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| Product | Description | |
|---|---|---|
| Corticotropin-releasing factor | Corticotropin-Releasing Factor (CRF) is a neuropeptide of utmost significance is assumes a pivotal role in the intricate regulation of the physiological stress response. Synonyms: ACTH-releasing factor; ACTH-releasing hormone; Corticoliberin; Corticotropin-releasing activity; Corticotropin-releasing hormone; CRF; CRF (hormone). Grade: 95%. CAS No. 9015-71-8. |  |
| Corticotropin Releasing Factor Antagonist | Corticotropin Releasing Factor Antagonist is a groundbreaking biomedical compound, meticulously aiming to modulate the intricacies of the enigmatic Corticotropin Releasing Factor (CRF) system. Synonyms: alpha-Helical CRF (9-41); Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Met-Leu-Glu-Met-Ala-Lys-Ala-Glu-Gln-Glu-Ala-Glu-Gln-Ala-Ala-Leu-Asn-Arg-Leu-Leu-Leu-Glu-Glu-Ala-NH2; α-Helical corticotropin releasing factor fragment (9-41). Grade: ≥97% by HPLC. CAS No. 99658-03-4. Molecular formula: C166H274N46O53S2. Mole weight: 3826.36. | |
| Anti-Corticotropin Releasing Factor antibody produced in rabbit | IgG fraction of antiserum, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. |  |
| 1,3-Dichloro-5-isocyanatobenzene | 1,3-Dichloro-5-isocyanatobenzene is a reagent used in the synthesis of carbamate and aryl ether substituted pyrazinones as corticotropin releasing factor-1 receptor antagonists as well as the synthesis of novel triazolor pyridine derivatives. Group: Biochemicals. Grades: Highly Purified. CAS No. 34893-92-0. Pack Sizes: 5g, 10g. Molecular Formula: C7H3Cl2NO. US Biological Life Sciences. |  Worldwide |
| 2,4-Dichloro-6-methyltriazine | 2,4-Dichloro-6-methyltriazine is a reagent used to prepare triazinyl-amines as inhibitors of HIV-1 reverse transcriptase. It is also used in the synthesis of anilinotriazine corticotropin releasing hormone antagonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 1973-4-2. Pack Sizes: 500mg, 1g. Molecular Formula: C4H3Cl2N3, Molecular Weight: 163.99. US Biological Life Sciences. | Worldwide |
| 2-Chloro-5-nitroquinoline | 2-Chloro-5-nitroquinoline is used in the synthesis of potent, orally active corticotropin-releasing factor-1 receptor antagonists. Group: Biochemicals. Alternative Names: 5-Nitro-2-chloroquinoline; NSC 261562. Grades: Highly Purified. CAS No. 13067-94-2. Pack Sizes: 500mg. US Biological Life Sciences. | Worldwide |
| 2-Hydroxy-4-methylpyridine-d3 | 2-Hydroxy-4-methylpyridine-d3 is the isotope labelled analog of 2-Hydroxy-4-methylpyridine (H949890); an intermediate used to prepare oxobenzopyrancarboxyl ate derivatives as inhibitors of serine proteases and human leukocyte elastase. It is also used in the synthesis of (indanylamino) (pyridinyloxy) pyrazines and analogs as corticotropin releasing factor type-1 receptor antagonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 1185316-03-3. Pack Sizes: 5mg, 10mg. Molecular Formula: C6H4D3NO, Molecular Weight: 112.14. US Biological Life Sciences. | Worldwide |
| 2-Hydroxy-4-methylpyridine-d6 | 2-Hydroxy-4-methylpyridine-d6 is the isotope labelled analog of 2-Hydroxy-4-methylpyridine (H949890); an intermediate used to prepare oxobenzopyrancarboxyl ate derivatives as inhibitors of serine proteases and human leukocyte elastase. It is also used in the synthesis of (indanylamino) (pyridinyloxy) pyrazines and analogs as corticotropin releasing factor type-1 receptor antagonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 916979-13-0. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C6HD6NO, Molecular Weight: 115.16. US Biological Life Sciences. | Worldwide |
