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100g Pack Size. Group: Building Blocks, Organics, Pyrimidines. Formula: C4H6N4O. CAS No. 56-06-4. Prepack ID 10931062-100g. Molecular Weight 126.12. See USA prepack pricing.
2,4-Diamino-6-hydroxypyrimidine
2,4-Diamino-6-hydroxypyrimidine. Group: Biochemicals. Alternative Names: 2,6-Diamino-4(1H)-pyrimidinone; 2,6-Diaminopyrimidin-4-one; 6-Aminoisocytosine; NSC 44914; NSC 680818; NSC 9302. Grades: Highly Purified. CAS No. 56-06-4. Pack Sizes: 10g. US Biological Life Sciences.
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2,4-Diamino-6-hydroxypyrimidine
2,4-Diamino-6-hydroxypyrimidine has been found to be a GCH1 inhibitor and could suppress the activity of NO synthase through preventing the synthesis of BH4. Uses: Enzyme inhibitors. Synonyms: 2,6-Diamino-4(1H)-pyrimidinone; 2,6-Diaminopyrimidin-4-one; 6-Aminoisocytosine; NSC 44914; NSC 680818; NSC 9302; 4(3H)-Pyrimidinone, 2,6-diamino-; 2,6-Diamino-4(3H)-pyrimidinone; 4(1H)-Pyrimidinone, 2,6-diamino-; 2,4-Diamino-6-pyrimidinone; 2,6-Diamino-1,4-dihydropyrimidin-4-one; 2,6-Diamino-1H-pyrimidin-4-one; 2,6-Diamino-3,4-dihydropyrimidin-4-one; 2,6-Diamino-3H-pyrimidin-4-one; 2,6-Diamino-4-pyrimidinol; 4-Hydroxypyrimidine-2,6-diamine; 6-Hydroxy-2,4-diaminopyrimidine; 6-Hydroxy-2,4-pyrimidinediamine. Grades: ≥95%. CAS No. 56-06-4. Molecular formula: C4H6N4O. Mole weight: 126.12.
2,4-Diamino-6-mercapto-pyrimidine sulfate. Group: Biochemicals. Grades: Highly Purified. CAS No. 307496-37-3. Pack Sizes: 1g, 2g, 5g. US Biological Life Sciences.
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2,4-DIAMINO-6-PHENYL-THIENO[3,2-D]PYRIMIDINE
Heterocyclic Organic Compound. Alternative Names: 2,4-DIAMINO-6-PHENYL-THIENO[3,2-D]PYRIMIDINE. CAS No. 109879-88-1. Catalog: ACM109879881.
2,4-Diamino-6-piperidinopyrimidine 3-N-oxide
2,4-Diamino-6-piperidinopyrimidine 3-N-oxide. Group: Biochemicals. Alternative Names: 6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide; 2,4-Minoxidil. Grades: Highly Purified. CAS No. 38304-91-5. Pack Sizes: 25g, 50g, 100g, 250g, 500g. Molecular Formula: C9H15N5O. US Biological Life Sciences.
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2,4-Diaminopyrimidine 3-N-Oxide
2,4-Diaminopyrimidine 3-N-Oxide is a useful organic synthetic reagent for the preparation of pyrimidines and in the making of hair loss and skin care compositions. Group: Biochemicals. Grades: Highly Purified. CAS No. 74638-76-9. Pack Sizes: 250mg, 1g. Molecular Formula: C4H6N4O, Molecular Weight: 126.12. US Biological Life Sciences.
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2,4-Diaminopyrimidine-5-carbonitrile
Intermediate for the preparation of medicines and agrochemicals. Group: Biochemicals. Alternative Names: 2,4-Diamino-5-cyanopyrimidine; 2, 4-Diamino-5-pyrimidinecarbonitri le; NSC 135235. Grades: Highly Purified. CAS No. 16462-27-4. Pack Sizes: 250mg. US Biological Life Sciences.
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2,4-Diaminopyrimidine-5-carboxaldehyde
Intermediate for the preparation of medicines and agrochemicals. Group: Biochemicals. Alternative Names: 2, 4-Diamino-5-pyrimidinecarboxalde hyde; 2, 6-Diamino-5-pyrimidinecarboxalde hyde; NSC 211353. Grades: Highly Purified. CAS No. 20781-06-0. Pack Sizes: 250mg. US Biological Life Sciences.
