agent in oral and topical pharmaceutical preparations ·Printing industry: for wiping printing layouts ·Adhesives: used for bonding paper, wood, ceramics, glass, etc. Group: Plant Hydrocolloids. CAS No. 9000-1-5. Purity: 1.35 g/mL. Density: Water soluble. Aqueous solution is acidic to litmus. | |
Hemorphin-7 Quick inquiry Where to buy Suppliers range | Hemorphin-7, a hemorphin peptide with antinociceptive and antihypertensive effects, is an endogenous opioid peptide derived from the β-chain of hemoglobin. Hemorphin peptides activates opioid receptors and inhibiting angiotensin-converting enzyme (ACE). The much lower affinity of hemorphin- 7 for μ-receptors as compared to other opioid peptides may be compensated by its much higher plasma concentration, resulting in biological effects of comparable magnitude. Synonyms: H-Tyr-Pro-Trp-Thr-Gln-Arg-Phe-OH; L-tyrosyl-L-prolyl-L-tryptophyl-L-threonyl-L-glutaminyl-L-arginyl-L-phenylalanine; L-Phenylalanine, N-(N2-(N2-(N-(N-(1-L-tyrosyl-L-prolyl)-L-tryptophyl)-L-threonyl)-L-glutaminyl)-L-arginyl)-. Grades: ≥97%. CAS No. 152685-85-3. Molecular formula: C49H64N12O11. Mole weight: 997.11. | |
ITI214 Quick inquiry Where to buy Suppliers range | ITI214 is a highly selective PDE1 inhibitor (Ki = 58 pM) at picomolar concentration without disrupting other PDE family members and a panel of enzymes, receptors, transporters, and ion channels. Synonyms: Lenrispodun phosphate; PDE1-IN-1 (phosphate); ITI 214; ITI-214. CAS No. 1642303-38-5. Molecular formula: C29H29FN7O5P. Mole weight: 605.56. | |
JNK-IN-7 Quick inquiry Where to buy Suppliers range | Covalent modification of IRAK1 by JNK-IN-7 is a possibility and subsequent biochemical kinase assay revealed anIC50 of ~10 nM against IRAK1. JNK-IN-7 exhibited binding inhibition of 95% or more to approximately 14 kinases at the concentration of 1.0 μM. JNK-IN-7 was next tested for its ability to inhibit the enzymatic activity of a panel of 121 kinases at a concentration of 1.0 μM. Synonyms: JNK-IN-7; JNK inhibitor;JNKIN7; JNK IN 7; JNK-IN-7. Grades: >98%. CAS No. 1408064-71-0. Molecular formula: C28H27N7O2. Mole weight: 493.56. | |
Lactate Dehydrogenase Isoenzyme 1 (LD1) (catalytic activity concentration) Quick inquiry Where to buy Suppliers range | Lactate Dehydrogenase Isoenzyme 1 (LD1) (catalytic activity concentration). Uses: For analytical and research use. Group: Enzyme Activators, Inhibitors & Substrates. Catalog: APS009294. Shipping: Dry ice. | |
LBX192 Quick inquiry Where to buy Suppliers range | LBX192 is a Liver Targeted Glucokinase Activator. It can activate the GK enzyme in vitro at low nM concentrations and reduce glucose levels during an oral glucose tolerance test in normal as well as diabetic mice. Synonyms: LBX192; LBX 192; LBX-192; NVP-LBX192; NVP-LBX-192; NVP-LBX 192; (R)-3-cyclopentyl-N-(5-methoxythiazolo[5,4-b]pyridin-2-yl)-2-(4-((4-methylpiperazin-1-yl)sulfonyl)phenyl)propanamide. Grades: 98%. CAS No. 866772-52-3. Molecular formula: C26H33N5O4S2. Mole weight: 543.70. | |
L+Lactic Acid, Calcium Salt, Pentahydrate Quick inquiry Where to buy Suppliers range | Lactic acid (2-hydroxypropanoic acid), also known as milk acid, is a chemical compound that plays a role in several biochemical processes. It was first isolated in 1780 by a Swedish chemist, Carl Wilhelm Scheele, and is a carboxylic acid with a chemical formula of C3H6O3. It has a hydroxyl group adjacent to the carboxyl group, making it an alpha hydroxy acid (AHA). In solution, it can lose a proton from the acidic group, producing the lactate ion CH3CH(OH)COO?. It is miscible with water or ethanol, and is hygroscopic. Lactic acid is chiral and has two optical isomers. One is known as L-(+)-lactic acid or (S)-lactic acid and the other, its mirror image, is D-(-)-lactic acid or (R)-lactic acid. L-(+)-Lactic acid is the biologically important isomer.In animals, L-lactate is