| 3-[6-(Dimethylamino)-4-methyl-3-pyridinyl]-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine | 3-[6-(Dimethylamino)-4-methyl-3-pyridinyl]-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine, is a potent and Orally active Corticotropin-Releasing factor 1 receptor antagonists, which is hown to reduce negative emotional symptoms of acute and protracted alcohol withdrawal, and thus used for the treatment of alcoholism. Group: Biochemicals. Grades: Highly Purified. CAS No. 195055-03-9. Pack Sizes: 1mg. Molecular Formula: C22H32N6, Molecular Weight: 380.53. US Biological Life Sciences. | Worldwide |
| ACTH (1-10), human | Adrenocorticotropic hormone (ACTH) (1-10) is an N-terminal peptide fragment of ACTH, a peptide hormone produced by the anterior pituitary gland that is involved in the biological stress response. Synonyms: H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-OH; L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-alpha-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophyl-glycine; ACTH (1-10) (human, mouse, rat, porcine, bovine, ovine); Adrenocorticotropic Hormone (1-10); Corticotropin (1-10); Adrenocorticotropic Hormone (ACTH) (1-10), human. Grade: ≥97% by HPLC. CAS No. 2791-5-1. Molecular formula: C59H78N16O16S. Mole weight: 1299.41. | |
| ACTH 11-24 | ACTH(11-24) is a fragment of the adrenocorticotropic hormone (ACTH) and an antagonist of the adrenocorticotropic hormone (ACTH) receptor that induces cortisol release. Synonyms: Adrenocorticotropic Hormone (11-24); H-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH; L-lysyl-L-prolyl-L-valyl-glycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-valyl-L-lysyl-L-valyl-L-tyrosyl-L-proline; a11-24-Corticotropin; alpha11-24-Corticotropin; Adrenocorticotropic hormone fragment 11-24, human. Grade: ≥90%. CAS No. 4237-93-8. Molecular formula: C77H134N24O16. Mole weight: 1652.04. | |
| ACTH 1-13 | ACTH (1-13) is a 13-aa peptide with cytoprotective effects in the model of ethanol induced gastric lesions in rats. Uses: Hormones. Synonyms: Adrenocorticotropic Hormone (1-13); H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-OH; L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-alpha-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophyl-glycyl-L-lysyl-L-prolyl-L-valine; Tridecactide; Des-acetyl MSH; DE-alpha-Msh; (Des-acetyl)-alpha-MSH; alpha 1-13-Corticotropin, human; Desacetyl alpha-melanocyte-stimulating hormone; a1-13-Corticotropin. Grade: ≥95%. CAS No. 22006-64-0. Molecular formula: C75H106N20O19S. Mole weight: 1623.83. | |
| ACTH 1-14 | ACTH(1-14) is a fragment of the adrenocorticotropic hormone that regulates the production of cortisol and androgens. Synonyms: Adrenocorticotropic Hormone Fragment 1-14; Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly; alpha1-14-Corticotropin; L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-alpha-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophyl-glycyl-L-lysyl-L-prolyl-L-valyl-glycine; Acth(1-14) huamn. Grade: ≥90%. CAS No. 25696-21-3. Molecular formula: C77H109N21O20S. Mole weight: 1680.88. | |
| ACTH (1-14) acetate | ACTH (1-14) acetate is a fragment of the adrenocorticotropic hormone that regulates the production of cortisol and androgens. Synonyms: Adrenocorticotropic Hormone Fragment 1-14 acetate; H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-OH.CH3CO2H; L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-alpha-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophyl-glycyl-L-lysyl-L-prolyl-L-valyl-glycine acetic acid; α1-14-Corticotropin acetate; α-Melanotropin (Rana catesbeiana) acetate; α-MSH (chicken) acetate; ACTH 1-14 acetate; α1-14-ACTH acetate. Grade: ≥95%. Molecular formula: C79H113N21O22S. Mole weight: 1740.96. | |