2,5-Diamino-2,3-dihydrothiazolo[4,5-d]pyrimidine-7-(6H)-one. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 100mg. US Biological Life Sciences.
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2,6-Diamino-4-(benzyloxy)pyrimidine
2,6-Diamino-4-(benzyloxy)pyrimidine. Group: Biochemicals. Alternative Names: 6-(Phenylmethoxy)-2,4-pyrimidinediamine; 2,4-Diamino-6-(benzyloxy)-pyrimidine; NU 6038. Grades: Highly Purified. CAS No. 100061-59-4. Pack Sizes: 1g. US Biological Life Sciences.
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2,6-Diamino-4-hydroxy-5-nitrosopyrimidine
2,6-Diamino-4-hydroxy-5-nitrosopyrimidine. Group: Biochemicals. Alternative Names: 2,6-Diamino-5-nitroso-4-pyrimidinol; 2,6-Diamino-5-nitro-4(3H)-pyrimidinone; NSC 44924. Grades: Highly Purified. CAS No. 3346-23-4. Pack Sizes: 1g, 2g, 5g, 10g, 25g. Molecular Formula: C4H5N5O2. US Biological Life Sciences.
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2,6-Diamino-4-hydroxy-5-nitrosopyrimidine-13C2
2,6-Diamino-4-hydroxy-5-nitrosopyrimidine-13C2 is a labelled 2,6-Diamino-4-hydroxy-5-nitrosopyrimidine (D416350), used in the preparation of pterin-based inhibitors. Group: Biochemicals. Alternative Names: 2,6-Diamino-5-nitroso-4-pyrimidinol-13C2; 2,6-Diamino-5-nitro-4(3H)-pyrimidinone-13C2; NSC 44924-13C2. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
4,6-Diamino-1-(b-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine is a highly intricate and advanced nucleoside analogue ingeniously applied in the research of DNA and RNA virus-induced afflictions, notably herpes simplex virus and human immunodeficiency virus (HIV). It orchestrates an awe-inspiring mechanism of action that proficiently impedes viral DNA replication, effectively halting viral dissemination and correspondingly studying associated maladies. Synonyms: 2-Amino-8-aza-7-deazaadenosine; 1H-Pyrazolo[3,4-d]pyrimidine-4,6-diamine, 1-β-D-ribofuranosyl-; (2R,3R,4S,5R)-2-(4,6-Diamino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol; 1-(β-D-Ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine. Grades: ≥95%. CAS No. 70421-30-6. Molecular formula: C10H14N6O4. Mole weight: 282.26.
4,6-Diamino-2-(b-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine, an immensely powerful antiviral agent employed within the realms of the biomedical field, manifests a remarkably inhibitory prowess against viral DNA polymerases, specifically those conjoined with the notorious herpes viruses. This exceptional compound has exhibited tremendous potential in combating ailments stemming from herpes simplex viruses (HSV-1 and HSV-2) as well as varicella-zoster virus (VZV), culprits responsible for triggering afflictions like cold sores, genital herpes, and shingles. Synonyms: 4,6-Diamino-2-(β-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine; 6-Amino-2,5-dihydro-2-(beta-D-ribofuranosyl)-4H-pyrazolo[3,4-d]pyrimidin-4-one; 2-(β-D-Ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine-4,6-diamine. Grades: ≥95%. CAS No. 124137-35-5. Molecular formula: C10H14N6O4. Mole weight: 282.26.
4,6-Diamino-3-iodo-1-(b-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine, a remarkable and potent biomedicine, represents a breakthrough in the realm of cancer treatment. Through its inhibitory properties, this compound seamlessly targets and disrupts the activities of precise enzymes involved in unregulated cell proliferation. Pioneering research has unequivocally showcased its exceptional efficacy in mitigating the insidiousness of leukemia, glioblastoma, and solid tumors. The intricate molecular composition of this product not only assures its promising potential but also incites further exploration in the realm of cancer therapeutics. Synonyms: 4,6-Diamino-3-iodo-1-(β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine; 1H-Pyrazolo[3,4-d]pyrimidine-4,6-diamine, 3-iodo-1-β-D-ribofuranosyl-; 3-Iodo-1-(β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine. Grades: ≥95%. CAS No. 908143-13-5. Molecular formula: C10H13IN6O4. Mole weight: 408.15.
