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| Product | Description | |
|---|---|---|
| 2'-Cyanobiphenyl-3-carboxylic acid | 2'-Cyanobiphenyl-3-carboxylic acid. Group: Biochemicals. Grades: Highly Purified. CAS No. 893736-75-9. Pack Sizes: 100mg, 250mg. Molecular Formula: C14H9NO2, Molecular Weight: 223.23. US Biological Life Sciences. |  Worldwide |
| 3-(Benzyloxy)-2'-cyanobiphenyl | 3-(Benzyloxy)-2'-cyanobiphenyl. Group: Biochemicals. Grades: Highly Purified. CAS No. 893736-92-0. Pack Sizes: 100mg, 250mg. Molecular Formula: C20H15NO, Molecular Weight: 285.339999999999. US Biological Life Sciences. | Worldwide |
| 4-[ (6-Acryloyloxy) hexyloxy]-4'-cyanobiphenyl | 4-[ (6-Acryloyloxy) hexyloxy]-4'-cyanobiphenyl. Group: Liquid crystal (lc) building blocksliquid crystal (lc) materials monomers. CAS No. 89823-23-4. Product ID: 6-[4-(4-cyanophenyl)phenoxy]hexyl prop-2-enoate. Molecular formula: 349.4g/mol. Mole weight: C22H23NO3. C=CC (=O)OCCCCCCOC1=CC=C (C=C1)C2=CC=C (C=C2)C#N. InChI=1S/C22H23NO3/c1-2-22 (24)26-16-6-4-3-5-15-25-21-13-11-20 (12-14-21)19-9-7-18 (17-23)8-10-19/h2, 7-14H, 1, 3-6, 15-16H2. IGHSOWSFSFGPAZ-UHFFFAOYSA-N. |  |
| 4'-Bromo-4-cyanobiphenyl | 4'-Bromo-4-cyanobiphenyl. Group: Organic light-emitting diode (oled) materials. Alternative Names: 4'-Bromo-4-cyano-biphenyl; 4'-bromo-[1,1'-biphenyl]-4-carbonitrile; 4-(4'-Bromophenyl)benzonitrile; 4'-Bromo-4-biphenylcarbonitrile; 4'-Bromo-biphenyl-4-carbonitrile; 4'-Bromo-4-cyano-biphenyl. CAS No. 57774-35-3. Product ID: 4-(4-bromophenyl)benzonitrile. Molecular formula: 258.11. Mole weight: C13H8BrN. C1=CC(=CC=C1C#N)C2=CC=C(C=C2)Br. InChI=1S/C13H8BrN/c14-13-7-5-12 (6-8-13)11-3-1-10 (9-15)2-4-11/h1-8H. BHVHKOVPWZKVCC-UHFFFAOYSA-N. 95%+. | |
| 4'-Bromo-4-cyanobiphenyl | 4'-Bromo-4-cyanobiphenyl is a biologically active agent that serves as a crucial constituent in the synthesis of medicinal drugs utilized in the remedy of different ailments, including cancer, autoimmune disorders, and arthritis. Its versatile chemical properties allow for enhanced efficacy in drug development, making it a valuable pharmaceutical intermediate. Synonyms: 4'-bromo-[1,1'-Biphenyl]-4-carbonitrile. CAS No. 57774-35-3. Molecular formula: C13H8BrN. Mole weight: 258.11. |  |
| 4-Butoxy-4'-cyanobiphenyl | 4-Butoxy-4'-cyanobiphenyl. Group: Liquid crystal (lc) materials. Alternative Names: 4'-Butyloxy-4-biphenylcarbonitrile 4OCB. CAS No. 52709-87-2. Product ID: 4-(4-butoxyphenyl)benzonitrile. Molecular formula: 251.33. Mole weight: C17H17NO. CCCCOC1=CC=C(C=C1)C2=CC=C(C=C2)C#N. InChI=1S / C17H17NO / c1-2-3-12-19-17-10-8-16 (9-11-17) 15-6-4-14 (13-18) 5-7-15 / h4-11H, 2-3, 12H2, 1H3. KPQVQWUNELODQE-UHFFFAOYSA-N. >98.0%(GC). | |
