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Heterocyclic Organic Compound. Alternative Names: conotoxin GS. CAS No. 115757-31-8. Catalog: ACM115757318.
α-Conotoxin AuIB
α-Conotoxin AuIB is a selective antagonist of α3β4 nicotinic acetylcholine receptors. It shows > 100-fold selectivity over other receptor subunit combinations. Synonyms: alfa-Conotoxin AuIB; Gccsyppcfa tnpdc. CAS No. 216299-21-7. Molecular formula: C65H89N17O21S4. Mole weight: 1572.76.
α-Conotoxin EI
α-Conotoxin EI is a selective antagonist of neuromuscular nicotinic receptors α1β1γ&delta. It shows selectivity for α/δ sites over α/γ sites in Torpedo. Synonyms: RDXCCYHPTC NMSNPQIC; 170663-33-9; alpha-Conotoxin EI; ALPHA-CONOTOXIN EL; ?-Conotoxin EI; PD079395. Grades: >96%. CAS No. 170663-33-9. Molecular formula: C83H125N27O27S5. Mole weight: 2093.4.
α-Conotoxin EI (free acid)
α-Conotoxin EI (free acid) is a nicotinic acetylcholine receptor ligand. Synonyms: α-Conotoxin El, Conus ermineus, free acid; H-Arg-Asp-Hyp-Cys-Cys-Tyr-His-Pro-Thr-Cys-Asn-Met-Ser-Asn-Pro-Gln-Ile-Cys-OH (Disulfide bridge: Cys4-Cys10, Cys5-Cys18). Grades: ≥95%. CAS No. 1926163-14-5. Molecular formula: C83H124N26O28S5. Mole weight: 2094.37.
α-Conotoxin GI
α-conotoxin GI (alpha-conotoxin GI) is a conopeptide that has been isolated from the venom of the cone snail Conus geographus. α-conotoxin GI is a competitive antagonist of the muscle-type nicotinic acetylcholine receptors (nAChR) such as α-conotoxin MI or d-Turbocurarine. Synonyms: Conotoxin GI; Conotoxin G I; alpha-Conotoxin G I; Myotoxin from Conus geographus venom; alpha-Conotoxin G I (reduced), cyclic (2-7),(3-13)-bis(disulfide). Grades: > 95 %. CAS No. 76862-65-2. Molecular formula: C55H80N20O18S4. Mole weight: 1437.61.
α-Conotoxin ImI
α-Conotoxin ImI is a nicotinic acetylcholine receptor ligand isolated from the snail Conus imperialis. It shows selectivity for homomeric α7 and α9 receptors with IC50 values of 220 and 1800 nM respectively, but shows no effect on α2β2, α2β4, α3β2, α3β3, α4β2 and α4β4 subunit combinations. It mainly acts as an antagonist in central nervous system. It was sold under license for Cognetix for research purposes only. Synonyms: alpha-Ctx-imi. CAS No. 156467-85-5. Molecular formula: C52H78N20O15S4. Mole weight: 1351.60.
α-Conotoxin MI
α-Conotoxin MI has been isolated from the venom of the sea snail Conus imperialis. The conotoxin is a ligand for nicotinic acetylcholine receptors. Synonyms: Alpha-Conotoxin MI; Conotoxin G I, 1-(N2-glycyl-L-arginine)-4-L-histidine-9-L-lysine-10-L-asparagine-. CAS No. 88217-10-1. Molecular formula: C58H88N22O17S4. Mole weight: 1493.72.
α-Conotoxin MII
α-Conotoxin MII is a nicotinic acetylcholine receptor antagonist. It is highly potent, selective and competitive for α3β2 subunit. Its IC50 value is 0.5-3.5 nM at α3β2 expressed in Xenopus oocytes. It also potently prevents β3-containing neuronal nicotinic receptors. Synonyms: Alpha-Conotoxin MII; H-Gly-Cys(1)-Cys(2)-Ser-Asn-Pro-Val-Cys(1)-His-Leu-Glu-His-Ser-Asn-Leu-Cys(2)-NH2; glycyl-L-cysteinyl-L-cysteinyl-L-seryl-L-asparagyl-L-prolyl-L-valyl-L-cysteinyl-L-histidyl-L-leucyl-L-alpha-glutamyl-L-histidyl-L-seryl-L-asparagyl-L-leucyl-L-cysteinamide (2->8),(3->16)-bis(disulfide). Grades: ≥95%. CAS No. 175735-93-0. Molecular formula: C67H103N23O22S4. Mole weight: 1710.99.