4, 6-Diamino-5- (formylamino) pyrimidine hydrochloride. Group: Biochemicals. Grades: Highly Purified. CAS No. 5122-36-1. Pack Sizes: 25mg, 50mg, 100mg. Molecular Formula: C5H7N5O·HCl. US Biological Life Sciences.
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4,6-Diaminopyrimidine
4,6-Diaminopyrimidine. Group: Biochemicals. Alternative Names: 4,6-Pyrimidinediamine; NSC 211429. Grades: Highly Purified. CAS No. 2434-56-2. Pack Sizes: 2.5g. Molecular Formula: C4H6N4, Molecular Weight: 110.12. US Biological Life Sciences.
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4-Chloro-2,6-diaminopyrimidine
4-Chloro-2,6-diaminopyrimidine. Group: Biochemicals. Alternative Names: 6-chloro-2,4-diamino-pyrimidine. Grades: Highly Purified. CAS No. 156-83-2. Pack Sizes: 50g, 100g, 250g, 500g, 1kg. Molecular Formula: C4H5ClN4. US Biological Life Sciences.
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5,6-Diamino-4-hydroxypyrimidine
A key intermediate in production of HCV (Hepatitis C virus) antivirals. Group: Biochemicals. Alternative Names: 5,6-Diamino-4(3H)-pyrimidinone; 5,6-Diamino-4-pyrimidinol; NSC 36908. Grades: Highly Purified. CAS No. 1672-50-0. Pack Sizes: 200mg. US Biological Life Sciences.
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5,6-Diamino-4-hydroxypyrimidine-13C,15N
A key intermediate in production of HCV (Hepatitis C virus) antivirals. Group: Biochemicals. Alternative Names: 5,6-Diamino-4(3H)-pyrimidinone-13C,15N; 5,6-Diamino-4-pyrimidinol-13C,15N; NSC 36908-13C,15N. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences.
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5-Pyrimidinecarboxaldehyde,4,6-diamino-(9ci)
Heterocyclic Organic Compound. CAS No. 109831-68-7. Catalog: ACM109831687.
A cell-permeable, pyrimidine derivative that acts as an ATP-competitive CDK Inhibitor (Ki=2.5uM for CDK1, and Ki=1.3uM for CDK2), and demonstrates cytostatic properties among a panel of 57 cancer cell lines. Also inhibits ATR kinase (IC50=6.7uM in MCF7 cells), but does not interfere with irradiation-induced autophosphorylation of DNA-PK or ATM. Potentiates a range of DNA-damaging cytotoxic drugs such as hydroxyurea (1.8-fold) and cisplatin (1.4-fold) at 10uM, but not the anti-mitotic paclitaxel. Attenuates G2/M arrest following DNA damage and inhibits RAD51 focus formation. Shown to be synthetically lethal when DNA single-strand break repair is impaired in PARP-inhibited cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 220036-08-8. Pack Sizes: 10mg. US Biological Life Sciences.
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Ethyl-2,4-diamino-pyrimidine-5-carboxylate
Ethyl-2,4-diamino-pyrimidine-5-carboxylate. Group: Biochemicals. Grades: Highly Purified. CAS No. 15400-54-1. Pack Sizes: 250mg, 500mg, 1g, 2g, 5g. US Biological Life Sciences.
Ethyl-2,4-diamino-pyrimidine-5-carboxylate ≥95% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 100mg, 250mg, 1g, 5g. US Biological Life Sciences.
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Pyrrolidinyl diaminopyrimidine oxide
Pyrrolidinyl diaminopyrimidine oxide is a profoundly intricate compound that has exhibited excellent potential for drug development to tackle inflammation and cancer. By selectively blocking protein kinases responsible for cell proliferation and survival, it provides a vast scope for treating multiple ailments. Clinically, Pyrrolidinyl diaminopyrimidine oxide delivers remarkable results in suppressing an array of tumors and inflammation-triggering conditions of varying severity. Synonyms: 2,6-diamino-4-(pyrrolidin-1-yl)pyrimidine 1-oxide; Triaminodil. Grades: 97%. CAS No. 55921-65-8. Molecular formula: C8H13N5O. Mole weight: 195.22.
