Desaturase Suppliers USA
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Product | Description | |
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Stearoyl CoA Desaturase 1 Inhibitor (4- (2-Chlorophenoxy) -N- (3- (3-methylcarbamoyl) phenyl) piperidine-1-carboxamide, SCD1 Inhibitor) Quick inquiry Where to buy Suppliers range | Cell-permeable. A potent and selective inhibitor of SCD1(stearoyl-CoA desaturase 1) (In vitro: IC50 = 37nM for hSCD1, < 4nM for mSCD1). Also exhibited in vivo efficacy with dose-dependent desaturation index lowering effect. SCD1 inhibition resulted in alterationsin macrophage membrane lipid composition and marked hypersensitivity to toll-like receptor 4 agonists. Group: Biochemicals. Alternative Names: 4- (2-Chlorophenoxy) -N- (3- (3-methylcarbamoyl) phenyl) piperidine-1-carboxamide. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
Stearoyl-CoA Desaturase 1 Inhibitor, MF-438 (2-methyl-5- (6- (4- (2- (trifluoromethyl) phenoxy) piperidin-1-yl) pyridazin-3-yl) -1, 3, 4-thiadiazole) Quick inquiry Where to buy Suppliers range | A cell-permeable, thiadiazole-pyridazine compound that acts as an inhibitor of Stearoyl-CoA Desaturase 1 (SCD1) with an IC50 of 2.3nM. In vivo, it exhibits an ED50 of 1-3mg/kg, p.o., in mouse liver PD assays. Group: Biochemicals. Grades: Highly Purified. CAS No. 921605-87-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
10(E),12(Z)-Conjugated linoleic acid Quick inquiry Where to buy Suppliers range | Conjugated linoleic acid (CLA) refers to a family of 8 geometric isomers of linoleic acid in which the two double bonds are contiguous. (The predominant form of linoleic acid in nature, 18:ω6, has double bonds at 9 and 12, interrupted by a methylene carbon.) CLA is found in both meat and dairy products, but it is not found to any significant degree in plants. Various antioxidant and antitumor activities have been attributed to CLA or its downstream metabolites. Reported health benefits of dietary supplementation with CLA have been attributed variously to competitive inhibition of Δ6-desaturase and/or PPARγ activation. Synonyms: 10E,12Z-CLA; 10E,12Z-octadecadienoic acid. Grades: ≥98%. CAS No. 2420-56-6. Molecular formula: C18H32O2. Mole weight: 280.5. | |
1-(2-Chloro-6-hydroxyphenyl)ethanone Quick inquiry Where to buy Suppliers range | 1-(2-Chloro-6-hydroxyphenyl)ethanone is used for synthesis and structure-activity relationship of novel spiropiperidine-based stearoyl-CoA desaturase-1 inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 55736-04-4. Pack Sizes: 50mg, 100mg. Molecular Formula: C8H7ClO2, Molecular Weight: 170.59. US Biological Life Sciences. | Worldwide |
1-Iodo-3,5-bis(trifluoromethyl)-benzene Quick inquiry Where to buy Suppliers range | 1-Iodo-3,5-bis(trifluoromethyl)-benzene is a useful synthetic intermediate. It can be used to prepare stearoyl-CoA desaturase-1 inhibitors and cholesteryl ester transfer protein inhibitors. It is also used to synthesize Flupropadine (F500750), a sub-acute rodenticide. Group: Biochemicals. Grades: Highly Purified. CAS No. 328-73-4. Pack Sizes: 10g, 25g. Molecular Formula: C8H3F6I, Molecular Weight: 340. US Biological Life Sciences. | Worldwide |