| 4-Butyl-4'-cyanobiphenyl | 4-Butyl-4'-cyanobiphenyl. Group: Liquid crystal (lc) materials. Alternative Names: 4'-Butyl-4-biphenylcarbonitrile 4CB. CAS No. 52709-83-8. Product ID: 4-(4-butylphenyl)benzonitrile. Molecular formula: 235.33. Mole weight: C17H17N. CCCCC1=CC=C(C=C1)C2=CC=C(C=C2)C#N. InChI=1S/C17H17N/c1-2-3-4-14-5-9-16 (10-6-14)17-11-7-15 (13-18)8-12-17/h5-12H, 2-4H2, 1H3. PJPLBHHDTUICNN-UHFFFAOYSA-N. >98.0%(GC). | |
| 4-Cyanobiphenyl | 4-Cyanobiphenyl. Group: Liquid crystal (lc) building blocks other electronic materials. Alternative Names: P-PHENYLBENZONITRILE; 4-Biphenylcarboxylic acid nitrile; 4-Cyanobiphenly; p-Cyanobiphenyl; 4-BIPHENYLCARBONITRILE; 4-DIPHENYLCARBONITRILE; 4-CYANODIPHENYL; 4-CYANOBIPHENYL. CAS No. 2920-38-9. Product ID: 4-phenylbenzonitrile. Molecular formula: 179.22. Mole weight: C13H9N. C1=CC=C(C=C1)C2=CC=C(C=C2)C#N. BPMBNLJJRKCCRT-UHFFFAOYSA-N. 95+%. | |
| 4-Cyanobiphenyl (4-biphenylcarbonitrile) | 4-Cyanobiphenyl (4-biphenylcarbonitrile). Group: Biochemicals. Alternative Names: 4-Biphenylcarbonitrile. Grades: Highly Purified. CAS No. 2920-38-9. Pack Sizes: 50g, 100g, 250g, 500g, 1kg. Molecular Formula: C13H9N. US Biological Life Sciences. | Worldwide |
| 6-(4'-Cyanobiphenyl-4-yloxy)hexyl acrylate | Colorless powder, 98%. CAS No. 89823-23-4. Pack Sizes: 5g, 25g. Product ID: FR-2708. M.P. 70-71. Mole weight: 349.43. |  Frinton Laboratories |
| 1- [ (2'-Cyano-1, 1'-biphenyl -4-yl ) methyl ] -2-ethoxy-7-benzimidazolecarboxyl ic Acid Methyl Ester | Intermediate in the synthesis of angiotensin II receptor antagonist. Group: Biochemicals. Alternative Names: 3-[(2'-Cyanobiphenyl-4-yl)methyl]-2-ethoxy-3H-benzimidazole-4-carboxylic Acid Methyl Ester; Methyl 1-[(2'-Cyanobiphenyl-4-yl)methyl]-2-ethoxybenzimidazole-7-carboxylate. Grades: Highly Purified. CAS No. 139481-44-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 1- [ (2'-Cyano-1, 1'-biphenyl -4-yl ) methyl ] -2-ethoxy-d5-7-benzimidazolecarboxyl ic Acid Methyl Ester | Intermediate in the synthesis of angiotensin II receptor antagonist. Group: Biochemicals. Alternative Names: 3-[(2'-Cyanobiphenyl-4-yl)methyl]-2-ethoxy-d5-3H-benzimidazole-4-carboxylic Acid Methyl Ester; Methyl 1-[(2'-Cyanobiphenyl-4-yl)methyl]-2-ethoxybenzimidazole-7-carboxylate-d5. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| 2-[[ (2'-Cyano[1, 1'-biphenyl]-4-yl) methyl][ (1, 1-dimethylethoxy) carbonyl]amino]-3-nitrobenzoic Acid Methyl Ester | Intermediate in the synthesis of nonpeptide angiotensin II receptor antagonists. Group: Biochemicals. Alternative Names: Methyl 2-[N-(tert-Butoxycarbonyl)-N-[(2'-cyanobiphenyl-4-yl)methyl]amino]-3-nitrobenzoate. Grades: Highly Purified. CAS No. 139481-38-2. