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| Product | Description | |
|---|---|---|
| 1, 3-Bis (methoxymethoxy) -5-[ (1E) -2-[4- (methoxymethoxy) phenyl]ethenyl]-benzene | 1, 3-Bis (methoxymethoxy) -5-[ (1E) -2-[4- (methoxymethoxy) phenyl]ethenyl]-benzene is a useful synthetic intermediate in the synthesis of Resveratrol Impurity B (H950990); an impurity of Resveratrol (R150000) which is a minor constituent of wine, correlated with serum lipid reduction and inhibition of platelet aggregation. Resveratrol is a specific inhibitor of COX-1 and also inhibits the hydroperoxidase activity of COX-1. It has been shown to inhibit events associated with tumor initiation, promotion and progression. Group: Biochemicals. Grades: Highly Purified. CAS No. 1414361-09-3. Pack Sizes: 1g, 10g. Molecular Formula: C20H24O6, Molecular Weight: 360.4. US Biological Life Sciences. |  Worldwide |
| 1-Propyl Etodolac | 1-Propyl Etodolac is an impurity in the synthesis of Etodolac (E933100), may have use in the treatment of myeloma. COX-1/COX-2/ β-catenin inhibitors, or anti-inflammatory agent. Group: Biochemicals. Alternative Names: 1-Ethyl-1,3,4,9-tetrahydro-8-(1-methylethyl)-Pyrano[3,4-b]indole-1-acetic Acid. Grades: Highly Purified. CAS No. 57816-83-8. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| 2,4,6-trichloro-N-phenylaniline | A Diclofenac impurity which is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively. Synonyms: 2,4,6-Trichlorodiphenylamine; Diphenylamine, 2,4,6-trichloro; Diclofenac Impurity 10. CAS No. 15362-44-4. Molecular formula: C12H8Cl3N. Mole weight: 272.56. |  |
| 2,6-Dichlorodiphenylamine | 2,6-Dichlorodiphenylamine is an analogue of Diclofenac Sodium (HY-15037) and has anti-Candida albicans activity. Diclofenac Sodium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: Solid. CAS No. 15307-93-4. Molecular formula: C13H12N2OS. Mole weight: 238.11. Purity: 0.9971. Canonical SMILES: ClC1=C(NC2=CC=CC=C2)C(Cl)=CC=C1. Product ID: ACM15307934. Alfa Chemistry ISO 9001:2015 Certified. Categories: 2,6-Dichloro-N-phenylaniline. |  |
| 2,6-Dichlorodiphenylamine | 2,6-Dichlorodiphenylamine is an analogue of Diclofenac Sodium (HY-15037) and has anti- Candida albicans activity. Diclofenac Sodium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC 50 s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 2,6-Dichloro-N-phenylaniline. CAS No. 15307-93-4. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-W012126. |  |
| 2-Phenoxylaniline | 2-Phenoxylaniline (Nimesulide EP Impurity C) is an impurity of Nimesulide (N477500) which is an antiinflammatory agent that preferentially inhibits COX-2 over COX-1. Group: Biochemicals. Grades: Highly Purified. CAS No. 2688-84-8. Pack Sizes: 5g, 25g. Molecular Formula: C12H11NO. US Biological Life Sciences. | Worldwide |
| 2'-Phenoxymethane sulfonanilide | 2'-Phenoxymethane sulfonanilide is a metabolite of nimesulide (N477500), which is an antiinflammatory agent. It preferentially inhibits COX-2 over COX-1 and suppresses chemical-induced carcinogenesis in mice and rats. Nimesulide also nhibits LPS-induced TNF-alpha production. Group: Biochemicals. Grades: Highly Purified. CAS No. 51765-51-6. Pack Sizes: 100mg, 1g. Molecular Formula: C13H13NO3S, Molecular Weight: 263.31. US Biological Life Sciences. | Worldwide |
| 2-Phenylthio-5-propionylphenylacetic Acid | 2-Phenylthio-5-propionylphenylacetic Acid is a useful synthetic intermediate in the synthesis of Zaltoprofen (Z146000); an inhibitor of Cox-1 and Cox-2. Zaltoprofen preferentially inhibits Cox-2. Group: Biochemicals. Grades: Highly Purified. CAS No. 103918-73-6. Pack Sizes: 1g, 10g. Molecular Formula: C17H16O3S. US Biological Life Sciences. | Worldwide |
| 3-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-5-(phenylmethoxy)-phenol | 3-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-5-(phenylmethoxy)-phenol is the impurity C of Resveratrol (R150000); a minor constituent of wine, correlated with serum lipid reduction and inhibition of platelet aggregation. Resveratrol is a specific inhibitor of COX-1 and also inhibits the hydroperoxidase activity of COX-1. It has been shown to inhibit events associated with tumor initiation, promotion and progression. Group: Biochemicals. Grades: Highly Purified. CAS No. 678149-02-5. Pack Sizes: 5mg, 50mg. Molecular Formula: C21H18O3, Molecular Weight: 318.37. US Biological Life Sciences. | Worldwide |
