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(1R,2R)-rel-2-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]-N,N-diethyl-1-phenyl-cyclopropanecarboxamide is an intermediate in the synthesis of Milnacipran, which is a serotonin-norepinephrine reuptake inhibitor (SNRI) used in the clinical treatment of fibromyalgia. Synonyms: (1R,2R)-rel-2-(1,3-Dioxoisoindolin-2-yl)-N,N-diethyl-1-phenylcyclopropanecarboxamide; Cyclopropanecarboxamide, 2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]-N,N-diethyl-1-phenyl-, rel-(1R,2R)-. CAS No. 907205-34-9. Molecular formula: C23H24N2O3. Mole weight: 376.45.
(1R,2R)-rel-N,N-Diethyl-2-(hydroxymethyl)-1-phenyl-cyclopropanecarboxamide is an intermediate in the synthesis of Milnacipran, which is a serotonin-norepinephrine reuptake inhibitor (SNRI) used in the clinical treatment of fibromyalgia. Synonyms: Cyclopropanecarboxamide, N,N-diethyl-2-(hydroxymethyl)-1-phenyl-, (1R,2R)-rel-. CAS No. 1797131-72-6. Molecular formula: C15H21NO2. Mole weight: 247.33.
(1R,2S)-rel-N,N-Diethyl-2-[[[(4-methylphenyl)sulfonyl]oxy]methyl]-1-phenyl-cyclopropanecarboxamide is an intermediate in the synthesis of Milnacipran, which is a serotonin-norepinephrine reuptake inhibitor (SNRI) used in the clinical treatment of fibromyalgia. Synonyms: rel-((1R,2S)-2-(diethylcarbamoyl)-2-phenylcyclopropyl)methyl 4-methylbenzenesulfonate; Cyclopropanecarboxamide, N,N-diethyl-2-[[[(4-methylphenyl)sulfonyl]oxy]methyl]-1-phenyl-, (1R,2S)-rel-; rel-(1R,2S)-N,N-Diethyl-2-[[[(4-methylphenyl)sulfonyl]oxy]methyl]-1-phenylcyclopropanecarboxamide. CAS No. 923037-67-6. Molecular formula: C22H27NO4S. Mole weight: 401.52.
N,N-Diethyl-2-methylene-1-phenyl-cyclopropanecarboxamide is an impurity of Milnacipran, which is a serotonin-norepinephrine reuptake inhibitor (SNRI) used in the clinical treatment of fibromyalgia. Synonyms: Cyclopropanecarboxamide, N,N-diethyl-2-methylene-1-phenyl-. CAS No. 1418000-38-0. Molecular formula: C15H19NO. Mole weight: 229.32.
(1R-cis)-Milnacipran Hydrochloride
(1R-cis)-Milnacipran Hydrochloride is the (1R-cis)-enatiomer of Milnacipran, which is a serotonin-norepinephrine reuptake inhibitor (SNRI) used in the clinical treatment of fibromyalgia. Uses: Analgesics, non-narcotic. Synonyms: (1R,2S)-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide Hydrochloride; Levomilnacipran; Savella; cis-(-)-Milnacipran Hydrochloride; Cyclopropanecarboxamide, 2-(aminomethyl)-N,N-diethyl-1-phenyl-, hydrochloride (1:1), (1R,2S)-; Cyclopropanecarboxamide, 2-(aminomethyl)-N,N-diethyl-1-phenyl-, monohydrochloride, (1R,2S)-; Cyclopropanecarboxamide, 2-(aminomethyl)-N,N-diethyl-1-phenyl-, monohydrochloride, (1R-cis)-; (1R,2S)-Milnacipran hydrochloride; Dextromilnacipran hydrochloride; F 2696 hydrochloride. Grades: 95%. CAS No. 175131-61-0. Molecular formula: C15H23ClN2O. Mole weight: 282.81.
BMS-3, a LIMK1 inhibitor, could be probably influence the migration and cycle progression of cells so that has patential value in studying its effect against cancer. Synonyms: N-(5-(1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl)thiazol-2-yl)cyclopropanecarboxamide; BMS3; BMS 3; Cyclopropanecarboxamide, N-[5-[1-(2,6-dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]-2-thiazolyl]-; N-{5-[1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]-1,3-thiazol-2-yl}cyclopropanecarboxamide. Grades: 95%. CAS No. 1338247-30-5. Molecular formula: C17H12Cl2F2N4OS. Mole weight: 429.27.
