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| Product | Description | |
|---|---|---|
| 15-cis-phytoene desaturase | This enzyme is involved in carotenoid biosynthesis in plants and cyanobacteria. The enzyme from Synechococcus can also use NAD+ and NADP+ as electron acceptor under anaerobic conditions. The enzyme from Gentiana lutea shows no activity with NAD+ or NADP+. Group: Enzymes. Synonyms: phytoene desaturase (ambiguous); PDS; plant-type phytoene desaturase. Enzyme Commission Number: EC 1.3.5.5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1389; 15-cis-phytoene desaturase; EC 1.3.5.5; phytoene desaturase (ambiguous); PDS; plant-type phytoene desaturase. Cat No: EXWM-1389. |  |
| 1-hydroxy-2-isopentenylcarotenoid 3,4-desaturase | The enzyme, isolated from the archaeon Haloarcula japonica, is involved in the biosynthesis of the C50 carotenoid bacterioruberin. In this pathway it catalyses the desaturation of the C-3,4 double bond in dihydroisopentenyldehydrorhodopin and the desaturation of the C-3',4' double bond in dihydrobisanhydrobacterioruberin. Group: Enzymes. Synonyms: crtD (gene name). Enzyme Commission Number: EC 1.3.99.37. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1437; 1-hydroxy-2-isopentenylcarotenoid 3,4-desaturase; EC 1.3.99.37; crtD (gene name). Cat No: EXWM-1437. | |
| 1-hydroxycarotenoid 3,4-desaturase | The enzymes from Rubrivivax gelatinosus and Rhodobacter sphaeroides prefer the acyclic carotenoids (e.g. 1-hydroxy-1,2-dihydroneurosporene, 1-hydroxy-1,2-dihydrolycopene) as substrates. The conversion rate for the 3,4-desaturation of the monocyclic 1'-hydroxy-1',2'-dihydro-γ-carotene is lower. The enzyme from the marine bacterium strain P99-3 shows high activity with the monocyclic carotenoid 1'-hydroxy-1',2'-dihydro-γ-carotene. The enzyme from Rhodobacter sphaeroides utilizes molecular oxygen as the electron acceptor in vitro. However, oxygen is unlikely to be the natural electron acceptor under anaerobic conditions. Group: Enzymes. Synonyms: CrtD; hydroxyneurosporene desaturase; carotenoid 3,4-dehydrogenase; 1-hydroxy-carotenoid 3,4-dehydrogenase. Enzyme Commission Number: EC 1.3.99.27. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1429; 1-hydroxycarotenoid 3,4-desaturase; EC 1.3.99.27; CrtD; hydroxyneurosporene desaturase; carotenoid 3,4-dehydrogenase; 1-hydroxy-carotenoid 3,4-dehydrogenase. Cat No: EXWM-1429. | |
| 4,4'-diapophytoene desaturase (4,4'-diapolycopene-forming) | The enzyme catalyses four successive dehydrogenations, resulting in production of 4,4'-diapolycopene. While the enzyme from Staphylococcus aureus was only shown to produce 4,4'-diaponeurosporene in vivo, it is able to catalyse the last reaction in vitro. Group: Enzymes. Synonyms: dehydrosqualene desaturase (ambiguous); CrtN (ambiguous); 4,4'-diapophytoene:FAD oxidoreductase (ambiguous); 15-cis-4,4'-diapophytoene:FAD oxidoreductase; 4,4'-diapophytoene desaturase (ambiguous). Enzyme Commission Number: EC 1.3.8.2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1409; 4,4'-diapophytoene desaturase (4,4'-diapolycopene-forming); EC 1.3.8.2; dehydrosqualene desaturase (ambiguous); CrtN (ambiguous); 4,4'-diapophytoene:FAD oxidoreductase (ambiguous); 15-cis-4,4'-diapophytoene:FAD oxidoreductase; 4,4'-diapophytoene desaturase (ambiguous). Cat No: EXWM-1409. | |
| 9,9'-dicis-ζ-carotene desaturase | This enzyme is involved in carotenoid biosynthesis in plants and cyanobacteria. Group: Enzymes. Synonyms: ζ-carotene desaturase; ZDS. Enzyme Commission Number: EC 1.3.5.6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1390; 9,9'-dicis-ζ-carotene desaturase; EC 1.3.5.6; ζ-carotene desaturase; ZDS. Cat No: EXWM-1390. | |
| acyl-[acyl-carrier-protein] 4-desaturase | The enzymes from the plants Coriandrum sativum (coriander) and Hedera helix (English ivy) are involved in biosynthesis of petroselinate [(6Z)-octadec-6-enoate], which is formed by elongation of (4Z)-hexadec-4-enoate. The ivy enzyme can also act on oleoyl-[acyl-carrier protein] and palmitoleoyl-[acyl-carrier protein], generating the corresponding 4,9-diene. Group: Enzymes. Synonyms: Δ4-palmitoyl-[acyl carrier protein] desaturase. Enzyme Commission Number: EC 1.14.19.11. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0973; acyl-[acyl-carrier-protein] 4-desaturase; EC 1.14.19.11; Δ4-palmitoyl-[acyl carrier protein] desaturase. Cat No: EXWM-0973. | |
| acyl-[acyl-carrier-protein] 6-desaturase | The enzyme, characterized from the endosperm of the plant Thunbergia alata (black-eyed Susan vine), introduces a cis double bond at carbon 6 of several saturated acyl-[acp]s. It is most active with palmitoyl-[acp] (16:0), but can also act on myristoyl-[acp] (14:0) and stearoyl-[acp] (18:0). The position of the double bond is determined by its distance from the carboxyl end of the fatty acid. Group: Enzymes. Synonyms: DELTA6 palmitoyl-ACP desaturase; DELTA6 16:0-ACP desaturase. Enzyme Commission Number: EC 1.14.19.26. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0989; acyl-[acyl-carrier-protein] 6-desaturase; EC 1.14.19.26; DELTA6 palmitoyl-ACP desaturase; DELTA6 16:0-ACP desaturase. Cat No: EXWM-0989. | |
| acyl-CoA 11-(E)-desaturase | Involved in sex pheromone synthesis in the Lepidoptera (moths). The enzyme from the moth Spodoptera littoralis prefers 13:0 and 14:0 substrates. The product is formed by the stereospecific removal of the pro-R H at C-11 and the pro-S H at C-12. cf. EC 1.14.19.5, acyl-CoA 11-(Z)-desaturase. Group: Enzymes. Enzyme Commission Number: EC 1.14.19.24. CAS No. 199543-17-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0987; acyl-CoA 11-(E)-desaturase; EC 1.14.19.24; 199543-17-4. Cat No: EXWM-0987. | |
| acyl-CoA 11-(Z)-desaturase | The enzyme introduces a cis double bond at position C-11 of saturated fatty acyl-CoAs. In moths the enzyme participates in the biosynthesis of their sex pheromones. The enzyme from the marine microalga Thalassiosira pseudonana is specific for palmitoyl-CoA (16:0), that from the leafroller moth Choristoneura rosaceana desaturates myristoyl-CoA (14:0), while that from the moth Spodoptera littoralis accepts both substrates. The enzyme contains three histidine boxes that are conserved in all desaturases. It is membrane-bound, and contains a cytochrome b5-like domain at the N-terminus that serves as the electron donor for the active site of the desaturase. Group: Enzymes. Synonyms: Δ11 desaturase; fatty acid Δ11-desaturase; TpDESN; Cro-PG; Δ11 fatty acid desaturase; Z/E11-desaturase; Δ11-palmitoyl-CoA desaturase; acyl-CoA,hydrogen donor:oxygen Δ11. Enzyme Commission Number: EC 1.14.19.5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1013; acyl-CoA 11-(Z)-desaturase; EC 1.14.19.5; Δ11 desaturase; fatty acid Δ11-desaturase; TpDESN; Cro-PG; Δ11 fatty acid desaturase; Z/E11-desaturase; Δ11-palmitoyl-CoA desaturase; acyl-CoA,hydrogen donor:oxygen Δ11-oxidoreductase; Δ11-fatty-acid desaturase. Cat No: EXWM-1013. | |