| 3-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-5-(phenylmethoxy)-phenol-d7 | 3-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-5-(phenylmethoxy)-phenol-d7 is the isotope labelled analog of 3-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-5-(phenylmethoxy)-phenol (H950995); the impurity C of Resveratrol (R150000) which is a minor constituent of wine, correlated with serum lipid reduction and inhibition of platelet aggregation. Resveratrol is a specific inhibitor of COX-1 and also inhibits the hydroperoxidase activity of COX-1. It has been shown to inhibit events associated with tumor initiation, promotion and progression. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C21H11D7O3, Molecular Weight: 325.41. US Biological Life Sciences. | Worldwide |
| 3-(7-Ethyl-1H-indol-3-yl)-3-(7-Ethyl-3-(2-Hydroxyethyl)-1H-indol-2-yl)Pentanoic Acid (Etodolac Impurity) | 3-(7-Ethyl-1H-indol-3-yl)-3-(7-ethyl-3-(2-Hydroxyethyl)-1H-indol-2-yl)Pentanoic Acid is an impurity in the synthesis of Etodolac (E933100). Like other Etodolac impurities (P835255) may have use in the treatment of myeloma. COX-1/COX-2/ β-catenin inhibitors. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C27H32N2O3, Molecular Weight: 432.55. US Biological Life Sciences. | Worldwide |
| 4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone | 4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone exhibits COX-1 and COX-2 inhibitory activity [1]. Uses: Scientific research. Group: Natural products. CAS No. 151752-08-8. Pack Sizes: 25 mg; 1 mg; 5 mg; 10 mg. Product ID: HY-N8184. | |
| 4-Methoxy Lornoxicam | 4-Methoxy Lornoxicam is one of lornoxicam impurities. Lornoxicam is a non-steroidal COX-1/COX-2 inhibitor and a non-steroidal anti-inflammatory drug (NSAID), with analgesic, anti-pyretic, anti-thrombotic and anti-inflammatory activities. Grades: 98%. Molecular formula: C14H12ClN3O4S2. Mole weight: 385.85. | |
| 5,6-Epoxyeicosatrienoic acid | 5,6-Epoxyeicosatrienoic acid (5,6-EET; (±)5,6-EpETrE) is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. In solution, 5,6-Epoxyeicosatrienoic acid degrades into 5,6-DiHET and 5,6-δ-lactone, which can be converted to 5,6-DiHET and quantified by GC-MS. In neuroendocrine cells, such as the anterior pituitary and pancreatic islets, 5,6-Epoxyeicosatrienoic acid has been implicated in the mobilization of calcium and hormone secretion. 5,6-Epoxyeicosatrienoic acid is an inhibitor of T-type voltage-gated calcium channels (Cav3) that inhibits isoforms Cav3.1, Cav3.2 ( IC 50 =0.54 μM), and Cav3. and decreases nifedipine-resistant phenylephrine-induced vasoconstriction in isolated mouse mesenteric arteries via Cav3.2 blockade when used at a concentration of 3 μM. In addition, it is a substrate of COX-1 and COX-2. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 5,6-EET; (±)5,6-EpETrE. CAS No. 87173-80-6. Pack Sizes: 25 μg (312.04 μM * 250 μL in Ethanol); 50 μg (312.04 μM * 500 μL in Ethanol); 100 μg (312.04 μM * 1 mL in Ethanol). Product ID: HY-132184. | |
| 5-Hydroxy Lornoxicam | 5-Hydroxy Lornoxicam is one of lornoxicam metabolites. Lornoxicam is a non-steroidal COX-1/COX-2 inhibitor and a non-steroidal anti-inflammatory drug (NSAID), with analgesic, anti-pyretic, anti-thrombotic and anti-inflammatory activities. Synonyms: 6-Chloro-4-hydroxy-N-(5-hydroxy-2-pyridinyl)-2-methyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide 1,1-Dioxide; 2H-Thieno(2,3-e)-1,2-thiazine-3-carboxamide, 6-chloro-4-hydroxy-N-(5-hydroxy-2-pyridinyl)-2-methyl-, 1,1-dioxide. Grades: 98%. CAS No. 123252-96-0. Molecular formula: C13H10ClN3O5S2. Mole weight: 387.82. | |
| 7-(Trifluoromethyl)1H-indole-2,3-dione | An indole derivative as inhibitor of COX-1, COX-2, and β-catenin. Useful in the treatment of diseases such as: lung cancer, diabetes and Alzheimer's disease. Group: Biochemicals. Alternative Names: 7- (Trifluoromethyl) isatin. Grades: Highly Purified. CAS No. 391-12-8. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| 7-(Trifluoromethyl)-1H-indole-2,3-dione-d2 | 7-(Trifluoromethyl)1H-indole-2,3-dione-d2 is a labelled 7-(Trifluoromethyl)1H-indole-2,3-dione (T791300), an inhibitor of COX-1, COX-2, and β-catenin. Useful in the treatment of diseases such as: lung cancer, diabetes and Alzheimer's disease. Group: Biochemicals. Alternative Names: 7- (Trifluoromethyl) isatin-d2. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Allyl Bromide (Stabilized with Propylene Oxide) | Allyl Bromide is used as a reagent in the synthesis of Resveratrol derivatives. Resveratrol (R150000) is a minor constituent of wine, correlated with serum lipid reduction and inhibition of platelet aggregation. Resveratrol is a specific inhibitor of COX-1, and it also inhibits the hydroperoxidase activity of COX-1. It has been shown to inhibit events associated with tumor initiation, promotion and progression. Group: Biochemicals. Alternative Names: 3-Bromo-1-propene; 1-Bromo-2-propene; 2-Propenyl Bromide; 3-Bromo-1-propene; 3-Bromopropene; 3-Bromopropylene; Allyl Bromide; NSC 7596. Grades: Highly Purified. CAS No. 106-95-6. Pack Sizes: 10g. US Biological Life Sciences. | Worldwide |
