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| Product | Description | |
|---|---|---|
| CXCR4 antagonist 1 | CXCR4 antagonist 1 is a potent CXCR4 antagonist with anti-HIV activity. Synonyms: 1,4-Butanediamine, N4-[[4-[[(1H-imidazol-2-ylmethyl)[(1-methyl-1H-imidazol-2-yl)methyl]amino]methyl]phenyl]methyl]-N1,N1-dipropyl-; N-(4-{[(1H-imidazol-2-ylmethyl)-(1-methyl-1H-imidazol-2-ylmethyl)-amino]-methyl}-benzyl)-N',N'-dipropyl-butane-1,4-diamine. Grade: ≥98% (HPLC). CAS No. 675135-69-0. Molecular formula: C27H43N7. Mole weight: 465.68. |  |
| CXCR4 antagonist 2 | CXCR4 antagonist 2 is an antagonist of CXCR4 with an IC50 of 47 nM. Synonyms: (S)-N-methyl-N-(((R)-5-((4-methylpiperazin-1-yl)amino)-1,2,3,4-tetrahydroisoquinolin-3-yl)methyl)-5,6,7,8-tetrahydroquinolin-8-amine. CAS No. 2243636-57-7. Molecular formula: C25H36N6. Mole weight: 420.59. | |
| CXCR4 Antagonist I, AMD3100 - CAS 155148-31-5 | The CXCR4 Antagonist I, AMD3100, also referenced under CAS 155148-31-5, controls the biological activity of CXCR4. This small molecule/inhibitor is primarily used for Cell Signaling applications. Group: Fluorescence/luminescence spectroscopy. |  |
| CXCR4 Antagonist II - CAS 1258011-83-4 | The CXCR4 Antagonist II, also referenced under CAS 1258011-83-4, controls the biological activity of CXCR4. This small molecule/inhibitor is primarily used for Cell Signaling applications. Group: Fluorescence/luminescence spectroscopy. | |
| CXCR4 Antagonist III | The CXCR4 Antagonist III controls the biological activity of CXCR4. This small molecule/inhibitor is primarily used for Biochemicals applications. Group: Fluorescence/luminescence spectroscopy. | |
| CXCR4 Antagonist III (Fusin Antagonist III, N2- (4- ( (3- (Cyclohexylamino) propylamino) methyl) benzyl) -N4- (piperidin-4-yl) quinazoline-2,4-diamine, 2HCl) | A cell-permeable quinazoline compound that acts as a potent and reversible CXCR4 antagonist (IC50=36.2nM for SDF-1/CXCL12 binding to hCXCR4-transfected HEK293 membrane) with selectivity over closely related human chemokine receptors CXCR2, CCR2, CCR4 and CCR5 (IC50 >10uM). Shown to inhibit CXCL12-induced Ca2+-mobilization and cell migration in hCXCR4-HEK293 cells (IC50=100.1 and 41nM, respectively), and rapidly mobilize CXCR4+, CD34+ and CD133+ stem cells from bone marrow in C57BL/6 male mice (6mg/kg, s.c). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| CXCR4 Antagonist IV, TF14016 (Fusin Antagonist IV) | A 14-aa internally disulfide-bonded peptide that potently competes against SDF-1alpha/CXCL12 for CXCR4 binding (IC50 = 0.91nM; [SDF-1] = 100nM) and protects MT-4 cells against X4-HIV strain HIV-1IIIB infection (EC50 = 4nM in 5 d; MOI = 0.01) with no significant cytotoxicity (CC50 = 56uM; 5 d). Inhibits SDF-1-induced Ca2+ mobilization (IC50 = 4.5nM; [SDF-1] = 30nM; CXCR4-expressing CHO cells) in vitro and effectively prevents CXCR4-dependent 5BC-5 metastasis in NK-depleted SCID mice in vivo (10mg/kg i.p.) in vivo. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2mg. Molecular Formula: C???H???FN??O??S?. xH?O, Sequence: N alpha-4-fluorobenzoyl-Arg-Arg-Nal-Cys4-Tyr-Cit-Lys-D-Lys-Pro-Tyr-Arg-Cit-Cys¹3-Arg-NH2 (Disulfide bond: 4 ? 13; Nal = L-3-(2-naphthyl)alanine; Cit = L-citrulline). US Biological Life Sciences. | Worldwide |
| 1,4,8,11-tetra(trifluoroacetyl)-1,4,8,11-tetraazacyclotetradecane | An impurity of Plerixafor which is an antagonist of the CXCR4 chemokine receptor. Synonyms: Plerixafor Impurity 26. CAS No. 201610-16-4. Molecular formula: C18H20F12N4O4. Mole weight: 584.36. | |