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| 2-[[(2'-Cyano[1,1'-biphenyl]-4-yl)methyl]amino]-3-nitro-benzoic Acid Methyl Ester | Intermediate in the synthesis of nonpeptide angiotensin II receptor antagonists. Group: Biochemicals. Alternative Names: Methyl 2-[[(2'-Cyanobiphenyl-4-yl)methyl]amino]-3-nitrobenzoate. Grades: Highly Purified. CAS No. 139481-28-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 2-[4- (Hydroxymethyl) phenyl]benzonitrile | 2-[4- (Hydroxymethyl) phenyl]benzonitrile is an impurity of 4-Bromomethyl-2-cyanobiphenyl (B685335), which is used in protein-binding studies of quinoxaline angiotensin II receptor antagonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 154709-19-0. Pack Sizes: 100mg, 250mg. Molecular Formula: C14H11NO, Molecular Weight: 209.24. US Biological Life Sciences. | Worldwide |
| 2-[4- (Hydroxymethyl) phenyl]benzonitrile-d4 | 2-[4- (Hydroxymethyl) phenyl]benzonitrile-d4 is the isotope labelled analog of 2-[4- (Hydroxymethyl) phenyl]benzonitrile. 2-[4- (Hydroxymethyl) phenyl]benzonitrile is an impurity of 4-Bromomethyl-2-cyanobiphenyl (B685335), which is used in protein-binding studies of quinoxaline angiotensin II receptor antagonists. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C14H7D4NO, Molecular Weight: 213.27. US Biological Life Sciences. | Worldwide |
| 2'-Cyano-4-bromomethylbiphenyl | 2'-Cyano-4-bromomethylbiphenyl. Group: Liquid crystal (lc) materials. Alternative Names: 4-BROMOMETHYLBIPHENYL-2-CARBONITRILE; 4-BROMOMETHYL-2-BIPHENYLCARBONITRILE; 4-BROMOMETHYL-2-CYANOBIPHENYL; [1,1-BIPHENYL]-2-CARBONITRILE, 4-(BROMOMETHYL)-; 2-CYANO-4-BROMOMETHYL BIPHENYL; 2-CYANO-4-BROMOMETHYLBIPHENYL; 2-(4-BROMO-METHYLPHENYL) BENZONITRILE; OTBN. CAS No. 114772-54-2. Product ID: 2-[4- (bromomethyl)phenyl]benzonitrile. Molecular formula: 272.14. Mole weight: C14H10BrN. C1=CC=C(C(=C1)C#N)C2=CC=C(C=C2)CBr. LFFIEVAMVPCZNA-UHFFFAOYSA-N. 98%. | |
| 2'-Cyano-4-bromomethylbiphenyl | Bromine Series. Alternative Names: 4-BROMOMETHYLBIPHENYL-2-CARBONITRILE;4-BROMOMETHYL-2-BIPHENYLCARBONITRILE;4-BROMOMETHYL-2-CYANOBIPHENYL;[1,1-BIPHENYL]-2-CARBONITRILE, 4-(BROMOMETHYL)-;2-CYANO-4-BROMOMETHYL BIPHENYL;2-CYANO-4-BROMOMETHYLBIPHENYL;2-(4-BROMO-METHYLPHENYL) BENZONITRILE;OTBN. CAS No. 114772-54-2. Molecular formula: C14H10BrN. Mole weight: 272.14. Appearance: Cream powder. Purity: 0.98. IUPACName: 2-[4- (bromomethyl)phenyl]benzonitrile. Canonical SMILES: C1=CC=C(C(=C1)C#N)C2=CC=C(C=C2)CBr. Density: 1.43g/cm³. ECNumber: 601-327-7. Catalog: ACM114772542. |  |
| 2-Cyano-4'-methylbiphenyl | 2-Cyano-4'-methylbiphenyl. Group: Liquid crystal (lc) materials. Alternative Names: AKOS BAR-1203; 4-METHYLBIPHENYL-2-CARBONITRILE; 4-METHYL-2-BIPHENYLCARBONITRILE; 4-METHYL-2-CYANOBIPHENYL; 4-METHYL[1,1-BIPHENYL]-2-CARBONITRILE; 2-(4-TOLYL)-BENZONITRILE; 2-(4-METHYLPHENYL)BENZONITRILE; [2-(P-TOLYL)BENZONITRILE]. CAS No. 114772-53-1. Product ID: 2-(4-methylphenyl)benzonitrile. Molecular formula: 193.24g/mol. Mole weight: C14H11N. CC1=CC=C(C=C1)C2=CC=CC=C2C#N. InChI=1S/C14H11N/c1-11-6-8-12 (9-7-11)14-5-3-2-4-13 (14)10-15/h2-9H, 1H3. ZGQVZLSNEBEHFN-UHFFFAOYSA-N. | |