| Allyl-d5 Bromide | Isotope labelled Allyl Bromide is used as a reagent in the synthesis of Resveratrol derivatives. Resveratrol (R150000) is a minor constituent of wine, correlated with serum lipid reduction and inhibition of platelet aggregation. Resveratrol is a specific inhibitor of COX-1, and it also inhibits the hydroperoxidase activity of COX-1. It has been shown to inhibit events associated with tumor initiation, promotion and progression. Group: Biochemicals. Alternative Names: 3-Bromo-1-propene-d5; 1-Bromo-2-propene-d5; 2-Propenyl Bromide-d5; 3-Bromo-1-propene-d5; 3-Bromopropene-d5; 3-Bromopropylene-d5; Allyl Bromide-d5; NSC 7596-d5. Grades: Highly Purified. CAS No. 102910-37-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Aspirin | Aspirin (Acetylsalicylic Acid) is an orally active, potent and irreversible inhibitor of cyclooxygenase COX-1 and COX-2 , with IC 50 values of 5 and 210 μg/mL, respectively. Aspirin induces apoptosis. Aspirin inhibits the activation of NF-κB. Aspirin also inhibits platelet prostaglandin synthetase , and can prevent coronary artery and cerebrovascular thrombosis [1] [2] [3] [4] [5] [6]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Acetylsalicylic Acid; ASA. CAS No. 50-78-2. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-14654. | |
| Aspirin (Standard) | Aspirin (Standard) is the analytical standard of Aspirin. This product is intended for research and analytical applications. Aspirin (Acetylsalicylic Acid) is an orally active, potent and irreversible inhibitor of cyclooxygenase COX-1 and COX-2 , with IC 50 values of 5 and 210 μg/mL, respectively. Aspirin induces apoptosis. Aspirin inhibits the activation of NF-κB. Aspirin also inhibits platelet prostaglandin synthetase , and can prevent coronary artery and cerebrovascular thrombosis [1] [2] [3] [4] [5] [6]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Acetylsalicylic Acid(Standard); ASA (Standard). CAS No. 50-78-2. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-14654R. | |
| Bromfenac sodium | Bromfenac sodium is a potent and orally active inhibitor of COX , with IC 50 s of 5.56 and 7.45 nM for COX-1 and COX-2 , respectively. Bromfenac sodium can be used in ocular inflammation research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 91714-93-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-B1888A. | |
| Bromfenac sodium hydrate | Bromfenac sodium hydrate (Bromfenac monosodium salt sesquihydrate) is a potent and orally active inhibitor of COX , with IC 50 s of 5.56 and 7.45 nM for COX-1 and COX-2 , respectively. Bromfenac sodium hydrate can be used in ocular inflammation research [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Bromfenac monosodium salt sesquihydrate. CAS No. 120638-55-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-B1888B. | |
| Bromfenac Sodium Salt | Bromfenac Sodium Salt is a potent inhibitor of both COX-1 and COX-2. Uses: Anti-inflammatory agents, non-steroidal. Synonyms: AHR 10282R; AHR10282R; AHR-10282R. Grades: > 95%. CAS No. 91714-93-1. Molecular formula: C15H11BrNO3.Na. Mole weight: 356.15. | |
| BW 755C | Constitutive cyclooxygenase (COX-1) is present in cells under physiological conditions, whereas COX-2 is induced by some cytokines, mitogens, and endotoxin in pathological conditions, such as inflammation. Since 5-lipoxygenase (5-LO) oxidizes arachidonic acid to 5-hydroperoxyeicosatetraenoic acid. BW 755C is a dual inhibitor of 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathways. It inhibits 5-LO with IC50s of 0.75 μM, COX-1 with IC50s of 0.65 μg/ml, and COX-2 with IC50s of 1.2 μg/ml. BW 755C may also inhibit other LO pathways in vivo. Uses: Anti-inflammatory agents, non-steroidal. Synonyms: BW755C; BW-755C; 1H-Pyrazol-3-amine, 4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-; 4,5-Dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine; 1-(3-Trifluoromethylphenyl)-4,5-dihydro-1H-pyrazol-3-amine; 3-Amino-1-[3-(trifluoromethyl)phenyl]-2-pyrazoline; 3-Amino-1-[3-(trifluoromethyl)phenyl]pyrazoline; 3-Amino-1-[m-(trifluoromethyl)phenyl]-2-pyrazoline; Compound BW 755C. Grades: ≥95%. CAS No. 66000-40-6. Molecular formula: C10H10F3N3. Mole weight: 229.20. | |