1,3-Dibutyl-5,6-diaminouracil
Intermediate in the preparation of disubstituted Xanthine derivatives. Group: Biochemicals. Alternative Names: 5,6-Diamino-1,3-dibutyl-2,4(1H,3H)-pyrimidinedione. Grades: Highly Purified. CAS No. 52998-23-9. Pack Sizes: 250mg. US Biological Life Sciences.
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1-Methyl-4-(4-nitrophenyl)piperazine
1-methyl-4-(4-nitrophenyl)piperazine was a reagent in the preparation of diaminopyrimidines as reversible and irreversible inhibitors of mutant EGFR tyrosine kinases for treatment of non-small-cell lung cancer. It was also used in the prepn. of disubstituted pyrimidine compds. as EGFR or/and ALK inhibitors useful in the treatment of diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 16155-03-6. Pack Sizes: 500mg, 1g. Molecular Formula: C11H15N3O2, Molecular Weight: 221.26. US Biological Life Sciences.
2-[2-(2-Furanyl)-5-pyrimidinyl]-7-methyl-1H-benzimidazole is synthesized from 2,3-Diaminotoluene (D416825) that is an inducer of CYP1A activity, possible mutagenic carcinogen; and 2- (2-Furyl) -5-pyrimidinecarbalde hyde, which is a synthetic block. Group: Biochemicals. Grades: Highly Purified. CAS No. 1244902-84-8. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C16H12N4O, Molecular Weight: 276.29. US Biological Life Sciences.
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2, 4-Bis (benzylamino) pyrimidine
2, 4-Bis (benzylamino) pyrimidine is an intermediate in the synthesis of pro-apoptotic agents based on 2,4-diaminoquinazoline, 2,4-diaminopyrido[2,3-d]pyrimidine and 2,4-diaminopyrimidine derivatives. Group: Biochemicals. Grades: Highly Purified. CAS No. 65448-40-0. Pack Sizes: 250mg, 500mg. Molecular Formula: C18H18N4. US Biological Life Sciences.
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2, 4-Dichloro-6-trifluoro methyl pyrimidine
2, 4-Dichloro-6-trifluoro methyl pyrimidine is a useful synthetic intermediate. It can be used to synthesize 2,4-diaminopyrimidines derivatives that show antiplasmodial activities. Group: Biochemicals. Grades: Highly Purified. CAS No. 16097-64-6. Pack Sizes: 1g, 2.5g. Molecular Formula: C5HCl2F3N2, Molecular Weight: 216.98. US Biological Life Sciences.
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2,4-Dihydroxypyrido[3,2-d]pyrimidine
2,4-Dihydroxypyrido[3,2-d]pyrimidine is used as a reagent in the synthesis of diaminoquinazolines as antitubercular agents. 2,4-Dihydroxypyrido[3,2-d]pyrimidine may also be used as a potential histamine H4 receptor antagonist. Group: Biochemicals. Grades: Highly Purified. CAS No. 37538-68-4. Pack Sizes: 50mg, 100mg. Molecular Formula: C7H5N3O2, Molecular Weight: 163.13. US Biological Life Sciences.
The reaction proceeds in the opposite direction. A step in riboflavin biosynthesis, NADPH and NADH function equally well as reductant. Differs from EC 1.1.1.193 [5-amino-6-(5-phosphoribosylamino)uracil reductase] since it does not catalyse the reduction of 5-amino-6-ribosylaminopyrimidine-2,4(1H,3H)-dione 5'-phosphate. Group: Enzymes. Synonyms: 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase; MjaRED; MJ0671 (gene name). Enzyme Commission Number: EC 1.1.1.302. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0213; 2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase; EC 1.1.1.302; 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase; MjaRED; MJ0671 (gene name). Cat No: EXWM-0213.
2,6-Diamino-4-pyrimidinyl p-Toluenesulfonate 3-Oxide. Group: Biochemicals. Alternative Names: 2,6-Diamino-4-pyrimidinol 4- (4-Methyl Benzene sulfonate) 1-Oxide; 6-Tosyloxy-2,4-diaminopyrimidine 3-Oxide. Grades: Highly Purified. CAS No. 75105-16-7. Pack Sizes: 100mg. Molecular Formula: C11H12N4O4S, Molecular Weight: 296.3. US Biological Life Sciences.
