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| Product | Description | |
|---|---|---|
| Ac-DEVD-CHO | Ac-DEVD-CHO is a potent aldehyde inhibitor of Group II caspases with Ki values of 0.2 nM and 0.3 nM for for caspase-3 and caspase-7, respectively. Weak inhibition for caspase-2. Uses: Cysteine proteinase inhibitors. Synonyms: N-acetyl-asp-glu-val-asp-al; Ac-Asp-Glu-Val-Asp-Aldehyde; L-Valinamide,N-acetyl-L-a-aspartyl-L-a-glutamyl-N-(2-carboxy-1-formylethyl)-. Grades: 95 %. CAS No. 169332-60-9. Molecular formula: C20H30N4O11. Mole weight: 502.47. |  |
| Ac-YVAD-CHO | Ac-YVAD-CHO is a selective inhibitor of interleukin-1β converting enzyme (ICE; Caspase-1). Uses: Cysteine proteinase inhibitors. Synonyms: Acetyl-tyrosyl-valyl-alanyl-aspartal; Ac-Tyr-Val-Ala-Asp-H; N-acetyl-Tyr-Val-Ala-Asp-aldehyde; (S)-N-Acetyl-L-tyrosyl-L-valyl-N-(2-carboxy-1-formylethyl)-L-alaninamide. Grades: ≥98%. CAS No. 143313-51-3. Molecular formula: C23H32N4O8. Mole weight: 492.52. | |
| Ac-YVAD-CMK | Ac-YVAD-CMK is a selective, irreversible inhibitor of interleukin-1β converting enzyme (ICE; Caspase-1). Ac-YVAD-CMK is neuroprotective in a rat model of cerebral ischemia. Uses: Cysteine proteinase inhibitors. Synonyms: Caspase 1 Inhibitor II. Grades: ≥98%. CAS No. 178603-78-6. Molecular formula: C24H33ClN4O8. Mole weight: 541. | |
| Adenovirus Proteinase Inhibitor, NSC 37249 (2- (Dicyclohexylamino) -N- (4- (4- ( (2- (dicyclohexylamino) acetyl) amino) phenyl) sulfonylphenyl) acetamide, N, N?- (Sulfonyldi-4, 1-phenylene) bis (2- (dicyclohexylamino) acetamide, AVP Inhibitor) | A sulfonyl diphenyl ene -bis-dicyclohexyl aminoacetamide compound that acts as a potent and selective inhibitor against adenovirus cysteine proteinase AVP by targeting simultaneously AVP co-factor pVIc (GVQSLKRRRCF) N-terminal binding pocket (Ki = 150nM) and AVP-pVIc substrate-binding site (Ki = 400nM), blocking both AVP-pVIc active complex formation (IC50 = 140nM; [substrate] = 5uM & [pVIc] = 40uM) and catalytic activity (IC50 = 490nM; [substrate] = 5uM) without affecting trypsin or papain protease activity even at concentrations as high as 10uM. Group: Biochemicals. Grades: Purified. CAS No. 2907-88-2. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?S. US Biological Life Sciences. |  Worldwide |
| CA 074 | CA 074 is a potent and selective inhibitor of cathepsin B (Ki = 2-5 nM). It reduces bone metastasis in a 4T1.2 breast cancer model. Uses: Cysteine proteinase inhibitors. Synonyms: CA-074; CA074; CA 074; N-[[(2S,3S)-3-[(Propylamino)carbonyl]-2-oxiranyl]carbonyl]-L-isoleucyl-L-proline. Grades: ≥98% by HPLC. CAS No. 134448-10-5. Molecular formula: C18H29N3O6. Mole weight: 383.44. | |
| Calpain Inhibitor II | Calpain inhibitor II is a cell-permeable inhibitor of calpain I (Ki = 120 nM), calpain II (Ki = 230 nM), cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 600 pM). It inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Calpain inhibitor II can block nitric oxide production by interfering with transcription of the inducible nitric oxide synthase gene, which is a weak inhibitor of proteasome. It has been used to demonstrate the involvement of ubiquitin-proteasome protein degradation in various biological systems. Uses: Cysteine proteinase inhibitors. Synonyms: L-Leucinamide, N-acetyl-L-leucyl-N-[(1S)-1-formyl-3-(methylthio)propyl]-; L-Leucinamide, N-acetyl-L-leucyl-N-[1-formyl-3-(methylthio)propyl]-, (S)-; N-Acetyl-L-leucyl-N-[(1S)-1-formyl-3-(methylthio)propyl]-L-leucinamide; ALLM; Calp II; CI 2; SUAM 312; N-acetylleucyl-leucyl-methioninal; Ac-Leu-Leu-Met-al; N-acetyl-L-leucyl-L-leucyl-L-methioninal. Grades: ≥98%. CAS No. 110115-07-6. Molecular formula: C19H35N3O4S. Mole weight: 401.57. | |
| Calpeptin | Calpeptin is a potent, cell-permeable calpain inhibitor with ID50 of 52 nM, 34 nM, 138 nM, and 40 nM for Calpain I (porcine erythrocytes), Calpain II (porcine kidney), Papainb, and Calpain I (human platelets), respectively. Uses: Cysteine proteinase inhibitors. Synonyms: Benzylcarbonyl-leu-nleu-H; Cbz-Leu-Nle-al. Grades: >98%. CAS No. 117591-20-5. Molecular formula: C20H30N2O4. Mole weight: 362.46. | |