| acyl-CoA 15-desaturase | The enzyme, characterized from the the plant Sorghum bicolor, is involved in the biosynthesis of sorgoleone, an allelopathic compound produced in root hair cells. The enzyme inserts a cis double bond at carbon 15. When acting on its natural substrate, (9Z,12Z)-hexadeca-9,12-dienoyl-CoA, it produces a product with a terminal double bond. Group: Enzymes. Synonyms: DES3 (gene name). Enzyme Commission Number: EC 1.14.19.13. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0975; acyl-CoA 15-desaturase; EC 1.14.19.13; DES3 (gene name). Cat No: EXWM-0975. | |
| acyl-CoA 5-desaturase | The enzyme, characterized from the plant Anemone leveillei, introduces a cis double bond at carbon 5 of acyl-CoAs that do not contain a double bond at position 8. In vivo it forms non-methylene-interrupted polyunsaturated fatty acids such as sciadonate and juniperonate. When expressed in Arabidopsis thaliana the enzyme could also act on unsaturated substrates such as palmitoyl-CoA. cf. EC 1.14.19.44, acyl-CoA (8-3)-desaturase. Group: Enzymes. Synonyms: acyl-CoA 5-desaturase (non-methylene-interrupted). Enzyme Commission Number: EC 1.14.19.37. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1001; acyl-CoA 5-desaturase; EC 1.14.19.37; acyl-CoA 5-desaturase (non-methylene-interrupted). Cat No: EXWM-1001. | |
| acyl-CoA 6-desaturase | An iron protein. The enzyme introduces a cis double bond at carbon 6 of acyl-CoAs. It is a front-end desaturase, introducing the new double bond between a pre-existing double bond and the carboxyl-end of the fatty acid. The human enzyme has a broad substrate range. It also acts on palmitoyl-CoA, generating sapienoyl-CoA, and on (9Z,12Z,15Z,18Z,21Z)-tetracosa-9,12,15,18,21-pentaenoyl-CoA, converting it to (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosa-6,9,12,15,18,21-hexaenoyl-CoA as part of a pathway that produces docosahexaenoate. The enzyme contains a cytochrome b5 domain that is assumed to act in vivo as the electron donor to the active site of the desaturase. Group: Enzymes. Synonyms: Δ6-desatu. Enzyme Commission Number: EC 1.14.19.3. CAS No. 9082-66-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0993; acyl-CoA 6-desaturase; EC 1.14.19.3; 9082-66-0; Δ6-desaturase; Δ6-fatty acyl-CoA desaturase; Δ6-acyl CoA desaturase; fatty acid Δ6-desaturase; fatty acid 6-desaturase; linoleate desaturase; linoleic desaturase; linoleic acid desaturase; linoleoyl CoA desaturase; linoleoyl-coenzyme A desaturase; long-chain fatty acid Δ6-desaturase; linoleoyl-CoA,hydrogen-donor:oxygen oxidoreductase; linoleoyl-CoA desaturase; FADS2 (gene name). Cat No: EXWM-0993. | |
| acyl-CoA (8-3)-desaturase | The enzyme introduces a cis double bond at carbon 5 of acyl-CoAs that contain a double bond at position 8. The enzymes from algae, mosses, mammals and the protozoan Leishmania major catalyse the desaturation of dihomo-γ-linoleate [(8Z,11Z,14Z)-icosa-8,11,14-trienoate] and (8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoate to generate arachidonate and (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoate, respectively. The enzyme contains a cytochrome b5 domain that acts as the direct electron donor to the desaturase active site and does not require an external cytochrome. cf. EC 1.14.19.37, acyl-CoA 5-desaturase. Group: Enzymes. Synonyms: FADS1 (gene name); acyl-CoA 5-desaturase (methylene-interrupted). Enzyme Commission Number: EC 1.14.19.44. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1009; acyl-CoA (8-3)-desaturase; EC 1.14.19.44; FADS1 (gene name); acyl-CoA 5-desaturase (methylene-interrupted). Cat No: EXWM-1009. | |
| acyl-CoA (9+3)-desaturase | This microsomal enzyme introduces a cis double bond at position 12 of fatty-acyl-CoAs that contain a cis double bond at position 9. When acting on 19:1Δ10 fatty acyl-CoA the enzyme from the pathogenic protozoan Trypanosoma brucei introduces the new double bond at position 13, indicating that the new double bond is introduced three carbons from the existing cis double bond, towards the methyl-end of the fatty acid. Requires cytochrome b5 as the electron donor. Group: Enzymes. Synonyms: oleoyl-CoA 12-desaturase; Δ12 fatty acid desaturase; Δ12(ω6)-desaturase; oleoyl-CoA Δ12 desaturase; Δ12 desaturase; Δ12-desaturase; Δ12-fatty-acid desaturase; acyl-CoA,hydrogen donor:oxygen Δ12-oxidoreductase. Enzyme Commission Number: EC 1.14.19.6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1014; acyl-CoA (9+3)-desaturase; EC 1.14.19.6; oleoyl-CoA 12-desaturase; Δ12 fatty acid desaturase; Δ12(ω6)-desaturase; oleoyl-CoA Δ12 desaturase; Δ12 desaturase; Δ12-desaturase; Δ12-fatty-acid desaturase; acyl-CoA,hydrogen donor:oxygen Δ12-oxidoreductase. Cat No: EXWM-1014. | |
| acyl-lipid (11-3)-desaturase | The enzyme, characterized from the protist Euglena gracilis and the microalga Rebecca salina, introduces a cis double bond at the 8-position in 20-carbon fatty acids that are incorporated into a glycerolipid and have an existing Δ11 desaturation. The enzyme is a front-end desaturase, introducing the new double bond between the pre-existing double bond and the carboxyl-end of the fatty acid. It contains a cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase, and does not require an external cytochrome. Involved in alternative pathways for the biosynthesis of the polyunsaturated fatty acids arachidonate and icosapentaenoate. Group: Enzymes. Synonyms: acyl-lipid 8-desaturase; Δ8 fatty acid desaturase; Δ8-desaturase; Δ8-fatty-acid desaturase; efd1 (gene name); D8Des (gene name); phytosphinganine,hydrogen donor:oxygen Δ. Enzyme Commission Number: EC 1.14.19.4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1004; acyl-lipid (11-3)-desaturase; EC 1.14.19.4; acyl-lipid 8-desaturase; Δ8 fatty acid desaturase; Δ8-desaturase; Δ8-fatty-acid desaturase; efd1 (gene name); D8Des (gene name); phytosphinganine,hydrogen donor:oxygen Δ8-oxidoreductase (incorrect); SLD. Cat No: EXWM-1004. | |