A cell-permeable and highly selective EGFR tyrosine kinase inhibitor with IC50 value in the nanomolar range. Inhibition of EGFR induces apoptosis of tumor cells by ownregulating antiapoptotic proteins such as survivin and upregulating proapoptotic proteins such as Bim. Uses: Antitumor agent. Synonyms: EGFR inhibitor; EGFR-inhibitor; EGFRinhibitor; Cyclopropanecarboxylic acid-(3-(6-(3-trifluoromethyl-phenylamino)-pyrimidin-4-ylamino)-phenyl)-amide; N- (3- ( (6- ( (3- (Trifluoromethyl) phenyl) amino) pyrimidin-4-yl) amino) phenyl) cyclopropanecarboxamide; K00598a. Grades: 99%. CAS No. 879127-07-8. Molecular formula: C21H18F3N5O. Mole weight: 413.4.
Filgotinib
Filgotinib is a potent and selective JAK1 inhibitor exhibiting 30-fold selectivity over JAK2. It was shown to inhibit Th1 and Th2 differentiation and to a lesser extent the differentiation of Th17 cells in vitro. Filgotinib has the potential for the treatment of rheumatoid arthritis and possibly other immune-inflammatory diseases. Synonyms: GLPG0634; GLPG-0634; N-[5-[4-[(1,1-dioxo-1,4-thiazinan-4-yl)methyl]phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide. Grades: >98%. CAS No. 1206161-97-8. Molecular formula: C21H23N5O3S. Mole weight: 425.507.
GDC-0575, also known as ARRY-575 and RG7741, is a potent and selective inhibitor of cell cycle checkpoint kinase 1 (Chk1) with an IC50 of 1.2?nM. Chk1 inhibitor GDC-0575 specifically binds to and inhibits Chk1; this may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases, which permits the cells to undergo DNA repair prior to entry into mitosis. Group: Inhibitors. Alternative Names: GDC-0575; GDC 0575; GDC0575; ARRY-575; ARRY-575; ARRY575; RG7741; RG-7741; RG 7741; AK 687476; AK-687476; AK687476; GDC-0575 HCl; GDC-0575 hydrochloride. CAS No. 1196541-47-5. Molecular formula: C16H20BrN5O. Mole weight: 378.27. Appearance: Solid powder. Purity: >98%. IUPACName: (R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide. Canonical SMILES: O=C (C1CC1)NC2=CNC3=NC=C (Br)C (N4C[C@H] (N)CCC4)=C32. Catalog: ACM1196541475.
GLPG0634 analogue
A potent and selective JAK1 inhibitor with IC50 values of 10, 28, 810, and 116 nM for JAK1, JAK2, JAK3, and TYK2, respectively. Synonyms: GLPG0634 analog; N-[5-[4-[(6-cyanopyridin-3-yl)methoxy]phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide. Grades: >98%. CAS No. 1206101-20-3. Molecular formula: C23H18N6O2. Mole weight: 410.43.
KDM5A-IN-1
KDM5A-IN-1, a pyrrolidine amide compound, is an inhibitor histone demethylases. Synonyms: KDM5A-IN-1; KDM5A IN 1; KDM5AIN1; KDM5A inhibitor-1; KDM5A inhibitor 1; N-[(3R)-1-(5-propan-2-yl-1H-pyrazole-3-carbonyl)pyrrolidin-3-yl]cyclopropanecarboxamideKDM5A-IN-1. CAS No. 1905481-36-8. Molecular formula: C15H22N4O2. Mole weight: 290.36.
Milnacipran Impurity 1
rac 2-Desaminomethyl-2-chloromethyl Milnacipran is an impurity of Milnacipran. rac-Milnacipran Hydrochloride is an antidepressant. Synonyms: rac 2-Desaminomethyl-2-chloromethyl Milnacipran; 2-(Chloromethyl)-N,N-diethyl-1-phenyl-cyclopropanecarboxamide. Grades: > 95%. CAS No. 1353644-50-4. Molecular formula: C15H20ClNO. Mole weight: 265.78.
Grazoprevir is a hepatitis C virus protease inhibitor developed for the treatment of hepatitis C. It suppresses NS3 and NS4A, which play a role in the virus splitting its polyprotein into the functional virus proteins. Grazoprevir is often used in combination with elbasvir or ribavirin. Uses: Antiviral agents. Synonyms: Cyclopropanecarboxamide, N-[[[ (1R, 2R) -2-[5- (3-hydroxy-6-methoxy-2-quinoxalinyl) pentyl]cyclopropyl]oxy]carbonyl]-3-methyl-L-valyl- (4R) -4-hydroxy-L-prolyl-1-amino-N- (cyclopropylsulfonyl) -2-ethenyl-, cyclic (1?2)-ether, (1R,2S)-; Grazoprevir; (1R, 2S) -N-[[[ (1R, 2R) -2-[5- (3-Hydroxy-6-methoxy-2-quinoxalinyl) pentyl]cyclopropyl]oxy]carbonyl]-3-methyl-L-valyl- (4R) -4-hydroxy-L-prolyl-1-amino-N- (cyclopropylsulfonyl) -2-ethenylcyclopropanecarboxamide Cyclic (1?2)-Ether. Grades: >98%. CAS No. 1350514-68-9. Molecular formula: C38H50N6O9S. Mole weight: 766.91.