2-Amino-5-(trifluoromethyl)-4-thiazolecarboxylic Acid Quick inquiry Where to buy Suppliers range | 2-Amino-5-(trifluoromethyl)-4-thiazolecarboxylic Acid is a derivative of 2-Aamino-4-thiazolecarboxylic Acid Ethyl Ester (E678465), a chemical reagent used in the preparation fo SAR thiazolamino arylaminopyrimidines as anaplastic lymphoma kinase inhibitors. As well as in the synthesis of 4-bicyclick piperadine derivatives as potent stearoyl-CoA desaturase (SCD1) inhibitors in the treatment of cancer. Group: Biochemicals. Grades: Highly Purified. CAS No. 1086380-23-5. Pack Sizes: 10mg, 100mg. Molecular Formula: C5H3F3N2O2S, Molecular Weight: 212.15. US Biological Life Sciences. | Worldwide |
(2R)-Tetrahydro-2-furanmethanamine Hydrochloride Quick inquiry Where to buy Suppliers range | (2R)-Tetrahydro-2-furanmethanamine is a stereoisomer of Tetrahydro-2-furanmethanamine (T293545) which is used in the synthesis of novel topoisomerase I targeting anti-cancer agents with mild to potent cytotoxic activity. Tetrahydro-2-furanmethanamine (T293545) is also used in the discovery and synthesis of orally bioavailable stearoyl-CoA desaturase 1 inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 7175-80-6. Pack Sizes: 1g, 10g. Molecular Formula: C5H11NO HCl. US Biological Life Sciences. | Worldwide |
(2S)-Tetrahydro-2-furanmethanamine Hydrochloride Quick inquiry Where to buy Suppliers range | (2S)-Tetrahydro-2-furanmethanamine Hydrochloride is a stereoisomeric salt of Tetrahydro-2-furanmethanamine (T293545) which is used in the synthesis of novel topoisomerase I targeting anti-cancer agents with mild to potent cytotoxic activity. Tetrahydro-2-furanmethanamine (T293545) is also used in the discovery and synthesis of orally bioavailable stearoyl-CoA desaturase 1 inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 21801-94-5. Pack Sizes: 100mg, 500mg. Molecular Formula: C5H12ClNO. US Biological Life Sciences. | Worldwide |
8,11-Eicosadiynoic acid Quick inquiry Where to buy Suppliers range | 8,11-Eicosadiynoic acid is an acetylenic fatty acid which inhibits arachidonic acid metabolism at several unrelated stages. 8,11-Eicosadiynoic acid inhibits the enzymes, arachidonoyl synthase, acyl-CoA synthase, Δ-5-desaturase, COX, and also arachidonic acid uptake by platelets. Synonyms: EDYA; Eicosa-8,11-diynoic acid. Grades: ≥95%. CAS No. 82073-91-4. Molecular formula: C20H32O2. Mole weight: 304.5. | |
A939572 Quick inquiry Where to buy Suppliers range | A939572 is a effective and highly selective cell-permeable inhibitor of SCD1(stearoyl-CoA desaturase 1) which could be mediated by hormonal and dietary actions. It is under early phase clinical trials for its potential effect in obesity and diabetes. IC50. Uses: A939572 is a effective and highly selective cell-permeable inhibitor of scd1(stearoyl-coa desaturase 1) which could be mediated by hormonal and dietary actions. Synonyms: A939572; A-939572; A 939572. SCD inhibitor; 4-(2-chlorophenoxy)-N-(3-(methylcarbamoyl)phenyl)piperidine-1-carboxamide; 4-(2-chlorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide; CHEMBL469169; 4-(2-CHLOROPHENOXY)-N-[3-[(METHYLAMINO)CARBONYL]PHENYL]-1-PIPERIDINECARBOXAM. Grades: 95%. CAS No. 1032229-33-6. Molecular formula: C20H22ClN3O3. Mole weight: 387.86. | |