| acyl-lipid (7-3)-desaturase | The enzymes from several algae introduce a cis double bond at the 4-position in 22-carbon polyunsaturated fatty acids that contain a Δ7 double bond. The enzyme from the fresh water alga Chlamydomonas reinhardtii acts on the 16 carbon fatty acid (7Z,10Z,13Z)-hexadeca-7,10,13-trienoate. The enzyme contains an N-terminal cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase, and does not require an external cytochrome. Group: Enzymes. Synonyms: D4Des (gene name); des1 (gene name); CrΔ4FAD (gene name); acyl-lipid 4-desaturase. Enzyme Commission Number: EC 1.14.19.31. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0995; acyl-lipid (7-3)-desaturase; EC 1.14.19.31; D4Des (gene name); des1 (gene name); CrΔ4FAD (gene name); acyl-lipid 4-desaturase. Cat No: EXWM-0995. | |
| acyl-lipid (8-3)-desaturase | The enzyme, which has been characterized from multiple organisms including the moss Physcomitrella patens, the marine microalga Rebecca salina, and the filamentous fungus Mortierella alpina, introduces a cis double bond at the 5-position in 20-carbon polyunsaturated fatty acids incorporated in a glycerolipid that contain a Δ8 double bond. The enzyme contains a cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase, and does not require an external cytochrome. Group: Enzymes. Synonyms: acyl-lipid 5-desaturase; Δ5-fatty-acid desaturase; DES5 (gene name); D5des (gene name); FADS1. Enzyme Commission Number: EC 1.14.19.30. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0994; acyl-lipid (8-3)-desaturase; EC 1.14.19.30; acyl-lipid 5-desaturase; Δ5-fatty-acid desaturase; DES5 (gene name); D5des (gene name); FADS1. Cat No: EXWM-0994. | |
| acyl-lipid (9-3)-desaturase | The enzyme, characterized from the moss Physcomitrella patens and the plant Borago officinalis (borage), introduces a cis double bond at carbon 6 of several acyl-lipids that contain an existing Δ9 cis double bond. The enzyme contains a cytochrome b5 domain that acts as the electron donor for the active site of the desaturase. Group: Enzymes. Synonyms: acyl-lipid 6-desaturase; Δ6-desaturase; DES6 (gene name). Enzyme Commission Number: EC 1.14.19.47. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1012; acyl-lipid (9-3)-desaturase; EC 1.14.19.47; acyl-lipid 6-desaturase; Δ6-desaturase; DES6 (gene name). Cat No: EXWM-1012. | |
| acyl-lipid (9+3)-(E)-desaturase | The enzymes from the plants Dimorphotheca sinuata (African daisy) and Vernicia fordii (tung oil tree) insert a trans double bond in position C-12 of oleate and palmitoleate incorporated into glycerolipids. The enzyme introduces the new double bond at a position three carbons away from an existing double bond at position 9, towards the methyl end of the fatty acid. The enzyme from tung oil tree also possesses the activity of EC 1.14.19.33, Δ12 acyl-lipid conjugase. Group: Enzymes. Synonyms: acyl-lipid 12-(E)-desaturase; DsFAD2-1; FADX. Enzyme Commission Number: EC 1.14.19.34. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0998; acyl-lipid (9+3)-(E)-desaturase; EC 1.14.19.34; acyl-lipid 12-(E)-desaturase; DsFAD2-1; FADX. Cat No: EXWM-0998. | |
| acyl-lipid (n+3)-(Z)-desaturase (ferredoxin) | This plastidial enzyme is able to insert a cis double bond in monounsaturated fatty acids incorporated into glycerolipids. The enzyme introduces the new bond at a position 3 carbons away from the existing double bond, towards the methyl end of the fatty acid. The native substrates are oleoyl (18:1 Δ9) and (Z)-hexadec-7-enoyl (16:1 Δ7) groups attached to either position of the glycerol backbone in glycerolipids, resulting in the introduction of the second double bond at positions 12 and 10, respectively This prompted the suggestion that this is an ω6 desaturase. However, when acting on palmitoleoyl groups(16:1 Δ9), the enzyme introduces the second double bond at position 12 (ω4), indicating it is an (n+3) desaturase. cf. EC 1.14.19.34, acyl-lipid (9+3)-(E)-desaturase. Group: Enzymes. Synonyms: acyl-. Enzyme Commission Number: EC 1.14.19.23. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0986; acyl-lipid (n+3)-(Z)-desaturase (ferredoxin); EC 1.14.19.23; acyl-lipid ω6-desaturase (ferredoxin); oleate desaturase (ambiguous); linoleate synthase (ambiguous); oleoyl-CoA desaturase (ambiguous); oleoylphosphatidylcholine desaturase (ambiguous); phosphatidylcholine desaturase (ambiguous); FAD6 (gene name). Cat No: EXWM-0986. | |
| acyl-lipid ω-3 desaturase (cytochrome b5) | This microsomal enzyme introduces a cis double bond three carbons away from the methyl end of a fatty acid incorporated into a glycerolipid. The distance from the carboxylic acid end of the molecule does not have an effect. The plant enzyme acts on carbon 15 of linoleoyl groups incorporated into both the sn-1 and sn-2 positions of the glycerol backbone of phosphatidylcholine and other phospholipids, converting them into α-linolenoyl groups. The enzyme from the fungus Mortierella alpina acts on γ-linolenoyl and arachidonoyl groups, converting them into stearidonoyl and icosapentaenoyl groups, respectively. cf. EC 1.14.19.35, acyl-lipid ω-3 desaturase (ferredoxin). Group: Enzymes. Synonyms: FAD3. Enzyme Commission Number: EC 1.14.19.25. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0988; acyl-lipid ω-3 desaturase (cytochrome b5); EC 1.14.19.25; FAD3. Cat No: EXWM-0988. | |
| acyl-lipid ω-6 desaturase (cytochrome b5) | This microsomal enzyme introduces a cis double bond in fatty acids attached to lipid molecules at a location 6 carbons away from the methyl end of the fatty acid. The distance from the carboxylic acid end of the molecule does not affect the location of the new double bond. The most common substrates are oleoyl groups attached to either the sn-1 or sn-2 position of the glycerol backbone in phosphatidylcholine. cf. EC 1.14.19.23, acyl-lipid ω-6 desaturase (ferredoxin). Group: Enzymes. Synonyms: oleate desaturase (ambiguous); linoleate synthase (ambiguous); oleoyl-CoA desaturase (incorrect); oleoylphosphatidylcholine desaturase (ambiguous); phosphatidylcholine desaturase (ambiguous); n-6 desaturase (ambiguous); FAD2 (gene name). Enzyme Commission Number: EC 1.14.19.22. CAS No. 72536-70-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0985; acyl-lipid ω-6 desaturase (cytochrome b5); EC 1.14.19.22; 72536-70-0; oleate desaturase (ambiguous); linoleate synthase (ambiguous); oleoyl-CoA desaturase (incorrect); oleoylphosphatidylcholine desaturase (ambiguous); phosphatidylcholine desaturase (ambiguous); n-6 desaturase (ambiguous); FAD2 (gene name). Cat No: EXWM-0985. | |