| 1,4,8-tritosyl-1,4,8,11-tetraazacyclotetradecane | An impurity of Plerixafor which is an antagonist of the CXCR4 chemokine receptor. Synonyms: 4,8,11-Tris(p-tolylsulfonyl)-1,4,8,11-tetraazacyclotetradecane; Plerixafor Impurity 35. Grade: 98%. CAS No. 104395-69-9. Molecular formula: C31H42N4O6S3. Mole weight: 662.88. | |
| 1,4-ditosyl-1,4,8,11-tetraazacyclotetradecane | An impurity of Plerixafor which is an antagonist of the CXCR4 chemokine receptor. Synonyms: Tetraazacyclotetradecane, 1,4-ditosyl-1,4,8,11-; Plerixafor Impurity 09. CAS No. 123530-19-8. Molecular formula: C24H36N4O4S2. Mole weight: 508.70. | |
| 1,8-dibenzyl-1,4,8,11-tetraazacyclotetradecane tetrahydrochloride | An impurity of Plerixafor which is an antagonist of the CXCR4 chemokine receptor. Synonyms: Plerixafor Impurity 30. Grade: >95%. CAS No. 267241-20-3. Molecular formula: C24H37ClN4. Mole weight: 417.04. | |
| 1-tosyl-1,4,8,11-tetraazacyclotetradecane trihydrochloride | An impurity of Plerixafor which is an antagonist of the CXCR4 chemokine receptor. Synonyms: Plerixafor Impurity 08. CAS No. 128495-30-7. Molecular formula: C17H31ClN4O2S. Mole weight: 390.97. | |
| Alverine Citrate | Alverine Citrate is a highly potent competitive CXCR4 antagonist with EC50 of 0.3 nM. Uses: Parasympatholytics. Synonyms: N-ethyl-3-phenyl-N-(3-phenylpropyl)propan-1-amine; 2-hydroxypropane-1,2,3-tricarboxylic acid. Grade: > 98 %. CAS No. 5560-59-8. Molecular formula: C20H27N · C6H8O7. Mole weight: 473.56. | |
| Alverine Citrate Impurity B | Alverine Citrate Impurity B is an impurity of Alverine Citrate, which is a highly potent competitive CXCR4 antagonist. It is a flavoring ingredient found in storax and fern balms, burdock fruits, guava fruit and peel, blackberries, rum, white wine, shiitake mushrooms, matsutake, and peat malt. Synonyms: Benzenepropanol; 1-Propanol, 3-phenyl-; (3-Hydroxypropyl)benzene; 1-Hydroxy-3-phenylpropane; 3-Benzenepropanol; 3-Hydroxy-1-phenylpropane; 3-Phenyl-1-propanol; 3-Phenyl-n-propanol; 3-Phenylpropanol; 3-Phenylpropyl alcohol; Dihydrocinnamic alcohol; Dihydrocinnamyl alcohol; Hydrocinnamic alcohol; Hydrocinnamyl alcohol; NSC 16942; γ-Phenylpropanol; γ-Phenylpropyl alcohol; Alverine EP Impurity B. Grade: ≥95%. CAS No. 122-97-4. Molecular formula: C9H12O. Mole weight: 136.19. | |
| ALX 40-4C | ALX 40-4C is a small peptide inhibitor of the chemokine receptor CXCR4, which inhibits the binding of SDF-1 to CXCR4 and inhibits the replication of X4 strain HIV-1. It is also an APJ receptor antagonist. Synonyms: Ac-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-NH2; N-acetyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-argininamide; Ac-(D-Arg)9-NH2; ALX40-4C; N-alpha-Acetyl-nona-D-arginine amide. Grade: ≥95%. CAS No. 143413-49-4. Molecular formula: C56H113N37O10. Mole weight: 1464.74. | |
| ALX 40-4C Trifluoroacetate | ALX 40-4C Trifluoroacetate is a small peptide inhibitor of the chemokine receptor CXCR4, which inhibits the binding of SDF-1 to CXCR4 and inhibits the replication of X4 strain HIV-1. It is also an APJ receptor antagonist. Synonyms: Ac-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-NH2.TFA; N-acetyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-argininamide trifluoroacetic acid; ALX 40-4C TFA. Grade: >98%. Molecular formula: C56H113N37O10.C2HF3O2. Mole weight: 1578.76. | |