| Cathepsin K from Human, recombinant | Cathepsin K, a member of the papain cysteine proteinase family is the predominant proteinase responsible for the resorption of the bone matrix. Cathepsin cleaves proteins such as collagen type I, collagen type II and osteonectin, thereby playing a role in bone remodeling and resorption in osteoporosis, osteolytic bone metastasis and rheumatoid arthritis. Group: Enzymes. Synonyms: CTSK; CTSO; CTSO3; Cathepsin O; Cathepsin O2; Cathepsin X; EC 3.4.22.38. Enzyme Commission Number: EC 3.4.22.38. CAS No. 94716-09-3. Purity: > 95% by SDS-PAGE. Activity: >900 mU/mg protein. Storage: at -80°C. Avoid freeze/thaw. Form: Liquid. Source: E. coli. Species: Human. CTSK; CTSO; CTSO3; Cathepsin O; Cathepsin O2; Cathepsin X; EC 3.4.22.38. Cat No: NATE-1705. |  |
| Cathepsin K from Mouse, recombinant | Cathepsin K, a member of the papain cysteine proteinase family is the predominant proteinase responsible for the resorption of the bone matrix. Cathepsin cleaves proteins such as collagen type I, collagen type II and osteonectin, thereby playing a role in bone remodeling and resorption in osteoporosis, osteolytic bone metastasis and rheumatoid arthritis. Group: Enzymes. Synonyms: CTSK; CTSO; CTSO3; Cathepsin O; Cathepsin O2; Cathepsin X; EC 3.4.22.38. Enzyme Commission Number: EC 3.4.22.38. CAS No. 94716-09-3. Purity: > 90% by SDS-PAGE. Mole weight: 23.4 kDa (115-329 aa). Activity: >1000 mU/mg. Storage: Stable for 6 months at -80°C. Use as provided or dilute to 0.1 mg/ml with 50% glycerol. Aliquot and store at -80°C. Avoid repeated freezing and thawing cycles, as this may lead to the loss in its activity over time. Form: Liquid. Source: E. coli. Species: Mouse. CTSK; CTSO; CTSO3; Cathepsin O; Cathepsin O2; Cathepsin X; EC 3.4.22.38. Cat No: NATE-1704. | |
| Cathepsin K from Rat, recombinant | Cathepsin K, a member of the papain cysteine proteinase family is the predominant proteinase responsible for the resorption of the bone matrix. Cathepsin cleaves proteins such as collagen type I, collagen type II and osteonectin, thereby playing a role in bone remodeling and resorption in osteoporosis, osteolytic bone metastasis and rheumatoid arthritis. Group: Enzymes. Synonyms: CTSK; CTSO; CTSO3; Cathepsin O; Cathepsin O2; Cathepsin X; EC 3.4.22.38. Enzyme Commission Number: EC 3.4.22.38. CAS No. 94716-09-3. Purity: > 90% by SDS-PAGE. Mole weight: 23.5 kDa (115-329 aa). Activity: >500 mU/mg. Storage: Stable for 6 months at -80°C. Use as provided or dilute to 0.1 mg/ml with 50% glycerol. Aliquot and store at -80°C. Avoid repeated freezing and thawing cycles, as this may lead to the loss in its activity over time. Form: Liquid. Source: E. coli. Species: Rat. CTSK; CTSO; CTSO3; Cathepsin O; Cathepsin O2; Cathepsin X; EC 3.4.22.38. Cat No: NATE-1703. | |
| cathepsin L | A lysosomal enzyme in peptidase family C1 (papain family) that is readily inhibited by the diazomethane inhibitor Z-Phe-Phe-CHN2 or the epoxide inhibitor E-64. Group: Enzymes. Synonyms: Aldrichina grahami cysteine proteinase. Enzyme Commission Number: EC 3.4.22.15. CAS No. 60616-82-2. CTSL. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4195; cathepsin L; EC 3.4.22.15; 60616-82-2; Aldrichina grahami cysteine proteinase. Cat No: EXWM-4195. | |