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2-Amino-8-aza-7-deoxy-2'-deoxyadenosine
2-Amino-8-aza-7-deoxy-2'-deoxyadenosine, a potent nucleoside analog, exhibits both anti-viral and anti-tumor properties and operates by integrating into the DNA of malignant cells, triggering cell death. Its exceptional action mechanism has led to it being investigated as a promising therapeutic agent for a range of cancers and viral infections, including hep B and HIV. Synonyms: 4,6-Diamino-1-(2-deoxy-b-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine; (2R,3S,5S)-5-(4,6-Diamino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol; 1-(2-Deoxy-α-D-erythro-pentofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine. Grades: ≥95%. CAS No. 117818-23-2. Molecular formula: C10H16N6O3. Mole weight: 268.27.
4-Demethyltrimethoprim
4-Demethyltrimethoprim is an impurity of Trimethoprim (T795615), an antibacterial agent. Group: Biochemicals. Alternative Names: 4-[(2,4-Diamino-5-pyrimidinyl)methyl]-2,6-dimethoxyphenol; α-(2,4-Diamino-5-pyrimidinyl)-2,6-dimethoxy-p-cresol; 2, 4-Diamino-5- (3, 5-dimethoxy-4-hydroxybenzyl) pyrimidine; 2, 4-Diamino-5- (4-hydroxy-3, 5-dimethoxybenzyl) pyrimidine; 4'-Hydroxytrimethoprim; Ro 5-9552/001. Grades: Highly Purified. CAS No. 21253-58-7. Pack Sizes: 10mg. US Biological Life Sciences.
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4-Desmethoxy-4-bromo Trimethoprim
An impurity of Trimethoprim with inhibitory effects on the enzyme dihydrofolate reductase. Group: Biochemicals. Alternative Names: 5-[ (3-Bromo-4, 5-dimethoxyphenyl) methyl]-2, 4-diaminopyrimidine; 2, 4-Diamino-5- (5-bromoveratryl) pyrimidine; 2, 4-Diamino-5- (3, 4-dimethoxy-5-bromobenzyl) pyrimidine; 2, 4-Diamino-5- (3-bromo-4, 5-dimethoxybenzyl) pyrimidine; 5-(3'-Bromo-4',5'-dimethoxybenzyl)-2,4-diaminopyrimidine. Grades: Highly Purified. CAS No. 16285-82-8. Pack Sizes: 50mg. US Biological Life Sciences.
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5,6-Diamino-2-thiouracil
Key intermediate in the production of anticancer and analgesic agents. Group: Biochemicals. Alternative Names: 5,6-Diamino-2,3-dihydro-2-thioxo-4(1H)-pyrimidinone; 5,6-Diamino-2-thio-uracil; 2-Mercapto-4,5-diamino-6-hydroxypyrimidine; 4,5-Diamino-2-mercaptopyrimidin-6-ol; 4,5-Diamino-6-hydroxy-2-mercaptopyrimidine; 5,6-Diamino-2-thiouracil; NSC 147804; NSC 45759. Grades: Highly Purified. CAS No. 1004-76-8. Pack Sizes: 250mg. US Biological Life Sciences.
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5,6-Diamino-2-thiouracil-13C,15N
Key intermediate in the production of anticancer and analgesic agents. Group: Biochemicals. Alternative Names: 5,6-Diamino-2,3-dihydro-2-thioxo-4(1H)-pyrimidinone-13C,15N; 5,6-Diamino-2-thio-uracil;-13C,15N 2-Mercapto-4,5-diamino-6-hydroxypyrimidine-13C,15N; 4,5-Diamino-2-mercaptopyrimidin-6-ol-13C,15N; 4,5-Diamino-6-hydroxy-2-mercaptopyrimidine-13C,15N; 5,6-Diamino-2-thiouracil-13C,15N; NSC 147804-13C,15N; NSC 45759-13C,15N. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
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5,6-Diamino-4-thiouracil
Intermediate for the synthesis of Thiouric Acid. Group: Biochemicals. Alternative Names: 4,5-Diamino-6-mercapto-2-hydroxypyrimidine; 5,6-Diamino-3,4-dihydro-4-thioxo-2(1H)-pyrimidinone. Grades: Highly Purified. CAS No. 40848-33-7. Pack Sizes: 500mg. US Biological Life Sciences.