| 2-Cyano-4'-methylbiphenyl | Other. Alternative Names: AKOS BAR-1203;4-METHYLBIPHENYL-2-CARBONITRILE;4-METHYL-2-BIPHENYLCARBONITRILE;4-METHYL-2-CYANOBIPHENYL;4-METHYL[1,1-BIPHENYL]-2-CARBONITRILE;2-(4-TOLYL)-BENZONITRILE;2-(4-METHYLPHENYL)BENZONITRILE;[2-(P-TOLYL)BENZONITRILE]. CAS No. 114772-53-1. Molecular formula: C14H11N. Mole weight: 193.24g/mol. IUPACName: 2-(4-methylphenyl)benzonitrile. Canonical SMILES: CC1=CC=C(C=C1)C2=CC=CC=C2C#N. ECNumber: 422-310-9;601-326-1. Catalog: ACM114772531. | |
| 4[4[6-Acryloxyhex-1-yl)-oxyphenyl]carboxy-biphenyl-4'-carbonitrile | Other Crystal Monomers. Alternative Names: 4'-Cyanobiphenyl-4-yl4-{[6- (acryloyloxy)hexyl]oxy}benzoate. CAS No. 130166-92-6. Molecular formula: C29H27NO5. Mole weight: 469.53. Purity: 98%+. IUPACName: [4-(4-cyanophenyl)phenyl] 4-(6-prop-2-enoyloxyhexoxy)benzoate. Canonical SMILES: C=CC (=O)OCCCCCCOC1=CC=C (C=C1)C (=O)OC2=CC=C (C=C2)C3=CC=C (C=C3)C#N. Catalog: ACM130166926. | |
| 4'-(azidomethyl)-[1,1'-biphenyl]-2-carbonitrile | An impurity of Irbesartan, an angiotensin II receptor blocker used to treat hypertension and heart failure. Synonyms: Irbesartan Impurity 14; 4-Azidomethyl-2'-cyanobiphenyl. CAS No. 133690-91-2. Molecular formula: C14H10N4. Mole weight: 234.26. | |
| 4-Bromomethyl-2-cyanophenyl | Halogenated benzonitrile used in protein-binding studies of quinoxaline angiotensin II receptor antagonists. Group: Biochemicals. Alternative Names: 4'-(Bromomethyl)-[1,1'-biphenyl]-2-carbonitrile; 2- (4-Bromomethylphenyl) benzonitrile; 4-(2-Cyanophenyl)benzyl Bromide; 4'-(Bromomethyl)-2-cyanobiphenyl. Grades: Highly Purified. CAS No. 114772-54-2. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| 4-Cyano-4'-decyloxybiphenyl | 10OCB, crystalline, 99%. Synonyms: 4-Decyloxy-4'-cyanobiphenyl. CAS No. 70247-25-5. Pack Sizes: 2g, 10g. Product ID: FR-2528. M.P. 59 (SM-A), 84 (I). Mole weight: 335.49. | Frinton Laboratories |
| 4-Cyano-4'-hydroxybiphenyl | 4-Cyano-4'-hydroxybiphenyl. Group: Liquid crystal (lc) building blocks. Alternative Names: (HYDROXYPHENYL-4)-4 BENZONITRILE; 4-HYDROXYBIPHENYL-4-CARBONITRIL; 4-HYDROXYBIPHENYL-4-CARBONITRILE; 4-HYDROXY[1,1-BIPHENYL]-4-CARBONITRILE; 4-HYDROXY-4-BIPHENYLCARBONITRILE; 4-HYDROXY-4-CYANOBIPHENYL; 4-CYANO-4-HYDROXY-1,1-BIPHENYL; 4-CYANO-4-HYDROXYBIPHENYL. CAS No. 19812-93-2. Product ID: 4-(4-hydroxyphenyl)benzonitrile. Molecular formula: 195.22g/mol. Mole weight: C13H9NO. C1=CC(=CC=C1C#N)C2=CC=C(C=C2)O. InChI=1S/C13H9NO/c14-9-10-1-3-11 (4-2-10)12-5-7-13 (15)8-6-12/h1-8, 15H. ZRMIETZFPZGBEB-UHFFFAOYSA-N. | |
| 4-Cyano-4'-pentylbiphenyl | 4-Cyano-4'-pentylbiphenyl. Group: Liquid crystal (lc) building blocksliquid crystal (lc) materials. Alternative Names: 4'-Amyl-4-biphenylcarbonitrile 4-Amyl-4'-cyanobiphenyl 4'-Pentyl-4-biphenylcarbonitrile 5CB. CAS No. 40817-08-1. Product ID: 4-(4-pentylphenyl)benzonitrile. Molecular formula: 249.36. Mole weight: C18H19N. CCCCCC1=CC=C(C=C1)C2=CC=C(C=C2)C#N. InChI=1S / C18H19N / c1-2-3-4-5-15-6-10-17 (11-7-15) 18-12-8-16 (14-19) 9-13-18 / h6-13H, 2-5H2, 1H3. HHPCNRKYVYWYAU-UHFFFAOYSA-N. >98.0%(GC). | |