| Carprofen | Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor, with IC 50 s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively. Uses: Scientific research. Group: Natural products. CAS No. 53716-49-7. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-B1227. | |
| Catechin | Catechin ((+)-Catechin) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Catechuic Acid. Product Category: Inhibitors. CAS No. 154-23-4. Molecular formula: C15H14O6. Mole weight: 290.27. Purity: 0.98. Canonical SMILES: C1[C@@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)O. Product ID: ACM154234. Alfa Chemistry ISO 9001:2015 Certified. | |
| Catechin | Catechin ((+)-Catechin) inhibits cyclooxygenase-1 ( COX-1 ) with an IC 50 of 1.4 μM. Uses: Scientific research. Group: Natural products. Alternative Names: (+)-Catechin; Cianidanol; Catechuic acid. CAS No. 154-23-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-N0898. | |
| (-)-Catechin | (-)-Catechin is Catechin's one kind of different structure. Catechin inhibitory enzyme-1 (COX-1), IC50 ? 1.4 μM. (-)-Catechin promotes hBM-MSC adipose cell differentiation, increases fat cell differentiation, and PPARγ level [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: (-)-Cianidanol; (-)-Catechuic acid. CAS No. 18829-70-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0898A. | |
| (±)-Catechin | (±)-Catechin (rel-Cianidanol) This is a green tea polyester. Catechin possesses anti-cancer activity, which has led to its demise. (±)-Catechin ????forms (+)-Catechin and its reflection body (-)-Catechin. (+)-Catechin inhibitory environment-1 (COX-1) IC 50 ? 1.4 μM. (-)-Catechin has the effect of promoting hBM-MSC adipose cell differentiation, increasing adipose tissue, and PPARγ horizontal. (±)-Catechin has anti-diabetic, anti-hypertrophic, anti-diabetic, anti-cardiovascular, anti-infective, and liver-protecting effects. Uses: Scientific research. Group: Natural products. Alternative Names: rel-Cianidanol; rel-Catechuic acid. CAS No. 7295-85-4. Pack Sizes: 10 mM * 1 mL; 100 mg; 250 mg. Product ID: HY-B1890. | |
| (-)-Catechin gallate | (-)-Catechin gallate is a minor constituent in green tea catechins. (-)-Catechin gallate inhibits the activity of COX-1 and COX-2 enzymes. Uses: Scientific research. Group: Natural products. Alternative Names: (-)-Catechin 3-gallate; (-)-Catechin 3-O-gallate. CAS No. 130405-40-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-N0356. | |
| (+)-Catechin hydrate | (+)-Catechin hydrate inhibits cyclooxygenase-1 ( COX-1 ) with an IC 50 of 1.4 μM. Uses: Scientific research. Group: Natural products. CAS No. 225937-10-0. Pack Sizes: 100 mg. Product ID: HY-N0355. | |
| CAY10589 | CAY10589 is a dual inhibitor of mPGES-1 with IC50 of 1.3 μM and 5-LO with IC50 of 1.0 μM. It effectively inhibits PGE2 and LT synthesis in both cell free and intact cell assays. CAY10589 has minor effects on COX-1 and COX-2, inhibiting these enzymes 34% and 38.8%, respectively. Synonyms: CAY 10589; CAY-10589. Grades: ≥98%. CAS No. 1077626-52-8. Molecular formula: C25H28ClN3O2S. Mole weight: 470. | |
| Celecoxib (Celebrex, 4-[5-(4-Methylphenyl)-3-trifluoromethyl)-1H-pyrazol-yl]benzenesulfonamide) | Celecoxib is a highly selective COX-2 inhibitor and primarily inhibits prostaglandin production. Celecoxib is approximately 7.6-fold more selective for COX-2 inhibition over COX-1. This specificity allows celecoxib to reduce inflammation and pain while minimizing gastrointestinal adverse drug reactions (e.g. stomach ulcers) that are common with non-selective non-steroidal anti-inflammatory drugs (NSAIDs). Group: Biochemicals. Alternative Names: Celecoxib, 4-[5-(4-Methylphenyl)-3-trifluoromethyl)-1H-pyrazol-yl]benzenesulfonamide. Grades: Highly Purified. CAS No. 169590-42-5. Pack Sizes: 300mg, 500mg, 1g, 5g. Molecular Formula: C17H14F3N3O2S, Molecular Weight: 381.37. US Biological Life Sciences. | Worldwide |