| acyl-lipid ω-(9-4) desaturase | The enzyme, characterized from the green alga Chlamydomonas reinhardtii, is a front-end desaturase that introduces a cis double bond in ω9 unsaturated C18 or C20 fatty acids incorporated into lipids, at a position 4 carbon atoms from the existing ω9 bond, towards the carboxy end of the fatty acid (at the ω13 position). When acting on 20:2Δ(11,14) and 20:3Δ(11,14,17) substrates it introduces the new double bond between carbons 7 and 8. The enzyme contains a cytochrome b5 domain that acts as the direct electron donor for the active site of the desaturase. Group: Enzymes. Synonyms: acyl-lipid ω-13 desaturase; acyl-lipid 7-desaturase (ambiguous). Enzyme Commission Number: EC 1.14.19.12. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0974; acyl-lipid ω-(9-4) desaturase; EC 1.14.19.12; acyl-lipid ω-13 desaturase; acyl-lipid 7-desaturase (ambiguous). Cat No: EXWM-0974. | |
| all-trans-ζ-carotene desaturase | This enzyme is involved in carotenoid biosynthesis. Group: Enzymes. Synonyms: Crtlb; phytoene desaturase (ambiguous); 2-step phytoene desaturase (ambiguous); two-step phytoene desaturase (ambiguous); CrtI (ambiguous). Enzyme Commission Number: EC 1.3.99.26. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1428; all-trans-ζ-carotene desaturase; EC 1.3.99.26; Crtlb; phytoene desaturase (ambiguous); 2-step phytoene desaturase (ambiguous); two-step phytoene desaturase (ambiguous); CrtI (ambiguous). Cat No: EXWM-1428. | |
| cholesterol 7-desaturase | The enzyme, characterized from several organisms including the worm Caenorhabditis elegans, the fly Drosophila melanogaster, and the ciliate Tetrahymena thermophila, is a Rieske oxygenase. In insects it participates in the the biosythesis of ecdysteroid hormones. The electrons are transferred from NAD(P)H via an electron transfer chain likely to include ferredoxin reductase and ferredoxin. The enzyme differs from regular desaturases, such as EC 1.14.19.20, 7-sterol 5(6)-desaturase, which are cytochrome b5-dependent and contain the three His-boxes that are typical to most desaturases. Group: Enzymes. Synonyms: nvd (gene name); daf-36 (gene name). Enzyme Commission Number: EC 1.14.19.21. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0984; cholesterol 7-desaturase; EC 1.14.19.21; nvd (gene name); daf-36 (gene name). Cat No: EXWM-0984. | |
| Δ7-sterol 5(6)-desaturase | This enzyme, found in eukaryotic organisms, catalyses the introduction of a double bond between the C5 and C6 carbons of the B ring of Δ7-sterols, to yield the corresponding Δ5,7-sterols. The enzymes from yeast, plants and vertebrates act on avenasterol, episterol, and lathosterol, respectively. The enzyme is located at the endoplasmic reticulum and is membrane bound. Group: Enzymes. Synonyms: lathosterol oxidase; Δ7-sterol Δ5-dehydrogenase; Δ7-sterol 5-desaturase; Δ7-sterol-C5(6)-desaturase; 5-DES; SC5DL (gene name); ERG3 (gene name). Enzyme Commission Number: EC 1.14.19.20. CAS No. 37255-37-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0983; Δ7-sterol 5(6)-desaturase; EC 1.14.19.20; 37255-37-1; lathosterol oxidase; Δ7-sterol Δ5-dehydrogenase; Δ7-sterol 5-desaturase; Δ7-sterol-C5(6)-desaturase; 5-DES; SC5DL (gene name); ERG3 (gene name). Cat No: EXWM-0983. | |
| icosanoyl-CoA 5-desaturase | The enzyme, characterized from the plant Limnanthes douglasii (meadowfoam), is involved in the biosynthesis of (5Z)-icos-5-enoate, an unusual monounsaturated fatty acid that makes up to 60% of the total fatty acids in Limnanthes sp. seed oil. The enzyme only acts on saturated fatty acids. Group: Enzymes. Synonyms: acyl-CoA Δ5-desaturase (ambiguous). Enzyme Commission Number: EC 1.14.19.10. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0972; icosanoyl-CoA 5-desaturase; EC 1.14.19.10; acyl-CoA Δ5-desaturase (ambiguous). Cat No: EXWM-0972. | |
| palmitoyl-CoA 14-(E/Z)-desaturase | The enzyme, found in the moth Ostrinia furnacalis (Asian corn borer), produces a mixture of (E)- and (Z)- isomers. The products are subsequently truncated by partial β-oxidation to a blend of 12(E/Z)-tetradec-12-enoyl-CoA, which are converted to the species-specific sex pheromones (E)- and (Z)-tetradec-12-enoyl acetates. Group: Enzymes. Enzyme Commission Number: EC 1.14.19.32. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0996; palmitoyl-CoA 14-(E/Z)-desaturase; EC 1.14.19.32. Cat No: EXWM-0996. | |
| palmitoyl-[glycerolipid] 3-(E)-desaturase | The enzyme introduces an unusual trans double bond at carbon 3 of a palmitoyl group attached to the sn-2 position of glycerolipids. The enzyme from the plant Arabidopsis thaliana is specific for palmitate in phosphatidylglycerol. The enzyme from tobacco can also accept oleate and α-linolenate if present at the sn-2 position of phosphatidylglycerol. Group: Enzymes. Synonyms: FAD4. Enzyme Commission Number: EC 1.14.19.43. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1008; palmitoyl-[glycerolipid] 3-(E)-desaturase; EC 1.14.19.43; FAD4. Cat No: EXWM-1008. | |
| palmitoyl-[glycerolipid] 7-desaturase | The enzyme introduces a cis double bond at carbon 7 of a palmitoyl group attached to the sn-2 position of glycerolipids. The enzyme from the plant Arabidopsis thaliana is specific for palmitate in monogalactosyldiacylglycerol. Group: Enzymes. Synonyms: FAD5. Enzyme Commission Number: EC 1.14.19.42. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1007; palmitoyl-[glycerolipid] 7-desaturase; EC 1.14.19.42; FAD5. Cat No: EXWM-1007. | |
| phytoene desaturase (3,4-didehydrolycopene-forming) | This enzyme is involved in carotenoid biosynthesis and catalyses up to five desaturation steps (cf. EC 1.3.99.28 [phytoene desaturase (neurosporene-forming)], EC 1.3.99.29 [phytoene desaturase (ζ-carotene-forming)] and EC 1.3.99.31 [phytoene desaturase (lycopene-forming)]). Group: Enzymes. Synonyms: 5-step phytoene desaturase; five-step phytoene desaturase; phytoene desaturase (ambiguous); Al-1. Enzyme Commission Number: EC 1.3.99.30. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1432; phytoene desaturase (3,4-didehydrolycopene-forming); EC 1.3.99.30; 5-step phytoene desaturase; five-step phytoene desaturase; phytoene desaturase (ambiguous); Al-1. Cat No: EXWM-1432. | |
| phytoene desaturase (lycopene-forming) | Requires FAD. The enzyme is involved in carotenoid biosynthesis and catalyses up to four desaturation steps (cf. EC 1.3.99.28 [phytoene desaturase (neurosporene-forming)], EC 1.3.99.29 [phytoene desaturase (ζ-carotene-forming)] and EC 1.3.99.30 [phytoene desaturase (3,4-didehydrolycopene-forming)]). Group: Enzymes. Synonyms: 4-step phytoene desaturase; four-step phytoene desaturase; phytoene desaturase (ambiguous); CrtI (ambiguous). Enzyme Commission Number: EC 1.3.99.31. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1433; phytoene desaturase (lycopene-forming); EC 1.3.99.31; 4-step phytoene desaturase; four-step phytoene desaturase; phytoene desaturase (ambiguous); CrtI (ambiguous). Cat No: EXWM-1433. | |