| ACTH 1-17 | ACTH (1-17) is a peptide fragment of ACTH, a tropic hormone produced by the anterior pituitary. Synonyms: Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg; Alpha1-17-ACTH; a1-17-Corticotropin; L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-alpha-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophyl-glycyl-L-lysyl-L-prolyl-L-valyl-glycyl-L-lysyl-L-lysyl-L-arginine; 1-Ala-17-Lys-ACTH 4-amino-n-butylamide; 1-beta-Alanine-17-(L-2,6-diamino-N-(4-aminobutyl)hexanamide)-alpha1-17-corticotrophin; alsactide; Synchrodyn; Adrenocorticotropic Hormone Fragment 1-17 human, rat. Grade: 98%. CAS No. 7266-47-9. Molecular formula: C95H145N29O23S. Mole weight: 2093.41. | |
| ACTH (1-39) (Human) | Potent endogenous melanocortin receptor 2 (MC2) agonist (EC50 = 57 pM). Component of the hypothalamic-pituitary-adrenal (HPA) axis that stimulates glucocorticoid production and release from the adrenal cortex. Induces insulin resistance, promotes a proinflammatory profile and stimulates UCP-1 in adipocytes in vitro. Group: Biochemicals. Alternative Names: Adrenocorticotropic hormone (1-39); Adrenocorticotropin; Corticotropin. Grades: Highly Purified. CAS No. 12279-41-3. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| ACTH (1-39), Porcine | ACTH (1-39) is a potent agonist of melanocortin receptor 2 (MC2R) with an EC50 value of 57 pM in HeLa cells expressing the mouse receptor. Synonyms: Adrenocorticotropic Hormone from porcine pituitary; Adrenocorticotropic Hormone Fragment 1-39; Corticotropin A. Grade: 95%. CAS No. 9061-27-2. Molecular formula: C210H314N56O57S. Mole weight: 4567.15. | |
| ACTH (2-24) (human, bovine, rat) | ACTH (2-24) (human, bovine, rat). Synonyms: H-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH; Corticotropin (2-24); L-tyrosyl-L-seryl-L-methionyl-L-alpha-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophyl-glycyl-L-lysyl-L-prolyl-L-valyl-glycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-valyl-L-lysyl-L-valyl-L-tyrosyl-L-proline. Grade: ≥95%. CAS No. 67654-32-4. Molecular formula: C133H205N39O29S. Mole weight: 2846.36. | |
| ACTH (4-10) | ACTH (4-10) is a fragment of Adrenocorticotropic Hormone (ACTH), a melanocortin 4 (MC4R) receptor agonist. Synonyms: α-MSH (4-10); ACTH (4-10), human; corticotropin (4-10); H-Met-Glu-His-Phe-Arg-Trp-Gly-OH; Met-glu-his-phe-arg-trp-gly. Grade: >95%. CAS No. 4037-1-8. Molecular formula: C44H59N13O10S. Mole weight: 962.08. | |
| ACTH (4-10) (human, mouse, rat, porcine, bovine, ovine) trifluoroacetate salt | Adrenocorticotropic hormone (ACTH) (4-10) is an endogenous peptide fragment of ACTH, a peptide hormone produced by the anterior pituitary gland that is involved in the biological stress response. Synonyms: Adrenocorticotropic hormone (4-10); Corticotropin (4-10); H-Met-Glu-His-Phe-Arg-Trp-Gly-OH. Grade: ≥95%. Molecular formula: C44H59N13O10S·xCF3COOH. Mole weight: 962.09. | |
| ACTH (6-24) (human, mouse, rat, porcine, bovine, ovine) trifluoroacetate salt | ACTH (6-24) is a peptide fragment of adrenocorticotropic hormone, a peptide hormone found in the brain that is involved in the biological stress response. Synonyms: HFRWGKPVGKKRRPVKVYP; Corticotropin-(6-24)-peptide. Grade: ≥95%. CAS No. 33512-65-1. Molecular formula: C111H175N35O21·xCF3COOH. Mole weight: 2335.8. | |
| ACTH (7-38) (human) | ACTH (7-38) (human) is the 7-38 fragment of human ACTH (1-39). human ACTH (1-39), known as a corticotropin inhibitory peptide (CIP), is an antagonist of the ACTH receptor and has no any corticosteroid activity [1]. Uses: Scientific research. Group: Peptides. CAS No. 68563-24-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P4874. |  |