| Chebulagic acid | Chebulagic acid is a polyphenol and tannin that has been found in T. chebula and has diverse biological activities. It is an inhibitor of COX-1, COX-2, and 5-lipoxygenase (5-LO; IC50s = 15, 0.92, and 2.1 μM, respectively) as well as α-glucosidase and 15-LO (IC50s = 0.05 and 24.9 μM, respectively). Chebulagic acid inhibit the LPS-induced upregulation of TNF-α and IL-1β in a dose- and time-dependent manner. And it can also inhibit the production of NO, prostaglandin E2 (PGE2), and reactive oxygen species (ROS), and nuclear translocation of NF-κB in RAW 264.7 macrophages in a concentration-dependent manner. Chebulagic acid also show a protective effect against 1-methyl-4-phenylpyridinium (MPP+) - induce cytotoxicity which mimics the pathological symptom of Parkinson's disease. Uses: Topoisomerase i inhibitors. Synonyms: β-D-glucopyranose; Cyclic 3,6-[(1R)-4,4',5,5',6,6'-hexahydroxy[1,1'-biphenyl]-2,2'-dicarboxylate] 1-(3,4,5-trihydroxybenzoate); Cyclic 2?2:4?1-ester with (2S)-2-[(3S,4S)-5-carboxy-3,4-dihydro-3,7,8-trihydroxy-2-oxo-2H-1-benzopyran-4-yl]butanedioic acid. Grades: ≥98%. CAS No. 23094-71-5. Molecular formula: C41H30O27. Mole weight: 954.66. | |
| Chlorotrianisene | Chlorotrianisene is a long-acting non-steroidal estrogen and an orally active estrogen receptor modulator. Chlorotrianisene exhibits antiestrogenic activity. Chlorotrianisene potently inhibits the enzyme COX-1 and inhibits platelet aggregation in whole blood [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 569-57-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-B2158. | |
| cis-Resveratrol | Minor constituent of wine, correlated with serum lipid reduction and inhibition of platelet aggregation. Resveratrol is a specific inhibitor of COX-1, and it also inhibits the hydroperoxidase activity of COX-1. It has been shown to inhibit events associated with tumor initiation, promotion and progression. Group: Biochemicals. Alternative Names: 5-[(1Z)-2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol; cis-3,4',5-Trihydroxystilbene; Z-5-[2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol; (Z)-Resveratrol. Grades: Highly Purified. CAS No. 61434-67-1. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Cudraflavone B | Cudraflavone B is a prenylated flavonoid with anti-inflammatory and anti-tumor properties. Cudraflavone B is also a dual inhibitor of COX-1 and COX-2. Cudraflavone B blocks the translocation of nuclear factor κB (NF-κB) from the cytoplasm to the nucleus in macrophages. Thus, Cudraflavone B inhibits tumor necrosis factor α (TNFα) gene expression and secretion. Cudraflavone B also triggers the mitochondrial apoptotic pathway, activates NF-κB, the MAPK p38, and ERK, and induced the expression of SIRT1. Thus Cudraflavone B inhibits the growth of human oral squamous cell carcinoma cells. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: Powder. CAS No. 19275-49-1. Molecular formula: C25H24O6. Mole weight: 420.45. Purity: 0.98. IUPACName: 8-(2,4-dihydroxyphenyl)-5-hydroxy-2,2-dimethyl-7-(3-methylbut-2-enyl)pyrano[3,2-g]chromen-6-one. Canonical SMILES: CC(=CCC1=C(OC2=CC3=C(C=CC(O3)(C)C)C(=C2C1=O)O)C4=C(C=C(C=C4)O)O)C. Product ID: ACM19275491. Alfa Chemistry ISO 9001:2015 Certified. | |
| Cyclooxygenase 1 from Human, Recombinant | COX-1 catalyzes the conversion of arachidonic acid to prostaglandin H2 (the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins). It is involved in the homeostatic role of eicosanoids and constitutively almost all animal tissues. Has an apparent KM of 8.3 μM for arachidonic acid. Group: Enzymes. Synonyms: COX-1; Constitutive cyclooxygenase; Prostaglandin H synthase 1; Prostaglandin endoperoxide synthase; EC 1.14.99.1; prostaglandin synthase; prostaglandin G/H synthase; (PG)H synthase; PG synthetase; prostaglandin synthetase; fatty acid cyclooxygenase; prostaglandin endoperoxide synthetase. COX-1. Mole weight: ~70 kDa. Activity: >20,000 units/mg. Stability: > 6 months. Storage: -80°C (as supplied); avoid freeze/thaw cycles by aliquoting protein. Form: 80 mM Tris, pH 8.0, containing 0.1% polysorbate 20, 300 uM DDC, and 10% glycerol. Source: Sf21 cells. Species: Human. COX-1; Constitutive cyclooxygenase; Prostaglandin H synthase 1; Prostaglandin endoperoxide synthase; EC 1.14.99.1; prostaglandin synthase; prostaglandin G/H synthase; (PG)H synthase; PG synthetase; prostaglandin synthetase; fatty acid cyclooxygenase; prostaglandin endoperoxide synthetase. Cat No: NATE-1237. |  |
| Diclofenac | A non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively. Synonyms: Voltaren; Ecofenac; Solaraze. Grades: > 95%. CAS No. 15307-86-5. Molecular formula: C14H11Cl2NO2. Mole weight: 296.15. | |