| phytoene desaturase (neurosporene-forming) | This enzyme is involved in carotenoid biosynthesis and catalyses up to three desaturation steps (cf. EC 1.3.99.29 [phytoene desaturase (ζ-carotene-forming)], EC 1.3.99.30 [phytoene desaturase (3,4-didehydrolycopene-forming)], EC 1.3.99.31 [phytoene desaturase (lycopene-forming)]). The enzyme is activated by FAD. NAD+, NADP+ or ATP show no activating effect. Group: Enzymes. Synonyms: 3-step phytoene desaturase; three-step phytoene desaturase; phytoene desaturase (ambiguous); CrtI (ambiguous). Enzyme Commission Number: EC 1.3.99.28. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1430; phytoene desaturase (neurosporene-forming); EC 1.3.99.28; 3-step phytoene desaturase; three-step phytoene desaturase; phytoene desaturase (ambiguous); CrtI (ambiguous). Cat No: EXWM-1430. | |
| phytoene desaturase (ζ-carotene-forming) | The enzyme is involved in carotenoid biosynthesis and catalyses up to two desaturation steps (cf. EC 1.3.99.28 [phytoene desaturase (neurosporene-forming)], EC 1.3.99.30 [phytoene desaturase (3,4-didehydrolycopene-forming)] and EC 1.3.99.31 [phytoene desaturase (lycopene-forming)]). Group: Enzymes. Synonyms: CrtIa; 2-step phytoene desaturase (ambiguous); two-step phytoene desaturase (ambiguous). Enzyme Commission Number: EC 1.3.99.29. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1431; phytoene desaturase (ζ-carotene-forming); EC 1.3.99.29; CrtIa; 2-step phytoene desaturase (ambiguous); two-step phytoene desaturase (ambiguous). Cat No: EXWM-1431. | |
| plasmanylethanolamine desaturase | Requires NADPH or NADH. May involve cytochrome b5. Requires Mg2+ and ATP. Group: Enzymes. Synonyms: alkylacylglycerophosphoethanolamine desaturase; alkylacylglycero-phosphorylethanolamine dehydrogenase; dehydrogenase, alkyl-acylglycerophosphorylethanolamine; 1-O-alkyl-2-acyl-sn-glycero-3-phosphorylethanolamine desaturase; 1-O-alkyl 2-acyl-sn-glycero-3-phosphorylethanolamine desaturase. Enzyme Commission Number: EC 1.14.99.19. CAS No. 39391-13-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1036; plasmanylethanolamine desaturase; EC 1.14.99.19; 39391-13-4; alkylacylglycerophosphoethanolamine desaturase; alkylacylglycero-phosphorylethanolamine dehydrogenase; dehydrogenase, alkyl-acylglycerophosphorylethanolamine; 1-O-alkyl-2-acyl-sn-glycero-3-phosphorylethanolamine desaturase; 1-O-alkyl 2-acyl-sn-glycero-3-phosphorylethanolamine desaturase. Cat No: EXWM-1036. | |
| sn-1 acyl-lipid ω-3 desaturase (ferredoxin) | The enzyme, characterized from cyanobacteria, introduces a cis double bond at carbon 15 of linoleoyl and γ-linolenoyl groups attached to the sn-1 position of glycerolipids. The enzyme is an ω desaturase, and determines the location of the double bond by counting three carbons from the methyl end of the fatty acid. It is nonspecific with respect to the polar head group of the glycerolipid. cf. EC 1.14.19.35, sn-2 acyl-lipid ω-3 desaturase (ferredoxin). Group: Enzymes. Synonyms: desB (gene name). Enzyme Commission Number: EC 1.14.19.36. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1000; sn-1 acyl-lipid ω-3 desaturase (ferredoxin); EC 1.14.19.36; desB (gene name). Cat No: EXWM-1000. | |
| sn-1 linoleoyl-lipid 6-desaturase | The enzyme, characterized from cyanobacteria, introduces a cis double bond at carbon 6 of linoleoyl groups (18:2) attached to the sn-1 position of glycerolipids. The enzyme is a front-end desaturase, introducing the new double bond between a pre-existing double bond and the carboxyl-end of the fatty acid. It is nonspecific with respect to the polar head group of the glycerolipid. Group: Enzymes. Synonyms: desD (gene name). Enzyme Commission Number: EC 1.14.19.46. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1011; sn-1 linoleoyl-lipid 6-desaturase; EC 1.14.19.46; desD (gene name). Cat No: EXWM-1011. | |
| sn-1 oleoyl-lipid 12-desaturase | The enzyme, characterized from cyanobacteria, introduces a cis double bond at carbon 12 of oleoyl groups (18:1) attached to the sn-1 position of glycerolipids. The enzyme is a methyl-end desaturase, introducing the new double bond between a pre-existing double bond and the methyl-end of the fatty acid. It is nonspecific with respect to the polar head group of the glycerolipid. Group: Enzymes. Synonyms: desA (gene name). Enzyme Commission Number: EC 1.14.19.45. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1010; sn-1 oleoyl-lipid 12-desaturase; EC 1.14.19.45; desA (gene name). Cat No: EXWM-1010. | |
| sn-1 stearoyl-lipid 9-desaturase | The enzyme, characterized from cyanobacteria, introduces a cis double bond at carbon 9 of stearoyl groups (18:0) attached to the sn-1 position of glycerolipids. The enzyme is nonspecific with respect to the polar head group of the glycerolipid. Group: Enzymes. Synonyms: desC (gene name). Enzyme Commission Number: EC 1.14.19.28. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0991; sn-1 stearoyl-lipid 9-desaturase; EC 1.14.19.28; desC (gene name). Cat No: EXWM-0991. | |
| sn-2 acyl-lipid ω-3 desaturase (ferredoxin) | This plastidial enzyme desaturates 16:2 fatty acids attached to the sn-2 position of glycerolipids to 16:3 fatty acids, and converts18:2 to 18:3 in both the sn-1 and sn-2 positions. It acts on all 16:2- or 18:2-containing chloroplast membrane lipids, including phosphatidylglycerol, monogalactosyldiacylglycerol, digalactosyldiaclyglycerol, and sulfoquinovosyldiacylglycerol. The enzyme introduces a cis double bond at a location 3 carbons away from the methyl end of the fatty acid. The distance from the carboxylic acid end of the molecule does not affect the location of the new double bond. cf. EC 1.14.19.25, acyl-lipid ω-3 desaturase (cytochrome b5) and EC 1.14.19.36, sn-1 acyl-lipid ω-3 desaturase (ferredoxin). Group: Enzymes. Synonyms: FAD7; FAD8. Enzyme Commission Number: EC 1.14.19.35. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0999; sn-2 acyl-lipid ω-3 desaturase (ferredoxin); EC 1.14.19.35; FAD7; FAD8. Cat No: EXWM-0999. | |
| sn-2 palmitoyl-lipid 9-desaturase | The enzyme, characterized from the cyanobacterium Nostoc sp. 36, introduces a cis double bond at carbon 9 of palmitoyl groups (16:0) attached to the sn-2 position of glycerolipids. Group: Enzymes. Synonyms: DesC2. Enzyme Commission Number: EC 1.14.19.27. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0990; sn-2 palmitoyl-lipid 9-desaturase; EC 1.14.19.27; DesC2. Cat No: EXWM-0990. | |