| Adrenocorticotropic Hormone (ACTH) (1-39), human | Adrenocorticotropic Hormone (ACTH) (1-39), human is a melanocortin receptor agonist. Uses: Scientific research. Group: Peptides. Alternative Names: 1-39-Corticotropin (human). CAS No. 12279-41-3. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-P1211. | |
| Adrenocorticotropic Hormone (ACTH) (18-39), human TFA | Adrenocorticotropic Hormone (ACTH) (18-39), human TFA is a corticotropinlike intermediate lobe peptide, which is is produced in the melanotrophs of the intermediate lobe of the pituitary [1]. Uses: Scientific research. Group: Peptides. Alternative Names: CLIP (human) TFA. CAS No. 73724-75-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1476A. | |
| Adrenocorticotropic Hormone Fragment 7-38 human | Adrenocorticotropic Hormone Fragment 7-38 human. Synonyms: Corticostatin; (7-28)-Corticotropin; Acth(7-38); CIP peptide. CAS No. 68563-24-6. Molecular formula: C167H257N47O46. Mole weight: 3659.11. | |
| Antalarmin | Antalarmin is a selective nonpeptide corticotropin-releasing factor receptor 1 ( CRHR1 ) antagonist with a K i of 2.7 nM. Antalarmin can pass through the blood - brain barrier [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 157284-96-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-124475. | |
| Antalarmin hydrochloride | Antalarmin (hydrochloride) is an oral active non-peptide corticotropin-releasing hormone receptor 1 (CRHR1) antagonist with a K i of 1 nM. Antalarmin hydrochloride suppresses CRH-induced ACTH secretion and blocks CRH and novelty induced anxiety-like behavior in animal models. Antalarmin hydrochloride produces anti-inflammatory effects in arthritis models, and suppresses stress-induced gastric ulceration related to irritable bowel syndrome [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 220953-69-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103377. | |
| Antalarmin hydrochloride | Antalarmin hydrochloride is the hydrochloride salt of antalarmin, which is a selective nonpeptide antagonist of the corticotropin-releasing hormone (CRH) receptor 1 with Ki value of 1 nM. It suppresses CRF-induced ACTH secretion and blocks CRF- and novelty-induced anxiety-like behavior in animal models of anxiety. It also can reduce cardiovascular, endocrinological and behavioral responses to stressful stimuli through its antagonism of central CRH signaling. It produces anti-inflammatory effects in arthritis models by reducing dose escalation in cocaine-addicted rats and suppresses stress-induced gastric ulceration related to irritable bowel syndrome. Synonyms: N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Monohydrochloride; N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Hydrochloride. Grade: ≥99% by HPLC. CAS No. 220953-69-5. Molecular formula: C24H35N4Cl. Mole weight: 415.01. | |
| Antisauvagine-30 | Antisauvagine-30 is a selective, competitive and potent corticotropin-releasing factor CRF2 receptor antagonist with Kd values of 153.6 and 1.4 nM for binding to rat CRF1 and mouse CRF2β receptors respectively. It prevents stress-enhanced fear conditioning and MEK 1/2-dependent activation of ERK1/2 in mice in vivo. It inhibits sauvagine-stimulated cAMP accumulation in HEK-mCRF2β cells. Synonyms: (D-Phe11,His12)-Sauvagine (11-40); H-D-Phe-His-Leu-Leu-Arg-Lys-Met-Ile-Glu-Ile-Glu-Lys-Gln-Glu-Lys-Glu-Lys-Gln-Gln-Ala-Ala-Asn-Asn-Arg-Leu-Leu-Leu-Asp-Thr-Ile-OH; D-phenylalanyl-L-histidyl-L-leucyl-L-leucyl-L-arginyl-L-lysyl-L-methionyl-L-isoleucyl-L-alpha-glutamyl-L-isoleucyl-L-alpha-glutamyl-L-lysyl-L-glutaminyl-L-alpha-glutamyl-L-lysyl-L-alpha-glutamyl-L-lysyl-L-glutaminyl-L-glutaminyl-L-alanyl-L-alanyl-L-asparagyl-L-asparagyl-L-arginyl-L-leucyl-L-leucyl-L-leucyl-L-alpha-aspartyl-L-threonyl-L-isoleucine; 11-D-Phenylalanine-12-L-histidine-11-40-sauvagine (11-40). Grade: ≥95%. CAS No. 220673-95-0. Molecular formula: C161H274N48O46S. Mole weight: 3650.29. | |