| Diclofenac | Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC 50 s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells [1] , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively [2]. Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 15307-86-5. Pack Sizes: 10 mM * 1 mL; 500 mg; 5 g; 10 g. Product ID: HY-15036. | |
| Diclofenac-13C6 | Diclofenac- 13 C 6 is the 13 C 6 labeled Diclofenac. Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade. Uses: Scientific research. Group: Isotope-labeled compounds. CAS No. 1261393-71-8. Pack Sizes: 1 mg. Product ID: HY-15036S1. | |
| Diclofenac amide | Diclofenac amide is a prodrug for Diclofenac sodium (HY-15037). Diclofenac amide is an orally active inhibitor for COX-1/2 , that inhibits the production of prostaglandins (PG) and thromboxanes (TX). Diclofenac amide exhibits anti-inflammatory efficacy in Carrageenan (HY-125474)-induced rat paw edema model without causing gastric ulcer (300 μmol/kg) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 15362-40-0. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-134521. | |
| Diclofenac-d4 | Diclofenac-d 4 is the deuterium labeled Diclofenac. Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3]. Uses: Scientific research. Group: Isotope-labeled compounds. CAS No. 153466-65-0. Pack Sizes: 1 mg. Product ID: HY-15036S. | |
| Diclofenac-d4 sodium | Diclofenac-d 4 (sodium) is the deuterium labeled Diclofenac sodium. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3]. Uses: Scientific research. Group: Isotope-labeled compounds. CAS No. 154523-54-3. Pack Sizes: 1 mg. Product ID: HY-15037S1. | |
| Diclofenac diethylamine | Diclofenac diethylamine is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC 50 s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells [1] , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively [2]. Diclofenac diethylamine induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 78213-16-8. Pack Sizes: 10 mM * 1 mL; 500 mg; 5 g; 10 g. Product ID: HY-15036A. | |
| Diclofenac potassium | Diclofenac potassium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC 50 s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells [1] , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively [2]. Diclofenac potassium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 15307-81-0. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 250 mg. Product ID: HY-15038. | |
| Diclofenac Sodium | Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC 50 s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells [1] , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively [2]. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GP 45840. CAS No. 15307-79-6. Pack Sizes: 10 mM * 1 mL; 500 mg; 5 g. Product ID: HY-15037. | |
| Diclofenac (Sodium) (Standard) | Diclofenac (Sodium) (Standard) is the analytical standard of Diclofenac (Sodium). This product is intended for research and analytical applications. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC 50 s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells [1] , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively [2]. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GP 45840 (Standard). CAS No. 15307-79-6. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-15037R. | |
| Dipyrone | Dipyrone is a non-steroidal anti-inflammatory drug that, when coadministered with morphine, potentiates its antinociceptive action and delays the development of tolerance. Dipyrone is a relatively selective inhibitor of cyclooxygenase-3 (COX-3), with lower activity against COX-1 and no activity against COX-2. Dipyrone blocks PGE2-induced hyperalgesia in several models. Group: Biochemicals. Alternative Names: 1- [ (2, 3-Dihydro-1, 5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl) methylamino] methanesulfonic Acid Sodium Salt; (Antipyrinyl methyl amino) methanesulfonic Acid Sodium Salt; ARPF; Algocalmin; Algopyrin; Anador; Analgin; Analgine; Andolor; Conmel; Diprofarn; Gifaril; Lisador; Metamizol; Metamizole; Metamizole Sodium; Metamizole Sodium Salt; Metapyrin; Methamizole Sodium; Methampyrone; Methylmelubrin; Metilon; Narone; Sulpin; Sulpyrin; Sulpyrine. Grades: Highly Purified. CAS No. 68-89-3. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| Enflicoxib | Enflicoxib (E 6087) is a nonsteroidal anti-inflammatory compound that selectively inhibits cyclooxygenase-2 ( COX-2 ). Enflicoxib does not inhibit cyclooxygenase-1 (COX-1). E-6087 shows anti-inflammatory, analgesic and antipyretic activities in animal models [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: E 6087. CAS No. 251442-94-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19384. | |