| sphingolipid 10-desaturase | The enzyme, characterized from the marine diatom Thalassiosira pseudonana, produces an all-trans product. Similar triunsaturated sphingoid bases are found in some marine invertebrates. The enzyme determines the position of the double bond by its distance from the alcohol end of the sphingoid base, and contains a cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase. Group: Enzymes. Synonyms: desA (gene name). Enzyme Commission Number: EC 1.14.19.19. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0981; sphingolipid 10-desaturase; EC 1.14.19.19; desA (gene name). Cat No: EXWM-0981. | |
| sphingolipid 4-desaturase | The enzyme, which has been characterized from plants, fungi, and mammals, generates a trans double bond at position 4 of sphinganine bases in sphingolipids. The preferred substrate is dihydroceramide, but the enzyme is also active with dihydroglucosylceramide. Unlike EC 1.14.19.29, sphingolipid 8-desaturase, this enzyme does not contain an integral cytochrome b5 domain and requires an external cytochrome b5. The product serves as an important signalling molecules in mammals and is required for spermatide differentiation. Group: Enzymes. Synonyms: dehydroceramide desaturase. Enzyme Commission Number: EC 1.14.19.17. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0979; sphingolipid 4-desaturase; EC 1.14.19.17; dehydroceramide desaturase. Cat No: EXWM-0979. | |
| sphingolipid 8-(E)-desaturase | The enzyme, characterized from the yeasts Kluyveromyces lactis and Candida albicans and from the diatom Thalassiosira pseudonana, introduces a trans double bond at the 8-position of sphingoid bases in sphingolipids. The enzyme determines the position of the double bond by its distance from the alcohol end of the sphingoid base, and contains a cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase. The homologous enzymes from higher plants, EC 1.14.19.29, sphingolipid 8-(E/Z)-desaturase, act on phytosphinganine (4-hydroxysphinganine) and produces a mixture of trans and cis isomers. Group: Enzymes. Synonyms: 8-sphingolipid desaturase (ambiguous); 8 fatty acid desaturase (ambiguous); DELTA8-sphingolipid desaturase (ambiguous). Enzyme Commission Number: EC 1.14.19.18. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0980; sphingolipid 8-(E)-desaturase; EC 1.14.19.18; 8-sphingolipid desaturase (ambiguous); 8 fatty acid desaturase (ambiguous); DELTA8-sphingolipid desaturase (ambiguous). Cat No: EXWM-0980. | |
| sphingolipid 8-(E/Z)-desaturase | The enzymes from higher plants convert sphinganine, 4E-sphing-4-enine and phytosphinganine into E/Z-mixtures of Δ8-desaturated products displaying different proportions of geometrical isomers depending on plant species. The nature of the actual desaturase substrate has not yet been studied experimentally. The enzymes contain an N-terminal cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase. The homologous enzymes from some yeasts and diatoms, EC 1.14.19.18, sphingolipid 8-(E)-desaturase, act on sphing-4-enine ceramides and produce only the trans isomer. Group: Enzymes. Synonyms: 8-sphingolipid desaturase (ambiguous); 8 fatty acid desaturase (ambiguous); DELTA8-sphingolipid desaturase (ambiguous). Enzyme Commission Number: EC 1.14.19.29. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0992; sphingolipid 8-(E/Z)-desaturase; EC 1.14.19.29; 8-sphingolipid desaturase (ambiguous); 8 fatty acid desaturase (ambiguous); DELTA8-sphingolipid desaturase (ambiguous). Cat No: EXWM-0992. | |
| stearoyl-[acyl-carrier-protein] 9-desaturase | The enzyme is found in the lumen of plastids, where de novo biosynthesis of fatty acids occurs, and acts on freshly synthesized saturated fatty acids that are still linked to acyl-carrier protein. The enzyme determines the position of the double bond by its distance from the carboxylic acid end of the fatty acid. It also acts on palmitoyl-[acyl-carrier-protein]. Group: Enzymes. Synonyms: stearyl acyl carrier protein desaturase; stearyl-ACP desaturase; acyl-[acyl-carrier-protein] desaturase; acyl-[acyl-carrier protein],hydrogen-donor:oxygen oxidoreductase. Enzyme Commission Number: EC 1.14.19.2. CAS No. 37256-86-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0982; stearoyl-[acyl-carrier-protein] 9-desaturase; EC 1.14.19.2; 37256-86-3; stearyl acyl carrier protein desaturase; stearyl-ACP desaturase; acyl-[acyl-carrier-protein] desaturase; acyl-[acyl-carrier protein],hydrogen-donor:oxygen oxidoreductase. Cat No: EXWM-0982. | |
| stearoyl-CoA 9-desaturase | An iron protein. The rat liver enzyme is an enzyme system involving cytochrome b5 and EC 1.6.2.2, cytochrome-b5 reductase. The ferricytochrome b5 produced is reduced by NADH and cytochrome-b5 reductase (EC 1.6.2.2). Group: Enzymes. Synonyms: Δ9-desaturase; acyl-CoA desaturase; fatty acid desaturase; stearoyl-CoA, hydrogen-donor:oxygen oxidoreductase. Enzyme Commission Number: EC 1.14.19.1. CAS No. 9014-34-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0971; stearoyl-CoA 9-desaturase; EC 1.14.19.1; 9014-34-0; Δ9-desaturase; acyl-CoA desaturase; fatty acid desaturase; stearoyl-CoA, hydrogen-donor:oxygen oxidoreductase. Cat No: EXWM-0971. | |
| Stearoyl CoA Desaturase 1 Inhibitor (4- (2-Chlorophenoxy) -N- (3- (3-methylcarbamoyl) phenyl) piperidine-1-carboxamide, SCD1 Inhibitor) | Cell-permeable. A potent and selective inhibitor of SCD1(stearoyl-CoA desaturase 1) (In vitro: IC50 = 37nM for hSCD1, < 4nM for mSCD1). Also exhibited in vivo efficacy with dose-dependent desaturation index lowering effect. SCD1 inhibition resulted in alterationsin macrophage membrane lipid composition and marked hypersensitivity to toll-like receptor 4 agonists. Group: Biochemicals. Alternative Names: 4- (2-Chlorophenoxy) -N- (3- (3-methylcarbamoyl) phenyl) piperidine-1-carboxamide. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| Stearoyl-CoA Desaturase 1 Inhibitor, MF-438 (2-methyl-5- (6- (4- (2- (trifluoromethyl) phenoxy) piperidin-1-yl) pyridazin-3-yl) -1, 3, 4-thiadiazole) | A cell-permeable, thiadiazole-pyridazine compound that acts as an inhibitor of Stearoyl-CoA Desaturase 1 (SCD1) with an IC50 of 2.3nM. In vivo, it exhibits an ED50 of 1-3mg/kg, p.o., in mouse liver PD assays. Group: Biochemicals. Grades: Highly Purified. CAS No. 921605-87-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| sterol 22-desaturase | A heme-thiolate protein (P450). The enzyme, found in yeast and plants, catalyses the introduction of a double bond between the C-22 and C-23 carbons of certain sterols. In yeast the enzyme acts on ergosta-5,7,24(28)-trien-3β-ol, a step in the biosynthesis of ergosterol. The enzyme from the plant Arabidopsis thaliana acts on sitosterol and 24-epi-campesterol, producing stigmasterol and brassicasterol, respectively. Group: Enzymes. Synonyms: ERG5 (gene name); CYP710A (gene name). Enzyme Commission Number: EC 1.14.19.41. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1006; sterol 22-desaturase; EC 1.14.19.41; ERG5 (gene name); CYP710A (gene name). Cat No: EXWM-1006. | |