| Astressin | Astressin is a novel potent corticotropin releasing factor (CRF) antagonist. Astressin may be a useful tool to explore functional CRF-dependent physiological pathways in specific brain nuclei. Uses: Neuroprotective agents. Synonyms: (D-Phe12,Nle21·38,Glu30,Lys33)-CRF (12-41) (human, rat); H-D-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Glu(1)-Ala-His-Lys(1)-Asn-Arg-Lys-Leu-Nle-Glu-Ile-Ile-NH2. Grade: ≥95%. CAS No. 170809-51-5. Molecular formula: C161H269N49O42. Mole weight: 3563.16. | |
| Astressin | Astressin is a potent corticotropin releasing factor ( CRF ) antagonist. Uses: Scientific research. Group: Peptides. CAS No. 170809-51-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P0257. | |
| Astressin 2B | Astressin 2B is a selective and potent corticotropin-releasing factor receptor 2 (CRF2) antagonist with IC50 values of > 500 nM and 1.3 for CRF1 and CRF2 respectively. It antagonizes CRF2-mediated inhibition of gastric emptying. Synonyms: Cyclo(31-34)[D-Phe11,His12,C(α)MeLeu13,39,Nle17,Glu31,Lys34]Ac-Svg(8-40). Grade: >98%. CAS No. 681260-70-8. Molecular formula: C183H307N49O53. Mole weight: 4041.69. | |
| Astressin 2B TFA | Astressin 2B TFA is a selective and potent corticotropin-releasing factor receptor 2 (CRF2) antagonist with IC50 values of > 500 nM and 1.3 for CRF1 and CRF2 respectively. It antagonizes CRF2-mediated inhibition of gastric emptying. Grade: 98%. Molecular formula: C183H307N49O53.xC2HF3O2. Mole weight: 4041.69 (free base). | |
| Corticostatin 1 | Corticostatin 1 is from Oryctolagus cuniculus. It has microbicidal activity and inhibits corticotropin (ACTH) stimulated corticosterone production. Synonyms: Antiadrenocorticotropin peptide I. | |
| Corticostatin-6 | Corticostatin-6 is from Oryctolagus cuniculus. It has microbicidal activity and inhibits corticotropin (ACTH) stimulated corticosterone production. | |
| Corticostatin-related peptide LCRP | Corticostatin-related peptide LCRP is isolated from Petromyzon marinus. It may inhibit corticotropin (ACTH) stimulated steroidogenesis and the microbial actions of the corticostatins. | |
| Cortisol (HRP) | Cortisol is the most potent glucocorticoid produced by the human adrenal. It is synthesized from cholesterol and its production is stimulated by pituitary adrenocorticotropic hormone (ACTH) which is regulated by corticotropin releasing factor (CRF). ACTH and CRF secretions are inhibited by high cortisol levels in a negative feedback loop. In plasma a majority of cortisol is bound with high affinity to corticosteroid binding globulin (CBG or transcotin). Cortisol acts through specific intracellular receptors and affects numerous physiologic systems including immune function, glucose counter regulation, vascular tone, and bone metabolism. Group: Biochemicals. Grades: Purified. Pack Sizes: 500ul. US Biological Life Sciences. | Worldwide |
| CP 154526 hydrochloride | CP 154526 hydrochloride is a potent, brain-penetrant and selective corticotropin-releasing factor receptor 1 (CRF1) antagonist with a K i of 2.7 nM. CP 154526 hydrochloride shows selective for CRF1 over CRF2 (K i=>10 μM). CP 154526 hydrochloride has anxiolytic activities [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 257639-98-8. Pack Sizes: 5 mg. Product ID: HY-12129. | |