α-Conotoxin PIA
α-Conotoxin PIA is a nicotinic acetylcholine receptor antagonist. It is selective for α6-containing nicotinic receptors. It can discriminate between the closely related α6 and α3 subunits. It was sold under license for Cognetix for research purposes only. CAS No. 669050-68-4. Molecular formula: C79H125N27O25S4. Mole weight: 1981.30.
α-Conotoxin PnIA
α-Conotoxin PnIA is a nicotinic acetylcholine receptor antagonist. It is selective for α3β2 nAChR receptors with IC50 value of 9.56 nM. It was sold under license for Cognetix for research purposes only. Synonyms: alpha-conotoxin PnIA; 705300-84-1; A-CONOTOXIN PNIACHEMBL4443205GTPL3982. Grades: >97%. CAS No. 705300-84-1. Molecular formula: C65H95N19O22S4. Mole weight: 1622.82.
Alpha-conotoxin si
Heterocyclic Organic Compound. Alternative Names: ALPHA-CONOTOXIN SI;ALPHA-CGTX SI;H-ILE-CYS-CYS-ASN-PRO-ALA-CYS-GLY-PRO-LYS-TYR-SER-CYS-NH2;ILE-CYS-CYS-ASN-PRO-ALA-CYS-GLY-PRO-LYS-TYR-SER-CYS-NH2;L-Cysteinamide, L-isoleucyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinylglycyl-L-pro. CAS No. 115797-06-3. Molecular formula: C55H84N16O16S4. Mole weight: 1353.61. Catalog: ACM115797063.
Biotinyl-εAhx-ω-Conotoxin GVIA
Biotinyl-εAhx-ω-Conotoxin GVIA, a biotinylated ω-conotoxin GVIA, is a useful calcium channel characterization ligand. Synonyms: Biotinyl-εAhx-Cys-Lys-Ser-Hyp-Gly-Ser-Ser-Cys-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys-Cys-Arg-Ser-Cys-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys-Tyr-NH2 (Disulfide bridge: Cys2-Cys17, Cys9-Cys20, Cys16-Cys27); ω-Conotoxin GVIA, 2-[N6-[6-[[5-(hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl)-1-oxopentyl]amino]-1-oxohexyl]-L-lysine]-, [3aS-(3aα,4β,6aα)]-. Grades: ≥95%. CAS No. 151928-23-3. Molecular formula: C136H207N41O46S7. Mole weight: 3376.85.
Synonyms: Conotoxin G IIIB; Geographutoxin II; H-Arg-Asp-Cys-Cys-Thr-Hyp-Hyp-Arg-Lys-Cys-Lys-Asp-Arg-Arg-Cys-Lys-Hyp-Met-Lys-Cys-Cys-Ala-NH2. CAS No. 140678-12-2. Molecular formula: C101H175N39O30S7. Mole weight: 2640.17.
ω-Conotoxin GVIA
ω-Conotoxin GVIA is a peptide neurotoxin first isolated from the marine snail Conus geographus L. It selectively and reversibly blocks specific voltage-dependent N-type Ca2+ channels in neurons, but not in muscle. It reduces (RS)-3,5-DHPG2-induced long term depression in vivo. It does not bind to either the dihydropyridine or verapamil binding sites. It is used as a powerful probe for exploring the vertebrate pre-synaptic terminal. Synonyms: omega-Conotoxin gvia. CAS No. 106375-28-4. Molecular formula: C120H182N38O43S6. Mole weight: 3037.34.
ω conotoxin MVIIA (omega conotoxin MVIIA) has been isolated from the venom of the cone Conus magus. Omega-conotoxins act at presynaptic membranes, they bind and block voltage-sensitive calcium channels (VSCC). Synonyms: Ziconotide; Prialt. Grades: 98%. CAS No. 107452-89-1. Molecular formula: C102H172N36O32S7. Mole weight: 2639.2.