| Cathepsin L from Human, Recombinant | Cathepsin L (EC 3.4.22.15, Aldrichina grahami cysteine proteinase) is an important lysosomal endopeptidase enzyme which is involved in the initiation of protein degradation. It is a member of the Peptidase C1 family, which play an important role in diverse processes including normal lysosome mediated protein turnover, antigen and proprotein processing, and apoptosis. Cathepsin L has been reported in many organisms including fish, birds and mammals. Group: Enzymes. Synonyms: Cathepsin L1; Major excreted protein; Cathepsin U; Cathepsin V. Enzyme Commission Number: EC 3.4.22.15. Purity: > 90% by SDS-PAGE. CTSL. Mole weight: 24.2 kDa (114-333 aa). Activity: > 10000 mU/mg. Stability: Stable for at least 6 months as supplied. Use as provided or dilute with 50% glycerol to 0.1 mg/ml. Aliquot immediately and store at -80°C. Avoid freeze/thaw cycles. Storage: Store at -80°C. Form: Liquid. Source: E. coli. Species: Human. cathepsin L; CTSL; EC 3.4.22.15; Aldrichina grahami cysteine proteinase; 60616-82-2; Cathepsin L1; Major excreted protein; Cathepsin U; Cathepsin V. Cat No: NATE-1665. | |
| E-64 | E-64 is an irreversible and selective cysteine protease inhibitor with IC50 of 9 nM for papain. Uses: For research used only. Synonyms: L-trans-Epoxysuccinyl-Leu-4-guanidinobutylamide; Proteinase inhibitor E 64; 3-[[[ (1S) -1-[[[4-[ (aminoiminomethyl) amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]- (2S, 3S) -oxiranecarboxylic acid; Thiol protease inhibitor; trans-Epoxysuccinyl-L-leucylamido-(4-guanidino)butane; 2-Oxiranecarboxylic acid, 3-[[[ (1S) -1-[[[4-[ (aminoiminomethyl) amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-, (2S,3S)-; L-Trans-Epoxysuccinyl-Leu-agmatine. Grades: ≥99% by HPLC. CAS No. 66701-25-5. Molecular formula: C15H27N5O5. Mole weight: 357.41. | |
| E-64 | E-64 (Proteinase inhibitor E 64) is a potent irreversible inhibitor against general cysteine proteases with IC 50 of 9 nM for papain. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Proteinase inhibitor E 64. CAS No. 66701-25-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15282. |  |
| gingipain R | A secreted endopeptidase from the bacterium Porphyromonas gingivalis. Strongly activated by glycine, and stabilized by Ca2+. Precursor molecule contains a hemagglutinin domain. Misleadingly described in some literature as "trypsin-like", being a cysteine peptidase, type example of family C25. Group: Enzymes. Synonyms: Arg-gingipain; gingipain-1; argingipain; Arg-gingivain-55 proteinase; Arg-gingivain-70 proteinase; Arg-gingivain-75 proteinase; arginine-specific cysteine protease; arginine-specific gingipain; arginine-specific gingivain; RGP-1; RGP. Enzyme Commission Number: EC 3.4.22.37. CAS No. 159745-71-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4212; gingipain R; EC 3.4.22.37; 159745-71-8; Arg-gingipain; gingipain-1; argingipain; Arg-gingivain-55 proteinase; Arg-gingivain-70 proteinase; Arg-gingivain-75 proteinase; arginine-specific cysteine protease; arginine-specific gingipain; arginine-specific gingivain; RGP-1; RGP. Cat No: EXWM-4212. | |
| Granzyme B from Mouse, Recombinant | Granzyme B, a 247 amino acid polypeptide, contains a leader sequence, which is cleaved by a signal peptidase and a two amino acid prodomain, which is cleaved by the lysosomal cysteine protease DPPI. The recombinant granzyme B is expressed in Pichia pastoris as the mature form and appears on SDS-PAGE as a triplet (~34, 32, and 30 kDa) due to three different glycosylations. Granzyme B, a serine protease, is the most prominent granzyme in a family of 11 found in the cytotoxic granules. The granzymes enter the target cell with the assistance of perforin, a critical molecule of the cytotoxic granules. In the target cell, the granzymes act on specific substrates involved with the cell death via apoptosis. > 90% (sds-page), recombinant, expressed in pichia pastoris, buffered aqueous solution. pichia expressed recombinant granzyme b has the advantage over native granzyme b as the latter can be purified only in limited amounts, and over e. coli and vaccinia virus expressed enzymes that failed to generate soluble active enzyme. Group: Enzymes. Synonyms: g. CAS No. 143180-74-9. Granzyme B. Mole weight: 28.9 kDa. Activity: > 10,000 units/mg protein. Storage: -70°C. Form: buffered aqueous solution. Source: Pichia pastoris. Species: Mouse. granzyme B; CTLA1; CCPII; cytotoxic cell proteinase-1; granzyme G; granzyme H; CCP1 proteinase; GzmB. Cat No: NATE-0333. | |