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5,6-Diaminouracil
5,6-Diaminouracil (CAS# 3240-72-0) is a useful research chemical. Synonyms: 5,6-Diamino-2,4-dihydroxypyrimidine; 4,5-Diaminouracil; 5,6-diamino-1H-pyrimidine-2,4-dione; 2,4(1H,3H)-Pyrimidinedione, 5,6-diamino-, monohydrochloride; 5,6-DIAMINOURACIL MONOHYDROCHLORIDE; 5,6-diaminopyrimidine-2,4(1H,3H)-dione; 4,5-DIAMINOURACIL,HYDROCHLORIDE SALT. Grades: ≥ 95 %. CAS No. 3240-72-0. Molecular formula: C4H7ClN4O2. Mole weight: 178.58.
6- (4-Fluorophenyl) pyrimidine-2, 4-diamine
6- (4-Fluorophenyl) pyrimidine-2, 4-diamine. Group: Biochemicals. Alternative Names: 2, 4-Diamino-6- (4-fluorophenyl) pyrimidine. Grades: Highly Purified. CAS No. 175137-25-4. Pack Sizes: 1g, 2g, 5g. US Biological Life Sciences.
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6-(4-Fluorophenyl)pyrimidine-2,4-diamine
6-(4-Fluorophenyl)pyrimidine-2,4-diamine, a chemical compound utilized in the production of pharmaceutical drugs, has been thoroughly examined to investigate its potential as a tyrosine kinase inhibitor, serving as an impediment to the proliferation and migration of cancer cells that may bring forth possible treatment for various cancers. Furthermore, groundbreaking research has indicated its potential in being therapeutically effective in devastating illnesses like Parkinson's and Alzheimer's, providing a beacon of hope in the medical field. Synonyms: 2,4-Diamino-6-(4-fluorophenyl)pyrimidine. Grades: ≥ 95%. CAS No. 175137-25-4. Molecular formula: C10H9FN4. Mole weight: 204.20.
6-Ethyl-5-(4-nitrophenyl)-2,4-pyrimidinediamine
A diaminopyrimidine derivative with antimalarial and antibacterial properties. Group: Biochemicals. Alternative Names: 2,4-Diamino-6-ethyl-5-(p-nitrophenyl)-pyrimidine; NSC 372954. Grades: Highly Purified. CAS No. 71552-34-6. Pack Sizes: 250mg. US Biological Life Sciences.
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AR709
AR709 is a novel diaminopyrimidine antibiotic. It is currently in development for treatment of community-acquired upper and lower respiratory tract infections. It showed excellent activity against both drug-susceptible and multidrug-resistant pneumococci. Uses: Ar709 is currently in development for treatment of community-acquired upper and lower respiratory tract infections. Synonyms: AR-709; AR 709; 1H-Indole-2-carboxamide, 5-chloro-3-((4-((2,4-diamino-5-pyrimidinyl)methyl)-6,7-dimethoxy-2-benzofuranyl)methyl)-N,N-dimethyl-. Grades: 98%. CAS No. 663214-64-0. Molecular formula: C27H27ClN6O4. Mole weight: 535.00.
A structural derivative of Trimethoprim. A selective dihydrofolate reductase inhibitor; diaminopyridine antibacterial agent. Group: Biochemicals. Alternative Names: 5-[ (4-Bromo-3, 5-dimethoxyphenyl) methyl]-2, 4-pyrimidinediamine; 5-(4-Bromo-3, 5-dimethoxybenzyl)-2, 4-pyrimidinediamine; Hyprim; Ro 10-5970; Ro 105970; Unitrim. Grades: Highly Purified. CAS No. 56518-41-3. Pack Sizes: 25mg. US Biological Life Sciences.