ω-conotoxin MVIIC (omega conotoxin MVIIC) is a conotoxin that has been isolated from the venom of the cone Conus magus. ω-conotoxin MVIIC is a blocker of P/Q and N-type calcium channels. Synonyms: ω-Conotoxin MVIIC; L-cysteinyl-L-lysyl-glycyl-L-lysyl-glycyl-L-alanyl-L-prolyl-L-cysteinyl-L-arginyl-L-lysyl-L-threonyl-L-methionyl-L-tyrosyl-L-alpha-aspartyl-L-cysteinyl-L-cysteinyl-L-seryl-glycyl-L-seryl-L-cysteinyl-glycyl-L-arginyl-L-arginyl-glycyl-L-lysyl-L-cysteinamide (1->16),(8->20),(15->26)-tris(disulfide); H-Cys-Lys-Gly-Lys-Gly-Ala-Pro-Cys-Arg-Lys-Thr-Met-Tyr-Asp-Cys-Cys-Ser-Gly-Ser-Cys-Gly-Arg-Arg-Gly-Lys-Cys-NH2 (Disulfide bridge: Cys1-Cys16, Cys8-Cys20, Cys15-Cys26); SNX-230. Grades: ≥97% by HPLC. CAS No. 147794-23-8. Molecular formula: C106H178N40O32S7. Mole weight: 2749.25.
Tide FluorTM 5WS-ω-Conotoxin GVIA
Tide FluorTM 5WS-ω-Conotoxin GVIA is fluorescent dye-labeled ω-Conotoxin GVIA from the venom of the fish-hunting cone snail C. geographus, excitation at 649 nm, emission at 664 nm. Tide FluorTM 5WS has strong fluorescence and excellent photostability. The cone snail venom effectively blocks calcium channels in neurons. This presynaptic inhibition of calcium influx prevents voltage-activated acetylcholine release. Synonyms: Tide FluorTM 5WS-Cys-Lys-Ser-Hyp-Gly-Ser-Ser-Cys-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys-Cys-Arg-Ser-Cys-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys-Tyr-NH2 (Disulfide bridge: Cys1-Cys16, Cys8-Cys19, Cys15-Cys26). Molecular formula: C120H182N38O43S6 + dye. Mole weight: 3769.
ACV 1
ACV 1 has been found to be a neuronal nicotinic receptor antagonist and could probably alleviate neuropathic pain. Synonyms: Conotoxin Vc1.1. Grades: ≥98% by HPLC. CAS No. 740980-24-9. Molecular formula: C71H103N23O25S4. Mole weight: 1806.98.
Boc-(2S,4S)-4-amino-1-Fmoc-pyrrolidine-2-carboxylic Acid is used to prepare low molecular weight cyclic peptides as inhibitors of SDF-1 binding to CXCR4. It is also used to design α-conotoxin analogs targeting α7 nicotinic acetylcholine receptors. Synonyms: Boc-(2S,4S)-4-amino-1-Fmoc-pyrrolidine-2-carboxylic acid; (2S,4S)-Boc-4-amino-1-fmoc-pyrrolidine-2-carboxylic acid; 1,2-Pyrrolidinedicarboxylic acid,4-[[(1,1-dimethylethoxy)carbonyl]amino]-, 1-(9H-fluoren-9-ylmethyl)ester, (2S,4S)-; (4S)-1-Fmoc-4-(Boc-amino)-L-proline; (2S,4S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)-4-((tert-butoxycarbonyl)amino)pyrrolidine-2-carboxylic acid. Grades: ≥ 98% (HPLC). CAS No. 221352-74-5. Molecular formula: C25H28N2O6. Mole weight: 452.60.
Ziconotide acetate
Ziconotide acetate. Group: Biochemicals. Alternative Names: ω-Conotoxin M VIIA acetate; ω-Conopeptide MVIIA acetate; Prialt acetate. Grades: Highly Purified. CAS No. 914454-03-8. Pack Sizes: 1mg, 2mg. Molecular Formula: C104H176N36O34S7. US Biological Life Sciences.
Worldwide
Ziconotide Polyacetate
Α selective antagonist of N-type voltage sensitive calcium channels (VSCC). Blocks neurotransmitter release by preventing depolarization-induced calcium influx. Used as a ligand for binding studies of voltage sensitive calcium channels. Analgesic; neuroprotective. Group: Biochemicals. Alternative Names: ω-Conotoxin M VIIA Acetate; ω-Conopeptide MVIIA Acetate; Prialt Acetate; SNX 111. Grades: Highly Purified. Pack Sizes: 250ug. US Biological Life Sciences.
Worldwide
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