| helper-component proteinase | Known from many potyviruses. The helper component-proteinase of the tobacco etch virus is a multifunctional protein with several known activities: the N-terminal region is required for aphid transmission and efficient genome amplification, the central region is required for long-distance movement in plants, and the C-terminal domain has cysteine endopeptidase activity. Type example of peptidase family C6. Group: Enzymes. Synonyms: HC-Pro. Enzyme Commission Number: EC 3.4.22.45. CAS No. 124566-20-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4220; helper-component proteinase; EC 3.4.22.45; 124566-20-7; HC-Pro. Cat No: EXWM-4220. | |
| histolysain | From the protozoan, Entamoeba histolytica. In peptidase family C1 (papain family). Group: Enzymes. Synonyms: histolysin; histolysin; Entamoeba histolytica cysteine proteinase; amebapain; Entamoeba histolytica cysteine protease; Entamoeba histolytica neutral thiol proteinase. Enzyme Commission Number: EC 3.4.22.35. CAS No. 92228-52-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4210; histolysain; EC 3.4.22.35; 92228-52-9; histolysin; histolysin; Entamoeba histolytica cysteine proteinase; amebapain; Entamoeba histolytica cysteine protease; Entamoeba histolytica neutral thiol proteinase. Cat No: EXWM-4210. | |
| kexin | A Ca2+-activated peptidase of peptidase family S8, containing Cys near the active site His, and inhibited by p-mercuribenzoate. Similar enzymes occur in mammals. Group: Enzymes. Synonyms: yeast KEX2 protease; proteinase yscF; prohormone-processing endoprotease; paired-basic endopeptidase; yeast cysteine proteinase F (misleading); paired-basic endopeptidase; andrenorphin-Gly-generating enzyme; endoproteinase Kex2p; gene KEX2 dibasic proteinase; Kex 2p proteinase; Kex2 endopeptidase; Kex2 endoprotease; Kex2 endoproteinase; Kex2 protease; proteinase Kex2p; Kex. Enzyme Commission Number: EC 3.4.21.61. CAS No. 99676-46-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4152; kexin; EC 3.4.21.61; 99676-46-7; yeast KEX2 protease; proteinase yscF; prohormone-processing endoprotease; paired-basic endopeptidase; yeast cysteine proteinase F (misleading); paired-basic endopeptidase; andrenorphin-Gly-generating enzyme; endoproteinase Kex2p; gene KEX2 dibasic proteinase; Kex 2p proteinase; Kex2 endopeptidase; Kex2 endoprotease; Kex2 endoproteinase; Kex2 protease; proteinase Kex2p; Kex2-like precursor protein processing endoprotease; prohormone-processing KEX2 proteinase; prohormone-processing proteinase; proprotein convertase; protease KEX2; Kex2 proteinase; Kex2-like endoproteinase. Cat No: EXWM-4152. | |
| Leupeptin | Leupeptin reversibly inhibits serine proteinases (trypsin (Ki=3.5 nM), plasmin (Ki= 3.4 nM), porcine kallikrein), and cysteine proteinases (papain, cathepsin B (Ki = 4.1 nM), endoproteinase Lys-C). Leupeptin has been shown to inhibit activation-induced programmed cell death. Synonyms: 2-(2-acetamido-4-methylvaleramido)-n-(1-formyl-4-guanidinobutyl)-4-methylval; 2-(2-acetamido-4-methylvaleramido)-n-(1-formyl-4-guanidinobutyl)-4-valeramid; leupeptinac-ll; l-leucinamide,n-acetyl-l-leucyl-n-(4-((aminoiminomethyl)amino)-1-formylbutyl; Leupeptin; Leupeptin Ac-LL; N-Acetyl-L-leucyl-L-leucyl-L-argininal; NK-381; NK 381; NK381. Grades: >98%. CAS No. 24365-47-7. Molecular formula: C20H38N6O4. Mole weight: 426.55. | |
| Native Human Cathepsin H | Cathepsin H is a protein that in humans is encoded by the CTSH gene. The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. Two transcript variants encoding different isoforms have been found for this gene. Group: Enzymes. Synonyms: CTSH; cathepsin H; CPSB; ACC-4; ACC-5; ACC4; ACC5; CPSB; minichain. Purity: > 95% (SDS-PAGE). CTSH. Mole weight: 28 kDa. Storage: -40°C. Form: Liquid. Source: Human Liver. Species: Human. CTSH; cathepsin H; CPSB; ACC-4; ACC-5; ACC4; ACC5; CPSB; minichain. Cat No: NATE-0176. | |