| CP-154526 Hydrochloride | A selective, non-peptide antagonist of corticotropin releasing factor receptors (CRF1). It blocks CRF-induced adenylate cyclase activation and attenuates activation of the HPA axis by CRF. It displayed anxiolytic-like activity in the rat elevated plus-maze test; brain penetrant. Group: Biochemicals. Alternative Names: N-Butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Hydrochloride. Grades: Highly Purified. CAS No. 257639-98-8. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| CRF (6-33) | CRF (6-33) has been found to be a CRFBP inhibitor peptide and could probably suppress body weight gain. Synonyms: Corticotropin-Releasing Factor (6-33). Grade: >98%. CAS No. 120066-38-8. Molecular formula: C141H231N41O43S. Mole weight: 3220.68. | |
| CRF (6-33) acetate | CRF (6-33) acetate has been found to be a corticotropin-releasing factor binding protein (CRFBP) inhibitor peptide and could probably suppress body weight gain. Synonyms: H-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-OH.CH3CO2H; L-isoleucyl-L-seryl-L-leucyl-L-alpha-aspartyl-L-leucyl-L-threonyl-L-phenylalanyl-L-histidyl-L-leucyl-L-leucyl-L-arginyl-L-alpha-glutamyl-L-valyl-L-leucyl-L-alpha-glutamyl-L-methionyl-L-alanyl-L-arginyl-L-alanyl-L-alpha-glutamyl-L-glutaminyl-L-leucyl-L-alanyl-L-glutaminyl-L-glutaminyl-L-alanyl-L-histidyl-L-serine acetate; 6-33-Human ACTH-releasing factor acetate; Rat corticotropin-releasing factor(6-33) acetate. Grade: ≥95%. Molecular formula: C143H235N41O45S. Mole weight: 3280.76. | |
| CRF, bovine | CRF, bovine is an effective agonist of CRF (Corticotropin-releasing factor) receptor. Synonyms: Corticotropin Releasing Factor bovine; H-Ser-Gln-Glu-D-Pro-D-Pro-Ile-Ser-Leu-Asp-Leu-aThr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-DL-Met-Thr-Lys-D-Ala-D-Asp-D-Gln-D-Leu-D-Ala-D-Gln-D-Gln-D-Ala-D-His-D-Asn-D-Asn-D-Arg-D-Lys-D-Leu-D-Leu-D-Asp-aIle-D-Ala-NH2; L-seryl-L-glutaminyl-L-alpha-glutamyl-D-prolyl-D-prolyl-L-isoleucyl-L-seryl-L-leucyl-L-alpha-aspartyl-L-leucyl-L-allothreonyl-L-phenylalanyl-L-histidyl-L-leucyl-L-leucyl-L-arginyl-L-alpha-glutamyl-L-valyl-L-leucyl-L-alpha-glutamyl-DL-methionyl-L-threonyl-L-lysyl-D-alanyl-D-alpha-aspartyl-D-glutaminyl-D-leucyl-D-alanyl-D-glutaminyl-D-glutaminyl-D-alanyl-D-histidyl-D-asparagyl-D-asparagyl-D-arginyl-D-lysyl-D-leucyl-D-leucyl-D-alpha-aspartyl-L-alloisoleucyl-D-alaninamide. Grade: 95%. CAS No. 92307-52-3. Molecular formula: C206H340N60O63S. Mole weight: 4697.33. | |
| CRF, bovine TFA | CRF, bovine TFA is an effective agonist of CRF (Corticotropin-releasing factor) receptor. Synonyms: Corticotropin Releasing Factor bovine (TFA); CRF Bovine Trifluoroacetate. Grade: >98%. Molecular formula: C206H340N60O63S.C2HF3O2. Mole weight: 4811.36. | |
| (D-Phe12,Nle21.38,α-Me-Leu37)-CRF (12-41) (human, rat) | (D-Phe12,Nle21.38,α-Me-Leu37)-CRF (12-41) (human, rat) is a potent and long-acting CRF antagonist. Synonyms: H-D-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-α-Me-Leu-Nle-Glu-Ile-Ile-NH2; D-Phenylalanyl-L-histidyl-L-leucyl-L-leucyl-L-arginyl-L-α-glutamyl-L-valyl-L-leucyl-L-α-glutamyl-L-norleucyl-L-alanyl-L-arginyl-L-alanyl-L-α-glutamyl-L-glutaminyl-L-leucyl-L-alanyl-L-glutaminyl-L-glutaminyl-L-alanyl-L-histidyl-L-seryl-L-asparaginyl-L-arginyl-L-lysyl-2-methyl-L-leucyl-L-norleucyl-L-α-glutamyl-L-isoleucyl-L-isoleucinamide; 12-41-Corticotropin-releasing factor (human), 12-D-phenylalanine-21-L-norleucine-37-(2-methyl-L-leucine)-38-L-norleucine-. Grade: ≥95%. CAS No. 150646-45-0. Molecular formula: C159H267N49O43. Mole weight: 3553.17. | |
| Emicerfont | Emicerfont is a Corticotropin releasing factor receptor 1 antagonist. It can block the CRF1 receptor and so reduce ACTH release. It has been investigated for the treatment of irritable bowel syndrome (IBS) and alcoholism. In Feb 2008, GlaxoSmithKline completed enrolment in its Phase-II trial for Irritable bowel syndrome in the US and Canada. Uses: Irritable bowel syndrome (ibs) and alcoholism. Synonyms: GW876008; 1-{1-[1-(4-Methoxy-2-methylphenyl)-6-methyl-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-4-yl]-1H-pyrazol-3-yl}imidazolidin-2-one; GW876008X; 2-Imidazolidinone, 1-[1-[2,3-dihydro-1-(4-methoxy-2-methylphenyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl]-1H-pyrazol-3-yl]-. Grade: 98%. CAS No. 786701-13-1. Molecular formula: C22H24N6O2. Mole weight: 404.47. | |