p-Hydroxy Levomilnacipran Hydrochloride
p-Hydroxy Levomilnacipran Hydrochloride is a derivative of Milnacipran, which is a serotonin-norepinephrine reuptake inhibitor (SNRI) used in the clinical treatment of fibromyalgia. Synonyms: (1R,2S)-2-(Aminomethyl)-N,N-diethyl-1-(4-hydroxyphenyl)-Cyclopropanecarboxamide Monohydrochloride; CS 1714; Cyclopropanecarboxamide, 2-(aminomethyl)-N,N-diethyl-1-(4-hydroxyphenyl)-, hydrochloride (1:1), (1R,2S)-; Cyclopropanecarboxamide, 2-(aminomethyl)-N,N-diethyl-1-(4-hydroxyphenyl)-, monohydrochloride, (1R,2S)-. CAS No. 688320-03-8. Molecular formula: C15H23ClN2O2. Mole weight: 298.81.
Rac,cis-Milnacipran Hydrochloride is an impurity of Milnacipran, which is a serotonin-norepinephrine reuptake inhibitor (SNRI) used in the clinical treatment of fibromyalgia. Synonyms: Milnacipran Methyl Amine Impurity HCl; cis-N,N-Diethyl-2-[(methylamino)methyl]-1-phenyl-cyclopropanecarboxamide Monohydrochloride; cis-(±)-N,N-Diethyl-2-[(methylamino)methyl]-1-phenyl-cyclopropanecarboxamide Monohydrochloride; Milnacipran Methyl Amine Hydrochloride; (1R,2S)-N,N-Diethyl-2-[(methylamino)methyl]-1-phenylcyclopropanecarboxamide hydrochloride (1:1); Cyclopropanecarboxamide, N,N-diethyl-2-[(methylamino)methyl]-1-phenyl-, (1R,2S)-, hydrochloride (1:1). Grades: ≥95%. CAS No. 165259-91-6. Molecular formula: C16H25ClN2O. Mole weight: 296.83.
SGC AAK1 1
SGC AAK1 1 is a potent and selective inhibitor of adaptor-associated protein kinase 1 (AAK1) and BMP-2-inducible protein kinase (BMP2K) inhibitor. It activates Wnt signaling. Synonyms: AAK1 inhibitor 1; N-(6-(3-((N,N-diethylsulfamoyl)amino)phenyl)-1H-indazol-3-yl)cyclopropanecarboxamide. Grades: ≥98% by HPLC. CAS No. 2247894-32-0. Molecular formula: C21H25N5O3S. Mole weight: 427.52.
Solcitinib
Solcitinib is an orally available JAK1 inhibitor with an IC50 of 9.8 nM. It has been investigated for the treatment of psoriasis, systemic lupus erythematosus, and ulcerative colitis. Synonyms: GSK 2586184; GSK-2586184; GLPG-0778; GLPG 0778; N-[5-[4-(3,3-dimethylazetidine-1-carbonyl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide. Grades: >98%. CAS No. 1206163-45-2. Molecular formula: C22H23N5O2. Mole weight: 389.459.
Ticagrelor Impurity 13
Ticagrelor Impurity 13. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (1R, 2R) -2- (3, 4-difluorophenyl) cyclopropanecarboxamide. CAS No. 1006376-62-0. Molecular Formula: C10H9F2NO. Mole Weight: 197.18. Catalog: APB1006376620.
VX-661
VX-661 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator used in combination with Ivacaftor in the treatment of cystic fibrosis. Synonyms: 1-(2,2-Difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1,1-dimethylethyl)-1H-indol-5-yl]cyclopropanecarboxamide; VX 661; VX661; Tezacaftor. Grades: 98%. CAS No. 1152311-62-0. Molecular formula: C26H27F3N2O6. Mole weight: 520.50.
Cabozantinib impurity 34
Cabozantinib impurity 34. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4- (4- (1- ( (4-fluorophenyl) carbamoyl) cyclopropanecarboxamido) phenoxy) -6, 7-dimethoxyquinoline 1-oxide. CAS No. 1621681-63-7. Molecular Formula: C28H24FN3O6. Mole Weight: 517.51. Catalog: APB1621681637.