| (-)-Epicatechin | (-)-Epicatechin inhibits cyclooxygenase-1 ( COX-1 ) with an IC 50 of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB. Uses: Scientific research. Group: Natural products. Alternative Names: (-)-Epicatechol; Epicatechin; epi-Catechin. CAS No. 490-46-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-N0001. | |
| (-)-Epicatechin gallate | (-)-Epicatechin gallate (Epicatechin gallate) inhibits cyclooxygenase-1 ( COX-1 ) with an IC 50 of 7.5 μM. Uses: Scientific research. Group: Natural products. Alternative Names: Epicatechin gallate; ECG; (-)-Epicatechin 3-O-gallate. CAS No. 1257-08-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0002. | |
| (-)-Epicatechin Gallate | (-)-Epicatechin gallate (Epicatechin gallate) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 7.5 μM. Uses: Designed for use in research and industrial production. Additional or Alternative Names: (2R)-2α-(3,4-Dihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3β,5,7-triol 3-(3,4,5-trihydroxybenzoate). Product Category: Inhibitors. Appearance: White powder. CAS No. 1257-08-5. Molecular formula: C22H18O10. Mole weight: 442.37. Purity: 0.98. IUPACName: [(2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate. Canonical SMILES: C1[C@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O. Density: 1.80±0.1 g/ml. Product ID: ACM1257085. Alfa Chemistry ISO 9001:2015 Certified. | |
| (-)-Epicatechin gallate (Standard) | (-)-Epicatechin gallate (Standard) is the analytical standard of (-)-Epicatechin gallate. This product is intended for research and analytical applications. (-)-Epicatechin gallate (Epicatechin gallate) inhibits cyclooxygenase-1 ( COX-1 ) with an IC 50 of 7.5 μM. Uses: Scientific research. Group: Natural products. Alternative Names: Epicatechin gallate(Standard); ECG(Standard); (-)-Epicatechin 3-O-gallate (Standard). CAS No. 1257-08-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0002R. | |
| (-)-Epicatechin (Standard) | (-)-Epicatechin (Standard) is the analytical standard of (-)-Epicatechin. This product is intended for research and analytical applications. (-)-Epicatechin inhibits cyclooxygenase-1 ( COX-1 ) with an IC 50 of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB. Uses: Scientific research. Group: Natural products. Alternative Names: (-)-Epicatechol(Standard); Epicatechin(Standard); epi-Catechin (Standard). CAS No. 490-46-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0001R. | |
| Etoricoxib | Etoricoxib (MK-0663) is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC 50 s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK-0663; L-791456. CAS No. 202409-33-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15321. | |
| Fenbufen | Fenbufen (CL-82204) is an orally active non-steroidal anti-inflammatory drug (NSAID) , with analgetic and antipyretic effects. Fenbufen has potent activity in a variety of animal model, including carageenin edema, UV erythema and adjuvant arthritis. Fenbufen has inhibitory activities against COX-1 and COX-2 with IC 50 s of 3.9 μM and 8.1 μM, respectively. Fenbufen is a caspases (caspase-1, 3, 4, 5, 9) inhibitor [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CL-82204. CAS No. 36330-85-5. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-B1138. | |
| Firocoxib | Firocoxib (ML 1785713) is a potent, selective and orally active COX-2 inhibitor with an IC 50 of 0.13 μM. Firocoxib shows 58-fold more selective for COX-2 than COX-1 (IC 50 of 7.5 μM). Firocoxib has anti-inflammatory effects [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ML 1785713. CAS No. 189954-96-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-14670. | |
| Flunixin meglumine | Flunixin meglumine is a cyclooxygenase ( COX ) inhibitor with IC 50 values of 0.55 and 3.24 μM for COX-1 and COX-2, respectively. Flunixin meglumine shows anti-inflammatory effects [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 42461-84-7. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-B0386. | |
| Flunixin (meglumine) (Standard) | Flunixin (meglumine) (Standard) is the analytical standard of Flunixin (meglumine). This product is intended for research and analytical applications. Flunixin meglumine is a cyclooxygenase (COX) inhibitor with IC50 values of 0.55 and 3.24 μM for COX-1 and COX-2, respectively. Flunixin meglumine shows anti-inflammatory effects [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 42461-84-7. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0386R. | |