AMPK Signaling Agonist, F17 (4-hydroxy-1-isobutyl-N-(5-methylthiazol-2-yl)-2-oxo-1,2-dihydroquinoline-3-carboxamide) Quick inquiry Where to buy Suppliers range | A cell-permeable 4-hydroxy-2-oxo quinoline carboxamide that acts as an agonist of AMPK signaling. It is shown to reduce fat storage in C. elegans (EC50 ~0.1uM) and reduce the expression level of fat-7 (a C. elegans ortholog of mammalian stearoyl-CoA desaturase-1), through aak-1 (an ortholog for the AMPK-a1 catalytic subunit) and K08F8.2 (a transcription factor) dependent mechanisms. In addition, it markedly reduces the number of lipid droplets in HepG2 human hepatocarcinoma cells at 25uM, and elicits the phosphorylation and inactivation of acetyl coenzyme A carboxylase (ACC, the enzyme that catalyzes the rate-limiting step in de novo fatty acid synthesis). F17-induced ACC phosphorylation can be abrogated by simultaneous treatment with an AMPK inhibitor compound C. Group: Biochemicals. Grades: Highly Purified. CAS No. 280112-24-5. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
CAY10566 Quick inquiry Where to buy Suppliers range | Stearoyl-CoA desaturase (SCD) is an endoplasmic reticulum enzyme that catalyzes the rate-limiting step in the formation of monounsaturated fatty acids (MUFAs), specifically oleate and palmitoleate from stearoyl-CoA and palmitoyl-CoA. CAY10566 is a potent and selective inhibitor with IC50s of 4.5 and 26 nM in mouse and human enzymatic assays, respectively. It also shows excellent cellular activity in blocking the conversion of saturated long-chain fatty acid-CoAs (LCFA-CoAs) to monounsaturated LCFA-CoAs in HepG2 cells. Synonyms: CAY 10566; CAY-10566. Grades: ≥98%. CAS No. 944808-88-2. Molecular formula: C18H17ClFN5O2. Mole weight: 389.8. | |
CP 24,879 hydrochloride Quick inquiry Where to buy Suppliers range | CP 24,879 is an inhibitor of arachidonic acid biosynthesis by inhibition of Δ5/Δ6 desaturase. Synonyms: p-(Isopentyloxy)-aniline; 4-(3-methylbutoxy)-benzenamine monohydrochloride. Grades: ≥98%. CAS No. 10141-51-2. Molecular formula: C11H17NO·HCl. Mole weight: 215.8. | |
D-Eritadenine Quick inquiry Where to buy Suppliers range | D-Eritadenine is an adenosine analog and a potent, reversible inhibitor of S-adenosylhomocysteine hydrolase. Dietary administration of D-eritadenine (50 mg/kg) increases liver microsomal phosphatidylethanolamine concentration and decreases liver microsomal Δ6 desaturase activity and plasma cholesterol levels in rats. Uses: Enzyme inhibitors. Synonyms: (αR,βR)-6-Amino-α,β-dihydroxy-9H-purine-9-butanoic Acid; 4-(6-Amino-9H-purin-9-yl)-4-deoxy-D-erythronic Acid; 4-(6-Aminopurin-9-yl)-4-deoxy-D-erythronic Acid; Lentinacin; Lentysine; 4-(9-Adenyl)-D-erythro-2,3-dihydroxybutyric Acid; Eritadenine; Lentysine; Lentinacin. Grades: ≥95%. CAS No. 23918-98-1. Molecular formula: C9H11N5O4. Mole weight: 253.21. | |
MK-8245 Quick inquiry Where to buy Suppliers range | MK-8245 is a liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy. Synonyms: 4-(2-Bromo-5-fluorophenoxy)-1-[5-(2H-tetrazol-5-yl)-3-isoxazolyl]piperidine; MK-8245; MK8245; MK8245. Grades: 0.98. CAS No. 1030612-90-8. Molecular formula: C17H16BrFN6O4. Mole weight: 467.25. | |