| Native Human Cathepsin L | Cathepsin L (EC 3.4.22.15, Aldrichina grahami cysteine proteinase) is an important lysosomal endopeptidase enzyme which is involved in the initiation of protein degradation. It is a member of the Peptidase C1 family, which play an important role in diverse processes including normal lysosome mediated protein turnover, antigen and proprotein processing, and apoptosis. Cathepsin L has been reported in many organisms including fish, birds and mammals. Applications: The most powerful of the lysosomal proteinases. it has a higher specific activity than cathepsin b and h in the degradation of a variety of physiological protein substrates. Group: Enzymes. Synonyms: cathepsin L; CTSL; EC 3.4.22.15; Aldrichina grahami cysteine proteinase; 60616-82-2. Enzyme Commission Number: EC 3.4.22.15. CAS No. 60616-82-2. CTSL. Activity: > 0.5 units/mg protein. Storage: -20°C. Form: Solution in in 20 mM malonate, pH 5.5, 1 mM EDTA, and 400 mM NaCl. Source: Human liver. Species: Human. cathepsin L; CTSL; EC 3.4.22.15; Aldrichina grahami cysteine proteinase; 60616-82-2. Cat No: NATE-0177. | |
| Native Papaya latex Chymopapain | Chymopapain is a proteolytic enzyme isolated from the latex of papaya (Carica papaya). It is a medication used to treat herniated lower lumbar discs in the spine. Chymopapain injections are normally given under local, Rather than general, anaesthesia. The dose for a single intervertebral disc is 2 to 4 nanokatals, with a maximum dose per patient of 8 nanokatals. The procedure is referred to as chemonucleolysis. Applications: Chymopapain from papaya latex has been used in a study to assess the anthelmintic effect of natural plant cysteine proteinases against the gastrointestinal nematode, heligmosomoides. chymopapain from papaya latex has also been used in a study to investiga...enzyme has been used along with pronase, collagenase, elastase, dnase, and catalase for rabbit lung cells digestion at a concentration of 0.05% in calcium-magnesium-free kreb?s serum substitute. it has also been used for the release of neuroblastoma cells from marrow bound to antibody-coated microspheres. Group: Enzymes. Synonyms: chymopapain A; chymopapain B; chymopapain S; EC 3.4.22.6; 9001-09-6; Chymodiactin. Enzyme Commission Number: EC 3.4.22.6. CAS No. 9001-9-6. Chymopapain. Activity: > 2.0 units/mg protein. Storage: -20°C. Form: lyophilized powder. Source: Papaya latex. chymopapain A; chymopapain B; chymopapain S; EC 3.4.22.6; 9001-09-6; Chymodiactin. Cat No: NATE-0133. | |
| Native Staphylococcus aureus Staphopain A | Staphopains A and B are part of the staphylococcal proteolytic cascade (SPC) and may contribute to tissue invasion and metastatic infections of Staphylococcus aureus. Staphopain A, along with Staphopain B, may contribute to septic shock through the release of bradykinin and S-kinin from human kininogens. This activity required proteolytically-active Staphopain A and was augmented by Staphopain B. Staphopain a is inhibited by staphostatin a, e-64, and heavy metal ions such as hg2+ and ag+. staphopain a is also inhibited by plasma α2-macroglobulin but not by human cystatin c. staphopain a and staphopain b, members of the peptidase c47 family, are the major cysteine proteases secreted by s. aureus. Applications: Staphopain a was used for cleaving the n terminus of atypical chemokine receptor (ackr2) to suppress its ligand internalization activity in a study on the pivotal role of ackr2 in ligand binding, internalization and scavenging of inflammatory responses. Group: Enzymes. Synonyms: Staphopain; EC 3.4.2. Enzyme Commission Number: EC 3.4.22.48. CAS No. 347841-89-8. Staphopain. Mole weight: mol wt ~20 kDa by SDS-PAGE. Storage: -20°C. Form: lyophilized powder. Source: Staphylococcus aureus. Staphopain; EC 3.4.22.48; staphylopain; 347841-89-8; ScpA; Staphopain A; Staphylococcal cysteine proteinase A; Staphylopain A. Cat No: NATE-0666. | |