constantly produced from pyruvate via the enzyme lactate dehydrogenase (LDH) in a process of fermentation during normal metabolism and exercise. It does not increase in concentration until the rate of lactate production exceeds the rate of lactate removal which is governed by a number of factors including: monocarboxylate transporters, concentration and isoform of LDH and oxidative capacity of tissues. The concentration of blood lactate is usually 1-2 mmol/L at rest, but can rise to over 20 mmol/L during intense exertion. Industrially, lactic acid fermentation is performed by Lactobacillus bacteria, among others. These bacteria can operate in the mouth; the acid they produce is responsible for the tooth decay known as caries.In medicine, lactate is one of the main components of Ringer's lactate or lactated Ringer's solution (Compound Sodium Lactate or Hartmann's Solution in the UK). This intravenous fluid consists of sodium and potassium cations, with lactate and chloride anions, in solution with distilled water in concentration so as to be isotonic compared to human blood. It is most commonly used for fluid resuscitation after blood loss due to trauma, surgery, or a burn injury. Group: Biochemicals. Alternative Names: Lactic Acid Calcium Salt (2:1) Pentahydrate; Propanoic Acid 2-Hydroxycalcium Salt Pentahydrate; Calcium Lactate Pentahydrate; Puracal DC. Grades: USP. CAS No. 5743-47-5. Pack Sizes: 100g, 250g, 500g, 1Kg, 2.5Kg. Molecular Formula: C6H10O6 Ca 5H2O, Molecular Weight: 308.29. US Biological Life Sciences. | Worldwide |
LY2608204 Quick inquiry Where to buy Suppliers range | LY2608204 activates glucokinase (GK) with EC50 of 42 nM at 10 mM glucose with a concentration dependent manner at lower glucose concentrations. Uses: Enzyme activators. Synonyms: LY-2608204; LY 2608204; LY2608204. Grades: >98%. CAS No. 1234703-40-2. Molecular formula: C28H37N3O3S3. Mole weight: 559.81. | |
Lycopene Quick inquiry Where to buy Suppliers range | Lycopene, in the concentration used, is not toxic and also its health benefits in adipose tissue may play a role against obesity-related complications. Lycopene in tomato puree has decreased indicating an indirect effect on lycopene stability caused by high concentration of hydrogen peroxide and the activation of peroxidase enzymes leading to the reduction of ascorbic acid and its regenerative action towards lycopene. Besides, Lycopene protected β-carotene against isomerization during reactions with singlet oxygen and radicals. These findings can explain the pattern of carotenoid isomers analyzed in fruits and vegetables, where lycopene containing samples showed higher (all-E)/(9Z)-β-carotene ratios, and also in in vivo samples such as human blood plasma. Lycopene can be used as pigment in food processing, and is also used as raw material of antioxidant health food. Uses: Ingredient of health care products. Synonyms: ψ,ψ-Carotene; all-trans-Lycopene; Lyco Vit; Lycopene 7; Lycored; NSC 407322; Redivivo; trans-Lycopene; (all-E)-2,6,10,14,19,23,27,31-Octamethyl-2,6,8,10,12,14,16,18,20,22,24,26,30-dotriacontatridecaene. Grades: 96%. CAS No. 502-65-8. Molecular formula: C40H56. Mole weight: 536.87. | |
Mavatrep Quick inquiry Where to buy Suppliers range | Mavatrep is an orally bioavailable, potent and selective TRPV1 antagonist with Ki value of 6.5 nM, which exhibits minimal effect on the enzymatic activity of CYP isoforms 3A4, 1A2, and 2D6. It antagonizes capsaicin-induced Ca2+ influx, with an IC50 value of 4.6 nM in a TRPV1 functional assay, using cells expressing recombinant human TRPV1 channels. It blocks the activation of hTRPV1 channels by Capsaicin and pH in a concentration-dependent fashion, with IC50 values of 23 and 6.8 nM respectively. It exhibits superior pharmacodynamic properties in the CFA model of inflammatory pain in vivo. It was selected for clinical development for the treatment of pain. It was developed by Johnson & Johnson and now in clinic phase 1 with no progress. Uses: Mavatrep was selected for clinical development for the treatment of pain. Synonyms: JNJ-39439335; JNJ 39439335; JNJ39439335; 2-[2-[2-[(E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-3H-benzimidazol-5-yl]phenyl]propan-2-ol. Grades: >98 %. CAS No. 956274-94-5. Molecular formula: C25H21F3N2O. Mole weight: 422.44. | |