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Brodimoprim-d6
A labeled structural derivative of Trimethoprim. A selective dihydrofolate reductase inhibitor; diaminopyridine antibacterial agent. Group: Biochemicals. Alternative Names: 5-[(4-Bromo-3,5-(dimethoxy-d6)phenyl)methyl]-2,4-pyrimidinediamine; 5-(4-Bromo-3,5-(dimethoxy-d6)benzyl)-2,4-pyrimidinediamine; Hyprim-d6; Ro 10-5970-d6; Ro 105970-d6; Unitrim-d6. Grades: Highly Purified. CAS No. 1346599-93-6. Pack Sizes: 1mg. US Biological Life Sciences.
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cyanuric acid amidohydrolase
Along with EC 3.5.1.54 (allophanate hydrolase) and EC 3.5.1.84 (biuret amidohydrolase), this enzyme forms part of the cyanuric-acid metabolism pathway, which degrades s-triazide herbicides, such as atrazine [2-chloro-4-(ethylamino)-6-(isopropylamino)-1,3,5-triazine], in bacteria. This is a key enzyme in the pathway, catalysing the ring cleavage of cyanuric acid. The enzyme is specific for cyanuric acid as substrate as neither the structurally related compounds ammeline (2,4-diamino-6-hydroxy-s-triazine) and ammelide (2-amino-4,6-dihydroxy-s-triazine) nor a number of pyrimidine compounds, such as uracil and cytosine, can act as substrates. Group: Enzymes. Synonyms: AtzD. Enzyme Commission Number: EC 3.5.2.15. CAS No. 132965-78-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4498; cyanuric acid amidohydrolase; EC 3.5.2.15; 132965-78-7; AtzD. Cat No: EXWM-4498.
Dicyclanil
Dicyclanil. Group: Biochemicals. Alternative Names: 4, 6-Diamino-2- (cyclopropyl amino) -5-pyrimidinecarbonitri le; 2-(Cyclopropylamino)-4,6-diamino-5-cyanopyrimidine; 4, 6-Diamino-2- (cyclopropyl amino) -5-pyrimidinecarbonitri le; CLiK. Grades: Highly Purified. CAS No. 112636-83-6. Pack Sizes: 250mg. Molecular Formula: C8H10N6, Molecular Weight: 190.21. US Biological Life Sciences.
An orally bioavailable fluoro-diaminopyrimidine compound that acts as a potent, reversible and ATP-competitive inhibitor of LRRK2 activity (IC50=4.76 and 6.87nM for hr-wt-LRRK2 and G2019S-LRRK2 mutant, respectively) with selectivity over PLK4, GAK, TNK1, CAMKK2, and PIP4K2C (IC50 <300nM) in a 185-kinase panel. Does neither exert cytotoxicity nor block neuronal development of human or rat cortical neurons at 1uM. Shown to prevent GS-LRRK2-induced neuronal injury (EC50 ~4nM) and G2019S- or R1441C-LRRK2-mediated neuronal death in both rat and human cortical neurons (EC50 ~100nM). Even though exhibits favorable pharmacokinetic profile and metabolic stability, and yet suffers from limited blood brain barrier penetration (~4%). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
Metoprine
A 2,4-Diaminopyrimidine derivative as antimalarial agent. Group: Biochemicals. Alternative Names: 5-(3,4-Dichlorophenyl)-6-methyl-2,4-pyrimidinediamine; 2,4-Diamino-5-(3,4-dichlorophenyl)-6-methylpyrimidine; 2,4-Diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine; BW 197U; BW 50197; DDMP; Methodichlorophen; NSC 19494; NSC 7364; SK 5265; U 197. Grades: Highly Purified. CAS No. 7761-45-7. Pack Sizes: 25mg. US Biological Life Sciences.
Worldwide
Metoprine
Metoprine (BW 197U) is a potent histamine N-methyltransferase (HMT) inhibitor. Metoprine, a diaminopyrimidine derivative, can cross the blood-brain barrier and increase brain histamine levels by inhibiting HMT. Metoprine is an antifolate and antitumor agent. Group: Inhibitors. Alternative Names: 5-(3,4-Dichlorophenyl)-6-methyl-2,4-pyrimidinediamine; 2,4-Diamino-5-(3,4- dichlorophenyl)-6-methylpyrimidine; 2,4-Diamino-5-(3',4'-dichlorophenyl)- 6-methylpyrimidine; BW 197U; BW 50197; DDMP; Methodichlorophen; NSC 19494; NSC 7364; SK 5265; U 197. CAS No. 7761-45-7. Molecular formula: C11H10Cl2N4. Mole weight: 269.13. Appearance: Solid. Purity: 0.96. IUPACName: 5-(3,4-dichlorophenyl)-6-methylpyrimidine-2,4-diamine. Canonical SMILES: CC1=C (C (=NC (=N1)N)N)C2=CC (=C (C=C2)Cl)Cl. Density: 1.447g/cm³. Catalog: ACM7761457.