| Native Staphylococcus aureus Staphopain B | Staphopains A and B are part of the staphylococcal proteolytic cascade (SPC) and may contribute to tissue invasion and metastatic infections of Staphylococcus aureus. Staphopain A, along with Staphopain B, may contribute to septic shock through the release of bradykinin and S-kinin from human kininogens. This activity required proteolytically-active Staphopain A and was augmented by Staphopain B. Staphopain activity is inhbited by staphostatin b (sspc) and e-64. staphopain activity is stimulated by edta. staphopain a and staphopain b, members of the peptidase c47 family, are the major cysteine proteases secreted by s. aureus. Group: Enzymes. Synonyms: Staphopain; EC 3.4.22.48; staphylopain; 347841-89-8; Staphopain B; Staphylococcal cysteine proteinase B; Staphylopain B; sspB. Enzyme Commission Number: EC 3.4.22.48. CAS No. 347841-89-8. Purity: > 95% (SDS-PAGE). Staphopain. Mole weight: mol wt ~20 kDa by SDS-PAGE. Storage: -20°C. Source: Staphylococcus aureus. Staphopain; EC 3.4.22.48; staphylopain; 347841-89-8; Staphopain B; Staphylococcal cysteine proteinase B; Staphylopain B; sspB. Cat No: NATE-0683. | |
| oryzin | A peptidase of family S8 (subtilisin family), not containing cysteine, that is the predominant extracellular alkaline endopeptidase of the mold Aspergillus oryzae.Identical or closely related enzymes are produced by A. flavus and A. sojae. Group: Enzymes. Synonyms: Aspergillus alkaline proteinase; aspergillopeptidase B; API 21; aspergillopepsin B; aspergillopepsin F; Aspergillus candidus alkaline proteinase; Aspergillus flavus alkaline proteinase; Aspergillus melleus semi-alkaline proteinase;. Enzyme Commission Number: EC 3.4.21.63. CAS No. 9074-7-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4154; oryzin; EC 3.4.21.63; 9074-07-1; Aspergillus alkaline proteinase; aspergillopeptidase B; API 21; aspergillopepsin B; aspergillopepsin F; Aspergillus candidus alkaline proteinase; Aspergillus flavus alkaline proteinase; Aspergillus melleus semi-alkaline proteinase; Aspergillus oryzae alkaline proteinase; Aspergillus parasiticus alkaline proteinase; Aspergillus serine proteinase; Aspergillus sydowi alkaline proteinase; Aspergillus soya alkaline proteinase; Aspergillus melleus alkaline proteinase; Aspergillus sulphureus alkaline proteinase; prozyme; P 5380; kyorinase; seaprose S; semi-alkaline protease; sumizyme MP; prozyme 10; onoprose; onoprose SA; protease P; promelase. Cat No: EXWM-4154. | |
| picornain 3C | From entero-, rhino-, aphto- and cardioviruses. Larger than the homologous virus picornain 2A. Type example of peptidase family C3. Group: Enzymes. Synonyms: picornavirus endopeptidase 3C; poliovirus protease 3C; rhinovirus protease 3C; foot-and-mouth protease 3C; poliovirus proteinase 3C; rhinovirus proteinase 3C; coxsackievirus 3C proteinase; foot-and-mouth-disease virus proteinase 3C; 3C protease; 3C proteinase; cysteine proteinase 3C; hepatitis A virus 3C proteinase; protease 3C; tomato ringspot nepovirus 3C-related protease. Enzyme Commission Number: EC 3.4.22.28. CAS No. 97162-88-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4202; picornain 3C; EC 3.4.22.28; 97162-88-4; picornavirus endopeptidase 3C; poliovirus protease 3C; rhinovirus protease 3C; foot-and-mouth protease 3C; poliovirus proteinase 3C; rhinovirus proteinase 3C; coxsackievirus 3C proteinase; foot-and-mouth-disease virus proteinase 3C; 3C protease; 3C proteinase; cysteine proteinase 3C; hepatitis A virus 3C proteinase; protease 3C; tomato ringspot nepovirus 3C-related protease. Cat No: EXWM-4202. | |
| Protease Inhibitor Library | A unique collection of 344 protease and proteasome inhibitors for research in chemical genomics, and drug screening; - Targets include proteasome, DPP-4, Serine protease, cysteine protease, MMP, Aspartic proteinases, etc; - Bioactivity and safety confirmed by pre-clinical research and clinical trials, and some of them are approved by FDA; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L1100. Categories: Protease Inhibitor Libraries. |  |