Meropenem Trihydrate Quick inquiry Where to buy Suppliers range | A broad spectrum antibiotic that has a high affinity for cell wall-synthesizing enzymes. It is a beta-lactam and belongs to the subgroup of carbapenem. The spectrum of action includes many gram-positive and gram-negative bacteria (including Pseudomonas) and anaerobic bacteria. Konagaya et al. note the successful elimination of Agrobacterium from Cryptomeria japonica (Japanese cedar) cultures using a concentration of 10mg/L of Meropenem without observing phytotoxic effects. Group: Biochemicals. Alternative Names: [4R-[3(3S*,5S*),4α,5 β,6 β (R*) ]]-3-[[5-[ (Dimethylamino) carbonyl]-3-pyrrolidinyl]thio]-6- (1-hydroxyethyl) -4-methyl-7-oxo-1-azabicyclo[3. 2. 0]hept-2-ene-2-carboxylic Acid Trihydrate; (4R, 5S, 6S) -3-[[ (3S, 5S) -5-[ (Dimethylamino) carbonyl]-3-pyrrolidinyl]thio]-6-[ (1R) -1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3. 2. 0]hept-2-ene-2-carboxylic Acid Trihydrate; (4R, 5S, 6S) -3-[[ (3S, 5S) -5-[ (dimethylamino) carbonyl]-3-pyrrolidinyl]thio]-6-[ (1R) -1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3. 2. 0]hept-2-ene-2-carboxylic Acid Trihydrate. Grades: Highly Purified. CAS No. 119478-56-7. Pack Sizes: 500mg, 1g, 5g. Molecular Formula: C??H??N?O?S, Molecular Weight: 437.51. US Biological Life Sciences. | Worldwide |
Microcystin-LR Quick inquiry Where to buy Suppliers range | Microcystin-LR is a selective inhibitor of protein phosphatase 2A (PP2A) (IC50= 0.04 nM) and will completely inhibit this enzyme without affecting PP1 when used at a concentration of 0.5 nM.2 The PP1 IC50 is about 1.7 nM. Microcystins are at least 10 times more potent as serine/threonine PP inhibitors than okadaic acid, another microalgal toxin also used for this purpose. Uses: Enzyme inhibitors. Synonyms: Microcystin LR; Microcystin; Microcystin-a; MicrocystinLR; Cyanoginosin-LR; Toxin T 17; cyclo[2,3-didehydro-N-methylalanyl-D-alanyl-L-leucyl-(3S)-3-methyl-D-β-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-γ-glutamyl]; 5-L-Arginine-microcystin LA; cyclo(Ala-Leu-MAsp-Arg-Adda-isoGlu-Mdha). Grades: >95%. CAS No. 101043-37-2. Molecular formula: C49H74N10O12. Mole weight: 995.17. | |
Naftifine Quick inquiry Where to buy Suppliers range | Naftifine is a topical, synthetic, broad spectrum allylamine derivate. It has antifungal, antibacterial and anti-inflammatory activity and is used for the treatment of tinea pedis, tinea cruris, and tinea corporis. It can be fungicidal or fungistatic depending on the concentration and the organisms involved. It appears to interfere with sterol biosynthesis by inhibiting the enzyme squalene 2,3-epoxidase. It was developed by Merz pharma and has been listed. Uses: Naftifine has antifungal, antibacterial and anti-inflammatory activity and is used for the treatment of tinea pedis, tinea cruris, and tinea corporis. Synonyms: Naftifinum; AW105843; AW-105843; SN105843; SN-105843; N-trans-cinnamyl-n-methyl-(1-naphthylmethyl)amine. Grades: 98%. CAS No. 65472-88-0. Molecular formula: C21H21N. Mole weight: 287.41. | |
N-Methyldeoxynojirimycin Quick inquiry Where to buy Suppliers range | N-Methyldeoxynojirimycin is a remarkably efficacious inhibitor applied extensively in the research of hereditary disorders, including Gaucher's disease and Tay-Sachs disease. This phenomenal compound operates by suppressing the enzymatic activity of glucosidase, thereby inducing a noteworthy decline in the concentrations of glucosylceramide and glycolipids. Synonyms: 1,5-Dideoxy-1,5-imino-1-methyl-D-sorbitol; N-Me-DNJ. CAS No. 69567-10-8. Molecular formula: C7H15NO4. Mole weight: 177.2. | |