| Emicerfont | Emicerfont is a corticotropin-releasing factor type 1 ( CRF 1 ) receptor antagonist with an IC 50 of 66 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GW876008. CAS No. 786701-13-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14367. | |
| N-acetyl semax | N-acetyl semax is a modified fragment of the corticotropin hormone. Synonyms: L-Methionyl-L-α-glutamylhistidyl-L-phenylalanyl-L-prolylglycyl-L-proline, (Pro8,Gly9,Pro10)ACTH-(4-10). Grade: 98%. Molecular formula: C37H51N9O10S. Mole weight: 813.92. | |
| peptide α-N-acetyltransferase | Acetylates N-terminal alanine, serine, methionine and glutamate residues in a number of peptides and proteins, including β-endorphin, corticotropins and melanotropin. cf. EC 2.3.1.108 α-tubulin N-acetyltransferase. Group: Enzymes. Synonyms: β-endorphin acetyltransferase; peptide acetyltransferase; protein N-terminal acetyltransferase; NAT; Nα-acetyltransferase; amino-terminal amino acid-acetylating enzyme; acetyl-CoA:peptide α-N-acetyltransferase. Enzyme Commission Number: EC 2.3.1.88. CAS No. 116155-74-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2269; peptide α-N-acetyltransferase; EC 2.3.1.88; 116155-74-9; β-endorphin acetyltransferase; peptide acetyltransferase; protein N-terminal acetyltransferase; NAT; Nα-acetyltransferase; amino-terminal amino acid-acetylating enzyme; acetyl-CoA:peptide α-N-acetyltransferase. Cat No: EXWM-2269. |  |
| Pexacerfont | Pexacerfont is a selective corticotropin-releasing factor ( CRF 1 ) receptor antagonist with IC 50 of 6.1±0.6 nM for human CRF 1 receptor. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-562086. CAS No. 459856-18-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-12127. | |
| Phe(2)-nle(4)-acth(1-24) | ACTH (1-24) is a fragment of the ACTH hormone, which stimulates the adrenal cortex and the secretion of glucocorticoids such as cortisol. Synonyms: 2-Phenylalanyl-4-norleucine-acth(1-24); ACTH (1-24), phe(2)-nle(4)-; alpha1-24-Corticotropin, 2-L-phenylalanine-4-L-norleucine-; (Phe2,Nle4)-ACTH (1-24) (human, bovine, rat). CAS No. 97773-00-7. Molecular formula: C137H212N40O30. Mole weight: 2899.40. | |
| Pivagabine | Pivagabine (CXB 722) is a hydrophobic 4-aminobutyric acid derivative with neuromodulatory activity. Pivagabine penetrates the blood-brain barrier in rats. Pivagabine antagonizes the effects of foot shock on both GABAA receptor function and corticotropin-releasing factor (CRF) concentrations in rat brain [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CXB-722. CAS No. 69542-93-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-108295. | |
| Saikosaponin D | Saikosaponin D is extracted from the root of Bupleurum chinense DC. It protects against acetaminophen-induced hepatotoxicity by inhibiting NF-κB and STAT3 signaling. It possesses potent cytotoxicity against human hepatocellular carcinoma cells. It inhibits cell growth of human cancer cells by inducing apoptosis and blocking cell cycle progression in the G1 phase. It was found to stimulate corticotropin-releasing factor (CRF) gene expression and CRF release. Uses: Anti-inflammatory agents, non-steroidal. Synonyms: (3b,4a,16a)-13,28-Epoxy-16,23-dihydroxyoleana-11-en-3-y1 3-O-b-D-glucopyranosyl-b-D-fucoside; (3β,4α,16α)-13,28-Epoxy-16,23-dihydroxyolean-11-en-3-yl 6-deoxy-3-O-β-D-glucopyranosyl-β-D-galactopyranoside. Grade: >98%. CAS No. 20874-52-6. Molecular formula: C42H68O13. Mole weight: 780.98. | |