| saccharolysin | An 83 kDa cytoplasmic thiol-dependent metalloendopeptidase from Saccharomyces cerevisiae. In peptidase family M3 (thimet oligopeptidase family). Group: Enzymes. Synonyms: proteinase yscD; yeast cysteine proteinase D (Misleading); Saccharomyces cerevisiae proteinase yscD. Enzyme Commission Number: EC 3.4.24.37. CAS No. 96779-48-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4319; saccharolysin; EC 3.4.24.37; 96779-48-5; proteinase yscD; yeast cysteine proteinase D (Misleading); Saccharomyces cerevisiae proteinase yscD. Cat No: EXWM-4319. | |
| Stem bromelain | Stem bromelain (EC 3.4.22.32) is a cysteine proteinase, isolated from pineapple ( Ananas comosus ) stem. Stem bromelain is a major bromelain, which exhibits various fibrinolytic, antiedematous, antithrombotic, and anti-inflammatory activities. Stem bromelain has in vivo antitumoral and antileukemic activity, as well as antimetastatic action [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 37189-34-7. Pack Sizes: 5 g; 25 g; 100 g. Product ID: HY-P2970. | |
| streptopain | From the bacterium, group A Streptococcus. Formed from the proenzyme by limited proteolysis. Type example of peptidase family C10. Group: Enzymes. Synonyms: Streptococcus peptidase A; streptococcal cysteine proteinase; Streptococcus protease. Enzyme Commission Number: EC 3.4.22.10. CAS No. 9025-51-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4193; streptopain; EC 3.4.22.10; 9025-51-8; Streptococcus peptidase A; streptococcal cysteine proteinase; Streptococcus protease. Cat No: EXWM-4193. | |
| subtilisin | Subtilisin is a serine endopeptidase, type example of peptidase family S8. It contains no cysteine residues (although these are found in homologous enzymes). Species variants include subtilisin BPN' (also subtilisin B, subtilopeptidase B, subtilopeptidase C, Nagarse, Nagarse proteinase, subtilisin Novo, bacterial proteinase Novo) and subtilisin Carlsberg (subtilisin A, subtilopeptidase A, alcalase Novo). Similar enzymes are produced by various Bacillus subtilis strains and other Bacillus species. Group: Enzymes. Synonyms: alcalase; alcala. Enzyme Commission Number: EC 3.4.21.62. CAS No. 9014-1-1. Protease. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4153; subtilisin; EC 3.4.21.62; 9014-01-1; alcalase; alcalase 0.6L; alcalase 2.5L; ALK-enzyme; bacillopeptidase A; bacillopeptidase B; Bacillus subtilis alkaline proteinase bioprase; bioprase AL 15; bioprase APL 30; colistinase; (see also comments); subtilisin J; subtilisin S41; subtilisin Sendai; subtilisin GX; subtilisin E; subtilisin BL; genenase I; esperase; maxatase; alcalase; thermoase PC 10; protease XXVII; thermoase; superase; subtilisin DY; subtilopeptidase; SP 266; savinase 8.0L; savinase 4.0T; kazusase; protease VIII; opticlean; Bacillus subtilis alkaline proteinase; protin A 3L; savinase; savinase 16.0L; savinase 32.0 L EX | |
| TMC-52A | TMC-52A is a cysteine proteinase inhibitor produced by Gliocladium sp. F-2665. It strongly inhibited cysteine proteinases, in particular, cathepsin L with IC50 value of 13 nM. Synonyms: TMC-52 A. Molecular formula: C20H30N4O6. Mole weight: 422.5. | |
| TMC-52B | TMC-52B is a cysteine proteinase inhibitor produced by Gliocladium sp. F-2665. It strongly inhibited cysteine proteinases, in particular, cathepsin L with IC50 value of 10 nM. Synonyms: TMC-52 B. Molecular formula: C20H30N4O6. Mole weight: 422.5. | |
| TMC-52C | TMC-52C is a cysteine proteinase inhibitor produced by Gliocladium sp. F-2665. It strongly inhibited cysteine proteinases, in particular, cathepsin L with IC50 value of 10 nM. Synonyms: TMC-52 C. Molecular formula: C20H30N4O5. Mole weight: 406.5. | |