| 10(E),12(Z)-Conjugated linoleic acid | Conjugated linoleic acid (CLA) refers to a family of 8 geometric isomers of linoleic acid in which the two double bonds are contiguous. (The predominant form of linoleic acid in nature, 18:ω6, has double bonds at 9 and 12, interrupted by a methylene carbon.) CLA is found in both meat and dairy products, but it is not found to any significant degree in plants. Various antioxidant and antitumor activities have been attributed to CLA or its downstream metabolites. Reported health benefits of dietary supplementation with CLA have been attributed variously to competitive inhibition of Δ6-desaturase and/or PPARγ activation. Synonyms: 10E,12Z-CLA; 10E,12Z-octadecadienoic acid. Grades: ≥98%. CAS No. 2420-56-6. Molecular formula: C18H32O2. Mole weight: 280.5. |  |
| (11Z)-hexadec-11-enoyl-CoA conjugase | The enzyme, characterized from the silk moth Bombyx mori, catalyses a step in the pathway for the biosynthesis of bombykol, a sex pheromone produced by the moth. The enzyme converts a single cis double bond at position 11 of (11Z)-hexadec-11-enoyl-CoA into conjugated 10 trans and 12 cis double bonds. Prior to catalysing this reaction, the enzyme catalyses the introduction of the cis bond in position 11 (cf. EC 1.14.19.5, acyl-CoA 11-desaturase). Group: Enzymes. Synonyms: Bmpgdesat1 (gene name). Enzyme Commission Number: EC 1.14.19.15. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0977; (11Z)-hexadec-11-enoyl-CoA conjugase; EC 1.14.19.15; Bmpgdesat1 (gene name). Cat No: EXWM-0977. | |
| 1-(2-Chloro-6-hydroxyphenyl)ethanone | 1-(2-Chloro-6-hydroxyphenyl)ethanone is used for synthesis and structure-activity relationship of novel spiropiperidine-based stearoyl-CoA desaturase-1 inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 55736-04-4. Pack Sizes: 50mg, 100mg. Molecular Formula: C8H7ClO2, Molecular Weight: 170.59. US Biological Life Sciences. | Worldwide |
| 1-Iodo-3,5-bis(trifluoromethyl)-benzene | 1-Iodo-3,5-bis(trifluoromethyl)-benzene is a useful synthetic intermediate. It can be used to prepare stearoyl-CoA desaturase-1 inhibitors and cholesteryl ester transfer protein inhibitors. It is also used to synthesize Flupropadine (F500750), a sub-acute rodenticide. Group: Biochemicals. Grades: Highly Purified. CAS No. 328-73-4. Pack Sizes: 10g, 25g. Molecular Formula: C8H3F6I, Molecular Weight: 340. US Biological Life Sciences. | Worldwide |
| 2-Amino-5-(trifluoromethyl)-4-thiazolecarboxylic Acid | 2-Amino-5-(trifluoromethyl)-4-thiazolecarboxylic Acid is a derivative of 2-Aamino-4-thiazolecarboxylic Acid Ethyl Ester (E678465), a chemical reagent used in the preparation fo SAR thiazolamino arylaminopyrimidines as anaplastic lymphoma kinase inhibitors. As well as in the synthesis of 4-bicyclick piperadine derivatives as potent stearoyl-CoA desaturase (SCD1) inhibitors in the treatment of cancer. Group: Biochemicals. Grades: Highly Purified. CAS No. 1086380-23-5. Pack Sizes: 10mg, 100mg. Molecular Formula: C5H3F3N2O2S, Molecular Weight: 212.15. US Biological Life Sciences. | Worldwide |
| (2R)-Tetrahydro-2-furanmethanamine Hydrochloride | (2R)-Tetrahydro-2-furanmethanamine is a stereoisomer of Tetrahydro-2-furanmethanamine (T293545) which is used in the synthesis of novel topoisomerase I targeting anti-cancer agents with mild to potent cytotoxic activity. Tetrahydro-2-furanmethanamine (T293545) is also used in the discovery and synthesis of orally bioavailable stearoyl-CoA desaturase 1 inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 7175-80-6. Pack Sizes: 1g, 10g. Molecular Formula: C5H11NO HCl. US Biological Life Sciences. | Worldwide |
| (2S)-Tetrahydro-2-furanmethanamine Hydrochloride | (2S)-Tetrahydro-2-furanmethanamine Hydrochloride is a stereoisomeric salt of Tetrahydro-2-furanmethanamine (T293545) which is used in the synthesis of novel topoisomerase I targeting anti-cancer agents with mild to potent cytotoxic activity. Tetrahydro-2-furanmethanamine (T293545) is also used in the discovery and synthesis of orally bioavailable stearoyl-CoA desaturase 1 inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 21801-94-5. Pack Sizes: 100mg, 500mg. Molecular Formula: C5H12ClNO. US Biological Life Sciences. | Worldwide |
| 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase | The enzyme, characterized from yeast and mammals, catalyses the hydroxylation of carbon 2 of long- or very-long-chain fatty acids attached to (4R)-4-hydroxysphinganine during de novo ceramide synthesis. The enzymes from yeast and from mammals contain an N-terminal cytochrome b5 domain that acts as the direct electron donor to the desaturase active site. The newly introduced 2-hydroxyl group has R-configuration. cf. EC 1.14.18.7, dihydroceramide fatty acyl 2-hydroxylase. Group: Enzymes. Synonyms: FA2H (gene name); SCS7 (gene name). Enzyme Commission Number: EC 1.14.18.6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0968; 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase; EC 1.14.18.6; FA2H (gene name); SCS7 (gene name). Cat No: EXWM-0968. | |
| 8,11-Eicosadiynoic acid | 8,11-Eicosadiynoic acid is an acetylenic fatty acid which inhibits arachidonic acid metabolism at several unrelated stages. 8,11-Eicosadiynoic acid inhibits the enzymes, arachidonoyl synthase, acyl-CoA synthase, Δ-5-desaturase, COX, and also arachidonic acid uptake by platelets. Synonyms: EDYA; Eicosa-8,11-diynoic acid. Grades: ≥95%. CAS No. 82073-91-4. Molecular formula: C20H32O2. Mole weight: 304.5. | |
| A939572 | A939572 is a effective and highly selective cell-permeable inhibitor of SCD1(stearoyl-CoA desaturase 1) which could be mediated by hormonal and dietary actions. It is under early phase clinical trials for its potential effect in obesity and diabetes. IC50. Uses: A939572 is a effective and highly selective cell-permeable inhibitor of scd1(stearoyl-coa desaturase 1) which could be mediated by hormonal and dietary actions. Synonyms: A939572; A-939572; A 939572. SCD inhibitor; 4-(2-chlorophenoxy)-N-(3-(methylcarbamoyl)phenyl)piperidine-1-carboxamide; 4-(2-chlorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide; CHEMBL469169; 4-(2-CHLOROPHENOXY)-N-[3-[(METHYLAMINO)CARBONYL]PHENYL]-1-PIPERIDINECARBOXAM. Grades: 95%. CAS No. 1032229-33-6. Molecular formula: C20H22ClN3O3. Mole weight: 387.86. | |