Oclacitinib Quick inquiry Where to buy Suppliers range | Oclacitinib, also known as PF03394197, is a novel Janus kinase inhibitor with activity against cytokines involved in allergy. Oclacitinib inhibited JAK family members by 50% at concentrations (IC50 's) ranging from 10 to 99 nM and did not inhibit a panel of 38 non-JAK kinases (IC50 's > 1000 nm). Oclacitinib was most potent at inhibiting JAK1 (IC50 = 10 nm). Oclacitinib also inhibited the function of JAK1-dependent cytokines involved in allergy and inflammation (IL-2, IL-4, IL-6, and IL-13) as well as pruritus (IL-31) at IC50 's ranging from 36 to 249 nm. Oclacitinib had minimal effects on cytokines that did not activate the JAK1 enzyme in cells (erythropoietin, granulocyte/macrophage colony-stimulating factor, IL-12, IL-23; IC50 's > 1000 nm). These results demonstrate that oclacitinib is a targeted therapy that selectively inhibits JAK1-dependent cytokines involved in allergy, inflammation, and pruritus and suggests these are the mechanisms by which oclacitinib effectively controls clinical signs associated with allergic skin disease in dogs. Synonyms: Cyclohexanemethanesulfonamide, N-methyl-4-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-, trans-; trans-N-Methyl-4- (methyl-7H-pyrrolo[2, 3-d]pyrimidin-4-ylamino) cyclohexanemethanesulfonamide; JAKi; PF 03394197. Grades: 98%. CAS No. 1208319-26-9. Molecular formula: C15H23N5O2S. Mole weight: 337.44. | |
Ovalbumin (154-159) Quick inquiry Where to buy Suppliers range | Ovalbumin (154-159) shows higher inhibition of the angiotensin-converting enzyme (ACE) at a concentration of 70 μM for 50% inhibition of ACE. Synonyms: OVA (154-159); H-Thr-Asn-Gly-Ile-Ile-Arg-OH; Egg white albumen (154-159); L-threonyl-L-asparagyl-glycyl-L-isoleucyl-L-isoleucyl-L-arginine; H-TNGIIR-OH. Grades: ≥95%. CAS No. 1370698-94-4. Molecular formula: C28H52N10O9. Mole weight: 672.78. | |
P1,P5-Di(adenosine-5')pentaphosphate trilithium salt Quick inquiry Where to buy Suppliers range | A diadenosine polyphosphate stored in secretory granules of thrombocytes, chromaffin and neuronal cells. After release into the extracellular space, it affects a variety of biological activities in a wide range of target tissues. In the nervous system it acts through various purinergic receptors. It also activates 5?-nucleotidase and inhibits adenosine kinase activity in vitro. Ap5A is metabolized by soluble enzymes in the blood plasma and by membrane-bound ectoenzymes of a number of cell types including endothelial and smooth muscle cells. In cardiac muscle, pM to nM concentrations significantly increase the open-probability of ryanodine-receptor (RyR2) gates, with prolonged action due to slow dissociation from the receptor. Group: Biochemicals. Alternative Names: P1,P5-Di(adenosine-5) pentaphosphate pentalithium salt, 94108-02-8, A(5)P5(5)A, AC1O4WDE, D6392_SIGMA, CTK8G2238, EINECS 302-339-2, AP5A lithium salt P1,P5-Di(adenosine-5) pentaphosphate pentalithium salt, AG-H-86941, Diadenosine pentaphosphate trilithium salt, Diadenosine pentaphosphate pentalithium salt, K00187, A(5 inverted exclamation marka)P5(5 inverted exclamation marka)A trilithium salt, Adenosine 5-(hexahydrogen pentaphosphate), 5.5-ester with adenosine, pentalithium salt, P1,P5-Di(adenosine-5 inverted exclamation marka) pentaphosphate trilithium salt, 75522-97-3, pentalithium bis[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-oxidophosphoryl] phosphate. Grades: Highly Purified. CAS No. 75522-97-3. Pack Sizes: 25mg, 50mg, 100mg, 250mg. Molecular Formula: C20H26N10O22P5Li3, Molecular Weight: 934.17. US Biological Life Sciences. | Worldwide |