| FR122047 | FR122047 (hydrochloride) is a selective and oral active inhibitor of COX-1 with an IC 50 of 28 nM. FR122047 hydrochloride has antiplatelet, analgesic and anti-inflammatory effects in vivo [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 130717-51-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-103386. | |
| FR 122047 hydrochloride | FR-122047 is a selective cyclooxygenase-1 (COX-1) inhibitor with IC50 values is 0.028μM for COX-1 and 65 μM for COX-2. FR-122047 displays 2300 fold greater selectivity towards inhibition of COX-1 over COX-2. It shows analgesic, anti-platelet and anti-inflammatory properties. No development was reported for the treatment of Pain, Rheumatoid arthritis and Thrombosis. Uses: Pain; rheumatoid arthritis; thrombosis. Synonyms: FR 122047 hydrochloride;1-[[4,5-bis-(4-Methoxyphenyl)-2-thiazolyl]carbonyl]-4-methylpiperazine hydrochloride. Grades: >98 %. CAS No. 130717-51-0. Molecular formula: C23H25N3O3S.HCl. Mole weight: 459.99. | |
| FR122047 hydrochloride hydrate | FR122047 is a selective inhibitor of COX-1 with an IC50 value of 0.028 μM. Synonyms: 1-[[4,5-bis(4-methoxyphenyl)-2-thiazolyl]carbonyl]-4-methyl-piperazine, monohydrochloride, monohydrate. Grades: ≥98%. Molecular formula: C23H25N3O3S·HCl·H2O. Mole weight: 478. | |
| Gnetol | Gnetol is a phenolic compound isolated from the root of Gnetum montanum. Gnetol potently inhibits COX-1 (IC50 of 0.78 μM) and HDAC. Gnetol is a potent tyrosinase inhibitor with an IC50 of 4.5 μM for murine tyrosinase and suppresses melanin biosynthesis. Gnetol has antioxidant, antiproliferative, anticancer and hepatoprotective activity. Gnetol also possesses concentration-dependent α-Amylase, α-glucosidase, and adipogenesis activities. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 2-[(1E)-2-(3,5-Dihydroxyphenyl)ethenyl]-1,3-benzenediol;Gnetol. Product Category: Inhibitors. Appearance: Powder. CAS No. 86361-55-9. Molecular formula: C14H12O4. Mole weight: 244.2. Purity: 0.98. IUPACName: 2-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,3-diol. Canonical SMILES: C1=CC(=C(C(=C1)O)C=CC2=CC(=CC(=C2)O)O)O. Product ID: ACM86361559. Alfa Chemistry ISO 9001:2015 Certified. Categories: Gnetophyta. | |
| Guaiacin | Guaiacin is a lignan isolated from the leaves of Guaiacum officinale. Guaiacin inhibits COX-1 and COX-2 leading to the reduction of inflammations. Synonyms: (6R,7S,8S)-8-(4-hydroxy-3-methoxyphenyl)-3-methoxy-6,7-dimethyl-5,6,7,8-tetrahydronaphthalen-2-ol. Grades: >98%. CAS No. 36531-08-5. Molecular formula: C20H24O4. Mole weight: 328.408. | |
| Harpagoside | Harpagoside can be obtained by Harpagophytum procumbens , which has anti-inflammatory, anti-cancer, protective activity, and efficacy. Harpagoside has an inhibitory effect on COX-1 and COX-2 active, and suppresses NO production. Harpagoside inhibits HepG2 cell lipid polysaccharide, which is a protein that is expressed horizontally and selectively, and has anti-inflammatory and latent pain effects. Harpagoside has the ability to protect the body, and has a degenerative effect on the β-oxidation (Aβ) [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 19210-12-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 20 mg. Product ID: HY-N0396. | |
| Hexahydrocurcumin | Hexahydrocurcumin is one of the major metabolites of curcumin and a selective, orally active COX-2 inhibitor. Hexahydrocurcumin is inactive against COX-1. Hexahydrocurcumin has antioxidant, anticancer and anti-inflammatory activities [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 36062-05-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0929. | |
| Ibuprofen | Ibuprofen ((±)-Ibuprofen) is a potent, orally active, selective COX-1 inhibitor with an IC 50 value of 13 μM. Ibuprofen inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen ((±)-Ibuprofen) can be used in the research of pain, swelling, inflammation, infection, immunology, cancers [1] [2] [5] [8]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (±)-Ibuprofen. CAS No. 15687-27-1. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-78131. | |
| Ibuprofen | Ibuprofen is an inhibitor of COX-1 and COX-2 with IC50 of 13 μM and 370 μM, respectively. Synonyms: α-methyl-4-(2-methylpropyl)?-benzeneacetic acid. CAS No. 15687-27-1. Molecular formula: C13H18O2. Mole weight: 206.28. | |
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