| Sauvagine | Sauvagine is a corticotropin-releasing factor (CRF) receptor agonist (Ki = 9.4, 9.9, and 3.8 nM for inhibition of 125I-[D-Tyr1]astressin binding to hCRF-R1, rCRF-R2a and mCRF-R2b, respectively). Synonyms: H-Pyr-Gly-Pro-Pro-Ile-Ser-Ile-Asp-Leu-Ser-Leu-Glu-Leu-Leu-Arg-Lys-Met-Ile-Glu-Ile-Glu-Lys-Gln-Glu-Lys-Glu-Lys-Gln-Gln-Ala-Ala-Asn-Asn-Arg-Leu-Leu-Leu-Asp-Thr-Ile-NH2. Grade: >96%. CAS No. 74434-59-6. Molecular formula: C202H346N56O63S. Mole weight: 4599.35. | |
| Seractide acetate | ACTH (1-39) is a potent agonist of melanocortin receptor 2 (MC2R) with an EC50 value of 57 pM in HeLa cells expressing the mouse receptor. Synonyms: 1-39-Corticotropin (human) (TFA); α(1-39) Corticotropin human (TFA); Acth, human (TFA); Adrenocorticotropic hormone, human (TFA); ACTH (1-39) (TFA); ACTH (1-39) trifluoroacetate salt; Adrenocorticotropic Hormone (ACTH) (1-39), human (TFA); Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe.TFA. Grade: >98%. CAS No. 12279-41-3. Molecular formula: C207H308N56O58S.C2HF3O2. Mole weight: 4655.16. | |
| Stresscopin (human) | Stresscopin is a specific endogenous ligand of the corticotropin-releasing hormone receptor type 2 (CRHR2) that maintains homeostasis after stress. Intraperitoneal injection of stresscopin can inhibit the formation of heat induced edema in anesthetized rats. It also reduces food intake and inhibits gastric emptying activity. Synonyms: SCP (human); H-Thr-Lys-Phe-Thr-Leu-Ser-Leu-Asp-Val-Pro-Thr-Asn-Ile-Met-Asn-Leu-Leu-Phe-Asn-Ile-Ala-Lys-Ala-Lys-Asn-Leu-Arg-Ala-Gln-Ala-Ala-Ala-Asn-Ala-His-Leu-Met-Ala-Gln-Ile-NH2. Grade: ≥95% by HPLC. CAS No. 352020-03-2. Molecular formula: C195H326N56O53S2. Mole weight: 4367.15. | |
| Urocortin II, human | Urocortin II (human), a new member of the corticotropin-releasing-factor (CRF) family, is a selective endogenous peptide agonist of type-2 corticotropin-releasing factor (CRF2) receptor. Molecular formula: C194H339N63O54S. Mole weight: 4450.28. | |
| Urocortin II (human) trifluoroacetate salt | Urocortin II is a neuropeptide hormone that is a member of the corticotropin-releasing factor (CRF) family. Urocortin II is a highly selective agonist of the CRF2 receptor and does not show affinity for the CRF binding protein. Synonyms: PD080645. Grade: ≥95%. CAS No. 398001-88-2. Molecular formula: C196H340F3N63O56S. Mole weight: 4564.23. | |
| Urocortin III, mouse | Urocortin III a neuropeptide hormone and a member of the corticotropin-releasing factor (CRF) family, is a highly selective agonist of the CRF2 receptor and does not show affinity for the CRF binding protein. Synonyms: STRESSCOPIN (3-40) (MOUSE). CAS No. 357952-10-4. Molecular formula: C186H312N52O52S2. Mole weight: 4172.97. | |
| Urocortin III, mouse TFA | Urocortin III, mouse TFA is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III preferentially binds and activates CRF-R2[1]. Urocortin III (Ucn3) is a known component of the behavioral stress response system. Urocortin III and CRF-R2 in the medial amygdala regulate complex social dynamics[2]. Uses: Scientific research. Group: Peptides. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1858A. | |
| Vasopressin | Vasopressin is a cyclic nonapeptide that is synthesized centrally in the hypothalamus. Vasopressin participates in the hypothalamic-pituitary-adrenal axis, and regulates pituitary corticotropin secretion by potentiating the stimulatory effects of corticotropin releasing factor. Vasopressin also can act as a neurotransmitter, exerting its action by binding to specific G protein-coupled receptors [1] [2] [3]. Uses: Scientific research. Group: Peptides. CAS No. 11000-17-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-B1811. | |
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