| TMC-52D | TMC-52D is a cysteine proteinase inhibitor produced by Gliocladium sp. F-2665. It strongly inhibited cysteine proteinases, in particular, cathepsin L with IC50 value of 6 nM. Synonyms: TMC-52 D. Molecular formula: C20H30N4O5. Mole weight: 406.5. | |
| Z-DEVD-FMK | Z-DEVD-FMK is a cell-permeant, irreversible caspase-3 inhibitor that can be used as an anaesthetic agent. It has been shown to suppress tumor cell apoptosis. Uses: Cysteine proteinase inhibitors. Synonyms: Z-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-FMK; Caspase-3 Inhibitor; Z-D(OMe)E(Ome)VD(OMe)-FMK; benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethylketone; Caspase-3 Inhibitor II; Z-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-Fluoromethylketone; Z-DEVD-fluoromethylketone. Grades: ≥95%. CAS No. 210344-95-9. Molecular formula: C30H41FN4O12. Mole weight: 668.67. | |
| Z-Ile-Glu(O-t-butyl)-Ala-Leucinal | PSI is a drug that blocks the action of proteasomes, protein complexes that degrade unneeded and damaged proteins. It causes dopaminergic cell death in vitro and prevents activation of NF-κB in response to TNF-α and okadaic acid by inhibiting IκB-α degradation. Uses: Cysteine proteinase inhibitors. Synonyms: Proteasome Inhibitor I; PSI peptide; L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-isoleucyl-L-alpha-glutamyl-N-[(1S)-1-formyl-3-methylbutyl]-, 1,1-dimethylethyl ester. Grades: ≥ 90 % by HPLC. CAS No. 158442-41-2. Molecular formula: C32H50N4O8. Mole weight: 618.76. | |
| Z-Leu-Arg-AMC | Z-Leu-Arg-AMC is a 4-methylcoumarinyl-7-amide (Amc) leucine derivative with carboxybenzoyl (Z). Z-Leu-Arg-AMC is the active site of cysteine proteinase trypanopain-Tb from Trypanosoma brucei brucei [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 156192-32-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-142021. | |
| Z-LVG-CHN2 | Z-LVG-CHN2 is a tripeptide derivative that mimics part of the human cysteine proteinase-binding center. Z-LVG-CHN2 effectively blocks SARS-COV-2 replication (EC50 = 190 nM) via inhibition of SARS-COV-2 3CL pro protease. Synonyms: L-Valinamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-(3-diazo-2-oxopropyl)-(9CI); Z-LVG-DMK. Grades: 95%. CAS No. 119670-30-3. Molecular formula: C22H31N5O5. Mole weight: 445.51. | |
| Z-Phe-DL-Ala-FMK | Z-FA-FMK is an irreversible cysteine protease inhibitor, and it also inhibits caspases-2, -3, -6, and -7. Z-FA-FMK suppresses the degradation of fibrillar collagen by fibroblasts and osteoclasts, and reduces LPS-induced cytokine production via inhibition of NF-kappaB-dependent gene expression in macrophages. Uses: Cysteine proteinase inhibitors. Synonyms: Z-Phe-DL-Ala-fluoromethylketone; Zfa-fmk; benzyloxycarbonyl-Phe-Ala-fluormethylketone; benzyloxycarbonylphenylalanyl-alanine fluoromethyl ketone; Carbamic acid, N-((1S)-2-((3-fluoro-1-methyl-2-oxopropyl)amino)-2-oxo-1-(phenylmethyl)ethyl)-, phenylmethyl ester. Grades: ≥95%. CAS No. 197855-65-5. Molecular formula: C21H23FN2O4. Mole weight: 386.42. | |
| Parstatin (mouse) | Parstatin, a 41-mer peptide which is cleaved upon activation of Proteinase-Activated Receptor 1, attenuates endothelial cell migration and proliferation (IC50 ~ 20 μM), and induces cell cycle arrest. It promotes activation of caspase-3 and exhibits pro-apoptotic activity in vitro. Synonyms: H-Met-Gly-Pro-Arg-Arg-Leu-Leu-Ile-Val-Ala-Leu-Gly-Leu-Ser-Leu-Cys-Gly-Pro-Leu-Leu-Ser-Ser-Arg-Val-Pro-Met-Ser-Gln-Pro-Glu-Ser-Glu-Arg-Thr-Asp-Ala-Thr-Val-Asn-Pro-Arg-OH; L-methionyl-glycyl-L-prolyl-L-arginyl-L-arginyl-L-leucyl-L-leucyl-L-isoleucyl-L-valyl-L-alanyl-L-leucyl-glycyl-L-leucyl-L-seryl-L-leucyl-L-cysteinyl-glycyl-L-prolyl-L-leucyl-L-leucyl-L-seryl-L-seryl-L-arginyl-L-valyl-L-prolyl-L-methionyl-L-seryl-L-glutaminyl-L-prolyl-L-alpha-glutamyl-L-seryl-L-alpha-glutamyl-L-arginyl-L-threonyl-L-alpha-aspartyl-L-alanyl-L-threonyl-L-valyl-L-asparagyl-L-prolyl-L-arginine. Grades: ≥98%. CAS No. 1065756-01-5. Molecular formula: C189H326N58O57S3. Mole weight: 4419.19. | |
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