MK-8245 Trifluoroacetate Quick inquiry Where to buy Suppliers range | MK-8245 Trifluoroacetate, a phenoxy piperidine isoxazole derivative, is a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor that has the potential for treatment of dyslipidemia and diabetes. IC50: human SCD1= 1 nM; rat SCD1 and mouse SCD1= 3 nM. Uses: Antidiabetic; antidyslipidemic. Synonyms: MK-8245 Trifluoroacetate; MK 8245 Trifluoroacetate; MK8245 Trifluoroacetate; 2-[5-[3-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-1,2-oxazol-5-yl]tetrazol-2-yl]acetic acid;2,2,2-trifluoroacetic acid; MK-8245 (Trifluoroacetate); 1415559-41-9; 2,2,2-Trifluoroacetic acid compound with 2-(5-(3-(4-(2-bromo-5-fluorophenoxy)piperidin-1-Yl. CAS No. 1415559-41-9. Molecular formula: C19H17BrF4N6O6. Mole weight: 581.28. | |
PluriSln 1 Quick inquiry Where to buy Suppliers range | PluriSln 1 is an inhibitor of stearoyl-CoA desaturase 1 (SCD1). It is useful for eliminating undifferentiated human pluripotent stem cells (hPSCs) from culture by selectively inducing apoptosis in these cells. Additionally, pluriSln 1 induces endoplasmic reticulum stress, reduces protein synthesis, and prevents teratoma formation in immunocompromised mice models. Synonyms: N'-phenylisonicotinohydrazide; N'-phenylpyridine-4-carbohydrazide. Grades: >98%. CAS No. 91396-88-2. Molecular formula: C12H11N3O. Mole weight: 213.24. | |
SC 26196 Quick inquiry Where to buy Suppliers range | SC 26196 is a selective Δ6 desaturase inhibitor (IC50 = 0.2 μM in vitro) that displays >100 fold selectivity over Δ5 and Δ9 desaturases (IC50 >200 μM in vitro). SC 26196 completely inhibits the conversion of linoleic acid to arachidonic acid (AA). It exhibits anti-inflammatory properties in a mouse edema model. Synonyms: α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile; PF-o6341724; FT 0674530; SC 26196; FT0674530; SC26196; FT-0674530; SC-26196. Grades: ≥98% by HPLC. CAS No. 218136-59-5. Molecular formula: C27H29N5. Mole weight: 423.55. | |
SC-26196 Quick inquiry Where to buy Suppliers range | A selective Δ6 desaturase inhibitor (IC50 = 0.2uM in vitro). Displays selectivity over Δ5 and Δ9 desaturases (IC50 values are >200 μM in vitro). It exhibits anti-inflammatory properties in a mouse edema model. Group: Biochemicals. Alternative Names: α , α -Diphenyl-4- [ (3-pyridinyl methyl ene ) amino] -1-piperazinepentane nitrile; SC 26196;PF-o6341724. Grades: Highly Purified. CAS No. 218136-59-5. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
SW203668 trifluoroacetate salt Quick inquiry Where to buy Suppliers range | SW203668 is an irreversible inhibitor of stearoyl-CoA desaturase (IC50 = 54 nM). It is selectively cytotoxic to H2122, H460, HCC44, and HCC95 cell lines. Synonyms: SW203668 TFA; 4-(aminophenylmethyl)-N-(6-methoxy-2-benzothiazolyl)-benzamide trifluoroacetate salt. Grades: ≥98%. CAS No. 2117405-48-6. Molecular formula: C22H19N3O2S·CF3COOH. Mole weight: 503.49. | |
T-3364366 Quick inquiry Where to buy Suppliers range | T-3364366 is a reversible and slow-binding Delta-5 desaturase (D5D) inhibitor. Ki is less than 2.7 nM and a dissociation half-life is more than 2.0 h. D5D is an attractive drug target for inflammatory-related. Uses: Inflammatory-related. Synonyms: T-3364366, T 3364366, T3364366; N-(2-((4-oxo-3-(4-(2,2,2-trifluoroethoxy)phenyl)-3,4-dihydrothieno[3,4-d]pyrimidin-2-yl)thio)ethyl)acetamide. Grades: 98%. CAS No. 1356354-09-0. Molecular formula: C18H16F3N3O3S2. Mole weight: 443.46. |