PD 198306 Quick inquiry Where to buy Suppliers range | PD 198306, an amino-benzamide compound, is an orally bioavailable and potent inhibitor of MAPK kinase 1/2 (MEK1/2; IC50 = 8 nM). It inhibits isolated enzyme at a concentration of 8 nM and inhibits MEK activity in synovial fibroblasts at concentrations of 30-100 nM. It is selective for MEK1/2 over ERK, c-Src, PI3Kγ, and cyclin-dependent kinases (IC50s = >1 μM). Synonyms: PD-198306; PD 198306; PD198306; N-(Cyclopropylmethoxy)-3,4,5-trifluoro-2-[(4-iodo-2-methylphenyl)amino]-benzamide. Grades: ≥98% by HPLC. CAS No. 212631-61-3. Molecular formula: C18H16F3IN2O2. Mole weight: 476.23. | |
Prostaglandin EP2 Receptor Antagonist, TG6-10-1 ( (E) -N- (2- (2- (trifluoromethyl) -1H-indol-1-yl) ethyl) -3- (3, 4, 5-trimethoxyphenyl) acrylamide, EP2 Antagonist, TG6-10-1) Quick inquiry Where to buy Suppliers range | A cell-permeable, 3-acryl-acrylamide derivative that acts as a highly potent, selective, and competitive antagonist of prostaglandin E2 receptor (EP2, Kb = 17.8nM). Exhibits about 300-fold selectivity for the EP2 receptor over human EP3, EP4, and IP receptors, about 100- fold selectivity over human EP1, 25-fold selectivity against human FP and TP, and 10-fold selectivity against human DP1 receptors. Does not affect the activity of about 40 enzymes, ion channels, receptors, and neurotransmitters even at higher concentrations (10uM). Shown to significantly reduce the induction of several inflammatory cytokines and chemokines and reduces the opening of blood-brain barrier during neuronal inflammation. Displays good pharmacokinetic properties with a half-life of 1.6 h and brain to plasma ratio of 1.6 in a murine model (5mg/kg i.p.). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??F?N?O?. US Biological Life Sciences. | Worldwide |
Qc 1 Quick inquiry Where to buy Suppliers range | Qc 1 is a reversible, non-competitive inhibitor of threonine dehydrogenase (TDH) (IC50 ~500 nM), with no detectable inhibition of other dehydroxygenase enzymes at concentrations up to 10 mM. It induces autophagy and inhibits cell proliferation in mouse embryonic stem (ES) cells. Synonyms: Qc1; Qc-1; Qc 1; 1,2,3,4-Tetrahydro-4-oxo-N-(phenylmethyl)-2-thioxo-3-[3-(trifluoromethyl)phenyl]-7-quinazolinecarboxamide; Qc1; Qc-1; Qc 1. Grades: ≥98% by HPLC. CAS No. 403718-45-6. Molecular formula: C23H16F3N3O2S. Mole weight: 455.45. | |
S-(5'-Adenosyl)-L-Methionine-d3 Disulfate Salt (Mixture of Diastereomers) Quick inquiry Where to buy Suppliers range | Labelled S-(5-Adenosyl)-L-methionine. Methyl donor; cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. It is also involved in regulating liver function, growth, and response to injury. Group: Biochemicals. Alternative Names: 5-[[(3S)-3-Amino-3-carboxypropyl](methyl-d3)sulfonio]-5-deoxyadenosine Disulfate; 5-[(L-3-Amino-3-carboxypropyl)(methyl-d3)sulfonio]-5-deoxyadenosine Disulfate; S-Adenosylmethionine-d3 Disulfate; Active Methionine-d3 Disulfate; Ademetionine-d3 Disulfate; L-S-Adenosylmethionin-d3 Disulfate; S-Adenosyl-L-methionine-d3 Disulfate. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C??H??D?N?O??S?, Molecular Weight: 597.61. US Biological Life Sciences. | Worldwide |
S-(5'-Adenosyl)-L-Methionine Disulfate Quick inquiry Where to buy Suppliers range | Methyl donor; cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. It is also involved in regulating liver function, growth, and response to injury. Group: Biochemicals. Alternative Names: 5'- [ [ (3S) -3-Amino-3-carboxypropyl] methylsulfonio] -5'-deoxyadenosine Disulfate; 5'-[ (L-3-Amino-3-carboxypropyl) methylsulfonio]-5'-deoxyadenosine Disulfate; S-Adenosylmethionine Disulfate; Active Methionine Disulfate; Ademetionine Disulfate; L-S-Adenosylmethionin Disulfate; S-Adenosyl-L-methionine Disulfate. Grades: Highly Purified. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C15H26N6O13S, Molecular Weight: 594.59. US Biological Life Sciences. | Worldwide |