| AMD-070 | AMD-070 is a potent and selective antagonist of CXCR4 (with an IC50 value of 13 nM in a CXCR4 125I-SDF inhibition binding assay). Synonyms: (S)-N1-((1H-benzo[d]imidazol-2-yl)methyl)-N1-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine; AMD11070; AMD-11070; AMD 11070; AMD-070; AMD 070; AMD070. Grade: ≥98% (HPLC). CAS No. 558447-26-0. Molecular formula: C21H27N5. Mole weight: 349.47. | |
| AMD 3100 octahydrochloride | AMD 3100 octahydrochloride is a high selective CXCR4 chemokine receptor antagonist (IC50 values are 0.02 - 0.13 and > 25 μM for CXCR4 and all other chemokine receptors respectively). Uses: Anti-hiv agents. Synonyms: Plerixafor Octahydrochloride; Bicyclam; 1-[[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,8,11-tetrazacyclotetradecane octahydrochloride. Grade: >98%. CAS No. 155148-31-5. Molecular formula: C28H54N8.8HCl. Mole weight: 794.48. | |
| AMD-3451 | AMD-3451 is a dual CCR5/CXCR4 antagonist. It is the first low-molecular-weight anti-HIV drug with selective interaction between HIV co-receptors CCR5 and CXCR4. Synonyms: 1,4,8,11-Tetraazacyclotetradecane, 1-((2,6-Dichloro-4-Pyridinyl)Methyl)-; 935VV663H3; AMD3451. CAS No. 255383-10-9. Molecular formula: C16H27Cl2N5. Mole weight: 360.3. | |
| AMD 3465 | AMD 3465,a N-pyridinylmethylene monocyclam, is a selective antagonist of CXCL12/CXCR4-mediated interactions including ligand binding and receptor activation. With its enhanced potency against the CXCR4 receptor compared with plerixafor, AMD 3465 has been. Synonyms: N-(pyridin-2-ylmethyl)-1-[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methanamine; hexahydrobromideAMD 3465 hexahydrobromide185991-07-5185991-24-6AMD3465 6 HBrC24H38N6.6BrHAMD3465; AMD 3465; AMD-3465GENZ-644494 N-(1,4,8,11- tetraazacyclotetradecanyl-1,4-phenylen. Grade: ≥98%. CAS No. 185991-24-6. Molecular formula: C24H38N6. Mole weight: 410.60. | |
| AMD 3465 hexahydrobromide | AMD 3465 hexahydrobromide (GENZ-644494 hexahydrobromide) is a potent antagonist of CXCR4 , inhibits binding of 12G5 mAb and CXCL12 AF647 to CXCR4 , with IC 50 s of 0.75 nM and 18 nM in SupT1 cells; AMD 3465 also potently inhibits the replication of X4 HIV strains ( IC 50 : 1-10 nM), but has no effect on CCR5-using (R5) viruses. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GENZ-644494 hexahydrobromide. CAS No. 185991-07-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15971. |  |
| AMD3465 hexahydrobromide | AMD 3465 is a potent and selective antagonist of CXCR4, inhibits binding of 12G5 mAb and CXCL12AF647 to CXCR4, with IC50s of 0.75 nM and 18 nM in SupT1 cells. AMD 3465 (50 nM) totally blocks CXCL12-induced calcium mobilization, with an IC50 of 17 nM, but shows no effect on the intracellular calcium fluxes elicited by the CCR5 ligands RANTES, LD78β and MIP-1β in U87.CD4.CCR5 cells. MD3465 was even 10-fold more effective as a CXCR4 antagonist, while showing no interaction whatsoever with CCR5. AMD3465 has the potential to mobilize hematopoietic stem cells. Synonyms: AMD3465; GENZ-644494 hexahydrobromide. Grade: ≥95%. CAS No. 185991-07-5. Molecular formula: C24H38N6·6HBr. Mole weight: 896.07. | |
| Balixafortide | Balixafortide is a potent and selective antagonist of the chemokine receptor CXCR4. The combination of balixafortide and eribulin was previously granted a fast track designation for the treatment of HER2-negative metastatic breast cancer in patients who have received at least 2 prior lines of chemotherapy in the metastatic setting by the FDA in 2018. Synonyms: POL6326. Grade: >98%. CAS No. 1051366-32-5. Molecular formula: C84H118N24O21S2. Mole weight: 1864.11. | |