| 4-Cyano-4'-pentyloxybiphenyl | 4-Cyano-4'-pentyloxybiphenyl. Uses: 5-ocb may be used in indicators and storage devices. Group: Liquid crystal (lc) building blocksliquid crystal (lc) materials. Alternative Names: 4'-Amyloxy-4-biphenylcarbonitrile 4-Amyloxy-4'-cyanobiphenyl 4'-Pentyloxy-4-biphenylcarbonitrile 5OCB. CAS No. 52364-71-3. Product ID: 4-(4-pentoxyphenyl)benzonitrile. Molecular formula: 265.36. Mole weight: C18H19NO. CCCCCOC1=CC=C(C=C1)C2=CC=C(C=C2)C#N. InChI=1S / C18H19NO / c1-2-3-4-13-20-18-11-9-17 (10-12-18) 16-7-5-15 (14-19) 6-8-16 / h5-12H, 2-4, 13H2, 1H3. RDISTOCQRJJICR-UHFFFAOYSA-N. >98.0%(GC). | |
| 4'-Methylbiphenyl-2-carbonitrile | 4'-Methylbiphenyl-2-carbonitrile is an intermediate in the synthesis of glycogen synthase kinase-3 inhibitors with a selective sting for glycogen synthase kinase 3α. Group: Biochemicals. Alternative Names: 2- (4-Methylphenyl) benzonitrile; 2-(p-Tolyl)benzonitrile; 2-Cyano-4'-methyl-1,1'-biphenyl; 2-Cyano-4'-methylbiphenyl; 2'-Cyano-4-methylbiphenyl; 4-Methyl-2'-cyanobiphenyl; 4'-Methyl-2-cyanobiphenyl; 4'-Methyl[1,1'-biphenyl]-2-carbonitrile; 4'-Methyl-[1,1'-biphenyl]-2-carbonitrile. Grades: Highly Purified. CAS No. 114772-53-1. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
| 4-Propoxy-[1, 1'-biphenyl]-4'-carbonitrile | 4-Propoxy-[1, 1'-biphenyl]-4'-carbonitrile. Group: Liquid crystal (lc) materials. Alternative Names: 3OCB; 4'-PROPOXY-BIPHENYL-4-CARBONITRILE; 4-PROPOXY-4'-CYANOBIPHENYL; 4-CYANO-4'-PROPYLOXYBIPHENYL; AKOS BAR-2141; 1'-biphenyl)-4-carbonitrile,4'-propoxy-(; 1'-biphenyl]-4-carbonitrile,4'-propoxy-[; 1'-Biphenyl]-4-carbonitrile,4'-propoxy-[1. CAS No. 52709-86-1. Product ID: 4-(4-propoxyphenyl)benzonitrile. Molecular formula: 237.3g/mol. Mole weight: C16H15NO. CCCOC1=CC=C(C=C1)C2=CC=C(C=C2)C#N. InChI=1S / C16H15NO / c1-2-11-18-16-9-7-15 (8-10-16) 14-5-3-13 (12-17) 4-6-14 / h3-10H, 2, 11H2, 1H3. RZCQJZFWJZHMPK-UHFFFAOYSA-N. | |
| 4'-Undecyl[1,1'-biphenyl]-4-carbonitrile | 4'-Undecyl[1,1'-biphenyl]-4-carbonitrile. Group: Liquid crystal (lc) materials. Alternative Names: 4'-undecyl[1,1'-biphenyl]-4-carbonitrile; 4-Undecyl-4'-cyanobiphenyl; 4-CYANO-4''-UNDECYLBIPHENYL; 11CB; (1,1'-Biphenyl)-4-carbonitrile, 4'-undecyl-; Einecs 265-953-9. CAS No. 65860-74-4. Product ID: 4-(4-undecylphenyl)benzonitrile. Molecular formula: 333.5g/mol. Mole weight: C24H31N. CCCCCCCCCCCC1=CC=C (C=C1)C2=CC=C (C=C2)C#N. InChI=1S / C24H31N / c1-2-3-4-5-6-7-8-9-10-11-21-12-16-23 (17-13-21) 24-18-14-22 (20-25) 15-19-24 / h12-19H, 2-11H2, 1H3. YIJBPYUXIFSTAP-UHFFFAOYSA-N. | |
| Azilsartan Impurity I | Azilsartan Impurity I is an impurity found in azilsartan, a medication primarily used for the therapy of hypertension. Synonyms: Methyl 1-((2'-cyanobiphenyl-4-yl) Methyl)-2H-benziMidazol-2-one-7-carboxylate); Methyl 3-((2'-cyanobiphenyl-4-yl)Methyl)-2-oxo-2,3-dihydro-1H-benzo[d]iMidazole-4-carboxylate. Grades: > 95%. CAS No. 139481-33-7. Molecular formula: C23H17N3O3. Mole weight: 383.41. | |