| acyl-lipid Δ6-acetylenase | The enzyme, characterized from the moss Ceratodon purpureus, converts the double bond at position 6 of γ-linolenate and stearidonate into a triple bond. The product of the latter, dicranin, is the main fatty acid found in C. purpureus. The enzyme contains a cytochrome b5 domain that acts as the direct electron donor to the desaturase active site. The enzyme also has the activity of EC 1.14.19.47, acyl-lipid (9-3)-desaturase. Group: Enzymes. Enzyme Commission Number: EC 1.14.19.38. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1002; acyl-lipid Δ6-acetylenase; EC 1.14.19.38. Cat No: EXWM-1002. | |
| AMPK Signaling Agonist, F17 (4-hydroxy-1-isobutyl-N-(5-methylthiazol-2-yl)-2-oxo-1,2-dihydroquinoline-3-carboxamide) | A cell-permeable 4-hydroxy-2-oxo quinoline carboxamide that acts as an agonist of AMPK signaling. It is shown to reduce fat storage in C. elegans (EC50 ~0.1uM) and reduce the expression level of fat-7 (a C. elegans ortholog of mammalian stearoyl-CoA desaturase-1), through aak-1 (an ortholog for the AMPK-a1 catalytic subunit) and K08F8.2 (a transcription factor) dependent mechanisms. In addition, it markedly reduces the number of lipid droplets in HepG2 human hepatocarcinoma cells at 25uM, and elicits the phosphorylation and inactivation of acetyl coenzyme A carboxylase (ACC, the enzyme that catalyzes the rate-limiting step in de novo fatty acid synthesis). F17-induced ACC phosphorylation can be abrogated by simultaneous treatment with an AMPK inhibitor compound C. Group: Biochemicals. Grades: Highly Purified. CAS No. 280112-24-5. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| CAY10566 | Stearoyl-CoA desaturase (SCD) is an endoplasmic reticulum enzyme that catalyzes the rate-limiting step in the formation of monounsaturated fatty acids (MUFAs), specifically oleate and palmitoleate from stearoyl-CoA and palmitoyl-CoA. CAY10566 is a potent and selective inhibitor with IC50s of 4.5 and 26 nM in mouse and human enzymatic assays, respectively. It also shows excellent cellular activity in blocking the conversion of saturated long-chain fatty acid-CoAs (LCFA-CoAs) to monounsaturated LCFA-CoAs in HepG2 cells. Synonyms: CAY 10566; CAY-10566. Grades: ≥98%. CAS No. 944808-88-2. Molecular formula: C18H17ClFN5O2. Mole weight: 389.8. | |
| CP 24,879 hydrochloride | CP 24,879 is an inhibitor of arachidonic acid biosynthesis by inhibition of Δ5/Δ6 desaturase. Synonyms: p-(Isopentyloxy)-aniline; 4-(3-methylbutoxy)-benzenamine monohydrochloride. Grades: ≥98%. CAS No. 10141-51-2. Molecular formula: C11H17NO·HCl. Mole weight: 215.8. | |
| Δ12 acyl-lipid conjugase (11E,13E-forming) | The enzyme, characterized from the plants Impatiens balsamina, Momordica charantia (bitter gourd) and Vernicia fordii (tung tree), converts a single cis double bond at carbon 12 to two conjugated trans bonds at positions 11 and 13. The enzyme from Vernicia fordii can also act as a 12(E) desaturase when acting on the monounsaturated fatty acids oleate and palmitoleate. cf. EC 1.14.19.16, linoleoyl-lipid Δ12 conjugase (11E,13Z-forming). Group: Enzymes. Synonyms: fatty acid Δ12-conjugase (ambiguous); FADX (gene name). Enzyme Commission Number: EC 1.14.19.33. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0997; Δ12 acyl-lipid conjugase (11E,13E-forming); EC 1.14.19.33; fatty acid Δ12-conjugase (ambiguous); FADX (gene name). Cat No: EXWM-0997. | |
| D-Eritadenine | D-Eritadenine is an adenosine analog and a potent, reversible inhibitor of S-adenosylhomocysteine hydrolase. Dietary administration of D-eritadenine (50 mg/kg) increases liver microsomal phosphatidylethanolamine concentration and decreases liver microsomal Δ6 desaturase activity and plasma cholesterol levels in rats. Uses: Enzyme inhibitors. Synonyms: (αR,βR)-6-Amino-α,β-dihydroxy-9H-purine-9-butanoic Acid; 4-(6-Amino-9H-purin-9-yl)-4-deoxy-D-erythronic Acid; 4-(6-Aminopurin-9-yl)-4-deoxy-D-erythronic Acid; Lentinacin; Lentysine; 4-(9-Adenyl)-D-erythro-2,3-dihydroxybutyric Acid; Eritadenine; Lentysine; Lentinacin. Grades: ≥95%. CAS No. 23918-98-1. Molecular formula: C9H11N5O4. Mole weight: 253.21. | |
| Elemicin | Elemicin is a alkenylbenzene widely distributed in many herbs and spices. Elemicin inhibits Stearoyl-CoA Desaturase 1 (SCD1) by metabolic activation. Elemicin is one of the main components in aromatic food and has antimicrobial, antioxidant, and antiviral activities. Elemicin possesses genotoxicity and carcinogenicity. Group: Inhibitors. Alternative Names: 1,2,3-TRIMETHOXY-5-(2-PROPENYL)BENZENE;5-ALLYL-1,2,3-TRIMETHOXYBENZENE;ELEMICIN;1,2,3-trimethoxy-5-(2-propenyl)-benzen;1,2,3-trimethoxy-5-allylbenzene (elemicin);3,4,5-Trimethoxyallylbenzene;4-allyl-1,2,6-trimethoxybenzene;5-allyl-1,2,3-trimethoxy-benzen. CAS No. 487-11-6. Molecular formula: C12H16O3. Mole weight: 208.3. Appearance: Oil. Purity: 0.98. IUPACName: 1,2,3-trimethoxy-5-prop-2-enylbenzene. Canonical SMILES: COC1=CC(=CC(=C1OC)OC)CC=C. Density: 1.011 g/cm³. Catalog: ACM487116. |  |
| Elemicin | Elemicin is an orally active alkenylbenzene widely distributed in many herbs and spices. Elemicin inhibits Stearoyl-CoA Desaturase 1 (SCD1) by metabolic activation. Elemicin has anti-influenza activities, antimicrobial , antioxidant, and antiviral activities. Elemicin and its reactive metabolite of 1-Hydroxyelemicin can induce hepatotoxicity [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 487-11-6. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-N6807. |  |
| MK-8245 | MK-8245 is a liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy. Synonyms: 4-(2-Bromo-5-fluorophenoxy)-1-[5-(2H-tetrazol-5-yl)-3-isoxazolyl]piperidine; MK-8245; MK8245; MK8245. Grades: 0.98. CAS No. 1030612-90-8. Molecular formula: C17H16BrFN6O4. Mole weight: 467.25. | |
| MK-8245 | MK-8245 is a potent, liver-targeted stearoyl-CoA desaturase (SCD) inhibitor, with IC 50 s of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with antidiabetic and antidyslipidemic efficacy [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1030612-90-8. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13070. | |
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