| Burixafor hydrobromide | Burixafor hydrobromide is an orally bioavailable and potent CXCR4 antagonist, which is a good antiangiogenic drug and has potential value in the treatment of choroidal neovascularization. Synonyms: TG-0054 hydrobromide; (2-{4-[6-Amino-2-({[4-({[3-(cyclohexylamino)propyl]amino}methyl)cyclohexyl]methyl}amino)-4-pyrimidinyl]-1-piperazinyl}ethyl)phosphonic acid hydrobromide (1:1); Phosphonic acid, [2-[4-[6-amino-2-[[[4-[[[3-(cyclohexylamino)propyl]amino]methyl]cyclohexyl]methyl]amino]-4-pyrimidinyl]-1-piperazinyl]ethyl]-, hydrobromide (1:1). Grade: ≥95%. CAS No. 1191450-19-7. Molecular formula: C27H52BrN8O3P. Mole weight: 647.63. | |
| BX471 | BX471 (ZK-811752) is an orally active, potent and selective non-peptide CCR1 antagonist with a Ki of 1 nM, and exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ZK-811752. CAS No. 217645-70-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-12080. | |
| BX-471 | BX-471, also known as ZK-811752, is a potent, selective non-peptide CCR1 antagonist (Ki = 1 nM for human CCR1). BX-471 exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4. BX-471 was developed Berlex and its parent company, Schering AG. BX-471 is the lead in a series of non-peptide chemokine receptor 1 (CCR1) antagonists, for the potential treatment of autoimmune diseases, in particular multiple sclerosis (MS). In March 2000, BX-471 was undergoing phase I trials for the potential treatment of autoimmune diseases. Uses: Designed for use in research and industrial production. Additional or Alternative Names: BX471; BX 471; BX-471; ZK811752; ZK 811752; ZK-811752. Product Category: Antagonists. Appearance: Solid powder. CAS No. 217645-70-0. Molecular formula: C21H24ClFN4O3. Mole weight: 434.89. Purity: >98%. IUPACName: (R)-1-(5-chloro-2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)phenyl)urea. Canonical SMILES: C[C@H]1N(C(COC2=CC=C(Cl)C=C2NC(N)=O)=O)CCN(CC3=CC=C(F)C=C3)C1. Product ID: ACM217645700. Alfa Chemistry ISO 9001:2015 Certified. Categories: Bx41 (New York City bus). |  |
| BX-513 hydrochloride | BX 513 hydrochloride is a selective CCR1 receptor antagonist (Ki = 0.04, > 10, > 10 and > 10 nM for CCR1, CCR5, CXCR2 and CXCR4 receptors, respectively), and also acts as a US28 agonist. It inhibits MIP-1α-induced intracellular calcium mobilization (IC50 = 2.5 μM). Synonyms: BX 513 hydrochloride; 193542-65-3; 1216540-18-9; BX-513 HCl; BX513Hydrochloride; VUF 2274; BX-513; 5-[4-(4-CHLOROPHENYL)-4-HYDROXYPIPERIDIN-1-YL]-2,2-DIPHENYLPENTANENITRILE HYDROCHLORIDE; 5-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-2,2-diphenylpentanenitrile; hydrochloride; BX-513 hydrochloride; 4-(4-CHLOROPHENYL)-4-HYDROXY-A,A-DIPHENYL-1-PIPERIDINEPENTANENITRILE HYDROCHLORIDE; BX 513 HCL; DTXSID30719335; BCP27909; AKOS024457285; AS-57268; VUF 2274; VUF2274; BX513 hydrochloride; BX-513 hydrochloride; 1-Piperidinepentanenitrile,4-(4-chlorophenyl)-4-hydroxy-a,a-diphenyl-,HCl; 5-[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]-2,2-diphenylpentanenitrile--hydrogen chloride (1/1). Grade: ≥99% by HPLC. CAS No. 1216540-18-9. Molecular formula: C28H30Cl2N2O. Mole weight: 481.46. | |