Minoxidil
Minoxidil is a vasodilator medication known for its ability to slow or stop hair loss and promote hair regrowth. Uses: Antihypertensive agents; vasodilator agents. Synonyms: 2,4-Pyrimidinediamine, 6-(1-piperidinyl)-, 3-oxide; 2,4-Diamino-6-(1-piperidinyl)-pyrimidine-3-oxide; 2,4-Diamino-6-piperidinopyrimidine 3-N-oxide; 2,4-Diamino-6-piperidinopyrimidine 3-oxide; 2,6-Diamino-4-(piperidin-1-yl)pyrimidin-1-ium-1-olate; 6-Amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine; Alopexil; Alostil; Loniten; Lonolox; Minoximen; Mintop; Normoxidil; PDP; Pierminox; Prexidil; Regro EX 5; RiUP; Riup X5; Rogaine; Tricoxidil; U 10858. Grades: >98%. CAS No. 38304-91-5. Molecular formula: C9H15N5O. Mole weight: 209.25.
Minoxidil Impurity A
6-Chloro-pyrimidine-2,4-diamine 3-Oxide is an impurity of the antihypertensive and antialopecia agent Minoxidil. Synonyms: 6-Chloro-pyrimidine-2,4-diamine 3-Oxide; 2,6-Diamino-4-chloropyrimidine 1-Oxide; 2,4-Diamino-6-chloropyrimidine 3-N-Oxide; 2,4-Diamino-6-chloropyrimidine 3-Oxide; 6-Chloro-2,4-diaminopyrimidine 3-Oxide; NSC 137211. Grades: > 95%. CAS No. 35139-67-4. Molecular formula: C4H5ClN4O. Mole weight: 160.56.
2,6-Diamino-4-pyrimidinyl p-Toluenesulfonate 3-Oxide is used in the preparation of a hypotensive drug. It is an intermediate in the preparation of Minoxidil. Synonyms: 2,6-Diamino-4-pyrimidinyl p-Toluenesulfonate 3-Oxide; 2,6-Diamino-4-pyrimidinol 4-(4-Methylbenzenesulfonate) 1-Oxide; 6-Tosyloxy-2,4-diaminopyrimidine 3-Oxide. Grades: > 95%. CAS No. 75105-16-7. Molecular formula: C11H12N4O4S. Mole weight: 296.3.
NU6027 is a potent inhibitor of cellular ATR activity (IC(50)=6.7 μM) and enhanced hydroxyurea and cisplatin cytotoxicity in an ATR-dependent manner. NU6027 attenuated G2/M arrest following DNA damage, inhibited RAD51 focus formation and increased the cytotoxicity of the major classes of DNA-damaging anticancer cytotoxic therapy but not the antimitotic, paclitaxel. In A2780 cells sensitisation to cisplatin was greatest in cells with functional p53 and mismatch repair (MMR) and sensitisation to temozolomide was greatest in p53 mutant cells with functional MMR. Importantly, NU6027 was synthetically lethal when DNA single-strand break repair is impaired either through poly(ADP-ribose) polymerase (PARP) inhibition or defects in XRCC1. NU6027 inhibits ATR, impairing G2/M arrest and homologous recombination thus increasing sensitivity to DNA-damaging agents and PARP inhibitors. It provides proof of concept data for clinical development of ATR inhibitors. Synonyms: NU-6027; NU 6027; 2,6-Diamino-4-(cyclohexylmethoxy)-5-nitrosopyrimidine; 6-(Cyclohexylmethoxy)-5-nitroso-2,4-pyrimidinediamine; 4-Cyclohexylmethoxy-2,6-diamino-5-nitrosopyrimidine; 4-Cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine. Grades: ≥98%. CAS No. 220036-08-8. Molecular formula: C11H17N5O2. Mole weight: 251.29.
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