| Azilsartan Impurity M | Azilsartan Impurity M is a superlative impurity of Azilsartan, an instrumental antihypertensive. Synonyms: 1-((2'-cyanobiphenyl-4-yl)Methyl)-2-ethoxy-1H-benziMidazole-7-carboxylic acid; 3-((2'-cyanobiphenyl-4-yl)Methyl)-2-ethoxy-3H-benzo[d]iMidazole-4-carboxylic acid; 1-((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylic acid. Grades: > 95%. CAS No. 632322-61-3. Molecular formula: C24H19N3O3. Mole weight: 397.44. | |
| Irbesartan impurity | An impurity of Irbesartan. Synonyms: N-((2'-cyanobiphenyl-4-yl)methyl)-1-pentanamido cyclopentane carboxamide. Grades: > 95%. CAS No. 141745-71-3. Molecular formula: C25H29N3O2. Mole weight: 403.53. | |
| Losartan Related Compound B | Des[2'-(1H-tetrazol-5-yl)] 2-Cyanolosartan is a derivative of Losartan Potassium, an angiotensin II antagonist and is commonly used to significantly reduce risk of new onset atrial fibrillation and associated stroke in high-risk patients. Synonyms: Des[2'-(1H-tetrazol-5-yl)] 2-Cyanolosartan; 4'-[[2-Butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl]-[1,1'-biphenyl]-2-carbonitrile; 2-Butyl-4-chloro-1-[(2'-cyanobiphenyl-4-yl)methyl]-5-hydroxymethylimidazole; 4'-(2-Butyl-4-chloro-5-hydroxymethyl-. Grades: > 95%. CAS No. 114772-55-3. Molecular formula: C22H22ClN3O. Mole weight: 379.88. | |
| PF 915275 | PF-915275 is a selective and potent and inhibitor of human 11β-hydroxysteroid dehydrogenase type 1(11βHSD1) inhibitor with Ki 2.3 nM. It has good preclinical pharmacokinetic properties. It inhibits the conversion of prednisone to prednisolone in human hepatocytes in vitro and has antidiabetic activity in vivo. It maintains potency in our cellular assay against human 11βHSD1 and is selective against human 11βHSD2 in vitro. It displays only weak affinity for the rodent choline transporter (Ki = 9.6 μM) and the hamster melatonin MT3 receptor (Ki = 9.6 μM) in the Cerep Bioprint screening panel. It has good in vitro pharmacokinetic properties. It has low clearance and high permeability. It has an excellent pharmacokinetic profile characterized by low clearance, long half-life and good oral bioavailability. Uses: Pf-915275 inhibits the conversion of prednisone to prednisolone in human hepatocytes in vitro and has antidiabetic activity in vivo. it has an excellent pharmacokinetic profile characterized by low clearance, long half-life and good oral bioavailability. Synonyms: PF-915275; PF 915275; PF915275; N-(6-Amino-2-pyridinyl)-4'-cyano-[1,1'-biphenyl]-4-sulfonamide;N-(6-aminopyridin-2-yl)-4-(4-cyanophenyl)benzenesulfonamide;[1,1'-Bip;4'-cyanobiphenyl-4-sulfonic acid (6-aminopyridin-2-yl)amide. Grades: >98 %. CAS No. 857290-04-1. Molecular formula: C18H14N4O2S. Mole weight: 350.39. | |
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