| CTCE 9908 | It is a CXCR4 antagonist that induces mitotic catastrophe in ovarian cancer cells. Synonyms: L-Lysinamide, N2,N6-bis(L-lysylglycyl-L-valyl-L-seryl-L-leucyl-L-seryl-L-tyrosyl-L-arginyl)-; CTCE-9908; CTCE9908; H-Lys-Gly-Val-Ser-Leu-Ser-Tyr-Arg-Lys(1)-NH2.H-Lys-Gly-Val-Ser-Leu-Ser-Tyr-Arg-(1). Grade: >98%. CAS No. 1030384-98-5. Molecular formula: C86H147N27O23. Mole weight: 1927.27. | |
| CTCE-9908 | CTCE-9908 is a potent and selective CXCR4 antagonist. CTCE-9908 induces mitotic catastrophe, cytotoxicity and inhibits migration in CXCR4-expressing ovarian cancer cells [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 1030384-98-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P1103. | |
| Cyclo [3-? (2-? naphthalenyl) ? -? L-? alanylglycyl-? D-? tyrosyl-? L-? arginyl-? L-? arginyl] | Cyclo [3-? (2-? naphthalenyl) ? -? L-? alanylglycyl-? D-? tyrosyl-? L-? arginyl-? L-? arginyl] is a CXCR4 antagonist with anti-HIV properties. Group: Biochemicals. Grades: Highly Purified. CAS No. 606968-52-9. Pack Sizes: 1mg, 5mg. Molecular Formula: C36H47N11O6, Molecular Weight: 729.83. US Biological Life Sciences. | Worldwide |
| Diisopropyl sulfate | An impurity of Plerixafor which is an antagonist of the CXCR4 chemokine receptor. Synonyms: Sulfuric acid, bis(1-methylethyl) ester; Isopropyl sulfate; Di-isopropylsulphate; Plerixafor Impurity 38. Grade: 95%. CAS No. 2973-10-6. Molecular formula: C6H14O4S. Mole weight: 182.24. | |
| Di-tert-butyl 1,4,8,11-tetraazacyclotetradecane-1,11-dicarboxylate | An impurity of Plerixafor which is an antagonist of the CXCR4 chemokine receptor. Synonyms: 1,4,8,11-Tetraazacyclotetradecane-1,11-dicarboxylic acid, 1,11-bis(1,1-dimethylethyl) ester; Plerixafor Impurity 27. CAS No. 170161-28-1. Molecular formula: C20H40N4O4. Mole weight: 400.56. | |
| EPI-X4 | EPI-X4 (hSA408 - 423 peptide) is an antagonist for C-X-C motif chemokine receptor 4 ( CXCR4 ) with IC 50 of 8.6 μM. EPI-X4 blocks the CXCL12-mediated signaling, inhibits chemokine-mediated migration and invasion of leukemia cell. EPI-X4 exhibits anti-inflammatory activity in mouse model. EPI-X4 exhibits antiviral activity against CXCR4-tropic HIV with IC 50 of 8.6 μM [1]. Uses: Scientific research. Group: Peptides. Alternative Names: hSA(408 - 423) peptide. CAS No. 930280-31-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P10415. | |
| FC131 | FC 131 is a CXCR4 antagonist with anti-HIV activity. Synonyms: FC 131; FC-131; FC131; d-Tyr-Arg-Arg-2-Nal-Gly; Cyclo[2-Nal-Gly-D-Tyr-Arg-Arg]. Grade: ≥95%. CAS No. 606968-52-9. Molecular formula: C36H47N11O6. Mole weight: 729.84. | |
| FC131 TFA | FC131 TFA is a CXCR4 antagonist, inhibits [ 125 I]-SDF-1 binding to CXCR4, with an IC 50 of 4.5 nM. Anti- HIV activity [1]. Uses: Scientific research. Group: Peptides. CAS No. 842166-42-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1104A. | |
| FC131 TFA | FC131 TFA is a CXCR4 antagonist with anti-HIV activity. Synonyms: FC 131 TFA; FC-131 TFA. Molecular formula: C38H48F3N11O8. Mole weight: 843.85. | |
| IT1t dihydrochloride | IT1t dihydrochloride is a potent CXCR4 antagonist; inhibits CXCL12/CXCR4 interaction with an IC 50 of 2.1 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1092776-63-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101458A. | |
| LY2510924 | LY2510924 is a potent and selective CXCR4 antagonist that blocks SDF-1 binding to CXCR4 with an IC50 of 0.079 nM. Uses: Scientific research. Group: Peptides. CAS No. 1088715-84-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-12488. | |
| LY2510924 acetate | Ly2510924 acetate is a potent and selective CXCR4 antagonist that prevents the binding of SDF-1 to CXCR4 with an IC50 of 0.079 nM. It has potential antineoplastic activity. Synonyms: L-Lysinamide, L-phenylalanyl-L-tyrosyl-N6-(1-methylethyl)-L-lysyl-D-arginyl-3-(2-naphthalenyl)-L-alanylglycyl-D-α-glutamyl-N6-(1-methylethyl)-, (7→1)-lactam, acetate (1:1); LY 2510924 acetate; LY-2510924 acetate; N(1)Phe-Tyr-Lys(iPr)-D-Arg-2Nal-Gly-D-Glu(1)-Lys(iPr)-NH2 acetate. Grade: ≥95%. Molecular formula: C62H88N14O10.C2H4O2. Mole weight: 1249.53. | |
| Mavorixafor free base | Mavorixafor, also known as AMD11070, AMD070, X4P-001, is an orally bioavailable and potent CXCR4 inhibitor. AMD11070 is an antagonist of SDF-1α ligand binding (IC50 = 12.5 ± 1.3 nM), inhibits SDF-1 mediated calcium flux (IC50 = 9.0 ± 2.0 nM) and SDF-1α mediated activation of the CXCR4 receptor as measured by a Eu-GTP binding assay (IC50 =39.8 ± 2.5 nM) or a [(35)S]-GTPγS binding assay (IC50 =19.0 ± 4.1 nM), and inhibits SDF-1α stimulated chemotaxis (IC50 =19.0 ± 4.0 nM). AMD11070 abrogates melanoma cell migration and is significantly more effective than AMD3100. AMD11070 represents a novel therapeutic strategy for both B-RAF wild-type and mutated melanomas. Uses: Designed for use in research and industrial production. Additional or Alternative Names: AMD11070, AMD 11070, AMD-11070, AMD070, AMD 070, AMD-070, X4P-001, X49001, X4P 001, Mavorixafor. Product Category: Antagonists. Appearance: Solid powder. CAS No. 558447-26-0. Molecular formula: C21H27N5. Mole weight: 349.48. Purity: >95%. IUPACName: (S)-N1-((1H-benzo[d]imidazol-2-yl)methyl)-N1-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine. Canonical SMILES: NCCCCN([C@@H]1C2=NC=CC=C2CCC1)CC3=NC4=C(N3)C=CC=C4. Product ID: ACM558447260. Alfa Chemistry ISO 9001:2015 Certified. | |
| Mavorixafor hydrochloride | Mavorixafor (AMD-070) hydrochloride is a potent, selective and orally available CXCR4 antagonist, with an IC 50 value of 13 nM against CXCR4 125 I-SDF binding. Mavorixafor hydrochloride also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs with an IC 50 of 1 nM and 9 nM, respectively. Mavorixafor hydrochloride can be used for the study of WHIM syndrome [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AMD-070 hydrochloride; AMD-11070 hydrochloride. CAS No. 880549-30-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-50101C. | |
| Mavorixafor trihydrochloride | Mavorixafor trihydrochloride (AMD-070 trihydrochloride) is a potent, selective and orally available CXCR4 antagonist, with an IC50 value of 13 nM against CXCR4 125I-SDF binding, and also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs with an IC50 of 1 and 9 nM, respectively.Mavorixafor trihydrochloride can be used for the study of WHIM syndrome[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AMD-070 trihydrochloride; AMD-11070 trihydrochloride. CAS No. 2309699-17-8. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-50101A. | |
| ML339 | ML339 is a selective CXCR6 antagonist with an IC50 of 140 nM. ML339 antagonizes ?-arrestin recruitment and cAMP signaling pathway of human CXCR6 receptor induced by CXCL16, with IC50 of 0.3 ?M and 1.4 ?M, respectively. ML339 shows weaker activity against the recruitment of ?-arrestin in mouse CXCR6 receptors, with an IC50 of 18 ?M. ML339 has no inhibitory effect on CXCR5?CXCR4?CXCR6 and apelin receptor (APJ), with IC50 >79 ?M. ML339 has the potential to promote the development of prostate cancer research[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2579689-83-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122197. | |
| Motixafortide | Motixafortide (BKT140 4-fluorobenzoyl) is a novel CXCR4 antagonist with an IC 50 vakue of ~1 nM. Uses: Scientific research. Group: Peptides. Alternative Names: BKT140 (4-fluorobenzoyl); BL-8040; TF14016. CAS No. 664334-36-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P0171. | |
| NF279 | NF279 is a potent selective and reversible P2X1 receptor antagonist, with an IC 50 of 19 nM. NF279 displays good selectivity over P2X2, P2X3 (IC 50=1.62 μM), P2X4 (IC 50 >300 μM). NF279 is a dual HIV-1 coreceptor inhibitor that interferes with the functional engagement of CCR5 and CXCR4 by Env [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 202983-32-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-D0976. | |
| Plerixafor | Plerixafor (AMD 3100) is a selective CXCR4 antagonist with an IC 50 of 44 nM. Plerixafor, an immunostimulant and a hematopoietic stem cell (HSC) mobilizer, is an allosteric agonist of CXCR7. Plerixafor inhibits HIV-1 and HIV-2 replication with an EC 50 of 1-10 nM [1] [2] [3] [4] [7]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AMD 3100; JM3100; SID791. CAS No. 110078-46-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10046. | |
| Plerixafor-[d4] | Plerixafor-[d4] is the labelled analogue of Plerixafor, which is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5. 7 nM, respectively. Synonyms: Plerixafor D4; 1,1'-[(2H4)-1,4-Phenylenebis(methylene)]bis(1,4,8,11-tetraazacyclotetradecane). Grade: 95% by HPLC; 95% atom D. CAS No. 1246819-87-3. Molecular formula: C28H50D4N8. Mole weight: 506.81. | |
| Plerixafor octahydrochloride | Plerixafor octahydrochloride (AMD3100 octahydrochloride) is a selective CXCR4 antagonist with an IC50 of 44 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AMD3100 octahydrochloride; JM3100 octahydrochloride; SID791 octahydrochloride. CAS No. 155148-31-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-50912. | |
| TC14012 | TC 14012 is an antagonist of CXCR4. Synonyms: TC 14012; 368874-34-4; TC 14012 (trifluoroacetate salt); TC14012; H-Arg-Arg-2Nal-Cys(1)-Tyr-Cit-Lys-D-Cit-Pro-Tyr-Arg-Cit-Cys(1)-Arg-NH2; DA-67984; G14057; H-Arg-Arg-Nal-Cys-Tyr-Cit-Lys-DCit-Pro-Tyr-Arg-Cit-Cys-Arg-NH2. Grade: >95%. CAS No. 368874-34-4. Molecular formula: C18H28O5. Mole weight: 324.4. | |
| USL311 | USL311 is a CXCR4 receptor antagonist which prevents the binding of stromal-cell derived factor-1 (SDF-1 or CXCL12) to CXCR4. USL311 inhibits CXCR4 activation and decreases proliferation and migration of CXCR4-expressing tumor cells. Uses: Designed for use in research and industrial production. Additional or Alternative Names: USL-311; USL 311; USL311. Product Category: Antagonists. Appearance: Solid powder. CAS No. 1373268-67-7. Molecular formula: C24H34N6O. Mole weight: 422.58. Purity: >98%. IUPACName: 6-[4-(1-Propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]-N-pyridin-4-ylpyridine-2-carboxamide. Canonical SMILES: O=C(C1=NC(N2CCN(C3CCN(C(C)C)CC3)CCC2)=CC=C1)NC4=CC=NC=C4. Product ID: ACM1373268677. Alfa Chemistry ISO 9001:2015 Certified. Categories: US 311. | |
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